Product References
Interplay between the plasma membrane and cell-cell adhesion maintains epithelial identity for correct polarised cell divisions.
Journal of cell science
Hosawi MM,Cheng J,Fankhaenel M,Przewloka MR,Elias S
A-11122 was used in Western Blot to identify S100 Ca2+-binding protein A11 (S100A11) as a key membrane-associated regulator that forms a complex with E-cadherin (CDH1) and the leucine-glycine-asparagine repeat protein LGN (also known as GPSM2) to coordinate plasma membrane remodelling with E-cadherin-mediated cell adhesion and LGN-dependent mitotic spindle machinery.
Fri Mar 01 00:00:00 UTC 2024
Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells.
Nature biotechnology
Ghasemi HI,Bacal J,Yoon AC,Tavasoli KU,Cruz C,Vu JT,Gardner BM,Richardson CD
A-11122 was used in Western Blotting to describe a strategy to boost the efficiency of gene editing via homology-directed repair (HDR) by covalently modifying the template DNA with interstrand crosslinks.
Sun Oct 01 00:00:00 UTC 2023
ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma.
Frontiers in immunology
Heim C,Moser LM,Kreyenberg H,Bonig HB,Tonn T,Wels WS,Gradhand E,Ullrich E,Meister MT,Koerkamp MG,Holstege FCP,Drost J,Klusmann JH,Bader P,Merker M,Rettinger E
A-11122 was used in Immunohistochemistry to show that NK-92/5.28.z cells effectively kill RMS cells in vitro and significantly prolong survival and inhibit tumor progression in mice.
Tue Sep 05 00:00:00 UTC 2023
Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.
PLoS genetics
Yi J,Zhao X,Noell CR,Helmer P,Solmaz SR,Vallee RB
A-11122 was used in Western Blotting to propose that mutually exclusive RanBP2-BICD2 vs. Nesprin-2-BICD2 interactions at the NE play successive, critical roles in INM behavior in RGPs and in post-mitotic neuronal migration and errors in these processes contribute to specific human brain malformations.
Wed Mar 01 00:00:00 UTC 2023
Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies.
Frontiers in microbiology
Cherkashchenko L,Gros N,Trausch A,Neyret A,Hénaut M,Dubois G,Villeneuve M,Chable-Bessia C,Lyonnais S,Merits A,Muriaux D
A-11122 was used in Immunocytochemistry to describe reverse genetic methods that include the design and validation of infectious clones of Zika, Kunjin, and Dengue viruses harboring different reporter genes for infection, rescue, imaging, and morphology using super-resolution microscopy.
Mon Oct 30 00:00:00 UTC 2023
Foxi3GFP and Foxi3CreER mice allow identification and lineage labeling of pharyngeal arch ectoderm and endoderm, and tooth and hair placodes.
Developmental dynamics : an official publication of the American Association of Anatomists
Ankamreddy H,Thawani A,Birol O,Zhang H,Groves AK
A-11122 was used in Immunohistochemistry to show that Foxi3GFP mice faithfully recapitulate the expression pattern of Foxi3 mRNA.
Fri Dec 01 00:00:00 UTC 2023
β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats.
eNeuro
Walker NB,Yan Y,Tapia MA,Tucker BR,Thomas LN,George BE,West AM,Marotta CB,Lester HA,Dougherty DA,Holleran KM,Jones SR,Drenan RM
A-11122 was used in Immunohistochemistry-immunofluorescence to report that β2* nAChR activation on VTA neurons is sufficient for nicotine reinforcement in rats.
Mon May 01 00:00:00 UTC 2023
An In Vivo Platform for Rebuilding Functional Neocortical Tissue.
Bioengineering (Basel, Switzerland)
Quezada A,Ward C,Bader ER,Zolotavin P,Altun E,Hong S,Killian NJ,Xie C,Batista-Brito R,Hébert JM
A-11122 was used in Immunohistochemistry-immunofluorescence to provide proof of a concept for an in vivo platform that can be used for developing and testing neocortical-like tissue prototypes.
Thu Feb 16 00:00:00 UTC 2023
Piezo-mediated mechanosensation contributes to stabilizing copulation posture and reproductive success in Drosophila males.
iScience
Yamanouchi HM,Tanaka R,Kamikouchi A
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that the mechanosensory system of male genitalia through Piezo channels plays a key role in copulation maintenance and indicate that Piezo may increase male fitness during copulation in flies.
Fri May 19 00:00:00 UTC 2023
Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo.
Experimental neurobiology
Lee HJ,Park JH,Trotter JH,Maher JN,Keenoy KE,Jang YM,Lee Y,Kim JI,Weeber EJ,Hoe HS
A-11122 was used in Immunocytochemistry to find that Reelin treatment significantly increased dendritic spine density and PSD-95 puncta number in primary hippocampal neurons.
Tue Feb 28 00:00:00 UTC 2023
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing.
Signal transduction and targeted therapy
Zheng X,Huang C,Lin Y,Han B,Chen Y,Li C,Li J,Ding Y,Song X,Wang W,Liang W,Wu J,Wu J,Gao J,Wei C,Zhang X,Tu Z,Yan S
A-11122 was used in Immunohistochemistry to develop an immunodeficient monkey model with the ability to foster tumor growth using the CBE4max system.
Mon Sep 04 00:00:00 UTC 2023
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nature communications
Kwon DH,Zhang F,McCray BA,Feng S,Kumar M,Sullivan JM,Im W,Sumner CJ,Lee SY
A-11122 was used in Western Blotting to suggest that RhoA serves as an auxiliary subunit for TRPV4, regulating TRPV4-mediated calcium homeostasis and disruption of TRPV4-RhoA interactions can lead to TRPV4-related neuromuscular disease.
Fri Jun 23 00:00:00 UTC 2023
Longitudinal visceral muscles in Drosophila fully dedifferentiate and fragment prior to their reestablishment during metamorphosis.
microPublication biology
Schultheis D,Frasch M
A-11122 was used in Immunohistochemistry-immunofluorescence to present our independent analysis using HLH54Fb-eGFP as a cell type specific marker, which strengthens the proposition by Aghajanian et al.
Tue Apr 04 00:00:00 UTC 2023
Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model.
Cell reports
Nukala KM,Lilienthal AJ,Lye SH,Bassuk AG,Chtarbanova S,Manak JR
A-11122 was used in Immunohistochemistry to provide direct genetic evidence that oxidative stress in combination with glial-mediated IIR leads to progression of an epilepsy disorder.
Tue Jan 31 00:00:00 UTC 2023
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.
PloS one
Wang Y,Hurley A,De Giorgi M,Tanner MR,Hu RC,Pennington MW,Lagor WR,Beeton C
A-11122 was used in Western Blotting to test the ability of Adeno-Associated Virus (AAV)8 vectors to target hepatocytes for expressing the ShK analog, ShK-235 (AAV-ShK-235) in rodents.
Thu Apr 13 00:00:00 UTC 2023
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity.
Nature communications
Goretzki B,Wiedemann C,McCray BA,Schäfer SL,Jansen J,Tebbe F,Mitrovic SA,Nöth J,Cabezudo AC,Donohue JK,Jeffries CM,Steinchen W,Stengel F,Sumner CJ,Hummer G,Hellmich UA
A-11122 was used in Western Blotting to demonstrate that IDR structural dynamics are coupled to TRPV4 activity and highlights the importance of IDRs for TRP channel function and regulation.
Thu Jul 13 00:00:00 UTC 2023
Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter.
iScience
Saenz J,Yao O,Khezerlou E,Aggarwal M,Zhou X,Barker DJ,DiCicco-Bloom E,Pan PY
A-11122 was used in Immunocytochemistry-immunofluorescence to reveal the previously unknown dynamics and molecular regulation for cocaine-regulated DAT trafficking in neuronal processes.
Fri Jan 20 00:00:00 UTC 2023
Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis.
The Journal of biological chemistry
Al-Bataineh MM,Kinlough CL,Marciszyn A,Lam T,Ye L,Kidd K,Maggiore JC,Poland PA,Kmoch S,Bleyer A,Bain DJ,Montalbetti N,Kleyman TR,Hughey RP,Ray EC
A-11122 was used in Western Blot to provide further insight into the role of MUC1 in Ca2+-selective TRP channel endocytosis and the overall effects on Ca concentrations.
Wed Mar 01 00:00:00 UTC 2023
A dedicate sensorimotor circuit enables fine texture discrimination by active touch.
PLoS genetics
Yu J,Guo X,Zheng S,Zhang W
A-11122 was used in Immunohistochemistry-immunofluorescence to propose a sensorimotor circuit composed of mechanosensory, gustatory and motor neurons that enables the flies to select ripe yet not over-rotten food by active touch.
Sun Jan 01 00:00:00 UTC 2023
mRNA recognition and packaging by the human transcription-export complex.
Nature
Pacheco-Fiallos B,Vorländer MK,Riabov-Bassat D,Fin L,O'Reilly FJ,Ayala FI,Schellhaas U,Rappsilber J,Plaschka C
A-11122 was used in Western Blot to promote their packaging for nuclear export.
Sat Apr 01 00:00:00 UTC 2023
MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice.
Acta neuropathologica communications
Göbel C,Godbole S,Schoof M,Holdhof D,Kresbach C,Loose C,Neumann J,Schüller U
A-11122 was used in Immunohistochemistry to provide first evidence for a tumor-promoting role of a SMARCA4 deficiency in the development of medulloblastoma.
Thu Nov 02 00:00:00 UTC 2023
Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells.
Nature neuroscience
Hádinger N,Bősz E,Tóth B,Vantomme G,Lüthi A,Acsády L
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunomicroscopy to show that frontal cortex functions require a highly specialized cortical control over intrathalamic inhibitory processes.
Sun Jan 01 00:00:00 UTC 2023
Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance.
Development (Cambridge, England)
Zang Y,Bashaw GJ
A-11122 was used in Immunohistochemistry-immunofluorescence to identify Fra-interacting proteins in Drosophila.
Tue Aug 01 00:00:00 UTC 2023
Leader peptide or pro-segment mutants of renin are misrouted to mitochondria in autosomal dominant tubulointerstitial kidney disease.
Disease models & mechanisms
Schaeffer C,De Fusco M,Pasqualetto E,Scolari C,Izzi C,Scolari F,Rampoldi L
A-11122 was used in Western Blotting to demonstrate a common, unprecedented effect of mutations in the leader peptide and pro-segment as they lead to full or partial mistargeting of the mutated proteins to mitochondria.
Thu Jun 01 00:00:00 UTC 2023
Developmental emergence of sleep rhythms enables long-term memory in Drosophila.
Science advances
Poe AR,Zhu L,Szuperak M,McClanahan PD,Anafi RC,Scholl B,Thum AS,Cavanaugh DJ,Kayser MS
A-11122 was used in Immunohistochemistry-immunofluorescence to identify the precise developmental time point when the clock begins to regulate sleep in Drosophila, leading to emergence of sleep rhythms in early third-instars (L3).
Fri Sep 08 00:00:00 UTC 2023
Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen Y,Xu Z,Chen J,Qiu Y,Yuan L,Liu P,Duan J,Chen L,Chen Y
A-11122 was used in Immunohistochemistry to report that coronin 2B is a key protein that regulates neuronal migration through its ability to control the distribution of the actin cytoskeleton and its regulatory signaling protein Rac1 during the multipolar-bipolar transition in the intermediate zone, providing insights into the molecular machinery that drives the migration process of newborn neurons.
Wed Jan 11 00:00:00 UTC 2023
Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.
Nature communications
Fankhaenel M,Hashemi FSG,Mourao L,Lucas E,Hosawi MM,Skipp P,Morin X,Scheele CLGJ,Elias S
A-11122 was used in Western Blotting to establish Annexin A1 as an upstream cortical cue that regulates LGN to direct planar cell divisions during mammalian epithelial morphogenesis.
Wed Jan 11 00:00:00 UTC 2023
Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action.
Cell reports
Roth L,Johann K,Hönes GS,Oelkrug R,Wagner L,Hoffmann A,Krohn K,Moeller LC,Weiner J,Heiker JT,Klöting N,Tönjes A,Stumvoll M,Blüher M,Mittag J,Krause K
A-11122 was used in Western Blotting to identify Zfp423 as a key molecule that integrates TH signaling into the regulation of adipose tissue plasticity.
Tue Feb 28 00:00:00 UTC 2023
The TNFR Wengen regulates the FGF pathway by an unconventional mechanism.
Nature communications
Letizia A,Espinàs ML,Giannios P,Llimargas M
A-11122 was used in Immunohistochemistry to propose that, in the tracheal context, Wengen interacts with Breathless to regulate its activity, and suggest that such unconventional mechanism, involving binding by TNFRs to unrelated proteins, may be a general strategy of TNFRs.
Thu Sep 21 00:00:00 UTC 2023
Germline protein, Cup, non-cell autonomously limits migratory cell fate in Drosophila oogenesis.
PLoS genetics
Saha B,Acharjee S,Ghosh G,Dasgupta P,Prasad M
A-11122 was used in Immunocytochemistry-immunofluorescence to propose that germline Cup functions through Notch and JAK-STAT to modulate BC fate specification from their static epithelial progenitors.
Wed Feb 01 00:00:00 UTC 2023
Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging.
iScience
Bebelman MP,Setiawan IM,Bergkamp ND,van Senten JR,Crudden C,Bebelman JPM,Verweij FJ,van Niel G,Siderius M,Pegtel DM,Smit MJ
A-11122 was used in Immunocytochemistry-immunofluorescence to suggest that exosomal release of US28 contributes to chemokine scavenging and immune evasion by human cytomegalovirus.
Fri Aug 18 00:00:00 UTC 2023
Bipotent transitional liver progenitor cells contribute to liver regeneration.
Nature genetics
Pu W,Zhu H,Zhang M,Pikiolek M,Ercan C,Li J,Huang X,Han X,Zhang Z,Lv Z,Li Y,Liu K,He L,Liu X,Heim MH,Terracciano LM,Tchorz JS,Zhou B
A-11122 was used in Immunohistochemistry to identify a transitional liver progenitor cell (TLPC), which originates from biliary epithelial cells and differentiates into hepatocytes during regeneration from severe liver injury.
Sat Apr 01 00:00:00 UTC 2023
Neural stem cells and oligodendrocyte progenitor cells compete for remyelination in the corpus callosum.
Frontiers in cellular neuroscience
Moyon S,Holloman M,Salzer JL
A-11122 was used in Immunohistochemistry to suggest that pOPCs and NSC-progeny compete to remyelinate the same axons.
Mon Sep 25 00:00:00 UTC 2023
An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2.
Nature communications
Harvest CK,Abele TJ,Yu C,Beatty CJ,Amason ME,Billman ZP,DePrizio MA,Souza FW,Lacey CA,Maltez VI,Larson HN,McGlaughon BD,Saban DR,Montgomery SA,Miao EA
A-11122 was used in Immunohistochemistry to discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum.
Sat Oct 21 00:00:00 UTC 2023
Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster.
Scientific reports
Corthals K,Andersson V,Churcher A,Reimegård J,Enjin A
A-11122 was used in Immunohistochemistry to unravel the molecular profile of the hygrosensory, and closely related thermosensory, systems in the vinegar fly Drosophila melanogaster.
Thu Sep 14 00:00:00 UTC 2023
Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty.
Nature communications
Molina-Gil S,Sotillos S,Espinosa-Vázquez JM,Almudi I,Hombría JC
A-11122 was used in Immunohistochemistry to propose that recently co-opted networks become interlocked, so that any change to the network because of its function in one organ, will be mirrored by other organs even if it provides no selective advantage to them.
Fri Sep 15 00:00:00 UTC 2023
BLZ8 activates a plastidial peroxiredoxin and a ferredoxin to protect Chlamydomonas reinhardtii against oxidative stress.
Plant biology (Stuttgart, Germany)
Choi BY,Park H,Kim J,Wang S,Lee J,Lee Y,Shim D
A-11122 was used in Western Blot to suggest that BLZ8 activates PRX1 and FDX5 expression, resulting in the detoxification of ROS to confer oxidative stress tolerance in microalgae.
Sun Oct 01 00:00:00 UTC 2023
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.
Nature communications
Cigliola V,Shoffner A,Lee N,Ou J,Gonzalez TJ,Hoque J,Becker CJ,Han Y,Shen G,Faw TD,Abd-El-Barr MM,Varghese S,Asokan A,Poss KD
A-11122 was used in Immunohistochemistry to identify Hb-egf as a neurogenic factor necessary for innate spinal cord regeneration and suggest strategies to improve spinal cord repair in mammals.
Fri Aug 11 00:00:00 UTC 2023
MicroRNA-650 Regulates the Pathogenesis of Alzheimer's Disease Through Targeting Cyclin-Dependent Kinase 5.
Molecular neurobiology
Lin L,Liu X,Cheng X,Li Y,Gearing M,Levey A,Huang X,Li Y,Jin P,Li X
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to show that miR-650 is able to significantly reduce the expression of APOE, PSEN1, and CDK5 in vitro and significantly alter the CDK5 level and ameliorate AD pathologies in APP-PSEN1 transgenic mice.
Mon May 01 00:00:00 UTC 2023
Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration.
BMC genomics
Garcia-Vaquero ML,Heim M,Flix B,Pereira M,Palin L,Marques TM,Pinto FR,de Las Rivas J,Voigt A,Besse F,Gama-Carvalho M
A-11122 was used in Immunohistochemistry to explain the common motor neuron phenotype.
Wed Sep 27 00:00:00 UTC 2023
Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain.
Acta neuropathologica communications
Wang PY,Kuo TY,Wang LH,Liang WH,Wang GS
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to support that impaired MBNL1-mediated retrograde BDNF-TrkB signaling may contribute to the histopathological phenotypes of DM1.
Wed Mar 15 00:00:00 UTC 2023
Inducible and Conditional Activation of Adult Neurogenesis Rescues Cadmium-Induced Hippocampus-Dependent Memory Deficits in ApoE4-KI Mice.
International journal of molecular sciences
Matsushita MT,Wang H,Abel GM,Xia Z
A-11122 was used in Immunohistochemistry to provide evidence for a direct link between impaired spatial memory and adult neurogenesis in this GxE model.
Tue May 23 00:00:00 UTC 2023
Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses.
Cell death & disease
Raccosta L,Marinozzi M,Costantini S,Maggioni D,Ferreira LM,Corna G,Zordan P,Sorice A,Farinello D,Bianchessi S,Riba M,Lazarevic D,Provero P,Mack M,Bondanza A,Nalvarte I,Gustafsson JA,Ranzani V,De Sanctis F,Ugel S,Baron S,Lobaccaro JA,Pontini L,Pacciarini M,Traversari C,Pagani M,Bronte V,Sitia G,Antonson P,Brendolan A,Budillon A,Russo V
A-11122 was used in Immunohistochemistry to support a role for (oxy)sterol metabolism in shaping monocyte-to-DC differentiation, and in tumor antigen presentation critical for responsiveness to immunotherapy.
Wed Feb 15 00:00:00 UTC 2023
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration.
NPJ Regenerative medicine
Xiao C,Hou J,Wang F,Song Y,Zheng J,Luo L,Wang J,Ding W,Zhu X,Xiong JW
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that the Brg1-Kdm7aa-Notch axis in cardiac endothelial cells, including the endocardium, regulates myocardial proliferation and regeneration via modulating the H3K4me3 of the notch promoters in zebrafish.
Fri Apr 07 00:00:00 UTC 2023
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Nature communications
Spencer ZT,Ng VH,Benchabane H,Siddiqui GS,Duwadi D,Maines B,Bryant JM,Schwarzkopf A,Yuan K,Kassel SN,Mishra A,Pimentel A,Lebensohn AM,Rohatgi R,Gerber SA,Robbins DJ,Lee E,Ahmed Y
A-11122 was used in Immunohistochemistry to reveal an evolutionarily conserved mechanism that mediates Wnt/Wingless receptor stabilization and underlies the precise activation of signaling throughout the spatial range of the morphogen gradient.
Thu Oct 05 00:00:00 UTC 2023
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1.
Neuron
Ruiz de Almodovar C,Fabre PJ,Knevels E,Coulon C,Segura I,Haddick PCG,Aerts L,Delattin N,Strasser G,Oh WJ,Lange C,Vinckier S,Haigh J,Fouquet C,Gu C,Alitalo K,Castellani V,Tessier-Lavigne M,Chedotal A,Charron F,Carmeliet P
A-11122 was used in Immunohistochemistry to show that the prototypic angiogenic factor VEGF is secreted by the floor plate and is a chemoattractant for commissural axons in vitro and in vivo.
Wed Apr 19 00:00:00 UTC 2023
Sleep/wake changes in perturbational complexity in rats and mice.
iScience
Cavelli ML,Mao R,Findlay G,Driessen K,Bugnon T,Tononi G,Cirelli C
A-11122 was used in Immunohistochemistry to show that PCIst can reliably measure vigilance states in unresponsive animals and support the hypothesis that it is low when an OFF period disrupts causal interactions in cortical networks.
Fri Mar 17 00:00:00 UTC 2023
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.
Journal of neuroinflammation
Yin S,Ma XY,Sun YF,Yin YQ,Long Y,Zhao CL,Ma JW,Li S,Hu Y,Li MT,Hu G,Zhou JW
A-11122 was used in Immunohistochemistry to investigate the precise role of astrocytes in neuroinflammation.
Wed Sep 06 00:00:00 UTC 2023
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila.
Nature metabolism
Mi T,Mack JO,Koolmees W,Lyon Q,Yochimowitz L,Teng ZQ,Jiang P,Montell C,Zhang YV
A-11122 was used in Immunocytochemistry to identify a chloride channel named alkaliphile (Alka), which is both necessary and sufficient for aversive taste responses to basic food.
Wed Mar 01 00:00:00 UTC 2023
A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution.
eLife
Meissner GW,Nern A,Dorman Z,DePasquale GM,Forster K,Gibney T,Hausenfluck JH,He Y,Iyer NA,Jeter J,Johnson L,Johnston RM,Lee K,Melton B,Yarbrough B,Zugates CT,Clements J,Goina C,Otsuna H,Rokicki K,Svirskas RR,Aso Y,Card GM,Dickson BJ,Ehrhardt E,Goldammer J,Ito M,Kainmueller D,Korff W,Mais L,Minegishi R,Namiki S,Rubin GM,Sterne GR,Wolff T,Malkesman O
A-11122 was used in Immunohistochemistry to demonstrate the potential of NeuronBridge to rapidly and effectively identify neuron matches based on morphology across imaging modalities and datasets.
Thu Feb 23 00:00:00 UTC 2023
The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging.
Nature communications
Sun X,Shen J,Perrimon N,Kong X,Wang D
A-11122 was used in Immunohistochemistry to reveal a role of ENDOU-like endonucleases as negative regulator of lipolysis.
Fri Oct 06 00:00:00 UTC 2023
The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging.
Nature communications
Sun X,Shen J,Perrimon N,Kong X,Wang D
A-11122 was used in Immunohistochemistry to reveal a role of ENDOU-like endonucleases as negative regulator of lipolysis.
Fri Oct 06 00:00:00 UTC 2023
Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Abarkan M,Fois GR,Vouillac-Mendoza C,Ahmed SH,Guillem K
A-11122 was used in Immunohistochemistry to report that access to unusually high doses of nicotine (i.e., from 30 µg to 240 µg/kg/injection) for self-administration precipitated a rapid and robust escalation of nicotine intake and increased the motivation for the drug in rats.
Mon May 01 00:00:00 UTC 2023
Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Ko J,Kim J,Myeong J,Kwak M,So I
A-11122 was used in Western Blotting to demonstrate that TRPC4 self-regulates its activity by allowing Ca2+ ions into the cell and promoting the PIP2 hydrolyzing activity of PLCδ1.
Wed Mar 01 00:00:00 UTC 2023
Rescue of GM3 synthase deficiency by spatially controlled, rAAV-mediated ST3GAL5 delivery.
JCI insight
Yang H,Brown RH,Wang D,Strauss KA,Gao G
A-11122 was used in Immunohistochemistry-immunofluorescence to show that a first-generation rAAV-ST3GAL5 replacement vector using a ubiquitous promoter restored tissue ST3GAL5 expression and normalized cerebral gangliosides in patient-derived induced pluripotent stem cell neurons and brain tissue from St3gal5-KO mice but caused fatal hepatotoxicity when administered systemically.
Mon May 08 00:00:00 UTC 2023
Zebrafish pigment cells develop directly from persistent highly multipotent progenitors.
Nature communications
Subkhankulova T,Camargo Sosa K,Uroshlev LA,Nikaido M,Shriever N,Kasianov AS,Yang X,Rodrigues FSLM,Carney TJ,Bavister G,Schwetlick H,Dawes JHP,Rocco A,Makeev VJ,Kelsh RN
A-11122 was used in Immunohistochemistry to find that leukocyte tyrosine kinase early expression marks a multipotent stage, with signalling driving iridophore differentiation through repression of fate-specific transcription factors for other fates.
Mon Mar 06 00:00:00 UTC 2023
LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models.
Nature communications
Szabó Á,Vincze V,Chhatre AS,Jipa A,Bognár S,Varga KE,Banik P,Harmatos-Ürmösi A,Neukomm LJ,Juhász G
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal a role of glial LAP in the clearance of neuronal debris in vivo, with potential implications for the recovery of the injured nervous system.
Mon May 29 00:00:00 UTC 2023
Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee.
PLoS biology
Carcaud J,Otte M,Grünewald B,Haase A,Sandoz JC,Beye M
A-11122 was used in Immunohistochemistry to demonstrate robust neural responses to several bee pheromone odorants, key drivers of social behavior, in the LH.
Sun Jan 01 00:00:00 UTC 2023
Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.
Science advances
Schlienger S,Yam PT,Balekoglu N,Ducuing H,Michaud JF,Makihara S,Kramer DK,Chen B,Fasano A,Berardelli A,Hamdan FF,Rouleau GA,Srour M,Charron F
A-11122 was used in Western Blotting to show that Arhgef7 and Git1 are required for Netrin-1-mediated axon guidance and act as a multifunctional effector complex.
Fri May 12 00:00:00 UTC 2023
Sequential verification of exogenous protein production in OVA gene-targeted chicken bioreactors.
Poultry science
Kim YM,Shim JH,Park JS,Choi HJ,Jung KM,Lee KY,Park KJ,Han JY
A-11122 was used in Immunohistochemistry to evaluate the expression of EGFP protein in the oviduct, along with the physical properties of eggs and egg white from OVALBUMIN (OVA) EGFP knock-in hens.
Sun Jan 01 00:00:00 UTC 2023
Histone bivalency regulates the timing of cerebellar granule cell development.
Genes & development
Mätlik K,Govek EE,Paul MR,Allis CD,Hatten ME
A-11122 was used in Immunohistochemistry to analyze how chromatin modifications control gene expression in a specific type of CNS neuron: the mouse cerebellar granule cell (GC). We found that in proliferating GC progenitors (GCPs), H3K4me3/H3K27me3 bivalency is common at neuronal genes and undergoes dynamic changes that correlate with gene expression during migration and circuit formation.
Sat Jul 01 00:00:00 UTC 2023
Unique functional responses differentially map onto genetic subtypes of dopamine neurons.
Nature neuroscience
Azcorra M,Gaertner Z,Davidson C,He Q,Kim H,Nagappan S,Hayes CK,Ramakrishnan C,Fenno L,Kim YS,Deisseroth K,Longnecker R,Awatramani R,Dombeck DA
A-11122 was used in Immunohistochemistry to dissect dopaminergic functions.
Sun Oct 01 00:00:00 UTC 2023
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.
Progress in neurobiology
Denechaud M,Geurs S,Comptdaer T,Bégard S,Garcia-Núñez A,Pechereau LA,Bouillet T,Vermeiren Y,De Deyn PP,Perbet R,Deramecourt V,Maurage CA,Vanderhaegen M,Vanuytven S,Lefebvre B,Bogaert E,Déglon N,Voet T,Colin M,Buée L,Dermaut B,Galas MC
A-11122 was used in Immunohistochemistry to propose a tau-dependent protective effect of neuronal cell cycle reactivation in AD brains and challenges the current view that the neuronal cell cycle is an early mediator of tau pathology.
Sat Apr 01 00:00:00 UTC 2023
Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading.
eLife
Porter H,Li Y,Neguembor MV,Beltran M,Varsally W,Martin L,Cornejo MT,Pezić D,Bhamra A,Surinova S,Jenner RG,Cosma MP,Hadjur S
A-11122 was used in Immunocytochemistry to propose that SA1 takes advantage of structural R-loop platforms to link cohesin loading and chromatin structure with diverse functions.
Mon Apr 03 00:00:00 UTC 2023
Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading.
eLife
Porter H,Li Y,Neguembor MV,Beltran M,Varsally W,Martin L,Cornejo MT,Pezić D,Bhamra A,Surinova S,Jenner RG,Cosma MP,Hadjur S
A-11122 was used in Immunocytochemistry to propose that SA1 takes advantage of structural R-loop platforms to link cohesin loading and chromatin structure with diverse functions.
Mon Apr 03 00:00:00 UTC 2023
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion.
Frontiers in molecular neuroscience
Martínez-Mármol R,Muhaisen A,Cotrufo T,Roselló-Busquets C,Ros O,Hernaiz-Llorens M,Pérez-Branguli F,Andrés RM,Parcerisas A,Pascual M,Ulloa F,Soriano E
A-11122 was used in Western Blot to investigate whether Netrin-1-dependent growth cone collapse and chemorepulsion are associated with enhanced membrane internalization.
Tue Oct 31 00:00:00 UTC 2023
A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes.
Cells
Jia Y,Reboulet J,Gillet B,Hughes S,Forcet C,Tribollet V,Hajj Sleiman N,Kundlacz C,Vanacker JM,Bleicher F,Merabet S
A-11122 was used in Western Blotting to demonstrate that the Cell-PCA was pertinent for revealing and, importantly, comparing the interactomes of different or highly related bait proteins in the same cell context.
Tue Jan 03 00:00:00 UTC 2023
Spatially controlled construction of assembloids using bioprinting.
Nature communications
Roth JG,Brunel LG,Huang MS,Liu Y,Cai B,Sinha S,Yang F,Pașca SP,Shin S,Heilshorn SC
A-11122 was used in Immunohistochemistry to demonstrate the potential for the SPOT platform to construct assembloids which recapitulate key developmental processes and disease etiologies.
Wed Jul 19 00:00:00 UTC 2023
The nanoscale organization of reticulon 4 shapes local endoplasmic reticulum structure in situ.
The Journal of cell biology
Fuentes LA,Marin Z,Tyson J,Baddeley D,Bewersdorf J
A-11122 was used in Western Blot to investigate how the endoplasmic reticulum(ER)-membrane curving protein reticulon 4 (Rtn4) localizes to and organizes in the membrane and how that affects the local ER structure.
Mon Oct 02 00:00:00 UTC 2023
SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome.
RNA biology
Shehata SI,Parker R
A-11122 was used in Immunohistochemistry-immunofluorescence to perform mutational analyses of Nsp1, and these revealed that both the N and C terminal domains of Nsp1 are important for translational repression.
Sun Jan 01 00:00:00 UTC 2023
String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration.
Disease models & mechanisms
Oliveira AC,Santos M,Pinho M,Lopes CS
A-11122 was used in Immunohistochemistry to provide evidence that Stg/Cdc25 reduces Tau phosphorylation levels independently of Tau aggregation status and delays neurodegeneration progression in the fly.
Sun Jan 01 00:00:00 UTC 2023
String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration.
Disease models & mechanisms
Oliveira AC,Santos M,Pinho M,Lopes CS
A-11122 was used in Immunohistochemistry to provide evidence that Stg/Cdc25 reduces Tau phosphorylation levels independently of Tau aggregation status and delays neurodegeneration progression in the fly.
Sun Jan 01 00:00:00 UTC 2023
Glial progenitor cells of the adult human white and grey matter are contextually distinct.
Glia
Osorio MJ,Mariani JN,Zou L,Schanz SJ,Heffernan K,Cornwell A,Goldman SA
A-11122 was used in Immunohistochemistry to suggest that human grey and white matter GPCs comprise context-specific pools with distinct functional biases.
Wed Mar 01 00:00:00 UTC 2023
FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.
Scientific reports
Shimizu H,Hohjoh H
A-11122 was used in Western Blotting to provide new insights into the regulatory mechanism of the ubiquitin-proteasome system (UPS) and into the interpretation of the pathogenesis of diseases in which these genes are involved as UPS-related factors.
Thu Feb 02 00:00:00 UTC 2023
Base editing rescue of spinal muscular atrophy in cells and in mice.
Science (New York, N.Y.)
Arbab M,Matuszek Z,Kray KM,Du A,Newby GA,Blatnik AJ,Raguram A,Richter MF,Zhao KT,Levy JM,Shen MW,Arnold WD,Wang D,Xie J,Gao G,Burghes AHM,Liu DR
A-11122 was used in Immunohistochemistry to demonstrate the potential of a one-time base editing treatment for SMA.
Fri Apr 21 00:00:00 UTC 2023
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei.
Nature communications
Zhu J,Chen K,Sun YH,Ye W,Liu J,Zhang D,Su N,Wu L,Kou X,Zhao Y,Wang H,Gao S,Kang L
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to reveal that accurate histone variant incorporation and incidental modifications in parental pronuclei are specified by LSM1-dependent pericentromeric RNA decay.
Tue Feb 21 00:00:00 UTC 2023
BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.
Science advances
Ghouil R,Miron S,Sato K,Ristic D,van Rossum-Fikkert SE,Legrand P,Ouldali M,Winter JM,Ropars V,David G,Arteni AA,Wyman C,Knipscheer P,Kanaar R,Zelensky AN,Zinn-Justin S
A-11122 was used in Western Blot to propose that, during meiosis, the control of HSF2BP-BRCA2 oligomerization by BRME1 ensures timely assembly of the ring complex that concentrates BRCA2 and controls its turnover, thus promoting HR.
Fri Oct 27 00:00:00 UTC 2023
Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.
Journal of cell science
Komori T,Kuwahara T,Fujimoto T,Sakurai M,Koyama-Honda I,Fukuda M,Iwatsubo T
A-11122 was used in Immunocytochemistry and Western Blotting to report a novel phosphorylation in Rab29 that is not mediated by LRRK2 and occurs under lysosomal overload stress.
Sat Jul 15 00:00:00 UTC 2023
Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.
Journal of cell science
Komori T,Kuwahara T,Fujimoto T,Sakurai M,Koyama-Honda I,Fukuda M,Iwatsubo T
A-11122 was used in Immunocytochemistry and Western Blotting to report a novel phosphorylation in Rab29 that is not mediated by LRRK2 and occurs under lysosomal overload stress.
Sat Jul 15 00:00:00 UTC 2023
Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
Proceedings of the National Academy of Sciences of the United States of America
Mun DJ,Goo BS,Suh BK,Hong JH,Woo Y,Kim SJ,Kim S,Lee SB,Won Y,Yoo JY,Cho E,Jang EJ,Nhung TTM,Triet HM,An H,Lee H,Nguyen MD,Park SY,Baek ST,Park SK
A-11122 was used in Immunocytochemistry and Western Blotting to propose that the Gcap14-Ndel1 complex is fundamental for cytoskeletal remodeling during neurodevelopmental processes such as neuronal processes elongation and neuronal migration.
Tue Feb 21 00:00:00 UTC 2023
Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
Proceedings of the National Academy of Sciences of the United States of America
Mun DJ,Goo BS,Suh BK,Hong JH,Woo Y,Kim SJ,Kim S,Lee SB,Won Y,Yoo JY,Cho E,Jang EJ,Nhung TTM,Triet HM,An H,Lee H,Nguyen MD,Park SY,Baek ST,Park SK
A-11122 was used in Immunocytochemistry and Western Blotting to propose that the Gcap14-Ndel1 complex is fundamental for cytoskeletal remodeling during neurodevelopmental processes such as neuronal processes elongation and neuronal migration.
Tue Feb 21 00:00:00 UTC 2023
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center.
Cell
Grootveld AK,Kyaw W,Panova V,Lau AWY,Ashwin E,Seuzaret G,Dhenni R,Bhattacharyya ND,Khoo WH,Biro M,Mitra T,Meyer-Hermann M,Bertolino P,Tanaka M,Hume DA,Croucher PI,Brink R,Nguyen A,Bannard O,Phan TG
A-11122 was used in Immunocytochemistry to investigate if Tingible body macrophages derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle.
Thu Mar 16 00:00:00 UTC 2023
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.
EMBO reports
Kwon M,Lee JH,Yoon Y,Pleasure SJ,Yoon K
A-11122 was used in Immunohistochemistry to show that CRHR1 is required for the maintenance of neural stem cell properties, as assessed by in vitro neurosphere assays and cell distribution in the embryonic cortical layers following in utero electroporation.
Mon Feb 06 00:00:00 UTC 2023
Differentiation Capacity of Porcine Skeletal Muscle-Derived Stem Cells as Intermediate Species between Mice and Humans.
International journal of molecular sciences
Tamaki T,Natsume T,Katoh A,Nakajima N,Saito K,Fukuzawa T,Otake M,Enya S,Kangawa A,Imai T,Tamaki M,Uchiyama Y
A-11122 was used in Immunohistochemistry to conclude that Sk-34 and Sk-DN cells in pigs are closer to those in humans than to those in mice.
Wed Jun 07 00:00:00 UTC 2023
Synthetic Assembly DNA Cloning to Build Plasmids for Multiplexed Transgenic Selection, Counterselection or Any Other Genetic Strategies Using Drosophila melanogaster.
Current protocols
Venken KJT,Matinyan N,Gonzalez Y,Sarrion-Perdigones A,Dierick HA
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to demonstrate the functionality of these plasmids by including the expression pattern obtained after co-injection, followed by co-selection using G418 sulfate and blasticidin S, resulting in co-transgenesis of both plasmids.
Wed Feb 01 00:00:00 UTC 2023
Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.
Cell reports
Nagai Y,Kisaka Y,Nomura K,Nishitani N,Andoh C,Koda M,Kawai H,Seiriki K,Nagayasu K,Kasai A,Shirakawa H,Nakazawa T,Hashimoto H,Kaneko S
A-11122 was used in Immunohistochemistry (Frozen) to identify a role of dorsal raphe nucleus 5-HT neurons as specific reactivators of positive memories and provides insights into how serotonin elicits antidepressive effects.
Tue Mar 28 00:00:00 UTC 2023
The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II.
Nucleic acids research
Carnesecchi J,Boumpas P,van Nierop Y Sanchez P,Domsch K,Pinto HD,Borges Pinto P,Lohmann I
A-11122 was used in Western Blotting to uncover a novel role of the Hox TFs at the mRNA regulatory layer. This could be an essential function for other classes of TFs to control cell diversity.
Tue Jan 25 00:00:00 UTC 2022
A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.
Neuron
Wei XP,Collie M,Dempsey B,Fortin G,Yackle K
A-11122 was used in Immunohistochemistry to reveal that a novel mammalian brainstem oscillator embedded within the conserved breathing circuitry plays a central role in the production of neonatal vocalizations.
Wed Feb 16 00:00:00 UTC 2022
Valence opponency in peripheral olfactory processing.
Proceedings of the National Academy of Sciences of the United States of America
Wu ST,Chen JY,Martin V,Ng R,Zhang Y,Grover D,Greenspan RJ,Aljadeff J,Su CY
A-11122 was used in Immunohistochemistry to suggest that this organization likely contributes to processing ratio information in odor mixtures.
Tue Feb 01 00:00:00 UTC 2022
Olfactory stimuli and moonwalker SEZ neurons can drive backward locomotion in Drosophila.
Current biology : CB
Israel S,Rozenfeld E,Weber D,Huetteroth W,Parnas M
A-11122 was used in Immunohistochemistry to reveal an important modality input to MDNs, a novel set of neurons presynaptic to MDNs driving backward locomotion and an MDN-independent backward locomotion pathway.
Mon Mar 14 00:00:00 UTC 2022
Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility.
Current biology : CB
Horard B,Terretaz K,Gosselin-Grenet AS,Sobry H,Sicard M,Landmann F,Loppin B
A-11122 was used in Immunohistochemistry to the mechanism by which Wolbachia CI factor genes control the fate of paternal chromosomes at fertilization.
Mon Mar 28 00:00:00 UTC 2022
Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction.
Current biology : CB
Duckhorn JC,Cande J,Metkus MC,Song H,Altamirano S,Stern DL,Shirangi TR
A-11122 was used in Immunohistochemistry to report the pattern of expression of the dissatisfaction (dsf) gene in the central nervous system and show that the activity of sexually dimorphic abdominal interneurons that co-express dsf and doublesex (dsx) is necessary and sufficient for vaginal plate opening in virgin females, ovipositor extrusion in mated females, and abdominal curling in males during courtship.
Mon Apr 25 00:00:00 UTC 2022
Integrated analysis of Wnt signalling system component gene expression.
Development (Cambridge, England)
Murphy P,Armit C,Hill B,Venkataraman S,Frankel P,Baldock RA,Davidson DR
A-11122 was used in Immunocytochemistry-immunoflourescence to report an integrated analysis of key encoding genes in the 3D space of the mouse embryo across multiple stages of development.
Mon Aug 15 00:00:00 UTC 2022
Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pop IV,Espinosa F,Blevins CJ,Okafor PC,Ogujiofor OW,Goyal M,Mona B,Landy MA,Dean KM,Gurumurthy CB,Lai HC
A-11122 was used in Western Blotting to define the unique anatomic trajectories of long-range direct and indirect spinocerebellar pathways as well as local intersegmental spinal circuits using genetic tools in both male and female mice.
Wed Jan 26 00:00:00 UTC 2022
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zotter B,Dagan O,Brady J,Baloui H,Samanta J,Salzer JL
A-11122 was used in Immunohistochemistry-immunofluorescence to delineate how peripheral nerves acquire their distinctive organization during normal development, and highlight mechanisms that may regulate their reorganization in pathologic settings, including peripheral neuropathies and nerve injury.
Wed Jan 12 00:00:00 UTC 2022
Ankyrin-R Links Kv3.3 to the Spectrin Cytoskeleton and Is Required for Purkinje Neuron Survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stevens SR,van der Heijden ME,Ogawa Y,Lin T,Sillitoe RV,Rasband MN
A-11122 was used in Western Blotting to investigate if Ankyrin scaffolding proteins localize and stabilize ion channels in the membrane by linking them to the spectrin-based cytoskeleton.
Wed Jan 05 00:00:00 UTC 2022
Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Estévez-Silva HM,Cuesto G,Romero N,Brito-Armas JM,Acevedo-Arozena A,Acebes Á,Marcellino DJ
A-11122 was used in Immunocytochemistry-immunoflourescence to evaluate the abilities of ACR16 and PRE-084 to induce new synapses and spines formation, analyzing the expression of the possible genes and proteins involved.
Thu Sep 01 00:00:00 UTC 2022
Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Structure (London, England : 1993)
Rosa E Silva I,Binó L,Johnson CM,Rutherford TJ,Neuhaus D,Andreeva A,Čajánek L,van Breugel M
A-11122 was used in Western Blot to present a detailed biochemical, structural, and functional analysis of the CEP164-TTBK2 complex and demonstrate how it is compromised by two ciliopathic mutations in the centriole distal appendage component CEP164.
Thu Jan 06 00:00:00 UTC 2022
Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.
Disease models & mechanisms
Hyun SA,Ko MY,Jang S,Lee BS,Rho J,Kim KK,Kim WY,Ka M
A-11122 was used in Immunohistochemistry to provide molecular mechanistic insights into anatomical and physiological neurotoxic consequences related to a potent endocrine modifier.
Fri Jul 01 00:00:00 UTC 2022
Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis.
Disease models & mechanisms
Pulianmackal AJ,Kanakousaki K,Flegel K,Grushko OG,Gourley E,Rozich E,Buttitta LA
A-11122 was used in Immunohistochemistry to suggest that partial loss of Nup98-96 function in translocations could de-regulate protein synthesis, leading to signaling that cooperates with other mutations to promote tumorigenesis.
Tue Mar 01 00:00:00 UTC 2022
Deficiency in coatomer complex I causes aberrant activation of STING signalling.
Nature communications
Steiner A,Hrovat-Schaale K,Prigione I,Yu CH,Laohamonthonkul P,Harapas CR,Low RRJ,De Nardo D,Dagley LF,Mlodzianoski MJ,Rogers KL,Zillinger T,Hartmann G,Gantier MP,Gattorno M,Geyer M,Volpi S,Davidson S,Masters SL
A-11122 was used in Western Blotting to suggest targeted inhibition of the cGAS/STING pathway as a promising therapeutic approach.
Thu Apr 28 00:00:00 UTC 2022
Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems.
Cells
Burkard T,Proske N,Resner K,Collignon L,Knegendorf L,Friesland M,Verhoye L,Sayed IM,Brüggemann Y,Nocke MK,Behrendt P,Wedemeyer H,Meuleman P,Todt D,Steinmann E
A-11122 was used in Immunocytochemistry-immunofluorescence to provide new insights into the pathogenesis of HCV-HEV co-infections and should contribute to its clinical management in the future.
Tue Mar 08 00:00:00 UTC 2022
Higher-order unimodal olfactory sensory preconditioning in Drosophila.
eLife
Martinez-Cervantes J,Shah P,Phan A,Cervantes-Sandoval I
A-11122 was used in Immunohistochemistry-immunofluorescence to indicate that flies can infer value to olfactory stimuli based on the previous associative structure between odors, and that inhibition of Rac1 lengthens the time window of the olfactory 'sensory buffer', allowing the establishment of associations between odors presented in sequence.
Wed Sep 21 00:00:00 UTC 2022
RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Science advances
Akturk A,Day M,Tarchini B
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to suggest that polarized guanine nucleotide exchange factor/GTPase-activating protein junctional activity might dissociate heterotrimeric G proteins, generating free GNAI(GDP) for GPSM2 at the adjacent apical membrane.
Fri Oct 21 00:00:00 UTC 2022
RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Science advances
Akturk A,Day M,Tarchini B
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to suggest that polarized guanine nucleotide exchange factor/GTPase-activating protein junctional activity might dissociate heterotrimeric G proteins, generating free GNAI(GDP) for GPSM2 at the adjacent apical membrane.
Fri Oct 21 00:00:00 UTC 2022
TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model.
The Journal of investigative dermatology
Beattie K,Jiang H,Gautam M,MacVittie MK,Miller B,Ma M,Liu Q,Luo W
A-11122 was used in Immunohistochemistry-immunofluorescence to identify a role of TrpC3 and NP1 afferents in contact dermatitis pathology.
Fri Apr 01 00:00:00 UTC 2022
Identification of novel split-GAL4 drivers for the characterization of enteroendocrine cells in the Drosophila melanogaster midgut.
G3 (Bethesda, Md.)
Holsopple JM,Cook KR,Popodi EM
A-11122 was used in Immunohistochemistry-immunofluorescence to identify additional split-GAL4 drivers that promote expression in discrete subpopulations of enteroendocrine cells.
Mon May 30 00:00:00 UTC 2022
Nonsynaptic Transmission Mediates Light Context-Dependent Odor Responses in Drosophila melanogaster.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ikeda K,Kataoka M,Tanaka NK
A-11122 was used in Immunohistochemistry to show that field potential changes in retinae evoked by a sensory stimulus can control the excitability of distant neurons in vivo and mediates multimodal sensory integration in Drosophila melanogaster As such ephaptic transmission is more effective at a short distance, the ephaptic transmission from the retinae may contribute significantly to firing rate changes in downstream neurons of the photoreceptor cells in the optic lobe.
Wed Nov 16 00:00:00 UTC 2022
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
Nature communications
Xie YX,Naseri NN,Fels J,Kharel P,Na Y,Lane D,Burré J,Sharma M
A-11122 was used in Immunohistochemistry to propose lysosomal exocytosis as a central mechanism for the release of aggregated and degradation-resistant proteins from neurons.
Mon Aug 22 00:00:00 UTC 2022
Hippocampus as a sorter and reverberatory integrator of sensory inputs.
Nature communications
Nomoto M,Murayama E,Ohno S,Okubo-Suzuki R,Muramatsu SI,Inokuchi K
A-11122 was used in Immunohistochemistry-immunofluorescence to find that synchrony between conditioned stimulus (CS)-, unconditioned stimulus (US)- and future retrieval-responsible cells occurs in the CA1 during the reverberatory phase that emerges after sensory inputs have ceased, but not during CS and US inputs.
Tue Dec 20 00:00:00 UTC 2022
Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation.
Development (Cambridge, England)
Biswas S,Shahriar S,Giangreco NP,Arvanitis P,Winkler M,Tatonetti NP,Brunken WJ,Cutforth T,Agalliu D
A-11122 was used in Immunohistochemistry to show that mural cells have active Wnt/β-catenin signaling during central nervous system development in mice.
Thu Sep 01 00:00:00 UTC 2022
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.
Nature communications
Kawai H,Bouchekioua Y,Nishitani N,Niitani K,Izumi S,Morishita H,Andoh C,Nagai Y,Koda M,Hagiwara M,Toda K,Shirakawa H,Nagayasu K,Ohmura Y,Kondo M,Kaneda K,Yoshioka M,Kaneko S
A-11122 was used in Immunohistochemistry to reveal an essential function of MRN serotonergic neurons, including 5-HTMRN?IPN, in the processing of reward and aversive stimuli.
Thu Dec 22 00:00:00 UTC 2022
Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants.
Frontiers in neuroscience
Kasture AS,Fischer FP,Kunert L,Burger ML,Burgstaller AC,El-Kasaby A,Hummel T,Sucic S
A-11122 was used in Immunohistochemistry-immunofluorescence to identify three compounds (chemical and pharmacological chaperones) conferring moderate rescue capacity for several variants.
Wed Dec 11 00:00:00 UTC 2024
The impact of storage on extracellular vesicles: A systematic study.
Journal of extracellular vesicles
Gelibter S,Marostica G,Mandelli A,Siciliani S,Podini P,Finardi A,Furlan R
A-11122 was used in Western Blotting to show a significant impact of storage on EVs samples in terms of particle loss, purity reduction and fusion phenomena leading to artefactual particles.
Tue Feb 01 00:00:00 UTC 2022
Early developmental, meiosis-specific proteins - Spo11, Msh4-1, and Msh5 - Affect subsequent genome reorganization in Paramecium tetraurelia.
Biochimica et biophysica acta. Molecular cell research
Rzeszutek I,Swart EC,Pabian-Jewuła S,Russo A,Nowacki M
A-11122 was used in Immunocytochemistry-immunofluorescence to understand no coding RNA in Paramecium sexual reproduction.
Wed Jun 01 00:00:00 UTC 2022
A conserved sequence in the small intracellular loop of tetraspanins forms an M-shaped inter-helix turn.
Scientific reports
Reppert N,Lang T
A-11122 was used in Western Blot to explore the small intracellular loop between transmembrane segment 2 and 3 in tetraspanins.
Wed Mar 16 00:00:00 UTC 2022
A circular RNA Edis-Relish-castor axis regulates neuronal development in Drosophila.
PLoS genetics
Liu W,Liang W,Xiong XP,Li JL,Zhou R
A-11122 was used in Immunohistochemistry to conclude that the circular RNA Edis acts through Relish and castor to regulate neuronal development.
Sat Oct 01 00:00:00 UTC 2022
ORP5/8 and MIB/MICOS link ER-mitochondria and intra-mitochondrial contacts for non-vesicular transport of phosphatidylserine.
Cell reports
Monteiro-Cardoso VF,Rochin L,Arora A,Houcine A,Jääskeläinen E,Kivelä AM,Sauvanet C,Le Bars R,Marien E,Dehairs J,Neveu J,El Khallouki N,Santonico E,Swinnen JV,Tareste D,Olkkonen VM,Giordano F
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to reveal a physical and functional link between ER-mitochondria contacts involved in lipid transfer and intra-mitochondrial membrane contacts maintained by the MIB/MICOS complexes.
Tue Sep 20 00:00:00 UTC 2022
The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
eLife
Yang S,Wu X,Daoutidou EI,Zhang Y,Shimell M,Chuang KH,Peterson AJ,O'Connor MB,Zheng X
A-11122 was used in Immunocytochemistry to propose that Hh-induced Nord expression fine-tunes both the range and strength of BMP signaling in the developing Drosophila wing.
Mon Jan 17 00:00:00 UTC 2022
The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics.
The Journal of biological chemistry
Francis V,Alshafie W,Kumar R,Girard M,Brais B,McPherson PS
A-11122 was used in Western Blot, Immunoprecipitation to investigate the molecular details of the function of sacsin.
Thu Sep 01 00:00:00 UTC 2022
The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics.
The Journal of biological chemistry
Francis V,Alshafie W,Kumar R,Girard M,Brais B,McPherson PS
A-11122 was used in Western Blot, Immunoprecipitation to investigate the molecular details of the function of sacsin.
Thu Sep 01 00:00:00 UTC 2022
Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus.
eLife
Somaiya RD,Stebbins K,Gingrich EC,Xie H,Campbell JN,Garcia ADR,Fox MA
A-11122 was used in Immunohistochemistry-immunofluorescence to identify a morphogen-dependent neuron-astrocyte signaling mechanism essential for the migration of thalamic interneurons.
Mon Nov 07 00:00:00 UTC 2022
Global Proximity Interactome of the Human Macroautophagy Pathway.
Autophagy
Tu YXI,Sydor AM,Coyaud E,Laurent EMN,Dyer D,Mellouk N,St-Germain J,Vernon RM,Forman-Kay JD,Li T,Hua R,Zhao K,Ridgway ND,Kim PK,Raught B,Brumell JH
A-11122 was used in Western Blotting to perform proximity-dependent biotin identification (BioID) on 39 core human macroautophagy proteins, identifying over 700 unique high confidence proximity interactors with new putative connections between macroautophagic and essential cellular processes.
Sun May 01 00:00:00 UTC 2022
Generation and Comparative Analysis of an Itga8-CreER Mouse with Preferential Activity in Vascular Smooth Muscle Cells.
Nature cardiovascular research
Warthi G,Faulkner JL,Doja J,Ghanam AR,Gao P,Yang AC,Slivano OJ,Barris CT,Kress TC,Zawieja SD,Griffin SH,Xie X,Ashworth A,Christie CK,Bryant WB,Kumar A,Davis MJ,Long X,Gan L,Belin de Chantemele EJ,Lyu Q,Miano JM
A-11122 was used in Western Blotting to present an Itga8-CreER T2 knock-in mouse and compare its activity with a Myh11-CreER T2 mouse.
Tue Nov 01 00:00:00 UTC 2022
Synaptic components are required for glioblastoma progression in Drosophila.
PLoS genetics
Losada-Pérez M,Hernández García-Moreno M,García-Ricote I,Casas-Tintó S
A-11122 was used in Immunohistochemistry to indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.
Fri Jul 01 00:00:00 UTC 2022
Structure and function differences in the prelimbic cortex to basolateral amygdala circuit mediate trait vulnerability in a novel model of acute social defeat stress in male mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Grossman YS,Fillinger C,Manganaro A,Voren G,Waldman R,Zou T,Janssen WG,Kenny PJ,Dumitriu D
A-11122 was used in Immunohistochemistry-immunofluorescence to support PL?BLA circuit overactivity during stress as a biomarker of trait vulnerability and potential target for prevention of stress-induced psychopathology.
Tue Feb 01 00:00:00 UTC 2022
GABAergic interneurons' feedback inhibition of dorsal raphe-projecting pyramidal neurons of the medial prefrontal cortex suppresses feeding of adolescent female mice undergoing activity-based anorexia.
Brain structure & function
Du M,Santiago A,Akiz C,Aoki C
A-11122 was used in Immunohistochemistry to propose that C21 activates two antagonistic pathways: (1) PFC→DR pyramidal neurons that promote food intake; and (2) GABA-IN in the mPFC that dampen food intake through feedback inhibition of mPFC→DR neurons.
Fri Jul 01 00:00:00 UTC 2022
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions.
Cell metabolism
Imbernon M,Saponaro C,Helms HCC,Duquenne M,Fernandois D,Deligia E,Denis RGP,Chao DHM,Rasika S,Staels B,Pattou F,Pfrieger FW,Brodin B,Luquet S,Bonner C,Prevot V
A-11122 was used in Immunohistochemistry (Free) to indicate that the liraglutide-induced activation of hypothalamic neurons and its downstream metabolic effects are mediated by its tanycytic transport into the mediobasal hypothalamus, strengthening the notion of tanycytes as key regulators of metabolic homeostasis.
Tue Jul 05 00:00:00 UTC 2022
Striatonigrostriatal circuit architecture for disinhibition of dopamine signaling.
Cell reports
Ambrosi P,Lerner TN
A-11122 was used in Immunohistochemistry to show that these synapses are unable to modulate tonic dopamine neuron firing, questioning the prominence of their role in mediating crosstalk between striatal subregions.
Tue Aug 16 00:00:00 UTC 2022
PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in Arabidopsis.
The New phytologist
Hu T,Manuela D,Hinsch V,Xu M
A-11122 was used in Western Blot to suggest that PKL associates with histone deacetylases to erase H3K27ac and promote PRC1 and PRC2 activities to mediate vegetative phase change and maintain plants in the adult phase after the phase transition.
Mon Aug 01 00:00:00 UTC 2022
A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration.
eLife
Brandão AS,Borbinha J,Pereira T,Brito PH,Lourenço R,Bensimon-Brito A,Jacinto A
A-11122 was used in Immunohistochemistry to indicate that metabolic alterations have a powerful instructive role in regulating genetic programs that dictate fate decisions and stimulate proliferation, thereby providing a deeper understanding on the mechanisms regulating blastema formation and bone regeneration.
Mon Aug 22 00:00:00 UTC 2022
The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Han C,Peng Q,Sun M,Jiang X,Su X,Chen J,Ma M,Zhu H,Ji X,Pan Y
A-11122 was used in Immunohistochemistry to reveal crucial roles of dsx, which is broadly conserved from worms to humans, in a small number of neurons in both sexes to establish dimorphic sexual and aggressive behaviors.
Tue Sep 13 00:00:00 UTC 2022
A descending pathway emanating from the periaqueductal gray mediates the development of cough-like hypersensitivity.
iScience
Chen Z,Lin MT,Zhan C,Zhong NS,Mu D,Lai KF,Liu MJ
A-11122 was used in Immunohistochemistry to show that GABAergic neurons in the lateral/ventrolateral periaqueductal gray suppress cough processing via a descending pathway.
Fri Jan 21 00:00:00 UTC 2022
The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance.
Genetics
Ariyapala IS,Buddika K,Hundley HA,Calvi BR,Sokol NS
A-11122 was used in Immunohistochemistry-immunofluorescence to indicate a nuclear role for Second Mitotic Wave Missing in adult stem cell maintenance, raising the possibility that nuclear post-transcriptional regulation of mRNAs encoding cell adhesion proteins ensures proper attachment of progenitor cells.
Fri Sep 30 00:00:00 UTC 2022
GPC3-Unc5 receptor complex structure and role in cell migration.
Cell
Akkermans O,Delloye-Bourgeois C,Peregrina C,Carrasquero-Ordaz M,Kokolaki M,Berbeira-Santana M,Chavent M,Reynaud F,Raj R,Agirre J,Aksu M,White ES,Lowe E,Ben Amar D,Zaballa S,Huo J,Pakos I,McCubbin PTN,Comoletti D,Owens RJ,Robinson CV,Castellani V,Del Toro D,Seiradake E
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate a conserved structural mechanism of cell guidance, where finely balanced Unc5-GPC3 interactions regulate cell migration.
Thu Oct 13 00:00:00 UTC 2022
Identification of Lsd1-interacting non-coding RNAs as regulators of fly oogenesis.
Cell reports
Shao TL,Ting RT,Lee MC
A-11122 was used in RNA Immunoprecipitation to present a physiological example of dynamic lncRNA-Lsd1 interplay that regulates stem cell/progenitor differentiation.
Tue Aug 30 00:00:00 UTC 2022
Distinct Encoding of Reward and Aversion by Peptidergic BNST Inputs to the VTA.
Frontiers in neural circuits
Soden ME,Yee JX,Cuevas B,Rastani A,Elum J,Zweifel LS
A-11122 was used in Immunohistochemistry to demonstrate additional diversification of the mesolimbic dopamine system through partially overlapping neuropeptidergic inputs.
Fri Jul 22 00:00:00 UTC 2022
The endoplasmic reticulum adopts two distinct tubule forms.
Proceedings of the National Academy of Sciences of the United States of America
Wang B,Zhao Z,Xiong M,Yan R,Xu K
A-11122 was used in Immunocytochemistry to uncover a dynamic structural dichotomy for ER tubules with intriguing functional implications.
Tue May 03 00:00:00 UTC 2022
Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging.
Nature methods
Chung KKH,Zhang Z,Kidd P,Zhang Y,Williams ND,Rollins B,Yang Y,Lin C,Baddeley D,Bewersdorf J
A-11122 was used in Immunocytochemistry-immunofluorescence to demonstrate a 26-fold increase in imaging speed over regular DNA-PAINT and show that our new implementation enables three-dimensional super-resolution DNA-PAINT imaging without optical sectioning.
Sun May 01 00:00:00 UTC 2022
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
Genome biology
Yuan S,Huang T,Bao Z,Wang S,Wu X,Liu J,Liu H,Chen ZJ
A-11122 was used in Immunocytochemistry to provide new insights into how histone modifications and their associated regulatory proteins collectively regulate meiotic homologous recombination.
Tue Sep 06 00:00:00 UTC 2022
Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain.
Pain
Arora V,Li T,Kumari S,Wang S,Asgar J,Chung MK
A-11122 was used in Immunohistochemistry to conclude that further understanding of TRPV1/Ca 2+ -dependent mechanisms of capsaicin-induced ablation and analgesia may help to improve the management of chronic pain.
Mon Aug 01 00:00:00 UTC 2022
The liver contains distinct interconnected networks of CX3CR1+ macrophages, XCR1+ type 1 and CD301a+ type 2 conventional dendritic cells embedded within portal tracts.
Immunology and cell biology
English K,Tan SY,Kwan R,Holz LE,Sierro F,McGuffog C,Kaisho T,Heath WR,MacDonald KP,McCaughan GW,Bowen DG,Bertolino P
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that portal tracts and their embedded cellular networks of myeloid cells form a distinctive lymphoid compartment in the liver that has the potential to orchestrate immune responses in this organ.
Fri Jul 01 00:00:00 UTC 2022
Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness.
eLife
Fanfone D,Wu Z,Mammi J,Berthenet K,Neves D,Weber K,Halaburkova A,Virard F,Bunel F,Jamard C,Hernandez-Vargas H,Tait SWG,Hennino A,Ichim G
A-11122 was used in Western Blot to show in vitro that migrating breast cancer cells develop resistance to anoikis following their passage through microporous membranes mimicking confined migration (CM), a mechanical constriction that cancer cells encounter during metastasis.
Tue Mar 08 00:00:00 UTC 2022
Cholinergic interneuron inhibition potentiates corticostriatal transmission in direct medium spiny neurons and rescues motor learning in parkinsonism.
Cell reports
Laverne G,Pesce J,Reynders A,Combrisson E,Gascon E,Melon C,Kerkerian-Le Goff L,Maurice N,Beurrier C
A-11122 was used in Immunohistochemistry to demonstrate that the control exerted by CINs on corticostriatal transmission and striatal-dependent motor-skill learning depends on the integrity of dopaminergic inputs.
Tue Jul 05 00:00:00 UTC 2022
Drosophila gustatory projections are segregated by taste modality and connectivity.
eLife
Engert S,Sterne GR,Bock DD,Scott K
A-11122 was used in Immunohistochemistry-immunofluorescence to resolve the anatomy of labellar gustatory projections, reveals that gustatory projections are segregated based on taste modality, and uncovers synaptic connections that may alter the transmission of gustatory signals.
Wed May 25 00:00:00 UTC 2022
TRPC3 channel gating by lipids requires localization at the ER/PM junctions defined by STIM1.
The Journal of cell biology
Liu H,Lin WY,Leibow SR,Morateck AJ,Ahuja M,Muallem S
A-11122 was used in Western Blotting to identify an FFAT site at the TRPC3 N-terminal loop within the linker helices that envelope the C-terminus pole helix.
Mon May 02 00:00:00 UTC 2022
Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling.
Kidney360
Finer G,Maezawa Y,Ide S,Onay T,Souma T,Scott R,Liang X,Zhao X,Gadhvi G,Winter DR,Quaggin SE,Hayashida T
A-11122 was used in Flow cytometry/Cell sorting to show that Tcf21 in Foxd1+ interstitial progenitors regulates stromal formation and differentiation via interaction with β-catenin.
Thu Jul 28 00:00:00 UTC 2022
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.
Nature communications
Paul A,Annunziato S,Lu B,Sun T,Evrova O,Planas-Paz L,Orsini V,Terracciano LM,Charlat O,Loureiro ZY,Ji L,Zamponi R,Sigoillot F,Lei H,Lindeman A,Russ C,Reece-Hoyes JS,Nicholson TB,Tchorz JS,Cong F
A-11122 was used in Immunoprecipitation to suggest that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway through sensing cell-cell interaction and recruiting SAV1 to cell-cell contact sites.
Thu Feb 17 00:00:00 UTC 2022
Proteomic and functional analyses of the periodic membrane skeleton in neurons.
Nature communications
Zhou R,Han B,Nowak R,Lu Y,Heller E,Xia C,Chishti AH,Fowler VM,Zhuang X
A-11122 was used in Immunohistochemistry to provide insights into the interactome of the MPS and suggest previously unknown functions of the MPS in neurons.
Thu Jun 09 00:00:00 UTC 2022
ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites.
The Journal of cell biology
Guyard V,Monteiro-Cardoso VF,Omrane M,Sauvanet C,Houcine A,Boulogne C,Ben Mbarek K,Vitale N,Faklaris O,El Khallouki N,Thiam AR,Giordano F
A-11122 was used in Immunocytochemistry-immunofluorescence to find that ORP5/8 regulates seipin recruitment to these MAM-LD contacts, and their loss impairs LD biogenesis.
Mon Sep 05 00:00:00 UTC 2022
A Non-Nuclear NF-κB Modulates Alcohol Sensitivity But Not Immunity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wijesekera TP,Wu Z,Stephens NP,Godula R,Lew LK,Atkinson NS
A-11122 was used in Immunohistochemistry to demonstrate that, in Drosophila melanogaster, NF-κB action is important both inside and outside the nucleus and that the Dif gene has segregated nuclear and non-nuclear NF-κB action into different protein isoforms.
Wed Apr 20 00:00:00 UTC 2022
Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line.
Frontiers in cellular neuroscience
Coffin AB,Dale E,Doppenberg E,Fearington F,Hayward T,Hill J,Molano O
A-11122 was used in Immunohistochemistry-immunofluorescence to identify drugs with the fewest side-effects and determine which therapies warrant audiometric monitoring.
Sat Sep 28 00:00:00 UTC 2024
A tumor-suppressive function for Notch3 in the parous mammary gland.
Development (Cambridge, England)
Chung WC,Egan SE,Xu K
A-11122 was used in Immunohistochemistry to report on Notch3 expression and functional analysis in the mouse mammary gland.
Sat Oct 01 00:00:00 UTC 2022
A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.
Nature communications
Suzuki A,Kosugi S,Murayama E,Sasakawa E,Ohkawa N,Konno A,Hirai H,Inokuchi K
A-11122 was used in Immunohistochemistry to conclude that a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.
Tue Jan 11 00:00:00 UTC 2022
General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala.
Frontiers in behavioral neuroscience
Kim IT,Farb C,Hou M,Prasad S,Talley E,Cook S,Campese VD
A-11122 was used in Immunocytochemistry-immunofluorescence to validate a role of central amygdala in producing aversive Pavlovian-instrumental transfer.
Sat Jul 16 00:00:00 UTC 2022
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Immunity
Dong X,Limjunyawong N,Sypek EI,Wang G,Ortines RV,Youn C,Alphonse MP,Dikeman D,Wang Y,Lay M,Kothari R,Vasavda C,Pundir P,Goff L,Miller LS,Lu W,Garza LA,Kim BS,Archer NK,Dong X
A-11122 was used in Western Blot to demonstrate the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining healthy skin ecology and promoting antibacterial host defense.
Tue Sep 13 00:00:00 UTC 2022
Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain.
Cancers
Parmigiani E,Giachino C
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that inactivation of Notch1 and Trp53 in cells with active Notch signaling is sufficient to induce brain tumor or hyperplasia formation.
Wed Nov 02 00:00:00 UTC 2022
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Nature communications
Khadka P,Reitman ZJ,Lu S,Buchan G,Gionet G,Dubois F,Carvalho DM,Shih J,Zhang S,Greenwald NF,Zack T,Shapira O,Pelton K,Hartley R,Bear H,Georgis Y,Jarmale S,Melanson R,Bonanno K,Schoolcraft K,Miller PG,Condurat AL,Gonzalez EM,Qian K,Morin E,Langhnoja J,Lupien LE,Rendo V,Digiacomo J,Wang D,Zhou K,Kumbhani R,Guerra Garcia ME,Sinai CE,Becker S,Schneider R,Vogelzang J,Krug K,Goodale A,Abid T,Kalani Z,Piccioni F,Beroukhim R,Persky NS,Root DE,Carcaboso AM,Ebert BL,Fuller C,Babur O,Kieran MW,Jones C,Keshishian H,Ligon KL,Carr SA,Phoenix TN,Bandopadhayay P
A-11122 was used in Immunohistochemistry to analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of its phosphatase are clonal driver events in 11% of Diffuse Midline Gliomas and are enriched in primary pontine tumors.
Tue Feb 01 00:00:00 UTC 2022
Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice.
Nature communications
Zhou K,Xu H,Lu S,Jiang S,Hou G,Deng X,He M,Zhu Y
A-11122 was used in Immunohistochemistry to elucidate the afferent-specific circuit architecture of the NAc in controlling reward and aversion.
Fri Oct 21 00:00:00 UTC 2022
Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein regulates cleavage furrow formation.
The Journal of cell biology
Sana S,Rajeevan A,Kotak S
A-11122 was used in Western Blot to establish that membrane compartmentalization of NuMA-based and Ect2-based complexes at the two distinct cell surfaces restricts dynein/dynactin and RhoA for coordinating spindle elongation with cleavage furrow formation.
Mon Dec 05 00:00:00 UTC 2022
Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation.
eLife
Thompson AF,Blackburn PR,Arons NS,Stevens SN,Babovic-Vuksanovic D,Lian JB,Klee EW,Stumpff J
A-11122 was used in Western Blotting to demonstrate the importance of both the head and tail of the motor in regulating the activity of KIF22 and offer insight into the cellular consequences of preventing KIF22 inactivation and disrupting force balance in anaphase.
Wed Jun 22 00:00:00 UTC 2022
Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity.
Current biology : CB
Buddika K,Huang YT,Ariyapala IS,Butrum-Griffith A,Norrell SA,O'Connor AM,Patel VK,Rector SA,Slovan M,Sokolowski M,Kato Y,Nakamura A,Sokol NS
A-11122 was used in Immunohistochemistry-immunofluorescence to identify a P-body-dependent repression activity that coordinates with known transcriptional repression programs to maintain a population of in vivo stem cells in a state primed for differentiation.
Mon Jan 24 00:00:00 UTC 2022
Characterization of lipoprotein lipase storage vesicles in 3T3-L1 adipocytes.
Journal of cell science
Roberts BS,Yang CQ,Neher SB
A-11122 was used in Immunocytochemistry to show that the LPL trafficking pathway shares some characteristics of these other pathways, but that LPL subcellular localization and trafficking are distinct from those of GLUT4 and leptin.
Tue Mar 01 00:00:00 UTC 2022
Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immunostaining.
RNA (New York, N.Y.)
Paramasivam P,Stöter M,Corradi E,Dalla Costa I,Höijer A,Bartesaghi S,Sabirsh A,Lindfors L,Yanez Arteta M,Nordberg P,Andersson S,Baudet ML,Bickle M,Zerial M
A-11122 was used in Immunohistochemistry-immunofluorescence to optimize cell fixation, permeabilization, and immunostaining of a number of organelle markers, achieving quantitative retention of mRNA and allowing visualization of levels that escape detection using conventional procedures.
Tue Mar 01 00:00:00 UTC 2022
Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures.
Progress in neurobiology
Wicker E,Hyder SK,Forcelli PA
A-11122 was used in Immunohistochemistry to highlight the particular importance of projections from mediodorsal nucleus to prelimbic cortex in the propagation of amygdala-kindled seizures.
Fri Jul 01 00:00:00 UTC 2022
Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database.
Cell reports
Rurak GM,Simard S,Freitas-Andrade M,Lacoste B,Charih F,Van Geel A,Stead J,Woodside B,Green JR,Coppola G,Salmaso N
A-11122 was used in Immunohistochemistry to find sex differences in gene expression patterns across development that peak at P7 and appear to result from males reaching a mature astroglial phenotype earlier than females.
Tue Feb 01 00:00:00 UTC 2022
TissUExM enables quantitative ultrastructural analysis in whole vertebrate embryos by expansion microscopy.
Cell reports methods
Steib E,Tetley R,Laine RF,Norris DP,Mao Y,Vermot J
A-11122 was used in Immunohistochemistry to conclude that TissUExM is ideal for performing ultrastructural studies and molecular mapping in situ in whole embryos.
Mon Oct 24 00:00:00 UTC 2022
Combining mass spectrometry and genetic labeling in mice to report TRP channel expression.
MethodsX
Wartenberg P,Lux F,Busch K,Fecher-Trost C,Wyatt A,Flockerzi V,Krasteva-Christ G,Boehm U,Weissgerber P
A-11122 was used in Immunohistochemistry to present an optimized method to visualize primary TRP-expressing cells with single cell resolution throughout the entire organism.
Tue Dec 27 00:00:00 UTC 2022
Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency.
Nature communications
Spina E,Simundza J,Incassati A,Chandramouli A,Kugler MC,Lin Z,Khodadadi-Jamayran A,Watson CJ,Cowin P
A-11122 was used in Immunohistochemistry to show that high Gpr125 expression identifies patients with particularly poor outcome within the basal breast cancer subtype highlighting its potential utility as a factor to stratify risk.
Thu Mar 17 00:00:00 UTC 2022
The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.
Nature communications
Platre MP,Satbhai SB,Brent L,Gleason MF,Cao M,Grison M,Glavier M,Zhang L,Gaillochet C,Goeschl C,Giovannetti M,Enugutti B,Neveu J,von Reth M,Alcázar R,Parker JE,Vert G,Bayer E,Busch W
A-11122 was used in Immunohistochemistry to report a receptor kinase SRF3, with a role in coordinating root growth, iron homeostasis and immunity pathways via regulation of callose synthases.
Mon Aug 01 00:00:00 UTC 2022
Characterization of enhancer fragments in Drosophila robo2.
Fly
Hauptman G,Reichert MC,Abdal Rhida MA,Evans TA
A-11122 was used in Immunocytochemistry-immunofluorescence to provide a general description of each fragment's expression in embryonic tissues outside of the nervous system, to serve as a resource for other researchers interested in robo2 expression and its functional roles outside the central nervous system.
Thu Dec 01 00:00:00 UTC 2022
Brain motor and fear circuits regulate leukocytes during acute stress.
Nature
Poller WC,Downey J,Mooslechner AA,Khan N,Li L,Chan CT,McAlpine CS,Xu C,Kahles F,He S,Janssen H,Mindur JE,Singh S,Kiss MG,Alonso-Herranz L,Iwamoto Y,Kohler RH,Wong LP,Chetal K,Russo SJ,Sadreyev RI,Weissleder R,Nahrendorf M,Frenette PS,Divangahi M,Swirski FK
A-11122 was used in Immunohistochemistry to show that distinct brain regions differentially and rapidly tailor the leukocyte landscape during psychological stress, thus calibrating the immune system's capacity to respond to physical threats.
Fri Jul 01 00:00:00 UTC 2022
Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation.
Frontiers in cellular neuroscience
Dannhäuser S,Mrestani A,Gundelach F,Pauli M,Komma F,Kollmannsberger P,Sauer M,Heckmann M,Paul MM
A-11122 was used in Immunohistochemistry to use MiMIC-based gene editing to endogenously tagged Drosophila Unc-13, allowing visualization of its expression.
Thu Nov 02 00:00:00 UTC 2023
CaMKII binds both substrates and activators at the active site.
Cell reports
Özden C,Sloutsky R,Mitsugi T,Santos N,Agnello E,Gaubitz C,Foster J,Lapinskas E,Esposito EA,Saneyoshi T,Kelch BA,Garman SC,Hayashi Y,Stratton MM
A-11122 was used in Western Blot to propose a mechanistic model where persistent CaMKII activity is facilitated by high-affinity binding partners that kinetically compete with autoinhibition by the regulatory segment to allow substrate phosphorylation.
Tue Jul 12 00:00:00 UTC 2022
Potential Variables for Improved Reproducibility of Neuronal Cell Grafts at Stroke Sites.
Cells
Krzyspiak J,Khodakhah K,Hébert JM
A-11122 was used in Immunohistochemistry-immunofluorescence to find that graft size at stroke sites correlates with the size of ischemic damage, host sex (females having graft sizes that correlate with damage), donor cell maturity, and host age, but not with the time of transplant after stroke.
Tue May 17 00:00:00 UTC 2022
The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision.
Nature communications
Chrystal PW,Lambacher NJ,Doucette LP,Bellingham J,Schiff ER,Noel NCL,Li C,Tsiropoulou S,Casey GA,Zhai Y,Nadolski NJ,Majumder MH,Tagoe J,D'Esposito F,Cordeiro MF,Downes S,Clayton-Smith J,Ellingford J,Mahroo OA,Hocking JC,Cheetham ME,Webster AR,Jansen G,Blacque OE,Allison WT,Au PYB,MacDonald IM,Arno G,Leroux MR
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest an uncharacterised pathomechanism for retinal dystrophy, and potentially for motile and non-motile ciliopathies in general.
Thu Nov 03 00:00:00 UTC 2022
Selectively Imaging Cranial Sensory Ganglion Neurons Using AAV-PHP.S.
eNeuro
Asencor AI,Dvoryanchikov G,Makhoul V,Tsoulfas P,Chaudhari N
A-11122 was used in Immunohistochemistry to suggest that the AAV-PHP.S serotype will be a powerful tool for anatomically and functionally mapping the receptive fields and circuits of the expanding numbers of molecular subtypes of many somatosensory and viscerosensory neurons that continue to be defined via single-cell RNA sequencing.
