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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • CD3 Antibodies

          Proteintech

          CD3 Polyclonal Antibody

          76 References
          View all (542) CD3 antibodies

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          Cite CD3 Polyclonal Antibody

          • Antibody Testing Data (18)
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 18

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          CD3 Antibody (17617-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human angioimmunoblastic T-cell lymphoma using 17617-1-AP (CD3 antibody) at dilution of 1:100 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CD3 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          CD3 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          CD3 Antibody in Western Blot (WB)
          CD3 Antibody in Western Blot (WB)
          CD3 Antibody in Western Blot (WB)
          CD3 Antibody in Western Blot (WB)
          CD3 Antibody in Flow Cytometry (Flow)
          CD3 Antibody in Immunoprecipitation (IP)

          Product Details

          17617-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:3,000
          View 5 publications 5 publications

          Immunohistochemistry (IHC)

          -
          View 43 publications 43 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          1:200
          -

          Immunocytochemistry (ICC/IF)

          -
          View 19 publications 19 publications

          Flow Cytometry (Flow)

          0.5 µg/1x10^6 cells
          View 4 publications 4 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Miscellaneous PubMed (MISC)

          -
          View 2 publications 2 publications

          Not applicable (N/A)

          -
          View 3 publications 3 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Pig, Rat

          Published species

          Human, Mouse, Pig

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          CD3 Fusion Protein Ag11797 (1-207 aa encoded by BC049847)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.23 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          This anti-CD3 is a polyclonal antibody directed against the epsilon chain of human CD3 molecule.

          Immunogen sequence: MQSGTHWRV LGLCLLSVGV WGQDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMDVMS VATIVIVDIC ITGGLLLLVY YWSKNRKAKA KPVTRGAGAG GRQRGQNKER PPPVPNPDYE PIRKGQRDLY SGLNQRRI (1-207 aa encoded by BC049847)

          Target Information

          The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CD247; CD247 antigen; CD247 antigen, zeta subunit; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon subunit; CD3 gamma-chain; CD3 molecule delta polypeptide; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3 TCR complex; CD3 zeta chain; CD3-epsilon; CD3-zeta/eta; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; FLJ18683; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex; TcR CD3 delta-chain; TCR zeta chain

          View more View less

          Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; CD247; CD3; CD3-DELTA; Cd3-eta; CD3-GAMMA; CD3-ZETA; CD3D; CD3E; CD3epsilon; CD3G; CD3H; CD3Q; CD3Z; Cd3zeta; Ctg-3; Ctg3; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; Tcrk; TCRZ; TCRzeta

          View more View less

          UniProt ID: (Human) P20963, (Pig) Q764N2, (Human) P04234, (Human) P07766, (Pig) Q7YRN2, (Human) P09693, (Pig) Q5PXD3, (Mouse) P24161, (Mouse) P04235, (Rat) P19377, (Mouse) P22646, (Mouse) P11942, (Rat) Q64159

          View more View less

          Entrez Gene ID: (Human) 919, (Pig) 397302, (Pig) 396661, (Human) 915, (Human) 916, (Pig) 397455, (Human) 917, (Pig) 494013, (Rat) 25300, (Mouse) 12503, (Mouse) 12500, (Rat) 25710, (Rat) 315609, (Mouse) 12501, (Mouse) 12502, (Rat) 300678

          View more View less

          Function(s)
          transmembrane signaling receptor activity protein binding identical protein binding protein homodimerization activity transcription coactivator activity protein heterodimerization activity receptor signaling protein activity SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding molecular_function signal transducer activity
          Process(es)
          protein complex assembly cell surface receptor signaling pathway T cell activation positive thymic T cell selection viral process T cell costimulation Fc-gamma receptor signaling pathway involved in phagocytosis regulation of defense response to virus by virus regulation of immune response T cell receptor signaling pathway biological_process T cell differentiation positive regulation of transcription from RNA polymerase II promoter establishment or maintenance of cell polarity protein transport regulation of lymphocyte apoptotic process positive regulation of T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway response to nutrient positive regulation of gene expression negative regulation of gene expression positive regulation of interferon-gamma production positive regulation of interleukin-4 production positive regulation of T cell proliferation regulation of apoptotic process negative thymic T cell selection positive regulation of interleukin-2 biosynthetic process negative regulation of smoothened signaling pathway positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling apoptotic signaling pathway T cell differentiation in thymus lymphocyte activation positive regulation of T cell activation
          It has to be done as per old AB suggested Products section.
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