Invitrogen

CD38 Monoclonal Antibody (38C03 (SPC32))

CD38 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD38 Antibody (MA5-14413) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with CD38 using peroxidase-conjugate and AEC chromogen. Note membrane staining of lymphocytes.

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CD38 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines tested owing to their inherent genetic constitution. Relative expression of CD138 (Syndecan-1) was observed in Ramos and Daudi which is reported to be positive and not in H1299 and HCT 116 using CD38 Monoclonal Antibody (38C03 (SPC32)) (Product # MA5-14413) in western blot. {RE}

Product Details

MA5-14413

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:200

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

1:2

Product Specifications

Published species

Human, Mouse, Rabbit

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

38C03 (SPC32)

Immunogen

Recombinant protein encoding the extracellular domain of human CD38

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage conditions

4°C

Shipping conditions

Wet ice

AB_10986743

Product Specific Information

MA5-14413 targets CD38 in WB, FACS and IHC (P) applications and shows reactivity with Human and Mouse samples. This antibody is not suitable for Jurkat cell lysates or mouse thymus tissues in Western blot analysis.

The MA5-14413 immunogen is recombinant protein encoding the extracellular domain of human CD38.

Target Information

CD38 is a multifunctional ectoenzyme and type II transmembrane glycoprotein involved in various cellular processes. It catalyzes the conversion of NAD into secondary messengers such as nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR). CD38 plays a crucial role in B cell development, with expression levels fluctuating from high in immature cells to low in intermediate ones, and back to high in mature B cells. It is also present in a variety of tissues and hematopoietic cells, including T cells, NK cells, and monocytes, and is used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population is considered to define the most pluripotent hematopoietic stem cells. In addition to its surface expression, CD38 has been identified in the nucleus, where it may regulate calcium levels. It functions as a multi-catalytic ectoenzyme, serving roles as an ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase, or as a cell surface receptor. CD38 is involved in the activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It also participates in cell adhesion, signal transduction, and calcium signaling. Antibodies to CD38 are valuable for subtyping lymphomas and leukemias, detecting plasma cells (such as in myelomas), and marking activated B and T cells. CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Dysfunctions in CD38 are associated with diseases like chronic lymphocytic leukemia and Richter's Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Unusual bilateral kidney and duodenal plasmablastic lymphoma presentation in an elderly patient: A case report.

Molecular and clinical oncology

Liu YC,Su YT,Huang CK,Tsai YC,Chen YC,Li PF

MA5-14413 was used in Immunohistochemistry to describe the case of a 71-year-old man who was admitted to the emergency department with a 7-day history of progressive left flank pain and tarry stool.

Fri Jul 01 00:00:00 UTC 2022

TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.

Cell

Venturutti L,Teater M,Zhai A,Chadburn A,Babiker L,Kim D,Béguelin W,Lee TC,Kim Y,Chin CR,Yewdell WT,Raught B,Phillip JM,Jiang Y,Staudt LM,Green MR,Chaudhuri J,Elemento O,Farinha P,Weng AP,Nissen MD,Steidl C,Morin RD,Scott DW,Privé GG,Melnick AM

MA5-14413 was used in Immunohistochemistry to show that TBL1XR1 mutations skew the humoral immune response toward generating abnormal immature memory B cells (MB), while impairing plasma cell differentiation.

Thu Jul 23 00:00:00 UTC 2020

Plasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis.

Arthritis research & therapy

Mueller A,Brieske C,Schinke S,Csernok E,Gross WL,Hasselbacher K,Voswinkel J,Holl-Ulrich K

MA5-14413 was used in immunohistochemistry - paraffin section to describe the features of plasma cells in patients with granulomatosis with polyangiitis

Thu Feb 20 00:00:00 UTC 2014

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma.

Blood

Groen RW,Noort WA,Raymakers RA,Prins HJ,Aalders L,Hofhuis FM,Moerer P,van Velzen JF,Bloem AC,van Kessel B,Rozemuller H,van Binsbergen E,Buijs A,Yuan H,de Bruijn JD,de Weers M,Parren PW,Schuringa JJ,Lokhorst HM,Mutis T,Martens AC

MA5-14413 was used in Immunohistochemistry to study a unique human-mouse hybrid model that allows engraftment and outgrowth of normal and malignant haematopoietic progenitors by implementing a technology for generating a human bone environment.

Thu Jul 19 00:00:00 UTC 2012

Upregulation of tumor necrosis factor receptor-associated factor 6 correlated with synovitis severity in rheumatoid arthritis.

Arthritis research & therapy

Zhu LJ,Dai L,Zheng DH,Mo YQ,Ou-Yang X,Wei XN,Shen J,Zhang BY

MA5-14413 was used in Immunohistochemistry to investigate tumour necrosis factor receptor-associated factor 6 expression in the rheumatoid arthritis synovium, and its correlation with histological synovitis severity and radiological joint destruction in rheumatoid arthritis.

Mon Jun 04 00:00:00 UTC 2012

VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type.

PloS one

Nichele I,Zamò A,Bertolaso A,Bifari F,Tinelli M,Franchini M,Stradoni R,Aprili F,Pizzolo G,Krampera M

MA5-14413 was used in immunohistochemistry - paraffin section to discuss how Epstein-Barr virus contributes to the development of small B-cell neoplasms

Thu Jun 27 00:00:00 UTC 2013

Analysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graft.

Journal of clinical pathology

Bellan C,Amato T,Carmellini M,Onorati M,D'Amuri A,Leoncini L,del Vecchio MT

MA5-14413 was used in immunohistochemistry to investigate the role of IgVH genes in host-graft rejection in renal transplants

Sat Jan 01 00:00:00 UTC 2011

Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

Horváth E,Mezei T,Pávai Z,Turcu M,Demian S,Tóth E,Chira L,Jung I

MA5-14413 was used in immunohistochemistry to investigate the diagnosis of lymphoid neoplasmas through bone marrow trephine biopsies

Wed Dec 16 00:00:00 UTC 2009

Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform.

The Biochemical journal

Bacher I,Zidar A,Kratzel M,Hohenegger M

MA5-14413 was used in western blot to generate enzymatic data supporting the presence in skeletal muscle of an ADP-ribosyl cyclase isoform distinct from CD38

Thu Jul 01 00:00:00 UTC 2004

Human adult craniofacial muscle-derived cells: neural-cell adhesion-molecule (NCAM; CD56)-expressing cells appear to contain multipotential stem cells.

Biotechnology and applied biochemistry

Sinanan AC,Hunt NP,Lewis MP

MA5-14413 was used in immunocytochemistry to characterize muscle-derived multipotential stem cells

Sun Aug 01 00:00:00 UTC 2004

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