Wed Jun 08 00:00:00 UTC 2022
Enteroendocrine cell types that drive food reward and aversion.
eLife
Bai L,Sivakumar N,Yu S,Mesgarzadeh S,Ding T,Ly T,Corpuz TV,Grove JCR,Jarvie BC,Knight ZA
A-11122 was used in Immunohistochemistry to establish a cellular basis for how chemosensing in the gut drives learning about food.
Mon Aug 01 00:00:00 UTC 2022
The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies.
Nature communications
Courchaine E,Gelles-Watnick S,Machyna M,Straube K,Sauyet S,Enright J,Neugebauer KM
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to propose a model in which coilin NTD-NTD mediated assemblies make multivalent contacts with Nopp140 to achieve biomolecular condensation in the nucleus.
Wed Oct 12 00:00:00 UTC 2022
R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites.
Cell reports
Murphy JG,Gutzmann JJ,Lin L,Hu J,Petralia RS,Wang YX,Hoffman DA
A-11122 was used in Immunocytochemistry to identify a nano-scale interaction between Ca2+ channel subunit Cav2.3 and the pore-forming Kv4.2 subunit that regulates the amplitude of neuronal subthreshold voltage-gated transient K+ current to attenuate spontaneous synaptic input through a Kv4.2 surface localization mechanism.
Tue Jan 18 00:00:00 UTC 2022
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy.
Nature biomedical engineering
Sarkar D,Kang J,Wassie AT,Schroeder ME,Peng Z,Tarr TB,Tang AH,Niederst ED,Young JZ,Su H,Park D,Yin P,Tsai LH,Blanpied TA,Boyden ES
A-11122 was used in Immunocytochemistry-immunofluorescence to understand how proteins within these structures are arranged with nanoscale precision therefore requires that these structures be decrowded before labelling.
Thu Sep 01 00:00:00 UTC 2022
A population of descending neurons that regulates the flight motor of Drosophila.
Current biology : CB
Namiki S,Ros IG,Morrow C,Rowell WJ,Card GM,Korff W,Dickinson MH
A-11122 was used in Immunohistochemistry-immunofluorescence to identify a critical set of descending neurons that provides the sensitivity and dynamic range required for flight control.
Mon Mar 14 00:00:00 UTC 2022
Association of variants in the KIF1A gene with amyotrophic lateral sclerosis.
Translational neurodegeneration
Liao P,Yuan Y,Liu Z,Hou X,Li W,Wen J,Zhang K,Jiao B,Shen L,Jiang H,Guo J,Tang B,Zhang Z,Hu Z,Wang J
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to determine genetic associations in amyotrophic lateral sclerosis.
Wed Oct 26 00:00:00 UTC 2022
Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Annals of the New York Academy of Sciences
Fujiwara S,Nguyen TP,Furuse K,Fukazawa Y,Otani T,Furuse M
A-11122 was used in Immunoprecipitation to suggest that the interaction of claudins with ZO proteins is not a prerequisite for TJ formation at the most apical part of cell-cell contacts.
Sat Oct 01 00:00:00 UTC 2022
SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication.
Communications biology
Miyamoto Y,Itoh Y,Suzuki T,Tanaka T,Sakai Y,Koido M,Hata C,Wang CX,Otani M,Moriishi K,Tachibana T,Kamatani Y,Yoneda Y,Okamoto T,Oka M
A-11122 was used in Immunocytochemistry-immunoflourescence to conclude that SARS-CoV-2 ORF6 acts as a virulence factor via regulation of nucleocytoplasmic trafficking to accelerate viral replication, resulting in disease progression.
Thu May 19 00:00:00 UTC 2022
AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer.
Cellular and molecular life sciences : CMLS
Schneeweis C,Diersch S,Hassan Z,Krauß L,Schneider C,Lucarelli D,Falcomatà C,Steiger K,Öllinger R,Krämer OH,Arlt A,Grade M,Schmidt-Supprian M,Hessmann E,Wirth M,Rad R,Reichert M,Saur D,Schneider G
A-11122 was used in Western Blotting to establish FRA1 as a part of the molecular machinery controlling sensitivity to MAPK cascade inhibition allowing the development of mechanism-based therapies.
Mon Dec 19 00:00:00 UTC 2022
Oral and Injected Tamoxifen Alter Adult Hippocampal Neurogenesis in Female and Male Mice.
eNeuro
Smith BM,Saulsbery AI,Sarchet P,Devasthali N,Einstein D,Kirby ED
A-11122 was used in Immunohistochemistry-immunofluorescence to provide guidance for selection of TAM administration route and appropriate controls in adult neurogenesis studies using TAM-inducible Cre mice.
Fri Apr 22 00:00:00 UTC 2022
The Drosophila microRNA bantam regulates excitability in adult mushroom body output neurons to promote early night sleep.
iScience
Hobin M,Dorfman K,Adel M,Rivera-Rodriguez EJ,Kuklin EA,Ma D,Griffith LC
A-11122 was used in Immunohistochemistry-immunofluorescence to show that bantam acts in the adult to promote early nighttime sleep through a population of glutamatergic neurons that is intimately involved in applying contextual information to behaviors, the γ5β'2a/β'2mp/β'2mp_bilateral Mushroom Body Output Neurons (MBONs).
Fri Sep 16 00:00:00 UTC 2022
Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Neuron
Adaikkan C,Wang J,Abdelaal K,Middleton SJ,Bozzelli PL,Wickersham IR,McHugh TJ,Tsai LH
A-11122 was used in Immunohistochemistry to reveal a hitherto uncharacterized CH circuit in the visual cortex, establishing a causal link between this circuit and novelty discrimination behavior and highlighting its impairment in mouse models of neurodegeneration.
Wed Oct 05 00:00:00 UTC 2022
Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes.
mBio
Hocking SE,Stewart LB,Freville A,Reid AJ,Tarr SJ,Tetteh KKA,Flueck C,Ahouidi AD,Amambua-Ngwa A,Diakite M,Awandare GA,Conway DJ
A-11122 was used in Immunocytochemistry to show a unique and highly skewed pattern of natural expression frequencies of MSPDBL2, distinct from that of any other antigen.
Tue Aug 30 00:00:00 UTC 2022
Genetic analysis suggests a surface of PAT-4 (ILK) that interacts with UNC-112 (kindlin).
G3 (Bethesda, Md.)
Qadota H,McPherson A,Corbitt R,Dackowski EK,Matsunaga Y,Oberhauser AF,Benian GM
A-11122 was used in Immunohistochemistry-immunofluorescence to understand the molecular interaction between PAT-4 and UNC-112.
Wed Jul 06 00:00:00 UTC 2022
Traip controls mushroom body size by suppressing mitotic defects.
Development (Cambridge, England)
O'Neill RS,Rusan NM
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that proper brain size is ensured by the recently described role for TRAIP in unloading stalled replication forks in mitosis, which suppresses DNA bridges and premature neural stem cell loss to promote proper neuron number.
Fri Apr 01 00:00:00 UTC 2022
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking.
Nature neuroscience
Maza N,Wang D,Kowalski C,Stoveken HM,Dao M,Sial OK,Giles AC,Grill B,Martemyanov KA
A-11122 was used in Immunohistochemistry to propose that Ptchd1 plays an evolutionarily conserved role in protecting the µ-opioid receptor against overstimulation.
Thu Sep 01 00:00:00 UTC 2022
NUPR1 protects against hyperPARylation-dependent cell death.
Communications biology
Santofimia-Castaño P,Huang C,Liu X,Xia Y,Audebert S,Camoin L,Peng L,Lomberk G,Urrutia R,Soubeyran P,Neira JL,Iovanna J
A-11122 was used in Western Blotting to conclude that inactivation of NUPR1 induces a hyperPARylation, which in turn, induces a mitochondrial catastrophe and consequently a cell death through a non-canonical Parthanatos, since apoptosis inducing-factor (AIF) is not translocated out of the mitochondria.
Fri Jul 22 00:00:00 UTC 2022
Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle.
Cell reports
Tournaire G,Loopmans S,Stegen S,Rinaldi G,Eelen G,Torrekens S,Moermans K,Carmeliet P,Ghesquière B,Thienpont B,Fendt SM,van Gastel N,Carmeliet G
A-11122 was used in Immunohistochemistry to show that the metabolic plasticity of skeletal stem and progenitor cells allows them to bypass ETC blockade and preserve their self-renewal.
Tue Jul 26 00:00:00 UTC 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
A-11122 was used in Immunohistochemistry to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 UTC 2022
Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus.
Science advances
Scaramuzzino C,Cuoc EC,Pla P,Humbert S,Saudou F
A-11122 was used in Immunohistochemistry to observe similar retrograde waves of TrkA- and epidermal growth factor receptor (EGFR)-bearing endosomes.
Fri Jan 07 00:00:00 UTC 2022
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Nature structural & molecular biology
Happ JT,Arveseth CD,Bruystens J,Bertinetti D,Nelson IB,Olivieri C,Zhang J,Hedeen DS,Zhu JF,Capener JL,Bröckel JW,Vu L,King CC,Ruiz-Perez VL,Ge X,Veglia G,Herberg FW,Taylor SS,Myers BR
A-11122 was used in Immunoprecipitation to define a mode of GPCR-PKA communication that may be harnessed by a range of membrane receptors and kinases.
Sat Oct 01 00:00:00 UTC 2022
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.
Nature communications
Kay Y,Tsan L,Davis EA,Tian C,Décarie-Spain L,Sadybekov A,Pushkin AN,Katritch V,Kanoski SE,Herring BE
A-11122 was used in Western Blot to identify a cell-type-specific synaptic regulatory mechanism in the dentate gyrus that, when disrupted, impairs contextual information processing in rats.
Thu Feb 10 00:00:00 UTC 2022
Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.
The Journal of cell biology
Duncan ED,Han KJ,Trout MA,Prekeris R
A-11122 was used in Immunocytochemistry-immunofluorescence to exhibit that Rab40b/Cullin5 ubiquitylates and regulates Rap2-dependent actin dynamics at the leading edge, a process that is required for breast cancer cell migration and invasion.
Mon Apr 04 00:00:00 UTC 2022
Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Punzo C,Ash JD,Lobanova ES
A-11122 was used in Western Blotting to suggest that chronic activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway in degenerating photoreceptor neurons could stimulate the degradation of ubiquitinated proteins and enhance proteasomal activity through phosphorylation.
Tue Mar 15 00:00:00 UTC 2022
Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1.
Molecular biology of the cell
Powers RM,Daza R,Koehler AE,Courchet J,Calabrese B,Hevner RF,Halpain S
A-11122 was used in Immunocytochemistry-immunofluorescence to demonstrate that Nav1 works at the interface of microtubules, actin, and plasma membrane to organize the cell periphery and promote uptake of growth and guidance cues to facilitate neural morphogenesis during development.
Wed Jun 01 00:00:00 UTC 2022
Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chouhan NS,Sehgal A
A-11122 was used in Immunohistochemistry-immunofluorescence to find that sweet-sensing neurons drive the recruitment of specific reward signaling dopaminergic neurons to establish sleep-dependent memory.
Wed May 04 00:00:00 UTC 2022
Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.
Nature communications
Pinto PB,Domsch K,Gao X,Wölk M,Carnesecchi J,Lohmann I
A-11122 was used in Immunohistochemistry to show that Hox-regulated morphogenesis seems to result from the co-evolution of Hox binding affinity and Hox dosage for precise target gene regulation.
Fri Aug 26 00:00:00 UTC 2022
Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.
Frontiers in cellular neuroscience
Liu JW,Li H,Zhang Y
A-11122 was used in Western Blotting to demonstrate that Npas3 knockdown profoundly impaired neuronal radial migration and changed the laminar cell fate of the cells detained in the deep cortical layers.
Wed Nov 02 00:00:00 UTC 2022
Npas3 regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex.
Frontiers in cellular neuroscience
Liu JW,Li H,Zhang Y
A-11122 was used in Western Blotting to demonstrate that Npas3 knockdown profoundly impaired neuronal radial migration and changed the laminar cell fate of the cells detained in the deep cortical layers.
Wed Nov 02 00:00:00 UTC 2022
Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei.
Nature microbiology
López-Escobar L,Hänisch B,Halliday C,Ishii M,Akiyoshi B,Dean S,Sunter JD,Wheeler RJ,Gull K
A-11122 was used in Chromatin immunoprecipitation to show that ESB1 is necessary for recruitment of a subset of ESB components, including RNA polymerase I, revealing that the ESB has separately assembled subdomains.
Mon Aug 01 00:00:00 UTC 2022
Single-cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos.
Molecular systems biology
Velten J,Gao X,Van Nierop Y Sanchez P,Domsch K,Agarwal R,Bognar L,Paulsen M,Velten L,Lohmann I
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that homeodomain transcription factor and immunoglobulin molecule expression could be directly linked and function as a crucial determinant of neuronal circuit structure.©2022 The Authors.
Tue Mar 01 00:00:00 UTC 2022
The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism.
G3 (Bethesda, Md.)
Corgiat EB,List SM,Rounds JC,Yu D,Chen P,Corbett AH,Moberg KH
A-11122 was used in Immunohistochemistry-immunofluorescence to present an analysis of a brain proteomic dataset that indicates that multiple planar cell polarity proteins are affected by Nab2 loss.
Mon May 30 00:00:00 UTC 2022
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
Nature
Xu Y,Viswanatha R,Sitsel O,Roderer D,Zhao H,Ashwood C,Voelcker C,Tian S,Raunser S,Perrimon N,Dong M
A-11122 was used in Immunocytochemistry-immunofluorescence to use genome-wide CRISPR-Cas9-mediated knockout screening in Drosophila melanogaster S2R+ cells and identify Visgun (Vsg) as a receptor for an archetypal P.
Sat Oct 01 00:00:00 UTC 2022
Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice.
Frontiers in neuroscience
Macpherson T,Kim JY,Hikida T
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate effects of the nucleus accumbens in mouse brains.
Sat Jul 16 00:00:00 UTC 2022
Cell-Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis.
Cells
Gomes de Almeida P,Rifes P,Martins-Jesus AP,Pinheiro GG,Andrade RP,Thorsteinsdóttir S
A-11122 was used in Immunohistochemistry to suggest that the fibronectin-integrin-ROCK-NM II axis regulates segmentation clock dynamics and dictates the spatio-temporal localization of somitic clefts.
Wed Jun 22 00:00:00 UTC 2022
Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7.
Frontiers in molecular biosciences
Colcombet-Cazenave B,Cordier F,Zhu Y,Bouvier G,Litsardaki E,Laserre L,Prevost MS,Raynal B,Caillet-Saguy C,Wolff N
A-11122 was used in Pull-Down Assay to show that the stability and binding properties of the PDZ tandem are affected by two deafness-causing mutations located in the binding grooves of PDZD7 PDZ domains.
Sat Jul 16 00:00:00 UTC 2022
c-Abl-induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells.
Glia
Zhang J,Sun JG,Xing X,Wu R,Zhou L,Zhang Y,Yuan F,Wang S,Yuan Z
A-11122 was used in Western Blotting to identify the important role of c-Abl in OLs during developmental myelination and remyelination in a disease model.
Wed Jun 01 00:00:00 UTC 2022
A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System.
International journal of molecular sciences
Bandla A,Melancon E,Taylor CR,Davidson AE,Eisen JS,Ganz J
A-11122 was used in Immunohistochemistry-immunofluorescence to find that EPCs and the majority of ENS neurons express ret:GFP during ENS development.
Sat Dec 10 00:00:00 UTC 2022
Protocol for analysis of senescent neuronal stem cells in genetic-modified embryonic mice using in utero electroporation technique.
STAR protocols
Chen L,Li Y,Wu Y,Li S,Chang X,Wu H
A-11122 was used in Immunocytochemistry-immunoflourescence to present a detailed protocol for identification and analysis of senescent neuronal stem cells (NSCs) in the developing mouse embryonic neocortex using in utero electroporation.
Fri Sep 16 00:00:00 UTC 2022
GABA facilitates spike propagation through branch points of sensory axons in the spinal cord.
Nature neuroscience
Hari K,Lucas-Osma AM,Metz K,Lin S,Pardell N,Roszko DA,Black S,Minarik A,Singla R,Stephens MJ,Pearce RA,Fouad K,Jones KE,Gorassini MA,Fenrich KK,Li Y,Bennett DJ
A-11122 was used in Immunohistochemistry-immunofluorescence to report that activating GAD2+ neurons directly with optogenetics or indirectly by cutaneous stimulation actually facilitates sensory feedback to motor neurons in rodents and humans.
Sat Oct 01 00:00:00 UTC 2022
Brain-wide electrical dynamics encode individual appetitive social behavior.
Neuron
Mague SD,Talbot A,Blount C,Walder-Christensen KK,Duffney LJ,Adamson E,Bey AL,Ndubuizu N,Thomas GE,Hughes DN,Grossman Y,Hultman R,Sinha S,Fink AM,Gallagher NM,Fisher RL,Jiang YH,Carlson DE,Dzirasa K
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal the architecture whereby the brain integrates distributed activity across timescales to encode an appetitive brain state underlying individual differences in social behavior.
Wed May 18 00:00:00 UTC 2022
Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6.
Frontiers in genetics
Lennon J,Zur Lage P,von Kriegsheim A,Jarman AP
A-11122 was used in Immunohistochemistry to determine protein involvement in Drosophila axonemal dynein motors.
Sun Sep 01 00:00:00 UTC 2024
Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier.
eLife
Tran NL,Ferreira LM,Alvarez-Moya B,Buttiglione V,Ferrini B,Zordan P,Monestiroli A,Fagioli C,Bezzecchi E,Scotti GM,Esposito A,Leone R,Gnasso C,Brendolan A,Guidotti LG,Sitia G
A-11122 was used in Immunohistochemistry-immunofluorescence to use mouse models of hepatic metastatization to demonstrate that the continuous infusion of therapeutic doses of interferon-alpha (IFNα) controls CRC invasion by acting on hepatic endothelial cells (HECs).
Tue Oct 25 00:00:00 UTC 2022
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.
Diabetes
Chu CMJ,Modi H,Ellis C,Krentz NAJ,Skovsø S,Zhao YB,Cen H,Noursadeghi N,Panzhinskiy E,Hu X,Dionne DA,Xia YH,Xuan S,Huising MO,Kieffer TJ,Lynn FC,Johnson JD
A-11122 was used in Immunocytochemistry-immunofluorescence to demonstrate that the heterogeneity of insulin production, observed in mouse and human β-cells, can be accounted for by dynamic states of insulin gene activity.
Thu Dec 01 00:00:00 UTC 2022
CMTr cap-adjacent 2'-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses.
Nature communications
Haussmann IU,Wu Y,Nallasivan MP,Archer N,Bodi Z,Hebenstreit D,Waddell S,Fray R,Soller M
A-11122 was used in Immunohistochemistry to show that the two cap methyltransferases of Drosophila can methylate the ribose of the first nucleotide in mRNA.
Tue Mar 08 00:00:00 UTC 2022
Differentiation of Human Adipose-Derived Mesenchymal Stromal/Stem Cells into Insulin-Producing Cells with A Single Tet-Off Lentiviral Vector System.
Cell journal
Moriyama H,Moriyama M,Ozawa T,Tsuruta D,Hayakawa T
A-11122 was used in Western Blotting to investigate whether MafA and NeuroD1 would cooperate with Pdx-1 in the differentiation of hASC into insulin-producing cells.
Thu Dec 01 00:00:00 UTC 2022
CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines.
IBRO neuroscience reports
Zernov N,Bezprozvanny I,Popugaeva E
A-11122 was used in Western Blot to show that the effect of CaMKIIβ knockdown on the nSOCE may be associated with a decrease of dendritic spine head size.
Wed Jun 01 00:00:00 UTC 2022
The consequences of differential origin licensing dynamics in distinct chromatin environments.
Nucleic acids research
Mei L,Kedziora KM,Song EA,Purvis JE,Cook JG
A-11122 was used in Immunocytochemistry-immunofluorescence to show that G1 length is critical for sufficient MCM loading, particularly in heterochromatin, to ensure complete genome duplication and to maintain genome stability.
Fri Sep 23 00:00:00 UTC 2022
Complex representation of taste quality by second-order gustatory neurons in Drosophila.
Current biology : CB
Snell NJ,Fisher JD,Hartmann GG,Zolyomi B,Talay M,Barnea G
A-11122 was used in Immunohistochemistry to demonstrate an unexpected complexity in the representation of sweet and bitter tastants by second-order neurons of the gustatory circuit.
Mon Sep 12 00:00:00 UTC 2022
A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis.
Science advances
Gerstmann K,Kindbeiter K,Telley L,Bozon M,Reynaud F,Théoulle E,Charoy C,Jabaudon D,Moret F,Castellani V
A-11122 was used in Immunohistochemistry-immunofluorescence to discover that two different complexes, Sema3B/Nrp2 and Sema3F/Nrp1, exert dual effects on apical endfeet dynamics, nuclei positioning, and RGC progeny.
Wed Nov 16 00:00:00 UTC 2022
Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3.
NPJ breast cancer
Le TT,Payne SL,Buckwald MN,Hayes LA,Parker SR,Burge CB,Oudin MJ
A-11122 was used in Immunohistochemistry to identify a mechanism by which nerves contribute to breast cancer migration and metastasis by inducing a shift in TNBC cell gene expression and support the rationale for disrupting neuron-cancer cell interactions to target metastasis.
Fri Nov 04 00:00:00 UTC 2022
Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model.
Journal of extracellular vesicles
Linnemannstöns K,Karuna M P,Witte L,Choezom D,Honemann-Capito M,Lagurin AS,Schmidt CV,Shrikhande S,Steinmetz LK,Wiebke M,Lenz C,Gross JC
A-11122 was used in Western Blotting to present an in vivo model to study EV secretion using the fat body and the haemolymph of the fruit fly, Drosophila melanogaster.
Thu Sep 01 00:00:00 UTC 2022
Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy.
Molecular therapy. Methods & clinical development
Sommer N,Roumane A,Han W,Delibegović M,Rochford JJ,Mcilroy GD
A-11122 was used in Immunohistochemistry to propose that gene therapy offers great potential as a therapeutic strategy to correct multiple metabolic complications in patients with congenital lipodystrophy.
Thu Dec 08 00:00:00 UTC 2022
Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.
iScience
Marty FH,Bettamin L,Thouard A,Bourgade K,Allart S,Larrieu G,Malnou CE,Gonzalez-Dunia D,Suberbielle E
A-11122 was used in Western Blot to decipher the interplay between Borna disease virus-1 infection and double-strand breaks, and to unravel its consequences on viral replication and neuronal function.
Fri Jan 21 00:00:00 UTC 2022
Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis.
PLoS genetics
Na HJ,Abramowitz LK,Hanover JA
A-11122 was used in Immunohistochemistry to reveal a complex coordinated regulation between O-GlcNAcylation and the cytosolic glycanase PNG1 critical to balancing proliferation and apoptosis to maintain gut homeostasis.
Tue Mar 01 00:00:00 UTC 2022
Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice.
Nature communications
Takahashi A,Durand-de Cuttoli R,Flanigan ME,Hasegawa E,Tsunematsu T,Aleyasin H,Cherasse Y,Miya K,Okada T,Keino-Masu K,Mitsui K,Li L,Patel V,Blitzer RD,Lazarus M,Tanaka KF,Yamanaka A,Sakurai T,Ogawa S,Russo SJ
A-11122 was used in Immunohistochemistry to demonstrate that the LHb glutamatergic inputs to the DRN promote aggressive arousal induced by social instigation, which contributes to aggressive behavior by activating VTA-projecting non-serotonergic DRN neurons as one of its potential targets.
Thu Jul 21 00:00:00 UTC 2022
Role of Nrp1 in controlling cortical inter-hemispheric circuits.
eLife
Martín-Fernández F,Bermejo-Santos A,Bragg-Gonzalo L,Briz CG,Serrano-Saiz E,Nieto M
A-11122 was used in Immunohistochemistry to conclude that an exquisite temporal and spatial regulation of Nrp1 expression determines SS interhemispheric maps.
Tue Mar 01 00:00:00 UTC 2022
Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis.
Nature communications
Zhao T,Lu J,Zhang H,Xue M,Pan J,Ma L,Berger F,Jiang D
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, ChIP Assay to suggest a fundamental role of H3.3 in initiating chromatin accessibility at regulatory regions in seed and licensing the embryonic to post-embryonic transition.
Tue Dec 13 00:00:00 UTC 2022
Neuromuscular embodiment of feedback control elements in Drosophila flight.
Science advances
Whitehead SC,Leone S,Lindsay T,Meiselman MR,Cowan NJ,Dickinson MH,Yapici N,Stern DL,Shirangi T,Cohen I
A-11122 was used in Immunohistochemistry to provide evidence for an organizational principle in which each muscle contributes to a specific functional role in flight control, a finding that highlights the power of using top-down behavioral modeling to guide bottom-up cellular manipulation studies.
Wed Dec 14 00:00:00 UTC 2022
KARRIKIN INSENSITIVE2 regulates leaf development, root system architecture and arbuscular-mycorrhizal symbiosis in Brachypodium distachyon.
The Plant journal : for cell and molecular biology
Meng Y,Varshney K,Incze N,Badics E,Kamran M,Davies SF,Oppermann LMF,Magne K,Dalmais M,Bendahmane A,Sibout R,Vogel J,Laudencia-Chingcuanco D,Bond CS,Soós V,Gutjahr C,Waters MT
A-11122 was used in Western Blot to study the core functions of Karrikin insensitive2 (KAI2) in plant development by characterising the developmental functions of KAI2 in the grass Brachypodium distachyon using molecular, physiological and biochemical approaches.
Tue Mar 01 00:00:00 UTC 2022
Glutamate in primary afferents is required for itch transmission.
Neuron
Cui L,Guo J,Cranfill SL,Gautam M,Bhattarai J,Olson W,Beattie K,Challis RC,Wu Q,Song X,Raabe T,Gradinaru V,Ma M,Liu Q,Luo W
A-11122 was used in Immunohistochemistry to establish a new model in which glutamate is an essential neurotransmitter in primary afferents for itch transmission, whereas neuropeptide neuromedin B (Nmb) signaling enhances its activities.
Wed Mar 02 00:00:00 UTC 2022
Endophilin-B regulates autophagy during synapse development and neurodegeneration.
Neurobiology of disease
Hernandez-Diaz S,Ghimire S,Sanchez-Mirasierra I,Montecinos-Oliva C,Swerts J,Kuenen S,Verstreken P,Soukup SF
A-11122 was used in Immunohistochemistry to show that EndoB is required to prevent neuronal loss.
Tue Feb 01 00:00:00 UTC 2022
Anterior thalamic circuits crucial for working memory.
Proceedings of the National Academy of Sciences of the United States of America
Roy DS,Zhang Y,Aida T,Shen C,Skaggs KM,Hou Y,Fleishman M,Mosto O,Weninger A,Feng G
A-11122 was used in Immunohistochemistry to find essential role of anteroventral (AV) thalamus excitation in maintaing spatial working memory, with fewer unintended effects compared to direct PFC manipulations while resurrecting perfomrance in ageing.
Tue May 17 00:00:00 UTC 2022
Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence.
Nature communications
Tu X,Ren S,Shen W,Li J,Li Y,Li C,Li Y,Zong Z,Xie W,Grierson D,Fei Z,Giovannoni J,Li P,Zhong S
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, ChIP Assay to show that genome cis-variation caused wide-spread TF binding divergence, and most of the TF binding sites are genetically redundant.
Fri Dec 09 00:00:00 UTC 2022
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone.
Fluids and barriers of the CNS
Norton ES,Whaley LA,Ulloa-Navas MJ,García-Tárraga P,Meneses KM,Lara-Velazquez M,Zarco N,Carrano A,Quiñones-Hinojosa A,García-Verdugo JM,Guerrero-Cázares H
A-11122 was used in Immunohistochemistry to investigate the ependymal cell barrier and its derived extracellular matrix (ECM) fractones in the vicinity of a Glioblastoma tumor.
Mon Jul 11 00:00:00 UTC 2022
Expression of expanded GGC repeats within NOTCH2NLC causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease.
Science advances
Liu Q,Zhang K,Kang Y,Li Y,Deng P,Li Y,Tian Y,Sun Q,Tang Y,Xu K,Zhou Y,Wang JL,Guo J,Li JD,Xia K,Meng Q,Allen EG,Wen Z,Li Z,Jiang H,Shen L,Duan R,Yao B,Tang B,Jin P,Pan Y
A-11122 was used in Immunocytochemistry-immunofluorescence to suggest that dysfunction of hnRNPM could play an important role in the molecular pathogenesis of NIID.
Fri Nov 25 00:00:00 UTC 2022
An RNA granule for translation quality control in Saccharomyces cerevisiae.
Journal of cell science
Dhaliwal JS,Panozzo C,Benard L,Zerges W
A-11122 was used in Immunocytochemistry-immunofluorescence to show that oxidized RNA bodies are RNA granules in Saccharomyces cerevisiae.
Thu Dec 01 00:00:00 UTC 2022
Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4.
Brain : a journal of neurology
Kannan A,Cuartas J,Gangwani P,Branzei D,Gangwani L
A-11122 was used in Simple Western - Size to propose that ZPR1 collaborates with SETX and may function as a molecular brake to regulate SETX-dependent R-loop resolution activity critical for the normal functioning of motor neurons.
Wed Sep 14 00:00:00 UTC 2022
The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response.
Nature communications
Zhang C,Kim AJ,Rivera-Perez C,Noriega FG,Kim YJ
A-11122 was used in Immunohistochemistry to identify the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis (yolk accumulation) that occurs post-eclosion and its re-initiation post-mating.
Fri Feb 18 00:00:00 UTC 2022
Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation.
Development, growth & differentiation
Ikeda T,Inamori K,Kawanishi T,Takeda H
A-11122 was used in Immunohistochemistry to indicate that differentiated KV-epithelial cells possess unique plasticity in that they are reemployed into mesodermal lineages through transdifferentiation after they complete their initial role in KV.
Fri Apr 01 00:00:00 UTC 2022
CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.
Nature communications
Zeng W,Yue L,Lam KSW,Zhang W,So WK,Tse EHY,Cheung TH
A-11122 was used in Immunoprecipitation to characterize CPEB1 as a key regulator to reprogram the translational landscape directing SC activation and subsequent proliferation.
Thu Feb 17 00:00:00 UTC 2022
Microglial control of neuronal development via somatic purinergic junctions.
Cell reports
Cserép C,Schwarcz AD,Pósfai B,László ZI,Kellermayer A,Környei Z,Kisfali M,Nyerges M,Lele Z,Katona I
A-11122 was used in Immunohistochemistry-immunofluorescence to propose that early developmental formation of somatic purinergic junctions represents an important interface for microglia to monitor the status of immature neurons and control neurodevelopment.
Tue Sep 20 00:00:00 UTC 2022
Local translation provides the asymmetric distribution of CaMKII required for associative memory formation.
Current biology : CB
Chen N,Zhang Y,Adel M,Kuklin EA,Reed ML,Mardovin JD,Bakthavachalu B,VijayRaghavan K,Ramaswami M,Griffith LC
A-11122 was used in Immunohistochemistry to identify elevated levels of translation of an evenly distributed mRNA as a novel strategy for generating subcellular biochemical asymmetries.
Mon Jun 20 00:00:00 UTC 2022
Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase.
Cell reports
Bu S,Tang Q,Wang Y,Lau SSY,Yong WL,Yu F
A-11122 was used in Immunocytochemistry to demonstrate that Drosophila CLASP governs dendritic microtubule orientation and dendrite pruning at least partly via suppressing Par-1 kinase.
Tue May 31 00:00:00 UTC 2022
Neural network organization for courtship-song feature detection in Drosophila.
Current biology : CB
Baker CA,McKellar C,Pang R,Nern A,Dorkenwald S,Pacheco DA,Eckstein N,Funke J,Dickson BJ,Murthy M
A-11122 was used in Immunohistochemistry-immunofluorescence to study auditory activity in the Drosophila melanogaster brain and investigate feature selectivity for the two main modes of fly courtship song, sinusoids and pulse trains.
Mon Aug 08 00:00:00 UTC 2022
Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.
The Plant cell
Wang P,Clark NM,Nolan TM,Song G,Bartz PM,Liao CY,Montes-Serey C,Katz E,Polko JK,Kieber JJ,Kliebenstein DJ,Bassham DC,Walley JW,Yin Y,Guo H
A-11122 was used in Western Blot to reveal novel functions for FER and provides new insights into the underlying mechanisms of FER function.
Mon Jul 04 00:00:00 UTC 2022
WDR5-HOTTIP Histone Modifying Complex Regulates Neural Migration and Dendrite Polarity of Pyramidal Neurons via Reelin Signaling.
Molecular neurobiology
Ka M,Kim HG,Kim WY
A-11122 was used in Immunohistochemistry to demonstrate a novel role for WDR5 in neuronal development and provide mechanistic insights into the neuropathology associated with histone methyltransferase dysfunction.
Mon Aug 01 00:00:00 UTC 2022
A Scribble/Cdep/Rac pathway controls follower-cell crawling and cluster cohesion during collective border-cell migration.
Developmental cell
Campanale JP,Mondo JA,Montell DJ
A-11122 was used in Immunohistochemistry to identify a Rac guanine nucleotide exchange factor, Cdep, which also regulates follower-cell movement and cluster cohesion.
Mon Nov 07 00:00:00 UTC 2022
Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem.
Cell
Li F,Jiang H,Shen X,Yang W,Guo C,Wang Z,Xiao M,Cui L,Luo W,Kim BS,Chen Z,Huang AJW,Liu Q
A-11122 was used in Immunohistochemistry to hypothesize that a neuronal population postsynaptic to nasal sensory neurons mediates sneezing in this region.
Thu Jul 08 00:00:00 UTC 2021
DMA-tudor interaction modules control the specificity of in vivo condensates.
Cell
Courchaine EM,Barentine AES,Straube K,Lee DR,Bewersdorf J,Neugebauer KM
A-11122 was used in Western Blotting to conclude that DMA-tudor interaction modules-combinations of tudor domains bound to their DMA ligand(s)-represent versatile yet specific regulators of MLO assembly, composition, and morphology.
Thu Jul 08 00:00:00 UTC 2021
A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila.
Cell
Chiu H,Hoopfer ED,Coughlan ML,Pavlou HJ,Goodwin SF,Anderson DJ
A-11122 was used in Immunohistochemistry to reveal a circuit logic for the neural control of behaviors that include both sexually monomorphic and dimorphic actions, which may generalize to other organisms.
Thu Jan 21 00:00:00 UTC 2021
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Science (New York, N.Y.)
Gwon Y,Maxwell BA,Kolaitis RM,Zhang P,Kim HJ,Taylor JP
A-11122 was used in Western Blotting to investigate if targeting of G3BP1 weakened the stress granule-specific interaction network, resulting in granule disassembly.
Fri Jun 25 00:00:00 UTC 2021
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Cell host & microbe
Walch P,Selkrig J,Knodler LA,Rettel M,Stein F,Fernandez K,Viéitez C,Potel CM,Scholzen K,Geyer M,Rottner K,Steele-Mortimer O,Savitski MM,Holden DW,Typas A
A-11122 was used in Western Blotting to provide a method for probing host-pathogen PPIs during infection and a resource for interrogating STm effector mechanisms.
Wed Aug 11 00:00:00 UTC 2021
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS.
Nature neuroscience
Lee H,Lee JJ,Park NY,Dubey SK,Kim T,Ruan K,Lim SB,Park SH,Ha S,Kovlyagina I,Kim KT,Kim S,Oh Y,Kim H,Kang SU,Song MR,Lloyd TE,Maragakis NJ,Hong YB,Eoh H,Lee G
A-11122 was used in Immunohistochemistry to pinpoint a catalytic step of lipid metabolism as a potential therapeutic target for ALS.
Wed Dec 01 00:00:00 UTC 2021
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex.
Nature neuroscience
Valero M,Viney TJ,Machold R,Mederos S,Zutshi I,Schuman B,Senzai Y,Rudy B,Buzsáki G
A-11122 was used in Immunohistochemistry to identify these down state-active (DSA) neurons as deep-layer neocortical neurogliaform cells that express ID2 and Nkx2.1 and are weakly immunoreactive to neuronal nitric oxide synthase. DSA neurons are weakly excited by deep-layer pyramidal cells and strongly inhibited by several other GABAergic cell types.
Mon Mar 01 00:00:00 UTC 2021
Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice.
Cell stem cell
Nakamura Y,Jörg DJ,Kon Y,Simons BD,Yoshida S
A-11122 was used in Immunocytochemistry to show that, after a large population of donor spermatogonia settle in host testes, through stochastic fate choice, only a small fraction persist and regenerate over the long term, and the rest are lost through differentiation and cell death.
Thu Aug 05 00:00:00 UTC 2021
A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.
The Journal of clinical investigation
Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR
A-11122 was used in Immunohistochemistry to harness gene-modified T cells as a vaccine platform and developed cancer vaccines composed of autologous T cells modified with tumor antigens and additional adjuvant signals (Tvax).
Mon Aug 16 00:00:00 UTC 2021
A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization.
Molecular cell
Forey R,Barthe A,Tittel-Elmer M,Wery M,Barrault MB,Ducrot C,Seeber A,Krietenstein N,Szachnowski U,Skrzypczak M,Ginalski K,Rowicka M,Cobb JA,Rando OJ,Soutourina J,Werner M,Dubrana K,Gasser SM,Morillon A,Pasero P,Lengronne A,Poli J
A-11122 was used in ChIP assay to demonstrate a novel role for MRX in budding yeast transcription and chromosome organization.
Thu Jan 07 00:00:00 UTC 2021
ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
Nucleic acids research
Wang Y,Zhai B,Tan T,Yang X,Zhang J,Song M,Tan Y,Yang X,Chu T,Zhang S,Wang S,Zhang L
A-11122 was used in Immunocytochemistry to show Esa1, the NuA4 complex catalytic subunit, is constitutively expressed and localizes on chromatin loops during meiosis.
Mon Sep 20 00:00:00 UTC 2021
Highly selective brain-to-gut communication via genetically defined vagus neurons.
Neuron
Tao J,Campbell JN,Tsai LT,Wu C,Liberles SD,Lowell BB
A-11122 was used in Immunohistochemistry to conclude that the vagus motor nerve communicates via genetically defined labeled lines to control functionally unique enteric neurons within discrete subregions of the gastrointestinal tract.
Wed Jul 07 00:00:00 UTC 2021
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Neuron
Han S,Okawa S,Wilkinson GA,Ghazale H,Adnani L,Dixit R,Tavares L,Faisal I,Brooks MJ,Cortay V,Zinyk D,Sivitilli A,Li S,Malik F,Ilnytskyy Y,Angarica VE,Gao J,Chinchalongporn V,Oproescu AM,Vasan L,Touahri Y,David LA,Raharjo E,Kim JW,Wu W,Rahmani W,Chan JA,Kovalchuk I,Attisano L,Kurrasch D,Dehay C,Swaroop A,Castro DS,Biernaskie J,Del Sol A,Schuurmans C
A-11122 was used in Immunohistochemistry to show that Neurog2 and Ascl1 proneural genes regulate cortical progenitor cell differentiation through crossrepressive interactions to sustain neurogenic continuity in a lissencephalic rodent brain.
Wed Sep 15 00:00:00 UTC 2021
Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes.
Developmental cell
Peloggia J,Münch D,Meneses-Giles P,Romero-Carvajal A,Lush ME,Lawson ND,McClain M,Pan YA,Piotrowski T
A-11122 was used in Immunohistochemistry to study cell invasion and migration, as well as the physiological adaptation of vertebrate organs to changing environmental conditions.
Mon May 03 00:00:00 UTC 2021
Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
Developmental cell
Lavalou J,Mao Q,Harmansa S,Kerridge S,Lellouch AC,Philippe JM,Audebert S,Camoin L,Lecuit T
A-11122 was used in Immunohistochemistry to reveal that Toll-8 and Cirl exhibit mutually dependent planar polarity in response to quantitative differences in Toll-8 expression between neighboring cells in Drosophila.
Mon Jun 07 00:00:00 UTC 2021
Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
Autophagy
Thirumalaikumar VP,Gorka M,Schulz K,Masclaux-Daubresse C,Sampathkumar A,Skirycz A,Vierstra RD,Balazadeh S
A-11122 was used in Western Blotting to demonstrate that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS.
Wed Sep 01 00:00:00 UTC 2021
Metformin rescues muscle function in BAG3 myofibrillar myopathy models.
Autophagy
Ruparelia AA,McKaige EA,Williams C,Schulze KE,Fuchs M,Oorschot V,Lacene E,Meregalli M,Lee C,Serrano RJ,Baxter EC,Monro K,Torrente Y,Ramm G,Stojkovic T,Lavoie JN,Bryson-Richardson RJ
A-11122 was used in Immunocytochemistry to show BAG3P209L expression is sufficient to promote protein aggregation, it is the loss of BAG3 due to its sequestration within aggregates, which results in impaired autophagic activity, and subsequent muscle weakness.
Wed Sep 01 00:00:00 UTC 2021
PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice.
Proceedings of the National Academy of Sciences of the United States of America
Li J,Liu S,Song C,Hu Q,Zhao Z,Deng T,Wang Y,Zhu T,Zou L,Wang S,Chen J,Liu L,Hou H,Yuan K,Zheng H,Liu Z,Chen X,Sun W,Xiao B,Xiong W
A-11122 was used in Immunohistochemistry to demonstrate that OHCs serve as effector cells, combining with PIEZO2 as an essential molecule for ultrasonic hearing in mice.
Tue Jul 13 00:00:00 UTC 2021
Hugin+ neurons provide a link between sleep homeostat and circadian clock neurons.
Proceedings of the National Academy of Sciences of the United States of America
Schwarz JE,King AN,Hsu CT,Barber AF,Sehgal A
A-11122 was used in Immunohistochemistry to propose that hugin + neurons integrate circadian and sleep signals to modulate circadian circuitry and regulate the timing of sleep.
Tue Nov 23 00:00:00 UTC 2021
A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein To Facilitate the Detection of SARS-CoV-2.
Journal of clinical microbiology
Ponce-Rojas JC,Costello MS,Proctor DA,Kosik KS,Wilson MZ,Arias C,Acosta-Alvear D
A-11122 was used in Western Blotting to proposed Precipitation Enhanced Analyte RetrievaL as an alternative solution for SARS-CoV-2 testing that address RNA extraction kits bottlenecking.
Fri Mar 19 00:00:00 UTC 2021
Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
Current biology : CB
Hachimi M,Grabowski C,Campanario S,Herranz G,Baonza G,Serrador JM,Gomez-Lopez S,Barea MD,Bosch-Fortea M,Gilmour D,Bagnat M,Rodriguez-Fraticelli AE,Martin-Belmonte F
A-11122 was used in Immunocytochemistry to demonstrate the role of Smoothelin-like 2 in apical cortex maturation during epithelial morphogenesis.
Mon Feb 22 00:00:00 UTC 2021
Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
Current biology : CB
Hachimi M,Grabowski C,Campanario S,Herranz G,Baonza G,Serrador JM,Gomez-Lopez S,Barea MD,Bosch-Fortea M,Gilmour D,Bagnat M,Rodriguez-Fraticelli AE,Martin-Belmonte F
A-11122 was used in Immunocytochemistry to demonstrate the role of Smoothelin-like 2 in apical cortex maturation during epithelial morphogenesis.
Mon Feb 22 00:00:00 UTC 2021
Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.
Current biology : CB
Hachimi M,Grabowski C,Campanario S,Herranz G,Baonza G,Serrador JM,Gomez-Lopez S,Barea MD,Bosch-Fortea M,Gilmour D,Bagnat M,Rodriguez-Fraticelli AE,Martin-Belmonte F
A-11122 was used in Immunocytochemistry to demonstrate the role of Smoothelin-like 2 in apical cortex maturation during epithelial morphogenesis.
Mon Feb 22 00:00:00 UTC 2021
Astroglial Calcium Signaling Encodes Sleep Need in Drosophila.
Current biology : CB
Blum ID,Keleş MF,Baz ES,Han E,Park K,Luu S,Issa H,Brown M,Ho MCW,Tabuchi M,Liu S,Wu MN
A-11122 was used in Immunocytochemistry to define astroglial Ca2+ signaling mechanisms encoding sleep need and reveal dynamic properties of the sleep homeostatic control system.
Mon Jan 11 00:00:00 UTC 2021
Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
PLoS biology
Arveseth CD,Happ JT,Hedeen DS,Zhu JF,Capener JL,Klatt Shaw D,Deshpande I,Liang J,Xu J,Stubben SL,Nelson IB,Walker MF,Kawakami K,Inoue A,Krogan NJ,Grunwald DJ,Hüttenhain R,Manglik A,Myers BR
A-11122 was used in Western Blot to demonstrate a mechanism directly linking Hh signal transduction at the membrane to GLI transcription in the nucleus.
Thu Apr 01 00:00:00 UTC 2021
Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors.
Cellular and molecular life sciences : CMLS
Hernaiz-Llorens M,Roselló-Busquets C,Durisic N,Filip A,Ulloa F,Martínez-Mármol R,Soriano E
A-11122 was used in Western Blot to indicate that the distribution of all UNC5 receptors into cholesterol-enriched raft microdomains is heterogeneous and that the specific localization has functional consequences for the axonal chemorepulsion against Netrin-1.
Mon Mar 01 00:00:00 UTC 2021
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.
Cellular and molecular life sciences : CMLS
Castroflorio E,den Hoed J,Svistunova D,Finelli MJ,Cebrian-Serrano A,Corrochano S,Bassett AR,Davies B,Oliver PL
A-11122 was used in Immunocytochemistry to investigate the molecular function of nuclear receptor coactivator 7 in neurons and generated a novel mouse model to determine the consequences of deleting this locus in vivo.
Thu Apr 01 00:00:00 UTC 2021
A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation at genes but not TEs in Arabidopsis.
Journal of integrative plant biology
Zhou X,He J,Velanis CN,Zhu Y,He Y,Tang K,Zhu M,Graser L,de Leau E,Wang X,Zhang L,Andy Tao W,Goodrich J,Zhu JK,Zhang CJ
A-11122 was used in Immunoprecipitation to suggest that Harbinger transposon-derived SANT domain-containing proteins are required for histone deacetylation and flowering time in plants.
Sun Aug 01 00:00:00 UTC 2021
Characterization of histone inheritance patterns in the Drosophila female germline.
EMBO reports
Kahney EW,Zion EH,Sohn L,Viets-Layng K,Johnston R,Chen X
A-11122 was used in Immunohistochemistry to combine histone labeling with DNA Oligopaints to distinguish old versus new histones and visualize their inheritance patterns at a single-gene resolution in asymmetrically dividing cells in vivo.
Mon Jul 05 00:00:00 UTC 2021
Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions.
The Journal of cell biology
Kumbhar R,Sanchez A,Perren J,Gong F,Corujo D,Medina F,Devanathan SK,Xhemalce B,Matouschek A,Buschbeck M,Buck-Koehntop BA,Miller KM
A-11122 was used in Immunoprecipitation to reveal the importance of PAR binding and histone variant macroH2A1.2 in KDM5A recognition of DNA lesion sites, driving transcriptional and repair activities at DNA breaks within chromatin that are essential for maintaining genome integrity.
Mon Jul 05 00:00:00 UTC 2021
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
The Journal of cell biology
Wouters R,Michiels C,Sannerud R,Kleizen B,Dillen K,Vermeire W,Ayala AE,Demedts D,Schekman R,Annaert W
A-11122 was used in Immunoprecipitation to conclude that dimeric subcomplexes aided by Sec24 paralog selectivity support a stepwise assembly of γ-secretase, controlling final levels in post-Golgi compartments.
Mon Sep 06 00:00:00 UTC 2021
COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers.
The Journal of cell biology
Shomron O,Nevo-Yassaf I,Aviad T,Yaffe Y,Zahavi EE,Dukhovny A,Perlson E,Brodsky I,Yeheskel A,Pasmanik-Chor M,Mironov A,Beznoussenko GV,Mironov AA,Sklan EH,Patterson GH,Yonemura Y,Sannai M,Kaether C,Hirschberg K
A-11122 was used in Western Blot to monitor cargo selection processes, accumulation, and fission of COPII-free ERES membranes.
Mon Jun 07 00:00:00 UTC 2021
GENOMES UNCOUPLED1-independent retrograde signaling targets the ethylene pathway to repress photomorphogenesis.
Plant physiology
Gommers CMM,Ruiz-Sola MÁ,Ayats A,Pereira L,Pujol M,Monte E
A-11122 was used in Western Blot to show how two apparently different stress responses converge to optimize photomorphogenesis.
Thu Feb 25 00:00:00 UTC 2021
Delta opioid receptor regulation of calcitonin gene-related peptide dynamics in the trigeminal complex.
Pain
Moye LS,Siegersma K,Dripps I,Witkowski W,Mangutov E,Wang D,Scherrer G,Pradhan AA
A-11122 was used in Immunohistochemistry to suggest that DOP agonists inhibit migraine-associated pain by attenuating CGRP release and blocking pronociceptive signaling of the CGRPR.
Sun Aug 01 00:00:00 UTC 2021
The complete cell lineage and MAPK- and Otx-dependent specification of the dopaminergic cells in the Ciona brain.
Development (Cambridge, England)
Oonuma K,Kusakabe TG
A-11122 was used in Immunohistochemistry to establish the cellular and molecular framework for fully understanding the commitment to dopaminergic cells in the simple chordate brain.
Tue Jun 15 00:00:00 UTC 2021
A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rajbhandari AK,Octeau CJ,Gonzalez S,Pennington ZT,Mohamed F,Trott J,Chavez J,Ngyuen E,Keces N,Hong WZ,Neve RL,Waschek J,Khakh BS,Fanselow MS
A-11122 was used in Immunohistochemistry to show that a specific circuitry containing the neuropeptide PACAP and its receptor, PAC1, regulates various aspects of fear, including acquisition, generalization, recall, and extinction in a sexually dimorphic manner, characterizing a novel pathway that modulates traumatic fear.
Wed Apr 14 00:00:00 UTC 2021
Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nakamura Y,Ueno M,Niehaus JK,Lang RA,Zheng Y,Yoshida Y
A-11122 was used in Immunohistochemistry to demonstrate a potential molecular approach to reconstruct motor pathways after SCI.
Wed Dec 15 00:00:00 UTC 2021
Developmental Regulation of Homeostatic Plasticity in Mouse Primary Visual Cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wen W,Turrigiano GG
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest that homeostatic forms of plasticity can be recruited in a modular manner according to the evolving needs of a developing neural circuit.
Wed Dec 01 00:00:00 UTC 2021
A Sexually Dimorphic Olfactory Neuron Mediates Fixed Action Transition during Courtship Ritual in Drosophila melanogaster.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tanaka NK,Hirao T,Chida H,Ejima A
A-11122 was used in Immunohistochemistry to show that lateral antennal lobe tract projection neuron 4 (lPN4) in D. melanogaster functions as an "AND-gate" for volatile and contact chemosensory inputs, mediating the expression of tapping behaviors before unilateral wing extension during male courtship rituals.
Wed Nov 24 00:00:00 UTC 2021
Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in the Drosophila Neuromuscular Circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang Y,Lobb-Rabe M,Ashley J,Anand V,Carrillo RA
A-11122 was used in Immunocytochemistry to study Drosophila neuronal plasticity in response to synapse loss.
Wed Feb 17 00:00:00 UTC 2021
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Journal of virology
Alghamri MS,Sharma P,Williamson TL,Readler JM,Yan R,Rider SD,Hostetler HA,Cool DR,Kolawole AO,Excoffon KJDA
A-11122 was used in Western Blot to show that the interactions between the MAGI-1 PDZ2 domain and CAREx8 would decrease the apical CAREx8 expression level and prevent AdV infection.
Thu Jun 10 00:00:00 UTC 2021
Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus.
Molecular therapy oncolytics
Suzuki T,Uchida H,Shibata T,Sasaki Y,Ikeda H,Hamada-Uematsu M,Hamasaki R,Okuda K,Yanagi S,Tahara H
A-11122 was used in Immunohistochemistry to investigate the in vivo anti-tumor effects of a single-chain antibody for targeting tumor-associated antigens modified with additional mutations conferring syncytium formation - RRsyn-oHSV - using human cancer xenografts in immunodeficient mice.
Fri Sep 24 00:00:00 UTC 2021
Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction.
The Journal of physiology
Teravskis PJ,Oxnard BR,Miller EC,Kemper L,Ashe KH,Liao D
A-11122 was used in Immunocytochemistry-immunoflourescence to study how postsynaptic dysfunction results from a sequential process involving differential phosphorylation in the N-terminal and C-terminal domains in cultured rat hippocampal neurons.
Sat May 01 00:00:00 UTC 2021
The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish.
Frontiers in cell and developmental biology
Hopfenmüller VL,Perner B,Reuter H,Bates TJD,Große A,Englert C
A-11122 was used in Immunohistochemistry to investigate expression domains for Wt1 in the doors hindbrain of zebrafish.
Sat Jan 29 00:00:00 UTC 2022
Slit/Robo Signaling Regulates Multiple Stages of the Development of the Drosophila Motion Detection System.
Frontiers in cell and developmental biology
Guzmán-Palma P,Contreras EG,Mora N,Smith M,González-Ramírez MC,Campusano JM,Sierralta J,Hassan BA,Oliva C
A-11122 was used in Immunohistochemistry to reveal the co-option of the Slit-Robo signaling pathway in distinct developmental stages of a neural lineage.
Thu May 13 00:00:00 UTC 2021
Lyophilized yeast powder for adjuvant free thermostable vaccine delivery.
Applied microbiology and biotechnology
Kumar R,Kharbikar BN
A-11122 was used in a functional assay to show that E. coli curli-green fluorescent fusion protein remains stable in freeze-dried yeast powder for more than 18 and 12 months when stored at 30 °C and 37 °C respectively, to address the pressing need for the development of thermostable vaccines.
Thu Apr 01 00:00:00 UTC 2021
Aberrant cytoplasmic localization of ARID1B activates ERK signaling and promotes oncogenesis.
Journal of cell science
Animireddy S,Kavadipula P,Kotapalli V,Gowrishankar S,Rao S,Bashyam MD
A-11122 was used in Immunocytochemistry to characterize the ARID1B nuclear localization signal.
Fri Feb 26 00:00:00 UTC 2021
Endogenously expressed Ranbp2 is not at the axon initial segment.
Journal of cell science
Ogawa Y,Rasband MN
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate if endogenously expressed Ranbp2 is not found at axon initial segments.
Thu Mar 11 00:00:00 UTC 2021
Rostro-Caudal Specificity of Corticospinal Tract Projections in Mice.
Cerebral cortex (New York, N.Y. : 1991)
Steward O,Yee KM,Metcalfe M,Willenberg R,Luo J,Azevedo R,Martin-Thompson JH,Gandhi SP
A-11122 was used in Immunocytochemistry-immunoflourescence to assess rostro-caudal specificity of corticospinal tract projections from different areas of the cortex by retrograde labeling with fluorogold and retrograde transfection following retro-AAV/Cre injection into the spinal cord of tdT reporter mice.
Wed Mar 31 00:00:00 UTC 2021
Maturation of Complex Synaptic Connections of Layer 5 Cortical Axons in the Posterior Thalamic Nucleus Requires SNAP25.
Cerebral cortex (New York, N.Y. : 1991)
Hayashi S,Hoerder-Suabedissen A,Kiyokage E,Maclachlan C,Toida K,Knott G,Molnár Z
A-11122 was used in Immunomicroscopy to study synapse maturation in the absence of regulated vesicular release.
Wed Mar 31 00:00:00 UTC 2021
Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors.
Human gene therapy
Stone D,Kenkel EJ,Loprieno MA,Tanaka M,De Silva Feelixge HS,Kumar AJ,Stensland L,Obenza WM,Wangari S,Ahrens CY,Murnane RD,Peterson CW,Kiem HP,Huang ML,Aubert M,Hu SL,Jerome KR
A-11122 was used in Immunohistochemistry to investigate whether immunosuppression would allow gene delivery by AAV6 or targeted AAV6 derivatives in seropositive rhesus macaques.
Fri Jan 01 00:00:00 UTC 2021
Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey Central Nervous System.
Human gene therapy
Galvan A,Petkau TL,Hill AM,Korecki AJ,Lu G,Choi D,Rahman K,Simpson EM,Leavitt BR,Smith Y
A-11122 was used in Immunohistochemistry to demonstrate that a single injection in the lateral ventricle is an efficient method to obtain transgene expression in many cortical and subcortical regions, obviating the need of multiple intraparenchymal injections to cover large brain areas.
Tue Jun 01 00:00:00 UTC 2021
A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease.
Journal of inherited metabolic disease
Yap ZY,Strucinska K,Matsuzaki S,Lee S,Si Y,Humphries K,Tarnopolsky MA,Yoon WH
A-11122 was used in Western Blotting to identify two individuals carrying a homozygous missense variant c.959A>G (p.N320S) in the 2-Oxoglutarate dehydrogenase gene.
Mon Mar 01 00:00:00 UTC 2021
Variants of human CLDN9 cause mild to profound hearing loss.
Human mutation
Ramzan M,Philippe C,Belyantseva IA,Nakano Y,Fenollar-Ferrer C,Tona R,Yousaf R,Basheer R,Imtiaz A,Faridi R,Munir Z,Idrees H,Salman M,Nambot S,Vitobello A,Kartti S,Zarrik O,Witmer PD,Sobreria N,Ibrahimi A,Banfi B,Moutton S,Friedman TB,Naz S
A-11122 was used in Western Blot to expand the genotype-phenotype spectrum of CLDN9-associated deafness and describe two different homozygous variants in individuals from two unrelated families affected with prelingual or adolescent-onset hearing loss.
Fri Oct 01 00:00:00 UTC 2021
Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3.
Genetics
Daiber T,VanderZwan-Butler CJ,Bashaw GJ,Evans TA
A-11122 was used in Immunohistochemistry to show that SAX-3 is not subject to endosomal sorting by the negative regulator Commissureless (Comm) in Drosophila neurons in vivo, and that peri-membrane and ectodomain sequences are both required for Comm sorting of Drosophila Robo1.
Wed Mar 31 00:00:00 UTC 2021
Dynein regulates Kv7.4 channel trafficking from the cell membrane.
The Journal of general physiology
van der Horst J,Rognant S,Abbott GW,Ozhathil LC,Hägglund P,Barrese V,Chuang CY,Jespersen T,Davies MJ,Greenwood IA,Gourdon P,Aalkjær C,Jepps TA
A-11122 was used in Western Blot to study the influence of dynein on the microtubule-dependent internalization of the voltage-gated Kv7.4 potassium channel.
Mon Mar 01 00:00:00 UTC 2021
Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract.
Digestion
Aikiyo S,Kishi K,Kaji N,Mikawa S,Kondo M,Shimada S,Hori M
A-11122 was used in Immunocytochemistry to show that 5-HT3AR is highly expressed in the stomach and large intestine and that the activation of 5-HT3AR accelerates gastric emptying and large intestine transit.
Wed Aug 18 00:00:00 UTC 2021
Aversive teaching signals from individual dopamine neurons in larval Drosophila show qualitative differences in their temporal "fingerprint".
The Journal of comparative neurology
Weiglein A,Thoener J,Feldbruegge I,Warzog L,Mancini N,Schleyer M,Gerber B
A-11122 was used in Immunohistochemistry to suggest that heterogeneity in the temporal fingerprint of teaching signals might be a more general principle of reinforcement processing through dopamine neurons.
Sat May 01 00:00:00 UTC 2021
Male-biased protein expression in primordial germ cells, identified through a comparative study of UAS vectors in Drosophila.
Scientific reports
Masukawa M,Ishizaki Y,Miura H,Hayashi M,Ota R,Kobayashi S
A-11122 was used in Immunohistochemistry to show that all three types of UAS vectors were functional in the germline cells of Drosophila embryos and larvae and that the UASt and UASz vectors were active in the germline of the distal tip region in adult testes.
Tue Nov 02 00:00:00 UTC 2021
Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception.
eLife
Yang S,Zhang Y,Yang C,Wu X,El Oud SM,Chen R,Cai X,Wu XS,Lan G,Zheng X
A-11122 was used in Immunocytochemistry-immunoflourescence to report that Interference hedgehog (Ihog) not only forms a Hh receptor complex with Patched to mediate intracellular signaling, but Ihog also engages in trans-homophilic binding leading to cytoneme stabilization in a manner independent of its role as the Hh receptor.
Tue May 18 00:00:00 UTC 2021
α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability.
NPJ Parkinson's disease
Dagra A,Miller DR,Lin M,Gopinath A,Shaerzadeh F,Harris S,Sorrentino ZA,Støier JF,Velasco S,Azar J,Alonge AR,Lebowitz JJ,Ulm B,Bu M,Hansen CA,Urs N,Giasson BI,Khoshbouei H
A-11122 was used in Immunocytochemistry to provide mechanistic insights into the insidious changes in dopaminergic neuronal activity and neuronal loss that characterize Parkinson''s disease progression with significant therapeutic implications.
Wed Aug 18 00:00:00 UTC 2021
Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery.
Brain communications
Smith EJ,Farshim PP,Flomen R,Jones ST,McAteer SJ,Deverman BE,Gradinaru V,Bates GP
A-11122 was used in Immunohistochemistry to allow the rapid comparison of transduction rates between brain regions producing comparable data to more time-consuming approaches.
Sun May 05 00:00:00 UTC 2024
Neonicotinoids disrupt memory, circadian behaviour and sleep.
Scientific reports
Tasman K,Hidalgo S,Zhu B,Rands SA,Hodge JJL
A-11122 was used in Immunohistochemistry to show that disruption of learning, circadian rhythmicity and sleep are likely to have far-reaching detrimental effects on beneficial insects in the field.
Thu Jan 21 00:00:00 UTC 2021
A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila.
Development (Cambridge, England)
Ordway AJ,Teeters GM,Weasner BM,Weasner BP,Policastro R,Kumar JP
A-11122 was used in ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot to investigate Pax6 regulatory roles in drosophila, in organ number regulation.
Sat May 01 00:00:00 UTC 2021
Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron.
Cell reports
Marneros AG
A-11122 was used in Immunohistochemistry to conclude that KCTD1 regulates urinary reabsorption of Mg2+ and Ca2+ by inducing expression of NCC in DCTs and NKCC2/claudin-16/-19 in TALs.
Tue Jan 12 00:00:00 UTC 2021
piRNA-independent transposon silencing by the Drosophila THO complex.
Developmental cell
Zhang G,Yu T,Parhad SS,Ho S,Weng Z,Theurkauf WE
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to show that the thoc7-null mutant combination increases transposon transcription but does not reduce anti-sense piRNAs targeting half of the transcriptionally activated transposon families.
Mon Sep 27 00:00:00 UTC 2021
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Cell death & disease
Pérez-Sisqués L,Sancho-Balsells A,Solana-Balaguer J,Campoy-Campos G,Vives-Isern M,Soler-Palazón F,Anglada-Huguet M,López-Toledano MÁ,Mandelkow EM,Alberch J,Giralt A,Malagelada C
A-11122 was used in Western Blot to investigate the involvement of RTP801 in the pathophysiology of Alzheimer's disease.
Tue Jun 15 00:00:00 UTC 2021
Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice.
Communications biology
Yu TS,Tensaouti Y,Stephanz EP,Chintamen S,Rafikian EE,Yang M,Kernie SG
A-11122 was used in Immunohistochemistry to demonstrate that astrocytic ApoE is required for functional injury-induced neurogenesis following traumatic brain injury.
Thu Nov 18 00:00:00 UTC 2021
Slowpoke functions in circadian output cells to regulate rest:activity rhythms.
PloS one
Ruiz D,Bajwa ST,Vanani N,Bajwa TA,Cavanaugh DJ
A-11122 was used in Immunohistochemistry to demonstrate that slo exerts its effects in multiple components of the circadian circuit, including PI output cells in addition to clock neurons, and we hypothesize that it does so by contributing to the generation of daily neuronal activity rhythms that allow for the propagation of circadian information throughout output circuits.
Tue Oct 19 00:00:00 UTC 2021
δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling.
iScience
Biswas S,Emond MR,Chenoweth KP,Jontes JD
A-11122 was used in Western Blotting to find that δ-protocadherins are novel regulators of Wnt/β-catenin signaling that may control the development of neural circuits by defining a molecular code for the identity of neural progenitor cells and differentially regulating their proliferation.
Fri Aug 20 00:00:00 UTC 2021
Self-organized patterning of cell morphology via mechanosensitive feedback.
eLife
Dye NA,Popović M,Iyer KV,Fuhrmann JF,Piscitello-Gómez R,Eaton S,Jülicher F
A-11122 was used in Immunocytochemistry to present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements.
Fri Mar 26 00:00:00 UTC 2021
FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes.
Nature communications
Miyoshi G,Ueta Y,Natsubori A,Hiraga K,Osaki H,Yagasaki Y,Kishi Y,Yanagawa Y,Fishell G,Machold RP,Miyata M
A-11122 was used in Immunohistochemistry to study dysregulation of FOXG1 expression and how this contributes to autism spectrum disorder-like phenotypes.
Fri Jun 18 00:00:00 UTC 2021
Missense mutation of a conserved residue in UNC-112 (kindlin) eliminates binding to PAT-4 (ILK).
microPublication biology
Qadota H,Oberhauser AF,Benian GM
A-11122 was used in Immunohistochemistry to report identification of a novel UNC-112 mutation of a conserved residue that cannot bind to PAT-4.
Thu Sep 23 00:00:00 UTC 2021
Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity.
The Journal of cell biology
Iemura K,Natsume T,Maehara K,Kanemaki MT,Tanaka K
A-11122 was used in Western Blotting to propose that Aurora A-mediated metaphase Hec1-S55 phosphorylation through chromosome oscillation, together with Hec1-S69 phosphorylation, ensures mitotic fidelity by eliminating erroneous kinetochore-microtubule attachments.
Mon Jul 05 00:00:00 UTC 2021
Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.
The Journal of cell biology
Clay DE,Bretscher HS,Jezuit EA,Bush KB,Fox DT
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal a mechanism for how cells with inactive DSB checkpoints can respond to DNA damage that persists into mitosis.
Mon Dec 06 00:00:00 UTC 2021
Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.
Nature communications
Perez-Frances M,van Gurp L,Abate MV,Cigliola V,Furuyama K,Bru-Tari E,Oropeza D,Carreaux T,Fujitani Y,Thorel F,Herrera PL
A-11122 was used in Immunohistochemistry to present the genetic signature of human and mouse γ-cells.
Thu Jul 22 00:00:00 UTC 2021
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7.
Cell host & microbe
Guérin A,Roy NH,Kugler EM,Berry L,Burkhardt JK,Shin JB,Striepen B
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to delineate the events of host cell invasion and uncover a mechanism unique to Cryptosporidium.
Wed Sep 08 00:00:00 UTC 2021
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7.
Cell host & microbe
Guérin A,Roy NH,Kugler EM,Berry L,Burkhardt JK,Shin JB,Striepen B
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to delineate the events of host cell invasion and uncover a mechanism unique to Cryptosporidium.
Wed Sep 08 00:00:00 UTC 2021
Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity.
PLoS genetics
Garner CM,Spears BJ,Su J,Cseke LJ,Smith SN,Rogan CJ,Gassmann W
A-11122 was used in Immunoprecipitation to show the diverse functions of the transcriptional co-repressor family TOPLESS in Arabidopsis.
Mon Feb 01 00:00:00 UTC 2021
Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth.
International journal of molecular sciences
Pagella P,Nombela-Arrieta C,Mitsiadis TA
A-11122 was used in Immunohistochemistry to show that Cxcl12 is widely expressed in intact and injured teeth and highlight its importance as a key component of the various dental mesenchymal stem cell niches.
Tue Mar 16 00:00:00 UTC 2021
Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Cell reports
Menzel L,Zschummel M,Crowley T,Franke V,Grau M,Ulbricht C,Hauser A,Siffrin V,Bajénoff M,Acton SE,Akalin A,Lenz G,Willimsky G,Höpken UE,Rehm A
A-11122 was used in Immunohistochemistry to show that lymphoma causes severe high endothelial venule regression in mouse models that phenocopies aggressive human B cell lymphomas.
Tue Oct 26 00:00:00 UTC 2021
A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity.
Redox biology
Dapueto R,Rodriguez-Duarte J,Galliussi G,Kamaid A,Bresque M,Batthyány C,López GV,Escande C
A-11122 was used in Immunohistochemistry-wholemount to propose that this novel nitroalkene-Trolox derivative is a suitable tool to tackle acute and chronic inflammation in vitro and in vivo mainly due to inhibition of NF-kB/NLRP3 activation.
Mon Feb 01 00:00:00 UTC 2021
A neural circuit integrates pharyngeal sensation to control feeding.
Cell reports
Yang T,Yuan Z,Liu C,Liu T,Zhang W
A-11122 was used in Immunohistochemistry to reveal the function of pharyngeal mechanoreceptors and their downstream neural circuits in the control of food ingestion.
Tue Nov 09 00:00:00 UTC 2021
Single-cell visualization of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development.
G3 (Bethesda, Md.)
Gallicchio L,Griffiths-Jones S,Ronshaugen M
A-11122 was used in Immunohistochemistry to show that the expression of mir-9a in SOP cells is rapidly lost as Senseless expression increases.
Mon Jan 18 00:00:00 UTC 2021
Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo.
eLife
Xie Y,Budhathoki R,Blankenship JT
A-11122 was used in Immunohistochemistry to present an in-depth characterization of cortical actin cap dynamics and their regulation in vivo.
Wed May 05 00:00:00 UTC 2021
Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
Nature communications
Funato Y,Yamazaki D,Okuzaki D,Yamamoto N,Miki H
A-11122 was used in Western Blot to indicate crucial roles of TRPM6 in the circadian regulation of blood pressure.
Thu Jun 17 00:00:00 UTC 2021
Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.
Nature communications
Grintsevich EE,Ahmed G,Ginosyan AA,Wu H,Rich SK,Reisler E,Terman JR
A-11122 was used in In vivo experiments to conclude that profilin and Mical combine to impair F-actin assembly and promote F-actin disassembly, while concomitantly facilitating cellular remodeling and plasticity.
Mon Sep 20 00:00:00 UTC 2021
Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T-cell responses to acute and chronic viral infection.
European journal of immunology
Aparicio-Domingo P,Cannelle H,Buechler MB,Nguyen S,Kallert SM,Favre S,Alouche N,Papazian N,Ludewig B,Cupedo T,Pinschewer DD,Turley SJ,Luther SA
A-11122 was used in Immunohistochemistry-immunofluorescence to show that LN T-zone fibroblastic reticular cells (FRC) not only regulate the homeostasis of naive T cells but also their expansion and differentiation several days into an antiviral response.
Fri Jan 01 00:00:00 UTC 2021
Male courtship song drives escape responses that are suppressed for successful mating.
Scientific reports
Arez E,Mezzera C,Neto-Silva RM,Aranha MM,Dias S,Moita MA,Vasconcelos ML
A-11122 was used in Western Blot to suggest that courtship song has a dual role, promoting both escape and pause in females and that escape is suppressed by the activity of 70A09 neurons, allowing mating to occur.
Thu Apr 29 00:00:00 UTC 2021
Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.
Developmental biology
Rux D,Helbig K,Koyama E,Pacifici M
A-11122 was used in Immunohistochemistry to demonstrate that Hox11 genes characterize adult, terminally differentiated, articular chondrocytes and maintain region-specificity established in the embryo.
Wed Sep 01 00:00:00 UTC 2021
A medullary centre for lapping in mice.
Nature communications
Dempsey B,Sungeelee S,Bokiniec P,Chettouh Z,Diem S,Autran S,Harrell ER,Poulet JFA,Birchmeier C,Carey H,Genovesio A,McMullan S,Goridis C,Fortin G,Brunet JF
A-11122 was used in Immunohistochemistry to identify one of the subcortical nuclei underpinning a stereotyped feeding behavior.
Tue Nov 02 00:00:00 UTC 2021
DEAD-box helicases modulate dicing body formation in Arabidopsis.
Science advances
Li Q,Liu N,Liu Q,Zheng X,Lu L,Gao W,Liu Y,Liu Y,Zhang S,Wang Q,Pan J,Chen C,Mi Y,Yang M,Cheng X,Ren G,Yuan YW,Zhang X
A-11122 was used in Immunohistochemistry to reveal the key roles of RH6, RH8, and RH12 in modulating D-body formation via LLPSs.
Thu Apr 01 00:00:00 UTC 2021
A novel strategy of selective gene delivery by using a uniform magnetic field.
Biotechnology journal
Dateki M,Imamura O,Arai M,Shimizu H,Takishima K
A-11122 was used in Immunocytochemistry-immunofluorescence to establish a novel procedure for uniform magnetic field-dependent enhancement of transfection efficiency. We examined the effect of a 1.5 mT uniform magnetic field on cellular reactive oxygen species (ROS) level and transfection efficiency mediated by a ROS-sensitive transfection carrier.
Thu Apr 01 00:00:00 UTC 2021
Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line.
International journal of molecular sciences
Burtscher I,Tarquis-Medina M,Salinno C,Schirge S,Beckenbauer J,Bakhti M,Lickert H
A-11122 was used in Western Blot to summarize that the generation of the Nkx6-1-VF reporter line reflects the expression pattern and dynamics of the endogenous protein and thus provides a unique tool to study the spatio-temporal expression pattern of this TF during organ development and enables isolation and tracking of Nkx6-1-expressing cells such as pancreatic β-cells, but also neurons and motor neurons in health and disease.
Fri Mar 26 00:00:00 UTC 2021
Comprehensive topographical map of the serotonergic fibers in the male mouse brain.
The Journal of comparative neurology
Awasthi JR,Tamada K,Overton ETN,Takumi T
A-11122 was used in Immunohistochemistry-immunofluorescence to provide novel, regionally specific insights on the distribution map of serotonergic fibers using transgenic mouse.
Sat May 01 00:00:00 UTC 2021
Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms.
iScience
Nettnin EA,Sallese TR,Nasseri A,Saurabh S,Cavanaugh DJ
A-11122 was used in Immunohistochemistry-immunofluorescence to clarify the role of the dorsal neuron 1 (DN1) population of clock neurons in the transmission of circadian information by the Drosophila core clock network.
Fri Sep 24 00:00:00 UTC 2021
The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.
Scientific reports
Kozono T,Sato H,Okumura W,Jogano C,Tamura-Nakano M,Kawamura YI,Rohrer J,Tonozuka T,Nishikawa A
A-11122 was used in Western Blotting to show that the N-terminal region of Jaw1 inhibits the formation of OSER as an IDR to maintain the homeostatic localization of interactors on the ER membrane.
Tue Jan 12 00:00:00 UTC 2021
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
Nature communications
de la Fuente-Alonso A,Toral M,Alfayate A,Ruiz-Rodríguez MJ,Bonzón-Kulichenko E,Teixido-Tura G,Martínez-Martínez S,Méndez-Olivares MJ,López-Maderuelo D,González-Valdés I,Garcia-Izquierdo E,Mingo S,Martín CE,Muiño-Mosquera L,De Backer J,Nistal JF,Forteza A,Evangelista A,Vázquez J,Campanero MR,Redondo JM
A-11122 was used in Immunohistochemistry to identify potential biomarkers for monitoring Marfan Syndrome in patients and urge evaluation of cGMP-dependent protein kinase and soluble guanylate cyclase as therapeutic targets.
Tue May 11 00:00:00 UTC 2021
The amyloid precursor protein is a conserved Wnt receptor.
eLife
Liu T,Zhang T,Nicolas M,Boussicault L,Rice H,Soldano A,Claeys A,Petrova I,Fradkin L,De Strooper B,Potier MC,Hassan BA
A-11122 was used in Immunocytochemistry to show that APP binds the Wnt ligands Wnt3a and Wnt5a and that this binding regulates APP protein levels.
Thu Sep 09 00:00:00 UTC 2021
Optimized Immunostaining of Embryonic and Early Postnatal Mouse Brain Sections.
Bio-protocol
Harb K,Bertacchi M,Studer M
A-11122 was used in Immunohistochemistry to present a detailed protocol, suitable for both thin cryostat sections and thick vibratome sections, which has successfully worked for a wide range of antibodies directed against key molecular players of neocortical development.
Tue Jan 05 00:00:00 UTC 2021
Light-triggered and phosphorylation-dependent 14-3-3 association with NON-PHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism.
Nature communications
Reuter L,Schmidt T,Manishankar P,Throm C,Keicher J,Bock A,Droste-Borel I,Oecking C
A-11122 was used in Western Blot to demonstrate that blue light induces an immediate phosphorylation of a C-terminal 14-3-3 binding motif in NPH3.
Thu Oct 21 00:00:00 UTC 2021
GmKIX8-1 regulates organ size in soybean and is the causative gene for the major seed weight QTL qSw17-1.
The New phytologist
Nguyen CX,Paddock KJ,Zhang Z,Stacey MG
A-11122 was used in Western Blot to show that molecular analysis of soybean germplasms harboring the qSw17-1 QTL for the big-seeded phenotype indicated that reduced expression of GmKIX8-1 is the genetic basis of the qSw17-1 phenotype.
Fri Jan 01 00:00:00 UTC 2021
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
eLife
Onur TS,Laitman A,Zhao H,Keyho R,Kim H,Wang J,Mair M,Wang H,Li L,Perez A,de Haro M,Wan YW,Allen G,Lu B,Al-Ramahi I,Liu Z,Botas J
A-11122 was used in Western Blotting to investigate the contributions of glia to Huntington's disease.
Mon Apr 19 00:00:00 UTC 2021
The bZIP Transcription Factor HapX Is Post-Translationally Regulated to Control Iron Homeostasis in Aspergillus fumigatus.
International journal of molecular sciences
López-Berges MS,Scheven MT,Hortschansky P,Misslinger M,Baldin C,Gsaller F,Werner ER,Krüger T,Kniemeyer O,Weber J,Brakhage AA,Haas H
A-11122 was used in Western Blot to elucidate the role of the bZIP transcription factor, HapX, in the regulation of iron homeostasis in Aspergillus fumigatus.
Tue Jul 20 00:00:00 UTC 2021
Cannabinoid and planar cell polarity signaling converges to direct placentation.
Proceedings of the National Academy of Sciences of the United States of America
Kim YS,Li Y,Yuan J,Borg JP,Sun X,Dey SK
A-11122 was used in Western Blotting to show that organized PCP in trophoblasts is indispensable for their directed movement and that CB1 exerts its function by direct interaction with membrane proteins other than its canonical G protein-coupled receptor role.
Tue Sep 21 00:00:00 UTC 2021
Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.
