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Invitrogen
Epstein Barr Virus Bcl-2 Monoclonal Antibody (D44E)
Product Details
MA1-7275
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
D44E
Immunogen
EBV BCl-2 homolog.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1017109
Product Specific Information
The MA1-7275 antibody reacts with Epstein-Barr virus Bcl-2 in viral and infected tissue samples.
MA1-7275 has been successfully used in ELISA, Western blot, Immunohistochemical and Immunoprecipitation applications.
The MA1-7275 antibody was raised against EBV BCl-2 homolog protein.
Target Information
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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