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Proteintech
CD3 Polyclonal Antibody
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Product Details
17617-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD3 Fusion Protein Ag11797 (1-207 aa encoded by BC049847)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This anti-CD3 is a polyclonal antibody directed against the epsilon chain of human CD3 molecule.
Immunogen sequence: MQSGTHWRV LGLCLLSVGV WGQDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMDVMS VATIVIVDIC ITGGLLLLVY YWSKNRKAKA KPVTRGAGAG GRQRGQNKER PPPVPNPDYE PIRKGQRDLY SGLNQRRI (1-207 aa encoded by BC049847)
Target Information
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD247; CD247 antigen; CD247 antigen, zeta subunit; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon subunit; CD3 gamma-chain; CD3 molecule delta polypeptide; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3 TCR complex; CD3 zeta chain; CD3-epsilon; CD3-zeta/eta; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; FLJ18683; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex; TcR CD3 delta-chain; TCR zeta chain
Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; CD247; CD3; CD3-DELTA; Cd3-eta; CD3-GAMMA; CD3-ZETA; CD3D; CD3E; CD3epsilon; CD3G; CD3H; CD3Q; CD3Z; Cd3zeta; Ctg-3; Ctg3; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; Tcrk; TCRZ; TCRzeta
transmembrane signaling receptor activity
protein binding
identical protein binding
protein homodimerization activity
transcription coactivator activity
protein heterodimerization activity
receptor signaling protein activity
SH3 domain binding
protein kinase binding
receptor signaling complex scaffold activity
T cell receptor binding
molecular_function
signal transducer activity
protein complex assembly
cell surface receptor signaling pathway
T cell activation
positive thymic T cell selection
viral process
T cell costimulation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of defense response to virus by virus
regulation of immune response
T cell receptor signaling pathway
biological_process
T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
establishment or maintenance of cell polarity
protein transport
regulation of lymphocyte apoptotic process
positive regulation of T cell anergy
transmembrane receptor protein tyrosine kinase signaling pathway
signal complex assembly
G-protein coupled receptor signaling pathway
response to nutrient
positive regulation of gene expression
negative regulation of gene expression
positive regulation of interferon-gamma production
positive regulation of interleukin-4 production
positive regulation of T cell proliferation
regulation of apoptotic process
negative thymic T cell selection
positive regulation of interleukin-2 biosynthetic process
negative regulation of smoothened signaling pathway
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
apoptotic signaling pathway
T cell differentiation in thymus
lymphocyte activation
positive regulation of T cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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