Frontiers in pharmacology
Sen E,Kota KP,Panchal RG,Bavari S,Kiris E
A-11122 was used in Western Blotting to study a focused ubiquitin-proteasome pathway inhibitor library and identified potential lead compounds affecting BoNT/A mediated SNAP-25 cleavage in neurons in pre-intoxication conditions.
Sat Aug 17 00:00:00 UTC 2024
Identification of Two Dysfunctional Variants in the ABCG2 Urate Transporter Associated with Pediatric-Onset of Familial Hyperuricemia and Early-Onset Gout.
International journal of molecular sciences
Toyoda Y,Pavelcová K,Bohatá J,Ješina P,Kubota Y,Suzuki H,Takada T,Stiburkova B
A-11122 was used in Western Blotting to describe a representative case of familial pediatric-onset hyperuricemia and early-onset gout associated with a dysfunctional ABCG2, i.e., a clinical history of three generations of one Czech family with biochemical and molecular genetic findings.
Tue Feb 16 00:00:00 UTC 2021
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued.
Molecular brain
Suh BK,Lee SA,Park C,Suh Y,Kim SJ,Woo Y,Nhung TTM,Lee SB,Mun DJ,Goo BS,Choi HS,Kim SJ,Park SK
A-11122 was used in Western Blotting to suggest that dysbindin forms a functional complex with p150glued that regulates axonal mitochondrial transport, thereby affecting presynaptic calcium homeostasis.
Mon Jan 18 00:00:00 UTC 2021
Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons.
eLife
Van Battum E,Heitz-Marchaland C,Zagar Y,Fouquet S,Kuner R,Chédotal A
A-11122 was used in Immunocytochemistry to suggest that Plexin-B2 restricts CGN motility and might have a function in cytokinesis.
Tue Jun 08 00:00:00 UTC 2021
RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility.
PLoS genetics
Chen P,Luo Y,Aravin AA
A-11122 was used in Chromatin immunoprecipitation to investigate how piRNA cluster transcription is regulated in the male germline.
Wed Sep 01 00:00:00 UTC 2021
Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
eLife
Chaudhari K,Gorla M,Chang C,Kania A,Bashaw GJ
A-11122 was used in Western Blot to investigate the heteropentameric Scar/Wave Regulatory Complex as an effector of Robo signalling.
Mon Apr 12 00:00:00 UTC 2021
Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
eLife
Chaudhari K,Gorla M,Chang C,Kania A,Bashaw GJ
A-11122 was used in Western Blot to investigate the heteropentameric Scar/Wave Regulatory Complex as an effector of Robo signalling.
Mon Apr 12 00:00:00 UTC 2021
Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.
eLife
Chaudhari K,Gorla M,Chang C,Kania A,Bashaw GJ
A-11122 was used in Western Blot to investigate the heteropentameric Scar/Wave Regulatory Complex as an effector of Robo signalling.
Mon Apr 12 00:00:00 UTC 2021
polished rice mediates ecdysone-dependent control of Drosophila embryonic organogenesis.
Genes to cells : devoted to molecular & cellular mechanisms
Taira Y,Wada H,Hayashi S,Kageyama Y
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that ecdysone and its downstream target pri play essential roles in tracheal development by modulating cell fate decision.
Sat May 01 00:00:00 UTC 2021
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Cell reports
Azzoni E,Frontera V,Anselmi G,Rode C,James C,Deltcheva EM,Demian AS,Brown J,Barone C,Patelli A,Harman JR,Nicholls M,Conway SJ,Morrissey E,Jacobsen SEW,Sparrow DB,Harris AL,Enver T,de Bruijn MFTR
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate how and when the onset of circulation affects Hematopoietic stem cells emergence.
Tue Dec 14 00:00:00 UTC 2021
Replication dynamics of recombination-dependent replication forks.
Nature communications
Naiman K,Campillo-Funollet E,Watson AT,Budden A,Miyabe I,Carr AM
A-11122 was used in ChIP assay to show that the leading strand initiates replication at the same position, signifying the stability of the 3' single strand in the context of increased resection.
Wed Feb 10 00:00:00 UTC 2021
Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation.
eLife
Singh A,Hulsmeier J,Kandi AR,Pothapragada SS,Hillebrand J,Petrauskas A,Agrawal K,Rt K,Thiagarajan D,Jayaprakashappa D,VijayRaghavan K,Ramaswami M,Bakthavachalu B
A-11122 was used in Immunohistochemistry to increase the understanding of neuronal translational control mechanisms and inform strategies for Atx2-based interventions under development for neurodegenerative disease.
Wed Mar 10 00:00:00 UTC 2021
SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase.
Cell reports
Choi WY,Kim S,Aurass P,Huo W,Creasey EA,Edwards M,Lowe M,Isberg RR
A-11122 was used in Pull-Down Assay to show that SdhA hijacking of OCRL is associated with blocking trafficking events that disrupt the pathogen vacuole.
Tue Nov 02 00:00:00 UTC 2021
Metastasis suppressor 1 interacts with α-actinin 4 to affect its localization and regulate formation of membrane ruffling.
Cytoskeleton (Hoboken, N.J.)
Liang L,Liang X,Jiang P,Zhou L,Zhong L,Wang M,Lin S,Guo Z,Yu J,Yang C,Chen Y,Zhuo C,Chen P,Wang Y
A-11122 was used in Western Blotting to indicate that MTSS1 might recruit cytoplasmic ACTN4 to the cell periphery and regulate cytoskeleton dynamics to restrict its performance in membrane ruffling.
Thu Jul 01 00:00:00 UTC 2021
Metastasis suppressor 1 interacts with α-actinin 4 to affect its localization and regulate formation of membrane ruffling.
Cytoskeleton (Hoboken, N.J.)
Liang L,Liang X,Jiang P,Zhou L,Zhong L,Wang M,Lin S,Guo Z,Yu J,Yang C,Chen Y,Zhuo C,Chen P,Wang Y
A-11122 was used in Western Blotting to indicate that MTSS1 might recruit cytoplasmic ACTN4 to the cell periphery and regulate cytoskeleton dynamics to restrict its performance in membrane ruffling.
Thu Jul 01 00:00:00 UTC 2021
Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans.
eLife
Yamamoto I,Zhang K,Zhang J,Vorontsov E,Shibuya H
A-11122 was used in Western Blot, Immunocytochemistry to suggest that DTN-1 and DTN-2 are core shelterin components in C. elegans telomeres that act as negative regulators of telomere length and are essential for germline immortality.
Thu Jan 21 00:00:00 UTC 2021
Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans.
eLife
Yamamoto I,Zhang K,Zhang J,Vorontsov E,Shibuya H
A-11122 was used in Western Blot, Immunocytochemistry to suggest that DTN-1 and DTN-2 are core shelterin components in C. elegans telomeres that act as negative regulators of telomere length and are essential for germline immortality.
Thu Jan 21 00:00:00 UTC 2021
Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input.
Journal of neurophysiology
Fanning AS,Shakhawat AM,Raymond JL
A-11122 was used in Immunohistochemistry-immunofluorescence to report that both visual and nonvisual inputs can elicit robust calcium responses in the Purkinje cells, suggesting that the instructive signals guiding oculomotor plasticity are multimodal.
Fri Oct 01 00:00:00 UTC 2021
Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients.
Frontiers in cell and developmental biology
Bharat V,Hsieh CH,Wang X
A-11122 was used in Western Blotting to report that, in MAPT patients' fibroblasts, disease-causing MAPT mutations compromise early events of mitophagy.
Fri Feb 24 00:00:00 UTC 2023
Rapid evolution of blood-brain-barrier-penetrating AAV capsids by RNA-driven biopanning.
Molecular therapy. Methods & clinical development
Nonnenmacher M,Wang W,Child MA,Ren XQ,Huang C,Ren AZ,Tocci J,Chen Q,Bittner K,Tyson K,Pande N,Chung CH,Paul SM,Hou J
A-11122 was used in Immunohistochemistry to developed a directed evolution approach based on recovery of capsid library RNA transcribed from CNS-restricted promoters to identified engineered capsids with improved blood-brain barrier (BBB) penetration and CNS tropism.
Fri Mar 12 00:00:00 UTC 2021
A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila.
eLife
Lee K,Doe CQ
A-11122 was used in Immunocytochemistry to utilize a well-characterized neural circuit in the Drosophila larva: the moonwalker descending neuron (MDN) circuit.
Wed Jul 14 00:00:00 UTC 2021
Surface Modification of E. coli Outer Membrane Vesicles with Glycosylphosphatidylinositol-Anchored Proteins: Generating Pro/Eukaryote Chimera Constructs.
Membranes
Zaruba M,Roschitz L,Sami H,Ogris M,Gerner W,Metzner C
A-11122 was used in Western Blot to show the functional surface modification of E. coli outer membrane vesicles with glycosylphosphatidylinositol (GPI)-anchored protein, exploiting a process described as molecular painting or protein engineering in eukaryotic membranes, whereby the lipid part of the GPI anchor inserts in cell membranes.
Fri Jun 04 00:00:00 UTC 2021
BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Nature communications
Ghouil R,Miron S,Koornneef L,Veerman J,Paul MW,Le Du MH,Sleddens-Linkels E,van Rossum-Fikkert SE,van Loon Y,Felipe-Medina N,Pendas AM,Maas A,Essers J,Legrand P,Baarends WM,Kanaar R,Zinn-Justin S,Zelensky AN
A-11122 was used in Western Blot to investigate if the high-affinity oligomerisation-inducing BRCA2-HSF2BP interaction is required for RAD51 and DMC1 recombinase localization in meiotic homologous recombination.
Thu Jul 29 00:00:00 UTC 2021
Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms.
Life science alliance
Chung WC,Challagundla L,Zhou Y,Li M,Atfi A,Xu K
A-11122 was used in Immunohistochemistry to conclude that Jag1 can act as a tumor suppressor in the pancreas by delaying precursor lesions, whereas loss of Jag1 promoted a phenotypic switch from malignant carcinoma to benign cystic lesions.
Mon Feb 01 00:00:00 UTC 2021
Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.
Science advances
Yoshioka K,Nagahisa H,Miura F,Araki H,Kamei Y,Kitajima Y,Seko D,Nogami J,Tsuchiya Y,Okazaki N,Yonekura A,Ohba S,Sumita Y,Chiba K,Ito K,Asahina I,Ogawa Y,Ito T,Ohkawa Y,Ono Y
A-11122 was used in Immunocytochemistry to investigate if Hox gene expression profiles instill the embryonic history in satellite cells as positional memory, potentially modulating region-specific pathophysiology in adult muscles.
Tue Jun 01 00:00:00 UTC 2021
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Alzheimer's & dementia (New York, N. Y.)
Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q
A-11122 was used in Immunohistochemistry to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.
Fri Apr 05 00:00:00 UTC 2024
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Nature communications
Heredia F,Volonté Y,Pereirinha J,Fernandez-Acosta M,Casimiro AP,Belém CG,Viegas F,Tanaka K,Menezes J,Arana M,Cardoso GA,Macedo A,Kotowicz M,Prado Spalm FH,Dibo MJ,Monfardini RD,Torres TT,Mendes CS,Garelli A,Gontijo AM
A-11122 was used in Immunohistochemistry to reveal that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.
Mon Jun 07 00:00:00 UTC 2021
Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila.
Cell reports
Matinyan N,Karkhanis MS,Gonzalez Y,Jain A,Saltzman A,Malovannaya A,Sarrion-Perdigones A,Dierick HA,Venken KJT
A-11122 was used in Immunohistochemistry-immunofluorescence to describe a drug-based genetic platform consisting of four selection and two counterselection markers, eliminating the need to screen for modified progeny.
Tue Sep 14 00:00:00 UTC 2021
Parahippocampal latrophilin-2 (ADGRL2) expression controls topographical presubiculum to entorhinal cortex circuit connectivity.
Cell reports
Donohue JD,Amidon RF,Murphy TR,Wong AJ,Liu ED,Saab L,King AJ,Pae H,Ajayi MT,Anderson GR
A-11122 was used in Immunohistochemistry to reveal Lphn2 to be selectively expressed by defined cell types and essential for MEC-PrS circuit connectivity.
Tue Nov 23 00:00:00 UTC 2021
Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration.
Cell reports
Chia S,Leung T,Tan I
A-11122 was used in Immunocytochemistry-immunofluorescence to reveal an essential role for LRAP35a in coordinating lamellar contractility and microtubule polarization in cell migration.
Tue Sep 14 00:00:00 UTC 2021
Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis.
Developmental biology
Sallee JL,Crawford JM,Singh V,Kiehart DP
A-11122 was used in Immunocytochemistry-immunofluorescence to indicate that ck/MyoVIIA plays a key role in the formation and/or organization of actin filament bundles, which drive proper shape of cellular projections.
Mon Feb 01 00:00:00 UTC 2021
fruitless tunes functional flexibility of courtship circuitry during development.
eLife
Chen J,Jin S,Chen D,Cao J,Ji X,Peng Q,Pan Y
A-11122 was used in Immunohistochemistry to show that fruM is not absolutely necessary for courtship but is critical during development to build a sex circuitry with reduced flexibility and enhanced efficiency, and provide a new view about how fruM tunes functional flexibility of a sex circuitry instead of switching on its function as conventionally viewed.
Tue Jan 19 00:00:00 UTC 2021
insomniac links the development and function of a sleep-regulatory circuit.
eLife
Li Q,Jang H,Lim KY,Lessing A,Stavropoulos N
A-11122 was used in Immunohistochemistry to link neurogenesis and postmitotic development of sleep-regulatory neurons to their adult function and suggest that developmental perturbations of circuits that couple sensory inputs and sleep may underlie sleep dysfunction in neurodevelopmental disorders.
Wed Dec 15 00:00:00 UTC 2021
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.
Life science alliance
Rivosecchi J,Jost D,Vachez L,Gautier FD,Bernard P,Vanoosthuyse V
A-11122 was used in ChIP assay to strengthen the idea that dense arrays of proteins tightly bound to DNA alter the distribution of condensin on chromosomes.
Tue Jun 01 00:00:00 UTC 2021
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
Translational psychiatry
Lee SB,Park J,Kwak Y,Park YU,Nhung TTM,Suh BK,Woo Y,Suh Y,Cho E,Cho S,Park SK
A-11122 was used in Immunoprecipitation to demonstrate that the oscillation of DISC1 expression is under the control of CLOCK and BMAL1, and that DISC1 contributes to the core circadian system by regulating BMAL1 stability.
Thu Feb 04 00:00:00 UTC 2021
A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel.
Frontiers in physiology
Zheng Y,Wan X,Yang D,Ramirez-Navarro A,Liu H,Fu JD,Deschênes I
A-11122 was used in Immunoprecipitation to summarize that the HF-associated splice variant Nav1.5-G1642X suppresses sodium currents in heart failure patients through a mechanism involving coupled-gating with the wildtype sodium channel.
Sun Mar 31 00:00:00 UTC 2024
RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Neuropathology and applied neurobiology
Jang YN,Jang H,Kim GH,Noh JE,Chang KA,Lee KJ
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to demonstrate that the upregulation of RAPGEF2 levels mediates Aβ oligomer-induced synaptic and cognitive disturbances in the AD hippocampus.
Sun Aug 01 00:00:00 UTC 2021
CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice.
Molecular therapy. Methods & clinical development
Stone D,Long KR,Loprieno MA,De Silva Feelixge HS,Kenkel EJ,Liley RM,Rapp S,Roychoudhury P,Nguyen T,Stensland L,Colón-Thillet R,Klouser LM,Weber ND,Le C,Wagoner J,Goecker EA,Li AZ,Eichholz K,Corey L,Tyrrell DL,Greninger AL,Huang ML,Polyak SJ,Aubert M,Sagartz JE,Jerome KR
A-11122 was used in Immunohistochemistry to provide evidence for the feasibility and safety of in vivo gene editing for chronic HBV infections.
Fri Mar 12 00:00:00 UTC 2021
Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels.
eLife
Stevens SR,Longley CM,Ogawa Y,Teliska LH,Arumanayagam AS,Nair S,Oses-Prieto JA,Burlingame AL,Cykowski MD,Xue M,Rasband MN
A-11122 was used in Western Blot to investigate if Ankyrin-R regulates Pv+ fast-spiking interneuron function by organizing ion channels, cell adhesion molecules, and perineuronal nets, and linking these to the underlying β1 spectrin-based cytoskeleton.
Mon Jun 28 00:00:00 UTC 2021
A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes.
Nature communications
Guo W,Fan S,Xiao D,Dong H,Xu G,Wan Z,Ma Y,Wang Z,Xue T,Zhou Y,Li Y,Xiong W
A-11122 was used in Immunohistochemistry to show a functional role of the reticulotegmental nucleus in startle reflex.
Thu Nov 04 00:00:00 UTC 2021
Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.
Cells
Oláh J,Lehotzky A,Szénási T,Ovádi J
A-11122 was used in Western Blot to reveal the protective effect of DJ-1 against toxic SYN assemblies, which assigns a new function to the antioxidant sensor DJ-1.
Wed Oct 27 00:00:00 UTC 2021
A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS.
eLife
Mark B,Lai SL,Zarin AA,Manning L,Pollington HQ,Litwin-Kumar A,Cardona A,Truman JW,Doe CQ
A-11122 was used in Immunohistochemistry to demonstrate that the mechanisms specifying neuronal diversity also govern circuit formation and function, and that these principles are broadly applicable throughout the nervous system.
Tue May 11 00:00:00 UTC 2021
Distinct Opsin 3 (Opn3) Expression in the Developing Nervous System during Mammalian Embryogenesis.
eNeuro
Davies WIL,Sghari S,Upton BA,Nord C,Hahn M,Ahlgren U,Lang RA,Gunhaga L
A-11122 was used in Immunohistochemistry to monitor cell body expression and axonal projections during embryonic and early postnatal to adult stages.
Wed Oct 20 00:00:00 UTC 2021
Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
Stem cell reports
Resnik-Docampo M,Cunningham KM,Ruvalcaba SM,Choi C,Sauer V,Jones DL
A-11122 was used in Immunohistochemistry to show that the septate junction (SJ) protein Neuroglian (Nrg) is expressed in intestinal stem cells (ISCs) and enteroblasts (EBs) within the fly intestine.
Tue Jun 08 00:00:00 UTC 2021
Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway.
iScience
Sakai Y,Li H,Inaba H,Funayama Y,Ishimori E,Kawatake-Kuno A,Yamagata H,Seki T,Hobara T,Nakagawa S,Watanabe Y,Tomita S,Murai T,Uchida S
A-11122 was used in Immunohistochemistry to elucidate the mechanisms of ventral hippocampus and gene-environment cross-talk implicated in the pathophysiology of depression.
Fri May 21 00:00:00 UTC 2021
Arabidopsis seedling establishment under waterlogging requires ABCG5-mediated formation of a dense cuticle layer.
The New phytologist
Lee EJ,Kim KY,Zhang J,Yamaoka Y,Gao P,Kim H,Hwang JU,Suh MC,Kang B,Lee Y
A-11122 was used in Western Blotting to indicate that proper development of plants under waterlogged conditions requires the dense cuticle layer formed by ABCG5 activity.
Fri Jan 01 00:00:00 UTC 2021
Bimolecular Fluorescence Complementation (BiFC) and Multiplexed Imaging of Protein-Protein Interactions in Human Living Cells.
Methods in molecular biology (Clifton, N.J.)
Jia Y,Bleicher F,Reboulet J,Merabet S
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Inhibition Assay to analyze protein-protein interactions in live human cultured cells via bimolecular fluorescence complementation (BiFC).
Wed Sep 01 00:00:00 UTC 2021
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
The Journal of biological chemistry
Jia R,Bonifacino JS
A-11122 was used in Western Blot to identify mechanisms capable of counteracting the targeting of LC3B for proteasomal degradation by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin ligase BIRC6, which reduces autophagic activity under stress.
Fri Aug 27 00:00:00 UTC 2021
Metallo-β-lactamase domain-containing protein 2 is S-palmitoylated and exhibits acyl-CoA hydrolase activity.
The Journal of biological chemistry
Malgapo MIP,Safadi JM,Linder ME
A-11122 was used in Western Blotting to confirm that MBLAC2 is palmitoylated and identify the likely S-palmitoylation site as Cys254.
Tue Aug 24 00:00:00 UTC 2021
Capsid-specific nanobody effects on HIV-1 assembly and infectivity.
Virology
Alfadhli A,Romanaggi C,Barklis RL,Merutka I,Bates TA,Tafesse FG,Barklis E
A-11122 was used in Western Blotting to demonstrate the feasibility of Gag-targeted nanobody inhibition of HIV-1.
Fri Oct 01 00:00:00 UTC 2021
Probing the biogenesis pathway and dynamics of thylakoid membranes.
Nature communications
Huokko T,Ni T,Dykes GF,Simpson DM,Brownridge P,Conradi FD,Beynon RJ,Nixon PJ,Mullineaux CW,Zhang P,Liu LN
A-11122 was used in Western Blot to study the biogenesis and maturation process of thylakoid membranes.
Wed Jun 09 00:00:00 UTC 2021
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Acta neuropathologica communications
Lehmkuhl EM,Loganathan S,Alsop E,Blythe AD,Kovalik T,Mortimore NP,Barrameda D,Kueth C,Eck RJ,Siddegowda BB,Joardar A,Ball H,Macias ME,Bowser R,Van Keuren-Jensen K,Zarnescu DC
A-11122 was used in RNA Immunoprecipitation to investigate if Dlp/GPC6 is a novel, physiologically relevant target of TDP-43 proteinopathy.
Wed Mar 24 00:00:00 UTC 2021
Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish.
Biology open
Lepanto P,Levin-Ferreyra F,Koziol U,Malacrida L,Badano JL
A-11122 was used in Immunohistochemistry to present the characterization of a novel adipocyte-specific label in zebrafish and uncovers previously unknown aspects of in vivo adipogenesis.
Wed Sep 15 00:00:00 UTC 2021
Interplay between Pds5 and Rec8 in regulating chromosome axis length and crossover frequency.
Science advances
Song M,Zhai B,Yang X,Tan T,Wang Y,Yang X,Tan Y,Chu T,Cao Y,Song Y,Wang S,Zhang L
A-11122 was used in Immunocytochemistry-immunoflourescence to show that only ~20% of wild-type level of Pds5 is required for homolog pairing and that higher levels of Pds5 dosage-dependently regulate axis length and crossover frequency.
Mon Mar 01 00:00:00 UTC 2021
Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex.
eLife
Lin JY,Mukherjee N,Bernstein MJ,Katz DB
A-11122 was used in Immunohistochemistry to suggest that BLA 'organizes' behavior-related GC taste dynamics.
Fri May 21 00:00:00 UTC 2021
ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival.
The Journal of cell biology
Kim J,Kim S,Nahm M,Li TN,Lin HC,Kim YD,Lee J,Yao CK,Lee S
A-11122 was used in Western Blotting to demonstrate that dALS2 directs early to late endosome trafficking and that the dFz2 C terminus is cleaved in late endosomes.
Mon May 03 00:00:00 UTC 2021
Using the Drosophila Transcriptional Reporter of Intracellular Calcium (TRIC) to examine lasting ethanol-induced changes in neuroexcitability.
microPublication biology
Merriman K,Petruccelli E
A-11122 was used in Immunohistochemistry to examine pan-neuronal and dopaminergic cells with transcriptional reporter of intracellular calcium to test the hypothesis that ethanol exposure causes lasting changes in adult drosophila brain neuroexcitability.
Thu Sep 30 00:00:00 UTC 2021
The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.
Development (Cambridge, England)
Grant ZL,Hickey PF,Abeysekera W,Whitehead L,Lewis SM,Symons RCA,Baldwin TM,Amann-Zalcenstein D,Garnham AL,Naik SH,Smyth GK,Thomas T,Voss AK,Coultas L
A-11122 was used in Immunohistochemistry to investigate the role of the histone acetyltransferase HBO1 (KAT7), which is important for activating genes during development and for histone H3 lysine 14 acetylation (H3K14ac).
Fri Oct 15 00:00:00 UTC 2021
Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1.
Open biology
Hwang J,Park K,Lee GY,Yoon BY,Kim H,Roh SH,Lee BC,Kim K,Lim HH
A-11122 was used in Immunocytochemistry-immunofluorescence to provide a basis for both the high-resolution structural determination and functional characterization of the MLC1 protein.
Wed Dec 01 00:00:00 UTC 2021
Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders.
Molecular genetics and metabolism
Briscione MA,Dinasarapu AR,Bagchi P,Donsante Y,Roman KM,Downs AM,Fan X,Hoehner J,Jinnah HA,Hess EJ
A-11122 was used in Immunohistochemistry to study the differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia.
Sun Aug 01 00:00:00 UTC 2021
Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.
Nature communications
Xiao L,Merullo DP,Koch TMI,Cao M,Co M,Kulkarni A,Konopka G,Roberts TF
A-11122 was used in Western Blot to demonstrate discrete circuit origins for the dysfluent repetition of vocal elements in songbirds, with implications for speech disorders.
Tue May 11 00:00:00 UTC 2021
Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.
Nature communications
Xiao L,Merullo DP,Koch TMI,Cao M,Co M,Kulkarni A,Konopka G,Roberts TF
A-11122 was used in Western Blot to demonstrate discrete circuit origins for the dysfluent repetition of vocal elements in songbirds, with implications for speech disorders.
Tue May 11 00:00:00 UTC 2021
Functional interpretation of ATAD3A variants in neuro-mitochondrial phenotypes.
Genome medicine
Yap ZY,Park YH,Wortmann SB,Gunning AC,Ezer S,Lee S,Duraine L,Wilichowski E,Wilson K,Mayr JA,Wagner M,Li H,Kini U,Black ED,Monaghan KG,Lupski JR,Ellard S,Westphal DS,Harel T,Yoon WH
A-11122 was used in Immunohistochemistry to expand the allelic spectrum of ATAD3A variants and exemplify the use of a functional assay in Drosophila to aid variant interpretation.
Mon Apr 12 00:00:00 UTC 2021
A midbrain dynorphin circuit promotes threat generalization.
Current biology : CB
Fellinger L,Jo YS,Hunker AC,Soden ME,Elum J,Juarez B,Zweifel LS
A-11122 was used in Immunohistochemistry to demonstrate that conditioned threat discrimination has an inverted "U" relationship with threat intensity and establish a role for KOR/Dyn signaling in the midbrain for promoting threat generalization.
Mon Oct 11 00:00:00 UTC 2021
Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.
Nature communications
Liu X,Pu W,He L,Li Y,Zhao H,Li Y,Liu K,Huang X,Weng W,Wang QD,Shen L,Zhong T,Sun K,Ardehali R,He B,Zhou B
A-11122 was used in Immunocytochemistry to develop a genetic approach for a temporally seamless recording of cardiomyocyte-specific cell-cycle activity in vivo.
Fri Oct 01 00:00:00 UTC 2021
Amygdala Underlies the Environment Dependency of Defense Responses Induced via Superior Colliculus.
Frontiers in neural circuits
Isa K,Tokuoka K,Ikeda S,Karimi S,Kobayashi K,Sooksawate T,Isa T
A-11122 was used in Immunohistochemistry to test a hypothesis that the amygdala is involved in such environment dependency of the innate defense responses.
Thu Jan 27 00:00:00 UTC 2022
Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse.
Frontiers in immunology
González-Mancha N,Rodríguez-Rodríguez C,Alcover A,Merida I
A-11122 was used in Western Blot to show that sorting nexin 27 modulates immune synapse organisation through regulated trafficking of cargoes in T lymphocytes.
Mon Mar 07 00:00:00 UTC 2022
Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice.
eLife
Aksoy-Aksel A,Gall A,Seewald A,Ferraguti F,Ehrlich I
A-11122 was used in Immunocytochemistry to provide novel insights into dopaminergic mechanisms shaping the activity balance between distinct ITC clusters that could support their opposing roles in fear behavior.
Mon May 24 00:00:00 UTC 2021
Chronic exercise training activates histone turnover in mouse skeletal muscle fibers.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ohsawa I,Kawano F
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, ChIP Assay to reveal that 4 weeks of running training activates histone turnover in skeletal muscle fibers, loosening the nucleosomes and enhancing gene responses to exercise.
Thu Apr 01 00:00:00 UTC 2021
BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling.
Cell reports
Aihara S,Fujimoto S,Sakaguchi R,Imai T
A-11122 was used in Immunohistochemistry to screen for cell surface receptors that control the dendrite remodeling process in mitral cells.
Tue Jun 22 00:00:00 UTC 2021
Human Respiratory Syncytial Virus Subgroup A and B Infections in Nasal, Bronchial, Small-Airway, and Organoid-Derived Respiratory Cultures.
mSphere
Rijsbergen LC,Lamers MM,Comvalius AD,Koutstaal RW,Schipper D,Duprex WP,Haagmans BL,de Vries RD,de Swart RL
A-11122 was used in Immunohistochemistry (Paraffin) to compare the replicative fitness and HRSV-induced innate cytokine responses of HRSV-A and HRSV-B strains in disease-relevant cell culture models.
Wed May 12 00:00:00 UTC 2021
Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells.
Cell reports
Kim JH,Hanlon CD,Vohra S,Devreotes PN,Andrew DJ
A-11122 was used in ChIP Assay, Immunocytochemistry, Immunohistochemistry, Western Blot to propose that Tre1 functions as a master helmsman in germ cell (GC) navigation by integrating extracellular signals to induce intracellular changes.
Tue Mar 02 00:00:00 UTC 2021
Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila.
eLife
Elliott AD,Berndt A,Houpert M,Roy S,Scott RL,Chow CC,Shroff H,White BH
A-11122 was used in Immunohistochemistry to provide a platform for studying whole-animal behavior, quantifying its variability across multiple spatiotemporal scales, and analyzing its neuromodulatory regulation at cellular resolution.
Thu Jul 08 00:00:00 UTC 2021
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension.
Nature communications
McCray BA,Diehl E,Sullivan JM,Aisenberg WH,Zaccor NW,Lau AR,Rich DJ,Goretzki B,Hellmich UA,Lloyd TE,Sumner CJ
A-11122 was used in Western Blot to identify RhoA as a critical mediator of TRPV4-induced cell structure changes and suggest that disruption of TRPV4-RhoA binding may contribute to tissue-specific toxicity of TRPV4 neuropathy mutations.
Thu Mar 04 00:00:00 UTC 2021
Neural control of affiliative touch in prosocial interaction.
Nature
Wu YE,Dang J,Kingsbury L,Zhang M,Sun F,Hu RK,Hong W
A-11122 was used in Multiplexed Error-Robust Fluorescence in situ Hybridization to demonstrate that mice display prosocial comforting behaviour and reveals a neural circuit mechanism that underlies the encoding and control of affiliative touch during prosocial interactions.
Mon Nov 01 00:00:00 UTC 2021
Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration.
Science advances
Kwak YD,Shaw TI,Downing SM,Tewari A,Jin H,Li Y,Dumitrache LC,Katyal S,Khodakhah K,Russell HR,McKinnon PJ
A-11122 was used in Western Blotting to reveal the pathogenic basis of DNA damage in the nervous system and suggest chromatin conformation as a feature in directing genome instability-associated neuropathology.
Fri Dec 17 00:00:00 UTC 2021
The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis.
Journal of integrative plant biology
Guo J,Wei L,Chen SS,Cai XW,Su YN,Li L,Chen S,He XJ
A-11122 was used in Immunohistochemistry-immunofluorescence to identify all of the components of Arabidopsis MEDIATOR and reveal the mechanism underlying the link between histone acetylation and transcriptional regulation.
Thu Apr 01 00:00:00 UTC 2021
Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila.
Nature communications
Botero V,Stanhope BA,Brown EB,Grenci EC,Boto T,Park SJ,King LB,Murphy KR,Colodner KJ,Walker JA,Keene AC,Ja WW,Tomchik SM
A-11122 was used in Western Blot to indicate that neurofibromin regulates metabolic rate via neuronal mechanisms, suggest that cellular and systemic metabolic alterations may represent a pathophysiological mechanism in neurofibromatosis type 1, and provide a platform for investigating the cellular role of neurofibromin in metabolic homeostasis.
Tue Jul 13 00:00:00 UTC 2021
Molecular and cellular basis of acid taste sensation in Drosophila.
Nature communications
Mi T,Mack JO,Lee CM,Zhang YV
A-11122 was used in Immunocytochemistry to investigate how animals discriminate low from high acidity foods.
Thu Jun 17 00:00:00 UTC 2021
The endocycle restores tissue tension in the Drosophila abdomen post wound repair.
Cell reports
Losick VP,Duhaime LG
A-11122 was used in Immunohistochemistry to find that the wound-induced polyploid cells remodel the epithelium to maintain fly abdominal movements, which may help compensate for lost tissue tension.
Tue Oct 12 00:00:00 UTC 2021
Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin.
Science advances
Cheah PS,Prabhakar S,Yellen D,Beauchamp RL,Zhang X,Kasamatsu S,Bronson RT,Thiele EA,Kwiatkowski DJ,Stemmer-Rachamimov A,György B,Ling KH,Kaneki M,Tannous BA,Ramesh V,Maguire CA,Breakefield XO
A-11122 was used in Immunocytochemistry-immunofluorescence to demonstrate the potential of treating life-threatening TSC2 lesions with a single intravenous injection of AAV9-cTuberin.
Fri Jan 01 00:00:00 UTC 2021
Differential requirement of MED14/17 recruitment for activation of heat inducible genes.
The New phytologist
Ohama N,Moo TL,Chua NH
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to highlight the importance of differential recruitment of Mediator for the precise control of HS responses in plants.
Mon Mar 01 00:00:00 UTC 2021
A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus.
Cell reports
Uemura M,Blankvoort S,Tok SSL,Yuan L,Cobar LF,Lit KK,Tashiro A
A-11122 was used in Immunohistochemistry to suggest that the behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis.
Tue Jul 06 00:00:00 UTC 2021
Two metallothionein genes highly expressed in rice nodes are involved in distribution of Zn to the grain.
The New phytologist
Lei GJ,Yamaji N,Ma JF
A-11122 was used in Cell Culture to suggest that both OsMT2b and OsMT2c play an important role mainly in the distribution of Zn to grain through chelation and subsequent transport of Zn in the phloem in rice.
Fri Jan 01 00:00:00 UTC 2021
Patterns of differentiation of renin lineage cells during nephrogenesis.
American journal of physiology. Renal physiology
Kessel F,Steglich A,Hickmann L,Lira Martinez R,Gerlach M,Sequeira-Lopez MLS,Gomez RA,Hugo CPM,Todorov VT
A-11122 was used in Immunohistochemistry-immunofluorescence to quantify different renal vascular and tubular cell types based on specific markers and assessed proliferation and de novo differentiation in the RLC population.
Wed Sep 01 00:00:00 UTC 2021
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Nature
Yu K,Lin CJ,Hatcher A,Lozzi B,Kong K,Huang-Hobbs E,Cheng YT,Beechar VB,Zhu W,Zhang Y,Chen F,Mills GB,Mohila CA,Creighton CJ,Noebels JL,Scott KL,Deneen B
A-11122 was used in Immunohistochemistry to develop a high-throughput in vivo screening platform and discover several driver variants of PIK3CA, using a native mouse model of glioblastoma.
Sat Feb 01 00:00:00 UTC 2020
Epigenetic gene silencing by heterochromatin primes fungal resistance.
Nature
Torres-Garcia S,Yaseen I,Shukla M,Audergon PNCB,White SA,Pidoux AL,Allshire RC
A-11122 was used in Chromatin immunoprecipitation to reveal that epigenetic processes promote phenotypic plasticity, letting wild-type cells adapt to unfavourable environments without genetic alteration.
Tue Sep 01 00:00:00 UTC 2020
Parallel ascending spinal pathways for affective touch and pain.
Nature
Choi S,Hachisuka J,Brett MA,Magee AR,Omori Y,Iqbal NU,Zhang D,DeLisle MM,Wolfson RL,Bai L,Santiago C,Gong S,Goulding M,Heintz N,Koerber HR,Ross SE,Ginty DD
A-11122 was used in Immunohistochemistry to show that two populations of projection neurons that express the structurally related G-protein-coupled receptors (GPCRs) TACR1 and GPR83 form parallel ascending circuit modules that cooperate to convey thermal, tactile and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the pons.
Sun Nov 01 00:00:00 UTC 2020
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Cell
Yu CH,Davidson S,Harapas CR,Hilton JB,Mlodzianoski MJ,Laohamonthonkul P,Louis C,Low RRJ,Moecking J,De Nardo D,Balka KR,Calleja DJ,Moghaddas F,Ni E,McLean CA,Samson AL,Tyebji S,Tonkin CJ,Bye CR,Turner BJ,Pepin G,Gantier MP,Rogers KL,McArthur K,Crouch PJ,Masters SL
A-11122 was used in Immunocytochemistry-immunoflourescence to show that amyotrophic lateral sclerosis (ALS), associated neuroinflammatory cytokine profile is driven by the cytoplasmic DNA sensor cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) when TDP-43 invades mitochondria and releases DNA via the permeability transition pore.
Thu Oct 29 00:00:00 UTC 2020
Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging.
Nature methods
Zhang Y,Schroeder LK,Lessard MD,Kidd P,Chung J,Song Y,Benedetti L,Li Y,Ries J,Grimm JB,Lavis LD,De Camilli P,Rothman JE,Baddeley D,Bewersdorf J
A-11122 was used in Western Blot to resolve the highly convoluted Golgi apparatus and the close contacts between the endoplasmic reticulum and the plasma membrane with three-dimensional fluorescence images.
Sat Feb 01 00:00:00 UTC 2020
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Cancer cell
Coles GL,Cristea S,Webber JT,Levin RS,Moss SM,He A,Sangodkar J,Hwang YC,Arand J,Drainas AP,Mooney NA,Demeter J,Spradlin JN,Mauch B,Le V,Shue YT,Ko JH,Lee MC,Kong C,Nomura DK,Ohlmeyer M,Swaney DL,Krogan NJ,Jackson PK,Narla G,Gordan JD,Shokat KM,Sage J
A-11122 was used in Western Blot to identify protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC).
Mon Jul 13 00:00:00 UTC 2020
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer.
Cancer discovery
Costa C,Wang Y,Ly A,Hosono Y,Murchie E,Walmsley CS,Huynh T,Healy C,Peterson R,Yanase S,Jakubik CT,Henderson LE,Damon LJ,Timonina D,Sanidas I,Pinto CJ,Mino-Kenudson M,Stone JR,Dyson NJ,Ellisen LW,Bardia A,Ebi H,Benes CH,Engelman JA,Juric D
A-11122 was used in Immunocytochemistry to reveal that some resistant tumors acquired RB loss, whereas other tumors lost PTEN expression at the time of progression.
Wed Jan 01 00:00:00 UTC 2020
Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes.
Gastroenterology
Liu P,Liang B,Liu M,Lebbink JHG,Li S,Qian M,Lavrijsen M,Peppelenbosch MP,Chen X,Smits R
A-11122 was used in Western Blotting to investigate the mechanisms by which these substitutions increase signaling and the effects on liver carcinogenesis in mice.
Sun Mar 01 00:00:00 UTC 2020
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.
Cell metabolism
Mukherjee C,Kling T,Russo B,Miebach K,Kess E,Schifferer M,Pedro LD,Weikert U,Fard MK,Kannaiyan N,Rossner M,Aicher ML,Goebbels S,Nave KA,Krämer-Albers EM,Schneider A,Simons M
A-11122 was used in Western Blot to identify glial molecules providing vital functions to neurons.
Tue Aug 04 00:00:00 UTC 2020
Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs.
Nature neuroscience
Soden ME,Chung AS,Cuevas B,Resnick JM,Awatramani R,Zweifel LS
A-11122 was used in Immunohistochemistry to map the major neurotransmitter projections to the ventral tegmental area through cell-type-specific retrograde and anterograde tracing.
Sat Aug 01 00:00:00 UTC 2020
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior.
Nature neuroscience
Barsy B,Kocsis K,Magyar A,Babiczky Á,Szabó M,Veres JM,Hillier D,Ulbert I,Yizhar O,Mátyás F
A-11122 was used in Immunohistochemistry to demonstrate that Calr+LT neurons provide integrated CS-US representations to the LA that support the formation of aversive memories.
Fri May 01 00:00:00 UTC 2020
Posterior amygdala regulates sexual and aggressive behaviors in male mice.
Nature neuroscience
Yamaguchi T,Wei D,Song SC,Lim B,Tritsch NX,Lin D
A-11122 was used in Immunohistochemistry-immunofluorescence to identify estrogen receptor alpha (Esr1)-expressing cells in the posterior amygdala (PA) as a main source of excitatory inputs to the hypothalamus and key mediators for mating and fighting in male mice.
Tue Sep 01 00:00:00 UTC 2020
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Nature cell biology
Zhang R,Lee DM,Jimah JR,Gerassimov N,Yang C,Kim S,Luvsanjav D,Winkelman J,Mettlen M,Abrams ME,Kalia R,Keene P,Pandey P,Ravaux B,Kim JH,Ditlev JA,Zhang G,Rosen MK,Frost A,Alto NM,Gardel M,Schmid SL,Svitkina TM,Hinshaw JE,Chen EH
A-11122 was used in Immunocytochemistry to reveal a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo.
Mon Jun 01 00:00:00 UTC 2020
Context-Dependent Gene Regulation by Homeodomain Transcription Factor Complexes Revealed by Shape-Readout Deficient Proteins.
Molecular cell
Kribelbauer JF,Loker RE,Feng S,Rastogi C,Abe N,Rube HT,Bussemaker HJ,Mann RS
A-11122 was used in Immunohistochemistry to demonstrate that high-throughput in vitro DNA binding assays coupled with unbiased computational analysis provide unprecedented insight into how different DNA sequences select distinct compositions and configurations of homeodomain TF complexes.
Thu Apr 02 00:00:00 UTC 2020
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.
Molecular cell
Wigington CP,Roy J,Damle NP,Yadav VK,Blikstad C,Resch E,Wong CJ,Mackay DR,Wang JT,Krystkowiak I,Bradburn DA,Tsekitsidou E,Hong SH,Kaderali MA,Xu SL,Stearns T,Gingras AC,Ullman KS,Ivarsson Y,Davey NE,Cyert MS
A-11122 was used in Immunocytochemistry to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca2+-activated phosphatase that recognizes LxVP and PxIxIT motifs.
Thu Jul 16 00:00:00 UTC 2020
Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species.
Nucleic acids research
He X,Chen W,Liu Z,Yu G,Chen Y,Cai YJ,Sun L,Xu W,Zhong L,Gao C,Chen J,Zhang M,Yang S,Yao Y,Zhang Z,Ma F,Zhang CC,Lu HP,Yu B,Cheng TL,Qiu J,Sheng Q,Zhou HM,Lv ZR,Yan J,Zhou Y,Qiu Z,Cui Z,Zhang X,Meng A,Sun Q,Yang Y
A-11122 was used in Immunohistochemistry-immunofluorescence to develop an efficient and low-risk gene editing method.
Thu Jun 04 00:00:00 UTC 2020
Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.
Nucleic acids research
Wedel M,Fröb F,Elsesser O,Wittmann MT,Lie DC,Reis A,Wegner M
A-11122 was used in Immunocytochemistry to point to the possibility of an oligodendroglial contribution to these disorders.
Thu May 21 00:00:00 UTC 2020
The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition.
Nucleic acids research
Furukawa T,Scheven MT,Misslinger M,Zhao C,Hoefgen S,Gsaller F,Lau J,Jöchl C,Donaldson I,Valiante V,Brakhage AA,Bromley MJ,Haas H,Hortschansky P
A-11122 was used in Chromatin immunoprecipitation to show that CBC:HapX interaction is absolutely required for all known functions of HapX.
Fri Apr 17 00:00:00 UTC 2020
The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.
Nucleic acids research
Kenny PJ,Kim M,Skariah G,Nielsen J,Lannom MC,Ceman S
A-11122 was used in Western Blot to characterize the FMRP-containing mRNP that regulates translation of bound mRNAs at the molecular level.
Fri Jan 24 00:00:00 UTC 2020
Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement.
Neuron
Heymann G,Jo YS,Reichard KL,McFarland N,Chavkin C,Palmiter RD,Soden ME,Zweifel LS
A-11122 was used in Immunohistochemistry to identify functionally distinct dopaminergic neurons in the ventral tegmental area involved in motivation and reward.
Wed Mar 04 00:00:00 UTC 2020
LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.
Neuron
Sinha R,Siddiqui TJ,Padmanabhan N,Wallin J,Zhang C,Karimi B,Rieke F,Craig AM,Wong RO,Hoon M
A-11122 was used in Western Blotting to find that LRRTM4 is enriched at GABAergic synapses on axon terminals of rod bipolar cells (RBCs).
Wed Mar 18 00:00:00 UTC 2020
Encoding of 3D Head Orienting Movements in the Primary Visual Cortex.
Neuron
Guitchounts G,Masís J,Wolff SBE,Cox D
A-11122 was used in Immunohistochemistry-immunofluorescence to show that 3D head-orienting movements (HOMs) modulate primary visual cortex (V1) activity in a direction-specific manner that also depends on light.
Wed Nov 11 00:00:00 UTC 2020
CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State.
Neuron
Thornquist SC,Langer K,Zhang SX,Rogulja D,Crickmore MA
A-11122 was used in Immunohistochemistry-immunofluorescence to discover whether the activation and gradual relaxation of calcium-independent CaMKII measure a 6-min time window to coordinate two male-specific events during Drosophila mating: sperm transfer and a simultaneous decrease in motivation.
Wed Jan 22 00:00:00 UTC 2020
Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila.
Neuron
Jung Y,Kennedy A,Chiu H,Mohammad F,Claridge-Chang A,Anderson DJ
A-11122 was used in Immunohistochemistry to identify pCd neurons as persistently active, indirect P1 targets that are required for P1-evoked persistent courtship and aggression.
Wed Jan 22 00:00:00 UTC 2020
Selective Mesoaccumbal Pathway Inactivation Affects Motivation but Not Reinforcement-Based Learning in Macaques.
Neuron
Vancraeyenest P,Arsenault JT,Li X,Zhu Q,Kobayashi K,Isa K,Isa T,Vanduffel W
A-11122 was used in Immunohistochemistry to demonstrate that selective, unidirectional, and reversible blockage of the primarily dopaminergic mesoaccumbal circuit in monkeys increased network-level functional connectivity, especially in fronto-temporal cortex.
Wed Nov 11 00:00:00 UTC 2020
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses.
The Journal of experimental medicine
Low JS,Farsakoglu Y,Amezcua Vesely MC,Sefik E,Kelly JB,Harman CCD,Jackson R,Shyer JA,Jiang X,Cauley LS,Flavell RA,Kaech SM
A-11122 was used in Immunocytochemistry to demonstrate that lung CD8+ TRM cells are reactivated more quickly, yet less efficiently, than their counterparts in the draining LNs (TLN cells).
Mon Aug 03 00:00:00 UTC 2020
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
The Journal of experimental medicine
Lehmann GL,Hanke-Gogokhia C,Hu Y,Bareja R,Salfati Z,Ginsberg M,Nolan DJ,Mendez-Huergo SP,Dalotto-Moreno T,Wojcinski A,Ochoa F,Zeng S,Cerliani JP,Panagis L,Zager PJ,Mullins RF,Ogura S,Lutty GA,Bang J,Zippin JH,Romano C,Rabinovich GA,Elemento O,Joyner AL,Rafii S,Rodriguez-Boulan E,Benedicto I
A-11122 was used in Immunocytochemistry to open new avenues for the study and treatment of retinal vascular diseases and choroid-related inflammatory blinding disorders.
Mon Jun 01 00:00:00 UTC 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
A-11122 was used in Immunocytochemistry to demonstrate that colonic macrophage-intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages.
Mon Apr 06 00:00:00 UTC 2020
Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy.
Brain : a journal of neurology
Yoon SY,Hunter JE,Chawla S,Clarke DL,Molony C,O'Donnell PA,Bagel JH,Kumar M,Poptani H,Vite CH,Wolfe JH
A-11122 was used in Immunohistochemistry to study the potential for therapeutic application of the hu.32 serotype in a gyrencephalic brain of larger mammals.
Wed Jul 01 00:00:00 UTC 2020
ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.
Brain : a journal of neurology
Kannan A,Jiang X,He L,Ahmad S,Gangwani L
A-11122 was used in Western Blot to conclude that ZPR1 represents a protective modifier and a therapeutic target for developing a new method for the treatment of SMA.
Wed Jan 01 00:00:00 UTC 2020
Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability.
The EMBO journal
Zhang M,Liang C,Chen Q,Yan H,Xu J,Zhao H,Yuan X,Liu J,Lin S,Lu W,Wang F
A-11122 was used in Immunocytochemistry to reveal a fundamental role for histone phosphorylation in resolving centromere DNA entanglements and safeguarding genomic stability during mitosis.
Mon Feb 03 00:00:00 UTC 2020
Structural basis of semaphorin-plexin cis interaction.
The EMBO journal
Rozbesky D,Verhagen MG,Karia D,Nagy GN,Alvarez L,Robinson RA,Harlos K,Padilla-Parra S,Pasterkamp RJ,Jones EY
A-11122 was used in Immunocytochemistry to study the structural interaction and dynamics between the semaphorin-plexin cis interaction.
Wed Jul 01 00:00:00 UTC 2020
Distinct retrograde microtubule motor sets drive early and late endosome transport.
The EMBO journal
Villari G,Enrico Bena C,Del Giudice M,Gioelli N,Sandri C,Camillo C,Fiorio Pla A,Bosia C,Serini G
A-11122 was used in Western Blot, Immunoprecipitation to provide evidence that distinct minus end-directed MT motor systems drive the differential transport and subcellular distribution of EEs and LEs in mammalian cells.
Tue Dec 15 00:00:00 UTC 2020
Distinct retrograde microtubule motor sets drive early and late endosome transport.
The EMBO journal
Villari G,Enrico Bena C,Del Giudice M,Gioelli N,Sandri C,Camillo C,Fiorio Pla A,Bosia C,Serini G
A-11122 was used in Western Blot, Immunoprecipitation to provide evidence that distinct minus end-directed MT motor systems drive the differential transport and subcellular distribution of EEs and LEs in mammalian cells.
Tue Dec 15 00:00:00 UTC 2020
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
The EMBO journal
Moissoglu K,Stueland M,Gasparski AN,Wang T,Jenkins LM,Hastings ML,Mili S
A-11122 was used in Western Blot, Proximity Ligation Assay (PLA) to investigate the functional role of RNA localization at cellular protrusions of migrating mesenchymal cells, using as a model the RAB13 RNA, which encodes a GTPase important for vesicle-mediated membrane trafficking.
Mon Nov 02 00:00:00 UTC 2020
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
The EMBO journal
Moissoglu K,Stueland M,Gasparski AN,Wang T,Jenkins LM,Hastings ML,Mili S
A-11122 was used in Western Blot, Proximity Ligation Assay (PLA) to investigate the functional role of RNA localization at cellular protrusions of migrating mesenchymal cells, using as a model the RAB13 RNA, which encodes a GTPase important for vesicle-mediated membrane trafficking.
Mon Nov 02 00:00:00 UTC 2020
A microtubule polymerase is required for microtubule orientation and dendrite pruning in Drosophila.
The EMBO journal
Tang Q,Rui M,Bu S,Wang Y,Chew LY,Yu F
A-11122 was used in Western Blotting to demonstrate that the MT polymerase Msps is required to form dendritic minus-end-out MTs and thereby promotes dendrite pruning in Drosophila sensory neurons.
Mon May 18 00:00:00 UTC 2020
Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles.
The EMBO journal
Ryan TA,Phillips EO,Collier CL,Jb Robinson A,Routledge D,Wood RE,Assar EA,Tumbarello DA
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubiquitin ligase Parkin.
Tue Jun 02 00:00:00 UTC 2020
Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles.
The EMBO journal
Ryan TA,Phillips EO,Collier CL,Jb Robinson A,Routledge D,Wood RE,Assar EA,Tumbarello DA
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubiquitin ligase Parkin.
Tue Jun 02 00:00:00 UTC 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
The EMBO journal
Weinert S,Gimber N,Deuschel D,Stuhlmann T,Puchkov D,Farsi Z,Ludwig CF,Novarino G,López-Cayuqueo KI,Planells-Cases R,Jentsch TJ
A-11122 was used in Immunohistochemistry to generate Clcn3unc/unc mice in which ClC-3 is converted into a Cl- channel.
Mon May 04 00:00:00 UTC 2020
Glycolysis regulates Hedgehog signalling via the plasma membrane potential.
The EMBO journal
Spannl S,Buhl T,Nellas I,Zeidan SA,Iyer KV,Khaliullina H,Schultz C,Nadler A,Dye NA,Eaton S
A-11122 was used in Immunocytochemistry-Immunofluorescence to show that reducing glycolysis both lowers steady-state levels of ATP and stabilizes Smoothened (Smo), the 7-pass transmembrane protein that transduces the Hh signal.
Mon Nov 02 00:00:00 UTC 2020
Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.
Developmental cell
Lu Y,Shiau F,Yi W,Lu S,Wu Q,Pearson JD,Kallman A,Zhong S,Hoang T,Zuo Z,Zhao F,Zhang M,Tsai N,Zhuo Y,He S,Zhang J,Stein-O'Brien GL,Sherman TD,Duan X,Fertig EJ,Goff LA,Zack DJ,Handa JT,Xue T,Bremner R,Blackshaw S,Wang X,Clark BS
A-11122 was used in Immunohistochemistry to provide a roadmap to future studies of human retinal development and may help guide the design of cell-based therapies for treating retinal dystrophies.
Mon May 18 00:00:00 UTC 2020
AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.
Developmental cell
Marneros AG
A-11122 was used in Immunohistochemistry to show that the transcription factor AP-2β is required for the differentiation of distal tubule precursors into early stage distal convoluted tubules during nephrogenesis.
Mon Aug 10 00:00:00 UTC 2020
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Autophagy
Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z
A-11122 was used in Immunocytochemistry-immunoflourescence to show that amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)-linked mutations of TBK1 and SQSTM1 disrupt selective autophagy and cause neurotoxicity.
Fri May 01 00:00:00 UTC 2020
Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes.
Autophagy
Zhang Z,Yan J,Bowman AB,Bryan MR,Singh R,Aschner M
A-11122 was used in Western Blotting to indicate that the dysregulation of TFEB (transcription factor EB) is involved in manganese-induced autotrophic failure.
Sat Aug 01 00:00:00 UTC 2020
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence.
Proceedings of the National Academy of Sciences of the United States of America
Werner CT,Mitra S,Auerbach BD,Wang ZJ,Martin JA,Stewart AF,Gobira PH,Iida M,An C,Cobb MM,Caccamise A,Salvi RJ,Neve RL,Gancarz AM,Dietz DM
A-11122 was used in Immunocytochemistry to demonstrate a role for the DH in relapse behavior following prolonged abstinence from cocaine self-administration.
Tue Oct 20 00:00:00 UTC 2020
Functionally distinct Purkinje cell types show temporal precision in encoding locomotion.
Proceedings of the National Academy of Sciences of the United States of America
Chang W,Pedroni A,Hohendorf V,Giacomello S,Hibi M,Köster RW,Ampatzis K
A-11122 was used in Immunohistochemistry to show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types.
Tue Jul 21 00:00:00 UTC 2020
Dimer interaction in the Hv1 proton channel.
Proceedings of the National Academy of Sciences of the United States of America
Mony L,Stroebel D,Isacoff EY
A-11122 was used in Western Blotting to investigate the gating mechanisms and the importance of dimer interactions within the gating of the Hv1 channel.
Tue Aug 25 00:00:00 UTC 2020
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Han JS,Hino K,Li W,Reyes RV,Canales CP,Miltner AM,Haddadi Y,Sun J,Chen CY,La Torre A,Simó S
A-11122 was used in Immunohistochemistry to investigate CRL5 as a key regulator of hippocampal development and uncovered ARL4C, CYTH1, and ARF6 as CRL5-regulated signaling effectors that control pyramidal neuron migration and dendritogenesis.
Tue Sep 15 00:00:00 UTC 2020
Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.
Proceedings of the National Academy of Sciences of the United States of America
Su J,Charalambakis NE,Sabbagh U,Somaiya RD,Monavarfeshani A,Guido W,Fox MA
A-11122 was used in Immunohistochemistry to show that retinal inputs signal through astrocytes to direct the long-range recruitment of interneurons into the visual thalamus.
Tue Feb 04 00:00:00 UTC 2020
Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling.
Proceedings of the National Academy of Sciences of the United States of America
Zhang L,Jing H,Li H,Chen W,Luo B,Zhang H,Dong Z,Li L,Su H,Xiong WC,Mei L
A-11122 was used in Immunohistochemistry to provide evidence for an indispensable role of neddylation, a ubiquitylation-like protein modification, in inhibiting Wnt/β-catenin signaling.
Tue Oct 20 00:00:00 UTC 2020
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.
Proceedings of the National Academy of Sciences of the United States of America
Campbell BC,Nabel EM,Murdock MH,Lao-Peregrin C,Tsoulfas P,Blackmore MG,Lee FS,Liston C,Morishita H,Petsko GA
A-11122 was used in Immunocytochemistry to test hypothesis that EGFP's low solubility in mammalian systems must limit the total fluorescence output of whole cells, and that improving folding efficiency could therefore translate into greater brightness of expressing neurons.
Tue Dec 01 00:00:00 UTC 2020
The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1.
Proceedings of the National Academy of Sciences of the United States of America
Hamaoui D,Cossé MM,Mohan J,Lystad AH,Wollert T,Subtil A
A-11122 was used in Immunoprecipitation to show that the host autophagy-related protein 16-1 (ATG16L1) restricts inclusion growth and that this effect is counteracted by the secretion of the bacterial effector CT622/TaiP (translocated ATG16L1 interacting protein).
Tue Oct 27 00:00:00 UTC 2020
CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
The Plant cell
Kimura S,Hunter K,Vaahtera L,Tran HC,Citterico M,Vaattovaara A,Rokka A,Stolze SC,Harzen A,Meißner L,Wilkens MMT,Hamann T,Toyota M,Nakagami H,Wrzaczek M
A-11122 was used in Immunoprecipitation to determine that reactive oxygen species production in Arabidopsis is regulated by CRK2 and the phosphorylation of the C-terminal region of NADPH oxidase.
Wed Apr 01 00:00:00 UTC 2020
Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons.
Cell death and differentiation
Tang FL,Zhao L,Zhao Y,Sun D,Zhu XJ,Mei L,Xiong WC
A-11122 was used in Immunohistochemistry to provide evidence that Vps35 in embryonic neurons is necessary for axonal and dendritic terminal differentiation.
Wed Jul 01 00:00:00 UTC 2020
NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism.
American journal of human genetics
Guo H,Zhang Q,Dai R,Yu B,Hoekzema K,Tan J,Tan S,Jia X,Chung WK,Hernan R,Alkuraya FS,Alsulaiman A,Al-Muhaizea MA,Lesca G,Pons L,Labalme A,Laux L,Bryant E,Brown NJ,Savva E,Ayres S,Eratne D,Peeters H,Bilan F,Letienne-Cejudo L,Gilbert-Dussardier B,Ruiz-Arana IL,Merlini JM,Boizot A,Bartoloni L,Santoni F,Karlowicz D,McDonald M,Wu H,Hu Z,Chen G,Ou J,Brasch-Andersen C,Fagerberg CR,Dreyer I,Chun-Hui Tsai A,Slegesky V,McGee RB,Daniels B,Sellars EA,Carpenter LA,Schaefer B,Sacoto MJG,Begtrup A,Schnur RE,Punj S,Wentzensen IM,Rhodes L,Pan Q,Bernier RA,Chen C,Eichler EE,Xia K
A-11122 was used in Immunohistochemistry to show that NCKAP1 is broadly and highly expressed in both prenatal and postnatal periods and demostrate enriched expression in excitatory neurons and radial glias but depleted expression in inhibitory neurons.
Thu Nov 05 00:00:00 UTC 2020
Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis.
Current biology : CB
Khadilkar RJ,Ho KYL,Venkatesh B,Tanentzapf G
A-11122 was used in Immunohistochemistry to provide mechanistic insight into how integrins can shape the signaling environment around hematopoietic progenitors.
Mon Sep 07 00:00:00 UTC 2020
Parallel Mechanosensory Pathways Direct Oviposition Decision-Making in Drosophila.
Current biology : CB
Zhang L,Yu J,Guo X,Wei J,Liu T,Zhang W
A-11122 was used in Immunohistochemistry to uncover drosophila mechanisms of detection of substrate quality for oviposition.
Mon Aug 17 00:00:00 UTC 2020
Ovipositor Extrusion Promotes the Transition from Courtship to Copulation and Signals Female Acceptance in Drosophila melanogaster.
Current biology : CB
Mezzera C,Brotas M,Gaspar M,Pavlou HJ,Goodwin SF,Vasconcelos ML
A-11122 was used in Immunohistochemistry to demonstrate the role of oviposter extrusion during Drosophila melanogaster copulation.
Mon Oct 05 00:00:00 UTC 2020
A Feedforward Circuit Regulates Action Selection of Pre-mating Courtship Behavior in Female Drosophila.
Current biology : CB
Ishimoto H,Kamikouchi A
A-11122 was used in Immunohistochemistry to elucidate the molecular and neural mechanisms regulating the behavioral selection process of the pre-mating female.
Mon Feb 03 00:00:00 UTC 2020
Interclass GPCR heteromerization affects localization and trafficking.
Science signaling
Toneatti R,Shin JM,Shah UH,Mayer CR,Saunders JM,Fribourg M,Arsenovic PT,Janssen WG,Sealfon SC,López-Giménez JF,Benson DL,Conway DE,González-Maeso J
A-11122 was used in Immunocytochemistry-immunoflourescence to show that the class A serotonin 5-HT2A receptors (5-HT2ARs) affected the localization and trafficking of class C metabotropic glutamate receptor 2 (mGluR2) through a mechanism that required their assembly as heteromers in mammalian cells.
Tue Oct 20 00:00:00 UTC 2020
Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation.
The Journal of cell biology
Liang C,Zhang Z,Chen Q,Yan H,Zhang M,Zhou L,Xu J,Lu W,Wang F
A-11122 was used in Western Blotting to provide insights into how centromeric Aurora B regulates SAC and kinetochore attachment to microtubules to ensure error-free chromosome segragation.
Mon Feb 03 00:00:00 UTC 2020
A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance.
The Journal of cell biology
Boyer NP,McCormick LE,Menon S,Urbina FL,Gupton SL
A-11122 was used in Western Blotting to show that the TRIM9-related protein TRIM67 outcompetes TRIM9 for interacting with VASP and antagonizes TRIM9-dependent VASP ubiquitination.
Mon Jan 06 00:00:00 UTC 2020
centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.
The Journal of cell biology
Ryder PV,Fang J,Lerit DA
A-11122 was used in Immunoprecipitation to investigate the regulation of mRNA localization to centrosomes in the rapidly cycling Drosophila melanogaster embryo.
Mon Dec 07 00:00:00 UTC 2020
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
Acta physiologica (Oxford, England)
Solagna F,Nogara L,Dyar KA,Greulich F,Mir AA,Türk C,Bock T,Geremia A,Baraldo M,Sartori R,Farup J,Uhlenhaut H,Vissing K,Krüger M,Blaauw B
A-11122 was used in Western Blotting to identify new signalling pathways important for muscle remodelling after exercise.
Tue Sep 01 00:00:00 UTC 2020
Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Jiang L,Mu H,Xu F,Xie D,Su W,Xu J,Sun Z,Liu S,Luo J,Shi Y,Leak RK,Wechsler LR,Chen J,Hu X
A-11122 was used in Immunohistochemistry to provide a new resource to understand the mechanisms underlying microglial alterations in the aged brain milieu and sheds light on new strategies to improve microglial functions in aged stroke victims.
Tue Dec 01 00:00:00 UTC 2020
Genetic developmental timing revealed by inter-species transplantations in fish.
Development (Cambridge, England)
Fuhrmann JF,Buono L,Adelmann L,Martinez-Morales JR,Centanin L
A-11122 was used in Immunohistochemistry to report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells - a module.
Mon Nov 23 00:00:00 UTC 2020
Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.
Development (Cambridge, England)
Sidhwani P,Leerberg DM,Boezio GLM,Capasso TL,Yang H,Chi NC,Roman BL,Stainier DYR,Yelon D
A-11122 was used in Immunohistochemistry to indicate that cardiac function modulates OFT morphogenesis by triggering endocardial cell accumulation that induces OFT lumen expansion and shapes OFT dimensions.
Wed Jun 17 00:00:00 UTC 2020
Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium.
Development (Cambridge, England)
Linnemannstöns K,Witte L,Karuna M P,Kittel JC,Danieli A,Müller D,Nitsch L,Honemann-Capito M,Grawe F,Wodarz A,Gross JC
A-11122 was used in Immunocytochemistry to investigate how Wnts are sorted at the level of endosomes by the versatile v-SNARE Ykt6.
Fri Aug 14 00:00:00 UTC 2020
Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration.
Development (Cambridge, England)
Thompson JD,Ou J,Lee N,Shin K,Cigliola V,Song L,Crawford GE,Kang J,Poss KD
A-11122 was used in Immunohistochemistry to identify candidate tissue regeneration enhancer elements (TREEs) important for zebrafish fin regeneration.
Thu Jul 30 00:00:00 UTC 2020
A genetic system for tissue-specific inhibition of cell proliferation.
Development (Cambridge, England)
Pu W,Han X,He L,Li Y,Huang X,Zhang M,Lv Z,Yu W,Wang QD,Cai D,Wang J,Sun R,Fei J,Ji Y,Nie Y,Zhou B
A-11122 was used in Immunohistochemistry to validate the use of ip21-GFP mice as a new genetic tool for cell lineage-specific inhibition of cell proliferation in vivo.
Mon Feb 17 00:00:00 UTC 2020
Different modes of Notch activation and strength regulation in the spermathecal secretory lineage.
Development (Cambridge, England)
Shen W,Sun J
A-11122 was used in Immunocytochemistry to show that the Drosophila spermathecal lineage is an exciting model for probing the molecular mechanisms that modulate the Notch signaling pathway.
Fri Feb 07 00:00:00 UTC 2020
AMP-activated protein kinase regulates cytoplasmic dynein behavior and contributes to neuronal migration in the developing neocortex.
Development (Cambridge, England)
Naito Y,Asada N,Nguyen MD,Sanada K
A-11122 was used in Western Blotting to conclude that AMPK-regulated dynein function via Ser81 DIC phosphorylation is crucial for radial neuronal migration.
Wed Jul 15 00:00:00 UTC 2020
An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.
Development (Cambridge, England)
Smolko AE,Shapiro-Kulnane L,Salz HK
A-11122 was used in Immunocytochemistry to reveal that ectopic PHF7 in female germ cells leads to a loss of sexual identity and the promotion of a regulatory circuit that is beneficial for tumor initiation and progression.
Fri Sep 11 00:00:00 UTC 2020
Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.
Development (Cambridge, England)
Ratzan EM,Moon AM,Deans MR
A-11122 was used in Immunohistochemistry to elucidate the role of FGF8 signaling in vestibular hair cell differentiation.
Thu Nov 19 00:00:00 UTC 2020
The kinesin motor Klp98A mediates apical to basal Wg transport.
Development (Cambridge, England)
Witte L,Linnemannstöns K,Schmidt K,Honemann-Capito M,Grawe F,Wodarz A,Gross JC
A-11122 was used in Immunocytochemistry to conclude that transcytosis-independent routes for Wg trafficking exist and demonstrate that Wg can be recycled apically via Rab4-recycling endosomes in the absence of Klp98A.
Fri Aug 14 00:00:00 UTC 2020
Cortical distribution of GABAergic interneurons is determined by migration time and brain size.
Development (Cambridge, England)
Fazzari P,Mortimer N,Yabut O,Vogt D,Pla R
A-11122 was used in Immunohistochemistry to suggest that the embryonic expansion of the cortex contributes to the rostrocaudal distribution of CINs.
Wed Jul 22 00:00:00 UTC 2020
Survival of Drosophila germline stem cells requires the chromatin-binding protein Barrier-to-autointegration factor.
Development (Cambridge, England)
Duan T,Kitzman SC,Geyer PK
A-11122 was used in Western Blotting to show that germ cell-specific BAF knockdown causes phenotypes that mirror emerin/otefin mutants.
Wed May 13 00:00:00 UTC 2020
Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.
Development (Cambridge, England)
Kellermeyer R,Heydman LM,Gillis T,Mastick GS,Song M,Kidd T
A-11122 was used in Immunohistochemistry to report that the BMP-1/Tolloid family metalloprotease Tolkin (Tok) is responsible for Slit proteolysis in vivo and in vitro.
Thu Oct 29 00:00:00 UTC 2020
The Drosophila NCAM homolog Fas2 signals independently of adhesion.
Development (Cambridge, England)
Neuert H,Deing P,Krukkert K,Naffin E,Steffes G,Risse B,Silies M,Klämbt C
A-11122 was used in Immunohistochemistry-immunofluorescence to study the function of single isoforms by conducting a comprehensive genetic analysis of F as2 We reveal the expression pattern of all major Fas2 isoforms, two of which are GPI anchored.
Wed Jan 22 00:00:00 UTC 2020
Environmental Light Is Required for Maintenance of Long-Term Memory in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inami S,Sato S,Kondo S,Tanimoto H,Kitamoto T,Sakai T
A-11122 was used in Immunohistochemistry to demonstrate that universally available environmental light plays a critical role in LTM maintenance by activating the evolutionarily conserved memory modulator CREB in MBs via the Pdf signaling pathway.
Wed Feb 12 00:00:00 UTC 2020
Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Su J,Basso D,Iyer S,Su K,Wei J,Fox MA
A-11122 was used in Immunohistochemistry to identify an extracellular matrix protein that is released by these early-born SST+ neurons to orchestrate inhibitory circuit formation in the developing cerebral cortex.
Wed Sep 23 00:00:00 UTC 2020
Accumulation of Neurofascin at Nodes of Ranvier Is Regulated by a Paranodal Switch.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang Y,Yuen S,Peles E,Salzer JL
A-11122 was used in Western Blotting to examine the role of paranodal junctions in the accumulation of NF186, a key adhesion molecule of PNS and CNS nodes.
Wed Jul 22 00:00:00 UTC 2020
Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Scapin C,Ferri C,Pettinato E,Bianchi F,Del Carro U,Feltri ML,Kaufman RJ,Wrabetz L,D'Antonio M
A-11122 was used in Western Blotting to provide genetic evidence that eIF2α phosphorylation has a protective role in Charcot-Marie-Tooth type 1B Schwann cells by limiting ERK/c-Jun hyperactivation.
Wed Oct 14 00:00:00 UTC 2020
The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Jean-Richard-Dit-Bressel P,Yau JO,Willing A,Prasad AA,Power JM,Killcross S,Clifford CWG,McNally GP
A-11122 was used in Immunohistochemistry to show how different forms of relapse to alcohol-seeking in male rats are assembled from activity across the VTA and the nucleus accumbens.
Wed Aug 12 00:00:00 UTC 2020
Nitric Oxide Signaling Strengthens Inhibitory Synapses of Cerebellar Molecular Layer Interneurons through a GABARAP-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Larson EA,Accardi MV,Wang Y,D'Antoni M,Karimi B,Siddiqui TJ,Bowie D
A-11122 was used in Immunoprecipitation to show that activation of NMDARs trigger a NO-dependent pathway that strengthens inhibitory GABAergic synapses of cerebellar molecular layer interneurons.
Wed Apr 22 00:00:00 UTC 2020
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Niu X,Liu L,Wang T,Chuan X,Yu Q,Du M,Gu Y,Wang L
A-11122 was used in Immunohistochemistry to provide basic anatomic information to explore the mechanisms underlying the process of assembling neural circuitry in the gut-brain axis (GBA).
Wed Aug 26 00:00:00 UTC 2020
Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yu HL,Peng Y,Zhao Y,Lan YS,Wang B,Zhao L,Sun D,Pan JX,Dong ZQ,Mei L,Ding YQ,Zhu XJ,Xiong WC
A-11122 was used in Immunoprecipitation to reveal Myo X-KIF13B as a critical pathway for Netrin-1-promoted axon initiation and branching/targeting.SIGNIFICANCE STATEMENT Netrin-1 increases Myosin X (Myo X) interaction with KIF13B, and thus promotes axonal delivery of Myo X and axon initiation and contralateral branching in developing cerebral neurons, revealing unrecognized functions and mechanisms underlying Netrin-1 regulation of axon development.
Wed Nov 25 00:00:00 UTC 2020
Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Schleyer M,Weiglein A,Thoener J,Strauch M,Hartenstein V,Kantar Weigelt M,Schuller S,Saumweber T,Eichler K,Rohwedder A,Merhof D,Zlatic M,Thum AS,Gerber B
A-11122 was used in Immunohistochemistry to investigate the neuronal circuitry that allows larval Drosophila melanogaster of either sex to negotiate this exploration-exploitation transition.
Wed Jul 29 00:00:00 UTC 2020
Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ravenscroft TA,Janssens J,Lee PT,Tepe B,Marcogliese PC,Makhzami S,Holmes TC,Aerts S,Bellen HJ
A-11122 was used in Western Blotting to determine the endogenous gene expression and subcellular localization of the sole NaV channel in both male and female Drosophila, para Despite being the only NaV channel in the fly, we show that only 23 1% of neurons in the embryonic and larval CNS express para, while in the adult CNS para is broadly expressed.
Wed Oct 14 00:00:00 UTC 2020
Dopamine Receptor Dop1R2 Stabilizes Appetitive Olfactory Memory through the Raf/MAPK Pathway in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sun H,Nishioka T,Hiramatsu S,Kondo S,Amano M,Kaibuchi K,Ichinose T,Tanimoto H
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the downstream intracellular molecular signaling underlying memory stabilization in Drosophila.
Wed Apr 01 00:00:00 UTC 2020
Identification and Characterization of the Heat-Induced Plastidial Stress Granules Reveal New Insight Into Arabidopsis Stress Response.
Frontiers in plant science
Chodasiewicz M,Sokolowska EM,Nelson-Dittrich AC,Masiuk A,Beltran JCM,Nelson ADL,Skirycz A
A-11122 was used in Affinity Purification to study the stress granule formation response in the model plant Arabidopsis thaliana.
Tue Nov 24 00:00:00 UTC 2020
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
Journal of virology
Deng X,Chen Y,Mielech AM,Hackbart M,Kesely KR,Mettelman RC,O'Brien A,Chapman ME,Mesecar AD,Baker SC
A-11122 was used in Western Blotting to identify amino acid substitutions within the ubiquitin-binding surface of PLP2 that reduced DUB activity.
Mon May 18 00:00:00 UTC 2020
Reverse Genetics Reveals a Role of Rotavirus VP3 Phosphodiesterase Activity in Inhibiting RNase L Signaling and Contributing to Intestinal Viral Replication In Vivo.
Journal of virology
Song Y,Feng N,Sanchez-Tacuba L,Yasukawa LL,Ren L,Silverman RH,Ding S,Greenberg HB
A-11122 was used in Western Blotting to show viral replication within the intestine can be enhanced by inhibition of RNase L signaling by rotavirus VP3 phosphodiesterase.
Thu Apr 16 00:00:00 UTC 2020
Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion.
Molecular cancer research : MCR
Chernichenko N,Omelchenko T,Deborde S,Bakst RL,He S,Chen CH,Gusain L,Vakiani E,Katabi N,Hall A,Wong RJ
A-11122 was used in Proximity Ligation Assay (PLA) to establish the GDNF-RET-β-Pix-Cdc42 pathway as a directional regulator of pancreatic cancer cell migration toward nerves, highlight the importance of directional migration in PNI, and offer novel targets for therapy.
Mon Jun 01 00:00:00 UTC 2020
SLC20A1 Is Involved in Urinary Tract and Urorectal Development.
Frontiers in cell and developmental biology
Rieke JM,Zhang R,Braun D,Yilmaz Ö,Japp AS,Lopes FM,Pleschka M,Hilger AC,Schneider S,Newman WG,Beaman GM,Nordenskjöld A,Ebert AK,Promm M,Rösch WH,Stein R,Hirsch K,Schäfer FM,Schmiedeke E,Boemers TM,Lacher M,Kluth D,Gosemann JH,Anderberg M,Barker G,Holmdahl G,Läckgren G,Keene D,Cervellione RM,Giorgio E,Di Grazia M,Feitz WFJ,Marcelis CLM,Van Rooij IALM,Bökenkamp A,Beckers GMA,Keegan CE,Sharma A,Dakal TC,Wittler L,Grote P,Zwink N,Jenetzky E,Brusco A,Thiele H,Ludwig M,Schweizer U,Woolf AS,Odermatt B,Reutter H
A-11122 was used in Immunohistochemistry to study the role of SLC20A1 in urinary tract development using a zebrafish model.
Wed Feb 14 00:00:00 UTC 2024
Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons.
Frontiers in cell and developmental biology
Gonzalez AE,Wang X
A-11122 was used in Immunohistochemistry to live image mitochondria and dense core vesicles in Drosophila third instar larval axons and perform genetic interaction experiments to study the role of valosin-containing protein in axon transport.
Mon Sep 28 00:00:00 UTC 2020
BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.
Frontiers in cell and developmental biology
Friesen EL,Zhang YT,Earnshaw R,De Snoo ML,O'Hara DM,Agapova V,Chau H,Ngana S,Chen KS,Kalia LV,Kalia SK
A-11122 was used in Western Blotting to identify a novel interaction between BAG5 and p62/sequestosome-1.
Mon Sep 28 00:00:00 UTC 2020
A Bird's Eye View on the Origin of Aortic Hemogenic Endothelial Cells.
Frontiers in cell and developmental biology
Seco P,Martins GG,Jacinto A,Tavares AT
A-11122 was used in Immunocytochemistry-immunoflourescence to discuss the current knowledge on the origin of aortic HECs with a particular focus on the evidence provided by studies in the avian embryo, a model that pioneered the field of developmental hematopoiesis.
Fri Dec 18 00:00:00 UTC 2020
Blockade of Glutathione Metabolism in IDH1-Mutated Glioma.
Molecular cancer therapeutics
Tang X,Fu X,Liu Y,Yu D,Cai SJ,Yang C
A-11122 was used in Western Blotting to investigate if isocitrate dehydrogenases 1 mutation results in the disruption of NADP+/NADPH balance and an increased demand for glutathione (GSH) metabolism.
Wed Jan 01 00:00:00 UTC 2020
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Palander O,Trimble WS
A-11122 was used in Western Blot to examine the role of DIAPH1 proteins in primary cilia maintenance.
Tue Dec 01 00:00:00 UTC 2020
Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lyons CE,Razzoli M,Larson E,Svedberg D,Frontini A,Cinti S,Vulchanova L,Sanders M,Thomas M,Bartolomucci A
A-11122 was used in Immunohistochemistry to demonstrate that local optogenetic stimulation of the sympathetic nerves is sufficient to elicit BAT and core thermogenesis, thus suggesting that peripheral neuromodulation has the potential to be exploited as an alternative to pharmacotherapies to elicit organ activation and thus ameliorate type 2 diabetes and/or obesity.
Sat Feb 01 00:00:00 UTC 2020
Myogenic Cell Expression of Intercellular Adhesion Molecule-1 Contributes to Muscle Regeneration after Injury.
The American journal of pathology
Martin RA,Buckley KH,Mankowski DC,Riley BM,Sidwell AN,Douglas SL,Worth RG,Pizza FX
A-11122 was used in Immunohistochemistry to investigate intercellular adhesion molecule-1 (ICAM-1), a membrane protein that mediates cell-to-cell adhesion and communication, as a mechanism through which the inflammatory response facilitates muscle regeneration after injury.
Thu Oct 01 00:00:00 UTC 2020
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.
Experimental neurology
Wang YC,Galeffi F,Wang W,Li X,Lu L,Sheng H,Hoffmann U,Turner DA,Yang W
A-11122 was used in Immunohistochemistry to demonstrate that acute inhibition of a subset of excitatory neurons after ischemic stroke can prevent brain injury and improve functional outcome.
Wed Apr 01 00:00:00 UTC 2020
Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.
Journal of immunology (Baltimore, Md. : 1950)
Ng TW,Wirchnianski AS,Wec AZ,Fels JM,Johndrow CT,Saunders KO,Liao HX,Chan J,Jacobs WR,Chandran K,Porcelli SA
A-11122 was used in Immunohistochemistry (Paraffin) to to investigate the potential for using CD4+ T cells arising in response to Bacille Calmette-Guérin as a source of help for driving antibody responses against viral vaccines.
Wed Jul 15 00:00:00 UTC 2020
Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.
Journal of immunology (Baltimore, Md. : 1950)
Ng TW,Wirchnianski AS,Wec AZ,Fels JM,Johndrow CT,Saunders KO,Liao HX,Chan J,Jacobs WR,Chandran K,Porcelli SA
A-11122 was used in Immunohistochemistry (Paraffin) to to investigate the potential for using CD4+ T cells arising in response to Bacille Calmette-Guérin as a source of help for driving antibody responses against viral vaccines.
Wed Jul 15 00:00:00 UTC 2020
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
Neuropharmacology
Harda Z,Spyrka J,Jastrzębska K,Szumiec Ł,Bryksa A,Klimczak M,Polaszek M,Gołda S,Zajdel J,Misiołek K,Błasiak A,Rodriguez Parkitna J
A-11122 was used in Immunohistochemistry to show that knocking down mu and delta receptors on dopamine receptor D1-expressing cells does not appreciably affect some of the reward-driven behaviors previously attributed to opioid signaling.
Tue Dec 01 00:00:00 UTC 2020
Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival.
Neuroscience bulletin
Gao C,Guo C,Peng Q,Cao J,Shohat-Ophir G,Liu D,Pan Y
A-11122 was used in Immunohistochemistry to understand the molecular underpinnings of how different organisms choose reproductive strategies and balance reproduction and survival.
Tue Dec 01 00:00:00 UTC 2020
Role of a versatile peptide motif controlling Hox nuclear export and autophagy in the Drosophila fat body.
Journal of cell science
Duffraisse M,Paul R,Carnesecchi J,Hudry B,Banreti A,Reboulet J,Ajuria L,Lohmann I,Merabet S
A-11122 was used in Immunohistochemistry to reveal the extreme molecular versatility of a unique short peptide motif for controlling the context-dependent activity of Hox proteins both at transcriptional and non-transcriptional levels.
Wed Sep 23 00:00:00 UTC 2020
OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion.
Journal of cell science
O'Loughlin T,Kruppa AJ,Ribeiro ALR,Edgar JR,Ghannam A,Smith AM,Buss F
A-11122 was used in Western Blotting to uncover a crucial role for OPTN in dampening NF-κB and IRF3 signalling through the sequestration of LUBAC and other positive regulators in this viral RNA-induced compartment, leading to altered pro-inflammatory cytokine secretion.
Mon Jun 15 00:00:00 UTC 2020
The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization.
Journal of cell science
Sen A,Hsieh WC,Hanna CB,Hsu CC,Pearson M,Tao WA,Aguilar RC
A-11122 was used in Western Blotting to indicate that the yeast Na+ pump Ena1 is an epsin (Ent1 and Ent2 in yeast)-specific cargo and that its internalization requires K1090, which likely undergoes Art3-dependent ubiquitylation.
Fri Aug 21 00:00:00 UTC 2020
Rabgap1 promotes recycling of active β1 integrins to support effective cell migration.
Journal of cell science
Samarelli AV,Ziegler T,Meves A,Fässler R,Böttcher RT
A-11122 was used in Western Blot, Immunocytochemistry to identify Rabgap1 as an important factor for conformation-specific integrin trafficking and define the role of Rabgap1 in β1-integrin-mediated cell migration in mouse fibroblasts and breast cancer cells.
Wed Sep 23 00:00:00 UTC 2020
Rabgap1 promotes recycling of active β1 integrins to support effective cell migration.
Journal of cell science
Samarelli AV,Ziegler T,Meves A,Fässler R,Böttcher RT
A-11122 was used in Western Blot, Immunocytochemistry to identify Rabgap1 as an important factor for conformation-specific integrin trafficking and define the role of Rabgap1 in β1-integrin-mediated cell migration in mouse fibroblasts and breast cancer cells.
Wed Sep 23 00:00:00 UTC 2020
Schizosaccharomyces pombe DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability.
Journal of cell science
Barg-Wojas A,Muraszko J,Kramarz K,Schirmeisen K,Baranowska G,Carr AM,Dziadkowiec D
A-11122 was used in ChIP assay to identify roles for Rrp1 and Rrp2 in maintaining centromere function by modulating histone dynamics, contributing to the preservation of genome stability during vegetative cell growth.
Mon Feb 10 00:00:00 UTC 2020
Canonical nucleators are dispensable for stress granule assembly in Drosophila intestinal progenitors.
Journal of cell science
Buddika K,Ariyapala IS,Hazuga MA,Riffert D,Sokol NS
A-11122 was used in Immunocytochemistry to report that the Drosophila orthologs of the mammalian SG components AGO1, ATX2, CAPRIN, eIF4E, FMRP, G3BP, LIN-28, PABP and TIAR are enriched in adult fly intestinal progenitor cells, where they accumulate in small cytoplasmic messenger ribonucleoprotein complexes (mRNPs).
Mon May 18 00:00:00 UTC 2020
Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast.
Journal of cell science
D'Ambrosio JM,Albanèse V,Lipp NF,Fleuriot L,Debayle D,Drin G,Čopič A
A-11122 was used in Western Blotting to show that Osh6 localization to contact sites depends on its interaction with the cytosolic tail of the ER-PM tether Ist2, a homolog of TMEM16 proteins.
Thu Jun 04 00:00:00 UTC 2020
STIM1 interacts with termini of Orai channels in a sequential manner.
Journal of cell science
Niu L,Wu F,Li K,Li J,Zhang SL,Hu J,Wang Q
A-11122 was used in Western Blotting to analyze STIM1-Orai interactions using synthetic peptides derived from the N- and C-termini of Orai channels (Orai-NT and Orai-CT, respectively) and purified fragments of STIM1.
Wed Apr 29 00:00:00 UTC 2020
Node-Localized Transporters of Phosphorus Essential for Seed Development in Rice.
Plant & cell physiology
Che J,Yamaji N,Miyaji T,Mitani-Ueno N,Kato Y,Shen RF,Ma JF
A-11122 was used in Immunocytochemistry to show that OsPHO1;2 expressed in node I is responsible for the unloading of P from the xylem of EVBs, while OsPHO1;1 is involved in reloading P into the phloem of DVBs for subsequent allocation of P to seeds.
Sat Aug 01 00:00:00 UTC 2020
Development of the intrinsic innervation of the small bowel mucosa and villi.
American journal of physiology. Gastrointestinal and liver physiology
Hao MM,Fung C,Boesmans W,Lowette K,Tack J,Vanden Berghe P
A-11122 was used in Immunohistochemistry to show that enteric neurites project into the lamina propria as early as E13.5 in the mouse, before development of the submucous plexus and before formation of intestinal villi.
Wed Jan 01 00:00:00 UTC 2020
NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
Cerebral cortex (New York, N.Y. : 1991)
Parcerisas A,Pujadas L,Ortega-Gascó A,Perelló-Amorós B,Viais R,Hino K,Figueiro-Silva J,La Torre A,Trullás R,Simó S,Lüders J,Soriano E
A-11122 was used in Western Blot to demonstrate a role for NCAM2 in dendritic formation and maintenance, and in neural polarization and migration, through interaction of NCAM2 with microtubule-associated proteins.
Mon May 18 00:00:00 UTC 2020
NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
Cerebral cortex (New York, N.Y. : 1991)
Parcerisas A,Pujadas L,Ortega-Gascó A,Perelló-Amorós B,Viais R,Hino K,Figueiro-Silva J,La Torre A,Trullás R,Simó S,Lüders J,Soriano E
A-11122 was used in Western Blot to demonstrate a role for NCAM2 in dendritic formation and maintenance, and in neural polarization and migration, through interaction of NCAM2 with microtubule-associated proteins.
Mon May 18 00:00:00 UTC 2020
Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury.
Cerebral cortex (New York, N.Y. : 1991)
Ueno M,Nakamura Y,Nakagawa H,Niehaus JK,Maezawa M,Gu Z,Kumanogoh A,Takebayashi H,Lu QR,Takada M,Yoshida Y
A-11122 was used in Immunohistochemistry to demonstrate that semaphorins function as axon repellents following SCI, and reveal a novel transcriptional mechanism for controlling semaphorin levels around injured neurons to create zones hostile to axon regrowth.
Thu Oct 01 00:00:00 UTC 2020
Identification of Split-GAL4 Drivers and Enhancers That Allow Regional Cell Type Manipulations of the Drosophila melanogaster Intestine.
Genetics
Ariyapala IS,Holsopple JM,Popodi EM,Hartwick DG,Kahsai L,Cook KR,Sokol NS
A-11122 was used in Western Blot to show that intestinal enhancers identified with the split-GAL4 system can confer equivalent expression patterns on other transgenic reporters.
Tue Dec 01 00:00:00 UTC 2020
Defining the Boundaries of Polycomb Domains in Drosophila.
Genetics
De S,Gehred ND,Fujioka M,Chan FW,Jaynes JB,Kassis JA
A-11122 was used in Immunohistochemistry to suggest that active transcription of a boundary gene may restrict the range of enhancer activity of a Polycomb-regulated gene.
Sun Nov 01 00:00:00 UTC 2020
Neuronal tangential migration from Nkx2.1-positive hypothalamus.
Brain structure & function
Murcia-Ramón R,Company V,Juárez-Leal I,Andreu-Cervera A,Almagro-García F,Martínez S,Echevarría D,Puelles E
A-11122 was used in Immunohistochemistry to describe the contribution of interneurons from the Nkx2.1-positive hypothalamic territory into two different rostrocaudal territories: the mes-diencephalic reticular formation through a caudal tangential migration and the prethalamic zona incerta complex through a dorsocaudal tangential migration.
Tue Dec 01 00:00:00 UTC 2020
Mutational Analysis of the Structure and Function of the Chaperoning Domain of UNC-45B.
Biophysical journal
Gaziova I,Moncrief T,Christian CJ,Villarreal M,Powell S,Lee H,Qadota H,White MA,Benian GM,Oberhauser AF
A-11122 was used in Immunohistochemistry to show that, to our surprise, the R805W mutation appeared to have the most drastic detrimental effect on the structure and organization of the worm sarcomeres, indicating a crucial role of R805 in UCS-client interactions.
Tue Aug 18 00:00:00 UTC 2020
Comparative analyses of transgene expression patterns after intra-striatal injections of rAAV2-retro in rats and rhesus monkeys: A light and electron microscopic study.
The European journal of neuroscience
Albaugh DL,Smith Y,Galvan A
A-11122 was used in Immunohistochemistry to evaluate the suitability of retrogradely-transducing viral vector rAAV2-retro in the nonhuman primate basal ganglia.
Tue Dec 01 00:00:00 UTC 2020
LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Molecular biology of the cell
Pollitt SL,Myers KR,Yoo J,Zheng JQ
A-11122 was used in Immunocytochemistry-immunoflourescence to determine the role of LIM and SH3 protein 1 (LASP1) in axon development through localisation along the leading edge of lamellipodia.
Sun Nov 15 00:00:00 UTC 2020
Mutations in the J domain of DNAJB6 cause dominant distal myopathy.
Neuromuscular disorders : NMD
Palmio J,Jonson PH,Inoue M,Sarparanta J,Bengoechea R,Savarese M,Vihola A,Jokela M,Nakagawa M,Noguchi S,Olivé M,Masingue M,Kerty E,Hackman P,Weihl CC,Nishino I,Udd B
A-11122 was used in Immuno-assay to identify two novel mutations in DNAJB6 J domain, c.149C>T (p.A50V) and c.161A>C (p.E54A) as the cause of distal myopathy.
Wed Jan 01 00:00:00 UTC 2020
Rewarding compounds identified from the medicinal plant Rhodiola rosea.
The Journal of experimental biology
Michels B,Franke K,Weiglein A,Sultani H,Gerber B,Wessjohann LA
A-11122 was used in Immunohistochemistry to discuss whether similar rewarding effects, should they be observed in humans, would indicate a habit-forming or addictive potential.
Wed Aug 26 00:00:00 UTC 2020
Characterizing the morphology of somatostatin-expressing interneurons and their synaptic innervation pattern in the barrel cortex of the GFP-expressing inhibitory neurons mouse.
The Journal of comparative neurology
Zhou X,Mansori I,Fischer T,Witte M,Staiger JF
A-11122 was used in Immunohistochemistry to reveal unique features in terms of the morphology and output of GIN cells, which can help to better understand their diversity and structure-function relationships.
Sat Feb 01 00:00:00 UTC 2020
Structural plasticity of GABAergic and glutamatergic networks in the motor thalamus of parkinsonian monkeys.
The Journal of comparative neurology
Swain AJ,Galvan A,Wichmann T,Smith Y
A-11122 was used in Immunohistochemistry to suggest that the corticothalamic system undergoes significant synaptic remodeling in the parkinsonian state.
Mon Jun 01 00:00:00 UTC 2020
Serotonergic modulation across sensory modalities.
Journal of neurophysiology
Sizemore TR,Hurley LM,Dacks AM
A-11122 was used in Immunohistochemistry to study different consequences of neuromodulation using serotonergic signaling pathways.
Mon Jun 01 00:00:00 UTC 2020
Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
Wang H,Foquet B,Dewell RB,Song H,Dierick HA,Gabbiani F
A-11122 was used in Immunohistochemistry to identify an ortholog in the transcriptome of Schistocerca.
Sun Mar 01 00:00:00 UTC 2020
STAT2 Limits Host Species Specificity of Human Metapneumovirus.
Viruses
Rogers MC,Miranda-Katz M,Zhang Y,Oury TD,Uccellini MB,García-Sastre A,Williams JV
A-11122 was used in Western Blotting to show that HMPV inhibits expression of both STAT1 and STAT2 in human and primate cells, but not in mouse cells.
Sat Jul 04 00:00:00 UTC 2020
A genetic, genomic, and computational resource for exploring neural circuit function.
eLife
Davis FP,Nern A,Picard S,Reiser MB,Rubin GM,Eddy SR,Henry GL
A-11122 was used in Immunohistochemistry to describe examples that include identifying neurotransmitters, including cases of apparent co-release, generating functional hypotheses based on receptor expression, as well as identifying strong commonalities between different cell types.
Wed Jan 15 00:00:00 UTC 2020
Nestin-GFP transgene labels skeletal progenitors in the periosteum.
Bone
Tournaire G,Stegen S,Giacomini G,Stockmans I,Moermans K,Carmeliet G,van Gastel N
A-11122 was used in Flow Cytometry to show that in adult mice, Nes-GFP cells are present in the periosteum and localize closely to blood vessels, but periosteal Nes-GFP cells express SSC and progenitor markers differently compared to Nes-GFP cells in the bone marrow.
Wed Apr 01 00:00:00 UTC 2020
Genome analysis of sphingolipid metabolism-related genes in Tetrahymena thermophila and identification of a fatty acid 2-hydroxylase involved in the sexual stage of conjugation.
Molecular microbiology
Cid NG,Puca G,Nudel CB,Nusblat AD
A-11122 was used in Immunocytochemistry to identify the fatty acid 2-hydroxylase gene in the sphingolipid metabolic pathway.
Sun Nov 01 00:00:00 UTC 2020
Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
Nature communications
Cooper A,Butto T,Hammer N,Jagannath S,Fend-Guella DL,Akhtar J,Radyushkin K,Lesage F,Winter J,Strand S,Roeper J,Zechner U,Schweiger S
A-11122 was used in Immunohistochemistry to suggest a potential approach to improve cognitive dysfunction in a mouse model of an imprinting disorder.
Fri Jan 24 00:00:00 UTC 2020
Mutations of CNTNAP1 led to defects in neuronal development.
JCI insight
Li W,Yang L,Tang C,Liu K,Lu Y,Wang H,Yan K,Qiu Z,Zhou W
A-11122 was used in Immunohistochemistry to elucidate a critical function of CNTNAP1 in cortical development, providing insights underlying molecular and circuit mechanisms of CNTNAP1-related disease.
Thu Nov 05 00:00:00 UTC 2020
Distinct Dorsal and Ventral Hippocampal CA3 Outputs Govern Contextual Fear Discrimination.
Cell reports
Besnard A,Miller SM,Sahay A
A-11122 was used in Immunohistochemistry to identify opposing roles for dorsal CA3-CA1 (dCA3-dCA1) projections and dorsal CA3-dorsolateral septum (dCA3-DLS) projections in calibrating fear responses to certain and ambiguous contextual threats, respectively.
Tue Feb 18 00:00:00 UTC 2020
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.
Nature communications
Zaninello M,Palikaras K,Naon D,Iwata K,Herkenne S,Quintana-Cabrera R,Semenzato M,Grespi F,Ross-Cisneros FN,Carelli V,Sadun AA,Tavernarakis N,Scorrano L
A-11122 was used in Immunocytochemistry, Flow Cytometry to identify AMPK and autophagy as targetable components of autosomal dominant optic atrophy (ADOA) pathogenesis.
Wed Aug 12 00:00:00 UTC 2020
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.
Nature communications
Zaninello M,Palikaras K,Naon D,Iwata K,Herkenne S,Quintana-Cabrera R,Semenzato M,Grespi F,Ross-Cisneros FN,Carelli V,Sadun AA,Tavernarakis N,Scorrano L
A-11122 was used in Immunocytochemistry, Flow Cytometry to identify AMPK and autophagy as targetable components of autosomal dominant optic atrophy (ADOA) pathogenesis.
Wed Aug 12 00:00:00 UTC 2020
A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.
The Journal of biological chemistry
Arias-Arias JL,MacPherson DJ,Hill ME,Hardy JA,Mora-Rodríguez R
A-11122 was used in Western Blotting to report the construction of fluorescence-activatable sensors to detect the activities of flavivirus NS2B-NS3 serine proteases in living cells.
Fri Feb 21 00:00:00 UTC 2020
RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.
The Journal of biological chemistry
Burke JM,Lester ET,Tauber D,Parker R
A-11122 was used in Immunoprecipitation to demonstrate that RLBs represent a unique RNP granule with a protein and RNA composition distinct from that of SGs in response to dsRNA lipofection in human cells, using immunofluorescence, live-cell imaging, and MS-based analyses.
Fri Feb 07 00:00:00 UTC 2020
Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory.
eLife
Wu Y,Funato Y,Meschi E,Jovanoski KD,Miki H,Waddell S
A-11122 was used in Immunohistochemistry-immunofluorescence to show that Mg2+ feeding also enhances long-term memory in Drosophila. Normal and Mg2+ enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg2+-efflux transporter encoded by the unextended (uex) gene.
Thu Nov 26 00:00:00 UTC 2020
Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior.
eNeuro
Akers AT,Cooper SY,Baumgard ZJ,Casinelli GP,Avelar AJ,Henderson BJ
A-11122 was used in Immunocytochemistry to show nicotine reward-related behavior is linked to nicotinic acetylcholine receptors upregulation and neuron firing frequency.
Fri Jun 18 00:00:00 UTC 2021
The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle.
eLife
Kantarci H,Gou Y,Riley BB
A-11122 was used in Immunohistochemistry to demonstrate that disrupting the glycolytic gene phosphoglycerate kinase-1 (pgk1) impairs Fgf-dependent development of hair cells and neurons in the otic vesicle and other neurons in the CNS/PNS.
Mon Apr 27 00:00:00 UTC 2020
A dual function of SnRK2 kinases in the regulation of SnRK1 and plant growth.
Nature plants
Belda-Palazón B,Adamo M,Valerio C,Ferreira LJ,Confraria A,Reis-Barata D,Rodrigues A,Meyer C,Rodriguez PL,Baena-González E
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to investigate SnRK2 and SnRK1 kinases in plant growth.
Sun Nov 01 00:00:00 UTC 2020
TERMINAL FLOWER 1-FD complex target genes and competition with FLOWERING LOCUS T.
Nature communications
Zhu Y,Klasfeld S,Jeong CW,Jin R,Goto K,Yamaguchi N,Wagner D
A-11122 was used in Chromatin immunoprecipitation to provide mechanistic insight into how TFL1-FD sculpt inflorescence architecture, a trait important for reproductive success, plant architecture and yield.
Mon Oct 12 00:00:00 UTC 2020
Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain.
Nature communications
Li HQ,Spitzer NC
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that neurotransmitter switching provides the basis by which sustained running benefits motor skill learning, presenting a target for clinical treatment of movement disorders.
Mon May 04 00:00:00 UTC 2020
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.
Nature metabolism
Brett JO,Arjona M,Ikeda M,Quarta M,de Morrée A,Egner IM,Perandini LA,Ishak HD,Goshayeshi A,Benjamin DI,Both P,Rodríguez-Mateo C,Betley MJ,Wyss-Coray T,Rando TA
A-11122 was used in Immunohistochemistry to investigate the effect of exercise on aged stem cell function in the context of tissue regeneration in old mice.
Wed Apr 01 00:00:00 UTC 2020
An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila.
Molecular brain
Liu Z,Chen Y,Rao Y
A-11122 was used in Immunohistochemistry-immunofluorescence to show neuroglian coordinates R-cell and wrapping glia development in the wrapping glia and eye disc.
Fri Jan 03 00:00:00 UTC 2020
Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation.
eLife
Stefanovic S,Laforest B,Desvignes JP,Lescroart F,Argiro L,Maurel-Zaffran C,Salgado D,Plaindoux E,De Bono C,Pazur K,Théveniau-Ruissy M,Béroud C,Puceat M,Gavalas A,Kelly RG,Zaffran S
A-11122 was used in Immunocytochemistry to profile the transcriptome and chromatin accessibility of anterior and posterior SHF sub-populations at genome-wide levels and demonstrate that Hoxb1 negatively regulates differentiation in the posterior SHF.
Mon Aug 17 00:00:00 UTC 2020
Smchd1 is a maternal effect gene required for genomic imprinting.
eLife
Wanigasuriya I,Gouil Q,Kinkel SA,Tapia Del Fierro A,Beck T,Roper EA,Breslin K,Stringer J,Hutt K,Lee HJ,Keniry A,Ritchie ME,Blewitt ME
A-11122 was used in Immunocytochemistry, ChIP assay to report epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expression of ten genes in mice.
Fri Nov 13 00:00:00 UTC 2020
Smchd1 is a maternal effect gene required for genomic imprinting.
eLife
Wanigasuriya I,Gouil Q,Kinkel SA,Tapia Del Fierro A,Beck T,Roper EA,Breslin K,Stringer J,Hutt K,Lee HJ,Keniry A,Ritchie ME,Blewitt ME
A-11122 was used in Immunocytochemistry, ChIP assay to report epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expression of ten genes in mice.
Fri Nov 13 00:00:00 UTC 2020
Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism.
Cell reports
Soh GH,Pomreinke AP,Müller P
A-11122 was used in Western Blotting to show that Smad2 and Smad5 antagonize each other for specific cell fates, providing a mechanism for how cells integrate and discriminate between overlapping signals during development.
Tue Apr 07 00:00:00 UTC 2020
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
eLife
Zhang RS,Liakath-Ali K,Südhof TC
A-11122 was used in Western Blot to demonstrate that Lphn2 and Lphn3 are selectively but redundantly required in Purkinje cells for parallel-fiber synapses.
Mon Mar 23 00:00:00 UTC 2020
Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit.
Nature communications
Jo YS,Namboodiri VMK,Stuber GD,Zweifel LS
A-11122 was used in Immunohistochemistry to demonstrate CeA-CRF neurons are an important substrate for the persistence of fear and have broad implications for the neural basis of persistent negative affective behavioral states.
Wed Jan 22 00:00:00 UTC 2020
Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle.
mBio
Smith EP,Cotto-Rosario A,Borghesan E,Held K,Miller CN,Celli J
A-11122 was used in Western Blotting to demonstrate that T4SS effectors BspB and RicA display epistatic interactions in Brucella replication.
Tue Mar 31 00:00:00 UTC 2020
Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning.
eLife
Peak J,Chieng B,Hart G,Balleine BW
A-11122 was used in Immunohistochemistry to support response flexibility.
Fri Nov 20 00:00:00 UTC 2020
Distributed control of motor circuits for backward walking in Drosophila.
Nature communications
Feng K,Sen R,Minegishi R,Dübbert M,Bockemühl T,Büschges A,Dickson BJ
A-11122 was used in Immunohistochemistry to identify several dozen MDN target neurons within the leg motor circuits, and show that two of them mediate distinct and highly-specific changes in leg muscle activity during backward walking: LBL40 neurons provide the hindleg power stroke during stance phase; LUL130 neurons lift the legs at the end of stance to initiate swing.
Wed Dec 02 00:00:00 UTC 2020
Subnuclear gene positioning through lamina association affects copper tolerance.
Nature communications
Sakamoto Y,Sato M,Sato Y,Harada A,Suzuki T,Goto C,Tamura K,Toyooka K,Kimura H,Ohkawa Y,Hara-Nishimura I,Takagi S,Matsunaga S
A-11122 was used in Immunomicroscopy to study the biological function of CROWDED NUCLEI in Arabidopsis thaliana.
Fri Nov 20 00:00:00 UTC 2020
Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.
eNeuro
Murray KD,Liu XB,King AN,Luu JD,Cheng HJ
A-11122 was used in Immunohistochemistry to describe the maturation of mossy fiber bouton (MFB) connectivity with CA3 pyramidal cells in young adult and aged mouse brain.
Thu Aug 31 00:00:00 UTC 2023
The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
Nature communications
Moody JC,Qadota H,Reedy AR,Okafor CD,Shanmugan N,Matsunaga Y,Christian CJ,Ortlund EA,Benian GM
A-11122 was used in Immunocytochemistry to show that a PIX protein has an important function in muscle.
Tue Oct 06 00:00:00 UTC 2020
Coordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching.
eLife
Ricolo D,Araujo SJ
A-11122 was used in Immunohistochemistry to provide the first evidence for a role for spectraplakins in single-cell lumen formation and branching.
Wed Oct 28 00:00:00 UTC 2020
Hindbrain Double-Negative Feedback Mediates Palatability-Guided Food and Water Consumption.
Cell
Gong R,Xu S,Hermundstad A,Yu Y,Sternson SM
A-11122 was used in Immunohistochemistry to identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensitive and hydration-sensitive cell populations.
Thu Sep 17 00:00:00 UTC 2020
TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.
BMC biology
Romano G,Klima R,Feiguin F
A-11122 was used in Western Blotting to describe a novel physiological role of endogenous TDP-43 in the prevention of RTE-induced neurological alterations through the modulation of Dicer-2 activity and the siRNA pathway.
Fri Jul 03 00:00:00 UTC 2020
Immunopurification of Intact Endosomal Compartments for Lipid Analyses in Arabidopsis.
Methods in molecular biology (Clifton, N.J.)
Ito Y,Grison M,Esnay N,Fouillen L,Boutté Y
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to describe and discuss the immunoprecipitation protocol to isolate endosomes with the aim to analyze lipid content.
Thu Mar 18 00:00:00 UTC 2021
Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis.
Communications biology
Rosendo-Pineda MJ,Vicente JJ,Vivas O,Pacheco J,Loza-Huerta A,Sampieri A,Wordeman L,Moreno C,Vaca L
A-11122 was used in Immunoprecipitation to investigate the role of NMDA receptors during mitosis in individual cells.
Thu Nov 12 00:00:00 UTC 2020
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.
eLife
Wolf G,de Iaco A,Sun MA,Bruno M,Tinkham M,Hoang D,Mitra A,Ralls S,Trono D,Macfarlan TS
A-11122 was used in Chromatin immunoprecipitation to demonstrate that many recently emerged murine KRAB-ZFPs also bind to TEs, including the active ETn, IAP, and L1 families.
Mon Jun 01 00:00:00 UTC 2020
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
Nature communications
Mishra V,Re DB,Le Verche V,Alvarez MJ,Vasciaveo A,Jacquier A,Doulias PT,Greco TM,Nizzardo M,Papadimitriou D,Nagata T,Rinchetti P,Perez-Torres EJ,Politi KA,Ikiz B,Clare K,Than ME,Corti S,Ischiropoulos H,Lotti F,Califano A,Przedborski S
A-11122 was used in Immunocytochemistry-immunoflourescence to support the usefulness of integrative, systems biology approach to gain insights into complex neurobiological disease processes as in ALS and posit that the proposed methodology is not restricted to this biological context and could be used in a variety of other non-cell-autonomous communication mechanisms.
Wed Nov 04 00:00:00 UTC 2020
Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii.
Malaria journal
Bowman LM,Finger LE,Hart KJ,Lindner SE
A-11122 was used in Immunocytochemistry-immunoflourescence to indicate that achieving stage-specific effects, such as gene editing, is likely best done using a two-component system with independent promoter activities overlapping only in the intended life cycle stage.
Mon Nov 23 00:00:00 UTC 2020
A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma.
Cell death & disease
Feng Y,Zhang Y,Cai Y,Liu R,Lu M,Li T,Fu Y,Guo M,Huang H,Ou Y,Chen Y
A-11122 was used in Immunohistochemistry to establish A20 as a critical regulator of glycolysis and reveal a novel mechanism for A20 in tumor suppression and PFKL regulation.
Mon Feb 03 00:00:00 UTC 2020
Behavioral effects of SGK1 knockout in VTA and dopamine neurons.
Scientific reports
Doyle MA,Stark AR,Fejes-Tóth G,Náray-Fejes-Tóth A,Mazei-Robison MS
A-11122 was used in Western Blotting to investigate the effect of SGK1 knockout in the ventral tegmental area (VTA) and in dopamine (DA) neurons to evaluate the necessity of protein expression for natural and drug reward behaviors.
Tue Sep 08 00:00:00 UTC 2020
The Isolation of Stress Granules From Plant Material.
Current protocols in plant biology
Kosmacz M,Skirycz A
A-11122 was used in Immunopurification to describe an isolation protocol of stress granules that allows for the identification of proteins, mRNA, and metabolites sequestered into stress granules cores.
Tue Sep 01 00:00:00 UTC 2020
Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization.
The Journal of biological chemistry
Kuwana T,King LE,Cosentino K,Suess J,Garcia-Saez AJ,Gilmore AP,Newmeyer DD
A-11122 was used in Immunocytochemistry-immunoflourescence to conclude that BAX’s mitochondrial residence in vivo, regulated by both targeting and retrotranslocation, is more significant for its pro-apoptotic activity than its ability to insert and to form higher-order oligomers in model membranes.
Fri Feb 07 00:00:00 UTC 2020
Decapentaplegic signaling regulates Wingless ligand production and target activation during Drosophila wing development.
FEBS letters
Li Y,Zhang F,Jiang N,Liu T,Shen J,Zhang J
A-11122 was used in Immunohistochemistry to support a model in which decapentaplegic (Dpp) signaling plays a dual role in transcriptional regulation of both the wingless (wg) gene and downstream targets.
Wed Apr 01 00:00:00 UTC 2020
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.
Scientific reports
Dripps IJ,Bertels Z,Moye LS,Tipton AF,Siegersma K,Baca SM,Kieffer BL,Pradhan AA
A-11122 was used in Immunohistochemistry to indicate that forebrain DORs are necessary for the action of DOR agonists in relieving headache-related symptoms and suggest that forebrain regions may play an important role in migraine modulation.
Mon Oct 19 00:00:00 UTC 2020
A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology.
F1000Research
Gonçalves-Pimentel C,Mazaud D,Kottler B,Proelss S,Hirth F,Fanto M
A-11122 was used in Immunocytochemistry to establish that garz is necessary in many glial cell types, that it affects motor behaviour and, at the sub-cellular level, is responsible for defects in cellular membranes, autophagy and mitochondria quality control.
Mon Mar 15 00:00:00 UTC 2021
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.
eLife
Stephani M,Picchianti L,Gajic A,Beveridge R,Skarwan E,Sanchez de Medina Hernandez V,Mohseni A,Clavel M,Zeng Y,Naumann C,Matuszkiewicz M,Turco E,Loefke C,Li B,Dürnberger G,Schutzbier M,Chen HT,Abdrakhmanov A,Savova A,Chia KS,Djamei A,Schaffner I,Abel S,Jiang L,Mechtler K,Ikeda F,Martens S,Clausen T,Dagdas Y
A-11122 was used in Immunohistochemistry to discover that C53 forms an ancient quality control pathway that bridges selective autophagy with ribosome-associated quality control in the endoplasmic reticulum.
Thu Aug 27 00:00:00 UTC 2020
Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation.
Cell reports
Bi Y,Tu Z,Zhang Y,Yang P,Guo M,Zhu X,Zhao C,Zhou J,Wang H,Wang Y,Gao S
A-11122 was used in Flow cytometry/Cell sorting to identify a functional surface marker for human naive pluripotency.
Tue Mar 17 00:00:00 UTC 2020
Removal of H2Aub1 by ubiquitin-specific proteases 12 and 13 is required for stable Polycomb-mediated gene repression in Arabidopsis.
Genome biology
Kralemann LEM,Liu S,Trejo-Arellano MS,Muñoz-Viana R,Köhler C,Hennig L
A-11122 was used in Chromatin immunoprecipitation to investigate the collaborative nature of UBP12/13, PRC1/2 and EMF1 in repressing genes involved within the response to stimuli within arabidopsis.
Tue Jun 16 00:00:00 UTC 2020
Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores.
Nature communications
Mudumbi KC,Czapiewski R,Ruba A,Junod SL,Li Y,Luo W,Ngo C,Ospina V,Schirmer EC,Yang W
A-11122 was used in Western Blotting to suggest that peripheral channel transport is the default mechanism that was adapted in evolution to include aspects of receptor-mediated central channel transport for directed trafficking of certain membrane proteins.
Mon May 04 00:00:00 UTC 2020
Divergent receptor proteins confer responses to different karrikins in two ephemeral weeds.
Nature communications
Sun YK,Yao J,Scaffidi A,Melville KT,Davies SF,Bond CS,Smith SM,Flematti GR,Waters MT
A-11122 was used in Western Blotting to suggest that duplication and diversification of KAI2 proteins could confer differential responses to chemical cues produced by environmental disturbance, including fire.
Mon Mar 09 00:00:00 UTC 2020
Action representation in the mouse parieto-frontal network.
Scientific reports
Tombaz T,Dunn BA,Hovde K,Cubero RJ,Mimica B,Mamidanna P,Roudi Y,Whitlock JR
A-11122 was used in Immunohistochemistry to investigate whether mirror-like neurons occur in similar networks in other social species, such as rodents, or if they can be measured in such models using paradigms where observers passively view a demonstrator.
Fri Mar 27 00:00:00 UTC 2020
Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.
Scientific reports
Chang YC,Tu H,Huang TW,Xu BW,Pi H
A-11122 was used in Immunohistochemistry to show that tumor necrosis factor Eiger (Egr) is upregulated in testicular smooth muscles as a response to prolonged protein starvation in Drosophila testis.
Wed Jul 15 00:00:00 UTC 2020
Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.
Cell reports
Shoffner A,Cigliola V,Lee N,Ou J,Poss KD
A-11122 was used in Immunohistochemistry-immunofluorescence to show that myocardial Tp53 suppression by mitogen-induced Mdm2 is a regulatory component of innate cardiac regeneration.
Tue Sep 01 00:00:00 UTC 2020
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output.
Nature communications
Udakis M,Pedrosa V,Chamberlain SEL,Clopath C,Mellor JR
A-11122 was used in Immunohistochemistry to show that circuit-level modelling reveals that PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multiple unique environments within the hippocampal network.
Wed Sep 02 00:00:00 UTC 2020
MRG1/2 histone methylation readers and HD2C histone deacetylase associate in repression of the florigen gene FT to set a proper flowering time in response to day-length changes.
The New phytologist
Guo Z,Li Z,Liu Y,An Z,Peng M,Shen WH,Dong A,Yu Y
A-11122 was used in Western Blot to investigate histone methylation in circadian rhythm for regulation of Flowering Locus T in Arabidopsis.
Tue Sep 01 00:00:00 UTC 2020
Efficient Strategies for Microglia Replacement in the Central Nervous System.
Cell reports
Xu Z,Rao Y,Huang Y,Zhou T,Feng R,Xiong S,Yuan TF,Qin S,Lu Y,Zhou X,Li X,Qin B,Mao Y,Peng B
A-11122 was used in Immunohistochemistry to develop three efficient strategies for microglia replacement: microglia replacement by bone marrow transplantation (mrBMT), microglia replacement by peripheral blood (mrPB), and microglia replacement by microglia transplantation (mrMT).
Tue Aug 11 00:00:00 UTC 2020
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis.
Cell death & disease
Bugallo R,Marlin E,Baltanás A,Toledo E,Ferrero R,Vinueza-Gavilanes R,Larrea L,Arrasate M,Aragón T
A-11122 was used in Immunocytochemistry-immunoflourescence to identify ISRIB-mediated translational reprogramming as a new potential ALS therapy.
Tue May 26 00:00:00 UTC 2020
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis.
Cell death & disease
Bugallo R,Marlin E,Baltanás A,Toledo E,Ferrero R,Vinueza-Gavilanes R,Larrea L,Arrasate M,Aragón T
A-11122 was used in Immunocytochemistry-immunoflourescence to identify ISRIB-mediated translational reprogramming as a new potential ALS therapy.
Tue May 26 00:00:00 UTC 2020
Light microscopy of proteins in their ultrastructural context.
Nature communications
M'Saad O,Bewersdorf J
A-11122 was used in Immunocytochemistry-immunoflourescence to report the discovery of a new principle for an optical contrast equivalent to electron microscopy (EM) which reveals the ultrastructural context of the cells with a conventional confocal microscope.
Fri Jul 31 00:00:00 UTC 2020
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo.
eLife
Bressan C,Pecora A,Gagnon D,Snapyan M,Labrecque S,De Koninck P,Parent M,Saghatelyan A
A-11122 was used in Immunohistochemistry-immunofluorescence to show that autophagy and energy consumption act in concert in migrating cells to dynamically regulate the pace and periodicity of the migratory and stationary phases to sustain neuronal migration.
Mon Sep 28 00:00:00 UTC 2020
Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.
Nature communications
Hsu HL,Brown A,Loveland AB,Lotun A,Xu M,Luo L,Xu G,Li J,Ren L,Su Q,Gessler DJ,Wei Y,Tai PWL,Korostelev AA,Gao G
A-11122 was used in Immunohistochemistry (Frozen) to describe a novel capsid identified in a human clinical sample by high-throughput, long-read sequencing.
Tue Jun 30 00:00:00 UTC 2020
DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.
Cell reports
Christian DL,Wu DY,Martin JR,Moore JR,Liu YR,Clemens AW,Nettles SA,Kirkland NM,Papouin T,Hill CA,Wozniak DF,Dougherty JD,Gabel HW
A-11122 was used in Western Blotting to investigate the effects of DNA methyltransferase 3A mutations when associated with neurodevelopmental disease.
Tue Nov 24 00:00:00 UTC 2020
Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling.
Skeletal muscle
Caputo L,Granados A,Lenzi J,Rosa A,Ait-Si-Ali S,Puri PL,Albini S
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that acute conversion of Duchenne muscular dystrophy (DMD) patient-derived iPSC into skeletal muscles, by the ectopic expression of MyoD and BAF60C, provides a rapid and reliable protocol for an “in dish” DMD model.
Sat May 02 00:00:00 UTC 2020
Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.
Scientific reports
Han D,Kwon M,Lee SM,Pleasure SJ,Yoon K
A-11122 was used in Immunocytochemistry-Immunofluorescence experiments to show that constitutive YAP activation by in utero introduction of a non-degradable form of the YAP gene (YAP 5SA) causes productive GFAP+ cell generation at late embryonic periods, and this activity is nuclear localization- and TEAD transcription factor-dependent.
Mon Apr 27 00:00:00 UTC 2020
Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.
Scientific reports
Han D,Kwon M,Lee SM,Pleasure SJ,Yoon K
A-11122 was used in Immunocytochemistry-Immunofluorescence experiments to show that constitutive YAP activation by in utero introduction of a non-degradable form of the YAP gene (YAP 5SA) causes productive GFAP+ cell generation at late embryonic periods, and this activity is nuclear localization- and TEAD transcription factor-dependent.
Mon Apr 27 00:00:00 UTC 2020
Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila.
Molecular cell
Wei L,Lee S,Majumdar S,Zhang B,Sanfilippo P,Joseph B,Miura P,Soller M,Lai EC
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to demonstrate how regulatory interplay and functionally overlapping activities of neural ELAV/Hu RBPs drives the neural APA landscape.
Thu Oct 01 00:00:00 UTC 2020
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells.
Current research in immunology
Khan MM,Välikangas T,Khan MH,Moulder R,Ullah U,Bhosale SD,Komsi E,Butt U,Qiao X,Westermarck J,Elo LL,Lahesmaa R
A-11122 was used in Proximity Ligation Assay (PLA) to present the first systematic characterization of the CIP2A interactome by affinity-purification mass spectrometry combined with validation by selected reaction monitoring targeted mass spectrometry (SRM-MS) analysis in T helper (Th) 17 (Th17) cells.
Tue Dec 01 00:00:00 UTC 2020
Cytoplasmic sharing through apical membrane remodeling.
eLife
Peterson NG,Stormo BM,Schoenfelder KP,King JS,Lee RR,Fox DT
A-11122 was used in Immunocytochemistry to reveal a new role for apical membrane remodeling in converting a multicellular epithelium into a giant multinucleate cytoplasm.
Wed Oct 14 00:00:00 UTC 2020
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.
eLife
Chang LS,Kim M,Glinka A,Reinhard C,Niehrs C
A-11122 was used in Western Blot to identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa, as a Wnt inhibitor in human cancer cells and in the Spemann organizer of Xenopus embryos.
Tue Jan 14 00:00:00 UTC 2020
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.
Scientific reports
Walsh S,Izquierdo-Serra M,Acosta S,Edo A,Lloret M,Moret R,Bosch E,Oliva B,Bertranpetit J,Fernández-Fernández JM
A-11122 was used in Immunocytochemistry to describe the functional consequences of two non-synonymous genetic variants (R278Q and R378W) found to be under strong positive selection in an Ethiopian population, the Gumuz.
Wed Dec 02 00:00:00 UTC 2020
Conservation and divergence of related neuronal lineages in the Drosophila central brain.
eLife
Lee YJ,Yang CP,Miyares RL,Huang YF,He Y,Ren Q,Chen HM,Kawase T,Ito M,Otsuna H,Sugino K,Aso Y,Ito K,Lee T
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate how lineage identity translates to neuron morphology in Drosophila central brain lineages.
Tue Apr 07 00:00:00 UTC 2020
2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.
International journal of molecular sciences
Lee YJ,Kim HR,Lee CY,Hyun SA,Ko MY,Lee BS,Hwang DY,Ka M
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate the molecular mechanism of the antidepressant effect of 2-Phenethylamine(PEA) in a mouse model of corticosterone-induced depression.
Mon Nov 30 00:00:00 UTC 2020
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Nature communications
Lõhmussaar K,Kopper O,Korving J,Begthel H,Vreuls CPH,van Es JH,Clevers H
A-11122 was used in Immunohistochemistry-immunofluorescence to show in vitro drug testing reveals distinct lineage-dependent sensitivities to the common drugs used to treat HG-SOC in patients.
Wed May 27 00:00:00 UTC 2020
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Nature communications
Zhang J,Gurusaran M,Fujiwara Y,Zhang K,Echbarthi M,Vorontsov E,Guo R,Pendlebury DF,Alam I,Livera G,Emmanuelle M,Wang PJ,Nandakumar J,Davies OR,Shibuya H
A-11122 was used in Immunoprecipitation to identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association.
Tue Apr 28 00:00:00 UTC 2020
Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.
International journal of molecular sciences
Gierke K,von Wittgenstein J,Hemmerlein M,Atorf J,Joachimsthaler A,Kremers J,Cooper BH,Varoqueaux F,Regus-Leidig H,Brandstätter JH
A-11122 was used in Immunocytochemistry-immunoflourescence to use knock-in Munc13-EXFP mice to suggest that retinal synapses operate with a single Munc13 isoform, however type 6 ON bipolar cells express two Munc13 isoforms in their synaptic terminals.
Thu Oct 22 00:00:00 UTC 2020
Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber.
Nutrients
Saito H,Toyoda Y,Takada T,Hirata H,Ota-Kontani A,Miyata H,Kobayashi N,Tsuchiya Y,Suzuki H
A-11122 was used in Western Blotting to investigate the URAT1-inhibitory effects of 25 FAs that are commonly contained in foods or produced in the body.
Fri May 29 00:00:00 UTC 2020
Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.
Nature communications
Kaur S,De Luca R,Khanday MA,Bandaru SS,Thomas RC,Broadhurst RY,Venner A,Todd WD,Fuller PM,Arrigoni E,Saper CB
A-11122 was used in Immunohistochemistry-immunofluorescence to indicate that the serotonergic input from the dorsal raphe to the parabrachial nucleus is critical for modulating the sensitivity of the PBelCGRP neurons that cause arousal to rising levels of blood CO2 during hypercapnia.
Tue Jun 02 00:00:00 UTC 2020
Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae.
eLife
Hampel S,Eichler K,Yamada D,Bock DD,Kamikouchi A,Seeds AM
A-11122 was used in Immunohistochemistry-immunofluorescence to show that the subpopulations project to different, discrete zones in the brain and differ in their responses to mechanical stimulation of the antennae.
Mon Oct 26 00:00:00 UTC 2020
Down-regulation of Beclin1 promotes direct cardiac reprogramming.
Science translational medicine
Wang L,Ma H,Huang P,Xie Y,Near D,Wang H,Xu J,Yang Y,Xu Y,Garbutt T,Zhou Y,Liu Z,Yin C,Bressan M,Taylor JM,Liu J,Qian L
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to reveal an inductive role of Atg5-dependent autophagy as well as a previously unrecognized autophagy-independent inhibitory function of Becn1 in iCM reprogramming.
Wed Oct 21 00:00:00 UTC 2020
Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster.
Cell reports
Jacobs JA,Sehgal A
A-11122 was used in Immunohistochemistry to reveal the role of arachidonic acid in seizure protection and identify a cannabinoid-receptor-1/2-independent mechanism of endocannabinoid seizure protection.
Tue Jun 02 00:00:00 UTC 2020
The epidermis coordinates thermoresponsive growth through the phyB-PIF4-auxin pathway.
Nature communications
Kim S,Hwang G,Kim S,Thi TN,Kim H,Jeong J,Kim J,Kim J,Choi G,Oh E
A-11122 was used in Chromatin immunoprecipitation to show that epidermis-specific expression of PIF4 induces constitutive long hypocotyls, while vasculature-specific expression of PIF4 has no effect on hypocotyl growth.
Wed Feb 26 00:00:00 UTC 2020
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
Nature communications
Sarkar TJ,Quarta M,Mukherjee S,Colville A,Paine P,Doan L,Tran CM,Chu CR,Horvath S,Qi LS,Bhutani N,Rando TA,Sebastiano V
A-11122 was used in Immunocytochemistry to show that transient expression of nuclear reprogramming factors, mediated by expression of mRNAs, promotes a rapid and broad amelioration of cellular aging.
Tue Mar 24 00:00:00 UTC 2020
GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation.
Cell reports
Choi BR,Cave C,Na CH,Sockanathan S
A-11122 was used in Immunohistochemistry on frozen tissues to show that Glycerophosphodiester phosphodiesterase 2 (GDE2) signaling underlies a neuronal pathway that promotes oligodendrocyte maturation through the release of soluble neuronally derived factors.
Tue May 05 00:00:00 UTC 2020
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice.
Nature communications
Nabel EM,Garkun Y,Koike H,Sadahiro M,Liang A,Norman KJ,Taccheri G,Demars MP,Im S,Caro K,Lopez S,Bateh J,Hof PR,Clem RL,Morishita H
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior.
Fri Aug 07 00:00:00 UTC 2020
Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics.
Molecular systems biology
Bravo González-Blas C,Quan XJ,Duran-Romaña R,Taskiran II,Koldere D,Davie K,Christiaens V,Makhzami S,Hulselmans G,de Waegeneer M,Mauduit D,Poovathingal S,Aibar S,Aerts S
A-11122 was used in Immunohistochemistry-immunofluorescence to provide a comprehensive spatial characterization of gene regulation in a 2D tissue.
Fri May 01 00:00:00 UTC 2020
The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway.
eLife
Stührwohldt N,Scholl S,Lang L,Katzenberger J,Schumacher K,Schaller A
A-11122 was used in Western Blotting to investigate the influence of the secretory pathway on peptide biogenesis.
Thu Apr 16 00:00:00 UTC 2020
Autophagy Activation in Zebrafish Heart Regeneration.
Scientific reports
Chávez MN,Morales RA,López-Crisosto C,Roa JC,Allende ML,Lavandero S
A-11122 was used in Immunohistochemistry to show that a tightly regulated autophagic response is triggered upon injury and during the early stages of the regeneration process.
Mon Feb 10 00:00:00 UTC 2020
ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Nature communications
Gacem N,Kavo A,Zerad L,Richard L,Mathis S,Kapur RP,Parisot M,Amiel J,Dufour S,de la Grange P,Pingault V,Vallat JM,Bondurand N
A-11122 was used in Immunohistochemistry to report that adenosine deaminase acting on RNA (ADAR1), responsible for adenosine-to-inosine editing of RNA, is required for regulating the development of two neural crest derivatives: melanocytes and Schwann cells.
Fri Jan 10 00:00:00 UTC 2020
Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen.
PloS one
McCullock TW,MacLean DM,Kammermeier PJ
A-11122 was used in Western Blot to assess the ability of these two proteins, along with mCherry, to act as a FRET acceptor for the bright, monomeric, green-yellow FP mNeonGreen using intensiometric FRET and 2-photon Fluorescent Lifetime Imaging Microscopy (FLIM) FRET techniques.
Mon Apr 27 00:00:00 UTC 2020
Small heat shock proteins determine synapse number and neuronal activity during development.
PloS one
Santana E,de Los Reyes T,Casas-Tintó S
A-11122 was used in Immunohistochemistry-immunofluorescence to explore the role of two small-HSPs (sHSPs), sHSP23 and sHSP26 in synaptogenesis and neuronal activity.
Mon Aug 24 00:00:00 UTC 2020
Mutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans.
G3 (Bethesda, Md.)
Uebel CJ,Agbede D,Wallis DC,Phillips CM
A-11122 was used in Immunocytochemistry to reveal that punctate Mutator foci arise in the progenitor germ cells of early embryos and persist throughout all larval stages.
Mon Oct 05 00:00:00 UTC 2020
Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity.
eLife
He L,Kooistra R,Das R,Oudejans E,van Leen E,Ziegler J,Portegies S,de Haan B,van Regteren Altena A,Stucchi R,Altelaar AM,Wieser S,Krieg M,Hoogenraad CC,Harterink M
A-11122 was used in Immunocytochemistry-immunoflourescence to study how organization of the microtubule cytoskeleton is established and maintained.
Wed Apr 15 00:00:00 UTC 2020
Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes.
JCI insight
Piperno GM,Naseem A,Silvestrelli G,Amadio R,Caronni N,Cervantes-Luevano KE,Liv N,Klumperman J,Colliva A,Ali H,Graziano F,Benaroch P,Haecker H,Hanna RN,Benvenuti F
A-11122 was used in Immunocytochemistry-immunoflourescence to show that immune complexes of self-DNA and autoantibodies (DNA-ICs) contribute to elevated IFN levels via activation of the cGAS/STING pathway of cytosolic sensing.
Thu Sep 03 00:00:00 UTC 2020
Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
Cerebral cortex (New York, N.Y. : 1991)
Pahle J,Muhia M,Wagener RJ,Tippmann A,Bock HH,Graw J,Herz J,Staiger JF,Drakew A,Kneussel M,Rune GM,Frotscher M,Brunne B
A-11122 was used in Immunohistochemistry-immunofluorescence to show that IN-specific Reelin knockout mice exhibit normal neuronal layering and normal behavior, including spatial reference memory.
Sat Mar 14 00:00:00 UTC 2020
Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain.
eLife
Cabañero D,Ramírez-López A,Drews E,Schmöle A,Otte DM,Wawrzczak-Bargiela A,Huerga Encabo H,Kummer S,Ferrer-Montiel A,Przewlocki R,Zimmer A,Maldonado R
A-11122 was used in Immunohistochemistry (Frozen) to study the role of the cannabinoid 2 receptor in regulating spontaneous neuropathic pain through allowing self administration of a CB2 agonist in wildtype and CB2 knockout mice models.
Mon Jul 20 00:00:00 UTC 2020
Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.
Communications biology
Ota R,Kobayashi S
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that Myc plays an important role in eliminating germline cells in the context of hybrid dysgenesis (HD).
Wed Apr 22 00:00:00 UTC 2020
TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease.
Cell reports
Zhu G,Harischandra DS,Ghaisas S,Zhang P,Prall W,Huang L,Maghames C,Guo L,Luna E,Mack KL,Torrente MP,Luk KC,Shorter J,Yang X
A-11122 was used in Immunohistochemistry to define TRIMs as a potent and multifunctional protein quality-control system in metazoa, which might be applied to treat neurodegenerative diseases.
Tue Dec 01 00:00:00 UTC 2020
SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation.
Cell reports
Ros O,Baudet S,Zagar Y,Loulier K,Roche F,Couvet S,Aghaie A,Atkins M,Louail A,Petit C,Metin C,Mechulam Y,Nicol X
A-11122 was used in Immunohistochemistry, Immunocytochemistry to investigate local calcium signaling in vivo and directly manipulate this second messenger for therapeutic use.
Tue Jul 21 00:00:00 UTC 2020
SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation.
Cell reports
Ros O,Baudet S,Zagar Y,Loulier K,Roche F,Couvet S,Aghaie A,Atkins M,Louail A,Petit C,Metin C,Mechulam Y,Nicol X
A-11122 was used in Immunohistochemistry, Immunocytochemistry to investigate local calcium signaling in vivo and directly manipulate this second messenger for therapeutic use.
Tue Jul 21 00:00:00 UTC 2020
Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex.
Scientific reports
Cho J,Ryu S,Lee S,Kim J,Kim HI
A-11122 was used in Immunohistochemistry to show that low doses of CLZ (0.1 and 0.01 mg/kg) successfully induced neural responses without off-target effects.
Tue Apr 07 00:00:00 UTC 2020
In vivo-directed evolution of adeno-associated virus in the primate retina.
JCI insight
Byrne LC,Day TP,Visel M,Strazzeri JA,Fortuny C,Dalkara D,Merigan WH,Schaffer DV,Flannery JG
A-11122 was used in Immunohistochemistry to demonstrate vectors with redirected tropism to the outer retina lead to increased gene delivery efficiency to retinal cells.
Thu May 21 00:00:00 UTC 2020
Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum.
Cells
Fernando S,Allan CY,Mroczek K,Pearce X,Sanislav O,Fisher PR,Annesley SJ
A-11122 was used in Immunocytochemistry-immunoflourescence to show that the C-terminus of α-synuclein is required and sufficient for the localisation of the protein to the cell cortex in D. discoideum.
Wed Oct 14 00:00:00 UTC 2020
Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.
PLoS genetics
Martínez BA,Hoyle RG,Yeudall S,Granade ME,Harris TE,Castle JD,Leitinger N,Bland ML
A-11122 was used in Western Blot to establish that Toll signaling induces a shift in anabolic lipid metabolism to favor phospholipid synthesis and ER expansion that may serve the immediate demand for AMP synthesis and secretion but with the long-term consequence of insufficient nutrient storage.
Sun Nov 01 00:00:00 UTC 2020
Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission.
Life science alliance
Guttery DS,Pandey R,Ferguson DJ,Wall RJ,Brady D,Gupta D,Holder AA,Tewari R
A-11122 was used in Western Blotting to characterized in-depth the location and function of DEH, applying in silico analysis, live cell imaging, reverse genetics, and ultrastructure analysis using the mouse malaria model Plasmodium berghei.
Tue Dec 01 00:00:00 UTC 2020
Three-Dimensional Imaging and Gene Expression Analysis Upon Enzymatic Isolation of the Tongue Epithelium.
Frontiers in physiology
Meisel CT,Pagella P,Porcheri C,Mitsiadis TA
A-11122 was used in Immunocytochemistry to analyse the multicellular compartmentalisation of isolated tongue epithelium by three-dimensional fluorescent imaging and quantitative real time PCR.
Mon Sep 28 00:00:00 UTC 2020
Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons.
Cell
Del Toro D,Carrasquero-Ordaz MA,Chu A,Ruff T,Shahin M,Jackson VA,Chavent M,Berbeira-Santana M,Seyit-Bremer G,Brignani S,Kaufmann R,Lowe E,Klein R,Seiradake E
A-11122 was used in Western Blot to show that binding of Latrophilins to Teneurins and FLRTs directs the migration of neurons using a contact repulsion-dependent mechanism.
Thu Jan 23 00:00:00 UTC 2020
Isolation and Glycomic Analysis of Trans-Golgi Network Vesicles in Plants.
Methods in molecular biology (Clifton, N.J.)
Ren G,Rosquete MR,Peralta AG,Pattathil S,Hahn MG,Wilkop T,Drakakaki G
A-11122 was used in Immunoprecipitation to provide a detailed description of the protocol used for the elucidation of the SYP61 vesicle population glycome.
Thu Mar 18 00:00:00 UTC 2021
Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster.
eLife
Luo Y,Fefelova E,Ninova M,Chen YA,Aravin AA
A-11122 was used in Chromatin immunoprecipitation to suggest that the SUMO pathway is responsible for both repression of interrupted units and control of intact rDNA expression.
Mon Nov 09 00:00:00 UTC 2020
Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila.
eLife
Humphries AC,Narang S,Mlodzik M
A-11122 was used in Immunohistochemistry-immunofluorescence to provide mechanistic insight into how different mammalian mutations contribute to developmental disorders and strengthen the link between PCP and NTD.
Wed Apr 01 00:00:00 UTC 2020
Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration.
eLife
Chen Y,Kotian N,Aranjuez G,Chen L,Messer CL,Burtscher A,Sawant K,Ramel D,Wang X,McDonald JA
A-11122 was used in Immunohistochemistry-immunofluorescence to study Pp1 as a major regulator of collective cohesion and migration in border cells.
Tue May 05 00:00:00 UTC 2020
Cell types and neuronal circuitry underlying female aggression in Drosophila.
eLife
Schretter CE,Aso Y,Robie AA,Dreher M,Dolan MJ,Chen N,Ito M,Yang T,Parekh R,Branson KM,Rubin GM
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal important regulatory components of the neuronal circuitry that underlies female aggressive social interactions and provides tools for their manipulation.
Tue Nov 03 00:00:00 UTC 2020
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
eLife
Marelli S,Williamson JC,Protasio AV,Naamati A,Greenwood EJ,Deane JE,Lehner PJ,Matheson NJ
A-11122 was used in Western Blotting to show that degradation of PPP2R5 family subunits is both necessary and sufficient for Vif-dependent G2/M cell cycle arrest.
Wed Apr 15 00:00:00 UTC 2020
Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux.
Molecular brain
Choi H,Kim IS,Mun JY
A-11122 was used in Immunocytochemistry to identify a link between PPA and autism phenotypes facilitated by signaling mechanisms in hippocampal neurons.
Tue Jun 02 00:00:00 UTC 2020
Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.
PLoS genetics
Sawyer JK,Kabiri Z,Montague RA,Allen SR,Stewart R,Paramore SV,Cohen E,Zaribafzadeh H,Counter CM,Fox DT
A-11122 was used in Western Blotting to screen the Drosophila genome for modifiers specific to either weak or strong Ras-driven eye phenotypes.
Tue Dec 01 00:00:00 UTC 2020
A neural circuit encoding mating states tunes defensive behavior in Drosophila.
Nature communications
Liu C,Zhang B,Zhang L,Yang T,Zhang Z,Gao Z,Zhang W
A-11122 was used in Immunocytochemistry to report that fruit flies exhibit a strong defensive response to mechanical stimuli to their wings.
Fri Aug 07 00:00:00 UTC 2020
Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila.
Cell reports
Keleş MF,Hardcastle BJ,Städele C,Xiao Q,Frye MA
A-11122 was used in Immunohistochemistry-immunofluorescence to study a highly specialized small object motion detector, LC11, and demonstrate that its responses are suppressed by local background motion.
Tue Feb 18 00:00:00 UTC 2020
Controlling motor neurons of every muscle for fly proboscis reaching.
eLife
McKellar CE,Siwanowicz I,Dickson BJ,Simpson JH
A-11122 was used in Immunohistochemistry to investigate the anatomy of all the primary motor neurons in the fly proboscis and characterise their contributions to its diverse reaching movements.
Thu Jun 25 00:00:00 UTC 2020
Cellular identity and Ca2+ signaling activity of the non-reproductive GnRH system in the Ciona intestinalis type A (Ciona robusta) larva.
Scientific reports
Okawa N,Shimai K,Ohnishi K,Ohkura M,Nakai J,Horie T,Kuhara A,Kusakabe TG
A-11122 was used in Immunocytochemistry to investigate the neuronal types of gnrh2-expressing cells in Ciona larvae and visualized the activity of these cells by fluorescence imaging using a calcium sensor protein.
Thu Oct 29 00:00:00 UTC 2020
A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility.
PLoS genetics
Li W,Liang J,Outeda P,Turner S,Wakimoto BT,Watnick T
A-11122 was used in Immunoprecipitation to identify a new complex that is involved in male fertility in Drosophila melanogaster.
Tue Dec 01 00:00:00 UTC 2020
Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.
Nature communications
Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF
A-11122 was used in Immunohistochemistry to indicate that GRP is a neuropeptide in sensory neurons for non-histaminergic itch, and GRP sensory neurons are dedicated to itch transmission.
Fri Mar 13 00:00:00 UTC 2020
Neurochemical Organization of the Drosophila Brain Visualized by Endogenously Tagged Neurotransmitter Receptors.
Cell reports
Kondo S,Takahashi T,Yamagata N,Imanishi Y,Katow H,Hiramatsu S,Lynn K,Abe A,Kumaraswamy A,Tanimoto H
A-11122 was used in Immunohistochemistry to we profile the expression of 75 neurotransmitter receptors in the brain, to reveal neurochemical segmentation.
Tue Jan 07 00:00:00 UTC 2020
Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells.
Frontiers in microbiology
Ouwendijk WJD,Dekker LJM,van den Ham HJ,Lenac Rovis T,Haefner ES,Jonjic S,Haas J,Luider TM,Verjans GMGM
A-11122 was used in Immunocytochemistry to determine the temporal changes in virus and host protein expression during productive HSV-1 and VZV infection in the same cell type.
Fri Apr 26 00:00:00 UTC 2024
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.
Nature communications
Kramarz K,Schirmeisen K,Boucherit V,Ait Saada A,Lovo C,Palancade B,Freudenreich C,Lambert SAE
A-11122 was used in Chromatin immunoprecipitation to establish a novel spatial control of Recombination-Dependent Replication (RDR) at a unique sequence that is distinct from mechanisms engaged at collapsed-forks and breaks within repeated sequences.
Fri Nov 06 00:00:00 UTC 2020
GAD2 Expression Defines a Class of Excitatory Lateral Habenula Neurons in Mice that Project to the Raphe and Pontine Tegmentum.
eNeuro
Quina LA,Walker A,Morton G,Han V,Turner EE
A-11122 was used in Immunohistochemistry to conclude that GAD2 expression can serve as a marker for functional studies of excitatory neurons serving specific LHb output pathways in mice.
Fri Jun 18 00:00:00 UTC 2021
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2.
Nature communications
Woolums BM,McCray BA,Sung H,Tabuchi M,Sullivan JM,Ruppell KT,Yang Y,Mamah C,Aisenberg WH,Saavedra-Rivera PC,Larin BS,Lau AR,Robinson DN,Xiang Y,Wu MN,Sumner CJ,Lloyd TE
A-11122 was used in Immunohistochemistry-immunofluorescence to highlight an integral role for CaMKII in neuronal TRPV4-associated Ca2+ responses, the importance of tightly regulated Ca2+ dynamics for mitochondrial axonal transport, and the therapeutic promise of TRPV4 antagonists for patients with TRPV4-related neurodegenerative diseases.
Fri May 29 00:00:00 UTC 2020
CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.
PLoS genetics
Ide T,Twan WK,Lu H,Ikawa Y,Lim LX,Henninger N,Nishimura H,Takaoka K,Narasimhan V,Yan X,Shiratori H,Roy S,Hamada H
A-11122 was used in Immunohistochemistry-immunofluorescence to establish how differential localization and function of CFAP53 contributes to the unique motion patterns of two important mammalian cilia-types.
Tue Dec 01 00:00:00 UTC 2020
Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
JCI insight
Lu PN,Moreland T,Christian CJ,Lund TC,Steet RA,Flanagan-Steet H
A-11122 was used in Immunohistochemistry to investigate the contribution of cathepsins during cardiovascular development and congenital disease.
Thu Oct 15 00:00:00 UTC 2020
A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells.
Nature communications
Sung BH,von Lersner A,Guerrero J,Krystofiak ES,Inman D,Pelletier R,Zijlstra A,Ponik SM,Weaver AM
A-11122 was used in Western Blotting to develop an improved live-cell reporter for exosome monitoring which identified pathfinding behaviour of migrating cells in both 2D and 3D.
Wed Apr 29 00:00:00 UTC 2020
Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
Cell reports
Moscato EH,Dubowy C,Walker JA,Kayser MS
A-11122 was used in Immunohistochemistry to identify a specific circuit mechanism through which Nf1 regulates social behaviors and suggest social deficits in NF1 arise from propagation of sensory misinformation.
Tue Jul 07 00:00:00 UTC 2020
Intravital three-dimensional bioprinting.
Nature biomedical engineering
Urciuolo A,Poli I,Brandolino L,Raffa P,Scattolini V,Laterza C,Giobbe GG,Zambaiti E,Selmin G,Magnussen M,Brigo L,De Coppi P,Salmaso S,Giomo M,Elvassore N
A-11122 was used in Immunohistochemistry to show that intravital 3D bioprinting of donor-muscle-derived stem cells under the epimysium of hindlimb muscle in mice leads to the de novo formation of myofibres in the mice.
Tue Sep 01 00:00:00 UTC 2020
An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility.
Science advances
Iwata S,Morikawa M,Takei Y,Hirokawa N
A-11122 was used in Western Blot, Immunocytochemistry to show that the molecular motor KIF17 is locally degraded and synthesized in an N-methyl-d-aspartate receptor (NMDAR)-mediated activity-dependent manner.
Tue Dec 01 00:00:00 UTC 2020
An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility.
Science advances
Iwata S,Morikawa M,Takei Y,Hirokawa N
A-11122 was used in Western Blot, Immunocytochemistry to show that the molecular motor KIF17 is locally degraded and synthesized in an N-methyl-d-aspartate receptor (NMDAR)-mediated activity-dependent manner.
Tue Dec 01 00:00:00 UTC 2020
Identification of a molecular basis for the juvenile sleep state.
eLife
Chakravarti Dilley L,Szuperak M,Gong NN,Williams CE,Saldana RL,Garbe DS,Syed MH,Jain R,Kayser MS
A-11122 was used in Immunohistochemistry to define the molecular cues governing sleep behavioral and circuit development, and suggest sleep disorders may be of neurodevelopmental origin.
Mon Mar 23 00:00:00 UTC 2020
Different functions of two putative Drosophila α2δ subunits in the same identified motoneurons.
Scientific reports
Heinrich L,Ryglewski S
A-11122 was used in Western Blotting to suggest that the two different putative α2δ subunits are required in the same neurons to regulate different functions of voltage gated calcium channels.
Thu Aug 13 00:00:00 UTC 2020
Coordinated hedgehog signaling induces new hair follicles in adult skin.
eLife
Sun X,Are A,Annusver K,Sivan U,Jacob T,Dalessandri T,Joost S,Füllgrabe A,Gerling M,Kasper M
A-11122 was used in Immunohistochemistry to reveal that activation of Hedgehog (Hh) signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal mouse skin.
Tue Mar 17 00:00:00 UTC 2020
Age-Dependent Activation and Neuronal Differentiation of Lgr5+ Basal Cells in Injured Olfactory Epithelium via Notch Signaling Pathway.
Frontiers in aging neuroscience
Li X,Tong M,Wang L,Qin Y,Yu H,Yu Y
A-11122 was used in Immunocytochemistry-immunofluorescence to show that activation of Lgr5+ cells in injured OE was age dependent and Notch activation could enhance the capacity of neuronal generation from Lgr5+ cells in aged OE after injury.
Tue Jan 05 00:00:00 UTC 2021
A network approach to analyze neuronal lineage and layer innervation in the Drosophila optic lobes.
PloS one
Del Valle Rodríguez A,Cera M,Portillo JR
A-11122 was used in Immunohistochemistry to establish a new methodology that helps understanding the logic of Drosophila brain development and can be applied to the more complex vertebrate brains.
Wed Apr 22 00:00:00 UTC 2020
Tetraspanin 33 (TSPAN33) regulates endocytosis and migration of human B lymphocytes by affecting the tension of the plasma membrane.
The FEBS journal
Navarro-Hernandez IC,López-Ortega O,Acevedo-Ochoa E,Cervantes-Díaz R,Romero-Ramírez S,Sosa-Hernández VA,Meza-Sánchez DE,Juárez-Vega G,Pérez-Martínez CA,Chávez-Munguía B,Galván-Hernández A,Antillón A,Ortega-Blake I,Santos-Argumedo L,Hernández-Hernández JM,Maravillas-Montero JL
A-11122 was used in Western Blotting to illustrate that TSPAN33 regulates adhesion and migration of B lymphocytes by cotrolling the mechanical properties of their plasma membrane.
Sat Aug 01 00:00:00 UTC 2020
An Interaction Network of RNA-Binding Proteins Involved in Drosophila Oogenesis.
Molecular & cellular proteomics : MCP
Bansal P,Madlung J,Schaaf K,Macek B,Bono F
A-11122 was used in Western Blotting to examine protein-protein associations of 6 GFP-tagged RBPs expressed at physiological levels, using immunoprecipitation from whole Drosophila ovaries coupled to mass spectrometry.
Tue Sep 01 00:00:00 UTC 2020
Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila.
eLife
Tiwari SK,Toshniwal AG,Mandal S,Mandal L
A-11122 was used in Immunohistochemistry to demonstrate that Fatty Acid Oxidation is essential for the differentiation of blood cell progenitors.
Fri Jun 12 00:00:00 UTC 2020
Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins.
Nature communications
Liu F,Dai S,Feng D,Qin Z,Peng X,Sakamuri SSVP,Ren M,Huang L,Cheng M,Mohammad KE,Qu P,Chen Y,Zhao C,Zhu F,Liang S,Aktas BH,Yang X,Wang H,Katakam PVG,Busija DW,Fischer T,Datta PK,Rappaport J,Gao B,Qin X
A-11122 was used in Immunocytochemistry-immunoflourescence to characterize renal macrophages at different stages in several transgenic lines.
Fri May 08 00:00:00 UTC 2020
A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
eLife
Felipe-Medina N,Caburet S,Sánchez-Sáez F,Condezo YB,de Rooij DG,Gómez-H L,Garcia-Valiente R,Todeschini AL,Duque P,Sánchez-Martin MA,Shalev SA,Llano E,Veitia RA,Pendás AM
A-11122 was used in Western Blotting to investigate the molecular mechanism of essential meiotic variant HSF2BP-S167L underlying human ovarian insufficiency and sub-fertility.
Wed Aug 26 00:00:00 UTC 2020
Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit.
Cell reports
El-Quessny M,Maanum K,Feller MB
A-11122 was used in Immunocytochemistry to indicate that different mechanisms of a cell's computational abilities can be constructed over development through divergent mechanisms.
Tue Jun 30 00:00:00 UTC 2020
Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain.
Stem cell reports
Li Q,Siri T,Bressan C,de Koninck Y,Saghatelyan A
A-11122 was used in Immunohistochemistry to reveal the developmental potential and plasticity of olfactory epithelium (OE)-derived neural stem cells (NSCs) in vivo and show that they can respond to heterotopic neurogenic cues to adapt their phenotype and become functional neurons in ectopic brain regions.
Tue Apr 14 00:00:00 UTC 2020
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.
Nature communications
Crawley-Snowdon H,Yang JC,Zaccai NR,Davis LJ,Wartosch L,Herman EK,Bright NA,Swarbrick JS,Collins BM,Jackson LP,Seaman MNJ,Luzio JP,Dacks JB,Neuhaus D,Owen DJ
A-11122 was used in Immunocytochemistry-immunoflourescence to study VARP and TBC1D5 binding the same site on VPS29 and investigate their competing for binding VPS29 in vivo.
Tue Oct 06 00:00:00 UTC 2020
OsNRAMP1 transporter contributes to cadmium and manganese uptake in rice.
Plant, cell & environment
Chang JD,Huang S,Yamaji N,Zhang W,Ma JF,Zhao FJ
A-11122 was used in Immunohistochemistry to evaluate OsNRAMP1 and its role in toxic metal uptake in yeast.
Thu Oct 01 00:00:00 UTC 2020
Lateral Hypothalamic GABAergic Neurons Encode and Potentiate Sucrose's Palatability.
Frontiers in neuroscience
Garcia A,Coss A,Luis-Islas J,Puron-Sierra L,Luna M,Villavicencio M,Gutierrez R
A-11122 was used in Immunohistochemistry to show that LHAVgat+ neurons increase the drive to consume, but this is potentiated by the palatability and proximity of the tastant.
Sat Mar 30 00:00:00 UTC 2024
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
Cell reports
Niu J,Sanders SS,Jeong HK,Holland SM,Sun Y,Collura KM,Hernandez LM,Huang H,Hayden MR,Smith GM,Hu Y,Jin Y,Thomas GM
A-11122 was used in Immunohistochemistry to demonstrate that two palmitoylation-dependent pathways mediate the control of somal and distal axon integrity.
Tue Nov 17 00:00:00 UTC 2020
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
PLoS genetics
Cross SH,Mckie L,Hurd TW,Riley S,Wills J,Barnard AR,Young F,MacLaren RE,Jackson IJ
A-11122 was used in Immunohistochemistry to show eye size is dependent on a crucial interplay between TMEM98 and MYRF.
Wed Apr 01 00:00:00 UTC 2020
Expression of the core promoter factors TATA box binding protein and TATA box binding protein-related factor 2 in Drosophila germ cells and their distinct functions in germline development.
Development, growth & differentiation
Nakamura S,Hira S,Kojima M,Kondo A,Mukai M
A-11122 was used in Immunohistochemistry to suggest that TBP-related factor 2 (Trf2) and TATA box binding protein (Tbp) expression is differentially regulated in germ cells and that these factors have distinct functions in Drosophila germline development.
Tue Dec 01 00:00:00 UTC 2020
Changes in Wnt-Dependent Neuronal Morphology Underlie the Anatomical Diversification of Neocortical Homologs in Amniotes.
Cell reports
Nomura T,Ohtaka-Maruyama C,Kiyonari H,Gotoh H,Ono K
A-11122 was used in Immunocytochemistry to study the development of the six-layered mammalian neocortex in relation to the reptilian dorsal cortex.
Tue May 05 00:00:00 UTC 2020
The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
eLife
Sanders SS,Hernandez LM,Soh H,Karnam S,Walikonis RS,Tzingounis AV,Thomas GM
A-11122 was used in Immunocytochemistry to identify the PDZ domain-containing Membrane-associated Guanylate Kinase (MaGUK) PSD93 as a direct ZDHHC14 interactor and substrate.
Fri Nov 13 00:00:00 UTC 2020
Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion.
Scientific reports
Barbaux S,Ialy-Radio C,Chalbi M,Dybal E,Homps-Legrand M,Do Cruzeiro M,Vaiman D,Wolf JP,Ziyyat A
A-11122 was used in Western Blot to propose a model in which IZUMO1 and SPACA6 would be part of a molecular complex necessary for gamete fusion and that their concomitant presence would be required for the recruitment of another essential molecular actor, such as a fusogen, for the fusion to take place.
Tue Mar 24 00:00:00 UTC 2020
Circuits that encode and guide alcohol-associated preference.
eLife
Scaplen KM,Talay M,Nunez KM,Salamon S,Waterman AG,Gang S,Song SL,Barnea G,Kaun KR
A-11122 was used in Immunohistochemistry to demonstrate that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice in Drosophila melanogaster.
Thu Jun 04 00:00:00 UTC 2020
A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex.
Cell reports
Carvalho MM,Tanke N,Kropff E,Witter MP,Moser MB,Moser EI
A-11122 was used in Immunohistochemistry to provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.
Tue Sep 08 00:00:00 UTC 2020
Expansion microscopy of C. elegans.
eLife
Yu CJ,Barry NC,Wassie AT,Sinha A,Bhattacharya A,Asano S,Zhang C,Chen F,Hobert O,Goodman MB,Haspel G,Boyden ES
A-11122 was used in Immunohistochemistry-immunofluorescence to develop methods of carrying out expansion microscopy on C. elegans (ExCel), in order to map proteins, identify new proteins and analyse gene expression.
Fri May 01 00:00:00 UTC 2020
Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.
Cell reports
Hunker AC,Soden ME,Krayushkina D,Heymann G,Awatramani R,Zweifel LS
A-11122 was used in Immunohistochemistry to reveal insight into the role of GABAergic regulation of midbrain GABA-producing neurons in psychomotor activation.
Tue Mar 24 00:00:00 UTC 2020
Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development.
Frontiers in genetics
Mo D,Chen Y,Jiang N,Shen J,Zhang J
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the roles and functional diversity of V-ATPase subunits within endocytosis, protein degradation, fluid secretion and neurotransmission using a drosophila model.
Mon Sep 28 00:00:00 UTC 2020
Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS.
eLife
Lacin H,Williamson WR,Card GM,Skeath JB,Truman JW
A-11122 was used in Immunohistochemistry-immunofluorescence to nvestigated the developmental and molecular basis of behavior by focusing on lineage-specific functions of the homeodomain transcription factor, Unc-4 in Drosophila.
Fri Mar 27 00:00:00 UTC 2020
Comparison of AAV-Mediated Optogenetic Vision Restoration between Retinal Ganglion Cell Expression and ON Bipolar Cell Targeting.
Molecular therapy. Methods & clinical development
Lu Q,Ganjawala TH,Krstevski A,Abrams GW,Pan ZH
A-11122 was used in Western Blotting to compare the restored visual functions achieved by adeno-associated virus (AAV)-mediated expression of a channelrhodopsin in ON-type bipolar cells and retinal ganglion cells driven by an improved mGluR6 promoter and a CAG promoter, respectively, in a blind mouse model by performing electrophysiological recordings and behavioral assessments.
Fri Sep 11 00:00:00 UTC 2020
dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye.
Scientific reports
Angileri KM,Gross JM
A-11122 was used in Immunohistochemistry to demonstrate that zebrafish dnmt1s872 mutants possess severe defects in RSC maintenance within the ciliary marginal zone (CMZ).
Thu Jul 09 00:00:00 UTC 2020
UNBRANCHED3 Expression and Inflorescence Development is Mediated by UNBRANCHED2 and the Distal Enhancer, KRN4, in Maize.
PLoS genetics
Du Y,Liu L,Peng Y,Li M,Li Y,Liu D,Li X,Zhang Z
A-11122 was used in Chromatin immunoprecipitation to genetically characterize the maize enhancer, kernel row number4.
Wed Apr 01 00:00:00 UTC 2020
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.
Nature
Oh Y,Lai JS,Mills HJ,Erdjument-Bromage H,Giammarinaro B,Saadipour K,Wang JG,Abu F,Neubert TA,Suh GSB
A-11122 was used in Immunohistochemistry to identify a pair of glucose-sensing neurons with bifurcated axons in the brain of Drosophila.
Tue Oct 01 00:00:00 UTC 2019
Identifying the pathways required for coping behaviours associated with sustained pain.
Nature
Huang T,Lin SH,Malewicz NM,Zhang Y,Zhang Y,Goulding M,LaMotte RH,Ma Q
A-11122 was used in Immunohistochemistry to reveals a fundamental subdivision within the cutaneous somatosensory system, and challenges the validity of using reflexive defensive responses to measure sustained pain.
Tue Jan 01 00:00:00 UTC 2019
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
Cell
Patzke C,Brockmann MM,Dai J,Gan KJ,Grauel MK,Fenske P,Liu Y,Acuna C,Rosenmund C,Südhof TC
A-11122 was used in Immunocytochemistry-immunoflourescence to characterize human and mouse synapses and reveal that neuromodulators impact synaptic transmission by altering synaptic vesicle numbers in presynaptic nerve terminals.
Thu Oct 03 00:00:00 UTC 2019
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Cell
Amezcua Vesely MC,Pallis P,Bielecki P,Low JS,Zhao J,Harman CCD,Kroehling L,Jackson R,Bailis W,Licona-Limón P,Xu H,Iijima N,Pillai PS,Kaplan DH,Weaver CT,Kluger Y,Kowalczyk MS,Iwasaki A,Pereira JP,Esplugues E,Gagliani N,Flavell RA
A-11122 was used in immunohistochemistry (frozen) immunofluorescence to delineate the origin and function of airway CD4 TRM cells during bacterial infection.
Thu Aug 22 00:00:00 UTC 2019
A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability.
Cell host & microbe
Wilke G,Funkhouser-Jones LJ,Wang Y,Ravindran S,Wang Q,Beatty WL,Baldridge MT,VanDussen KL,Shen B,Kuhlenschmidt MS,Kuhlenschmidt TB,Witola WH,Stappenbeck TS,Sibley LD
A-11122 was used in Immunohistochemistry-immunofluorescence to describe a platform for complete life cycle development and long-term growth of Cryptosporidium.
Wed Jul 10 00:00:00 UTC 2019
Divergent medial amygdala projections regulate approach-avoidance conflict behavior.
Nature neuroscience
Miller SM,Marcotulli D,Shen A,Zweifel LS
A-11122 was used in Immunohistochemistry to demonstrate divergent pathways in the MeApv that can be differentially weighted toward exploration or evasion of threats.
Mon Apr 01 00:00:00 UTC 2019
State-dependent decoupling of sensory and motor circuits underlies behavioral flexibility in Drosophila.
Nature neuroscience
Ache JM,Namiki S,Lee A,Branson K,Card GM
A-11122 was used in Immunohistochemistry to identify two descending neuron (DN) types that control landing and contribute to visuomotor flexibility in Drosophila.
Mon Jul 01 00:00:00 UTC 2019
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.
Cell stem cell
Zhou Y,Liu Z,Welch JD,Gao X,Wang L,Garbutt T,Keepers B,Ma H,Prins JF,Shen W,Liu J,Qian L
A-11122 was used in Immunocytochemistry-immunoflourescence to study the human cardiac reprogramming that utilizes an analysis pipeline and a cell fate index calculation we developed to measure reprogramming progression.
Wed Jul 03 00:00:00 UTC 2019
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.
Cell stem cell
Zhou Y,Liu Z,Welch JD,Gao X,Wang L,Garbutt T,Keepers B,Ma H,Prins JF,Shen W,Liu J,Qian L
A-11122 was used in Immunocytochemistry-immunoflourescence to study the human cardiac reprogramming that utilizes an analysis pipeline and a cell fate index calculation we developed to measure reprogramming progression.
Wed Jul 03 00:00:00 UTC 2019
Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
Cell stem cell
Hashimoto H,Wang Z,Garry GA,Malladi VS,Botten GA,Ye W,Zhou H,Osterwalder M,Dickel DE,Visel A,Liu N,Bassel-Duby R,Olson EN
A-11122 was used in Immunocytochemistry to perform genome-wide analyses of cardiogenic TF binding and enhancer profiling during cardiac reprogramming.
Wed Jul 03 00:00:00 UTC 2019
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
Cell stem cell
Kitadate Y,Jörg DJ,Tokue M,Maruyama A,Ichikawa R,Tsuchiya S,Segi-Nishida E,Nakagawa T,Uchida A,Kimura-Yoshida C,Mizuno S,Sugiyama F,Azami T,Ema M,Noda C,Kobayashi S,Matsuo I,Kanai Y,Nagasawa T,Sugimoto Y,Takahashi S,Simons BD,Yoshida S
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate, using murine spermatogenesis as a model, that spermatogenic stem cell density is tightly regulated by competition for mitogens.
Thu Jan 03 00:00:00 UTC 2019
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.
Cell stem cell
Weng Q,Wang J,Wang J,He D,Cheng Z,Zhang F,Verma R,Xu L,Dong X,Liao Y,He X,Potter A,Zhang L,Zhao C,Xin M,Zhou Q,Aronow BJ,Blackshear PJ,Rich JN,He Q,Zhou W,Suvà ML,Waclaw RR,Potter SS,Yu G,Lu QR
A-11122 was used in Immunohistochemistry-immunofluorescence to resolve the dynamic repertoire of common and divergent glial progenitors during development and tumorigenesis and highlight Zfp36l1 as a molecular nexus for balancing glial cell-fate decision and controlling gliomagenesis.
Thu May 02 00:00:00 UTC 2019
Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency.
Cell stem cell
Kalkan T,Bornelöv S,Mulas C,Diamanti E,Lohoff T,Ralser M,Middelkamp S,Lombard P,Nichols J,Smith A
A-11122 was used in Immunocytochemistry-immunoflourescence to show that genetic elimination of three complementary drivers of network transition stalls developmental progression, emulating environmental insulation by small-molecule inhibitors.
Thu May 02 00:00:00 UTC 2019
Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage.
Nucleic acids research
Kochan JA,van den Belt M,von der Lippe J,Desclos ECB,Steurer B,Hoebe RA,Scutigliani EM,Verhoeven J,Stap J,Bosch R,Rijpkema M,van Oven C,van Veen HA,Stellingwerf I,Vriend LEM,Marteijn JA,Aten JA,Krawczyk PM
A-11122 was used in Western Blotting to reveal, for the first time, the kinetics of DSB signaling triggered by X-ray microirradiation and establish XM3 as a powerful platform for real-time analysis of cellular DSB repair responses.
Thu Sep 26 00:00:00 UTC 2019
SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
Nucleic acids research
Liu H,Huang T,Li M,Li M,Zhang C,Jiang J,Yu X,Yin Y,Zhang F,Lu G,Luo MC,Zhang LR,Li J,Liu K,Chen ZJ
A-11122 was used in Immunocytochemistry-immunoflourescence to identify a novel protein, synaptonemal complex reinforcing element as a key molecule in maintaining the integrity of synaptonemal complex during meiosis prophase 1 in mice.
Thu Jun 20 00:00:00 UTC 2019
Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.
Neuron
Trusel M,Nuno-Perez A,Lecca S,Harada H,Lalive AL,Congiu M,Takemoto K,Takahashi T,Ferraguti F,Mameli M
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate foot-shock conditioning in mice to link the lateral habenula activation to avoidance learning.
Wed Apr 03 00:00:00 UTC 2019
Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.
Neuron
Phan A,Thomas CI,Chakraborty M,Berry JA,Kamasawa N,Davis RL
A-11122 was used in Immunohistochemistry to identify a new mechanism for memory suppression and to show that the size of the synaptic vesicle (SV) pool is controlled genetically and independently from other aspects of neuron structure and function through Stromalin in Drosophila.
Wed Jan 02 00:00:00 UTC 2019
Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.
Neuron
Mukai J,Cannavò E,Crabtree GW,Sun Z,Diamantopoulou A,Thakur P,Chang CY,Cai Y,Lomvardas S,Takata A,Xu B,Gogos JA
A-11122 was used in Immunohistochemistry to investigate the bind mechanisms of SETD1A.
Wed Nov 06 00:00:00 UTC 2019
Positional Strategies for Connection Specificity and Synaptic Organization in Spinal Sensory-Motor Circuits.
Neuron
Balaskas N,Abbott LF,Jessell TM,Ng D
A-11122 was used in Immunohistochemistry to propose positional strategies that could achieve sensory-motor connectivity and synaptic organisation in spinal sensory-motor circuits.
Wed Jun 19 00:00:00 UTC 2019
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila.
Neuron
Shao L,Chung P,Wong A,Siwanowicz I,Kent CF,Long X,Heberlein U
A-11122 was used in Immunohistochemistry to investigate the effect of coital sensory inputs from those of male Drosophila ejaculate.
Wed Jun 05 00:00:00 UTC 2019
Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity.
The Journal of experimental medicine
Bradley PM,Denecke CK,Aljovic A,Schmalz A,Kerschensteiner M,Bareyre FM
A-11122 was used in Immunohistochemistry to show that NMDAR signaling and CREB-mediated transcription maintain nascent corticospinal tract (CST)-relay neuron contacts.
Mon Nov 04 00:00:00 UTC 2019
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.
Brain : a journal of neurology
Rosenblad C,Li Q,Pioli EY,Dovero S,Antunes AS,Agúndez L,Bardelli M,Linden RM,Henckaerts E,Björklund A,Bezard E,Björklund T
A-11122 was used in Immunohistochemistry to provide proof-of-principle for continuous vector-mediated l-DOPA synthesis as a novel therapeutic strategy for Parkinson's disease.
Thu Aug 01 00:00:00 UTC 2019
Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans.
The Journal of allergy and clinical immunology
Progatzky F,Jha A,Wane M,Thwaites RS,Makris S,Shattock RJ,Johansson C,Openshaw PJ,Bugeon L,Hansel TT,Dallman MJ
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that respiratory challenge with R848 might offer a novel mucosal model of antiviral immunity.
Mon Jul 01 00:00:00 UTC 2019
Phosphatidylinositol 4,5-bisphosphate controls Rab7 and PLEKHM1 membrane cycling during autophagosome-lysosome fusion.
The EMBO journal
Baba T,Toth DJ,Sengupta N,Kim YJ,Balla T
A-11122 was used in Immunocytochemistry to understand the molecular mechanism that triggers Rab7 activation.
Mon Apr 15 00:00:00 UTC 2019
Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.
The EMBO journal
Oulès B,Rognoni E,Hoste E,Goss G,Fiehler R,Natsuga K,Quist S,Mentink R,Donati G,Watt FM
A-11122 was used in Immunohistochemistry to show that Gata6 is a β-catenin-independent transcriptional target of mutant Lef1.
Thu May 02 00:00:00 UTC 2019
Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements.
Developmental cell
Letizia A,He D,Astigarraga S,Colombelli J,Hatini V,Llimargas M,Treisman JE
A-11122 was used in Immunofluorescence on wholemounted tissues to suggest that Polychaetoid and Canoe link Sidekick to the actin cytoskeleton to enable tricellular adherens junctions to maintain or transmit cell bond tension during epithelial cell rearrangements.
Mon Aug 05 00:00:00 UTC 2019
Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion.
Developmental cell
Rho SS,Kobayashi I,Oguri-Nakamura E,Ando K,Fujiwara M,Kamimura N,Hirata H,Iida A,Iwai Y,Mochizuki N,Fukuhara S
A-11122 was used in Immunocytochemistry-immunoflourescence to identify the role of Rap1b in hematopoietic stem cell development in Zebrafish, by enhancing integrin-mediated cell adhesion within Notch signalling.
Mon Jun 03 00:00:00 UTC 2019
Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy.
Autophagy
Kim SW,Kim DH,Park KS,Kim MK,Park YM,Muallem S,So I,Kim HJ
A-11122 was used in Western Blotting to show that trafficking and channel function of MCOLN3/TRPML3 are regulated in the context of autophagy.
Fri Feb 01 00:00:00 UTC 2019
Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy.
Autophagy
Kim SW,Kim DH,Park KS,Kim MK,Park YM,Muallem S,So I,Kim HJ
A-11122 was used in Western Blotting to show that trafficking and channel function of MCOLN3/TRPML3 are regulated in the context of autophagy.
Fri Feb 01 00:00:00 UTC 2019
SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes.
Cancer research
Song X,Wan X,Huang T,Zeng C,Sastry N,Wu B,James CD,Horbinski C,Nakano I,Zhang W,Hu B,Cheng SY
A-11122 was used in Western Blotting to demonstrate that a major splicing factor was frequently upregulated in clinical glioma specimens and that elevated levels was associated with tumor progression and a poor prognosis for patients with glioma.
Tue Oct 15 00:00:00 UTC 2019
Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma.
Cancer research
Mastrella G,Hou M,Li M,Stoecklein VM,Zdouc N,Volmar MNM,Miletic H,Reinhard S,Herold-Mende CC,Kleber S,Eisenhut K,Gargiulo G,Synowitz M,Vescovi AL,Harter PN,Penninger JM,Wagner E,Mittelbronn M,Bjerkvig R,Hambardzumyan D,Schüller U,Tonn JC,Radke J,Glass R,Kälin RE
A-11122 was used in Immunohistochemistry to show that apelin/APLNR signaling controls GBM angiogenesis and invasion and that both pathologic features are blunted by apelin-F13A.
Wed May 01 00:00:00 UTC 2019
Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.
Proceedings of the National Academy of Sciences of the United States of America
Akil O,Dyka F,Calvet C,Emptoz A,Lahlou G,Nouaille S,Boutet de Monvel J,Hardelin JP,Hauswirth WW,Avan P,Petit C,Safieddine S,Lustig LR
A-11122 was used in Immunohistochemistry-immunofluorescence to show adeno-associated virus based gene therapy can restore hearing in mice with DFNB9-mediated congenital deafness.
Tue Mar 05 00:00:00 UTC 2019
Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke.
Proceedings of the National Academy of Sciences of the United States of America
Liang H,Zhao H,Gleichman A,Machnicki M,Telang S,Tang S,Rshtouni M,Ruddell J,Carmichael ST
A-11122 was used in Immunohistochemistry to study the mechanisms regulating poststroke neurogenesis and its functional effect.
Tue Jul 02 00:00:00 UTC 2019
The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis.
The Plant cell
Xie Z,Nolan T,Jiang H,Tang B,Zhang M,Li Z,Yin Y
A-11122 was used in Western Blotting to study the role of AP2/ERF family transcription factors in brassinosteroid-regulated growth and stress responses.
Thu Aug 01 00:00:00 UTC 2019
Chloroplasts Modulate Elongation Responses to Canopy Shade by Retrograde Pathways Involving HY5 and Abscisic Acid.
The Plant cell
Ortiz-Alcaide M,Llamas E,Gomez-Cadenas A,Nagatani A,Martínez-García JF,Rodríguez-Concepción M
A-11122 was used in Chromatin immunoprecipitation to show that the connection among chloroplast status, light (shade) signaling, and developmental responses all contribute to achieve optimal photosynthetic performance under light-changing conditions.
Fri Feb 01 00:00:00 UTC 2019
A Hybrid Approach Enabling Large-Scale Glycomic Analysis of Post-Golgi Vesicles Reveals a Transport Route for Polysaccharides.
The Plant cell
Wilkop T,Pattathil S,Ren G,Davis DJ,Bao W,Duan D,Peralta AG,Domozych DS,Hahn MG,Drakakaki G
A-11122 was used in Immunoprecipitation to provide evidence that SYP61 vesicles are involved in the transport and deposition of structural polysaccharides and glycoproteins.
Fri Mar 01 00:00:00 UTC 2019
The MCTP-SNARE Complex Regulates Florigen Transport in Arabidopsis.
The Plant cell
Liu L,Li C,Teo ZWN,Zhang B,Yu H
A-11122 was used in Immunoprecipitation to show that the plasma membrane-resident syntaxin-like glutamine-soluble N-ethylmaleimide-sensitive factor protein attachment protein receptor, SYNTAXIN OF PLANTS121, interacts with QUIRKY, a member of the family of multiple C2 domain and transmembrane region proteins, to mediate FT transport in Arabidopsis.
Tue Oct 01 00:00:00 UTC 2019
TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons.
Cell death and differentiation
Aprile D,Fruscione F,Baldassari S,Fadda M,Ferrante D,Falace A,Buhler E,Sartorelli J,Represa A,Baldelli P,Benfenati F,Zara F,Fassio A
A-11122 was used in Western Blot to investigate the impact of TBC1D24 knockdown during the first stages of neuronal differentiation when axonal specification and outgrowth take place.
Fri Nov 01 00:00:00 UTC 2019
Modality-Specific Circuits for Skylight Orientation in the Fly Visual System.
Current biology : CB
Sancer G,Kind E,Plazaola-Sasieta H,Balke J,Pham T,Hasan A,Münch LO,Courgeon M,Mathejczyk TF,Wernet MF
A-11122 was used in Immunohistochemistry to investigate the cellular and synaptic architecture in medulla columns, where linearly polarized skylight is detected for guiding orientation responses in Drosophila melanogaster.
Mon Sep 09 00:00:00 UTC 2019
Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice.
Current biology : CB
Ferretti V,Maltese F,Contarini G,Nigro M,Bonavia A,Huang H,Gigliucci V,Morelli G,Scheggia D,Managò F,Castellani G,Lefevre A,Cancedda L,Chini B,Grinevich V,Papaleo F
A-11122 was used in Immunohistochemistry to characterize the influence of endogenous OXT brain pathways on emotion discrimination in mice.
Mon Jun 17 00:00:00 UTC 2019
Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1.
Current biology : CB
Gu P,Gong J,Shang Y,Wang F,Ruppell KT,Ma Z,Sheehan AE,Freeman MR,Xiang Y
A-11122 was used in Immunohistochemistry-immunofluorescence to develop a genetic approach to generate drosophila strains with knock-in TrpA1 isoforms.
Mon Dec 02 00:00:00 UTC 2019
Gap Junction Coupling Shapes the Encoding of Light in the Developing Retina.
Current biology : CB
Caval-Holme F,Zhang Y,Feller MB
A-11122 was used in Immunohistochemistry-wholemount to show that both cell-autonomous intrinsic light responses and gap junction coupling among ipRGCs contribute to the proper encoding of light intensity in the developing retina.
Mon Dec 02 00:00:00 UTC 2019
Neural Evolution of Context-Dependent Fly Song.
Current biology : CB
Ding Y,Lillvis JL,Cande J,Berman GJ,Arthur BJ,Long X,Xu M,Dickson BJ,Stern DL
A-11122 was used in Immunohistochemistry-immunofluorescence to study the neural evolution of context-dependent fly song.
Mon Apr 01 00:00:00 UTC 2019
Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor.
PLoS biology
He Z,Luo Y,Shang X,Sun JS,Carlson JR
A-11122 was used in Immunohistochemistry-immunofluorescence to provide a molecular description of the chemosensory sensilla of a greatly understudied taste organ and define a gene that regulates the sexual circuitry of the fly.
Wed May 01 00:00:00 UTC 2019
Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking.
PLoS biology
Liu J,Zhu C,Ning G,Yang L,Cao Y,Huang S,Wang Q
A-11122 was used in Immunohistochemistry to uncover a role for Cxcr4 signaling in L-R patterning and provide fundamental insights into the molecular linkage between cell-cycle progression and ciliogenesis.
Thu Aug 01 00:00:00 UTC 2019
Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells.
PLoS biology
Ma Y,McKay DJ,Buttitta L
A-11122 was used in Immunohistochemistry-immunofluorescence to provide evidence that developmentally programmed, temporal changes in chromatin accessibility at a small subset of critical cell cycle genes act to enforce cell cycle exit during terminal differentiation in the Drosophila melanogaster wing.
Sun Sep 01 00:00:00 UTC 2019
Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration.
PLoS biology
Portela M,Venkataramani V,Fahey-Lozano N,Seco E,Losada-Perez M,Winkler F,Casas-Tintó S
A-11122 was used in Immunohistochemistry to reveal a molecular mechanism for TM production, infiltration, and maintenance that can explain both neuron-dependent tumor progression and also the neural decay associated with GB.
Sun Dec 01 00:00:00 UTC 2019
L-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy.
Science signaling
Soto D,Olivella M,Grau C,Armstrong J,Alcon C,Gasull X,Santos-Gómez A,Locubiche S,Gómez de Salazar M,García-Díaz R,Gratacòs-Batlle E,Ramos-Vicente D,Chu-Van E,Colsch B,Fernández-Dueñas V,Ciruela F,Bayés À,Sindreu C,López-Sala A,García-Cazorla À,Altafaj X
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest that l-serine supplementation might ameliorate GRIN2B-related severe encephalopathy and other neurological conditions caused by glutamatergic signaling deficiency.
Tue Jun 18 00:00:00 UTC 2019
Trehalose-6-phosphate signaling regulates thermoresponsive hypocotyl growth in Arabidopsis thaliana.
EMBO reports
Hwang G,Kim S,Cho JY,Paik I,Kim JI,Oh E
A-11122 was used in Immunocytochemistry-immunoflourescence to study the regulation of thermoresponsive growth by trehalose-6-phosphate in Arabidopsis thaliana.
Fri Oct 04 00:00:00 UTC 2019
Multiple C2 domains and transmembrane region proteins (MCTPs) tether membranes at plasmodesmata.
EMBO reports
Brault ML,Petit JD,Immel F,Nicolas WJ,Glavier M,Brocard L,Gaston A,Fouché M,Hawkins TJ,Crowet JM,Grison MS,Germain V,Rocher M,Kraner M,Alva V,Claverol S,Paterlini A,Helariutta Y,Deleu M,Lins L,Tilsner J,Bayer EM
A-11122 was used in Immunohistochemistry on frozen tissues to study the molecular mechanism and function of membrane tethering with plasmodesomata.
Thu Aug 01 00:00:00 UTC 2019
A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells.
Oncogene
Sbrissa D,Semaan L,Govindarajan B,Li Y,Caruthers NJ,Stemmer PM,Cher ML,Sethi S,Vaishampayan U,Shisheva A,Chinni SR
A-11122 was used in Western Blotting to investigate the relationship between the activity of CXCR4 and PI4KIIIα in prostate cancer cells, and identify a novel cross-talk between them.
Tue Jan 01 00:00:00 UTC 2019
Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15.
The Journal of cell biology
Malaby HLH,Dumas ME,Ohi R,Stumpff J
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that kinesin-binding protein (KBP) reduces the activity of KIF18A and KIF15 during metaphase.
Mon Apr 01 00:00:00 UTC 2019
Dynamic nanoscale morphology of the ER surveyed by STED microscopy.
The Journal of cell biology
Schroeder LK,Barentine AES,Merta H,Schweighofer S,Zhang Y,Baddeley D,Bewersdorf J,Bahmanyar S
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest the ER contains a continuum of membrane structures that includes dynamic nanoholes in sheets as well as clustered tubules.
Mon Jan 07 00:00:00 UTC 2019
The molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes.
The Journal of cell biology
Costa MFA,Ohkura H
A-11122 was used in Immunohistochemistry-immunofluorescence to provide novel insight into how oocytes maintain a bipolar spindle during metaphase arrest.
Mon Sep 02 00:00:00 UTC 2019
FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.
The Journal of cell biology
Atkins M,Gasmi L,Bercier V,Revenu C,Del Bene F,Hazan J,Fassier C
A-11122 was used in Immunocytochemistry-immunoflourescence to identify Fignl1 as a key dynein regulator required for motor circuit wiring.
Mon Oct 07 00:00:00 UTC 2019
FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.
The Journal of cell biology
Atkins M,Gasmi L,Bercier V,Revenu C,Del Bene F,Hazan J,Fassier C
A-11122 was used in Immunocytochemistry-immunoflourescence to identify Fignl1 as a key dynein regulator required for motor circuit wiring.
Mon Oct 07 00:00:00 UTC 2019
FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.
The Journal of cell biology
Atkins M,Gasmi L,Bercier V,Revenu C,Del Bene F,Hazan J,Fassier C
A-11122 was used in Immunocytochemistry-immunoflourescence to identify Fignl1 as a key dynein regulator required for motor circuit wiring.
Mon Oct 07 00:00:00 UTC 2019
ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
The Journal of cell biology
Ishida M,Bonifacino JS
A-11122 was used in Western Blotting to demonstrate that ARFRP1 is a master regulator of retrograde-carrier tethering to the TGN. The coordinated recruitment of distinct tethering factors by a bifurcated GTPase cascade may be paradigmatic of other vesicular fusion events within the cell.
Mon Nov 04 00:00:00 UTC 2019
Glucose-Regulated HLP1 Acts as a Key Molecule in Governing Thermomemory.
Plant physiology
Sharma M,Banday ZZ,Shukla BN,Laxmi A
A-11122 was used in Chromatin immunoprecipitation to reveal the novel function of Glc-regulated HLP1 in mediating thermotolerance/thermomemory response.
Sat Jun 01 00:00:00 UTC 2019
Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche.
Development (Cambridge, England)
Kaur H,Sharma SK,Mandal S,Mandal L
A-11122 was used in Immunoprecipitation to study if Lar physically associates with InR and serves as a negative regulator for insulin signaling in Drosophila larval hematopoietic niche.
Mon Dec 23 00:00:00 UTC 2019
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.
Development (Cambridge, England)
Arya R,Gyonjyan S,Harding K,Sarkissian T,Li Y,Zhou L,White K
A-11122 was used in Immunohistochemistry to show that the Cut DNA binding protein is required for neuroblast death, regulating reaper and grim downstream of the shared enhancer and of abdominal A expression.
Wed May 01 00:00:00 UTC 2019
Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage.
Development (Cambridge, England)
Grendler J,Lowgren S,Mills M,Losick VP
A-11122 was used in Immunohistochemistry to find that wound-induced polyploidization enables tissue repair when cell division is not a viable option in adult Drosophila epithelium.
Fri Aug 02 00:00:00 UTC 2019
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.
Development (Cambridge, England)
Jurynec MJ,Bai X,Bisgrove BW,Jackson H,Nechiporuk A,Palu RAS,Grunwald HA,Su YC,Hoshijima K,Yost HJ,Zon LI,Grunwald DJ
A-11122 was used in Immunohistochemistry to analyse alyron mutant embryos carrying a null mutation in paf1.
Mon Dec 16 00:00:00 UTC 2019
E2FA and E2FB transcription factors coordinate cell proliferation with seed maturation.
Development (Cambridge, England)
Leviczky T,Molnár E,Papdi C,Őszi E,Horváth GV,Vizler C,Nagy V,Pauk J,Bögre L,Magyar Z
A-11122 was used in Chromatin immunoprecipitation to reveal a repressor function of the activator E2Fs to restrict the seed maturation programme until the cell proliferation phase is completed.
Tue Nov 26 00:00:00 UTC 2019
H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration.
Development (Cambridge, England)
Ben-Yair R,Butty VL,Busby M,Qiu Y,Levine SS,Goren A,Boyer LA,Burns CG,Burns CE
A-11122 was used in Immunohistochemistry-immunofluorescence to identify H3K27me3-mediated silencing of structural genes as requisite for zebrafish heart regeneration and suggests that repression of similar structural components in the border zone of an infarcted human heart might improve its regenerative capacity.
Wed Oct 09 00:00:00 UTC 2019
PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.
Development (Cambridge, England)
Prajapati RS,Hintze M,Streit A
A-11122 was used in Immunocytochemistry to identify the role of the transcription factor PRDM1 in ectodermal cell fate allocation during early embryogenesis.
Mon Dec 16 00:00:00 UTC 2019
Smooth muscle differentiation shapes domain branches during mouse lung development.
Development (Cambridge, England)
Goodwin K,Mao S,Guyomar T,Miller E,Radisky DC,Košmrlj A,Nelson CM
A-11122 was used in Immunohistochemistry-immunofluorescence to shed light on the physical mechanisms of branching morphogenesis in the mouse lung.
Mon Nov 25 00:00:00 UTC 2019
Topography of Reward and Aversion Encoding in the Mesolimbic Dopaminergic System.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yuan L,Dou YN,Sun YG
A-11122 was used in Immunohistochemistry to extend our knowledge about how the mesolimbic DA system process motivational information at the circuitry level.
Wed Aug 14 00:00:00 UTC 2019
AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Li XY,Han Y,Zhang W,Wang SR,Wei YC,Li SS,Lin JK,Yan JJ,Chen AX,Zhang X,Zhao ZD,Shen WL,Xu XH
A-11122 was used in Immunohistochemistry to discover that activation of AGRP→mPOA projections in female mice inhibits maternal nest-building but pup retrieval behaviour is mostly similar is mostly unchanged.
Wed Jan 16 00:00:00 UTC 2019
Chemogenetic Inhibition Reveals That Processing Relative But Not Absolute Threat Requires Basal Amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Campese VD,Kim IT,Hou M,Gupta S,Draus C,Kurpas B,Burke K,LeDoux JE
A-11122 was used in Immunohistochemistry-immunofluorescence to study the role of basal amygdala in discriminating between different aversive stimuli and the appropriate response to them.
Wed Oct 23 00:00:00 UTC 2019
A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sanders KM,Sakai K,Henry TD,Hashimoto T,Akiyama T
A-11122 was used in Immunohistochemistry to show activation of histamine-responsive amygdala neurons enhanced scratching indicating an importance in the itch-response.
Wed Apr 24 00:00:00 UTC 2019
The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bernardi RE,Olevska A,Morella I,Fasano S,Santos E,Brambilla R,Spanagel R
A-11122 was used in Immunohistochemistry to study Ras-ERK signalling and its upstream regulators in drug taking behaviour.
Wed Aug 07 00:00:00 UTC 2019
Functional Coordination of the Chromatin-Remodeling Factor AtINO80 and the Histone Chaperones NRP1/2 in Inflorescence Meristem and Root Apical Meristem.
Frontiers in plant science
Kang H,Ma J,Wu D,Shen WH,Zhu Y
A-11122 was used in Chromatin immunoprecipitation to provide novel insight into the functional coordination of the two epigenetic factors AtINO80 and NRP1/2 in apical meristems during plant growth and development.
Tue Sep 29 00:00:00 UTC 2020
Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang B,Pan JX,Yu H,Xiong L,Zhao K,Xiong S,Guo JP,Lin S,Sun D,Zhao L,Guo H,Mei L,Xiong WC
A-11122 was used in Immunocytochemistry-Immunofluorescence to study the effects of Myo10 loss of function on osteoporotic regulation in mice models.
Wed May 01 00:00:00 UTC 2019
High-Affinity DARPin Allows Targeting of MeV to Glioblastoma Multiforme in Combination with Protease Targeting without Loss of Potency.
Molecular therapy oncolytics
Hanauer JRH,Koch V,Lauer UM,Mühlebach MD
A-11122 was used in Western Blotting to generate a receptor-targeted MeV by using receptor-blind viral attachment protein genetically fused to designed ankyrin repeat protein (DARPin) binding domains specific for the epidermal growth factor receptor (EGFR).
Fri Dec 20 00:00:00 UTC 2019
Peripheral Delta Opioid Receptors Mediate Formoterol Anti-allodynic Effect in a Mouse Model of Neuropathic Pain.
Frontiers in molecular neuroscience
Ceredig RA,Pierre F,Doridot S,Alduntzin U,Hener P,Salvat E,Yalcin I,Gaveriaux-Ruff C,Barrot M,Massotte D
A-11122 was used in Immunohistochemistry to confirm that changes in the mechanical threshold are associated with changes in peripheral DOP profile and to highlight the common impact on DOP receptors between serotonin noradrenaline reuptake inhibitors such as duloxetine and the β2 mimetic formoterol.
Mon Sep 28 00:00:00 UTC 2020
NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice.
Frontiers in molecular neuroscience
Ratai O,Hermainski J,Ravichandran K,Pongs O
A-11122 was used in Immunohistochemistry to show that NCS-1 plays an important role in adipocyte function and that NCS-1 deficiency gives rise to obesity and diabetes type 2 in adult mice.
Tue Sep 29 00:00:00 UTC 2020
ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fuqua JD,Mere CP,Kronemberger A,Blomme J,Bae D,Turner KD,Harris MP,Scudese E,Edwards M,Ebert SM,de Sousa LGO,Bodine SC,Yang L,Adams CM,Lira VA
A-11122 was used in Immunohistochemistry to reveal unc-51 like autophagy activating kinase (ULK)2 to be an essential protein for degradation of ubiquitinated proteins and homeostasis in skeletal muscle.
Fri Nov 01 00:00:00 UTC 2019
Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Xu Y,Huang L,Kirschman JL,Vanover DA,Tiwari PM,Santangelo PJ,Shen X,Russell DG
A-11122 was used in Immunohistochemistry to demonstrate how IVT strategies can be combined to recruit and reprogram immune effector cells that have the capacity to fulfill complex biological tasks in vivo.
Tue Jan 15 00:00:00 UTC 2019
Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway.
Journal of cell science
Neumann A,Schindler M,Olofsson D,Wilhelmi I,Schürmann A,Heyd F
A-11122 was used in Blocking experiments to identify over 200 alternative splicing events as secretion regulators.
Thu Apr 25 00:00:00 UTC 2019
An autism-associated mutation in GluN2B prevents NMDA receptor trafficking and interferes with dendrite growth.
Journal of cell science
Sceniak MP,Fedder KN,Wang Q,Droubi S,Babcock K,Patwardhan S,Wright-Zornes J,Pham L,Sabo SL
A-11122 was used in Immunocytochemistry to investigate cellular phenotypes induced by a human mutation that is predicted to truncate GluN2B within the extracellular loop.
Fri Oct 18 00:00:00 UTC 2019
GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73.
Journal of cell science
Lalioti ME,Arbi M,Loukas I,Kaplani K,Kalogeropoulou A,Lokka G,Kyrousi C,Mizi A,Georgomanolis T,Josipovic N,Gkikas D,Benes V,Politis PK,Papantonis A,Lygerou Z,Taraviras S
A-11122 was used in Western Blot to highlight novel signaling cues involved in the commitment program of MCCs across species and tissues.
Mon Jun 03 00:00:00 UTC 2019
Prx1-Expressing Progenitor Primary Cilia Mediate Bone Formation in response to Mechanical Loading in Mice.
Stem cells international
Moore ER,Chen JC,Jacobs CR
A-11122 was used in Immunohistochemistry to show that Prx1-expressing cells become embedded osteocytes in response to physical loading and this mechanism requires the primary cilium.
Mon Apr 22 00:00:00 UTC 2024
Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Human molecular genetics
Reilly ML,Stokman MF,Magry V,Jeanpierre C,Alves M,Paydar M,Hellinga J,Delous M,Pouly D,Failler M,Martinovic J,Loeuillet L,Leroy B,Tantau J,Roume J,Gregory-Evans CY,Shan X,Filges I,Allingham JS,Kwok BH,Saunier S,Giles RH,Benmerah A
A-11122 was used in Western Blot to show severe syndrome associating microcephaly and renal hypodysplasia can be triggered by mutations in mitotic kinesin KIF14.
Fri Mar 01 00:00:00 UTC 2019
Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.
Human molecular genetics
Dupont MA,Humbert C,Huber C,Siour Q,Guerrera IC,Jung V,Christensen A,Pouliet A,Garfa-Traoré M,Nitschké P,Injeyan M,Millar K,Chitayat D,Shannon P,Girisha KM,Shukla A,Mechler C,Lorentzen E,Benmerah A,Cormier-Daire V,Jeanpierre C,Saunier S,Delous M
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate if short-rib thoracic dysplasia-associated missense mutation impairs intraflagellar transport-B (IFT) complex assembly and IFT-B2 ciliary localization, resulting in decreased cilia length.
Thu Aug 15 00:00:00 UTC 2019
A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.
Human molecular genetics
Gershlick DC,Ishida M,Jones JR,Bellomo A,Bonifacino JS,Everman DB
A-11122 was used in Western Blotting to study role of GARP/EARP complexes in cellular and organismal physiology and how this relates to neurodevelopmental disorders.
Wed May 01 00:00:00 UTC 2019
Vascular Endothelial Growth Factor Delivery to Placental Basal Plate Promotes Uterine Artery Remodeling in the Primate.
Endocrinology
Babischkin JS,Aberdeen GW,Lindner JR,Bonagura TW,Pepe GJ,Albrecht ED
A-11122 was used in Immunocytochemistry-immunoflourescence to establish the role of extravillous trophoblast vascular endothelial growth factor in elevating estradiol levels and regulating uterine artery remodeling, promoting placental blood flow in early baboon pregnancy.
Sat Jun 01 00:00:00 UTC 2019
GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.
Cerebral cortex (New York, N.Y. : 1991)
Aceto G,Re A,Mattera A,Leone L,Colussi C,Rinaudo M,Scala F,Gironi K,Barbati SA,Fusco S,Green T,Laezza F,D'Ascenzo M,Grassi C
A-11122 was used in Immunoprecipitation to identify the functional interaction between GSK3β and Kv4.2 channel as a novel mechanism for tLTD modulation.
Wed May 01 00:00:00 UTC 2019
Split-QF System for Fine-Tuned Transgene Expression in Drosophila.
Genetics
Riabinina O,Vernon SW,Dickson BJ,Baines RA
A-11122 was used in Immunohistochemistry-immunofluorescence to report the development and demonstrate the applications of a split-QF system that drives strong expression in Drosophila, is repressible by QS and is inducible by a small nontoxic molecule.
Wed May 01 00:00:00 UTC 2019
Renal Na+ excretion consequent to pharmacogenetic activation of Gq-DREADD in principal cells.
American journal of physiology. Renal physiology
Mironova E,Suliman F,Stockand JD
A-11122 was used in Immunohistochemistry to demonstrate that selective activation of the P2Y2 receptor and Gq signaling in principal cells is sufficient to promote renal salt excretion.
Mon Apr 01 00:00:00 UTC 2019
Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin.
Molecular pharmacology
Gibson ES,Woolfrey KM,Li H,Hogan PG,Nemenoff RA,Heasley LE,Dell'Acqua ML
A-11122 was used in Immunoprecipitation to identify the docking of CaN to the γ isoform of MKK7, a component of the c-Jun N-terminal kinase (JNK) pathway, to regulate it's subcellular localisation and activity.
Tue Jan 01 00:00:00 UTC 2019
Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin.
Molecular pharmacology
Gibson ES,Woolfrey KM,Li H,Hogan PG,Nemenoff RA,Heasley LE,Dell'Acqua ML
A-11122 was used in Immunoprecipitation to identify the docking of CaN to the γ isoform of MKK7, a component of the c-Jun N-terminal kinase (JNK) pathway, to regulate it's subcellular localisation and activity.
Tue Jan 01 00:00:00 UTC 2019
Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels.
The Journal of general physiology
Zawieja SD,Castorena JA,Gui P,Li M,Bulley SA,Jaggar JH,Rock JR,Davis MJ
A-11122 was used in Immunocytochemistry-immunoflourescence to show that the canonical CaCC Anoctamin 1 (Ano1, TMEM16a) plays an important role in lymphatic smooth muscle pacemaking.
Mon Apr 01 00:00:00 UTC 2019
Ventrolateral periaqueductal gray mediates rapid eye movement sleep regulation by melanin-concentrating hormone neurons.
Neuroscience
Kroeger D,Bandaru SS,Madara JC,Vetrivelan R
A-11122 was used in Immunohistochemistry to show rapid eye movement sleep may be modulated through an essential relay provided by the ventrolateral periaqueductal gray and the lateral pontine tegmentum (vlPAG/LPT).
Wed May 15 00:00:00 UTC 2019
Neuronal Activity in Non-LNv Clock Cells Is Required to Produce Free-Running Rest:Activity Rhythms in Drosophila.
Journal of biological rhythms
Bulthuis N,Spontak KR,Kleeman B,Cavanaugh DJ
A-11122 was used in Immunohistochemistry to report the discovery of Mortaparib as a dual inhibitor of mortalin and PARP1 and identify as a potential anticancer drug due to its tumor suppressor activity.
Sat Jun 01 00:00:00 UTC 2019
Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells.
Virology
Staubus AO,Alfadhli A,Barklis RL,Barklis E
A-11122 was used in Immunocytochemistry-immunoflourescence to study how cytoplasmic tails (CT) elements regulate HIV-1 envelope (Env) protein function.
Sun Dec 01 00:00:00 UTC 2019
KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells.
Molecular medicine reports
Patankar M,Eskelinen S,Tuomisto A,Mäkinen MJ,Karttunen TJ
A-11122 was used in Western Blotting to demonstrate that KRAS and BRAF mutations induce anoikis resistance in colon cancer cells.
Fri Nov 01 00:00:00 UTC 2019
Cellular Dynamics during Spinal Cord Regeneration in Larval Zebrafish.
Developmental neuroscience
Anguita-Salinas C,Sánchez M,Morales RA,Ceci ML,Rojas-Benítez D,Allende ML
A-11122 was used in Immunohistochemistry to show that severed spinal axons exhibited varying regenerative capabilities and plasticity depending on their original dorsoventral position in the spinal cord.
Mon Mar 30 00:00:00 UTC 2020
AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF.
Journal of the Association for Research in Otolaryngology : JARO
Leake PA,Rebscher SJ,Dore' C,Akil O
A-11122 was used in Immunocytochemistry-immunoflourescence to investigate the potential of adeno-associated viral vectors to elicit targeted neurotrophic factor expression in the cochlea and promote improved spiral ganglion and radial nerve fiber survival.
Thu Aug 01 00:00:00 UTC 2019
Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development.
Developmental biology
Ganz J,Melancon E,Wilson C,Amores A,Batzel P,Strader M,Braasch I,Diba P,Kuhlman JA,Postlethwait JH,Eisen JS
A-11122 was used in Immunohistochemistry-immunofluorescence to find that functional loss of a DNA methylation machinery component, ubiquitin-like protein containing PHD and RING finger domain 1, leads to reduced numbers of ectoderm-derived enteric neurons and severe disruption of mesoderm-derived intestinal smooth muscle.
Fri Nov 15 00:00:00 UTC 2019
Structure-function analysis of β-arrestin Kurtz reveals a critical role of receptor interactions in downregulation of GPCR signaling in vivo.
Developmental biology
Chai F,Xu W,Musoke T,Tarabelsi G,Assaad S,Freedman J,Peterson R,Piotrowska K,Byrnes J,Rogers S,Veraksa A
A-11122 was used in Immunocytochemistry-immunoflourescence to analyse the in vivo structure and function of Kurtz within the drosophila.
Fri Nov 15 00:00:00 UTC 2019
Decoupling developmental apoptosis and neuroblast proliferation in Drosophila.
Developmental biology
Harding K,White K
A-11122 was used in Immunohistochemistry to demonstrate that upstream control of neuroblast proliferation and apoptosis represent independent mechanisms of regulating stem cell fate, and that execution of apoptosis occurs in a cell cycle-independent manner.
Sun Dec 01 00:00:00 UTC 2019
The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.
Developmental biology
Ratcliffe LE,Asiedu EK,Pickett CJ,Warburton MA,Izzi SA,Meedel TH
A-11122 was used in Immunohistochemistry-immunofluorescence to indicate that ascidians have previously unrecognized and potentially novel requirements for MRF-directed myogenesis.
Mon Apr 15 00:00:00 UTC 2019
Avian Adeno-Associated Viral Transduction of the Postembryonic Chicken Retina.
Translational vision science & technology
Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK
A-11122 was used in Immunohistochemistry to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina.
Mon Jul 01 00:00:00 UTC 2019
Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid.
Developmental dynamics : an official publication of the American Association of Anatomists
Hernandez L,Ryckebüsch L,Wang C,Ling R,Yelon D
A-11122 was used in Western Blot to support a model in which HA degradation, regulated by Tmem2, limits the distribution of Wnt signaling and thereby confines the differentiation of the AVC.
Sun Dec 01 00:00:00 UTC 2019
Zebrafish model of KRAS-initiated pancreatic endocrine tumor.
Animal cells and systems
Oh S,Park JT
A-11122 was used in Immunohistochemistry to establish a zebrafish model as a suitable experimental system with which to assess the effectiveness of strategies for targeting pancreatic endocrine tumours.
Sat Jun 01 00:00:00 UTC 2019
Optogenetic inhibition of the medial prefrontal cortex reduces methamphetamine-primed reinstatement in male and female rats.
Behavioural pharmacology
Cordie R,McFadden LM
A-11122 was used in Immunohistochemistry to investigate if the prelimbic portion of the mPFC plays a role in methamphetamine-seeking behaviour using rat models.
Sun Sep 01 00:00:00 UTC 2019
Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jeong S,Ko J,Kim M,Park KC,Park EYJ,Kim J,Baik Y,Wie J,Cho AE,Jeon JH,So I
A-11122 was used in Western Blotting to suggest that although other pore residues are not critical, they could partly contribute to the EA-induced channel activation.
Wed May 01 00:00:00 UTC 2019
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.
Stem cell research
Überbacher C,Obergasteiger J,Volta M,Venezia S,Müller S,Pesce I,Pizzi S,Lamonaca G,Picard A,Cattelan G,Malpeli G,Zoli M,Beccano-Kelly D,Flynn R,Wade-Martins R,Pramstaller PP,Hicks AA,Cowley SA,Corti C
A-11122 was used in Immunocytochemistry-immunoflourescence to generate a model to investigate the system for dopaminergic neurones in Parkinson's.
Sun Dec 01 00:00:00 UTC 2019
Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.
Frontiers in immunology
Coronado M,Solis CJ,Hernandez PP,Feijóo CG
A-11122 was used in Immunohistochemistry to develop and assess the effectiveness of a novel anti-CD38 antibody, SG003, against CD38-related cancers.
Wed Jul 08 00:00:00 UTC 2020
The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.
PLoS genetics
Hill AS,Jain P,Folan NE,Ben-Shahar Y
A-11122 was used in Immunohistochemistry-immunofluorescence to show the Drosophila voltage-gated potassium channel seizure contributes to neuronal homeostasis, robustness, and stress resistance.
Thu Aug 01 00:00:00 UTC 2019
A regulatory role of autophagy for resetting the memory of heat stress in plants.
Plant, cell & environment
Sedaghatmehr M,Thirumalaikumar VP,Kamranfar I,Marmagne A,Masclaux-Daubresse C,Balazadeh S
A-11122 was used in Western Blotting to reveal a novel regulatory mechanism for heat stress memory in plants.
Fri Mar 01 00:00:00 UTC 2019
Stereotyped Combination of Hearing and Wind/Gravity-Sensing Neurons in the Johnston's Organ of Drosophila.
Frontiers in physiology
Ishikawa Y,Fujiwara M,Wong J,Ura A,Kamikouchi A
A-11122 was used in Immunohistochemistry to show that Johnston's organ neurons are grouped in stereotypical combinations each with a distinct response property in a scolopidium.
Wed Sep 30 00:00:00 UTC 2020
Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep.
Nature communications
Gutierrez Herrera C,Girard F,Bilella A,Gent TC,Roccaro-Waldmeyer DM,Adamantidis A,Celio MR
A-11122 was used in Immunohistochemistry to provide the first evidence for a brainstem premotor command contributing to the control of eye movements selectively during REM sleep in the mammalian brain.
Tue Nov 19 00:00:00 UTC 2019
OsCASP1 Is Required for Casparian Strip Formation at Endodermal Cells of Rice Roots for Selective Uptake of Mineral Elements.
The Plant cell
Wang Z,Yamaji N,Huang S,Zhang X,Shi M,Fu S,Yang G,Ma JF,Xia J
A-11122 was used in Immunohistochemistry to indicate that OsCASP1 (Casparian strip domain protein 1) is required for Casparian strip (CS) formation at the endodermis and that the CS in rice plays an important role in root selective uptake of mineral elements, especially Ca and Si.
Fri Nov 01 00:00:00 UTC 2019
Direct visualization of a molecular handshake that governs kin recognition and tissue formation in myxobacteria.
Nature communications
Cao P,Wall D
A-11122 was used in Western Blotting to study how microbes use a fluid outer membrane receptor to recognize and assemble kin cells into a cooperative multicellular community that resembles a tissue.
Fri Jul 12 00:00:00 UTC 2019
Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster.
PloS one
Ng CL,Qian Y,Schulz C
A-11122 was used in Immunohistochemistry-immunofluorescence to show that Notch and Delta are essential for germline stem cell lineage survival in Drosophila melanogaster.
Fri Mar 06 00:00:00 UTC 2020
Interspecies conservation of organisation and function between nonhomologous regional centromeres.
Nature communications
Tong P,Pidoux AL,Toda NRT,Ard R,Berger H,Shukla M,Torres-Garcia J,Müller CA,Nieduszynski CA,Allshire RC
A-11122 was used in Immunocytochemistry-immunoflourescence to show that despite the lack of sequence conservation, Schizosaccharomyces centromere DNA possesses intrinsic conserved properties that promote assembly of CENP-A chromatin.
Tue May 28 00:00:00 UTC 2019
Cigarette smoke extracts and cadmium induce COX-2 expression through γ-secretase-mediated p38 MAPK activation in C6 astroglia cells.
PloS one
Lim HJ,Park JH,Jo C,Yoon K,Koh YH
A-11122 was used in Western Blotting to investigate the signaling cascade activated by cigarette smoke extracts (CSE) and cadmium (Cd) resulting in the COX-2 induction in C6 rat astroglia cells.
Thu Nov 21 00:00:00 UTC 2019
Iterative and Complex Asymmetric Divisions Control Cell Volume Differences in Ciona Notochord Tapering.
Current biology : CB
Winkley K,Ward S,Reeves W,Veeman M
A-11122 was used in Immunohistochemistry to demonstrate a new role for asymmetric division in directly shaping a developing organ and point toward complex underlying mechanisms.
Mon Oct 21 00:00:00 UTC 2019
Enterovirus pathogenesis requires the host methyltransferase SETD3.
Nature microbiology
Diep J,Ooi YS,Wilkinson AW,Peters CE,Foy E,Johnson JR,Zengel J,Ding S,Weng KF,Laufman O,Jang G,Xu J,Young T,Verschueren E,Kobluk KJ,Elias JE,Sarnow P,Greenberg HB,Hüttenhain R,Nagamine CM,Andino R,Krogan NJ,Gozani O,Carette JE
A-11122 was used in Immunocytochemistry-immunoflourescence to study how Enteroviruses (EVs) co-opt cellular functions to promote replication and spread.
Sun Dec 01 00:00:00 UTC 2019
Tumorigenic effects of TLX overexpression in HEK 293T cells.
Cancer reports (Hoboken, N.J.)
Parris TZ,Vizlin-Hodzic D,Salmela S,Funa K
A-11122 was used in Immunocytochemistry to illustrate that TLX may play a role in tumorigenesis via genomic instability and perturbation of cancer-related processes.
Tue Oct 01 00:00:00 UTC 2019
The yellow gene influences Drosophila male mating success through sex comb melanization.
eLife
Massey JH,Chung D,Siwanowicz I,Stern DL,Wittkopp PJ
A-11122 was used in Immunohistochemistry to show that the yellow gene in Drosophila melanogaster males effects pigmentation of sex combs and in turn mating success.
Tue Oct 15 00:00:00 UTC 2019
MAP4K4 associates with BIK1 to regulate plant innate immunity.
EMBO reports
Jiang Y,Han B,Zhang H,Mariappan KG,Bigeard J,Colcombet J,Hirt H
A-11122 was used in Western Blot to define Pin1 as a novel modulator of Ca2+ handling, with implications for improving myocardial contractility and potential for ameliorating development of heart failure.
Tue Nov 05 00:00:00 UTC 2019
Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.
Frontiers in cellular neuroscience
Martínez-Frailes C,Di Lauro C,Bianchi C,de Diego-García L,Sebastián-Serrano Á,Boscá L,Díaz-Hernández M
A-11122 was used in Immunohistochemistry-immunofluorescence to evaluate whether the P2X7R age related-changes on microglia cells may be relevant to the alzheimer disease (AD) progression, by generating a new transgenic mouse model crossing an AΒ peptide mouse model, J20 mice and the P2X7R reporter mice P2X7REGFP.
Thu Oct 01 00:00:00 UTC 2020
Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice.
Cancers
Re Cecconi AD,Forti M,Chiappa M,Zhu Z,Zingman LV,Cervo L,Beltrame L,Marchini S,Piccirillo R
A-11122 was used in Western Blotting to identify a myokine regulated by PGC1α and/or aerobic exercise, with possible therapeutic action, that could hopefully be confirmed in cancer patients who are not able to do regular physical activity.
Sat Oct 12 00:00:00 UTC 2019
Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors.
Neural development
Wojcinski A,Morabito M,Lawton AK,Stephen DN,Joyner AL
A-11122 was used in Immunohistochemistry to suggest that the ability of the neonatal cerebellum to regenerate after loss of cells via a response by NEPs must therefore be considered when interpreting the phenotypes of Atoh1-Cre conditional mutants affecting GCPs.
Thu Feb 14 00:00:00 UTC 2019
Midbrain tectal stem cells display diverse regenerative capacities in zebrafish.
Scientific reports
Lindsey BW,Aitken GE,Tang JK,Khabooshan M,Douek AM,Vandestadt C,Kaslin J
A-11122 was used in Immunohistochemistry to assess the function of quiescent RG (qRG) during regeneration by performing a stab lesion in the adult midbrain tectum to target a population of homeostatic qRG, and to investigate their proliferative behaviour, differentiation potential, and Wnt/Β-catenin signalling.
Thu Mar 14 00:00:00 UTC 2019
Targeted sequencing of DCSTAMP in familial Paget's disease of bone.
Bone reports
Sultana MA,Pavlos NJ,Ward L,Walsh JP,Rea SL
A-11122 was used in Western Blotting to conclude that genetic variation in DCSTAMP is not a significant predisposing factor in our specific cohort of PDB patients and the p.L397F variant is unlikely to be a contributing factor in PDB pathogenesis.
Sat Jun 01 00:00:00 UTC 2019
Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord.
Cell reports
Gorla M,Santiago C,Chaudhari K,Layman AAK,Oliver PM,Bashaw GJ
A-11122 was used in Immunohistochemistry to define a key role for the Ndfip adaptor proteins in preventing the surface expression of the Robo1 receptor prior to midline crossing.
Tue Mar 19 00:00:00 UTC 2019
Histone deposition promotes recombination-dependent replication at arrested forks.
PLoS genetics
Hardy J,Dai D,Ait Saada A,Teixeira-Silva A,Dupoiron L,Mojallali F,Fréon K,Ochsenbein F,Hartmann B,Lambert S
A-11122 was used in Immunoprecipitation to show recombination-dependent-replication is promoted by histone deposition.
Tue Oct 01 00:00:00 UTC 2019
Histone deposition promotes recombination-dependent replication at arrested forks.
PLoS genetics
Hardy J,Dai D,Ait Saada A,Teixeira-Silva A,Dupoiron L,Mojallali F,Fréon K,Ochsenbein F,Hartmann B,Lambert S
A-11122 was used in Immunoprecipitation to show recombination-dependent-replication is promoted by histone deposition.
Tue Oct 01 00:00:00 UTC 2019
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing.
Molecules (Basel, Switzerland)
Végh AMD,den Haan AD,Cócera Ortega L,Verkerk AO,Sluijter JPG,Bakker D,van Amersfoorth S,van Veen TAB,Klerk M,Seppen J,de Bakker JMT,Christoffels VM,Geerts D,Goumans MJTH,Tan HL,Boink GJJ
A-11122 was used in Immunocytochemistry-immunoflourescence to show that cardiomyocyte progenitor cells expressing HCN4-GFP functionally couple to neonatal rat ventricular myocytes and induce physiologically controlled pacemaker activity.
Sat Jan 05 00:00:00 UTC 2019
Retrograde Ret signaling controls sensory pioneer axon outgrowth.
eLife
Tuttle A,Drerup CM,Marra M,McGraw H,Nechiporuk AV
A-11122 was used in Immunohistochemistry to show a specific role for Ret51 in pioneer axon growth, and suggest a critical role for long-range retrograde Ret signaling in regulating growth cone dynamics through downstream transcriptional changes.
Mon Sep 02 00:00:00 UTC 2019
E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family.
Nature communications
Hsu J,Arand J,Chaikovsky A,Mooney NA,Demeter J,Brison CM,Oliverio R,Vogel H,Rubin SM,Jackson PK,Sage J
A-11122 was used in Western Blotting to show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells.
Wed Jul 03 00:00:00 UTC 2019
Investigation of the Developmental Requirements of Drosophila HP1 and Insulator Protein Partner, HIPP1.
G3 (Bethesda, Md.)
Glenn SE,Geyer PK
A-11122 was used in Immunohistochemistry to show that HIPP1 is a widely expressed nuclear protein that is dispensable for viability, as well as female and male fertility.
Thu Feb 07 00:00:00 UTC 2019
Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability.
eLife
Weiss S,Melom JE,Ormerod KG,Zhang YV,Littleton JT
A-11122 was used in Western Blotting to show that elevation of glial Ca2+ causes hyperactivation of calcineurin-dependent endocytosis and accumulation of early endosomes.
Fri Apr 26 00:00:00 UTC 2019
Mild Inactivation of RE-1 Silencing Transcription Factor (REST) Reduces Susceptibility to Kainic Acid-Induced Seizures.
Frontiers in cellular neuroscience
Carminati E,Buffolo F,Rocchi A,Michetti C,Cesca F,Benfenati F
A-11122 was used in Immunocytochemistry to study the impact of REST modulation on seizure propensity ,and developed a tool for its negative modulation in vivo.
Mon Sep 28 00:00:00 UTC 2020
Mild Inactivation of RE-1 Silencing Transcription Factor (REST) Reduces Susceptibility to Kainic Acid-Induced Seizures.
Frontiers in cellular neuroscience
Carminati E,Buffolo F,Rocchi A,Michetti C,Cesca F,Benfenati F
A-11122 was used in Immunocytochemistry to study the impact of REST modulation on seizure propensity ,and developed a tool for its negative modulation in vivo.
Mon Sep 28 00:00:00 UTC 2020
Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat.
Gene therapy
Dias MS,Araujo VG,Vasconcelos T,Li Q,Hauswirth WW,Linden R,Petrs-Silva H
A-11122 was used in Immunohistochemistry to report that they were not effective.
Sun Dec 01 00:00:00 UTC 2019
A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis.
The EMBO journal
Lin F,Krishnamoorthy P,Schubert V,Hause G,Heilmann M,Heilmann I
A-11122 was used in Immunohistochemistry to propose that PI4Kβ and MPK4 influence localization and activity of MAP65-3, respectively, acting synergistically to control phragmoplast dynamics.
Fri Feb 15 00:00:00 UTC 2019
CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells.
Science advances
Min YL,Li H,Rodriguez-Caycedo C,Mireault AA,Huang J,Shelton JM,McAnally JR,Amoasii L,Mammen PPA,Bassel-Duby R,Olson EN
A-11122 was used in Western Blotting to correct the mutations that delete exon 33 in dystrophin gene in mouse and human cells that eventually cause development of Duchenne muscular dystrophy.
Fri Mar 01 00:00:00 UTC 2019
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Nature communications
Miklas JW,Clark E,Levy S,Detraux D,Leonard A,Beussman K,Showalter MR,Smith AT,Hofsteen P,Yang X,Macadangdang J,Manninen T,Raftery D,Madan A,Suomalainen A,Kim DH,Murry CE,Fiehn O,Sniadecki NJ,Wang Y,Ruohola-Baker H
A-11122 was used in Immunocytochemistry-immunoflourescence to reveal that HADHA is requited for fatty acid beta-oxidation and cardiolipin remodelling, essential for functional mitochondria in human cardiomyocytes.
Fri Oct 11 00:00:00 UTC 2019
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Nature communications
Miklas JW,Clark E,Levy S,Detraux D,Leonard A,Beussman K,Showalter MR,Smith AT,Hofsteen P,Yang X,Macadangdang J,Manninen T,Raftery D,Madan A,Suomalainen A,Kim DH,Murry CE,Fiehn O,Sniadecki NJ,Wang Y,Ruohola-Baker H
A-11122 was used in Immunocytochemistry-immunoflourescence to reveal that HADHA is requited for fatty acid beta-oxidation and cardiolipin remodelling, essential for functional mitochondria in human cardiomyocytes.
Fri Oct 11 00:00:00 UTC 2019
Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis.
Scientific reports
Asakawa M,Itoh M,Suganami T,Sakai T,Kanai S,Shirakawa I,Yuan X,Hatayama T,Shimada S,Akiyama Y,Fujiu K,Inagaki Y,Manabe I,Yamaoka S,Yamada T,Tanaka S,Ogawa Y
A-11122 was used in Immunohistochemistry to reveal upregulation of cancer-associated gene expression in activated fibroblasts in NASH, which would contribute to the progression from NASH to HCC.
Fri Dec 20 00:00:00 UTC 2019
The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila.
eLife
Domsch K,Carnesecchi J,Disela V,Friedrich J,Trost N,Ermakova O,Polychronidou M,Lohmann I
A-11122 was used in Western Blotting to study the mechanism by which alternative fate genes are lineage specifically silenced.
Fri May 03 00:00:00 UTC 2019
Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss.
Human gene therapy
Akil O,Blits B,Lustig LR,Leake PA
A-11122 was used in Immunohistochemistry to demonstrate that AAV-5 is a potentially useful gene therapy vector for the cochlea, resulting in extremely high levels of transgene expression in the cochlear inner hair cells and SGN.
Tue Jan 01 00:00:00 UTC 2019
Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.
Scientific reports
Schneider A,Kurz S,Manske K,Janas M,Heikenwälder M,Misgeld T,Aichler M,Weissmann SF,Zischka H,Knolle P,Wohlleber D
A-11122 was used in Immunohistochemistry to report a methodology to analyse mitochondrial properties at the single-organelle level during viral infection using a recombinant adenovirus coding for a mitochondrial tracer protein for tagging and detection by multispectral flow cytometry.
Tue Jun 11 00:00:00 UTC 2019
Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology.
Acta neuropathologica communications
Wenzel HJ,Murray KD,Haify SN,Hunsaker MR,Schwartzer JJ,Kim K,La Spada AR,Sopher BL,Hagerman PJ,Raske C,Severijnen LWFM,Willemsen R,Hukema RK,Berman RF
A-11122 was used in Immunocytochemistry to show that Gfa2-CGG99 expression in mice is sufficient to induce key features of FXTAS pathology, including formation of intranuclear inclusions, translation of FMRpolyG, and deficits in motor function.
Tue Feb 26 00:00:00 UTC 2019
Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.
Scientific reports
Dho SE,Silva-Gagliardi N,Morgese F,Coyaud E,Lamoureux E,Berry DM,Raught B,McGlade CJ
A-11122 was used in Immunocytochemistry-immunoflourescence to examine the role of Parkin in the context of mitochondrial DNA (mtDNA) damage and myocardial aging using a mouse model carrying a proofreading-defective mtDNA polymerase γ (POLG).
Wed Aug 28 00:00:00 UTC 2019
Optimized CRISPR/Cas9-mediated in vivo genome engineering applicable to monitoring dynamics of endogenous proteins in the mouse neural tissues.
Scientific reports
Matsuda T,Oinuma I
A-11122 was used in Immunohistochemistry to disclose a powerful and widely applicable approach for visualization and manipulation of endogenous proteins in neural tissues.
Mon Aug 05 00:00:00 UTC 2019
Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks.
Life science alliance
Ait-Saada A,Khorosjutina O,Chen J,Kramarz K,Maksimov V,Svensson JP,Lambert S,Ekwall K
A-11122 was used in Chromatin immunoprecipitation to identify that chromatin remodeler Fft3 resections nascent strands and restarts blocked DNA replication forks.
Tue Oct 01 00:00:00 UTC 2019
Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum.
Nature microbiology
Bancells C,Llorà-Batlle O,Poran A,Nötzel C,Rovira-Graells N,Elemento O,Kafsack BFC,Cortés A
A-11122 was used in Immunocytochemistry-immunoflourescence to study the initial steps of gametocytogenesis in Plasmodium falciparum.
Tue Jan 01 00:00:00 UTC 2019
Periosteum-derived mesenchymal progenitor cells in engineered implants promote fracture healing in a critical-size defect rat model.
Journal of tissue engineering and regenerative medicine
González-Gil AB,Lamo-Espinosa JM,Muiños-López E,Ripalda-Cemboráin P,Abizanda G,Valdés-Fernández J,López-Martínez T,Flandes-Iparraguirre M,Andreu I,Elizalde MR,Stuckensen K,Groll J,De-Juan-Pardo EM,Prósper F,Granero-Moltó F
A-11122 was used in Immunohistochemistry to compare the therapeutic potential of different sources of mesenchymal stem cells in combination with biomaterials in a bone nonunion model.
Wed May 01 00:00:00 UTC 2019
A circadian output center controlling feeding:fasting rhythms in Drosophila.
PLoS genetics
Dreyer AP,Martin MM,Fulgham CV,Jabr DA,Bai L,Beshel J,Cavanaugh DJ
A-11122 was used in Immunohistochemistry to identify a non-clock cell neuronal population in Drosophila that regulates feeding rhythms and furthermore demonstrate dissociable control of circadian and homeostatic aspects of feeding regulation by molecularly-defined neurons in a putative circadian output hub.
Fri Nov 01 00:00:00 UTC 2019
mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR.
Frontiers in cellular neuroscience
Sanders SS,De Simone FI,Thomas GM
A-11122 was used in Western Blotting to determine the mechanism underlying the regulation of mTORC1 membrane targeting.
Tue Sep 29 00:00:00 UTC 2020
Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs.
eLife
Ni JD,Gurav AS,Liu W,Ogunmowo TH,Hackbart H,Elsheikh A,Verdegaal AA,Montell C
A-11122 was used in Immunohistochemistry to propose that dFB neurons integrate synaptic inputs from distinct sets of upstream sleep-promoting circadian clock neurons, and arousal neurons.
Tue Feb 05 00:00:00 UTC 2019
A Role for Drosophila Amyloid Precursor Protein in Retrograde Trafficking of L1-Type Cell Adhesion Molecule Neuroglian.
Frontiers in cellular neuroscience
Penserga T,Kudumala SR,Poulos R,Godenschwege TA
A-11122 was used in Immunohistochemistry to characterize the role of the Drosophila homolog in the adult giant fiber neurons.
Thu Jul 18 00:00:00 UTC 2024
Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in H3K4me3 independently from histone H2B monoubiquitination.
Genome biology
Fiorucci AS,Bourbousse C,Concia L,Rougée M,Deton-Cabanillas AF,Zabulon G,Layat E,Latrasse D,Kim SK,Chaumont N,Lombard B,Stroebel D,Lemoine S,Mohammad A,Blugeon C,Loew D,Bailly C,Bowler C,Benhamed M,Barneche F
A-11122 was used in Immunoprecipitation to study the evolutionarily conserved COMPASS-like complex in plant systems.
Tue May 21 00:00:00 UTC 2019
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.
Scientific reports
Matsuzaki T,Yoshihara T,Ohtsuka T,Kageyama R
A-11122 was used in Immunohistochemistry-immunofluorescence to indicate that Hes1 is functionally important for normal behaviors not only in excitatory neurons but also in inhibitory neurons in the adult brain.
Mon Jun 03 00:00:00 UTC 2019
Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure.
eLife
Das Gupta PT,Narasimha M
A-11122 was used in Immunohistochemistry to demonstrate that epidermal flanks modulate cell numbers and geometry of their fusing fronts to achieve fusion fidelity.
Wed Apr 17 00:00:00 UTC 2019
Grafted Human iPSC-Derived Neural Progenitor Cells Express Integrins and Extend Long-Distance Axons Within the Developing Corticospinal Tract.
Frontiers in cellular neuroscience
Forbes LH,Andrews MR
A-11122 was used in Western Blotting to study if human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) increase expression of α9 integrin within developing rat corticospinal tract (CST).
Thu Oct 01 00:00:00 UTC 2020
Grafted Human iPSC-Derived Neural Progenitor Cells Express Integrins and Extend Long-Distance Axons Within the Developing Corticospinal Tract.
Frontiers in cellular neuroscience
Forbes LH,Andrews MR
A-11122 was used in Western Blotting to study if human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) increase expression of α9 integrin within developing rat corticospinal tract (CST).
Thu Oct 01 00:00:00 UTC 2020
Grafted Human iPSC-Derived Neural Progenitor Cells Express Integrins and Extend Long-Distance Axons Within the Developing Corticospinal Tract.
Frontiers in cellular neuroscience
Forbes LH,Andrews MR
A-11122 was used in Western Blotting to study if human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) increase expression of α9 integrin within developing rat corticospinal tract (CST).
Thu Oct 01 00:00:00 UTC 2020
scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling.
eLife
Lush ME,Diaz DC,Koenecke N,Baek S,Boldt H,St Peter MK,Gaitan-Escudero T,Romero-Carvajal A,Busch-Nentwich EM,Perera AG,Hall KE,Peak A,Haug JS,Piotrowski T
A-11122 was used in Immunohistochemistry to study signalling patterns which trigger hair cell production in mammals by use of scRNA-Seq analysis.
Fri Jan 25 00:00:00 UTC 2019
Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells.
Current biology : CB
Nano M,Gemble S,Simon A,Pennetier C,Fraisier V,Marthiens V,Basto R
A-11122 was used in Immunohistochemistry to support a model in which DNA damage at mitotic entry can generate DNA structural abnormalities that might contribute to the onset of genetic instability.
Mon Nov 18 00:00:00 UTC 2019
AAV-Mediated Gene Delivery to the Inner Ear.
Methods in molecular biology (Clifton, N.J.)
Akil O,Lustig L
A-11122 was used in Immunohistochemistry to describe a method of virally mediated gene delivery into the cochlear scala tympani through the RWM.
Tue Jul 16 00:00:00 UTC 2019
Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.
Neoplasia (New York, N.Y.)
Chung WC,Zhou Y,Atfi A,Xu K
A-11122 was used in Immunohistochemistry to reveal downregulation of Notch signalling and Mist1 expression during the initiation of Kras-driven gastric tumourigenesis.
Thu Aug 01 00:00:00 UTC 2019
Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.
eLife
Yang F,Quan Z,Huang H,He M,Liu X,Cai T,Xi R
A-11122 was used in Immunohistochemistry to provide a molecular connection between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development, transposon silencing, and heterochromatin formation.
Wed Jan 16 00:00:00 UTC 2019
Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.
eLife
Yang F,Quan Z,Huang H,He M,Liu X,Cai T,Xi R
A-11122 was used in Immunohistochemistry to provide a molecular connection between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development, transposon silencing, and heterochromatin formation.
Wed Jan 16 00:00:00 UTC 2019
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.
eLife
Manzo E,Lorenzini I,Barrameda D,O'Conner AG,Barrows JM,Starr A,Kovalik T,Rabichow BE,Lehmkuhl EM,Shreiner DD,Joardar A,Liévens JC,Bowser R,Sattler R,Zarnescu DC
A-11122 was used in Western Blotting to find significant alterations in glucose metabolism including increased pyruvate, suggesting that modulating glycolysis may be neuroprotective.
Mon Jun 10 00:00:00 UTC 2019
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development.
Neural development
Lucas JA,Schmidt TM
A-11122 was used in Immunohistochemistry to show that ipRGC subtypes are distinguishable from each other early in postnatal development.
Fri Aug 30 00:00:00 UTC 2019
Parental centrioles are dispensable for deuterosome formation and function during basal body amplification.
EMBO reports
Zhao H,Chen Q,Fang C,Huang Q,Zhou J,Yan X,Zhu X
A-11122 was used in Western Blot to show that both parental centrioles are dispensable for deuterosome formation and deuterosomes can be assembled autonomously to mediate de novo centriole amplification in multiciliated cells.
Mon Apr 01 00:00:00 UTC 2019
Stress-induced phospho-ubiquitin formation causes parkin degradation.
Scientific reports
Kovalchuke L,Mosharov EV,Levy OA,Greene LA
A-11122 was used in Immunocytochemistry to determine the mechanisms by which stress decreases parkin protein levels using cultured neuronal cells and the PD-relevant stressor, L-DOPA.
Mon Aug 12 00:00:00 UTC 2019
The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti.
eLife
Matthews BJ,Younger MA,Vosshall LB
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest the role of ppk301 in egg-laying at different salt concentrations for the female Aedes mosquito.
Tue May 21 00:00:00 UTC 2019
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell reports
Chiu AM,Wang J,Fiske MP,Hubalkova P,Barse L,Gray JA,Sanz-Clemente A
A-11122 was used in Western Blot to find that phosphorylation of GluN2B at S1480 maintains NMDARs at extrasynaptic membranes as part of a protein complex containing protein phosphatase 1 (PP1).
Tue Jul 09 00:00:00 UTC 2019
Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation.
Development (Cambridge, England)
Dhiman N,Shweta K,Tendulkar S,Deshpande G,Ratnaparkhi GS,Ratnaparkhi A
A-11122 was used in Immunohistochemistry to identify mon1 as a novel molecular player in the brain-gonad axis and underscores the significance of inter-organ systemic communication during development.
Wed Jul 10 00:00:00 UTC 2019
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.
eLife
Kon E,Calvo-Jiménez E,Cossard A,Na Y,Cooper JA,Jossin Y
A-11122 was used in Western Blotting to reveal novel functions for FGFRs in cortical projection neuron migration, suggest a physiological role for FGFR and N-Cadherin interaction in vivo and identify Reelin as an extracellular upstream regulator and Erk1/2 as downstream effectors of FGFRs during neuron migration.
Wed Oct 02 00:00:00 UTC 2019
CENP-A Ubiquitylation Is Indispensable to Cell Viability.
Developmental cell
Niikura Y,Kitagawa R,Fang L,Kitagawa K
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to show that the Flag-tagged or untagged CENP-A K124R mutant is lethal.
Mon Sep 23 00:00:00 UTC 2019
The Drosophila Hedgehog receptor component Interference hedgehog (Ihog) mediates cell-cell interactions through trans-homophilic binding.
The Journal of biological chemistry
Wu X,Zhang Y,Chuang KH,Cai X,Ajaz H,Zheng X
A-11122 was used in Immunocytochemistry to reveal a mechanism for Ihog-mediated cell-cell interactions but also suggest a direct Hh-mediated regulation of both intracellular signaling and cell adhesion through Ihog.
Fri Aug 16 00:00:00 UTC 2019
Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.
Nature communications
Ahmad ST,Rogers AD,Chen MJ,Dixit R,Adnani L,Frankiw LS,Lawn SO,Blough MD,Alshehri M,Wu W,Marra MA,Robbins SM,Cairncross JG,Schuurmans C,Chan JA
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that forebrain-specific Cic deletion increases proliferation and self-renewal of neural stem cells.
Wed May 01 00:00:00 UTC 2019
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Terreros-Roncal J,Flor-García M,Moreno-Jiménez EP,Pallas-Bazarra N,Rábano A,Sah N,van Praag H,Giacomini D,Schinder AF,Ávila J,Llorens-Martín M
A-11122 was used in Immunohistochemistry to study the therapeutic potential of applying chemoactivation to adult-born dentate granule cells in a mouse model of a neurodegenerative disease.
Wed Jul 17 00:00:00 UTC 2019
Identification of a bilirubin receptor that may mediate a component of cholestatic itch.
eLife
Meixiong J,Vasavda C,Green D,Zheng Q,Qi L,Kwatra SG,Hamilton JP,Snyder SH,Dong X
A-11122 was used in Immunohistochemistry to show that genetic deletion of either Mrgpra1 or Blvra, the gene that encodes the bilirubin-producing enzyme biliverdin reductase, attenuates itch.
Mon Jan 21 00:00:00 UTC 2019
Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort.
Cells
Toyoda Y,Mančíková A,Krylov V,Morimoto K,Pavelcová K,Bohatá J,Pavelka K,Pavlíková M,Suzuki H,Matsuo H,Takada T,Stiburkova B
A-11122 was used in Western Blotting to contribute to deepening the understanding of ABCG2-related gout/hyperuricemia risk and the biochemical characteristics of the ABCG2 protein.
Thu Apr 18 00:00:00 UTC 2019
Differential interactions of missing in metastasis and insulin receptor tyrosine kinase substrate with RAB proteins in the endocytosis of CXCR4.
The Journal of biological chemistry
Li L,Baxter SS,Zhao P,Gu N,Zhan X
A-11122 was used in Immunocytochemistry-immunoflourescence to provide first evidence that the SH3 domain is critical in the regulation of specific endocytic pathways by I-BAR domain proteins.
Fri Apr 19 00:00:00 UTC 2019
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
eLife
Jia R,Bonifacino JS
A-11122 was used in Western Blot to demonstrate that UBA6 and BIRC6 negatively regulate autophagy by limiting the availability of LC3B.
Wed Nov 06 00:00:00 UTC 2019
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.
Life science alliance
Rosales MAB,Shu DY,Iacovelli J,Saint-Geniez M
A-11122 was used in Immunohistochemistry to establish that PGC-1α is required to maintain the functional and phenotypical status of retinal pigment epithelium by supporting the cells'' oxidative metabolism and autography-mediated repression of epithelial to mesenchymal transition.
Sat Jun 01 00:00:00 UTC 2019
Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits.
eNeuro
Yan Y,Beckley NA,Kim VJ,Drenan RM
A-11122 was used in Immunohistochemistry to uncover a complex system of local circuitry in the VTA that is modulated by nAChR activity.
Wed Jun 03 00:00:00 UTC 2020
The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo.
Nature communications
Vijayakumar J,Perrois C,Heim M,Bousset L,Alberti S,Besse F
A-11122 was used in Immunohistochemistry-immunofluorescence to show that prion-like domains of Dropshila Imp is essential for developmentally-controlled localisation of Imp RNP granules to axons and regulates in vivo axonal remodeling.
Thu Jun 13 00:00:00 UTC 2019
Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.
Nature communications
Tenedini FM,Sáez González M,Hu C,Pedersen LH,Petruzzi MM,Spitzweck B,Wang D,Richter M,Petersen M,Szpotowicz E,Schweizer M,Sigrist SJ,Calderon de Anda F,Soba P
A-11122 was used in Immunohistochemistry to investigate, using a Drosophila model, the role of Tao kinase in regulating neuron development and circuit specificity and function.
Mon Aug 05 00:00:00 UTC 2019
A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus.
Scientific reports
Li J,Perfetto M,Materna C,Li R,Thi Tran H,Vleminckx K,Duncan MK,Wei S
A-11122 was used in Immunohistochemistry to determine the role of snai2 in cranial neural crest differentiation in Xenopus.
Thu Aug 01 00:00:00 UTC 2019
Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS.
Nature communications
Chung Y,Zhu Y,Wu MF,Simonini S,Kuhn A,Armenta-Medina A,Jin R,Østergaard L,Gillmor CS,Wagner D
A-11122 was used in Chromatin immunoprecipitation to show that downregulation of the STM pluripotency gene promotes initiation of flowers and uncover mechanisms of STM silencing.
Thu Feb 21 00:00:00 UTC 2019
AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells.
Scientific reports
Tudurí E,Glavas MM,Asadi A,Baker RK,Ellis CE,Soukhatcheva G,Philit M,Huynh FK,Johnson JD,Bruce Verchere C,Kieffer TJ
A-11122 was used in Immunohistochemistry-immunofluorescence to create a new double stranded adeno-associated virus AAV GCG-EGFP as a tool to identify primary glucagon-secreting α-cells.
Thu Jul 25 00:00:00 UTC 2019
A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission.
Neuron
Liu Q,Sinnen BL,Boxer EE,Schneider MW,Grybko MJ,Buchta WC,Gibson ES,Wysoczynski CL,Ford CP,Gottschalk A,Aoto J,Tucker CL,Kennedy MJ
A-11122 was used in Western Blotting to demonstrate the utility of this approach for inducibly disrupting excitatory neurotransmission, providing a first-in-class optogenetic tool for persistent, light-triggered synaptic inhibition.
Wed Mar 06 00:00:00 UTC 2019
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection.
Neuron
Adaikkan C,Middleton SJ,Marco A,Pao PC,Mathys H,Kim DN,Gao F,Young JZ,Suk HJ,Boyden ES,McHugh TJ,Tsai LH
A-11122 was used in Immunohistochemistry to study the role of gamma entertainment using sensory stimuli can affect neurodegeneration or cognitive performance.
Wed Jun 05 00:00:00 UTC 2019
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Nature communications
Zhang J,Fujiwara Y,Yamamoto S,Shibuya H
A-11122 was used in Immunocytochemistry-immunoflourescence to study the role of BRCA2 in the repair mechanism of double stranded breaks.
Wed Feb 13 00:00:00 UTC 2019
Leaky expression of channelrhodopsin-2 (ChR2) in Ai32 mouse lines.
PloS one
Prabhakar A,Vujovic D,Cui L,Olson W,Luo W
A-11122 was used in Immunoprecipitation to study leaky 'off-target' (Cre-independent) ChR2-EYFP expression in Ai32/Ai32 homozygous mice.
Fri Dec 13 00:00:00 UTC 2019
Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo.
Cells
Jimenez-Rojo L,Pagella P,Harada H,Mitsiadis TA
A-11122 was used in Immunohistochemistry to study how alterations in the microenvironment of dental epithelial stem cells can lead to the regeneration of non-dental tissues.
Tue Oct 22 00:00:00 UTC 2019
Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket.
The Journal of biological chemistry
Chik JK,Moiseeva V,Goel PK,Meinen BA,Koldewey P,An S,Mellone BG,Subramanian L,Cho US
A-11122 was used in Immunocytochemistry-immunoflourescence to unveil the evolutionarily conserved and unique features of the CENP-C cupin domain and uncover the mechanism by which it functions as a recruitment factor.
Fri Sep 20 00:00:00 UTC 2019
Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.
Developmental biology
Harder M,Reeves W,Byers C,Santiago M,Veeman M
A-11122 was used in Immunohistochemistry to show that the posterior-enriched notochord expression of C11.331 depends on multiple inputs, including Wnt and FGF signals from the tip of the tail, multiple notochord-specific regulators, and yet-to-be identified regulators of regional identity within the notochord.
Mon Apr 15 00:00:00 UTC 2019
Robo2 regulates synaptic oxytocin content by affecting actin dynamics.
eLife
Anbalagan S,Blechman J,Gliksberg M,Gordon L,Rotkopf R,Dadosh T,Shimoni E,Levkowitz G
A-11122 was used in Immunohistochemistry-immunofluorescence to link Slit3-Robo2-Cdc42 which controls local actin dynamics with the maintenance of synaptic neuropeptide levels.
Mon Jun 10 00:00:00 UTC 2019
The Spatial Extent of Optogenetic Silencing in Transgenic Mice Expressing Channelrhodopsin in Inhibitory Interneurons.
Cell reports
Babl SS,Rummell BP,Sigurdsson T
A-11122 was used in Immunohistochemistry to reveal important constraints on using inhibitory interneuron activation to silence neuronal activity and emphasize the necessity of carefully controlling light stimulation parameters when using this silencing strategy.
Tue Oct 29 00:00:00 UTC 2019
Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.
eLife
Nam H,Jeon S,An H,Yoo J,Lee HJ,Lee SK,Lee S
A-11122 was used in Immunohistochemistry to reveal that Shh, secreted from MNs, plays a crucial role in generating MN diversity via a regulatory axis of Shh-AKT-ARHGAP36 in the developing mouse spinal cord.
Mon Jul 15 00:00:00 UTC 2019
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
eLife
Uezu A,Hisey E,Kobayashi Y,Gao Y,Bradshaw TW,Devlin P,Rodriguiz R,Tata PR,Soderling S
A-11122 was used in Western Blotting to report Inhibitory Synaptic protein 1 (InSyn1) is a critical component of the DGC whose loss alters the composition of the GABAergic synapses, excitatory/inhibitory balance in vitro and in vivo, and cognitive behavior.
Thu Dec 12 00:00:00 UTC 2019
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
PLoS biology
Mirvis M,Siemers KA,Nelson WJ,Stearns TP
A-11122 was used in Immunocytochemistry to investigate and characterise events in cilium loss in mammalian cells.
Mon Jul 01 00:00:00 UTC 2019
RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.
PLoS genetics
Pavlova GA,Popova JV,Andreyeva EN,Yarinich LA,Lebedev MO,Razuvaeva AV,Dubatolova TD,Oshchepkova AL,Pellacani C,Somma MP,Pindyurin AV,Gatti M
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest that the mitotic phenotypes caused by Rcd1, Rcd5, MBD-R2 or Wds depletion are primarily due to reduced transcription of genes involved in kinetochore assembly and centriole duplication.
Sun Sep 01 00:00:00 UTC 2019
Methamphetamine regulation of activity and topology of ventral midbrain networks.
PloS one
Miller DR,Lebowitz JJ,Guenther DT,Refowich AJ,Hansen C,Maurer AP,Khoshbouei H
A-11122 was used in Immunocytochemistry to establish primary ventral midbrain networks culture as a viable model system that reveals specific changes in network activity, connectivity, and topology modulation by methamphetamine.
Mon Mar 23 00:00:00 UTC 2020
Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels.
Nature communications
Salehin M,Li B,Tang M,Katz E,Song L,Ecker JR,Kliebenstein DJ,Estelle M
A-11122 was used in Chromatin immunoprecipitation to describe a mechanism by which auxin-sensitive Aux/IAA genes promote drought tolerance in Arabidopsis through the regulation of glucosinolate levels.
Fri Sep 06 00:00:00 UTC 2019
Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice.
Frontiers in neuroscience
Kaur T,Clayman AC,Nash AJ,Schrader AD,Warchol ME,Ohlemiller KK
A-11122 was used in Immunohistochemistry to study the role of macrophage fractalkine signalling on the repair of damaged synapses.
Wed Sep 30 00:00:00 UTC 2020
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
eLife
Torres SE,Gallagher CM,Plate L,Gupta M,Liem CR,Guo X,Tian R,Stroud RM,Kampmann M,Weissman JS,Walter P
A-11122 was used in Western Blotting to reveal that Ceapins function by chemical-induced misdirection.
Fri May 31 00:00:00 UTC 2019
Developmental organization of central neurons in the adult Drosophila ventral nervous system.
The Journal of comparative neurology
Shepherd D,Sahota V,Court R,Williams DW,Truman JW
A-11122 was used in Immunohistochemistry to provide a baseline of understanding of the functional organization of the adult Drosophila VNS.
Tue Oct 15 00:00:00 UTC 2019
Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern.
eLife
Lawton AK,Engstrom T,Rohrbach D,Omura M,Turnbull DH,Mamou J,Zhang T,Schwarz JM,Joyner AL
A-11122 was used in Immunohistochemistry to combine existing models with in vivo data collected from mouse cerebellum, to show how cerebellar folding emerges.
Tue Apr 16 00:00:00 UTC 2019
Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.
Molecular therapy : the journal of the American Society of Gene Therapy
Kuhlmann AS,Haworth KG,Barber-Axthelm IM,Ironside C,Giese MA,Peterson CW,Kiem HP
A-11122 was used in Immunohistochemistry to indicate that the bNAb secretion from HSPC-derived cells in mice is functional and can affect viral infection and CD4+ cell maintenance.
Wed Jan 02 00:00:00 UTC 2019
Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.
Nature communications
Wu S,Guo C,Zhao H,Sun M,Chen J,Han C,Peng Q,Qiao H,Peng P,Liu Y,Luo SD,Pan Y
A-11122 was used in Immunohistochemistry to identify the Cholecystokinin-like peptide Drosulfakinin that functions at single-neuron resolution to suppress male sexual behaviour in Drosophila.
Fri Oct 18 00:00:00 UTC 2019
Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila.
eLife
Lattner J,Leng W,Knust E,Brankatschk M,Flores-Benitez D
A-11122 was used in Western Blot to identify Crumbs as an essential hub required to maintain the organization of the apical membrane and the physiological activity of the larval salivary gland.
Thu Nov 07 00:00:00 UTC 2019
Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels.
Frontiers in immunology
Bálint L,Ocskay Z,Deák BA,Aradi P,Jakus Z
A-11122 was used in Immunohistochemistry to demonstrate that lymphatics present in the dura mater are involved in the uptake and transport of macromolecules from the CNS.
Tue Nov 17 00:00:00 UTC 2020
A projection specific logic to sampling visual inputs in mouse superior colliculus.
eLife
Reinhard K,Li C,Do Q,Burke EG,Heynderickx S,Farrow K
A-11122 was used in Immunohistochemistry to open the possibility that projection-specific sampling of retinal inputs forms a basis for the selective triggering of behaviors by the superior colliculus.
Thu Nov 21 00:00:00 UTC 2019
Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.
Scientific reports
Gannon AL,O'Hara L,Mason JI,Rebourcet D,Smith S,Traveres A,Alcaide-Corral CJ,Frederiksen H,Jørgensen A,Milne L,Mitchell RT,Smith LB
A-11122 was used in Immunohistochemistry to investigate, using a novel mouse model, the effects of ablation of Glucocorticoid Receptor (GR) in the hindbrain, on stress-related behaviour and physiology.
Fri Mar 01 00:00:00 UTC 2019
Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling.
eLife
Zacharioudaki E,Falo Sanjuan J,Bray S
A-11122 was used in Immunoprecipitation to show that depletion of the Mi-2/NuRD ATP remodelling complex dramatically enhances Notch-induced hyperplasia in neural stem cells of Drosophila.
Tue Jan 29 00:00:00 UTC 2019
Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling.
eLife
Zacharioudaki E,Falo Sanjuan J,Bray S
A-11122 was used in Immunoprecipitation to show that depletion of the Mi-2/NuRD ATP remodelling complex dramatically enhances Notch-induced hyperplasia in neural stem cells of Drosophila.
Tue Jan 29 00:00:00 UTC 2019
Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
The Biochemical journal
Wang J,Ren XR,Piao H,Zhao S,Osada T,Premont RT,Mook RA,Morse MA,Lyerly HK,Chen W
A-11122 was used in Immunocytochemistry to provide a mechanistic understanding of the role of autophagosomes in the inhibition of Wnt signaling by niclosamide and may provide biomarkers to assist selection of patients whose tumors are likely to respond to niclosamide.
Fri Feb 08 00:00:00 UTC 2019
Sniffer cells for the detection of neural Angiotensin II in vitro.
Scientific reports
Farmer GE,Amune A,Bachelor ME,Duong P,Yuan JP,Cunningham JT
A-11122 was used in Western Blotting to show that stable sniffer cell lines may be a viable method for detecting neuropeptide release in vitro, while still being able to distinguish differences in neuropeptide concentration.
Wed Jun 19 00:00:00 UTC 2019
Exploring First Interactions Between Ostreid Herpesvirus 1 (OsHV-1) and Its Host, Crassostrea gigas: Effects of Specific Antiviral Antibodies and Dextran Sulfate.
Frontiers in microbiology
Martenot C,Faury N,Morga B,Degremont L,Lamy JB,Houssin M,Renault T
A-11122 was used in In vitro Assay to contribute to better understanding the pathogenesis of the viral infection, especially during the first stage of OsHV-1 infection, and open the way toward new approaches to control OsHV-1 infection in confined facilities.
Thu Oct 01 00:00:00 UTC 2020
Transfer of Functional Cargo in Exomeres.
Cell reports
Zhang Q,Higginbotham JN,Jeppesen DK,Yang YP,Li W,McKinley ET,Graves-Deal R,Ping J,Britain CM,Dorsett KA,Hartman CL,Ford DA,Allen RM,Vickers KC,Liu Q,Franklin JL,Bellis SL,Coffey RJ
A-11122 was used in Immunocytochemistry to identify distinct functions of exomeres mediated by two of their cargo, the Β-galactoside α2,6-sialyltransferase 1 (ST6Gal-I) that α2,6- sialylates N-glycans, and the EGFR ligand, amphiregulin (AREG).
Tue Apr 16 00:00:00 UTC 2019
FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Schrauwen I,Giese AP,Aziz A,Lafont DT,Chakchouk I,Santos-Cortez RLP,Lee K,Acharya A,Khan FS,Ullah A,Nickerson DA,Bamshad MJ,Ali G,Riazuddin S,Ansar M,Ahmad W,Ahmed ZM,Leal SM
A-11122 was used in Immunoprecipitation to present a new nonsyndromic PAPA ciliopathy due to a loss-of-function variant in FAM92A. © 2018 American Society for Bone and Mineral Research.
Fri Feb 01 00:00:00 UTC 2019
FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Schrauwen I,Giese AP,Aziz A,Lafont DT,Chakchouk I,Santos-Cortez RLP,Lee K,Acharya A,Khan FS,Ullah A,Nickerson DA,Bamshad MJ,Ali G,Riazuddin S,Ansar M,Ahmad W,Ahmed ZM,Leal SM
A-11122 was used in Immunoprecipitation to present a new nonsyndromic PAPA ciliopathy due to a loss-of-function variant in FAM92A. © 2018 American Society for Bone and Mineral Research.
Fri Feb 01 00:00:00 UTC 2019
Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.
Scientific reports
Zaborowski MP,Cheah PS,Zhang X,Bushko I,Lee K,Sammarco A,Zappulli V,Maas SLN,Allen RM,Rumde P,György B,Aufiero M,Schweiger MW,Lai CP,Weissleder R,Lee H,Vickers KC,Tannous BA,Breakefield XO
A-11122 was used in Western Blotting to develop the membrane embedded Gaussia luciferase as a marker for membrane protein loss and show ectodomain shedding from extracellular vesicles is continuous and mediated by proteases.
Fri Nov 22 00:00:00 UTC 2019
Rapid single-wavelength lightsheet localization microscopy for clarified tissue.
Nature communications
Chu LA,Lu CH,Yang SM,Liu YT,Feng KL,Tsai YC,Chang WK,Wang WC,Chang SW,Chen P,Lee TK,Hwu YK,Chiang AS,Chen BC
A-11122 was used in Immunohistochemistry to develop a single-wavelength Bessel lightsheet method, optimized for refractive-index matching with clarified specimens to overcome the aberrations encountered in imaging thick tissues.
Fri Oct 18 00:00:00 UTC 2019
Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
International journal of molecular sciences
Steinmetz EL,Dewald DN,Luxem N,Walldorf U
A-11122 was used in Immunohistochemistry-immunofluorescence to uncover a physical interaction between HipK and the three homeodomain proteins in vivo using bimolecular fluorescence complementation.
Fri Apr 19 00:00:00 UTC 2019
M1 Intrinsically Photosensitive Retinal Ganglion Cells Integrate Rod and Melanopsin Inputs to Signal in Low Light.
Cell reports
Lee SK,Sonoda T,Schmidt TM
A-11122 was used in Immunohistochemistry to show variability in the rod input to M1 ipRGCs and a surprising contribution of melanopsin to the light responses of M1 ipRGCs at very low light.
Tue Dec 10 00:00:00 UTC 2019
Classes of non-conventional tetraspanins defined by alternative splicing.
Scientific reports
Hochheimer N,Sies R,Aschenbrenner AC,Schneider D,Lang T
A-11122 was used in Western Blotting to analyse alternative splicing of tetraspanins.
Tue Oct 01 00:00:00 UTC 2019
Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.
Nature medicine
Guo N,Soden ME,Herber C,Kim MT,Besnard A,Lin P,Ma X,Cepko CL,Zweifel LS,Sahay A
A-11122 was used in Immunohistochemistry to exemplify a connectivity-based strategy that targets a molecular brake of feedforward inhibition in DG-CA3 and may be harnessed to decrease time-dependent memory generalization in individuals with PTSD and improve memory precision in aging individuals.
Tue May 01 00:00:00 UTC 2018
In utero CRISPR-mediated therapeutic editing of metabolic genes.
Nature medicine
Rossidis AC,Stratigis JD,Chadwick AC,Hartman HA,Ahn NJ,Li H,Singh K,Coons BE,Li L,Lv W,Zoltick PW,Alapati D,Zacharias W,Jain R,Morrisey EE,Musunuru K,Peranteau WH
A-11122 was used in Immunohistochemistry to demonstrate the possibility of efficiently performing gene editing before birth, giving potential to new therapeutic approach for selected congenital genetic disorders.
Mon Oct 01 00:00:00 UTC 2018
A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.
Nature
Parua PK,Booth GT,Sansó M,Benjamin B,Tanny JC,Lis JT,Fisher RP
A-11122 was used in Western Blotting to suggest that the transition of Pol II from elongation to termination coincides with a Dis2-dependent reversal of Cdk9 signalling-a switch that is analogous to a Cdk1-PP1 circuit that controls mitotic progression 4.
Fri Jun 01 00:00:00 UTC 2018
A synaptic threshold mechanism for computing escape decisions.
Nature
Evans DA,Stempel AV,Vale R,Ruehle S,Lefler Y,Branco T
A-11122 was used in Immunohistochemistry to show that dPAG glutamatergic neurons compute escape decisions and escape vigour using a synaptic mechanism to threshold threat information received from the mSC.
Fri Jun 01 00:00:00 UTC 2018
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
Nature
Parker JG,Marshall JD,Ahanonu B,Wu YW,Kim TH,Grewe BF,Zhang Y,Li JZ,Ding JB,Ehlers MD,Schnitzer MJ
A-11122 was used in Immunohistochemistry to show that both the spatiotemporal profiles and rates of SPN activity appear crucial to striatal function, and next-generation treatments for basal ganglia disorders should target both facets of striatal activity.
Tue May 01 00:00:00 UTC 2018
Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.
Cell
Hultman R,Ulrich K,Sachs BD,Blount C,Carlson DE,Ndubuizu N,Bagot RC,Parise EM,Vu MT,Gallagher NM,Wang J,Silva AJ,Deisseroth K,Mague SD,Caron MG,Nestler EJ,Carin L,Dzirasa K
A-11122 was used in Immunohistochemistry to discover a spatiotemporal dynamic network that predicts the emergence of major depressive disorder (MDD)-related behavioral dysfunction in mice subjected to chronic social defeat stress.
Thu Mar 22 00:00:00 UTC 2018
A Neural Circuit for the Suppression of Pain by a Competing Need State.
Cell
Alhadeff AL,Su Z,Hernandez E,Klima ML,Phillips SZ,Holland RA,Guo C,Hantman AW,De Jonghe BC,Betley JN
A-11122 was used in Immunohistochemistry-immunofluorescence to determine the neural processes that mediate competing survival needs between hunger and pain.
Thu Mar 22 00:00:00 UTC 2018
Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation.
Nature neuroscience
Wuttke TV,Markopoulos F,Padmanabhan H,Wheeler AP,Murthy VN,Macklis JD
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that postnatal neocortical connectivity can be reconstituted with point-to-point precision, including cellular integration of specific, molecularly identified projection neuron subtypes into correct position, combined with development of appropriate long-distance projections and synapses.
Sun Apr 01 00:00:00 UTC 2018
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
Cell stem cell
Friedman CE,Nguyen Q,Lukowski SW,Helfer A,Chiu HS,Miklas J,Levy S,Suo S,Han JJ,Osteil P,Peng G,Jing N,Baillie GJ,Senabouth A,Christ AN,Bruxner TJ,Murry CE,Wong ES,Ding J,Wang Y,Hudson J,Ruohola-Baker H,Bar-Joseph Z,Tam PPL,Powell JE,Palpant NJ
A-11122 was used in Western Blot to provide a key transcriptional roadmap of in vitro cardiac differentiation at single-cell resolution, revealing fundamental mechanisms underlying heart development and differentiation of hPSC-derived cardiomyocytes.
Thu Oct 04 00:00:00 UTC 2018
LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2.
Molecular plant
Wang H,Jiang D,Axelsson E,Lorković ZJ,Montgomery S,Holec S,Pieters BJGE,Al Temimi AHK,Mecinović J,Berger F
A-11122 was used in Western Blotting to suggest that distinct evolutionary pathways led to the interaction between ATRX and HP1 in mammals and its counterpart LHP1 in plants, resulting in distinct modes of transcriptional regulation.
Mon Aug 06 00:00:00 UTC 2018
A WW Domain-Containing Protein Forms Immune Nuclear Bodies against Begomoviruses.
Molecular plant
Calil IP,Quadros IPS,Araújo TC,Duarte CEM,Gouveia-Mageste BC,Silva JCF,Brustolini OJB,Teixeira RM,Oliveira CN,Milagres RWMM,Martins GS,Chory J,Reis PAB,Machado JPB,Fontes EPB
A-11122 was used in Chromatin immunoprecipitation to report the nuclear redistribution of NSP-interacting guanosine triphosphatase by AtWWP1, a WW domain-containing protein that forms immune nuclear bodies against begomoviruses.
Mon Dec 03 00:00:00 UTC 2018
Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons.
The Journal of clinical investigation
Steinkellner T,Zell V,Farino ZJ,Sonders MS,Villeneuve M,Freyberg RJ,Przedborski S,Lu W,Freyberg Z,Hnasko TS
A-11122 was used in Immunohistochemistry to suggest that the balance of VGLUT2 expression is a crucial determinant of DA neuron survival.
Thu Feb 01 00:00:00 UTC 2018
Timing Mechanisms Underlying Gate Control by Feedforward Inhibition.
Neuron
Zhang Y,Liu S,Zhang YQ,Goulding M,Wang YQ,Ma Q
A-11122 was used in Immunohistochemistry-immunofluorescence to study how monosynaptic expression is gated by disynaptic inhibitory inputs.
Wed Sep 05 00:00:00 UTC 2018
FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.
Neuron
Cargnin F,Kwon JS,Katzman S,Chen B,Lee JW,Lee SK
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to investigate molecular regulation of FOXG1 syndrome.
Wed Dec 05 00:00:00 UTC 2018
How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse.
Neuron
Drinnenberg A,Franke F,Morikawa RK,Jüttner J,Hillier D,Hantz P,Hierlemann A,Azeredo da Silveira R,Roska B
A-11122 was used in Immunohistochemistry to reveal how a single interneuron type can differentially shape the dynamical properties of distinct output channels of a brain region.
Wed Jul 11 00:00:00 UTC 2018
A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors.
Neuron
Fang YY,Yamaguchi T,Song SC,Tritsch NX,Lin D
A-11122 was used in Immunohistochemistry-immunofluorescence to identify MPOAEsr1+ cells as an essential population for mediating maternal behaviors, especially pup approach and retrieval.
Wed Apr 04 00:00:00 UTC 2018
Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila.
The EMBO journal
Rust K,Tiwari MD,Mishra VK,Grawe F,Wodarz A
A-11122 was used in Immunohistochemistry to reveal an evolutionarily conserved functional link between Myc, the Tip60 complex, and the molecular network controlling cell polarity and asymmetric cell division.
Wed Aug 15 00:00:00 UTC 2018
Synaptic activity-induced glycolysis facilitates membrane lipid provision and neurite outgrowth.
The EMBO journal
Segarra-Mondejar M,Casellas-Díaz S,Ramiro-Pareta M,Müller-Sánchez C,Martorell-Riera A,Hermelo I,Reina M,Aragonés J,Martínez-Estrada OM,Soriano FX
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest that the manipulation of neuronal glucose metabolism could be used to treat some brain developmental disorders.
Wed May 02 00:00:00 UTC 2018
Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gordon RE,Zhang L,Peri S,Kuo YM,Du F,Egleston BL,Ng JMY,Andrews AJ,Astsaturov I,Curran T,Yang ZJ
A-11122 was used in Immunohistochemistry to identify the important role for cholesterol in hedgehog pathway medulloblastoma (Hh-MB) tumorigenesis, and investigate the mechanisms by which statins aid the treatment of Hh-MB.
Thu Mar 15 00:00:00 UTC 2018
Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects.
Molecular psychiatry
Chen CC,Lu J,Yang R,Ding JB,Zuo Y
A-11122 was used in Immunohistochemistry to suggest that the PV+ inhibitory circuit is crucial for normal synaptic dynamics in the mouse barrel cortex and sensory function.
Sun Jul 01 00:00:00 UTC 2018
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Developmental cell
Zhao C,Dong C,Frah M,Deng Y,Marie C,Zhang F,Xu L,Ma Z,Dong X,Lin Y,Koenig S,Nait-Oumesmar B,Martin DM,Wu LN,Xin M,Zhou W,Parras C,Lu QR
A-11122 was used in Western Blotting to demonstrate the dual function of CHD8 through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity.
Mon Jun 18 00:00:00 UTC 2018
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Developmental cell
Zhao C,Dong C,Frah M,Deng Y,Marie C,Zhang F,Xu L,Ma Z,Dong X,Lin Y,Koenig S,Nait-Oumesmar B,Martin DM,Wu LN,Xin M,Zhou W,Parras C,Lu QR
A-11122 was used in Western Blotting to demonstrate the dual function of CHD8 through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity.
Mon Jun 18 00:00:00 UTC 2018
The WAVE Regulatory Complex and Branched F-Actin Counterbalance Contractile Force to Control Cell Shape and Packing in the Drosophila Eye.
Developmental cell
Del Signore SJ,Cilla R,Hatini V
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the remodelling of Drosophila eye lattice cells which preserve cell contacts as they narrow to form the edges of a multicellular hexagonal lattice.
Mon Feb 26 00:00:00 UTC 2018
Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
Cancer research
Nguyen HD,Leong WY,Li W,Reddy PNG,Sullivan JD,Walter MJ,Zou L,Graubert TA
A-11122 was used in Flow cytometry/Cell sorting to study the altered RNA splicing caused by U2AF1 mutant accumulation and the consequential molecular effects.
Sat Sep 15 00:00:00 UTC 2018
In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.
Molecular therapy : the journal of the American Society of Gene Therapy
Ojala DS,Sun S,Santiago-Ortiz JL,Shapiro MG,Romero PA,Schaffer DV
A-11122 was used in Immunohistochemistry to establish the SCHEMA library as a valuable tool for directed evolution and SCH9 as an effective gene delivery vector to investigate subventricular NSCs.
Wed Jan 03 00:00:00 UTC 2018
Response to Persistent ER Stress in Plants: A Multiphasic Process That Transitions Cells from Prosurvival Activities to Cell Death.
The Plant cell
Srivastava R,Li Z,Russo G,Tang J,Bi R,Muppirala U,Chudalayandi S,Severin A,He M,Vaitkevicius SI,Lawrence-Dill CJ,Liu P,Stapleton AE,Bassham DC,Brandizzi F,Howell SH
A-11122 was used in Chromatin immunoprecipitation to induce the unfolded protein response in maize seedlings to characterise the molecular events that occur over time during persistent ER stress.
Fri Jun 01 00:00:00 UTC 2018
Targeted Recruitment of the Basal Transcriptional Machinery by LNK Clock Components Controls the Circadian Rhythms of Nascent RNAs in Arabidopsis.
The Plant cell
Ma Y,Gil S,Grasser KD,Mas P
A-11122 was used in Western Blotting to explain how genome readout of environmental information ultimately results in rhythmic changes of gene expression.
Sun Apr 01 00:00:00 UTC 2018
GRF-interacting factor1 Regulates Shoot Architecture and Meristem Determinacy in Maize.
The Plant cell
Zhang D,Sun W,Singh R,Zheng Y,Cao Z,Li M,Lunde C,Hake S,Zhang Z
A-11122 was used in Chromatin immunoprecipitation to provide insights into the biological functions of gif1.
Thu Feb 01 00:00:00 UTC 2018
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export.
Cell systems
Ege N,Dowbaj AM,Jiang M,Howell M,Hooper S,Foster C,Jenkins RP,Sahai E
A-11122 was used in Immunocytochemistry to investigate the dynamics of YAP1 shuttling in normal and activated fibroblasts, using EYFP-YAP1, quantitative photobleaching methods, and mathematical modeling. Imaging of migrating fibroblasts reveals the tight temporal coupling of cell shape change and altered YAP1 localization.
Wed Jun 27 00:00:00 UTC 2018
Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts.
American journal of human genetics
Ansar M,Chung HL,Taylor RL,Nazir A,Imtiaz S,Sarwar MT,Manousopoulou A,Makrythanasis P,Saeed S,Falconnet E,Guipponi M,Pournaras CJ,Ansari MA,Ranza E,Santoni FA,Ahmed J,Shah I,Gul K,Black GC,Bellen HJ,Antonarakis SE
A-11122 was used in Immunohistochemistry-immunofluorescence to conclude that DNMBP loss-of-function variants cause infantile-onset cataracts in humans.
Thu Oct 04 00:00:00 UTC 2018
βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.
American journal of human genetics
Wang CC,Ortiz-González XR,Yum SW,Gill SM,White A,Kelter E,Seaver LH,Lee S,Wiley G,Gaffney PM,Wierenga KJ,Rasband MN
A-11122 was used in Immunoprecipitation to define a class of spectrinopathies and reveal the molecular pathologies causing nervous-system dysfunction.
Thu Jun 07 00:00:00 UTC 2018
FUT2 Variants Confer Susceptibility to Familial Otitis Media.
American journal of human genetics
Santos-Cortez RLP,Chiong CM,Frank DN,Ryan AF,Giese APJ,Bootpetch Roberts T,Daly KA,Steritz MJ,Szeremeta W,Pedro M,Pine H,Yarza TKL,Scholes MA,Llanes EGDV,Yousaf S,Friedman N,Tantoco MLC,Wine TM,Labra PJ,Benoit J,Ruiz AG,de la Cruz RAR,Greenlee C,Yousaf A,Cardwell J,Nonato RMA,Ray D,Ong KMC,So E,Robertson CE,Dinwiddie J,Lagrana-Villagracia SM,Gubbels SP,Shaikh RS,Cass SP,Einarsdottir E,Lee NR,Schwartz DA,Gloria-Cruz TLI,Bamshad MJ,Yang IV,Kere J,Abes GT,Prager JD,Riazuddin S,Chan AL,Yoon PJ,Nickerson DA,Cutiongco-de la Paz EM,Streubel SO,Reyes-Quintos MRT,Jenkins HA,Mattila P,Chan KH,Mohlke KL,Leal SM,Hafrén L,Chonmaitree T,Sale MM,Ahmed ZM
A-11122 was used in Western Blotting to determine the role of FUT2 in otitis media susceptibility.
Thu Nov 01 00:00:00 UTC 2018
The Bilateral Prefronto-striatal Pathway Is Necessary for Learning New Goal-Directed Actions.
Current biology : CB
Hart G,Bradfield LA,Fok SY,Chieng B,Balleine BW
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that the acquisition of new goal-directed actions depends on the bilateral PL-pDMS pathway driven by intratelencephalic cortical neurons.
Mon Jul 23 00:00:00 UTC 2018
A GABAergic Feedback Shapes Dopaminergic Input on the Drosophila Mushroom Body to Promote Appetitive Long-Term Memory.
Current biology : CB
Pavlowsky A,Schor J,Plaçais PY,Preat T
A-11122 was used in Immunohistochemistry to propose that this dual-receptor feedback supports a bidirectional self-regulation of MP1 input to the MB.
Mon Jun 04 00:00:00 UTC 2018
Circadian Waves of Transcriptional Repression Shape PIF-Regulated Photoperiod-Responsive Growth in Arabidopsis.
Current biology : CB
Martín G,Rovira A,Veciana N,Soy J,Toledo-Ortiz G,Gommers CMM,Boix M,Henriques R,Minguet EG,Alabadí D,Halliday KJ,Leivar P,Monte E
A-11122 was used in Immunoprecipitation to provide a framework for recent TIMING OF CAB EXPRESSION 1 (TOC1/PRR1) data [5, 20] and reveal that the long described circadian morning-to-midnight waves of the PRR transcriptional repressors (PRR9, PRR7, PRR5, and TOC1) [21] jointly gate PIF activity to dawn to prevent overgrowth through sequential regulation of common PIF-PRR target genes such as CDF5.
Mon Jan 22 00:00:00 UTC 2018
Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila.
Current biology : CB
Sparvoli D,Richardson E,Osakada H,Lan X,Iwamoto M,Bowman GR,Kontur C,Bourland WA,Lynn DH,Pritchard JK,Haraguchi T,Dacks JB,Turkewitz AP
A-11122 was used in Immunocytochemistry-immunoflourescence to underscore that biogenesis of mucocysts depends on endolysosomal trafficking, revealing parallels with invasive organelles in apicomplexan parasites and suggesting that a wide array of secretory adaptations in protists, like in animals, depend on mechanisms related to lysosome biogenesis.
Mon Mar 05 00:00:00 UTC 2018
Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis.
Arteriosclerosis, thrombosis, and vascular biology
Shi D,Qi M,Zhou L,Li X,Ni L,Li C,Yuan T,Wang Y,Chen Y,Hu C,Liang D,Li L,Liu Y,Li J,Chen YH
A-11122 was used in Immunohistochemistry to study Tomm7 in driving brain angiogenesis and cerebrovascular network formation via mitochondrial signalling modulation.
Thu Nov 01 00:00:00 UTC 2018
Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain.
Molecular therapy. Nucleic acids
Fukuoka M,Takahashi M,Fujita H,Chiyo T,Popiel HA,Watanabe S,Furuya H,Murata M,Wada K,Okada T,Nagai Y,Hohjoh H
A-11122 was used in Immunohistochemistry-immunofluorescence to show amelioration in motor function and lifespan of Huntington's disease (HD)-model mice, R6/2 mice, by supplying miR-132 to HD brains using a recombinant adeno-associated virus (rAAV) miRNA expression system.
Fri Jun 01 00:00:00 UTC 2018
Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity.
PLoS biology
Cerrato V,Parmigiani E,Figueres-Oñate M,Betizeau M,Aprato J,Nanavaty I,Berchialla P,Luzzati F,de'Sperati C,López-Mascaraque L,Buffo A
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that the major cerebellar astrocyte types emerge according to an unprecedented and remarkably orderly developmental program.
Sat Sep 01 00:00:00 UTC 2018
Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
PLoS biology
Ménard M,Costechareyre C,Ichim G,Blachier J,Neves D,Jarrosson-Wuilleme L,Depping R,Koster J,Saintigny P,Mehlen P,Tauszig-Delamasure S
A-11122 was used in Immunoprecipitation to demonstrate that Hey1 and TrkC-KF transcriptionally silence mouse double minute 2 homolog (MDM2), thus contributing to p53 stabilization.
Tue May 01 00:00:00 UTC 2018
Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition.
PLoS biology
Seller CA,O'Farrell PH
A-11122 was used in Immunohistochemistry to shows that Rif1 and S phase kinases compose a replication timer controlling first the developmental onset of late replication and then the precise schedule of replication within S phase.
Tue May 01 00:00:00 UTC 2018
Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT.
Science signaling
Vachel L,Shcheynikov N,Yamazaki O,Fremder M,Ohana E,Son A,Shin DM,Yamazaki-Nakazawa A,Yang CR,Knepper MA,Muallem S
A-11122 was used in Immunoprecipitation to reveal how multiple kinase and phosphatase pathways use phosphorylation sites to fine-tune a transporter which has important implications for epithelial fluid and HCO3- secretion.
Tue Oct 30 00:00:00 UTC 2018
Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice.
British journal of pharmacology
Ozawa A,Brunori G,Cippitelli A,Toll N,Schoch J,Kieffer BL,Toll L
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the peripheral and spinal NOP receptor distribution and antinociceptive effects of intrathecal nociceptin/orphanin FQ (N/OFQ) in chronic neuropathic pain.
Sun Jul 01 00:00:00 UTC 2018
RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity.
Cellular and molecular life sciences : CMLS
Trixl L,Amort T,Wille A,Zinni M,Ebner S,Hechenberger C,Eichin F,Gabriel H,Schoberleitner I,Huang A,Piatti P,Nat R,Troppmair J,Lusser A
A-11122 was used in Immunocytochemistry-immunoflourescence to not only characterize Nsun3 as an important regulator of stem cell fate but also provide a model system to study the still incompletely understood interplay of mitochondrial function with stem cell pluripotency and differentiation.
Sun Apr 01 00:00:00 UTC 2018
Functional interplay between c-Myc and Max in B lymphocyte differentiation.
EMBO reports
Pérez-Olivares M,Trento A,Rodriguez-Acebes S,González-Acosta D,Fernández-Antorán D,Román-García S,Martinez D,López-Briones T,Torroja C,Carrasco YR,Méndez J,Moreno de Alborán I
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation.
Mon Oct 01 00:00:00 UTC 2018
Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes.
EMBO reports
Shakya S,Sharma P,Bhatt AM,Jani RA,Delevoye C,Setty SR
A-11122 was used in Western Blotting to suggest that Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on E/SEs to generate REs that maintain cellular and organelle homeostasis.
Sat Dec 01 00:00:00 UTC 2018
Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis.
The Journal of cell biology
Funabashi T,Katoh Y,Okazaki M,Sugawa M,Nakayama K
A-11122 was used in Western Blotting to determine the molecular basis of trafficking of intraflagellar transport particles regulated by kinesin and dynein motors.
Mon Aug 06 00:00:00 UTC 2018
Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers.
The Journal of cell biology
Ripoll L,Heiligenstein X,Hurbain I,Domingues L,Figon F,Petersen KJ,Dennis MK,Houdusse A,Marks MS,Raposo G,Delevoye C
A-11122 was used in Immunomicroscopy to study the mechanism underlying organelle function.
Mon Aug 06 00:00:00 UTC 2018
KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth.
The Journal of cell biology
Xu F,Takahashi H,Tanaka Y,Ichinose S,Niwa S,Wicklund MP,Hirokawa N
A-11122 was used in Immunoprecipitation to show that the receptor tyrosine kinase IGF1R is a new direct binding partner of KIF1Bβ and its binding and transport is specifically impaired by the Y1087C mutation of KIF1Bβ when detected in hereditary neuropathic patients.
Mon Oct 01 00:00:00 UTC 2018
KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth.
The Journal of cell biology
Xu F,Takahashi H,Tanaka Y,Ichinose S,Niwa S,Wicklund MP,Hirokawa N
A-11122 was used in Immunoprecipitation to show that the receptor tyrosine kinase IGF1R is a new direct binding partner of KIF1Bβ and its binding and transport is specifically impaired by the Y1087C mutation of KIF1Bβ when detected in hereditary neuropathic patients.
Mon Oct 01 00:00:00 UTC 2018
Spatiotemporal organization of exocytosis emerges during neuronal shape change.
The Journal of cell biology
Urbina FL,Gomez SM,Gupton SL
A-11122 was used in Immunoprecipitation to exploit total internal reflection fluorescence microscopy to image vesicle-associated membrane protein (VAMP)-pHluorin-mediated exocytosis in mouse embryonic cortical neurons and interphase melanoma cells, and develop computer-vision software and statistical tools to uncover spatiotemporal aspects of exocytosis.
Mon Mar 05 00:00:00 UTC 2018
ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway.
Neurobiology of disease
Ka M,Kim WY
A-11122 was used in Immunohistochemistry to study the neurological role of ANKRD11 during brain development.
Thu Mar 01 00:00:00 UTC 2018
Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse.
Development (Cambridge, England)
Montague TG,Gagnon JA,Schier AF
A-11122 was used in Western Blotting to demonstrate conservation between zebrafish and mouse mechanisms of left-right patterning.
Mon Dec 10 00:00:00 UTC 2018
BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation.
Development (Cambridge, England)
Jardin N,Giudicelli F,Ten Martín D,Vitrac A,De Gois S,Allison R,Houart C,Reid E,Hazan J,Fassier C
A-11122 was used in Immunohistochemistry to determine the roles of BMP and neuropilin-1 in neuronal development and homeostasis.
Wed Sep 12 00:00:00 UTC 2018
The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye.
Development (Cambridge, England)
Duan H,de Navas LF,Hu F,Sun K,Mavromatakis YE,Viets K,Zhou C,Kavaler J,Johnston RJ,Tomlinson A,Lai EC
A-11122 was used in Immunohistochemistry-immunofluorescence to study photoreceptors in the Drosophila eye and report on the involvement of miR-279/996 for its control.
Mon Apr 09 00:00:00 UTC 2018
A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.
Development (Cambridge, England)
Han S,Dennis DJ,Balakrishnan A,Dixit R,Britz O,Zinyk D,Touahri Y,Olender T,Brand M,Guillemot F,Kurrasch D,Schuurmans C
A-11122 was used in Immunohistochemistry to study the interactions bwteen Neurog 1 and Neurog 2 in the control of neocortical neurogenesis.
Mon Oct 01 00:00:00 UTC 2018
Krox20 defines a subpopulation of cardiac neural crest cells contributing to arterial valves and bicuspid aortic valve.
Development (Cambridge, England)
Odelin G,Faure E,Coulpier F,Di Bonito M,Bajolle F,Studer M,Avierinos JF,Charnay P,Topilko P,Zaffran S
A-11122 was used in Immunohistochemistry to demonstrate a crucial role for Krox20 in arterial valve development.
Wed Jan 03 00:00:00 UTC 2018
Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
Development (Cambridge, England)
Yamashita W,Takahashi M,Kikkawa T,Gotoh H,Osumi N,Ono K,Nomura T
A-11122 was used in Immunohistochemistry to suggest that spatiotemporal changes in Pax6-dependent regulatory programs contributed to species-specific neurogenic patterns in mammalian and avian lineages, which underlie the morphological divergence of the amniote pallial architectures.
Mon Apr 16 00:00:00 UTC 2018
Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.
Development (Cambridge, England)
Baker LR,Weasner BM,Nagel A,Neuman SD,Bashirullah A,Kumar JP
A-11122 was used in Immunohistochemistry to reveal an unexpected mechanism for how Pax6 controls eye development in Drosophila.
Thu Aug 02 00:00:00 UTC 2018
Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yuan L,Liang TY,Deng J,Sun YG
A-11122 was used in Immunohistochemistry to reveal a potential target for suppressing excessive scratching responses in patients with chronic itch.
Wed Nov 14 00:00:00 UTC 2018
Schaffer Collateral Inputs to CA1 Excitatory and Inhibitory Neurons Follow Different Connectivity Rules.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kwon O,Feng L,Druckmann S,Kim J
A-11122 was used in Immunohistochemistry to better understand hippocampal networks by providing new evidence for differently structured connectivity at a fine scale in hippocampal excitatory and inhibitory neurons.
Wed May 30 00:00:00 UTC 2018
Brain Circuits Mediating Opposing Effects on Emotion and Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cai YQ,Wang W,Paulucci-Holthauzen A,Pan ZZ
A-11122 was used in Immunohistochemistry to investigate how the amygdala circuits regulate negative and positive emotions, such as depression and anxiety induced by chronic pain.
Wed Jul 11 00:00:00 UTC 2018
Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dresselhaus EC,Boersma MCH,Meffert MK
A-11122 was used in Western Blotting to support spatial localization at synapses as a key variable mediating selective stimulus-response coupling.
Wed Apr 25 00:00:00 UTC 2018
An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4.
The Journal of neuroscience : the official journal of the Society for Neuroscience
van Battum EY,Verhagen MG,Vangoor VR,Fujita Y,Derijck AAHA,O'Duibhir E,Giuliani G,de Gunst T,Adolfs Y,Lelieveld D,Egan D,Schaapveld RQJ,Yamashita T,Pasterkamp RJ
A-11122 was used in Immunocytochemistry to identify a novel neuronal role for miR-135s and the miR-135-KLF4 pathway and highlight the potential of miRNAs as tools for enhancing CNS axon regeneration in mice.
Wed Jan 17 00:00:00 UTC 2018
Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin.
Frontiers in cell and developmental biology
Blechman J,Anbalagan S,Matthews GG,Levkowitz G
A-11122 was used in Immunohistochemistry to determine the role of CNGA2 in oxytocin neurons function.
Thu Oct 01 00:00:00 UTC 2020
An Indispensable Role of Androgen Receptor in Wnt Responsive Cells During Prostate Development, Maturation, and Regeneration.
Stem cells (Dayton, Ohio)
He Y,Hooker E,Yu EJ,Wu H,Cunha GR,Sun Z
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate an indispensable role for the Ar in Wnt-responsive cells during the course of prostate development, morphogenesis, and regeneration, which also imply an underlying interaction between the androgen and Wnt signaling pathways in the mouse prostate.
Fri Jun 01 00:00:00 UTC 2018
Notch Signaling Regulates Lgr5+ Olfactory Epithelium Progenitor/Stem Cell Turnover and Mediates Recovery of Lesioned Olfactory Epithelium in Mouse Model.
Stem cells (Dayton, Ohio)
Dai Q,Duan C,Ren W,Li F,Zheng Q,Wang L,Li W,Lu X,Ni W,Zhang Y,Chen Y,Wen T,Yu Y,Yu H
A-11122 was used in Immunocytochemistry-immunofluorescence to report that leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is expressed in globose basal cells (GBCs) localized in OE.
Wed Aug 01 00:00:00 UTC 2018
Hierarchical Control of Drosophila Sleep, Courtship, and Feeding Behaviors by Male-Specific P1 Neurons.
Neuroscience bulletin
Zhang W,Guo C,Chen D,Peng Q,Pan Y
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate how a set of male-specific P1 neurons controls sleep, courtship, and feeding behaviors in Drosophila males.
Sat Dec 01 00:00:00 UTC 2018
Stress granule formation is induced by a threshold temperature rather than a temperature difference in Arabidopsis.
Journal of cell science
Hamada T,Yako M,Minegishi M,Sato M,Kamei Y,Yanagawa Y,Toyooka K,Watanabe Y,Hara-Nishimura I
A-11122 was used in Immunomicroscopy to provide new insights into the universal nature of stress granules in eukaryotic cells.
Mon Aug 20 00:00:00 UTC 2018
Puf3 participates in ribosomal biogenesis in malaria parasites.
Journal of cell science
Liang X,Hart KJ,Dong G,Siddiqui FA,Sebastian A,Li X,Albert I,Miao J,Lindner SE,Cui L
A-11122 was used in Immunocytochemistry to characterize the Puf family gene member Puf3 in the malaria parasites Plasmodium falciparum and Plasmodium yoelii.
Mon Mar 26 00:00:00 UTC 2018
LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.
Journal of cell science
Tseng HY,Samarelli AV,Kammerer P,Scholze S,Ziegler T,Immler R,Zent R,Sperandio M,Sanders CR,Fässler R,Böttcher RT
A-11122 was used in Flow cytometry/Cell sorting to offer a global view on cytoplasmic proteins interacting with different integrins and provide evidence for the existence of conformation-specific integrin interactors.
Wed Nov 21 00:00:00 UTC 2018
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.
Journal of cell science
Ghosh S,Scozzaro S,Ramos AR,Delcambre S,Chevalier C,Krejci P,Erneux C
A-11122 was used in Immunohistochemistry-immunofluorescence to determine the role of SHIP2 in cell migration in breast cancer cells.
Thu Aug 16 00:00:00 UTC 2018
Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes.
Journal of cell science
Otero MG,Fernandez Bessone I,Hallberg AE,Cromberg LE,De Rossi MC,Saez TM,Levi V,Almenar-Queralt A,Falzone TL
A-11122 was used in Western Blotting to study the effect of proteasome activity on the regulation of axonal transport and metabolism on the amyloid precursor protein (APP).
Mon Jun 11 00:00:00 UTC 2018
Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.
Journal of cell science
Singh V,Yang J,Yin J,Cole R,Tse M,Berman DE,Small SA,Petsko G,Donowitz M
A-11122 was used in Western Blotting to study the mechanisms by which cholera toxin inhibits NHE3.
Fri Aug 17 00:00:00 UTC 2018
Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription.
Journal of cell science
Rubio A,García-Blanco N,Vázquez-Bolado A,Belén Suárez M,Moreno S
A-11122 was used in Western Blotting to compare the phenotypes of cells lacking Rum1 and the anaphase-promoting complex/cyclosome (APC/C) activator Ste9 in nitrogen-rich and nitrogen-poor media.
Thu Sep 20 00:00:00 UTC 2018
Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles.
Journal of cell science
Nag S,Rani S,Mahanty S,Bissig C,Arora P,Azevedo C,Saiardi A,van der Sluijs P,Delevoye C,van Niel G,Raposo G,Setty SRG
A-11122 was used in Western Blotting to demonstrate Rab4A acts a key regulator of cargo segregation on SEs.
Thu Sep 20 00:00:00 UTC 2018
Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Journal of cell science
Ayala CI,Kim J,Neufeld TP
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that Rab6 acts to maintain the reciprocal regulation between autophagy and TOR activity during distinct nutrient states, thereby balancing autophagosome production and turnover to avoid autophagic stress.
Fri Sep 07 00:00:00 UTC 2018
Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Journal of cell science
Ayala CI,Kim J,Neufeld TP
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that Rab6 acts to maintain the reciprocal regulation between autophagy and TOR activity during distinct nutrient states, thereby balancing autophagosome production and turnover to avoid autophagic stress.
Fri Sep 07 00:00:00 UTC 2018
Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.
Journal of cell science
Falk N,Kessler K,Schramm SF,Boldt K,Becirovic E,Michalakis S,Regus-Leidig H,Noegel AA,Ueffing M,Thiel CT,Roepman R,Brandstätter JH,Gießl A
A-11122 was used in Immunocytochemistry to reveal the essential interaction between Pericentrin (Pcnt) and Syne-2 during ciliogenesis in photoreceptors of mouse retina.
Fri Aug 17 00:00:00 UTC 2018
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches.
Cell cycle (Georgetown, Tex.)
Rhodes CT,Zunino G,Huang SA,Cardona SM,Cardona AE,Berger MS,Lemmon VP,Lin CA
A-11122 was used in Flow cytometry/Cell sorting to identify the distinct roles of chromatin modifiers in adult neurogenic niches.
Fri Sep 06 00:00:00 UTC 2019
Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Human molecular genetics
Matsumoto T,Matsukawa K,Watanabe N,Kishino Y,Kunugi H,Ihara R,Wakabayashi T,Hashimoto T,Iwatsubo T
A-11122 was used in Western Blotting to study the molecular mechanism by which fused in sarcoma protein causes neurodegeneration.
Sun Apr 15 00:00:00 UTC 2018
The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression.
Molecular and cellular biology
Blanch M,Dorca-Arévalo J,Not A,Cases M,Gómez de Aranda I,Martínez-Yélamos A,Martínez-Yélamos S,Solsona C,Blasi J
A-11122 was used in Western Blotting to show that Etx selectively recognises and kills only human cell lines expressing myelin and lymphocyte protein through a direct Etx-MAL protein interaction.
Mon Oct 01 00:00:00 UTC 2018
Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells.
Endocrinology
Prasasya RD,Mayo KE
A-11122 was used in Immunohistochemistry to reveal a role of Notch signaling in promoting the differentiation of preovulatory granulosa cells.
Mon Jan 01 00:00:00 UTC 2018
The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration.
Investigative ophthalmology & visual science
Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL
A-11122 was used in Immunohistochemistry to reveal that Krüppel-Like Factor 9 (KLF9) drives the expression of dual specific phosphatase-14 (Dusp14) which regulates survival and axon regeneration after optic nerve injury.
Fri Jun 01 00:00:00 UTC 2018
A stochastic framework to model axon interactions within growing neuronal populations.
PLoS computational biology
Razetti A,Medioni C,Malandain G,Besse F,Descombes X
A-11122 was used in Immunohistochemistry-immunofluorescence to develop a stochastic model of 3D axon growth that takes into account spatial environmental constraints, physical interactions between neighbouring axons and branch formation.
Sat Dec 01 00:00:00 UTC 2018
Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice.
Psychopharmacology
Hideshima KS,Hojati A,Saunders JM,On DM,de la Fuente Revenga M,Shin JM,Sánchez-González A,Dunn CM,Pais AB,Pais AC,Miles MF,Wolstenholme JT,González-Maeso J
A-11122 was used in Immunohistochemistry to test antipsychotic-like behavioural phenotypes induced by the atypical antipsychotic clozapine in mGlu2-KO mice and wild-type control littermates.
Thu Nov 01 00:00:00 UTC 2018
Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster.
Molecules and cells
Yu KE,Kim DH,Kim YI,Jones WD,Lee JE
A-11122 was used in Western Blotting to characterise the Orco interactome from Drosophila melanogaster using mass spectrometry screening.
Wed Feb 28 00:00:00 UTC 2018
The O-GlcNAc transferase OGT interacts with and post-translationally modifies the transcription factor HOXA1.
FEBS letters
Draime A,Bridoux L,Belpaire M,Pringels T,Degand H,Morsomme P,Rezsohazy R
A-11122 was used in Immunocytochemistry-immunoflourescence to reveal distinct partner proteins interacting with HOXA1.
Sun Apr 01 00:00:00 UTC 2018
Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO).
Experimental eye research
Wang Y,Mahesh P,Wang Y,Novo SG,Shihan MH,Hayward-Piatkovskyi B,Duncan MK
A-11122 was used in Immunohistochemistry to understand the distribution of canonical Wnt signalling during embryonic eye development and posterior capsular opacification.
Mon Oct 01 00:00:00 UTC 2018
The circadian gene Nr1d1 in the mouse nucleus accumbens modulates sociability and anxiety-related behaviour.
The European journal of neuroscience
Zhao C,Gammie SC
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that Nr1d1 in the NAc modulates sociability and anxiety-related behaviour in a sex-specific manner, and circadian, histone deacetylase and opioid-related genes may be involved in the expression of these behavioural phenotypes.
Wed Aug 01 00:00:00 UTC 2018
Rap1 GTPase promotes coordinated collective cell migration in vivo.
Molecular biology of the cell
Sawant K,Chen Y,Kotian N,Preuss KM,McDonald JA
A-11122 was used in Immunohistochemistry-immunofluorescence to propose that precisely regulated Rap1 activity reinforces connections between cells and polarizes the cluster, thus facilitating the coordinated collective migration of border cells.
Thu Nov 01 00:00:00 UTC 2018
Lipid biosensor interactions with wild type and matrix deletion HIV-1 Gag proteins.
Virology
Barklis E,Staubus AO,Mack A,Harper L,Barklis RL,Alfadhli A
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate an approach to the analysis of viral protein-lipid associations and provide data on the lipid compositions of HIV-1 assembly sites.
Tue May 01 00:00:00 UTC 2018
Retinoic acid temporally orchestrates colonization of the gut by vagal neural crest cells.
Developmental biology
Uribe RA,Hong SS,Bronner ME
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that retinoic acid plays a critical temporal role in promoting enteric neural crest chain migration and neuronal survival upstream of Meis3 and RET in vivo.
Mon Jan 01 00:00:00 UTC 2018
Maternal Nanos-Dependent RNA Stabilization in the Primordial Germ Cells of Drosophila Embryos.
Development, growth & differentiation
Sugimori S,Kumata Y,Kobayashi S
A-11122 was used in Immunohistochemistry-immunofluorescence to find that the level of mRNA expressed from a reporter gene fused to the CG32425 3' UTR was significantly reduced in PGCs lacking maternal Nos (nos PGCs) as compared with normal PGCs.
Mon Jan 01 00:00:00 UTC 2018
Imaging pathological activities of human brain tissue in organotypic culture.
Journal of neuroscience methods
Le Duigou C,Savary E,Morin-Brureau M,Gomez-Dominguez D,Sobczyk A,Chali F,Milior G,Kraus L,Meier JC,Kullmann DM,Mathon B,de la Prida LM,Dorfmuller G,Pallud J,Eugène E,Clemenceau S,Miles R
A-11122 was used in Immunohistochemistry-immunofluorescence to show that organotypic culture techniques can be used to maintain brain tissue from patients with neurological syndromes for several weeks in vitro.
Thu Mar 15 00:00:00 UTC 2018
larvalign: Aligning Gene Expression Patterns from the Larval Brain of Drosophila melanogaster.
Neuroinformatics
Muenzing SEA,Strauch M,Truman JW,Bühler K,Thum AS,Merhof D
A-11122 was used in Immunohistochemistry-immunofluorescence to provide a manually annotated gold standard that serves for evaluation of the registration framework involved in template generation and mapping.
Mon Jan 01 00:00:00 UTC 2018
In vivo analyses of radial spoke transport, assembly, repair and maintenance.
Cytoskeleton (Hoboken, N.J.)
Lechtreck KF,Mengoni I,Okivie B,Hilderhoff KB
A-11122 was used in Western Blotting to study radial spokes dynamics in vivo.
Wed Aug 01 00:00:00 UTC 2018
Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers.
Developmental dynamics : an official publication of the American Association of Anatomists
Ogawa T,Li Y,Lua I,Hartner A,Asahina K
A-11122 was used in Immunohistochemistry to identify specific markers for embryonic hepatic stellate cells.
Fri Jun 01 00:00:00 UTC 2018
Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens.
Developmental dynamics : an official publication of the American Association of Anatomists
Martynova E,Bouchard M,Musil LS,Cvekl A
A-11122 was used in Immunocytochemistry-immunoflourescence to identify a novel distal enhancer of Gata3 with high activity in lens and indicate that BMP and FGF signaling can up-regulate expression of Gata3 in differentiating lens fiber cells through the identified Gata3 enhancer and promoter elements.
Thu Nov 01 00:00:00 UTC 2018
Structure of vagal afferent nerve terminal fibers in the mouse trachea.
Respiratory physiology & neurobiology
Hennel M,Harsanyiova J,Ru F,Zatko T,Brozmanova M,Trancikova A,Tatar M,Kollarik M
A-11122 was used in Immunohistochemistry-wholemount to aid the study of structure-function relationships in vagal airway afferent nerves and regulation of respiratory reflexes.
Thu Feb 01 00:00:00 UTC 2018
Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions.
eLife
Klug JR,Engelhardt MD,Cadman CN,Li H,Smith JB,Ayala S,Williams EW,Hoffman H,Jin X
A-11122 was used in Immunohistochemistry to establish the brain-wide direct inputs of two major types of striatal interneurons and allude to distinct roles in regulating striatal activity and controlling behavior.
Tue May 01 00:00:00 UTC 2018
A sleep state in Drosophila larvae required for neural stem cell proliferation.
eLife
Szuperak M,Churgin MA,Borja AJ,Raizen DM,Fang-Yen C,Kayser MS
A-11122 was used in Immunohistochemistry to identify a sleep state in Drosophila larvae as a critical factor for normal proliferation of neural stem cells.
Fri Feb 09 00:00:00 UTC 2018
Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
McIntosh DJ,Walters TS,Arinze IJ,Davis J
A-11122 was used in Western Blotting to study the role of second mammalian STUbL, Arkadia/RNF111 on Nrf2.
Mon Jun 25 00:00:00 UTC 2018
The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent.
PloS one
Ferguson R,Subramanian V
A-11122 was used in Immunohistochemistry to shed light on why mutations which do not overtly affect RNase activity but cause impaired localization are associated with neurodegenerative disease.
Wed May 23 00:00:00 UTC 2018
PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2.
Neuron
Duan L,Zhang XD,Miao WY,Sun YJ,Xiong G,Wu Q,Li G,Yang P,Yu H,Li H,Wang Y,Zhang M,Hu LY,Tong X,Zhou WH,Yu X
A-11122 was used in Western Blotting to show that within 2 hr of systemic inflammation, PDGFRβ mural cells of blood vessels rapidly secrete chemokine CCL2, which in turn increases total neuronal excitability by promoting excitatory synaptic transmission in glutamatergic neurons of multiple brain regions.
Wed Oct 10 00:00:00 UTC 2018
Adult-specific insulin-producing neurons in Drosophila melanogaster.
The Journal of comparative neurology
Ohhara Y,Kobayashi S,Yamakawa-Kobayashi K,Yamanaka N
A-11122 was used in Immunohistochemistry-immunofluorescence to provide a neuroanatomical basis for understanding remodeling of the neuropeptidergic system during insect development and evolution.
Fri Jun 01 00:00:00 UTC 2018
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.
Cell
Li Y,Schnabl K,Gabler SM,Willershäuser M,Reber J,Karlas A,Laurila S,Lahesmaa M,U Din M,Bast-Habersbrunner A,Virtanen KA,Fromme T,Bolze F,O'Farrell LS,Alsina-Fernandez J,Coskun T,Ntziachristos V,Nuutila P,Klingenspor M
A-11122 was used in In vivo experiments to highlight the largely unappreciated function of brown fat meal-associated brown fat (BAT) thermogenesis BAT in the control of satiation and qualify BAT as an even more attractive target for treating obesity.
Thu Nov 29 00:00:00 UTC 2018
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.
Nature communications
Charles-Orszag A,Tsai FC,Bonazzi D,Manriquez V,Sachse M,Mallet A,Salles A,Melican K,Staneva R,Bertin A,Millien C,Goussard S,Lafaye P,Shorte S,Piel M,Krijnse-Locker J,Brochard-Wyart F,Bassereau P,Duménil G
A-11122 was used in Immunocytochemistry to show the effect of bacterial pathogens on the shape of cellular membranes in bacterium like Neisseria meningitidis.
Thu Oct 25 00:00:00 UTC 2018
Cell Type-Specific Profiling of Chromatin Modifications and Associated Proteins.
Methods in molecular biology (Clifton, N.J.)
Morao AK,Caillieux E,Colot V,Roudier F
A-11122 was used in Immunohistochemistry-immunofluorescence to describe a chromatin immunoprecipitation protocol that has been successfully used to profile histone modifications and other chromatin-associated proteins such as RNA Polymerase II in different cell populations of the Arabidopsis root, including the quiescent center of the stem cell niche.
Mon Jun 04 00:00:00 UTC 2018
Chromatin remodeling factor CHR18 interacts with replication protein RPA1A to regulate the DNA replication stress response in Arabidopsis.
The New phytologist
Han JJ,Song ZT,Sun JL,Yang ZT,Xian MJ,Wang S,Sun L,Liu JX
A-11122 was used in Western Blotting to demonstrate that during DNA synthesis in plants, RPA1A interacts with CHR18 and recruits CHR18 to nuclear foci to resolve DNA replication stress, which is important for cell propagation and root growth in Arabidopsis plants.
Mon Oct 01 00:00:00 UTC 2018
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Autophagy
Onnis A,Cianfanelli V,Cassioli C,Samardzic D,Pelicci PG,Cecconi F,Baldari CT
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to identify mitochondrial p66SHC as a novel regulator of autophagy and mitophagy in B cells and implicate p66SHC-mediated coordination of autophagy and apoptosis in B cell survival and differentiation.
Tue Oct 22 00:00:00 UTC 2019
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Autophagy
Onnis A,Cianfanelli V,Cassioli C,Samardzic D,Pelicci PG,Cecconi F,Baldari CT
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation to identify mitochondrial p66SHC as a novel regulator of autophagy and mitophagy in B cells and implicate p66SHC-mediated coordination of autophagy and apoptosis in B cell survival and differentiation.
Tue Oct 22 00:00:00 UTC 2019
Mouse Satellite Cell Isolation and Transplantation.
Bio-protocol
Angelino E,Reano S,Ferrara M,Agosti E,Sustova H,Malacarne V,Clerici S,Graziani A,Filigheddu N
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate satellite cell transplantation.
Sat Jan 20 00:00:00 UTC 2018
Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.
Nature communications
Faget L,Zell V,Souter E,McPherson A,Ressler R,Gutierrez-Reed N,Yoo JH,Dulcis D,Hnasko TS
A-11122 was used in Immunohistochemistry to findings highlight cell-type and projection-target specific roles for VP neurons in behavioral reinforcement, dysregulation of which could contribute to the emergence of negative symptoms associated with drug addiction and other neuropsychiatric disease.
Tue Feb 27 00:00:00 UTC 2018
Ultrastructural analysis of mitotic Drosophila S2 cells identifies distinctive microtubule and intracellular membrane behaviors.
BMC biology
Strunov A,Boldyreva LV,Andreyeva EN,Pavlova GA,Popova JV,Razuvaeva AV,Anders AF,Renda F,Pindyurin AV,Gatti M,Kiseleva E
A-11122 was used in Immunocytochemistry-immunoflourescence to provide a detailed characterization of all phases of S2 cell mitosis visualized by transmission electron microscopy (TEM).
Fri Jun 15 00:00:00 UTC 2018
Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.
PLoS genetics
Arbeille E,Bashaw GJ
A-11122 was used in Immunohistochemistry-immunofluorescence to define a new mechanism in the coordination of axon growth and guidance at the midline.
Sun Apr 01 00:00:00 UTC 2018
Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
Nature communications
Wang C,Kang X,Zhou L,Chai Z,Wu Q,Huang R,Xu H,Hu M,Sun X,Sun S,Li J,Jiao R,Zuo P,Zheng L,Yue Z,Zhou Z
A-11122 was used in Western Blotting to show that synaptotagmin-11 encoded by a Parkinson's disease risk gene SYT11 is a physiological substrate of parkin and plays critical roles in mediating parkin-linked neurotoxicity.
Mon Jan 08 00:00:00 UTC 2018
A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila.
Stem cell reports
Yin C,Xi R
A-11122 was used in Immunocytochemistry-immunoflourescence to develop an understanding as to how Phyllopod causes intestinal stem cells in Drosophila differentiate into enteroendocrine cells via alternative cell fate speciation.
Tue Jan 09 00:00:00 UTC 2018
The functional organization of descending sensory-motor pathways in Drosophila.
eLife
Namiki S,Dickinson MH,Wong AM,Korff W,Card GM
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal the basic functional map of descending pathways in flies and provide tools for systematic interrogation of neural circuits.
Tue Jun 26 00:00:00 UTC 2018
Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses.
Scientific reports
Rodriguez-Duarte J,Dapueto R,Galliussi G,Turell L,Kamaid A,Khoo NKH,Schopfer FJ,Freeman BA,Escande C,Batthyány C,Ferrer-Sueta G,López GV
A-11122 was used in Immunohistochemistry-immunofluorescence to lay the foundation for the rational design of a new therapeutic strategy for the prevention and treatment of metabolic and inflammation-related diseases.
Fri Aug 24 00:00:00 UTC 2018
NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.
Nature communications
Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R
A-11122 was used in Immunoprecipitation to assess the molecular mechanism of NLRP3 inflammasome assembly in comparison to NLRC4.
Wed Dec 05 00:00:00 UTC 2018
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss.
Cell reports
Kosmidis S,Polyzos A,Harvey L,Youssef M,Denny CA,Dranovsky A,Kandel ER
A-11122 was used in Immunohistochemistry to explore the molecular mechanisms of RbAp48 function in the brain and its role in age-related memory loss.
Tue Oct 23 00:00:00 UTC 2018
Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons.
Cell reports
Hoyer N,Zielke P,Hu C,Petersen M,Sauter K,Scharrenberg R,Peng Y,Kim CC,Han C,Parrish JZ,Soba P
A-11122 was used in Immunohistochemistry to identify the substrate-derived TGF-Β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor.
Tue Aug 28 00:00:00 UTC 2018
Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.
Frontiers in neuroscience
Beck S,Yu-Strzelczyk J,Pauls D,Constantin OM,Gee CE,Ehmann N,Kittel RJ,Nagel G,Gao S
A-11122 was used in Immunohistochemistry to describe the engineering of novel light-gated Ca2+-permeant and K+-specific channels by fusing a bacterial photoactivated adenylyl cyclase to cyclic nucleotide-gated channels with high permeability for Ca2+ or for K+, respectively.
Tue Sep 29 00:00:00 UTC 2020
Striatal cholinergic interneurons regulate cognitive and affective dysfunction in partially dopamine-depleted mice.
The European journal of neuroscience
Ztaou S,Lhost J,Watabe I,Torromino G,Amalric M
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that dysfunction of the striatal cholinergic system may play a role in the short-term cognitive and emotional deficits of partially DA-depleted mice.
Thu Nov 01 00:00:00 UTC 2018
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
Nature communications
Incontro S,Díaz-Alonso J,Iafrati J,Vieira M,Asensio CS,Sohal VS,Roche KW,Bender KJ,Nicoll RA
A-11122 was used in Immunocytochemistry to delete CaMKII and replace it with mutated forms in single neurons using a CRISPR-based system, its various synaptic roles were addressed.
Fri May 25 00:00:00 UTC 2018
V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements.
Nature communications
Song J,Dahlberg E,El Manira A
A-11122 was used in Immunohistochemistry to identify how interneuron diversity is captured and transformed into a parsimonious task-specific circuit design controlling the vigor of locomotion.
Wed Aug 22 00:00:00 UTC 2018
Extension and refinement of the recognition motif for Toll-like receptor 5 activation by flagellin.
Journal of leukocyte biology
Ivičak-Kocjan K,Forstnerič V,Panter G,Jerala R,Benčina M
A-11122 was used in Western Blotting to demonstrate that flagellin is recognized by TLR5 through a more extensive interaction surface than previously characterized.
Mon Oct 01 00:00:00 UTC 2018
Efficient genome editing using CRISPR-Cas-mediated homology directed repair in the ascidian Ciona robusta.
Genesis (New York, N.Y. : 2000)
Pickett CJ,Zeller RW
A-11122 was used in Immunohistochemistry to show that biallelic FP-HDR template insertion can be detected in live embryos of the F0 generation.
Sat Dec 01 00:00:00 UTC 2018
Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses.
Cell reports
Besnard A,Langberg T,Levinson S,Chu D,Vicidomini C,Scobie KN,Dwork AJ,Arango V,Rosoklija GB,Mann JJ,Hen R,Leonardo ED,Boldrini M,Sahay A
A-11122 was used in Immunohistochemistry to show that Klf9 functions as a stress-responsive transcription factor that mediates circuit and behavioral resilience in a sex-specific manner.
Tue Jun 12 00:00:00 UTC 2018
Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.
Scientific reports
Zhang L,Willemse J,Hoskisson PA,van Wezel GP
A-11122 was used in Western Blotting to reveal a function for YlmD and YlmE in the control of sporulation-specific cell division in S. coelicolor, whereby the presence of YlmD alone results in major developmental defects.
Wed May 09 00:00:00 UTC 2018
Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway.
Cell reports
Jansz N,Nesterova T,Keniry A,Iminitoff M,Hickey PF,Pintacuda G,Masui O,Kobelke S,Geoghegan N,Breslin KA,Willson TA,Rogers K,Kay GF,Fox AH,Koseki H,Brockdorff N,Murphy JM,Blewitt ME
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate the involvement of Smchd1 to the PRC1 silencing pathway for X chromosome inactivation.
Tue Nov 13 00:00:00 UTC 2018
Hsp90 Mediates Membrane Deformation and Exosome Release.
Molecular cell
Lauwers E,Wang YC,Gallardo R,Van der Kant R,Michiels E,Swerts J,Baatsen P,Zaiter SS,McAlpine SR,Gounko NV,Rousseau F,Schymkowitz J,Verstreken P
A-11122 was used in Western Blotting to structurally separate the Hsp90 membrane-deforming function from its well-characterized chaperone activity, and show that this previously unrecognized function is required for exosome release.
Thu Sep 06 00:00:00 UTC 2018
Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons.
Nature communications
Weber F,Hoang Do JP,Chung S,Beier KT,Bikov M,Saffari Doost M,Dan Y
A-11122 was used in Immunohistochemistry-immunofluorescence to show that activating vlPAG GABAergic neurons in mice suppresses the initiation and maintenance of rapid eye movement sleep whilst consolidating non-REM sleep.
Wed Jan 24 00:00:00 UTC 2018
Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
PloS one
Toledo A,Grieger E,Karram K,Morrison H,Baader SL
A-11122 was used in Immunocytochemistry to study the role of Merlin in oligodendrocytes.
Mon Jul 30 00:00:00 UTC 2018
Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain.
The European journal of neuroscience
Ceredig RA,Pierre F,Doridot S,Alduntzin U,Salvat E,Yalcin I,Gaveriaux-Ruff C,Barrot M,Massotte D
A-11122 was used in Immunohistochemistry to establish a parallel between changes in the expression profile of peripheral DOP receptors and mechanical allodynia induced by sciatic nerve cuffing.
Sat Sep 01 00:00:00 UTC 2018
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.
Nature communications
Zhang L,Ip CK,Lee IJ,Qi Y,Reed F,Karl T,Low JK,Enriquez RF,Lee NJ,Baldock PA,Herzog H
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that NPFFR2 signalling promotes diet-induced thermogenesis via a novel hypothalamic NPY-dependent circuitry.
Fri Nov 09 00:00:00 UTC 2018
Promoting Myelin Repair through In Vivo Neuroblast Reprogramming.
Stem cell reports
El Waly B,Cayre M,Durbec P
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate the ability of neuroblasts, in the demyelination context, to spontaneously convert into myelinating oligodendrocytes.
Tue May 08 00:00:00 UTC 2018
A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kamijo S,Ishii Y,Horigane SI,Suzuki K,Ohkura M,Nakai J,Fujii H,Takemoto-Kimura S,Bito H
A-11122 was used in Western Blot to suggest that L-type VGCCs might constitute a perinatal therapeutic target for neurodevelopment-associated psychiatric disorders.
Wed Jun 13 00:00:00 UTC 2018
Homeodomain-interacting protein kinase phosphorylates the Drosophila Paired box protein 6 (Pax6) homologues Twin of eyeless and Eyeless.
Insect molecular biology
Steinmetz EL,Dewald DN,Walldorf U
A-11122 was used in Immunohistochemistry to suggest that interaction and phosphorylation of the master regulator Toy by Hipk may be important for precise tuning of signalling within the RDGN and therefore for Drosophila eye development.
Sun Apr 01 00:00:00 UTC 2018
Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.
The Journal of comparative neurology
Travers S,Breza J,Harley J,Zhu J,Travers J
A-11122 was used in Immunohistochemistry to suggest that cNST visceral signals exert stronger excitatory and inhibitory influences on local autonomic and reflex pathways associated with the medial and ventral subdivisions compared to weaker modulation of ascending pathways arising from the central subdivision and ultimately destined for the forebrain.
Mon Oct 01 00:00:00 UTC 2018
Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy.
Molecular therapy. Methods & clinical development
Rosales Gerpe MC,van Vloten JP,Santry LA,de Jong J,Mould RC,Pelin A,Bell JC,Bridle BW,Wootton SK
A-11122 was used in Immunohistochemistry to test.
Fri Sep 21 00:00:00 UTC 2018
An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila.
eLife
Li-Kroeger D,Kanca O,Lee PT,Cowan S,Lee MT,Jaiswal M,Salazar JL,He Y,Zuo Z,Bellen HJ
A-11122 was used in Immunohistochemistry-immunofluorescence to generate two new genetic tools to efficiently tag genes in Drosophila, allowing precise gene manipulation and facilitate detection of gene expression, protein localisation and assessment of protein function.
Thu Aug 09 00:00:00 UTC 2018
Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.
Science advances
Castle MJ,Cheng Y,Asokan A,Tuszynski MH
A-11122 was used in Immunohistochemistry to provide a novel and simple method for broad gene delivery to the cortex and are of substantial relevance to translational programs for neurological disorders like Alzheimer's disease and stroke.
Thu Nov 01 00:00:00 UTC 2018
A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.
Molecular therapy. Methods & clinical development
Wang D,Li S,Gessler DJ,Xie J,Zhong L,Li J,Tran K,Van Vliet K,Ren L,Su Q,He R,Goetzmann JE,Flotte TR,Agbandje-McKenna M,Gao G
A-11122 was used in Immunohistochemistry-immunofluorescence to study AAV capsid sequence-structure-function relationship to further improve vector targeting and expand the vector toolbox for therapeutic gene delivery.
Fri Jun 15 00:00:00 UTC 2018
Inflammation-associated changes in DOR expression and function in the mouse colon.
American journal of physiology. Gastrointestinal and liver physiology
DiCello JJ,Saito A,Rajasekhar P,Eriksson EM,McQuade RM,Nowell CJ,Sebastian BW,Fichna J,Veldhuis NA,Canals M,Bunnett NW,Carbone SE,Poole DP
A-11122 was used in Immunohistochemistry to demonstrate that active delta opioid receptors inhibit colonic motility and are enhanced during inflammation.
Mon Oct 01 00:00:00 UTC 2018
Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells.
Nature communications
Misra A,Feng Z,Chandran RR,Kabir I,Rotllan N,Aryal B,Sheikh AQ,Ding L,Qin L,Fernández-Hernando C,Tellides G,Greif DM
A-11122 was used in Immunohistochemistry to study the mechanisms regulating expansion and fate of pre-existing smooth muscle cells in atherosclerotic plaques.
Fri May 25 00:00:00 UTC 2018
Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
Cell reports
Prasad N,Hens K
A-11122 was used in Immunohistochemistry to determine that the Scarface serine protease homolog mediates the hedonic control of feeding in Drosophila.
Tue Sep 18 00:00:00 UTC 2018
The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.
Immunity
Pelka K,Bertheloot D,Reimer E,Phulphagar K,Schmidt SV,Christ A,Stahl R,Watson N,Miyake K,Hacohen N,Haas A,Brinkmann MM,Marshak-Rothstein A,Meissner F,Latz E
A-11122 was used in Immunocytochemistry to report that UNC93B1 regulates a step upstream of the differential TLR trafficking process.
Tue May 15 00:00:00 UTC 2018
Somatotopic organization of central arbors from nociceptive afferents develops independently of their intact peripheral target innervation.
The Journal of comparative neurology
Olson W,Luo W
A-11122 was used in Immunohistochemistry to establish this somatotopic difference.
Sat Dec 15 00:00:00 UTC 2018
Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.
Cell reports
Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W
A-11122 was used in Immunohistochemistry to identify a developmental mechanism specifically required for long-range spinal cord longitudinal axons.
Tue Jun 05 00:00:00 UTC 2018
Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes.
eLife
Salinas-Hernández XI,Vogel P,Betz S,Kalisch R,Sigurdsson T,Duvarci S
A-11122 was used in Immunohistochemistry to identify a prediction error-like neuronal signal that is necessary to initiate fear extinction and reveal a crucial role of DA neurons in this form of safety learning.
Tue Nov 13 00:00:00 UTC 2018
Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons.
Molecular autism
Xu Q,Liu YY,Wang X,Tan GH,Li HP,Hulbert SW,Li CY,Hu CC,Xiong ZQ,Xu X,Jiang YH
A-11122 was used in Immunohistochemistry-immunofluorescence to study the mechanism by which CHD8 deficiency causes autism spectrum disorder.
Mon Jan 28 00:00:00 UTC 2019
Glucose promotes cell growth by suppressing branched-chain amino acid degradation.
Nature communications
Shao D,Villet O,Zhang Z,Choi SW,Yan J,Ritterhoff J,Gu H,Djukovic D,Christodoulou D,Kolwicz SC,Raftery D,Tian R
A-11122 was used in Western Blotting to show regulation of KLF15 transcription by glucose is critical for the glucose-BCAA circuit which controls a cascade of obligatory metabolic responses previously unrecognized for cell growth.
Thu Jul 26 00:00:00 UTC 2018
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement.
eLife
Corre J,van Zessen R,Loureiro M,Patriarchi T,Tian L,Pascoli V,Lüscher C
A-11122 was used in Immunohistochemistry to support a model of disinhibition of a subset of VTA DA neurons in opioid reinforcement.
Tue Oct 30 00:00:00 UTC 2018
Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.
Cell
Sun LO,Mulinyawe SB,Collins HY,Ibrahim A,Li Q,Simon DJ,Tessier-Lavigne M,Barres BA
A-11122 was used in Immunohistochemistry to identify key molecular mechanisms governing the regional and temporal specificity of CNS myelination.
Thu Dec 13 00:00:00 UTC 2018
Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace.
Cell reports
Berry JA,Phan A,Davis RL
A-11122 was used in Immunohistochemistry to show a single DAn can drive both learning and forgetting by bidirectionally modulating a cellular memory trace.
Tue Oct 16 00:00:00 UTC 2018
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice.
Nature communications
Kroeger D,Absi G,Gagliardi C,Bandaru SS,Madara JC,Ferrari LL,Arrigoni E,Münzberg H,Scammell TE,Saper CB,Vetrivelan R
A-11122 was used in Immunohistochemistry to find that photostimulation of ventrolateral preoptic nucleusGAL neurons in mice promotes sleep with low frequency stimulation (1-4 Hz), but causes conduction block and waking at frequencies above 8 Hz.
Mon Oct 08 00:00:00 UTC 2018
Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo.
Nature communications
Kotini M,Barriga EH,Leslie J,Gentzel M,Rauschenberger V,Schambony A,Mayor R
A-11122 was used in Western Blotting to demonstrate that in addition to the canonical role described, Connexins act as transcriptional regulators.
Fri Sep 21 00:00:00 UTC 2018
Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs.
Developmental cell
Wang J,Yin Y,Lau S,Sankaran J,Rothenberg E,Wohland T,Meier-Schellersheim M,Knaut H
A-11122 was used in Immunohistochemistry to increase its signaling range.
Mon Sep 24 00:00:00 UTC 2018
The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity.
Life science alliance
Lazzaretti D,Bandholz-Cajamarca L,Emmerich C,Schaaf K,Basquin C,Irion U,Bono F
A-11122 was used in Western Blotting to reveal that Staufen can read sequence features in the minor groove of dsRNA and suggests that these influence target selection in vivo.
Mon Oct 01 00:00:00 UTC 2018
Exocyst dynamics during vesicle tethering and fusion.
Nature communications
Ahmed SM,Nishida-Fukuda H,Li Y,McDonald WH,Gradinaru CC,Macara IG
A-11122 was used in Western Blotting to reveal the mammalian exocyst as a remarkably dynamic two-part complex and provide important insights into assembly/disassembly mechanisms.
Mon Dec 03 00:00:00 UTC 2018
p27Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
Cell reports
Morelli G,Even A,Gladwyn-Ng I,Le Bail R,Shilian M,Godin JD,Peyre E,Hassan BA,Besson A,Rigo JM,Weil M,Brône B,Nguyen L
A-11122 was used in Western Blotting to study the role of p27Kip1 in the modulation of axonal transport.
Tue May 22 00:00:00 UTC 2018
Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.
Cell reports
Ueno M,Nakamura Y,Li J,Gu Z,Niehaus J,Maezawa M,Crone SA,Goulding M,Baccei ML,Yoshida Y
A-11122 was used in Immunohistochemistry to reveal that CS neurons in the motor and sensory cortices differentially control skilled movements through distinct CS-spinal interneuron circuits.
Tue May 01 00:00:00 UTC 2018
Conserved and divergent development of brainstem vestibular and auditory nuclei.
eLife
Lipovsek M,Wingate RJ
A-11122 was used in Immunohistochemistry to find that the developmental origin of the chick auditory interaural time difference circuit supports its emergence from an ancient vestibular network, unrelated to the analogous mammalian counterpart.
Wed Dec 19 00:00:00 UTC 2018
Monitoring brain activity and behaviour in freely moving Drosophila larvae using bioluminescence.
Scientific reports
Marescotti M,Lagogiannis K,Webb B,Davies RW,Armstrong JD
A-11122 was used in Immunohistochemistry to study the neural basis of behavior in Drosophila larvae by use of bioluminescence.
Mon Jun 18 00:00:00 UTC 2018
Light Control of the Tet Gene Expression System in Mammalian Cells.
Cell reports
Yamada M,Suzuki Y,Nagasaki SC,Okuno H,Imayoshi I
A-11122 was used in Immunohistochemistry to demonstrate the optogenetic regulation of exogenous gene expression in vivo, such as in developing and adult mouse brains.
Tue Oct 09 00:00:00 UTC 2018
A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Cell reports
Bai L,Lee Y,Hsu CT,Williams JA,Cavanaugh D,Zheng X,Stein C,Haynes P,Wang H,Gutmann DH,Sehgal A
A-11122 was used in Immunohistochemistry to show that neurofibromin affects the levels and cycling of calcium in multiple circadian peptidergic neurons.
Tue Mar 27 00:00:00 UTC 2018
Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.
Cellular and molecular gastroenterology and hepatology
Smith NR,Swain JR,Davies PS,Gallagher AC,Parappilly MS,Beach CZ,Streeter PR,Williamson IA,Magness ST,Wong MH
A-11122 was used in Immunocytochemistry and Immunohistochemistry to highlight the impact of temporal and physiological context on unappreciated interactions between Lgr5GFP and Bmi1GFP cells during crypt formation.
Sat Jun 03 00:00:00 UTC 2023
Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.
Cellular and molecular gastroenterology and hepatology
Smith NR,Swain JR,Davies PS,Gallagher AC,Parappilly MS,Beach CZ,Streeter PR,Williamson IA,Magness ST,Wong MH
A-11122 was used in Immunocytochemistry and Immunohistochemistry to highlight the impact of temporal and physiological context on unappreciated interactions between Lgr5GFP and Bmi1GFP cells during crypt formation.
Sat Jun 03 00:00:00 UTC 2023
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
eLife
Menzies SA,Volkmar N,van den Boomen DJ,Timms RT,Dickson AS,Nathan JA,Lehner PJ
A-11122 was used in Western Blotting to reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation.
Thu Dec 13 00:00:00 UTC 2018
Sumoylation of RORγt regulates TH17 differentiation and thymocyte development.
Nature communications
He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z
A-11122 was used in Western Blotting to study the mechanism underlying the regulation of RORyt function.
Mon Nov 19 00:00:00 UTC 2018
Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.
Nature communications
Saumweber T,Rohwedder A,Schleyer M,Eichler K,Chen YC,Aso Y,Cardona A,Eschbach C,Kobler O,Voigt A,Durairaja A,Mancini N,Zlatic M,Truman JW,Thum AS,Gerber B
A-11122 was used in Immunohistochemistry to provide a cellular-resolution study case of how brains organize behavior.
Fri Mar 16 00:00:00 UTC 2018
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.
Nature medicine
Oller J,Méndez-Barbero N,Ruiz EJ,Villahoz S,Renard M,Canelas LI,Briones AM,Alberca R,Lozano-Vidal N,Hurlé MA,Milewicz D,Evangelista A,Salaices M,Nistal JF,Jiménez-Borreguero LJ,De Backer J,Campanero MR,Redondo JM
A-11122 was used in Immunohistochemistry to identify the metalloproteinase ADAMTS1 and inducible nitric oxide synthase as therapeutic targets in individuals with thoracic aortic aneurysms and dissections.
Wed Feb 01 00:00:00 UTC 2017
A retinal code for motion along the gravitational and body axes.
Nature
Sabbah S,Gemmer JA,Bhatia-Lin A,Manoff G,Castro G,Siegel JK,Jeffery N,Berson DM
A-11122 was used in Immunohistochemistry to show that for each subtype of DSGC, direction preference varies topographically so as to align with specific translatory optic flow fields, creating a neural ensemble tuned for a specific direction of motion through space.
Thu Jun 22 00:00:00 UTC 2017
Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.
Nature
Dominici C,Moreno-Bravo JA,Puiggros SR,Rappeneau Q,Rama N,Vieugue P,Bernet A,Mehlen P,Chédotal A
A-11122 was used in Immunohistochemistry to show that the classical view that attraction of commissural axons is mediated by a gradient of floor-plate-derived netrin-1 is inaccurate and that netrin-1 primarily acts locally by promoting growth cone adhesion.
Thu May 18 00:00:00 UTC 2017
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.
Nature
Nonomura K,Woo SH,Chang RB,Gillich A,Qiu Z,Francisco AG,Ranade SS,Liberles SD,Patapoutian A
A11122 was used in immunohistochemistry - frozen section to report that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory distress and death in newborn mice
Thu Jan 12 00:00:00 UTC 2017
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Cell
Abraira VE,Kuehn ED,Chirila AM,Springel MW,Toliver AA,Zimmerman AL,Orefice LL,Boyle KA,Bai L,Song BJ,Bashista KA,O'Neill TG,Zhuo J,Tsan C,Hoynoski J,Rutlin M,Kus L,Niederkofler V,Watanabe M,Dymecki SM,Nelson SB,Heintz N,Hughes DI,Ginty DD
A-11122 was used in Immunohistochemistry to study the unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties.
Thu Jan 12 00:00:00 UTC 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
A-11122 was used in Immunohistochemistry to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 UTC 2017
Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior.
Nature neuroscience
Hu C,Petersen M,Hoyer N,Spitzweck B,Tenedini F,Wang D,Gruschka A,Burchardt LS,Szpotowicz E,Schweizer M,Guntur AR,Yang CH,Soba P
A-11122 was used in Immunohistochemistry to show how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behaviour.
Tue Aug 01 00:00:00 UTC 2017
Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin+ progenitors.
Nature neuroscience
Wojcinski A,Lawton AK,Bayin NS,Lao Z,Stephen DN,Joyner AL
A-11122 was used in Immunohistochemistry to study the mechanisms underlying robustness and circuit formation in the cerebellum and the role of other brain regions in developmental regeneration.
Sun Oct 01 00:00:00 UTC 2017
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
The Journal of clinical investigation
Nugent AA,Park JG,Wei Y,Tenney AP,Gilette NM,DeLisle MM,Chan WM,Cheng L,Engle EC
A-11122 was used in Immunohistochemistry to reveal a role for ephrin bidirectional signaling upstream of mutant α2-chimaerin in DRS, which may contribute to the selective vulnerability of abducens motor neurons in this disorder.reveal a role for ephrin bidirectional signaling upstream of mutant α2-chimaerin in DRS, which may contribute to the selective vulnerability of abducens motor neurons in this disorder.
Mon May 01 00:00:00 UTC 2017
Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.
Molecular cell
Ait Saada A,Teixeira-Silva A,Iraqui I,Costes A,Hardy J,Paoletti G,Fréon K,Lambert SAE
A-11122 was used in ChIP assay to show large gaps of ssDNA occuring behind terminally arrested replication forks lead to mitotic sister chromatid bridging in the absence of recombination proteins.
Thu May 04 00:00:00 UTC 2017
A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia.
Neuron
Kaur S,Wang JL,Ferrari L,Thankachan S,Kroeger D,Venner A,Lazarus M,Wellman A,Arrigoni E,Fuller PM,Saper CB
A-11122 was used in Immunohistochemistry-immunofluorescence to study the role of calcitonin gene-related peptide in the CO2 arousal circuit.
Wed Dec 06 00:00:00 UTC 2017
Mechanosensory-Based Phase Coding of Odor Identity in the Olfactory Bulb.
Neuron
Iwata R,Kiyonari H,Imai T
A-11122 was used in Immunohistochemistry to propose that phase, not rate, coding is a robust encoding strategy of odor identity and is ensured by airflow-induced mechanosensation in OSNs.#.
Wed Dec 06 00:00:00 UTC 2017
Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.
Neuron
Papouin T,Dunphy JM,Tolman M,Dineley KT,Haydon PG
A-11122 was used in Immunohistochemistry-immunofluorescence to conclude that astrocytes tune the gating of synaptic NMDARs to the vigilance state and demonstrate that this is directly relevant to schizophrenia, a disorder characterized by NMDAR and cholinergic hypofunctions.
Wed May 17 00:00:00 UTC 2017
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Neuron
Chai H,Diaz-Castro B,Shigetomi E,Monte E,Octeau JC,Yu X,Cohn W,Rajendran PS,Vondriska TM,Whitelegge JP,Coppola G,Khakh BS
A-11122 was used in Immunohistochemistry to combine multiple approaches to identify differing characteristics and functions of triatal and hippocampal astrocytes.
Wed Aug 02 00:00:00 UTC 2017
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Neuron
Chai H,Diaz-Castro B,Shigetomi E,Monte E,Octeau JC,Yu X,Cohn W,Rajendran PS,Vondriska TM,Whitelegge JP,Coppola G,Khakh BS
A-11122 was used in Immunohistochemistry to combine multiple approaches to identify differing characteristics and functions of triatal and hippocampal astrocytes.
Wed Aug 02 00:00:00 UTC 2017
Optogenetic Control of Synaptic Composition and Function.
Neuron
Sinnen BL,Bowen AB,Forte JS,Hiester BG,Crosby KC,Gibson ES,Dell'Acqua ML,Kennedy MJ
A-11122 was used in Immunocytochemistry-immunoflourescence to study the relationship between the number of AMPA-type glutamate receptors in the postsynaptic density and synaptic strength.
Wed Feb 08 00:00:00 UTC 2017
The Emergence of Directional Selectivity in the Visual Motion Pathway of Drosophila.
Neuron
Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MB
A-11122 was used in Immunohistochemistry to study the emergence of directional selectivity in the visual motion detection pathway in Drosophila.
Wed Apr 05 00:00:00 UTC 2017
A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins.
Neuron
François A,Low SA,Sypek EI,Christensen AJ,Sotoudeh C,Beier KT,Ramakrishnan C,Ritola KD,Sharif-Naeini R,Deisseroth K,Delp SL,Malenka RC,Luo L,Hantman AW,Scherrer G
A-11122 was used in Immunohistochemistry to uncover a descending disynaptic inhibitory circuit that facilitates mechanical pain, is engaged during stress, and could be targeted to establish higher pain thresholds.
Wed Feb 22 00:00:00 UTC 2017
Transsynaptic Mapping of Second-Order Taste Neurons in Flies by trans-Tango.
Neuron
Talay M,Richman EB,Snell NJ,Hartmann GG,Fisher JD,Sorkaç A,Santoyo JF,Chou-Freed C,Nair N,Johnson M,Szymanski JR,Barnea G
A-11122 was used in Immunohistochemistry to establish trans-Tango as an effective method for transsynaptic circuit analysis in the Drosophila olfactory system.
Wed Nov 15 00:00:00 UTC 2017
Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.
Nature protocols
Lalit PA,Rodriguez AM,Downs KM,Kamp TJ
A11122 was used in immunocytochemistry to develop a protocol to generate expandable and multipotent induced cardiac progenitor cells from mouse adult fibroblasts
Mon May 01 00:00:00 UTC 2017
Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation.
Developmental cell
Meng J,Ma X,Tao H,Jin X,Witvliet D,Mitchell J,Zhu M,Dong MQ,Zhen M,Jin Y,Qi YB
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal a molecular mechanism underlying synaptic rewiring and developmental circuit plasticity.
Mon Apr 24 00:00:00 UTC 2017
Resolving Heart Regeneration by Replacement Histone Profiling.
Developmental cell
Goldman JA,Kuzu G,Lee N,Karasik J,Gemberling M,Foglia MJ,Karra R,Dickson AL,Sun F,Tolstorukov MY,Poss KD
A-11122 was used in Immunohistochemistry to identify an emerging program of putative enhancers that revise H3.3 occupancy during regeneration, overlaid upon a genome-wide reduction of H3.3 from promoters.
Mon Feb 27 00:00:00 UTC 2017
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
Autophagy
Sasaki T,Lian S,Khan A,Llop JR,Samuelson AV,Chen W,Klionsky DJ,Kishi S
A-11122 was used in Western Blotting to study the molecular mechanism by which loss of Spin/Spns1 leads to specific pathogenesis.
Wed Feb 01 00:00:00 UTC 2017
Multistep regulation of TFEB by MTORC1.
Autophagy
Vega-Rubin-de-Celis S,Peña-Llopis S,Konda M,Brugarolas J
A-11122 was used in Western Blotting to report a novel mechanism of TFEB regulation by MTORC1 essential for lysosome biogenesis.
Sat Mar 04 00:00:00 UTC 2017
ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.
Genes & development
Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN
A-11122 was used in Flow cytometry/Cell sorting to conclude that ZNF281is a nexus of cardiac and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogramming.
Fri Sep 01 00:00:00 UTC 2017
Protein diversity in discrete structures at the distal tip of the trypanosome flagellum.
Proceedings of the National Academy of Sciences of the United States of America
Varga V,Moreira-Leite F,Portman N,Gull K
A-11122 was used in Immunomicroscopy to undergo studies of the trypanosome flagellum in terms of composition, dynamics and function.
Tue Aug 08 00:00:00 UTC 2017
Large-scale heterochromatin remodeling linked to overreplication-associated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Feng W,Hale CJ,Over RS,Cokus SJ,Jacobsen SE,Michaels SD
A-11122 was used in Immunocytochemistry-immunoflourescence to show DNA damage induced by overreplication is linked to heterochromatin remodeling.
Tue Jan 10 00:00:00 UTC 2017
Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.
Proceedings of the National Academy of Sciences of the United States of America
Ho ATV,Palla AR,Blake MR,Yucel ND,Wang YX,Magnusson KEG,Holbrook CA,Kraft PE,Delp SL,Blau HM
A-11122 was used in Immunohistochemistry to reveal that loss of PGE2 signaling to MuSCs during recovery from injury impedes muscle repair and strength.
Tue Jun 27 00:00:00 UTC 2017
The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development.
The Plant cell
Zhu Y,Rong L,Luo Q,Wang B,Zhou N,Yang Y,Zhang C,Feng H,Zheng L,Shen WH,Ma J,Dong A
A-11122 was used in Western Blotting to study the molecular mechanisms by which histone chaperones are recruited to target chromatin.
Wed Feb 01 00:00:00 UTC 2017
The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development.
The Plant cell
Zhu Y,Rong L,Luo Q,Wang B,Zhou N,Yang Y,Zhang C,Feng H,Zheng L,Shen WH,Ma J,Dong A
A-11122 was used in Western Blotting to study the molecular mechanisms by which histone chaperones are recruited to target chromatin.
Wed Feb 01 00:00:00 UTC 2017
Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors.
Current biology : CB
Ren Q,Yang CP,Liu Z,Sugino K,Mok K,He Y,Ito M,Nern A,Otsuna H,Lee T
A-11122 was used in immunofluorescence and immunohistochemistry.
Mon May 08 00:00:00 UTC 2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
Current biology : CB
King AN,Barber AF,Smith AE,Dreyer AP,Sitaraman D,Nitabach MN,Cavanaugh DJ,Sehgal A
A-11122 was used in Immunohistochemistry to define a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of locomotor activity.
Mon Jul 10 00:00:00 UTC 2017
Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance.
Current biology : CB
Tiwari B,Kurtz P,Jones AE,Wylie A,Amatruda JF,Boggupalli DP,Gonsalvez GB,Abrams JM
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that germ plasm targeting represents a fitness strategy adopted by some retrotransposons to ensure transgenerational propagation.
Mon Oct 09 00:00:00 UTC 2017
Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain.
Current biology : CB
Frank DD,Enjin A,Jouandet GC,Zaharieva EE,Para A,Stensmyr MC,Gallio M
A-11122 was used in Immunohistochemistry-immunofluorescence to report the identification of the humid-responding neuron that completes the hygrosensory triad in the Drosophila antenna.
Mon Aug 07 00:00:00 UTC 2017
Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis.
Cellular and molecular gastroenterology and hepatology
Smith NR,Davies PS,Levin TG,Gallagher AC,Keene DR,Sengupta SK,Wieghard N,El Rassi E,Wong MH
A-11122 was used in Immunohistochemistry to support a function for CD166 as an important cell adhesion molecule that shapes the signaling microenvironment by mediating ISC-niche cell interactions.
Mon May 01 00:00:00 UTC 2017
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
The Journal of cell biology
Yasuda K,Clatterbuck-Soper SF,Jackrel ME,Shorter J,Mili S
A-11122 was used in Western Blotting to study the pathogenesis of ALS and reveal novel kinesin-dependent mechanism controlling the MT cytoskeleton and identify loss of Glu-MTs and RNA mislocalization as common outcomes of pathogenic mutations.
Mon Apr 03 00:00:00 UTC 2017
A Magnesium Transporter OsMGT1 Plays a Critical Role in Salt Tolerance in Rice.
Plant physiology
Chen ZC,Yamaji N,Horie T,Che J,Li J,An G,Ma JF
A-11122 was used in Immunohistochemistry to show salt tolerance in rice is facilitated by magnesium transporter OsMGT1 which enhances the transport activity of OsHKT1;5 to restrict sodium accumulation.
Sat Jul 01 00:00:00 UTC 2017
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.
Pain
Samineni VK,Yoon J,Crawford KE,Jeong YR,McKenzie KC,Shin G,Xie Z,Sundaram SS,Li Y,Yang MY,Kim J,Wu D,Xue Y,Feng X,Huang Y,Mickle AD,Banks A,Ha JS,Golden JP,Rogers JA,Gereau RW
A-11122 was used in Immunohistochemistry to present a wireless and battery-free optoelectronic system specific for minimally invasive implantation over the mouse spinal cord for the study of of spinal circuits.
Wed Nov 01 00:00:00 UTC 2017
The cell wall-localized atypical β-1,3 glucanase ZERZAUST controls tissue morphogenesis in Arabidopsis thaliana.
Development (Cambridge, England)
Vaddepalli P,Fulton L,Wieland J,Wassmer K,Schaeffer M,Ranf S,Schneitz K
A-11122 was used in Western Blotting to reveal that the atypical Β-1,3 glucanase ZERZAUST acts in a non-cell-autonomous manner and is required for cell wall organization during tissue morphogenesis.
Thu Jun 15 00:00:00 UTC 2017
Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl.
Development (Cambridge, England)
Yao L,Wang S,Westholm JO,Dai Q,Matsuda R,Hosono C,Bray S,Lai EC,Samakovlis C
A-11122 was used in Immunocytochemistry-immunoflourescence to show that Grh and Vvl participate in a regulatory network controlling epithelial maturation.
Fri Sep 01 00:00:00 UTC 2017
Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field.
Development (Cambridge, England)
Paffett-Lugassy N,Novikov N,Jeffrey S,Abrial M,Guner-Ataman B,Sakthivel S,Burns CE,Burns CG
A-11122 was used in Immunohistochemistry to highlight novel aspects of the second heart field (SHF), primitive outflow tract (OFT) and head muscle (HM) development in zebrafish that will inform mechanistic interpretations of cardiopharyngeal phenotypes in zebrafish models of human congenital disorders.
Fri Dec 15 00:00:00 UTC 2017
Growth control in the Drosophila eye disc by the cytokine Unpaired.
Development (Cambridge, England)
Vollmer J,Fried P,Aguilar-Hidalgo D,Sánchez-Aragón M,Iannini A,Casares F,Iber D
A-11122 was used in Immunohistochemistry-immunofluorescence to study the mechanism of growth control in the Drosophila eye disc by Unpaired.
Wed Mar 01 00:00:00 UTC 2017
Identified Serotonergic Modulatory Neurons Have Heterogeneous Synaptic Connectivity within the Olfactory System of Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Coates KE,Majot AT,Zhang X,Michael CT,Spitzer SL,Gaudry Q,Dacks AM
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that individual modulatory neurons can integrate neuron class-specific input from their target network and provide new insight into the synaptic relationships that underlie network function of modulatory neurons.
Wed Aug 02 00:00:00 UTC 2017
Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pan PY,Li X,Wang J,Powell J,Wang Q,Zhang Y,Chen Z,Wicinski B,Hof P,Ryan TA,Yue Z
A-11122 was used in Immunocytochemistry to study the mechanism of nigral vulnerability by LRRK2 in Parkinson's disease.
Wed Nov 22 00:00:00 UTC 2017
Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pan PY,Li X,Wang J,Powell J,Wang Q,Zhang Y,Chen Z,Wicinski B,Hof P,Ryan TA,Yue Z
A-11122 was used in Immunocytochemistry to study the mechanism of nigral vulnerability by LRRK2 in Parkinson's disease.
Wed Nov 22 00:00:00 UTC 2017
KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apara A,Galvao J,Wang Y,Blackmore M,Trillo A,Iwao K,Brown DP,Fernandes KA,Huang A,Nguyen T,Ashouri M,Zhang X,Shaw PX,Kunzevitzky NJ,Moore DL,Libby RT,Goldberg JL
A-11122 was used in Western Blotting to establish potential therapeutic approaches to promote axon regeneration in injury and other degenerative diseases in adult central nervous system.
Wed Oct 04 00:00:00 UTC 2017
Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yoo JH,Zell V,Wu J,Punta C,Ramajayam N,Shen X,Faget L,Lilascharoen V,Lim BK,Hnasko TS
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate that the pedunculopontine tegmental nucleus sends glutamatergic projections to VTA dopamine neurons, and that stimulation of this circuit promotes behavioral reinforcement.
Wed Jan 04 00:00:00 UTC 2017
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Toriyama M,Toriyama M,Wallingford JB,Finnell RH
A-11122 was used in Immunohistochemistry-immunofluorescence to propose that folic acid promotes normal NTC in some embryos by regulating the methylation of septin2, which is critical for normal cilium formation during early embryonic development.
Tue Aug 01 00:00:00 UTC 2017
Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.
The American journal of pathology
Yamamoto M,Xin B,Watanabe K,Ooshio T,Fujii K,Chen X,Okada Y,Abe H,Taguchi Y,Miyokawa N,Furukawa H,Nishikawa Y
A-11122 was used in Immunohistochemistry to suggest that hepatocyte-derived tumors demonstrate a wide spectrum of tumor phenotypes, including hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and hepatoblastoma-like, through the combinatory effects of the oncogenic pathways and that the state of the phosphoinositide 3-kinasee AKT pathway is a key determinant of differentiation.
Fri Dec 01 00:00:00 UTC 2017
Deletion of Rictor in catecholaminergic neurons alters locomotor activity and ingestive behavior.
Neuropharmacology
Kaska S,Brunk R,Bali V,Kechner M,Mazei-Robison MS
A-11122 was used in Immunohistochemistry to determine the role of ventral tegmental area (VTA) mechanistic target of rapamycin 2 signalling in mediating susceptibility to chronic social defeat stress.
Mon May 01 00:00:00 UTC 2017
Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function.
Journal of cell science
De Gregorio C,Delgado R,Ibacache A,Sierralta J,Couve A
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that trafficking defects produced by Atlastin dysfunction in motor neurons result in redistribution of presynaptic components and aberrant mobilization of synaptic vesicles.
Sun Oct 15 00:00:00 UTC 2017
A versatile optical tool for studying synaptic GABAA receptor trafficking.
Journal of cell science
Lorenz-Guertin JM,Wilcox MR,Zhang M,Larsen MB,Pilli J,Schmidt BF,Bruchez MP,Johnson JW,Waggoner AS,Watkins SC,Jacob TC
A-11122 was used in Immunocytochemistry-immunoflourescence to describe an optical tool to study synaptic γ-aminobutyric acid type A receptor dynamics through adaptable fluorescent-tracking capabilities.
Wed Nov 15 00:00:00 UTC 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
A-11122 was used in Proximity Ligation Assay to demonstrate that Sharpin interacts with Arp2/3 and identified the Arp2/3-binding site in Sharpin.
Fri Sep 15 00:00:00 UTC 2017
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Journal of cell science
Khan MH,Salomaa SI,Jacquemet G,Butt U,Miihkinen M,Deguchi T,Kremneva E,Lappalainen P,Humphries MJ,Pouwels J
A-11122 was used in Proximity Ligation Assay to demonstrate that Sharpin interacts with Arp2/3 and identified the Arp2/3-binding site in Sharpin.
Fri Sep 15 00:00:00 UTC 2017
Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration.
Journal of cell science
Takemura M,Nakato H
A-11122 was used in Immunohistochemistry-immunofluorescence to show that a specific modification of heparan sulfate is crucial for regulating Drosophila intestinal stem cell division during normal midgut homeostasis and regeneration.
Sun Jan 15 00:00:00 UTC 2017
A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation.
Journal of cell science
Wei S,Ning G,Li L,Yan Y,Yang S,Cao Y,Wang Q
A-11122 was used in Immunocytochemistry-immunoflourescence to show that zebrafish net1 is expressed specifically in mesendoderm precursors during gastrulation.
Fri Sep 15 00:00:00 UTC 2017
The B-type cyclin CYB-1 maintains the proper position and number of centrosomes during spermatogenesis in Caenorhabditis elegans.
Journal of cell science
Yoon S,Kawasaki I,Shim YH
A-11122 was used in Immunocytochemistry-immunoflourescence to show that CYB-1 functions to maintain proper positioning of centrosomes during spermatogenesis by regulating phosphorylation of SUN-1 which is possibly crucial for the association between SUN-1 and ZYG-12.
Tue Aug 15 00:00:00 UTC 2017
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses.
Journal of cell science
Chiacchiaretta M,Latifi S,Bramini M,Fadda M,Fassio A,Benfenati F,Cesca F
A-11122 was used in Immunocytochemistry to study the spatio-temporal dynamics of extracellular pH at synaptic sites during neuronal hyperexcitability.
Sat Apr 15 00:00:00 UTC 2017
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses.
Journal of cell science
Chiacchiaretta M,Latifi S,Bramini M,Fadda M,Fassio A,Benfenati F,Cesca F
A-11122 was used in Immunocytochemistry to study the spatio-temporal dynamics of extracellular pH at synaptic sites during neuronal hyperexcitability.
Sat Apr 15 00:00:00 UTC 2017
Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.
Neurobiology of aging
Sun M,Zhang H
A-11122 was used in Western Blotting to provide mechanistic insight into a novel role for Par3 and aPKC in regulating the retrograde endosome-toTGN trafficking of BACE1, and shed light on the mechanisms of Alzheimer's disease(AD) pathogenesis.
Fri Dec 01 00:00:00 UTC 2017
Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.
Endocrinology
Myers B,McKlveen JM,Morano R,Ulrich-Lai YM,Solomon MB,Wilson SP,Herman JP
A-11122 was used in Immunohistochemistry to pinpoint a neurochemical mechanism linking mPFC dysfunction with aberrant neuroendocrine responses to chronic stress.
Sun Oct 01 00:00:00 UTC 2017
The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex.
Cerebral cortex (New York, N.Y. : 1991)
Wu PR,Cho KKA,Vogt D,Sohal VS,Rubenstein JLR
A-11122 was used in Immunohistochemistry to report that CXCL12 is expressed postnatally in layer V pyramidal neurons and localizes on their cell bodies in the medial prefrontal cortex (mPFC), while its receptors CXCR4/CXCR7 localize to the axon terminals of parvalbumin (PV) interneurons.
Fri Sep 01 00:00:00 UTC 2017
Subcellular Targeting of VIP Boutons in Mouse Barrel Cortex is Layer-Dependent and not Restricted to Interneurons.
Cerebral cortex (New York, N.Y. : 1991)
Zhou X,Rickmann M,Hafner G,Staiger JF
A-11122 was used in Immunohistochemistry to study the output connectivity of vasoactive intestinal polypeptide interneurons at the subcellular level in barrel cortex of interneuron-specific Cre-driver mice.
Wed Nov 01 00:00:00 UTC 2017
Subcellular Targeting of VIP Boutons in Mouse Barrel Cortex is Layer-Dependent and not Restricted to Interneurons.
Cerebral cortex (New York, N.Y. : 1991)
Zhou X,Rickmann M,Hafner G,Staiger JF
A-11122 was used in Immunohistochemistry to study the output connectivity of vasoactive intestinal polypeptide interneurons at the subcellular level in barrel cortex of interneuron-specific Cre-driver mice.
Wed Nov 01 00:00:00 UTC 2017
Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina.
Human gene therapy
Ramachandran PS,Lee V,Wei Z,Song JY,Casal G,Cronin T,Willett K,Huckfeldt R,Morgan JI,Aleman TS,Maguire AM,Bennett J
A-11122 was used in Immunohistochemistry-immunofluorescence to study differences in adeno-associated virus transduction between mice and primates.
Wed Feb 01 00:00:00 UTC 2017
Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing.
Clinical orthopaedics and related research
Gelberman RH,Linderman SW,Jayaram R,Dikina AD,Sakiyama-Elbert S,Alsberg E,Thomopoulos S,Shen H
A-11122 was used in Immunohistochemistry-immunofluorescence to study the effect of ASCs and rBMP-12 on the macrophage phenotype and tendon healing.
Fri Sep 01 00:00:00 UTC 2017
The Sox2: GFP+/- knock-in mouse model does not faithfully recapitulate Sox2 expression in skin.
Experimental dermatology
Salz L,Driskell RR
A-11122 was used in Immunohistochemistry to investigate whether the knock-in mouse model faithfully expresses GFP when compared to endogenous Sox2 expression.
Wed Nov 01 00:00:00 UTC 2017
Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus.
Journal of biological rhythms
Chew KS,Fernandez DC,Hattar S,Südhof TC,Martinelli DC
A-11122 was used in Immunohistochemistry to identify C1QL3 as contributing to formation and maintenance of glutamatergic synapses in the Suprachiasmatic nucleus.
Thu Jun 01 00:00:00 UTC 2017
Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders.
Molecular biology of the cell
Hebbar S,Khandelwal A,Jayashree R,Hindle SJ,Chiang YN,Yew JY,Sweeney ST,Schwudke D
A-11122 was used in Immunohistochemistry-immunofluorescence to analyse lipid perturbations in spinster mutants.
Fri Dec 15 00:00:00 UTC 2017
Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.
Molecular biology of the cell
Loveless T,Qadota H,Benian GM,Hardin J
A-11122 was used in Immunohistochemistry-wholemount to establishes SORB-1 as a sorbin family protein-one of the late additions to the dense body complex and a conserved regulator of body wall muscle sarcomere organization and organelle positioning.
Fri Dec 01 00:00:00 UTC 2017
The Temporal Contribution of the Gbx2 Lineage to Cerebellar Neurons.
Frontiers in neuroanatomy
Hagan N,Guarente J,Ellisor D,Zervas M
A-11122 was used in Immunocytochemistry to study the role of Gbx2 in positioning and maintaining the isthmus organiser and guiding the development of the cerebellum.
Thu Oct 01 00:00:00 UTC 2020
Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.
Biochemistry
Kim SA,D'Acunto VF,Kokona B,Hofmann J,Cunningham NR,Bistline EM,Garcia FJ,Akhtar NM,Hoffman SH,Doshi SH,Ulrich KM,Jones NM,Bonini NM,Roberts CM,Link CD,Laue TM,Fairman R
A-11122 was used in Western Blotting to emphasizes the value of the analytical ultracentrifuge equipped with fluorescence detection as a useful and rigorous tool for in situ aggregation analysis to assess commonalities in aggregation across animal model systems.
Tue Sep 05 00:00:00 UTC 2017
The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.
The Journal of experimental biology
Almeida-Carvalho MJ,Berh D,Braun A,Chen YC,Eichler K,Eschbach C,Fritsch PMJ,Gerber B,Hoyer N,Jiang X,Kleber J,Klämbt C,König C,Louis M,Michels B,Miroschnikow A,Mirth C,Miura D,Niewalda T,Otto N,Paisios E,Pankratz MJ,Petersen M,Ramsperger N,Randel N,Risse B,Saumweber T,Schlegel P,Schleyer M,Soba P,Sprecher SG,Tanimura T,Thum AS,Toshima N,Truman JW,Yarali A,Zlatic M
A-11122 was used in Immunohistochemistry-immunofluorescence to further contribute in the confidence in mapping brain structure and behaviour across developmental stages in Drosophila larvae.
Sat Jul 01 00:00:00 UTC 2017
Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification.
Neuroscience letters
Gray NE,Zweig JA,Murchison C,Caruso M,Matthews DG,Kawamoto C,Harris CJ,Quinn JF,Soumyanath A
A-11122 was used in Immunocytochemistry-immunoflourescence to suggest that CAW, and several of the compounds found therein, can improve dendritic arborization and synaptic differentiation in the context of AΒ exposure which may underlie the cognitive improvement observed in response to the extract in vivo.
Wed Apr 12 00:00:00 UTC 2017
Splice form-dependent regulation of axonal arbor complexity by FMRP.
Developmental neurobiology
Zimmer SE,Doll SG,Garcia ADR,Akins MR
A-11122 was used in Western Blotting to reveal domain-specific functions of Fragile X mental retardation protein in the regulation of axonal complexity that may be controlled by differential expression of FMRP splice forms.
Thu Jun 01 00:00:00 UTC 2017
Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.
Nature communications
Frangeul L,Kehayas V,Sanchez-Mut JV,Fièvre S,Krishna-K K,Pouchelon G,Telley L,Bellone C,Holtmaat A,Gräff J,Macklis JD,Jabaudon D
A-11122 was used in Immunohistochemistry-immunofluorescence to reveal an input-dependent control over neuronal excitability and dendritic complexity in the development and plasticity of sensory pathways.
Fri Dec 08 00:00:00 UTC 2017
CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior.
Current biology : CB
Malvaut S,Gribaudo S,Hardy D,David LS,Daroles L,Labrecque S,Lebel-Cormier MA,Chaker Z,Coté D,De Koninck P,Holzenberger M,Trembleau A,Caille I,Saghatelyan A
A-11122 was used in Immunohistochemistry to examine whether functionally distinct granule cells subtypes exist in the bulbar network.
Mon Nov 06 00:00:00 UTC 2017
Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells.
Genome medicine
Middelkamp S,van Heesch S,Braat AK,de Ligt J,van Iterson M,Simonis M,van Roosmalen MJ,Kelder MJ,Kruisselbrink E,Hochstenbach R,Verbeek NE,Ippel EF,Adolfs Y,Pasterkamp RJ,Kloosterman WP,Kuijk EW,Cuppen E
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that a combination of patient-derived iPSC differentiation and trio-based molecular profiling is a powerful approach to improve the interpretation of pathogenic complex genomic rearrangements.
Thu Jan 26 00:00:00 UTC 2017
Anatomic and Physiologic Heterogeneity of Subgroup-A Auditory Sensory Neurons in Fruit Flies.
Frontiers in neural circuits
Ishikawa Y,Okamoto N,Nakamura M,Kim H,Kamikouchi A
A-11122 was used in Immunohistochemistry to explored the diversity of subgroup-A neurons (one of five subgroups of mechanosensory neurons in the fly ear, using 11 GAL4 strains that selectively label subgroup-A neurons, by combining single-cell anatomic analysis and Ca2+ imaging.
Wed May 02 00:00:00 UTC 2018
A multiplexable TALE-based binary expression system for in vivo cellular interaction studies.
Nature communications
Toegel M,Azzam G,Lee EY,Knapp DJHF,Tan Y,Fa M,Fulga TA
A-11122 was used in Immunohistochemistry to demonstrate multiplexed orthogonal activation of several transgenes carrying cognate variable activating sequences in distinct neighbouring cell types of the Drosophila central nervous system.
Tue Nov 21 00:00:00 UTC 2017
A role for cerebellum in the hereditary dystonia DYT1.
eLife
Fremont R,Tewari A,Angueyra C,Khodakhah K
A-11122 was used in Immunohistochemistry to determine the role of the cerebellum in DYT1 dysfunction.
Wed Feb 15 00:00:00 UTC 2017
Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons.
Cell reports
Masurkar AV,Srinivas KV,Brann DH,Warren R,Lowes DC,Siegelbaum SA
A-11122 was used in Immunohistochemistry to reveal a heterogeneity in EC-CA1 connectivity that may help explain differential roles of CA1 PNs in spatial and non-spatial learning and memory.
Tue Jan 03 00:00:00 UTC 2017
Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory.
Nature communications
Plaçais PY,de Tredern É,Scheunemann L,Trannoy S,Goguel V,Han KA,Isabel G,Preat T
A-11122 was used in Immunohistochemistry to investigate how energy metabolism in the Drosophila mushroom body regulates long-term memory formation.
Mon Jun 05 00:00:00 UTC 2017
Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
PloS one
Peng C,Engle SE,Yan Y,Weera MM,Berry JN,Arvin MC,Zhao G,McIntosh JM,Chester JA,Drenan RM
A-11122 was used in Immunohistochemistry to reveal that attenuation of α4* nAChR function in reward-related brain circuitry of adult animals may increase nicotine intake by enhancing the rewarding effects and/or reducing the aversive effects of nicotine.
Thu Sep 28 00:00:00 UTC 2017
Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration.
Development (Cambridge, England)
Kaslin J,Kroehne V,Ganz J,Hans S,Brand M
A-11122 was used in Immunohistochemistry to find that neuroepithelial cells are the predominant stem cell type supporting cerebellar regeneration after injury.
Sat Apr 15 00:00:00 UTC 2017
Engraftment of FACS Isolated Muscle Stem Cells into Injured Skeletal Muscle.
Methods in molecular biology (Clifton, N.J.)
Tierney M,Sacco A
A-11122 was used in Immunohistochemistry-immunofluorescence to describe the procedures for Fluorescent Activated Cell Sorting (FACS)-based isolation of MuSC, their intramuscular transplantation, and analysis of their engraftment into host tissues.
Mon Feb 26 00:00:00 UTC 2018
Discrete Serotonin Systems Mediate Memory Enhancement and Escape Latencies after Unpredicted Aversive Experience in Drosophila Place Memory.
Frontiers in systems neuroscience
Sitaraman D,Kramer EF,Kahsai L,Ostrowski D,Zars T
A-11122 was used in Immunohistochemistry to describe discrete serotonin neuronal circuits that mediate aversive reinforcement, escape latencies, and memory levels after place learning in the presence and absence of unexpected aversive events.
Wed Sep 30 00:00:00 UTC 2020
Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking.
Proceedings of the National Academy of Sciences of the United States of America
Sheng N,Shi YS,Nicoll RA
A-11122 was used in Immunohistochemistry to use the CA1 hippocampal pyramidal cell, which lacks KAR-mediated synaptic currents, as a null background to determine the minimal requirements for the extrasynaptic and synaptic expression of the GluK2 subunit.
Tue Jan 31 00:00:00 UTC 2017
Turtle interacts with borderless in regulating glial extension and axon ensheathment.
Molecular brain
Chen Y,Cameron S,Chang WT,Rao Y
A-11122 was used in Immunohistochemistry to propose that Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.
Tue May 23 00:00:00 UTC 2017
Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells.
Stem cell research
Coppiello G,Abizanda G,Aguado N,Iglesias E,Iglesias-Garcia O,Lo Nigro A,Prosper F,Aranguren XL
A-11122 was used in Immunohistochemistry-immunofluorescence to study two rat embryonic stem cell lines.
Mon May 01 00:00:00 UTC 2017
Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.
eLife
Yao S,Bergan J,Lanjuin A,Dulac C
A-11122 was used in Immunohistochemistry to uncover the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
Tue Dec 12 00:00:00 UTC 2017
Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon.
Scientific reports
Liu YH,Tsai JW,Chen JL,Yang WS,Chang PC,Cheng PL,Turner DL,Yanagawa Y,Wang TW,Yu JY
A-11122 was used in Immunohistochemistry to demonstrate that achaete-scute family bHLH transcription factor 1 promotes tangential migration of cortical interneurons during development.
Thu Mar 09 00:00:00 UTC 2017
Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement.
Cell reports
Zhang J,Tu Z,Watanabe Y,Shibuya H
A-11122 was used in Immunocytochemistry to reveal an essential role for TRF1 in directing the assembly of TERB1-TERB2-MAJIN.
Tue Nov 14 00:00:00 UTC 2017
Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis.
International journal of molecular sciences
Toyoda Y,Takada T,Gomi T,Nakagawa H,Ishikawa T,Suzuki H
A11122 was used in western blot to study the effect of a non-synonymous single nucleotide polymorphism in human ATP-binding cassette C11 (G180R)
Wed Feb 15 00:00:00 UTC 2017
Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.
Proceedings of the National Academy of Sciences of the United States of America
de Morrée A,van Velthoven CTJ,Gan Q,Salvi JS,Klein JDD,Akimenko I,Quarta M,Biressi S,Rando TA
A-11122 was used in Immunohistochemistry to show that MuSCs express MyoD mRNA and actively repress its translation to remain quiescent yet primed for activation.
Tue Oct 24 00:00:00 UTC 2017
The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.
Nature communications
Mudholkar K,Fitzke E,Prinz C,Mayer MP,Rospert S
A-11122 was used in Western Blot to show that the ribosome biogenesis defect associated with the loss of Ssb is attributable to a specific disruption in TORC1 signaling rather than defects in ribosomal protein folding.
Mon Oct 16 00:00:00 UTC 2017
Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1.
American journal of physiology. Renal physiology
Bartlett CS,Scott RP,Carota IA,Wnuk ML,Kanwar YS,Miner JH,Quaggin SE
A-11122 was used in Immunohistochemistry (Paraffin) to identify a critical cell-autonomous role for Nrp1 in the migratory behavior of mesangial cells and may help explain the renal effects that occur in patients receiving Nrp1-inhibitory drugs.
Fri Dec 01 00:00:00 UTC 2017
The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Nature communications
Teixeira-Silva A,Ait Saada A,Hardy J,Iraqui I,Nocente MC,Fréon K,Lambert SAE
A-11122 was used in Immunoprecipitation to uncover a role for Ku in regulating end-resection of unbroken forks and in fine-tuning homologous recombination-mediated replication restart.
Thu Dec 07 00:00:00 UTC 2017
The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Nature communications
Teixeira-Silva A,Ait Saada A,Hardy J,Iraqui I,Nocente MC,Fréon K,Lambert SAE
A-11122 was used in Immunoprecipitation to uncover a role for Ku in regulating end-resection of unbroken forks and in fine-tuning homologous recombination-mediated replication restart.
Thu Dec 07 00:00:00 UTC 2017
An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio.
Nature communications
Sadybekov A,Tian C,Arnesano C,Katritch V,Herring BE
A-11122 was used in Immunohistochemistry-immunofluorescence to identify a large cluster of de novo mutations in the GEF1 domain of Trio in whole-exome sequencing data from individuals with ASD, and confirm that some of these mutations lead to glutamatergic dysregulation in vitro.
Tue Sep 19 00:00:00 UTC 2017
Characterizing Semaphorin-Mediated Effects on Sensory and Motor Axon Pathfinding and Connectivity During Embryonic Development.
Methods in molecular biology (Clifton, N.J.)
Huettl RE,Huber AB
A-11122 was used in Immunohistochemistry-immunofluorescence to provide a detailed methodology to characterize class 3 semaphorin-mediated effects on peripheral sensory and motor axon pathfinding and connectivity during embryonic development.
Thu Feb 15 00:00:00 UTC 2018
Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines.
eLife
Bowen AB,Bourke AM,Hiester BG,Hanus C,Kennedy MJ
A-11122 was used in Immunocytochemistry to define the dendritic trafficking itinerary for key synaptic molecules in rat cortical neurons.
Wed Sep 06 00:00:00 UTC 2017
Direct Cardiac Reprogramming as a Novel Therapeutic Strategy for Treatment of Myocardial Infarction.
Methods in molecular biology (Clifton, N.J.)
Ma H,Wang L,Liu J,Qian L
A-11122 was used in Immunocytochemistry to develop a detailed protocol for both in vitro and in vivo induced cardiomyocyte generation.
Mon Jan 15 00:00:00 UTC 2018
Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression.
PLoS genetics
Quigley IK,Kintner C
A-11122 was used in Chromatin immunoprecipitation to investigate if cilia genes reside at the boundaries of topological domains and if these areas have low enhancer density.
Sun Jan 01 00:00:00 UTC 2017
Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.
Scientific reports
Wietek J,Rodriguez-Rozada S,Tutas J,Tenedini F,Grimm C,Oertner TG,Soba P,Hegemann P,Wiegert JS
A-11122 was used in Immunohistochemistry to show how, in Drosophila larvae, eACRs conveyed robust and specific light-dependent inhibition of locomotion and nociception.
Thu Nov 02 00:00:00 UTC 2017
Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca2+ Sensor Protein.
Cell reports
Zhou K,Cherra SJ,Goncharov A,Jin Y
A-11122 was used in Immunohistochemistry-wholemount to reveal a synaptic mechanism that implicates asynchronous release in regulation of excitation-inhibition balance and how this imbalance can be linked to neurological disorders.
Tue May 09 00:00:00 UTC 2017
Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs.
Nature communications
Hsia EYC,Zhang Y,Tran HS,Lim A,Chou YH,Lan G,Beachy PA,Zheng X
A-11122 was used in Immunohistochemistry to determine that interference hedgehog spatial discontinuity may contribute to classically defined cell segregation and lineage restriction at the anterior/posterior wing disc compartment boundary in Drosophila.
Thu Nov 02 00:00:00 UTC 2017
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
Nature communications
Péan CB,Schiebler M,Tan SW,Sharrock JA,Kierdorf K,Brown KP,Maserumule MC,Menezes S,Pilátová M,Bronda K,Guermonprez P,Stramer BM,Andres Floto R,Dionne MS
A11122 was used in immunocytochemistry to test whether cytokine-STAT signaling is one of the molecular mechanisms regulating immunity during mycobaterial infection of macrophages
Mon Mar 06 00:00:00 UTC 2017
Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray.
eNeuro
Samineni VK,Grajales-Reyes JG,Copits BA,O'Brien DE,Trigg SL,Gomez AM,Bruchas MR,Gereau RW
A-11122 was used in Immunohistochemistry to study bidirectional modulation of nociception by excitatory and inhibitory neurons in the periaqueductal grey.
Fri Oct 27 00:00:00 UTC 2017
A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation.
Cell reports
Kiragasi B,Wondolowski J,Li Y,Dickman DK
A-11122 was used in Immunohistochemistry to propose that DKaiR1D is a glutamate autoreceptor that promotes robustness to synaptic strength and plasticity with active zone specificity.
Tue Jun 27 00:00:00 UTC 2017
A versatile genetic tool for post-translational control of gene expression in Drosophila melanogaster.
eLife
Sethi S,Wang JW
A-11122 was used in Immunohistochemistry to demonstrate the applicability of this technology in manipulating neuronal activity and for high-efficiency sparse labeling of neuronal populations.
Wed Nov 15 00:00:00 UTC 2017
Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy.
Frontiers in neuroscience
van Wyk M,Hulliger EC,Girod L,Ebneter A,Kleinlogel S
A-11122 was used in Immunohistochemistry-immunofluorescence to find that (1) the 4xGRM6-SV40 promoter is not OBC specific, (2) that all AAV variants possess broad cellular transduction patterns, with differences between transduction patterns of capsid variants AAVBP2 and AAV7m8 and, most importantly (3) that all vectors target OBCs in healthy tissue but not in degenerated rd1 mouse model, potentially limiting possibilities for OBC-targeted optogenetic therapy for vision restoration in the blind.
Thu Oct 01 00:00:00 UTC 2020
SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana.
PloS one
Soto-Burgos J,Bassham DC
A-11122 was used in Western Blotting to demonstrate that the kinase SnRK1 acts upstream of TOR (target of rapamycin) signalling in the activation of autophagy in Arabidopsis.
Fri Oct 06 00:00:00 UTC 2017
The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3.
Nature communications
Choi ES,Cheon Y,Kang K,Lee D
A-11122 was used in Chromatin immunoprecipitation to provide evidence that the chromatin remodeller Ino80 promotes CENP-A chromatin assembly at the centromere in fission yeast.
Wed Sep 13 00:00:00 UTC 2017
Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
The Journal of biological chemistry
Hara K,Taharazako S,Ikeda M,Fujita H,Mikami Y,Kikuchi S,Hishiki A,Yokoyama H,Ishikawa Y,Kanno SI,Tanaka K,Hashimoto H
A-11122 was used in Western Blotting to show the first structural study of MAD2L2 aside from its role in TLS and might pave the way to clarify MAD2L2's function in mitosis.
Fri Oct 27 00:00:00 UTC 2017
Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
The Journal of biological chemistry
Hara K,Taharazako S,Ikeda M,Fujita H,Mikami Y,Kikuchi S,Hishiki A,Yokoyama H,Ishikawa Y,Kanno SI,Tanaka K,Hashimoto H
A-11122 was used in Western Blotting to show the first structural study of MAD2L2 aside from its role in TLS and might pave the way to clarify MAD2L2's function in mitosis.
Fri Oct 27 00:00:00 UTC 2017
A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex.
eLife
Renier N,Dominici C,Erzurumlu RS,Kratochwil CF,Rijli FM,Gaspar P,Chédotal A
A-11122 was used in Immunohistochemistry to describe Robo3 mouse mutants where a large fraction of the trigemino-thalamic inputs project ipsilaterally rather contralaterally in the primary somatosensory cortex.
Tue Mar 28 00:00:00 UTC 2017
The genomic landscape of pediatric myelodysplastic syndromes.
Nature communications
Schwartz JR,Ma J,Lamprecht T,Walsh M,Wang S,Bryant V,Song G,Wu G,Easton J,Kesserwan C,Nichols KE,Mullighan CG,Ribeiro RC,Klco JM
A-11122 was used in Western Blotting to describe the somatic and germline changes of pediatric Myelodysplastic syndromes (MDS) using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients.
Thu Nov 16 00:00:00 UTC 2017
Molecular and Cellular Organization of Taste Neurons in Adult Drosophila Pharynx.
Cell reports
Chen YD,Dahanukar A
A-11122 was used in Immunohistochemistry to establish an understanding of pharyngeal taste organs in a Drosophila model, in regards to controlling feeding behaviours.
Tue Dec 05 00:00:00 UTC 2017
Chromatin organization changes during the establishment and maintenance of the postmitotic state.
Epigenetics & chromatin
Ma Y,Buttitta L
A-11122 was used in Immunohistochemistry to study the relationship between chromatin organisation, terminal differentiation and cell cycle exit.
Fri Nov 10 00:00:00 UTC 2017
Female-specific myoinhibitory peptide neurons regulate mating receptivity in Drosophila melanogaster.
Nature communications
Jang YH,Chae HS,Kim YJ
A-11122 was used in Immunohistochemistry to show that Mip neuropeptides appear to promote mating receptivity both in virgins and mated females, although it is dispensable for normal mating in virgin females.
Tue Nov 21 00:00:00 UTC 2017
Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila.
Nature communications
Chen D,Sitaraman D,Chen N,Jin X,Han C,Chen J,Sun M,Baker BS,Nitabach MN,Pan Y
A-11122 was used in Immunohistochemistry to study the mechanisms underlying the interaction between sleep and sexual behaviours in Drosophila.
Fri Jul 28 00:00:00 UTC 2017
Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.
Cerebral cortex (New York, N.Y. : 1991)
Krzisch M,Fülling C,Jabinet L,Armida J,Gebara E,Cassé F,Habbas S,Volterra A,Hornung JP,Toni N
A-11122 was used in Western Blotting to test the effect of a cell-autonomous overexpression of synaptic adhesion molecules on the maturation and survival of neurons born postnatally and on hippocampal-dependent memory performances.
Tue Aug 01 00:00:00 UTC 2017
Causal role for the subthalamic nucleus in interrupting behavior.
eLife
Fife KH,Gutierrez-Reed NA,Zell V,Bailly J,Lewis CM,Aron AR,Hnasko TS
A-11122 was used in Immunohistochemistry to determine the role of the subthalamic nucleus in behavioural response suppression.
Tue Jul 25 00:00:00 UTC 2017
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.
Cell reports
Cho GS,Lee DI,Tampakakis E,Murphy S,Andersen P,Uosaki H,Chelko S,Chakir K,Hong I,Seo K,Chen HV,Chen X,Basso C,Houser SR,Tomaselli GF,O'Rourke B,Judge DP,Kass DA,Kwon C
A-11122 was used in Immunohistochemistry to demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts.
Tue Jan 10 00:00:00 UTC 2017
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain.
Scientific reports
Samineni VK,Mickle AD,Yoon J,Grajales-Reyes JG,Pullen MY,Crawford KE,Noh KN,Gereau GB,Vogt SK,Lai HH,Rogers JA,Gereau RW
A-11122 was used in Immunohistochemistry to study the role of noiciceptive sensory afferents in freely behaving mice.
Mon Nov 20 00:00:00 UTC 2017
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nature communications
Yamamura K,Uruno T,Shiraishi A,Tanaka Y,Ushijima M,Nakahara T,Watanabe M,Kido-Nakahara M,Tsuge I,Furue M,Fukui Y
A11122 was used in EMSA to find that CD4+ T cells from DOCK8-deficient mice produce large amounts of IL-31
Mon Jan 09 00:00:00 UTC 2017
Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9.
Scientific reports
Pohar J,Lainšček D,Kunšek A,Cajnko MM,Jerala R,Benčina M
A-11122 was used in Western Blotting to highlight the functional signifcance of the phosphodiester linkage of a CpG dinucleotide for binding, which is important in designing improved immunostimulatory TLR9 agonists.
Mon Nov 06 00:00:00 UTC 2017
Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1.
The Journal of biological chemistry
Wang S,Wang S,Asgar J,Joseph J,Ro JY,Wei F,Campbell JN,Chung MK
A-11122 was used in Immunohistochemistry to study the molecular mechanisms underlying the effects of caspaicin on nociceptors.
Fri May 19 00:00:00 UTC 2017
Second-generation method for analysis of chromatin binding with formaldehyde-cross-linking kinetics.
The Journal of biological chemistry
Zaidi H,Hoffman EA,Shetty SJ,Bekiranov S,Auble DT
A-11122 was used in Chromatin immunoprecipitation to show that this improved method yields more accurate in vivo binding kinetics estimates on the minute time scale.
Fri Nov 24 00:00:00 UTC 2017
A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells.
Cell chemical biology
Schifferer M,Yushchenko DA,Stein F,Bolbat A,Schultz C
A-11122 was used in Western Blotting to develop a method for measuring insulin release from single cells using a genetically encoded reporter termed RINS1 based on proinsulin superfolder GFP and mCherry fusions.
Thu Apr 20 00:00:00 UTC 2017
Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity.
The Journal of biological chemistry
Wu Q,Sun M,Bernard LP,Zhang H
A-11122 was used in Immunoprecipitation to reveal insight into the regulation of PSD-95 in dendritic spine structural plasticity through phosphorylation-mediated regulation of protein dynamics and conformation.
Fri Sep 29 00:00:00 UTC 2017
Alix is required during development for normal growth of the mouse brain.
Scientific reports
Laporte MH,Chatellard C,Vauchez V,Hemming FJ,Deloulme JC,Vossier F,Blot B,Fraboulet S,Sadoul R
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate, using a mouse model, the essential role of Alix in determining brain size during development.
Tue Mar 21 00:00:00 UTC 2017
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2.
Nature
Liu Z,Li X,Zhang JT,Cai YJ,Cheng TL,Cheng C,Wang Y,Zhang CC,Nie YH,Chen ZF,Bian WJ,Zhang L,Xiao J,Lu B,Zhang YF,Zhang XD,Sang X,Wu JJ,Xu X,Xiong ZQ,Zhang F,Yu X,Gong N,Zhou WH,Sun Q,Qiu Z
A-11122 was used in western blot to discuss using genetically engineered non-human primates to study brain disorders
Thu Feb 04 00:00:00 UTC 2016
Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice.
Nature
Wells MF,Wimmer RD,Schmitt LI,Feng G,Halassa MM
A-11122 was used in immunohistochemistry to investigate how PTCHD1 contributes to behavioral defects
Thu Apr 07 00:00:00 UTC 2016
Motor neurons control locomotor circuit function retrogradely via gap junctions.
Nature
Song J,Ampatzis K,Björnfors ER,El Manira A
A-11122 was used in immunohistochemistry to report a role for motor neurons in controlling the locomotor circuit function via gap junctions in zebrafish
Thu Jan 21 00:00:00 UTC 2016
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Nature
Mei Y,Monteiro P,Zhou Y,Kim JA,Gao X,Fu Z,Feng G
A-11122 was used in immunohistochemistry to examine the developmental requirement of Shank3.
Thu Feb 25 00:00:00 UTC 2016
A specific area of olfactory cortex involved in stress hormone responses to predator odours.
Nature
Kondoh K,Lu Z,Ye X,Olson DP,Lowell BB,Buck LB
A-11122 was used in immunohistochemistry - frozen section to study the stress hormone responses to predator odours in a specific area of the olfactory cortex
Thu Apr 07 00:00:00 UTC 2016
Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
Nature neuroscience
Ueno M,Ueno-Nakamura Y,Niehaus J,Popovich PG,Yoshida Y
A-11122 was used in Immunohistochemistry to provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
Wed Jun 01 00:00:00 UTC 2016
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.
The Journal of clinical investigation
Martin-Almedina S,Martinez-Corral I,Holdhus R,Vicente A,Fotiou E,Lin S,Petersen K,Simpson MA,Hoischen A,Gilissen C,Jeffery H,Atton G,Karapouliou C,Brice G,Gordon K,Wiseman JW,Wedin M,Rockson SG,Jeffery S,Mortimer PS,Snyder MP,Berland S,Mansour S,Makinen T,Ostergaard P
A-11122 was used in immunohistochemistry identify EPHB4 as a critical regulator of early lymphatic vascular development and show that mutation of this gene are associated with lymphatic-related (nonimmune) hydrops fetalis
Mon Aug 01 00:00:00 UTC 2016
Dopaminergic Circuitry Underlying Mating Drive.
Neuron
Zhang SX,Rogulja D,Crickmore MA
A-11122 was used in Immunohistochemistry-immunofluorescence to demonstrate the existence of male mating drive in Drosophila, which is transiently and cumulatively reduced as reproductive capacity is depleted by copulations.
Wed Jul 06 00:00:00 UTC 2016
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.
Nature structural & molecular biology
De Franceschi N,Arjonen A,Elkhatib N,Denessiouk K,Wrobel AG,Wilson TA,Pouwels J,Montagnac G,Owen DJ,Ivaska J
A-11122 was used in immunoprecipitation and western blot to monitor the interaction beteween integrin alpha chain and AP2 and how selective integrin endocytosis drives the interaction
Mon Feb 01 00:00:00 UTC 2016
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.
The Journal of experimental medicine
Patzke C,Acuna C,Giam LR,Wernig M,Südhof TC
A-11122 was used in immunocytochemistry to elucidate the mechanisms by which L1CAM gene mutations result in neuronal defects
Mon Apr 04 00:00:00 UTC 2016
Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation.
Journal of the American Society of Nephrology : JASN
Sharmin S,Taguchi A,Kaku Y,Yoshimura Y,Ohmori T,Sakuma T,Mukoyama M,Yamamoto T,Kurihara H,Nishinakamura R
A-11122 was used in immunohistochemistry - paraffin section to generate and characterize podocytes derived from iPS cells
Wed Jun 01 00:00:00 UTC 2016
Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells.
Developmental cell
Rux DR,Song JY,Swinehart IT,Pineault KM,Schlientz AJ,Trulik KG,Goldstein SA,Kozloff KM,Lucas D,Wellik DM
A11122 was used in immunohistochemistry - frozen section to investigate Hox expression and function in skeletal mesenchymal stromal cells
Mon Dec 19 00:00:00 UTC 2016
Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries.
Molecular therapy : the journal of the American Society of Gene Therapy
Körbelin J,Sieber T,Michelfelder S,Lunding L,Spies E,Hunger A,Alawi M,Rapti K,Indenbirken D,Müller OJ,Pasqualini R,Arap W,Kleinschmidt JA,Trepel M
A-11122 was used in immunohistochemistry - paraffin section to utilize next-generation sequencing-guided screening of random capsid displayed peptide libraries to identify pulmonary targeting of adeno-associated viral vectors
Wed Jun 01 00:00:00 UTC 2016
Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.
Proceedings of the National Academy of Sciences of the United States of America
Shlevkov E,Kramer T,Schapansky J,LaVoie MJ,Schwarz TL
A-11122 was used in Western Blot to propose that the status of Miro phosphorylation influences the decision to undergo Parkin-dependent mitochondrial arrest, which, in the context of PINK1 action on other substrates, can restrict mitochondrial dynamics before mitophagy.
Tue Oct 11 00:00:00 UTC 2016
Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.
Proceedings of the National Academy of Sciences of the United States of America
Herring BE,Nicoll RA
A-11122 was used in immunocytochemistry elucidate how CaMKII gives rise to long-term potentiation
Tue Feb 23 00:00:00 UTC 2016
Sex-specific regulation of Lgr3 in Drosophila neurons.
Proceedings of the National Academy of Sciences of the United States of America
Meissner GW,Luo SD,Dias BG,Texada MJ,Baker BS
A-11122 was used in immunohistochemistry to analyze sex-specific regulation of Lgr3 in Drosophila neurons
Tue Mar 01 00:00:00 UTC 2016
Tousled-like kinase mediated a new type of cell death pathway in Drosophila.
Cell death and differentiation
Zhang Y,Cai R,Zhou R,Li Y,Liu L
A-11122 was used in immunohistochemistry to study how ectopic expression of tousled-like kinase in Drosophila results in a new type of cell death independent of known death pathways
Fri Jan 01 00:00:00 UTC 2016
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Cell systems
Joost S,Zeisel A,Jacob T,Sun X,La Manno G,Lönnerberg P,Linnarsson S,Kasper M
A-11122 was used in Immunohistochemistry on paraffin embedded tissues to investigate how cellular heterogeneity of murine telogen epidermis is tuned at the transcriptional level, showing that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity.
Wed Sep 28 00:00:00 UTC 2016
Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.
Current biology : CB
McPherson AD,Barrios JP,Luks-Morgan SJ,Manfredi JP,Bonkowsky JL,Douglass AD,Dorsky RI
A-11122 was used in Immunohistochemistry to identify a progenitor population in the zebrafish hypothalamus that continuously generates neurons that express tyrosine hydroxylase.
Mon Jan 25 00:00:00 UTC 2016
Cell Class-Lineage Analysis Reveals Sexually Dimorphic Lineage Compositions in the Drosophila Brain.
Current biology : CB
Ren Q,Awasaki T,Huang YF,Liu Z,Lee T
A-11122 was used in Immunohistochemistry to develop the transgenic cell class-lineage intersection system to assign cells of a particular class to specific lineages within the Drosophila brain.
Mon Oct 10 00:00:00 UTC 2016
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Arteriosclerosis, thrombosis, and vascular biology
Schossleitner K,Rauscher S,Gröger M,Friedl HP,Finsterwalder R,Habertheuer A,Sibilia M,Brostjan C,Födinger D,Citi S,Petzelbauer P
A-11122 was used in Western Blotting to investigate the role of cingulin in the barrier function of endothelial cells.
Fri Apr 01 00:00:00 UTC 2016
Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
Journal of integrative plant biology
Li Z,Li B,Liu J,Guo Z,Liu Y,Li Y,Shen WH,Huang Y,Huang H,Zhang Y,Dong A
A-11122 was used in ChIP assay and western blot to study the interaction of LHP1 to repress KNOX genes in arabidopsis with transcription factors AS1 and AS2
Thu Dec 01 00:00:00 UTC 2016
Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.
Development (Cambridge, England)
Yang CP,Fu CC,Sugino K,Liu Z,Ren Q,Liu LY,Yao X,Lee LP,Lee T
A-11122 was used in immunohistochemistry determine the transcriptional networks that regulate the development of distinct neuroblast lineages in Drosophila
Mon Feb 01 00:00:00 UTC 2016
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Development (Cambridge, England)
Alexandrova S,Kalkan T,Humphreys P,Riddell A,Scognamiglio R,Trumpp A,Nichols J
A-11122 was used in immunohistochemistry to elucidate embryonic stem cell integration for selection and dynamics in early mouse embryos
Fri Jan 01 00:00:00 UTC 2016
Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster.
Development (Cambridge, England)
Mavor LM,Miao H,Zuo Z,Holly RM,Xie Y,Loerke D,Blankenship JT
A-11122 was used in Immunocytochemistry to show that Rab8 has striking dynamic behaviours in vivo.
Tue Mar 01 00:00:00 UTC 2016
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang Q,Gao X,Li C,Feliciano C,Wang D,Zhou D,Mei Y,Monteiro P,Anand M,Itohara S,Dong X,Fu Z,Feng G
A-11122 was used in Immunohistochemistry to study the neurobiological function of SORBS2 in the brain.
Wed Feb 17 00:00:00 UTC 2016
Effects of Optogenetic Activation of Corticothalamic Terminals in the Motor Thalamus of Awake Monkeys.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Galvan A,Hu X,Smith Y,Wichmann T
A-11122 was used in immunohistochemistry - free floating to analyze optogenetic activation of corticothalamic terminals effects in the motor thalamus of awake monkeys
Wed Mar 23 00:00:00 UTC 2016
Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fame RM,MacDonald JL,Dunwoodie SL,Takahashi E,Macklis JD
A-11122 was used in Immunocytochemistry to identify Cited2 as a novel subtype-specific and area-specific regulator of development of distinct subpopulations within the broad population of callosal projection neurons.
Wed Jun 15 00:00:00 UTC 2016
Sensory Cortical Activity Is Related to the Selection of a Rhythmic Motor Action Pattern.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Li JX,Maier JX,Reid EE,Katz DB
A-11122 was used in immunohistochemistry to study the relationship between selection of a rhythmic motor action pattern and sensory cortical activity
Wed May 18 00:00:00 UTC 2016
Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Drerup CM,Lusk S,Nechiporuk A
A-11122 was used in Immunohistochemistry to provide conclusive evidence that this defect results from disruption of anterograde transport of SCG10.
Wed Jun 29 00:00:00 UTC 2016
The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons.
Sleep
Cavanaugh DJ,Vigderman AS,Dean T,Garbe DS,Sehgal A
A-11122 was used in Immunohistochemistry to study the mechanisms through which the circadian system modulates sleep.
Mon Feb 01 00:00:00 UTC 2016
A novel mutant Na+ /HCO3- cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis.
The Journal of physiology
Myers EJ,Yuan L,Felmlee MA,Lin YY,Jiang Y,Pei Y,Wang O,Li M,Xing XP,Marshall A,Xia WB,Parker MD
A-11122 was used in immunocytochemistry to study a novel mutant Na(+)/HCO3(-) cotransporter NBCe1 found in a case of proximal renal tubular acidosis with compound-heterozygous inheritance
Tue Nov 01 00:00:00 UTC 2016
Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion.
Journal of immunology (Baltimore, Md. : 1950)
Nath S,Christian L,Tan SY,Ki S,Ehrlich LI,Poenie M
A-11122 was used in Western Blot to conclude that the NDE1/Lissencephaly 1 and dynactin complexes separately mediate two key components of T cell-focused secretion, namely translocation of the MTOC and lytic granules to the IS, respectively.
Thu Sep 15 00:00:00 UTC 2016
Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis.
Journal of cell science
Toshima JY,Horikomi C,Okada A,Hatori MN,Nagano M,Masuda A,Yamamoto W,Siekhaus DE,Toshima J
A-11122 was used in western blot to determine the role of Srv2/CAP in polarized actin cable assembly and patch internalization during endocytosis
Fri Jan 15 00:00:00 UTC 2016
DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Journal of cell science
Francia S,Cabrini M,Matti V,Oldani A,d'Adda di Fagagna F
A-11122 was used in western blot to suggest that that DICER, DROSHA, and DDRNAs recruit DNA damage factors
Fri Apr 01 00:00:00 UTC 2016
Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells.
Journal of cell science
Suli A,Pujol R,Cunningham DE,Hailey DW,Prendergast A,Rubel EW,Raible DW
A-11122 was used in Immunohistochemistry to study the effect of post-synaptic elements on ribbon formation and maintenance in the zebra fish lateral line system.
Wed Jun 01 00:00:00 UTC 2016
Flagellar pocket restructuring through the Leishmania life cycle involves a discrete flagellum attachment zone.
Journal of cell science
Wheeler RJ,Sunter JD,Gull K
A-11122 was used in western blot to characterize a discrete flagellum attachment zone found in the Leishmania life cycle during flagellar pocket restructuring
Mon Feb 15 00:00:00 UTC 2016
FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency.
Human molecular genetics
Ruparelia AA,Oorschot V,Ramm G,Bryson-Richardson RJ
A-11122 was used in immunohistochemistry to study impairment of autophagy and protein insufficiency due to FLNC myofibrillar myopathy
Wed Jun 01 00:00:00 UTC 2016
SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons.
Human molecular genetics
Patitucci TN,Ebert AD
A-11122 was used in Immunocytochemistry to study if oxidative stress contributes to spinal muscular atrophy (SMA) astrocyte pathology.
Mon Feb 01 00:00:00 UTC 2016
Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish.
Journal of immunology research
Ulloa PE,Solís CJ,De la Paz JF,Alaurent TG,Caruffo M,Hernández AJ,Dantagnan P,Feijóo CG
A-11122 was used in immunohistochemistry to research intestinal inflammation decrease triggered by a soybean meal-based diet in zebrafish
Mon Mar 06 00:00:00 UTC 2017
Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster.
Genetics
Lin CC,Potter CJ
A-11122 was used in immunohistochemistry to utilize inducible gene replacement in drosophila melanogaster to edit transgenic DNA components
Mon Aug 01 00:00:00 UTC 2016
Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function.
Gene
Marks M,Pennimpede T,Lange L,Grote P,Herrmann BG,Wittler L
A-11122 was used in immunocytochemistry to investigate the role and localization of Fam181b and Fam181a.
Sun Jan 10 00:00:00 UTC 2016
Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly.
Molecular biology of the cell
Lyon AS,Morin G,Moritz M,Yabut KC,Vojnar T,Zelter A,Muller E,Davis TN,Agard DA
A-11122 was used in western blot to investigate the drive of gamma-tubulin ring complex assembly due to higher-order oligomerization of Spc110p
Fri Jul 15 00:00:00 UTC 2016
Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis.
Molecular biology of the cell
Mishra PK,Ciftci-Yilmaz S,Reynolds D,Au WC,Boeckmann L,Dittman LE,Jowhar Z,Pachpor T,Yeh E,Baker RE,Hoyt MA,D'Amours D,Bloom K,Basrai MA
A-11122 was used in immunoprecipitation and western blot to study the association with cetromeres to facilitate the removal of centromeric cohesis during mitosis with polo kinase Cdc5
Fri Jul 15 00:00:00 UTC 2016
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
Molecular biology of the cell
Qadota H,Mayans O,Matsunaga Y,McMurry JL,Wilson KJ,Kwon GE,Stanford R,Deehan K,Tinley TL,Ngwa VM,Benian GM
A-11122 was used in immunocytochemistry identify binding partners of UNC-89
Sun May 15 00:00:00 UTC 2016
Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X.
Brain research
Gotts J,Atkinson L,Yanagawa Y,Deuchars J,Deuchars SA
A-11122 was used in immunohistochemistry study the enzymes involved in GABA and acetylcholine production in the lamina X
Thu Sep 01 00:00:00 UTC 2016
Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro.
Developmental and comparative immunology
Brietzke A,Arnemo M,Gjøen T,Rebl H,Korytář T,Goldammer T,Rebl A,Seyfert HM
A-11122 was used in western blot to study Tlr2 using rainbow trout
Fri Jan 01 00:00:00 UTC 2016
Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System.
Frontiers in neuroanatomy
Ortega-de San Luis C,Pascual A
A-11122 was used in immunohistochemistry to characterize the mouse central nervous system by simultaneous detection of both GFRalpha1 and GDNF expression patterns
Fri Jul 22 00:00:00 UTC 2016
CRASP: CFP reconstitution across synaptic partners.
Biochemical and biophysical research communications
Li Y,Guo A,Li H
A-11122 was used in immunocytochemistry and immunohistochemistry to characterize CRASP (CFP reconstitution across synaptic partners)
Fri Jan 15 00:00:00 UTC 2016
Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice.
Developmental biology
Noda K,Mishina Y,Komatsu Y
A-11122 was used in immunohistochemistry (frozen) to demonstrate that enhanced BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice.
Fri Jul 15 00:00:00 UTC 2016
Bhlhb5::flpo allele uncovers a requirement for Bhlhb5 for the development of the dorsal cochlear nucleus.
Developmental biology
Cai X,Kardon AP,Snyder LM,Kuzirian MS,Minestro S,de Souza L,Rubio ME,Maricich SM,Ross SE
A-11122 was used in immunohistochemistry - frozen section to discover the requirement for Bhlhb5 for the development of the dorsal cochlear nucleus by the Bhlhb5:flpo allele
Wed Jun 15 00:00:00 UTC 2016
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.
Developmental biology
Huettl RE,Eckstein S,Stahl T,Petricca S,Ninkovic J,Götz M,Huber AB
A-11122 was used in immunohistochemistry to investigate the role of Pax6 in neuronal development.
Sun May 01 00:00:00 UTC 2016
High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.
The Journal of comparative neurology
Condro MC,Matynia A,Foster NN,Ago Y,Rajbhandari AK,Van C,Jayaram B,Parikh S,Diep AL,Nguyen E,May V,Dong HW,Waschek JA
A-11122 was used in immunohistochemistry - frozen section to characterize mapping of PACAP-expressing neurons in high resolution with a PACAP-EGFP transgenic mouse model
Thu Dec 15 00:00:00 UTC 2016
Synaptic circuitry of identified neurons in the antennal lobe of Drosophila melanogaster.
The Journal of comparative neurology
Rybak J,Talarico G,Ruiz S,Arnold C,Cantera R,Hansson BS
A-11122 was used in Immunohistochemistry to help study serial sections of three glomeruli using electron microscopy.
Wed Jun 15 00:00:00 UTC 2016
Interstitial branch formation within the red nucleus by deep cerebellar nuclei-derived commissural axons during target recognition.
The Journal of comparative neurology
Hara S,Kaneyama T,Inamata Y,Onodera R,Shirasaki R
A-11122 was used in immunohistochemistry to elucidate how commissural axons recognize their targets after crossing the midline.
Fri Apr 01 00:00:00 UTC 2016
Optogenetic spatial and temporal control of cortical circuits on a columnar scale.
Journal of neurophysiology
Roy A,Osik JJ,Ritter NJ,Wang S,Shaw JT,Fiser J,Van Hooser SD
A-11122 was used in immunohistochemistry to characterize temporal and spatial control of cortical circuits
Mon Feb 01 00:00:00 UTC 2016
Mushroom body signaling is required for locomotor activity rhythms in Drosophila.
Neuroscience research
Mabuchi I,Shimada N,Sato S,Ienaga K,Inami S,Sakai T
A-11122 was used in immunohistochemistry to articulate the requirement for locomotor activity rhythms in drosophila by mushroom body signaling
Sat Oct 01 00:00:00 UTC 2016
A novel interaction between ATOH8 and PPP3CB.
Histochemistry and cell biology
Chen J,Balakrishnan-Renuka A,Hagemann N,Theiss C,Chankiewitz V,Chen J,Pu Q,Erdmann KS,Brand-Saberi B
A-11122 was used in western blot to characterize the interaction between pPP3CB and ATOH8
Fri Jan 01 00:00:00 UTC 2016
KHARON Is an Essential Cytoskeletal Protein Involved in the Trafficking of Flagellar Membrane Proteins and Cell Division in African Trypanosomes.
The Journal of biological chemistry
Sanchez MA,Tran KD,Valli J,Hobbs S,Johnson E,Gluenz E,Landfear SM
A-11122 was used in Immunocytochemistry to identify, using T. brucei as a model, the cytoskeletal protein KHARON as an essential component of flagellar membrane transport machinery and cell division.
Fri Sep 16 00:00:00 UTC 2016
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
Nature communications
Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S
A-11122 was used in immunohistochemistry determine the function of MRF4 in adult skeletal muscle
Wed Aug 03 00:00:00 UTC 2016
Wnt pathway activation by ADP-ribosylation.
Nature communications
Yang E,Tacchelly-Benites O,Wang Z,Randall MP,Tian A,Benchabane H,Freemantle S,Pikielny C,Tolwinski NS,Lee E,Ahmed Y
A-11122 was used in Immunohistochemistry to demonstrate that the pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells.
Tue May 03 00:00:00 UTC 2016
A strategy to discover new organizers identifies a putative heart organizer.
Nature communications
Anderson C,Khan MAF,Wong F,Solovieva T,Oliveira NMM,Baldock RA,Tickle C,Burt DW,Stern CD
A-11122 was used in immunohistochemistry - paraffin section use chick embryos to show that the anterior intestinal portal endoderm is a heart organizer
Thu Aug 25 00:00:00 UTC 2016
Inhibition by Somatostatin Interneurons in Olfactory Cortex.
Frontiers in neural circuits
Large AM,Kunz NA,Mielo SL,Oswald AM
A-11122 was used in immunocytochemistry assess the effects of inhibition mediated by somatostatin interneurons onto pyramidal cells, parvalbumin interneurons, and other interneuron classes
Mon Oct 23 00:00:00 UTC 2017
Convergence of multimodal sensory pathways to the mushroom body calyx in Drosophila melanogaster.
Scientific reports
Yagi R,Mabuchi Y,Mizunami M,Tanaka NK
A-11122 was used in Immunohistochemistry to analyse the connectivity patterns between the primary sensory centers and mushroom body calyx in Drosophila melanogaster.
Mon Jul 11 00:00:00 UTC 2016
In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains.
Neural development
Reichert MC,Brown HE,Evans TA
A-11122 was used in immunohistochemistry determine the contribution of different conserved Robo domains to midline repulsive signaling
Thu Aug 18 00:00:00 UTC 2016
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Oncogene
Martinelli GB,Olivari D,Re Cecconi AD,Talamini L,Ottoboni L,Lecker SH,Stretch C,Baracos VE,Bathe OF,Resovi A,Giavazzi R,Cervo L,Piccirillo R
A-11122 was used in Western Blotting to support the idea that activating the CXCR4 pathway in muscle suppresses the deleterious wasting associated with cancer.
Thu Dec 01 00:00:00 UTC 2016
Genetically and functionally defined NTS to PBN brain circuits mediating anorexia.
Nature communications
Roman CW,Derkach VA,Palmiter RD
A-11122 was used in Immunohistochemistry to reveal that CCK and DBH neurons in the NTS directly engage CGRP(PBN) neurons to promote anorexia.
Wed Jun 15 00:00:00 UTC 2016
Methods for Studying Movement of Molecules Within Cilia.
Methods in molecular biology (Clifton, N.J.)
Lechtreck KF
A-11122 was used in Western Blot to analyze protein transport in the flagella of the unicellular alga Chlamydomonas reinhardtii, a widely used model for cilia and cilia-related disease.
Fri Jan 12 00:00:00 UTC 2018
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism.
Nature communications
Yang Y,Zhang Y,Iwamoto H,Hosaka K,Seki T,Andersson P,Lim S,Fischer C,Nakamura M,Abe M,Cao R,Skov PV,Chen F,Chen X,Lu Y,Nie G,Cao Y
A-11122 was used in immunohistochemistry - paraffin section describe anti-VEGF cessation-induced metastasis
Thu Sep 01 00:00:00 UTC 2016
SET DOMAIN GROUP 708, a histone H3 lysine 36-specific methyltransferase, controls flowering time in rice (Oryza sativa).
The New phytologist
Liu B,Wei G,Shi J,Jin J,Shen T,Ni T,Shen WH,Yu Y,Dong A
A-11122 was used in ChIP assay to indicate that H3K36me1, H3K36me2, and H3K36me3 levels were reduced at these loci in SDG708-deficient plants.
Fri Apr 01 00:00:00 UTC 2016
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.
Nature communications
Petridou NI,Skourides PA
A-11122 was used in immunohistochemistry to elucidate how spindle orientation occurs through a ligand-independent intgrin beta 1 mechanosensory complex
Tue Mar 08 00:00:00 UTC 2016
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation.
Nature communications
Liu Z,Ning G,Xu R,Cao Y,Meng A,Wang Q
A-11122 was used in immunohistochemistry identify Fscn1 as a molecular linker between TGF-beta receptors and actin filaments
Mon Aug 22 00:00:00 UTC 2016
A novel subset of enteric neurons revealed by ptf1a:GFP in the developing zebrafish enteric nervous system.
Genesis (New York, N.Y. : 2000)
Uribe RA,Gu T,Bronner ME
A-11122 was used in Immunocytochemistry to identify a novel population of neurons within the enteric nervous system of zebrafish larvae that express the transgenic marker ptf1a:GFP within the midgut.
Tue Mar 01 00:00:00 UTC 2016
Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?
PloS one
den Haan MC,van Zuylen VL,Pluijmert NJ,Schutte CI,Fibbe WE,Schalij MJ,Roelofs H,Atsma DE
A-11122 was used in immunohistochemistry - paraffin section to determine if animal models are robust enough due to the discrepant results of experimental human mesenchymal stromal cell therapy after myocardial infection
Fri Aug 26 00:00:00 UTC 2016
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
PLoS genetics
Hong CJ,Hamilton BA
A-11122 was used in Western Blotting to define Zfp423 deficiency as a bona fide ciliopathy, acting upstream of Shh signaling, and indicate a mechanism intrinsic to granule cell precursors for the resulting cerebellar hypoplasia.
Sat Oct 01 00:00:00 UTC 2016
Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum.
Nature communications
Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H
A-11122 was used in immunohistochemistry to investigate collateral sprouting in the adult brain
Wed Sep 21 00:00:00 UTC 2016
β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.
Nature cell biology
Eichel K,Jullié D,von Zastrow M
A-11122 was used in Immunocytochemistry to propose a β-arrestin signalling cycle that is catalytically activated by the GPCR and energetically coupled to the endocytic machinery.
Tue Mar 01 00:00:00 UTC 2016
Defining the clonal dynamics leading to mouse skin tumour initiation.
Nature
Sánchez-Danés A,Hannezo E,Larsimont JC,Liagre M,Youssef KK,Simons BD,Blanpain C
A-11122 was used in Immunohistochemistry to assess the effect of oncogenic hedgehog signalling in distinct cell populations and their capacity to induce basal cell carcinoma, the most frequent cancer in humans, using skin epidermis as a model.
Thu Aug 18 00:00:00 UTC 2016
A transcription factor hierarchy defines an environmental stress response network.
Science (New York, N.Y.)
Song L,Huang SC,Wise A,Castanon R,Nery JR,Chen H,Watanabe M,Thomas J,Bar-Joseph Z,Ecker JR
A-11122 was used in ChIP assay to identify a new family of transcriptional regulators modulating abscisic acid (ABA) and salt responsiveness and demonstrated their utility to modulate plant resilience to osmotic stress.
Fri Nov 04 00:00:00 UTC 2016
Organization of descending neurons in Drosophila melanogaster.
Scientific reports
Hsu CT,Bhandawat V
A-11122 was used in immunohistochemistry to analyze Drosophila melanogaster and the organization of descending neurons
Wed Feb 03 00:00:00 UTC 2016
Domain-specific functions of Stardust in Drosophila embryonic development.
Royal Society open science
Koch L,Feicht S,Sun R,Sen A,Krahn MP
A-11122 was used in Immunohistochemistry to conclude that the GUK domain plays an important role for the protein's function, which is not directly linked to Crumbs stabilization, and the L27N domain is essential for epithelial polarization independently of recruiting PATJ.
Tue Nov 01 00:00:00 UTC 2016
Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pierron M,Pinan-Lucarré B,Bessereau JL
A-11122 was used in Immunohistochemistry-immunofluorescence to provide the first evidence that an RSU-1-dependent active mechanism maintains extrasynaptic receptors dispersed and indirectly regulates synapse maturation.
Wed Jun 15 00:00:00 UTC 2016
Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice.
Hepatology research : the official journal of the Japan Society of Hepatology
Yanagida A,Mizuno N,Yamazaki Y,Kato-Itoh M,Umino A,Sato H,Ito K,Yamaguchi T,Nakauchi H,Kamiya A
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate an in vivo model to analyze hepatoblast bipotency and proliferative ability.
Fri Jul 01 00:00:00 UTC 2016
A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types.
eLife
Shima Y,Sugino K,Hempel CM,Shima M,Taneja P,Bullis JB,Mehta S,Lois C,Nelson SB
A-11122 was used in immunohistochemistry identify neuron-specific drivers to study select subsets of cells in mice
Mon Mar 21 00:00:00 UTC 2016
A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain.
Nature communications
Huang XY,Deng F,Yamaji N,Pinson SR,Fujii-Kashino M,Danku J,Douglas A,Guerinot ML,Salt DE,Ma JF
A-11122 was used in immunohistochemistry and western blot study copper accumulate in rice
Fri Jul 08 00:00:00 UTC 2016
Enrichment of hydroxylated C24- and C26-acyl-chain sphingolipids mediates PIN2 apical sorting at trans-Golgi network subdomains.
Nature communications
Wattelet-Boyer V,Brocard L,Jonsson K,Esnay N,Joubès J,Domergue F,Mongrand S,Raikhel N,Bhalerao RP,Moreau P,Boutté Y
A-11122 was used in Immunoprecipitation to reveal a role for the length of acyl chains of sphingolipids for polar sorting of proteins at the trans-Golgi network.
Thu Sep 29 00:00:00 UTC 2016
Immunodetection of Human LINE-1 Expression in Cultured Cells and Human Tissues.
Methods in molecular biology (Clifton, N.J.)
Sharma R,Rodić N,Burns KH,Taylor MS
A-11122 was used in Immunocytochemistry to describe detection of tagged LINE-1 ORF2p via immunofluorescence.
Tue Dec 13 00:00:00 UTC 2016
EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.
The Journal of comparative neurology
Son AI,Hashimoto-Torii K,Rakic P,Levitt P,Torii M
A-11122 was used in Immunohistochemistry to provide new evidence that Eph receptors in the same subfamily are not simply interchangeable but are functionally specified through selective interactions with distinct ligands in vivo.
Fri Jul 01 00:00:00 UTC 2016
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.
Nature communications
Lin SC,Kao CY,Lee HJ,Creighton CJ,Ittmann MM,Tsai SJ,Tsai SY,Tsai MJ
A-11122 was used in Immunohistochemistry to highlight the contribution of specific miRNAs through the regulation of the COUP-TFII-FOXM1-CENPF cascade in PCa metastasis and drug resistance.
Mon Apr 25 00:00:00 UTC 2016
Super-complexes of adhesion GPCRs and neural guidance receptors.
Nature communications
Jackson VA,Mehmood S,Chavent M,Roversi P,Carrasquero M,Del Toro D,Seyit-Bremer G,Ranaivoson FM,Comoletti D,Sansom MS,Robinson CV,Klein R,Seiradake E
A-11122 was used in immunoprecipitation to analyze neural guidance receptors and super-complexes of adhesion GPCRs
Tue Apr 19 00:00:00 UTC 2016
Doublesex Regulates the Connectivity of a Neural Circuit Controlling Drosophila Male Courtship Song.
Developmental cell
Shirangi TR,Wong AM,Truman JW,Stern DL
A-11122 was used in Immunohistochemistry to demonstrate how a sexual differentiation gene can build a sex-specific circuit motif by modulating neuronal arborization.
Mon Jun 20 00:00:00 UTC 2016
Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology.
Scientific reports
Raiss CC,Braun TS,Konings IB,Grabmayr H,Hassink GC,Sidhu A,le Feber J,Bausch AR,Jansen C,Subramaniam V,Claessens MM
A-11122 was used in western blot to provide insight into Parkinson's disease pathology by functionally different alpha-synuclein inclusions
Thu Mar 17 00:00:00 UTC 2016
Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells.
Nature communications
Lin C,Schuster M,Guimaraes SC,Ashwin P,Schrader M,Metz J,Hacker C,Gurr SJ,Steinberg G
A-11122 was used in immunocytochemistry to study the opposition of myosin forces to position organelles in cells by active diffusion and microtubule-based transport
Thu Jun 02 00:00:00 UTC 2016
Transgenic GDNF Positively Influences Proliferation, Differentiation, Maturation and Survival of Motor Neurons Produced from Mouse Embryonic Stem Cells.
Frontiers in cellular neuroscience
Cortés D,Robledo-Arratia Y,Hernández-Martínez R,Escobedo-Ávila I,Bargas J,Velasco I
A-11122 was used in immunocytochemistry demonstrate that glial cell line-derived neurotrophic factor promotes proliferation of motor neuron-committed precursors, stimulates neuronal differentiation, enhances maturation, and conveys neuroprotection
Tue Sep 27 00:00:00 UTC 2016
The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.
BMC biology
Ho AK,Wagstaff JL,Manna PT,Wartosch L,Qamar S,Garman EF,Freund SM,Roberts RC
A-11122 was used in Immunocytochemistry to characterise the properties of LITAF and describe its interactions with PE in Charcot-Marie-Tooth disease type 1C.
Wed Dec 07 00:00:00 UTC 2016
Foxn4 promotes gene expression required for the formation of multiple motile cilia.
Development (Cambridge, England)
Campbell EP,Quigley IK,Kintner C
A-11122 was used in ChIP assay to indicate that Foxn4 complements Foxj1 transcriptionally during MCC differentiation, thereby shaping the levels of gene expression required for the timely and complete biogenesis of multiple motile cilia.
Thu Dec 15 00:00:00 UTC 2016
The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.
eLife
Ju XC,Hou QQ,Sheng AL,Wu KY,Zhou Y,Jin Y,Wen T,Yang Z,Wang X,Luo ZG
A-11122 was used in immunohistochemistry - frozen section determine the contribution of TBC1D3 to cortical folding
Tue Aug 09 00:00:00 UTC 2016
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kramer M,Ribeiro D,Arsenian-Henriksson M,Deller T,Rohrer H
A-11122 was used in Immunocytochemistry to demonstrate that MYCN increases proliferation but not survival, whereas long-term expression of ALKF1174L elicits cell-cycle exit, differentiation, and survival of postmitotic neurons.
Wed Oct 05 00:00:00 UTC 2016
Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
Nature
Kim J,Ishiguro K,Nambu A,Akiyoshi B,Yokobayashi S,Kagami A,Ishiguro T,Pendas AM,Takeda N,Sakakibara Y,Kitajima TS,Tanno Y,Sakuno T,Watanabe Y
A-11122 was used in immunocytochemistry to search for a conserved mechanism for meiotic kinetochore regulation and identify MEIKIN in mice
Thu Jan 22 00:00:00 UTC 2015
Improved and expanded Q-system reagents for genetic manipulations.
Nature methods
Riabinina O,Luginbuhl D,Marr E,Liu S,Wu MN,Luo L,Potter CJ
A-11122 was used in immunohistochemistry to generate QF2, Gal4QF and LexAQF chimeric transcriptional activators to enhance the toolkit available for transgenic regulation in Drosophila melanogaster
Sun Mar 01 00:00:00 UTC 2015
LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice.
Gastroenterology
Kondo J,Powell AE,Wang Y,Musser MA,Southard-Smith EM,Franklin JL,Coffey RJ
A-11122 was used in immunohistochemistry to test if LRIG1 contributes to the ontogeny of interstitial cells of Cajal in the small and large intestines.
Sat Aug 01 00:00:00 UTC 2015
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nature immunology
Finkin S,Yuan D,Stein I,Taniguchi K,Weber A,Unger K,Browning JL,Goossens N,Nakagawa S,Gunasekaran G,Schwartz ME,Kobayashi M,Kumada H,Berger M,Pappo O,Rajewsky K,Hoshida Y,Karin M,Heikenwalder M,Ben-Neriah Y,Pikarsky E
A-11122 was used in immunohistochemistry - paraffin section to study hepatocellular carcinoma and ectopic lymphoid structures function as microniches for tumor progenitor cells
Tue Dec 01 00:00:00 UTC 2015
Optogenetic acidification of synaptic vesicles and lysosomes.
Nature neuroscience
Rost BR,Schneider F,Grauel MK,Wozny C,Bentz C,Blessing A,Rosenmund T,Jentsch TJ,Schmitz D,Hegemann P,Rosenmund C
A-11122 was used in Immunocytochemistry to present a targeting strategy to selectively express the light-driven proton pump Arch3 on synaptic vesicles.
Tue Dec 01 00:00:00 UTC 2015
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Nature neuroscience
Siegert S,Seo J,Kwon EJ,Rudenko A,Cho S,Wang W,Flood Z,Martorell AJ,Ericsson M,Mungenast AE,Tsai LH
A-11122 was used in Immunohistochemistry to provide new insight into the mechanism by which miR-137 dysregulation can impair synaptic plasticity in the hippocampus.
Wed Jul 01 00:00:00 UTC 2015
Niche appropriation by Drosophila intestinal stem cell tumours.
Nature cell biology
Patel PH,Dutta D,Edgar BA
A-11122 was used in immunohistochemistry - paraffin section to use Drosophilia to investigate how loss of differentiation initiates tumorigenesis
Tue Sep 01 00:00:00 UTC 2015
C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.
Neuron
Tu H,Pinan-Lucarré B,Ji T,Jospin M,Bessereau JL
A-11122 was used in Immunohistochemistry-immunofluorescence to show that the Ce-Punctin secreted by GABAergic motor neurons controls the clustering of GABA(A)Rs through the synaptic adhesion molecule neuroligin and the netrin receptor UNC-40/DCC.
Wed Jun 17 00:00:00 UTC 2015
Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function.
Acta neuropathologica
Sztal TE,Zhao M,Williams C,Oorschot V,Parslow AC,Giousoh A,Yuen M,Hall TE,Costin A,Ramm G,Bird PI,Busch-Nentwich EM,Stemple DL,Currie PD,Cooper ST,Laing NG,Nowak KJ,Bryson-Richardson RJ
A-11122 was used in immunohistochemistry - frozen section to study the formation of nemaline bodies and their role in myopathy
Tue Sep 01 00:00:00 UTC 2015
Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy.
EMBO molecular medicine
Dejanovic B,Djémié T,Grünewald N,Suls A,Kress V,Hetsch F,Craiu D,Zemel M,Gormley P,Lal D,Myers CT,Mefford HC,Palotie A,Helbig I,Meier JC,De Jonghe P,Weckhuysen S,Schwarz G
A-11122 was used in immunocytochemistry, immunoprecipitation, and western blot to describe a missense mutation that affects both functions of gephyrin
Tue Dec 01 00:00:00 UTC 2015
A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function.
EMBO molecular medicine
Okray Z,de Esch CE,Van Esch H,Devriendt K,Claeys A,Yan J,Verbeeck J,Froyen G,Willemsen R,de Vrij FM,Hassan BA
A-11122 was used in immunohistochemistry to identify and characterize a novel FMR1 mutation.
Wed Apr 01 00:00:00 UTC 2015
FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.
The EMBO journal
Jacobi A,Loy K,Schmalz AM,Hellsten M,Umemori H,Kerschensteiner M,Bareyre FM
A-11122 was used in immunohistochemistry to identify FGF22 as a regulator of circuit remodeling in the injured spinal cord.
Tue May 05 00:00:00 UTC 2015
piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.
Developmental cell
Phillips CM,Brown KC,Montgomery BE,Ruvkun G,Montgomery TA
A-11122 was used in Immunohistochemistry to uncover a role for piRNAs in protecting essential genes from RNA silencing.
Mon Aug 24 00:00:00 UTC 2015
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.
Autophagy
Shen WC,Li HY,Chen GC,Chern Y,Tu PH
A-11122 was used in immunocytochemistry to elucidate how optineurin contributes to disease
Fri Apr 03 00:00:00 UTC 2015
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Genes & development
Chong YC,Mann RK,Zhao C,Kato M,Beachy PA
A-11122 was used in immunoprecipitation to elucidate the role of Dlg5 in hedgehog signaling.
Sun Feb 01 00:00:00 UTC 2015
Sensory determinants of behavioral dynamics in Drosophila thermotaxis.
Proceedings of the National Academy of Sciences of the United States of America
Klein M,Afonso B,Vonner AJ,Hernandez-Nunez L,Berck M,Tabone CJ,Kane EA,Pieribone VA,Nitabach MN,Cardona A,Zlatic M,Sprecher SG,Gershow M,Garrity PA,Samuel AD
A-11122 was used in immunocytochemistry to examine Drosophila larva navigation up temperature gradients
Tue Jan 13 00:00:00 UTC 2015
Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America
Chen Y,Bharill S,Isacoff EY,Chalfie M
A-11122 was used in immunohistochemistry to characterize the subunit composition of a DEG/ENaC Caenorhabditis elegans mechanosensory channel
Tue Sep 15 00:00:00 UTC 2015
The ASYMMETRIC LEAVES Complex Employs Multiple Modes of Regulation to Affect Adaxial-Abaxial Patterning and Leaf Complexity.
The Plant cell
Husbands AY,Benkovics AH,Nogueira FT,Lodha M,Timmermans MC
A-11122 was used in ChIP assay to determine leaf complexity and adaxial-abaxial patterning due to the assymmetric leaves complex
Tue Dec 01 00:00:00 UTC 2015
Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Molecular therapy. Nucleic acids
Takahashi M,Suzuki M,Fukuoka M,Fujikake N,Watanabe S,Murata M,Wada K,Nagai Y,Hohjoh H
A-11122 was used in western blot to use an atypical RNAi to moderately suppress alpha-synuclein gene expression.
Tue May 12 00:00:00 UTC 2015
δ-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice.
British journal of pharmacology
Laurent V,Wong FL,Balleine BW
A-11122 was used in immunohistochemistry to study the role of theta-opioid receptors in decision making in the accumbens shell.
Thu Jan 01 00:00:00 UTC 2015
The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium.
Cellular and molecular life sciences : CMLS
Rais Y,Reich A,Simsa-Maziel S,Moshe M,Idelevich A,Kfir T,Miosge N,Monsonego-Ornan E
A-11122 was used in immunocytochemistry and western blot to investigate the effect of mechanical load on ciliogenesis in the growth plate.
Sun Feb 01 00:00:00 UTC 2015
Reward signal in a recurrent circuit drives appetitive long-term memory formation.
eLife
Ichinose T,Aso Y,Yamagata N,Abe A,Rubin GM,Tanimoto H
A-11122 was used in immunohistochemistry to research the drive for appetitive long-term memory formation by a reward signal in a recurrent circuit
Tue Nov 17 00:00:00 UTC 2015
Subversion of human intestinal mucosa innate immunity by a Crohn's disease-associated E. coli.
Mucosal immunology
Jarry A,Crémet L,Caroff N,Bou-Hanna C,Mussini JM,Reynaud A,Servin AL,Mosnier JF,Liévin-Le Moal V,Laboisse CL
A-11122 was used in immunohistochemistry - paraffin section to use a 3D model of the human intestinal mucosa to determine the effects of adherent-invasive Escherichia coli on the the inflammasome and NFkappaB signaling
Fri May 01 00:00:00 UTC 2015
Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex.
The Journal of cell biology
Coon BG,Baeyens N,Han J,Budatha M,Ross TD,Fang JS,Yun S,Thomas JL,Schwartz MA
A-11122 was used in immunohistochemistry and western blot to study the role of VE-cadherin in fluid shear stress
Mon Mar 30 00:00:00 UTC 2015
Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system.
Glia
Rao M,Nelms BD,Dong L,Salinas-Rios V,Rutlin M,Gershon MD,Corfas G
A-11122 was used in immunohistochemistry to characterize glia in enteric nervous system.
Sun Nov 01 00:00:00 UTC 2015
Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow.
Glia
Dumas L,Heitz-Marchaland C,Fouquet S,Suter U,Livet J,Moreau-Fauvarque C,Chédotal A
A-11122 was used in immunohistochemistry to use multicolor labeling technology to simultaneously individual oligodendrocytes in the postnatal mouse optic nerve.
Wed Apr 01 00:00:00 UTC 2015
Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.
Development (Cambridge, England)
Liu Z,Brunskill E,Boyle S,Chen S,Turkoz M,Guo Y,Grant R,Kopan R
A-11122 was used in immunohistochemistry (frozen) to characterize a mouse line where cells expressing low levels of Notch1 activation are marked.
Sun Mar 15 00:00:00 UTC 2015
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila.
Development (Cambridge, England)
Sun D,Buttitta L
A-11122 was used in immunohistochemistry to investigate how protein phosphatase type 2A complex suppresses tumors.
Tue Sep 01 00:00:00 UTC 2015
Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.
Development (Cambridge, England)
Lee J,Peng Y,Lin WY,Parrish JZ
A-11122 was used in immunohistochemistry and western blot to assess the developmental origin of subcompartments in axons and dendrites
Thu Jan 01 00:00:00 UTC 2015
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex.
Development (Cambridge, England)
Brás-Pereira C,Casares F,Janody F
A-11122 was used in Immunohistochemistry to demonstrate the role of human dachshund homolog DACH1 in tumorigenesis and suggest that DACH1 might prevent cellular transformation by limiting the oncogenic activity of YAP and/or TAZ.
Wed Apr 15 00:00:00 UTC 2015
The loss of Hh responsiveness by a non-ciliary Gli2 variant.
Development (Cambridge, England)
Liu J,Zeng H,Liu A
A-11122 was used in immunocytochemistry and western blot to study the effect of Gli2 ciliary localization on Hedgehog signaling
Fri May 01 00:00:00 UTC 2015
Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sanz E,Quintana A,Deem JD,Steiner RA,Palmiter RD,McKnight GS
A-11122 was used in immunohistochemistry to describe a method to examine the developmental pathways that link specific subtypes of neurons in mice
Wed Apr 08 00:00:00 UTC 2015
Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Matsumoto T,Nagasawa T,Mackay F,Murakami F
A-11122 was used in immunohistochemistry - frozen section to investigate mechanisms involved in maintaining radial glial scaffold integrity during development
Wed Jun 17 00:00:00 UTC 2015
Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Szabo NE,da Silva RV,Sotocinal SG,Zeilhofer HU,Mogil JS,Kania A
A-11122 was used in immunohistochemistry to study the roles of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits.
Wed Apr 01 00:00:00 UTC 2015
Preventive effect of oral mucosal epithelial cell sheets on intrauterine adhesions.
Human reproduction (Oxford, England)
Kuramoto G,Takagi S,Ishitani K,Shimizu T,Okano T,Matsui H
A-11122 was used in immunohistochemistry - paraffin section to test if oral mucosal epithelial cell sheets can be used to treat intrauterine adhesions.
Sun Feb 01 00:00:00 UTC 2015
Topology of Endoplasmic Reticulum-Associated Cellular and Viral Proteins Determined with Split-GFP.
Traffic (Copenhagen, Denmark)
Hyun SI,Maruri-Avidal L,Moss B
A-11122 was used in immunocytochemistry and western blot to study two vaccinia virus proteins, L2 and A30.5, in the ER.
Wed Jul 01 00:00:00 UTC 2015
Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.
The American journal of pathology
Wang Y,Shi C,Lu Y,Poulin EJ,Franklin JL,Coffey RJ
A-11122 was used in western blot to study duodenal adenomas in leucine-rich repeats and immunoglobulin-like domains 1 -/- mice.
Wed Apr 01 00:00:00 UTC 2015
Minimal sequence requirements for oligodeoxyribonucleotides activating human TLR9.
Journal of immunology (Baltimore, Md. : 1950)
Pohar J,Kužnik Krajnik A,Jerala R,Benčina M
A-11122 was used in western blot to determine the sequence motifs of B-class and C-class phosphodiester oligodeoxyribonucleotides that activate TLR9.
Wed Apr 15 00:00:00 UTC 2015
Species-Specific Minimal Sequence Motif for Oligodeoxyribonucleotides Activating Mouse TLR9.
Journal of immunology (Baltimore, Md. : 1950)
Pohar J,Lainšček D,Fukui R,Yamamoto C,Miyake K,Jerala R,Benčina M
A-11122 was used in western blot to identify the sequence motif of B class phosphodiester oligodeoxyribonucleotides that govern mouse TLR9 activation.
Sun Nov 01 00:00:00 UTC 2015
α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.
Journal of cell science
Escobar DJ,Desai R,Ishiyama N,Folmsbee SS,Novak MN,Flozak AS,Daugherty RL,Mo R,Nanavati D,Sarpal R,Leckband D,Ikura M,Tepass U,Gottardi CJ
A-11122 was used in immunocytochemistry to determine how intercellular adhesion occurs through alpha-catenin phosphorylation and a dual-kinase mechanism
Sun Mar 15 00:00:00 UTC 2015
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model.
Human molecular genetics
Cook C,Kang SS,Carlomagno Y,Lin WL,Yue M,Kurti A,Shinohara M,Jansen-West K,Perkerson E,Castanedes-Casey M,Rousseau L,Phillips V,Bu G,Dickson DW,Petrucelli L,Fryer JD
A-11122 was used in immunohistochemistry (paraffin) to characterize a new mouse model of tauopathy.
Sun Nov 01 00:00:00 UTC 2015
Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function.
Cellular signalling
Figeac N,Zammit PS
A-11122 was used in immunocytochemistry to study the relationship of Axin1, Axin2, and Wnt/beta-catenin signaling in satellite cells.
Sat Aug 01 00:00:00 UTC 2015
Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways.
Carcinogenesis
Cheung CT,Bendris N,Paul C,Hamieh A,Anouar Y,Hahne M,Blanchard JM,Lemmers B
A-11122 was used in western blot to investigate the pathways responsible for the epithelial-mesenchymal transition in cells deficient for Cyclin A2
Sat Aug 01 00:00:00 UTC 2015
Structure-function analyses of tyrosine phosphatase PTP69D in giant fiber synapse formation of Drosophila.
Molecular and cellular neurosciences
Lee LH,Godenschwege TA
A-11122 was used in immunohistochemistry to analyze structure function of tyrosine phosphatase PTP69D in formation of giant fiber synapse in Drosophila
Thu Jan 01 00:00:00 UTC 2015
An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila.
Genetics
Eisman RC,Phelps MA,Kaufman T
A-11122 was used in ChIP assay to investigate the formation of the pericentriolar matrix.
Thu Oct 01 00:00:00 UTC 2015
An enhanced gene targeting toolkit for Drosophila: Golic+.
Genetics
Chen HM,Huang Y,Pfeiffer BD,Yao X,Lee T
A-11122 was used in immunohistochemistry to describe a new method to generate designer genes: Gene targeting during Oogenesis with Lethality Inhibitor and CRISPR/Cas (Golic+).
Sun Mar 01 00:00:00 UTC 2015
Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy.
Gene therapy
Lachmann N,Brennig S,Hillje R,Schermeier H,Phaltane R,Dahlmann J,Gruh I,Heinz N,Schiedlmeier B,Baum C,Moritz T
A-11122 was used in western blot to investigate how to regulate transgene expression in viral gene therapy vectors + B937B900 : B953B900 : B956D95B900 : B92B900 : B957B900 : B956B900 : B955B900 : B954B900 : B953B900 : B952B900 : B95B900 : B952B900 : B95B900 : B950.
Sun Nov 01 00:00:00 UTC 2015
The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro.
Vaccine
Sala KA,Nishiura H,Upton LM,Zakutansky SE,Delves MJ,Iyori M,Mizutani M,Sinden RE,Yoshida S,Blagborough AM
A-11122 was used in immunocytochemistry to identify new targets for anti-malarial transmission-blocking vaccines.
Fri Jan 09 00:00:00 UTC 2015
Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon.
Cell and tissue research
Fleischer J,Bumbalo R,Bautze V,Strotmann J,Breer H
A-11122 was used in immunohistochemistry to study the role Olfr78 in the gastrointestinal tract
Tue Sep 01 00:00:00 UTC 2015
Depletion of Foxp3+ regulatory T cells increases severity of mechanical allodynia and significantly alters systemic cytokine levels following peripheral nerve injury.
Cytokine
Lees JG,Duffy SS,Perera CJ,Moalem-Taylor G
A-11122 was used in immunohistochemistry to investigate the role of Tregs in nerve injury-induced pain hypersensitivity.
Sun Feb 01 00:00:00 UTC 2015
The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase.
The Biochemical journal
Onyenwoke RU,Sexton JZ,Yan F,Díaz MC,Forsberg LJ,Major MB,Brenman JE
A-11122 was used in immunoprecipitation to propose a mechanism for how TOR activity regulates the TRPML1 channel.
Tue Sep 15 00:00:00 UTC 2015
Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse.
Neuroscience
Kim YS,Kim TH,McKemy DD,Bae YC
A-11122 was used in western blot to investigate the mechanism of TRPM8-mediated cold perception.
Thu Sep 10 00:00:00 UTC 2015
Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.
Molecular biology of the cell
Beaven R,Dzhindzhev NS,Qu Y,Hahn I,Dajas-Bailador F,Ohkura H,Prokop A
A-11122 was used in western blot to analyze a reduction of microtubule plus end association in the nervous system by Drosophila CLIP-190 and mammalian CLIP-170
Wed Apr 15 00:00:00 UTC 2015
Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.
Differentiation; research in biological diversity
Jarrar W,Vauti F,Arnold HH,Holz A
A-11122 was used in immunohistochemistry to study the effect of Nkx2.2 deletion in the nervous system
Thu Mar 10 00:00:00 UTC 2016
Wnt/ß-catenin signaling is required for radial glial neurogenesis following spinal cord injury.
Developmental biology
Briona LK,Poulain FE,Mosimann C,Dorsky RI
A-11122 was used in immunohistochemistry to investigate the role of Wnt/Beta-catenin signaling in spinal cord regeneration
Wed Jul 01 00:00:00 UTC 2015
PEG-PLA nanoparticles facilitate siRNA knockdown in adult zebrafish heart.
Developmental biology
Diao J,Wang H,Chang N,Zhou XH,Zhu X,Wang J,Xiong JW
A-11122 was used in immunohistochemistry to use nanoparticle-facilitated siRNA to knock down genes in the zebrafish heart
Thu Oct 15 00:00:00 UTC 2015
Exploring new gene integration sites for gene knock-in by gene-trapping strategy.
Transgenic research
Nanchi I,Yoshimura Y,Nakamura K,Masago Y,Ohbayashi T,Okuda T
A-11122 was used in immunohistochemistry - frozen section to identify new gene integration loci for gene knock-in studies.
Mon Jun 01 00:00:00 UTC 2015
Cux1 and Cux2 selectively target basal and apical dendritic compartments of layer II-III cortical neurons.
Developmental neurobiology
Cubelos B,Briz CG,Esteban-Ortega GM,Nieto M
A-11122 was used in immunohistochemistry to describe the role of Cux1 and Cux2 in apical and basal dendrite development
Sun Feb 01 00:00:00 UTC 2015
A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
Developmental neurobiology
Bian WJ,Miao WY,He SJ,Wan ZF,Luo ZG,Yu X
A-11122 was used in western blot to show that Frizzled4 signals downstream of Wnt5a to promote dendrite branching and growth.
Sat Aug 01 00:00:00 UTC 2015
Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.
The Journal of comparative neurology
Levy C,Brooks JM,Chen J,Su J,Fox MA
A-11122 was used in immunohistochemistry to study the expression of ADAMTS proteins in mouse hippocampus and neocortex
Sun Mar 01 00:00:00 UTC 2015
Changes in gene expression and cell shape characterise stages of epibranchial placode-derived neuron maturation in the chick.
Journal of anatomy
Smith AC,Fleenor SJ,Begbie J
A-11122 was used in immunohistochemistry to study the maturation of neurogenic placodes.
Wed Jul 01 00:00:00 UTC 2015
Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells.
Biology open
Shahab J,Tiwari MD,Honemann-Capito M,Krahn MP,Wodarz A
A-11122 was used in Immunohistochemistry to show that Baz is dispensable for the regulation of polarity in the follicular epithelium.
Fri Mar 13 00:00:00 UTC 2015
Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation.
Biology open
Pineault KM,Swinehart IT,Garthus KN,Ho E,Yao Q,Schipani E,Kozloff KM,Wellik DM
A-11122 was used in immunohistochemistry to examine the function of Hox11 in postnatal bone growth and patterning
Fri Oct 23 00:00:00 UTC 2015
Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.
Scientific reports
Park SJ,Jeong J,Park YU,Park KS,Lee H,Lee N,Kim SM,Kuroda K,Nguyen MD,Kaibuchi K,Park SK
A-11122 was used in immunoprecipitation to study the role disrupted-in-schizophrenia-1 in intracellular calcium signaling and schizophrenia pathogenesis.
Tue Mar 03 00:00:00 UTC 2015
Secondary taste neurons that convey sweet taste and starvation in the Drosophila brain.
Neuron
Kain P,Dahanukar A
A-11122 was used in Immunohistochemistry to provide a foundation for studying gustatory processing and its modulation by the internal nutrient state.
Wed Feb 18 00:00:00 UTC 2015
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest.
BMC cancer
Andries V,Vandepoele K,Staes K,Berx G,Bogaert P,Van Isterdael G,Ginneberge D,Parthoens E,Vandenbussche J,Gevaert K,van Roy F
A-11122 was used in western blot to test if NBPF1 is a tumor suppressor.
Sun May 10 00:00:00 UTC 2015
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing.
Nature communications
Garelli A,Heredia F,Casimiro AP,Macedo A,Nunes C,Garcez M,Dias ARM,Volonte YA,Uhlmann T,Caparros E,Koyama T,Gontijo AM
A-11122 was used in immunocytochemistry to study coupling growth with developmental timing by Dilp8 and the neuronal relaxin receptor Lgr3
Thu Oct 29 00:00:00 UTC 2015
Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adult Drosophila intestine.
Development (Cambridge, England)
Chen CH,Luhur A,Sokol N
A-11122 was used in Immunohistochemistry to identify Lin-28 as a stem cell intrinsic factor that boosts insulin signaling in intestinal progenitor cells and promotes their symmetric division in response to nutrients, defining a mechanism through which Lin-28 controls the adult stem cell division patterns that underlie tissue homeostasis and regeneration.
Thu Oct 15 00:00:00 UTC 2015
The N terminus of pro-endothelial monocyte-activating polypeptide II (EMAP II) regulates its binding with the C terminus, arginyl-tRNA synthetase, and neurofilament light protein.
The Journal of biological chemistry
Xu H,Malinin NL,Awasthi N,Schwarz RE,Schwarz MA
A-11122 was used in western blot to assess the role of the N terminus of pro-EMAP II in protein-protein interactions.
Fri Apr 10 00:00:00 UTC 2015
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area.
Nature neuroscience
Koo JW,Mazei-Robison MS,LaPlant Q,Egervari G,Braunscheidel KM,Adank DN,Ferguson D,Feng J,Sun H,Scobie KN,Damez-Werno DM,Ribeiro E,Peña CJ,Walker D,Bagot RC,Cahill ME,Anderson SA,Labonté B,Hodes GE,Browne H,Chadwick B,Robison AJ,Vialou VF,Dias C,Lorsch Z,Mouzon E,Lobo MK,Dietz DM,Russo SJ,Neve RL,Hurd YL,Nestler EJ
A-11122 was used in Immunohistochemistry to determine a persistent downregulation of exon-specific Bdnf expression in the ventral tegmental area in response to chronic opiate exposure, which was mediated by specific epigenetic modifications at the corresponding Bdnf gene promoters.
Sun Mar 01 00:00:00 UTC 2015
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
Nature communications
Iemura K,Tanaka K
A-11122 was used in immunohistochemistry and western blot to elucidate the contributions of Kid and CENP-E in chromosome congression.
Fri Mar 06 00:00:00 UTC 2015
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
Nature communications
Iemura K,Tanaka K
A-11122 was used in immunohistochemistry and western blot to elucidate the contributions of Kid and CENP-E in chromosome congression.
Fri Mar 06 00:00:00 UTC 2015
Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice.
PloS one
Tamura K,Minami K,Kudo M,Iemoto K,Takahashi H,Seino S
A-11122 was used in immunohistochemistry - paraffin section to determine the effect of liraglutide on beta cell fate and function
Wed Apr 06 00:00:00 UTC 2016
The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation.
The Journal of biological chemistry
Santarriaga S,Petersen A,Ndukwe K,Brandt A,Gerges N,Bruns Scaglione J,Scaglione KM
A-11122 was used in western blot to identify Dictyostelium as an organism that suppress aggregation of proteins with long polyglutamine tracts
Fri Oct 16 00:00:00 UTC 2015
Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model.
Thrombosis research
Peng X,Li J,Yu X,Tan R,Zhu L,Wang J,Wang R,Gu G,Liu Q,Ren L,Wang C,Hu Q
A-11122 was used in Immunohistochemistry to indicate serial-sectioning analysis method is necessary for evaluating APTE and provides strong evidences for BMSCs possessing therapeutic effectiveness against APTE, with female BMSCs superior to male counterparts.
Fri May 01 00:00:00 UTC 2015
Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density.
PloS one
Gurdziel K,Lorberbaum DS,Udager AM,Song JY,Richards N,Parker DS,Johnson LA,Allen BL,Barolo S,Gumucio DL
A-11122 was used in immunohistochemistry to assess and validate novel hedgehog-responsive enhancers by computational analysis prediction of Ci/Gli binding site density
Mon Jul 25 00:00:00 UTC 2016
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Neural development
Hoch RV,Clarke JA,Rubenstein JL
A-11122 was used in immunohistochemistry - frozen section to examine the lineages of Fgf8- versus Fgf17-expressing rostral patterning center cells
Tue Mar 31 00:00:00 UTC 2015
The Arabidopsis RCC1 Family Protein TCF1 Regulates Freezing Tolerance and Cold Acclimation through Modulating Lignin Biosynthesis.
PLoS genetics
Ji H,Wang Y,Cloix C,Li K,Jenkins GI,Wang S,Shang Z,Shi Y,Yang S,Li X
A-11122 was used in ChIP assay to analyze cold acclimation and freezing tolerance through modulating lignin biosynthesis regulated by arabidopsis RCC1 family protein TCF1
Fri Apr 29 00:00:00 UTC 2016
Activin signaling balances proliferation and differentiation of ovarian niche precursors and enables adjustment of niche numbers.
Development (Cambridge, England)
Lengil T,Gancz D,Gilboa L
A-11122 was used in Immunohistochemistry to suggest a novel model for how niche numbers and resident stem cells are corrected during development.
Sun Mar 01 00:00:00 UTC 2015
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Stem cell reports
Füllgrabe A,Joost S,Are A,Jacob T,Sivan U,Haegebarth A,Linnarsson S,Simons BD,Clevers H,Toftgård R,Kasper M
A-11122 was used in immunohistochemistry to study the stem cell pools in the hair follicle, sebaceous gland, and interfollicular epidermis of murine skin
Tue Nov 10 00:00:00 UTC 2015
Control of response reliability by parvalbumin-expressing interneurons in visual cortex.
Nature communications
Zhu Y,Qiao W,Liu K,Zhong H,Yao H
A-11122 was used in immunohistochemistry to report that parvalbumin interneurons are crucial for the formation of a reliable visual cortical representations of natural stimuli.
Tue Apr 14 00:00:00 UTC 2015
Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels.
The Journal of biological chemistry
Cesca F,Satapathy A,Ferrea E,Nieus T,Benfenati F,Scholz-Starke J
A-11122 was used in western blot to examine the effects of Kidins220 ablation on neuronal excitability.
Fri Jul 17 00:00:00 UTC 2015
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Molecular neurodegeneration
Lee IS,Jung K,Kim IS,Lee H,Kim M,Yun S,Hwang K,Shin JE,Park KI
A-11122 was used in immunohistochemistry to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology
Fri Aug 21 00:00:00 UTC 2015
Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep.
Scientific reports
Jeong K,Lee S,Seo H,Oh Y,Jang D,Choe J,Kim D,Lee JH,Jones WD
A-11122 was used in immunohistochemistry to study negative modulation of sleep by Ca-alpha1T, a fly T-type Ca2+ channel
Wed Dec 09 00:00:00 UTC 2015
Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.
Development (Cambridge, England)
Wang C,Guo X,Dou K,Chen H,Xi R
A-11122 was used in Immunohistochemistry to suggest that Ttk69 functions in parallel with Notch signaling and acts as a master repressor of EE cell specification in Drosophila ISC lineages primarily by suppressing AS-C genes.
Thu Oct 01 00:00:00 UTC 2015
A redox-sensitive yellow fluorescent protein sensor for monitoring nuclear glutathione redox dynamics.
Methods in molecular biology (Clifton, N.J.)
Banach-Latapy A,Dardalhon M,Huang ME
A-11122 was used in western blot to describe methods to measure the nuclear rxYFP redox state in human cells by a redox Western blot technique.
Thu Jun 11 00:00:00 UTC 2015
Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Miyoshi G,Young A,Petros T,Karayannis T,McKenzie Chang M,Lavado A,Iwano T,Nakajima M,Taniguchi H,Huang ZJ,Heintz N,Oliver G,Matsuzaki F,Machold RP,Fishell G
A-11122 was used in Immunohistochemistry to find that Prox1 function is differentially required during both embryonic and postnatal stages of development to direct the migration, differentiation, circuit integration, and maintenance programs within distinct subtypes of CGE-derived interneurons.
Wed Sep 16 00:00:00 UTC 2015
Mga is essential for the survival of pluripotent cells during peri-implantation development.
Development (Cambridge, England)
Washkowitz AJ,Schall C,Zhang K,Wurst W,Floss T,Mager J,Papaioannou VE
A-11122 was used in Immunohistochemistry to suggest a mechanism whereby Mga influences pluripotent cell survival through regulation of the polyamine pool in pluripotent cells of the embryo, whether they are in a proliferative or quiescent state.
Thu Jan 01 00:00:00 UTC 2015
Localization and Function of Pals1-associated Tight Junction Protein in Drosophila Is Regulated by Two Distinct Apical Complexes.
The Journal of biological chemistry
Sen A,Sun R,Krahn MP
A-11122 was used in immunohistochemistry - paraffin section to investigate Sdt and PATJ localization in the embryonic epidermis.
Fri May 22 00:00:00 UTC 2015
Targeted inhibition of the Shroom3-Rho kinase protein-protein interaction circumvents Nogo66 to promote axon outgrowth.
BMC neuroscience
Dickson HM,Wilbur A,Reinke AA,Young MA,Vojtek AB
A-11122 was used in immunocytochemistry to identify molecules that block the Shroom3-Rho kinase protein-protein interaction and modulate NogoA signaling.
Tue Jun 16 00:00:00 UTC 2015
A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.
Chemical senses
Kusumakshi S,Voigt A,Hübner S,Hermans-Borgmeyer I,Ortalli A,Pyrski M,Dörr J,Zufall F,Flockerzi V,Meyerhof W,Montmayeur JP,Boehm U
A-11122 was used in Immunohistochemistry to describe the TRPM5-IC mouse strain as a novel genetic tool and will facilitate the study and tissue-specific manipulation of TRPM5-expressing cells in vivo.
Wed Jul 01 00:00:00 UTC 2015
Tyramide Signal Amplification for Immunofluorescent Enhancement.
Methods in molecular biology (Clifton, N.J.)
Faget L,Hnasko TS
A-11122 was used in immunohistochemistry to assess immunofluorescent enhancement by tyramide signal amplification
Mon Apr 04 00:00:00 UTC 2016
Functional characterization of importin α8 as a classical nuclear localization signal receptor.
Biochimica et biophysica acta
Kimoto C,Moriyama T,Tsujii A,Igarashi Y,Obuse C,Miyamoto Y,Oka M,Yoneda Y
A-11122 was used in western blot to show that importin α8 transports SV40T antigen classical nuclear localization signal-containing cargo into the nucleus.
Thu Oct 01 00:00:00 UTC 2015
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.
Nature medicine
Cosgrove BD,Gilbert PM,Porpiglia E,Mourkioti F,Lee SP,Corbel SY,Llewellyn ME,Delp SL,Blau HM
A-11122 was used in immunohistochemistry to study effect of aging on the functionality of skeletal muscle stem cells.
Sat Mar 01 00:00:00 UTC 2014
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Nature
McCracken KW,Catá EM,Crawford CM,Sinagoga KL,Schumacher M,Rockich BE,Tsai YH,Mayhew CN,Spence JR,Zavros Y,Wells JM
A-11122 was used in Immunohistochemistry-immunofluorescence to generate, using human pluripotent stem cells, three-dimensional human gastric tissue in vitro for studying human stomach organogenesis and pathogenesis.
Thu Dec 18 00:00:00 UTC 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
A-11122 was used in immunohistochemistry (frozen) to investigate how heme regulates Spic in macrophages.
Thu Mar 13 00:00:00 UTC 2014
Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship.
Nature methods
Inagaki HK,Jung Y,Hoopfer ED,Wong AM,Mishra N,Lin JY,Tsien RY,Anderson DJ
A-11122 was used in immunohistochemistry to discuss a method to control of complex behavior in freely moving adult flies
Sat Mar 01 00:00:00 UTC 2014
Hydrogen peroxide primes heart regeneration with a derepression mechanism.
Cell research
Han P,Zhou XH,Chang N,Xiao CL,Yan S,Ren H,Yang XZ,Zhang ML,Wu Q,Tang B,Diao JP,Zhu X,Zhang C,Li CY,Cheng H,Xiong JW
A-11122 was used in immunohistochemistry - paraffin section and western blot to show that H2O2 acts via MAPK signaling for heart regeneration in adult zebrafish
Mon Sep 01 00:00:00 UTC 2014
Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
Nature immunology
Odendall C,Dixit E,Stavru F,Bierne H,Franz KM,Durbin AF,Boulant S,Gehrke L,Cossart P,Kagan JC
A-11122 was used in western blot to elucidate type I interferon-independent viral immune responses.
Fri Aug 01 00:00:00 UTC 2014
Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition.
Nature neuroscience
Szikra T,Trenholm S,Drinnenberg A,Jüttner J,Raics Z,Farrow K,Biel M,Awatramani G,Clark DA,Sahel JA,da Silveira RA,Roska B
A-11122 was used in immunohistochemistry to show that the retinal circuitry repurposes rods to relay cone-driven surround inhibition
Mon Dec 01 00:00:00 UTC 2014
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.
Nature neuroscience
Lodato S,Molyneaux BJ,Zuccaro E,Goff LA,Chen HH,Yuan W,Meleski A,Takahashi E,Mahony S,Rinn JL,Gifford DK,Arlotta P
A-11122 was used in immunohistochemistry to investigate the role of Fezf2 in the development of mouse corticospinal motor neurons
Fri Aug 01 00:00:00 UTC 2014
Celsr3 is required in motor neurons to steer their axons in the hindlimb.
Nature neuroscience
Chai G,Zhou L,Manto M,Helmbacher F,Clotman F,Goffinet AM,Tissir F
A-11122 was used in immunohistochemistry to investigate the regulation of Celsr3 in the peripheral nervous system
Mon Sep 01 00:00:00 UTC 2014
Short latency cerebellar modulation of the basal ganglia.
Nature neuroscience
Chen CH,Fremont R,Arteaga-Bracho EE,Khodakhah K
A-11122 was used in immunohistochemistry to investigate how the cerebellum and the basal ganglia regulate movement
Mon Dec 01 00:00:00 UTC 2014
ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.
Nature neuroscience
He Y,Zhang H,Yung A,Villeda SA,Jaeger PA,Olayiwola O,Fainberg N,Wyss-Coray T
A-11122 was used in immunohistochemistry and western blot to elucidate a major determinant of late-stage adult neurogenesis by ALK5-dependent TGF-beta signaling
Tue Jul 01 00:00:00 UTC 2014
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
Nature cell biology
Wang CC,Bajikar SS,Jamal L,Atkins KA,Janes KA
A-11122 was used in Western Blotting to identify two anticorrelated gene-expression programs that arise among single extracellular matrix (ECM)-attached cells during organotypic three-dimensional culture.
Tue Apr 01 00:00:00 UTC 2014
Coupling between endocytosis and sphingosine kinase 1 recruitment.
Nature cell biology
Shen H,Giordano F,Wu Y,Chan J,Zhu C,Milosevic I,Wu X,Yao K,Chen B,Baumgart T,Sieburth D,De Camilli P
A-11122 was used in immunocytochemistry to investigate the role of sphingosine phosphorylation in endocytic membrane trafficking
Tue Jul 01 00:00:00 UTC 2014
Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma.
Nature cell biology
Shin K,Lim A,Odegaard JI,Honeycutt JD,Kawano S,Hsieh MH,Beachy PA
A-11122 was used in immunohistochemistry - frozen section to show that muscle-invasive bladder carcinomas arise exclusively from Sonic hedgehog-expressing stem cells in basal urothelium
Thu May 01 00:00:00 UTC 2014
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
The Journal of clinical investigation
Li C,Ma H,Wang Y,Cao Z,Graves-Deal R,Powell AE,Starchenko A,Ayers GD,Washington MK,Kamath V,Desai K,Gerdes MJ,Solnica-Krezel L,Coffey RJ
A-11122 was used in Western Blot to observe coexpression of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, supporting a role for PLAC8 in cancer invasion in vivo.
Thu May 01 00:00:00 UTC 2014
Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.
Brain, behavior, and immunity
Buckman LB,Hasty AH,Flaherty DK,Buckman CT,Thompson MM,Matlock BK,Weller K,Ellacott KL
A-11122 was used in immunohistochemistry to test if obesity is associated with accumulation of peripheral immune cells into the central nervous system
Wed Jan 01 00:00:00 UTC 2014
Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency.
Acta neuropathologica
Ruparelia AA,Oorschot V,Vaz R,Ramm G,Bryson-Richardson RJ
A-11122 was used in immunohistochemistry to study the role of BAG3 in myofibrillar myopathy
Mon Dec 01 00:00:00 UTC 2014
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
Autophagy
Nicot AS,Lo Verso F,Ratti F,Pilot-Storck F,Streichenberger N,Sandri M,Schaeffer L,Goillot E
A-11122 was used in immunoprecipitation to report that NBR1 is a substrate of GSK3
Sun Jun 01 00:00:00 UTC 2014
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America
Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA
A-11122 was used in western blot to elucidate the noncanonical function of UNG
Tue Mar 18 00:00:00 UTC 2014
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Proceedings of the National Academy of Sciences of the United States of America
Ye X,Zeng H,Ning G,Reiter JF,Liu A
A-11122 was used in immunocytochemistry and western blot to determine the function of C2 calcium-dependent domain containing 3
Tue Feb 11 00:00:00 UTC 2014
Presynaptic gain control drives sweet and bitter taste integration in Drosophila.
Current biology : CB
Chu B,Chui V,Mann K,Gordon MD
A-11122 was used in immunohistochemistry to study the neural circuit mechanisms underlying the integration of sweet and bitter taste.
Mon Sep 08 00:00:00 UTC 2014
C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.
EMBO reports
Fossat N,Tourle K,Radziewic T,Barratt K,Liebhold D,Studdert JB,Power M,Jones V,Loebel DA,Tam PP
A-11122 was used in immunocytochemistry and immunoprecipitation to study the role of RNA-binding protein RBM47 in APOBEC1 editing.
Fri Aug 01 00:00:00 UTC 2014
Endogenous RNA interference is driven by copy number.
eLife
Cruz C,Houseley J
A-11122 was used in immunocytochemistry to demonstrate that low-level genome-wide pervasive transcription is sufficient to instigate RNAi.
Tue Feb 11 00:00:00 UTC 2014
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Mucosal immunology
Chan IH,Jain R,Tessmer MS,Gorman D,Mangadu R,Sathe M,Vives F,Moon C,Penaflor E,Turner S,Ayanoglu G,Chang C,Basham B,Mumm JB,Pierce RH,Yearley JH,McClanahan TK,Phillips JH,Cua DJ,Bowman EP,Kastelein RA,LaFace D
A-11122 was used in Immunohistochemistry to reveal an explicit role for IL-23-mediated initiation of gut tumorigenesis and implicate a key role for IL-23R(+) ILC3 in the absence of overt cellular infiltrate recruitment.
Tue Jul 01 00:00:00 UTC 2014
Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Koo JW,Lobo MK,Chaudhury D,Labonté B,Friedman A,Heller E,Peña CJ,Han MH,Nestler EJ
A-11122 was used in immunohistochemistry - free floating to study the contribution of GABAAR responses to morphine reward
Wed Oct 01 00:00:00 UTC 2014
Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye.
Neurobiology of disease
Cragnaz L,Klima R,Skoko N,Budini M,Feiguin F,Baralle FE
A-11122 was used in immunohistochemistry to assess the effects of TDP-43 inclusions in the Drosophila melanogaster eye.
Sat Nov 01 00:00:00 UTC 2014
Notch3 establishes brain vascular integrity by regulating pericyte number.
Development (Cambridge, England)
Wang Y,Pan L,Moens CB,Appel B
A-11122 was used in immunohistochemistry to study how pericyte development and density is regulated in the brain.
Wed Jan 01 00:00:00 UTC 2014
Drosophila intermediate neural progenitors produce lineage-dependent related series of diverse neurons.
Development (Cambridge, England)
Wang YC,Yang JS,Johnston R,Ren Q,Lee YJ,Luan H,Brody T,Odenwald WF,Lee T
A-11122 was used in immunohistochemistry to determine what neurons are derived from specific type II NB lineages.
Wed Jan 01 00:00:00 UTC 2014
Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish.
Development (Cambridge, England)
McGraw HF,Culbertson MD,Nechiporuk AV
A-11122 was used in immunohistochemistry to study the effect of Wnt signaling modulation in the posterior lateral line primordium
Fri Aug 01 00:00:00 UTC 2014
Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord.
Development (Cambridge, England)
Duval N,Daubas P,Bourcier de Carbon C,St Cloment C,Tinevez JY,Lopes M,Ribes V,Robert B
A-11122 was used in immunohistochemistry to determine the function of Msx genes in the spinal cord.
Tue Apr 01 00:00:00 UTC 2014
Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons.
Development (Cambridge, England)
Choi J,Park S,Sockanathan S
A-11122 was used in Immunohistochemistry-immunofluorescence to suggest that retinoic acid signalling pathways operate postmitotically to regulate radial migration and consolidate regional differences in cortical neuronal identity.
Sat Mar 01 00:00:00 UTC 2014
Lhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons.
Development (Cambridge, England)
Seredick S,Hutchinson SA,Van Ryswyk L,Talbot JC,Eisen JS
A-11122 was used in immunohistochemistry to investigate the roles of Lhx3 and its paralog Lhx4 in the development of motoneurons and ventral interneurons.
Wed Oct 01 00:00:00 UTC 2014
Ptch2 mediates the Shh response in Ptch1-/- cells.
Development (Cambridge, England)
Alfaro AC,Roberts B,Kwong L,Bijlsma MF,Roelink H
A-11122 was used in Immunohistochemistry to study the effect of Patched 2 on the sonic hedgehog response in Ptch1 -/-/ cells.
Mon Sep 01 00:00:00 UTC 2014
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Development (Cambridge, England)
Hatakeyama J,Wakamatsu Y,Nagafuchi A,Kageyama R,Shigemoto R,Shimamura K
A-11122 was used in immunohistochemistry (frozen) to study Notch signaling in the differentiation of neural progenitors.
Tue Apr 01 00:00:00 UTC 2014
Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Li L,Tian X,Zhu M,Bulgari D,Böhme MA,Goettfert F,Wichmann C,Sigrist SJ,Levitan ES,Wu C
A-11122 was used in immunocytochemistry to elucidate the molecular pathways downstream of Liprin-alpha in Drosophila brains.
Wed Jun 18 00:00:00 UTC 2014
Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hutchinson KM,Vonhoff F,Duch C
A-11122 was used in immunohistochemistry to show that Dscam1 has no role in adult Drosophila motoneuron dendrite spacing but is required for motoneuron dendritic growth.
Wed Jan 29 00:00:00 UTC 2014
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Verstegen AM,Tagliatti E,Lignani G,Marte A,Stolero T,Atias M,Corradi A,Valtorta F,Gitler D,Onofri F,Fassio A,Benfenati F
A-11122 was used in western blot to show that Cdk5 phosphorylation of SynI fine tunes the recruitment of synaptic vesicles to the active recycling pool and contributes to the Cdk5-mediated homeostatic responses.
Wed May 21 00:00:00 UTC 2014
Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kumar D,Freese M,Drexler D,Hermans-Borgmeyer I,Marquardt A,Boehm U
A-11122 was used in immunohistochemistry (frozen) to study the in utero communication between gonadotropin-releasing hormone neurons and arcuate nucleus kisspeptin neurons.
Wed Mar 05 00:00:00 UTC 2014
Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peng B,Xiao J,Wang K,So KF,Tipoe GL,Lin B
A-11122 was used in immunocytochemistry to study the role of microglia in photoreceptor degeneration in the rd10 mouse model of retinitis pigmentosa.
Wed Jun 11 00:00:00 UTC 2014
The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Marchetti G,Reichardt I,Knoblich JA,Besse F
A-11122 was used in immunohistochemistry to identify Brat as a mediator of axon maintenance in the Drosophila central nervous system.
Wed Oct 08 00:00:00 UTC 2014
Coxsackievirus A9 infects cells via nonacidic multivesicular bodies.
Journal of virology
Huttunen M,Waris M,Kajander R,Hyypiä T,Marjomäki V
A-11122 was used in immunocytochemistry to investigate the structures utilized by Coxsackievirus A9 for internalization and uncoating.
Thu May 01 00:00:00 UTC 2014
Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS).
International journal of pharmaceutics
Pettit MW,Dyer PD,Mitchell JC,Griffiths PC,Alexander B,Cattoz B,Heenan RK,King SM,Schweins R,Pullen F,Wicks SR,Richardson SC
A-11122 was used in western blot to describe the use of silica beads coated with myristic acid to enhance oral vaccine delivery to livestock.
Tue Jul 01 00:00:00 UTC 2014
A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium.
The American journal of pathology
Greaves E,Cousins FL,Murray A,Esnal-Zufiaurre A,Fassbender A,Horne AW,Saunders PT
A-11122 was used in immunohistochemistry (paraffin) to develop and validate a mouse model of endometriosis.
Tue Jul 01 00:00:00 UTC 2014
The reprogramming factor nuclear receptor subfamily 5, group A, member 2 cannot replace octamer-binding transcription factor 4 function in the self-renewal of embryonic stem cells.
The FEBS journal
Choi KW,Oh HR,Lee J,Lim B,Han YM,Oh J,Kim J
A-11122 was used in western blot to test if Nr5a2 functionally replaces Oct-4 in embryonic stem cells.
Sat Feb 01 00:00:00 UTC 2014
Radial glial progenitors repair the zebrafish spinal cord following transection.
Experimental neurology
Briona LK,Dorsky RI
A-11122 was used in immunohistochemistry - frozen section to investigate the role of Dbx1 in neurogenesis in zebrafish
Sun Jun 01 00:00:00 UTC 2014
SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development.
Journal of neurochemistry
Cheng J,Huang M,Zhu Y,Xin YJ,Zhao YK,Huang J,Yu JX,Zhou WH,Qiu Z
A-11122 was used in immunocytochemistry to describe the effect of SUMOlyation on methyl CpG binding protein 2 function.
Sat Mar 01 00:00:00 UTC 2014
The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting.
Laboratory investigation; a journal of technical methods and pathology
Lu ZH,Kaliberov S,Zhang J,Muz B,Azab AK,Sohn RE,Kaliberova L,Du Y,Curiel DT,Arbeit JM
A-11122 was used in immunohistochemistry to test the body-wide tropism of the Ad5-myeloid cell-binding peptide-expressing vector, its myeloid cell necessity, and vector-endothelial cell expression dose response.
Fri Aug 01 00:00:00 UTC 2014
Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.
Neuroscience bulletin
Hu Y,Li S,Jiang H,Li MT,Zhou JW
A-11122 was used in immunohistochemistry to investigate ephrin-B2/EphA4 signaling in cortical neuron migration.
Sun Jun 01 00:00:00 UTC 2014
High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy.
Journal of cell science
Loukil A,Zonca M,Rebouissou C,Baldin V,Coux O,Biard-Piechaczyk M,Blanchard JM,Peter M
A-11122 was used in immunoprecipitation to demonstrate that autophagy regulates cyclin A2 degradation.
Thu May 15 00:00:00 UTC 2014
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
Cell cycle (Georgetown, Tex.)
Zou J,Zhang D,Qin G,Chen X,Wang H,Zhang D
A-11122 was used in western blot to study the crosstalk between DNA damage response and the centrosome
Thu Sep 10 00:00:00 UTC 2015
Neural stem and progenitor cells in the aged subependyma are activated by the young niche.
Neurobiology of aging
Piccin D,Tufford A,Morshead CM
A-11122 was used in immunohistochemistry to study the number and proliferative capacity of neuronal stem cells in aging mice.
Tue Jul 01 00:00:00 UTC 2014
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
Human molecular genetics
Chua JP,Reddy SL,Merry DE,Adachi H,Katsuno M,Sobue G,Robins DM,Lieberman AP
A-11122 was used in immunohistochemistry (frozen) and western blot to elucidate the autophagic status in spinobulbar muscular atrophy using both cellular and mouse models.
Sat Mar 01 00:00:00 UTC 2014
Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophy.
Human molecular genetics
Lattanzi A,Salvagno C,Maderna C,Benedicenti F,Morena F,Kulik W,Naldini L,Montini E,Martino S,Gritti A
A-11122 was used in immunohistochemistry - free floating to use of a globoid cell leukodystrophy mouse model to show the therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy
Sun Jun 15 00:00:00 UTC 2014
Essential role of the chaperonin CCT in rod outer segment biogenesis.
Investigative ophthalmology & visual science
Sinha S,Belcastro M,Datta P,Seo S,Sokolov M
A-11122 was used in immunohistochemistry to study the biogenesis of rod outer segments and the indespensible role of chaperonin containing t-complex protein-1.
Thu May 22 00:00:00 UTC 2014
TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.
Cellular signalling
Sirianant L,Ousingsawat J,Tian Y,Schreiber R,Kunzelmann K
A-11122 was used in immunocytochemistry to study the effect of transmembrane channel-like proteins on Ca(2+) signaling.
Mon Dec 01 00:00:00 UTC 2014
Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.
Fish & shellfish immunology
Brietzke A,Goldammer T,Rebl H,Korytář T,Köllner B,Yang W,Rebl A,Seyfert HM
A-11122 was used in western blot to characterized the expression of IRAK4 in salmon, rainbow trout and maraena whitefish
Wed Jan 01 00:00:00 UTC 2014
Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans.
Genetics
James SW,Banta T,Barra J,Ciraku L,Coile C,Cuda Z,Day R,Dixit C,Eastlack S,Giang A,Goode J,Guice A,Huff Y,Humbert S,Kelliher C,Kobie J,Kohlbrenner E,Mwambutsa F,Orzechowski A,Shingler K,Spell C,Anglin SL
A-11122 was used in western blot to investigate the role of SR/RRM family proteins in cell cycle regulation
Wed Oct 01 00:00:00 UTC 2014
GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1.
Stem cells and development
Ahn J,Jang J,Choi J,Lee J,Oh SH,Lee J,Yoon K,Kim S
A-11122 was used in immunocytochemistry and immunohistochemistry to study the role of GSK3alpha and GSK3beta in neuronal differentiation.
Thu May 15 00:00:00 UTC 2014
Bone marrow stromal cells enhance the osteogenic properties of hydroxyapatite scaffolds by modulating the foreign body reaction.
Journal of tissue engineering and regenerative medicine
Tour G,Wendel M,Tcacencu I
A-11122 was used in immunocytochemistry and immunohistochemistry - paraffin section to study the osteogenic properties of bone marrow stromal cell-loaded biomimetic constructs and assess the cellular components elicited.
Sat Nov 01 00:00:00 UTC 2014
Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation.
Pigment cell & melanoma research
Sarode B,Nowell CS,Ihm J,Kostic C,Arsenijevic Y,Moulin AP,Schorderet DF,Beermann F,Radtke F
A-11122 was used in immunohistochemistry - paraffin section to determine the role of Notch signaling in the development of the anterior pigmented epithelium.
Tue Jul 01 00:00:00 UTC 2014
CDK-dependent phosphorylation of Alp7-Alp14 (TACC-TOG) promotes its nuclear accumulation and spindle microtubule assembly.
Molecular biology of the cell
Okada N,Toda T,Yamamoto M,Sato M
A-11122 was used in immunoprecipitation to show that CDK regulates spindle assembly at mitotic entry by regulating Alp7-Alp14 complex phosphorylation.
Tue Jul 01 00:00:00 UTC 2014
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.
Molecular biology of the cell
Galagovsky D,Katz MJ,Acevedo JM,Sorianello E,Glavic A,Wappner P
A-11122 was used in immunohistochemistry to determine how the modulation of the PI3K pathway in a cell-autonomous manner restricts growth through the Drosophila insulin-degrading enzyme
Sat Mar 01 00:00:00 UTC 2014
Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.
Frontiers in human neuroscience
Slimak MA,Ables JL,Frahm S,Antolin-Fontes B,Santos-Torres J,Moretti M,Gotti C,Ibañez-Tallon I
A-11122 was used in immunohistochemistry to assess the contribution of allelic variants of beta4 to nicotine receptor activity in the medial habenula.
Thu Jan 30 00:00:00 UTC 2014
Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character.
Developmental biology
Fish MB,Nakayama T,Fisher M,Hirsch N,Cox A,Reeder R,Carruthers S,Hall A,Stemple DL,Grainger RM
A-11122 was used in immunohistochemistry to characterize a Xenopus tropicalis rax mutant.
Sat Nov 15 00:00:00 UTC 2014
Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development.
Developmental biology
Huang W,Wang G,Delaspre F,Vitery Mdel C,Beer RL,Parsons MJ
A-11122 was used in immunocytochemistry to describe a model of beta-cell neogenesis using the 2° islets in the pancreatic tail of the larval zebrafish.
Wed Oct 01 00:00:00 UTC 2014
Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation.
Developmental biology
Wu CY,Hooper RM,Han K,Taneyhill LA
A-11122 was used in immunohistochemistry - frozen section to test if αN-catenin contributes to neural crest cell migration and formation of the cranial ganglia.
Fri Aug 15 00:00:00 UTC 2014
Systematic comparison of adeno-associated virus and biotinylated dextran amine reveals equivalent sensitivity between tracers and novel projection targets in the mouse brain.
The Journal of comparative neurology
Wang Q,Henry AM,Harris JA,Oh SW,Joines KM,Nyhus J,Hirokawa KE,Dee N,Mortrud M,Parry S,Ouellette B,Caldejon S,Bernard A,Jones AR,Zeng H,Hohmann JG
A-11122 was used in immunohistochemistry to compare adeno-associated virus and biotinylated dextran amine for their effectiveness as an anterograde neuronal tracer.
Sun Jun 15 00:00:00 UTC 2014
Birthdating of myenteric neuron subtypes in the small intestine of the mouse.
The Journal of comparative neurology
Bergner AJ,Stamp LA,Gonsalvez DG,Allison MB,Olson DP,Myers MG,Anderson CR,Young HM
A-11122 was used in immunohistochemistry to determine when murine small intestine myenteric neuron subtypes are born.
Sat Feb 15 00:00:00 UTC 2014
AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations.
Journal of neuroscience methods
Alves JN,Muir EM,Andrews MR,Ward A,Michelmore N,Dasgupta D,Verhaagen J,Moloney EB,Keynes RJ,Fawcett JW,Rogers JH
A-11122 was used in immunohistochemistry - frozen section to characterize the expression of chondroitinase ABC delivery by an adenovirus vector to the central nervous system.
Wed Apr 30 00:00:00 UTC 2014
Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins.
Biology open
Stickel S,Su TT
A-11122 was used in immunohistochemistry to study the tissue specific effects of oncogenes.
Sat Mar 15 00:00:00 UTC 2014
Correlation of the same fields imaged in the TEM, confocal, LM, and microCT by image registration: from specimen preparation to displaying a final composite image.
Methods in cell biology
Keene DR,Tufa SF,Wong MH,Smith NR,Sakai LY,Horton WA
A-11122 was used in immunohistochemistry to describe a method to align images manually.
Mon Jun 08 00:00:00 UTC 2015
Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons.
Neuroreport
Ishikawa M,Shiota J,Ishibashi Y,Hakamata T,Shoji S,Fukuchi M,Tsuda M,Shirao T,Sekino Y,Baraban JM,Tabuchi A
A-11122 was used in immunocytochemistry to test if different MKL1 isoforms differ in their subcellular localization, transcriptional activity, and effect on dendritic number and axonal length
Wed May 28 00:00:00 UTC 2014
Germline and somatic vitelline proteins colocalize in aggregates in the follicular epithelium of Drosophila ovaries.
Fly
Furriols M,Casanova J
A-11122 was used in immunohistochemistry to study Nasrat and Polehole during development.
Mon Sep 28 00:00:00 UTC 2015
A genetic screen for functional partners of condensin in fission yeast.
G3 (Bethesda, Md.)
Robellet X,Fauque L,Legros P,Mollereau E,Janczarski S,Parrinello H,Desvignes JP,Thevenin M,Bernard P
A-11122 was used in ChIP assay to investigate factors that associate with condensin in Schizosaccharomyces pombe
Wed Feb 19 00:00:00 UTC 2014
Multicilin drives centriole biogenesis via E2f proteins.
Genes & development
Ma L,Quigley I,Omran H,Kintner C
A-11122 was used in ChIP assay to show that this complex is disabled by mutations in human Multicilin that cause a severe congenital mucociliary clearance disorder due to reduced generation of multiple cilia.
Tue Jul 01 00:00:00 UTC 2014
Multicilin drives centriole biogenesis via E2f proteins.
Genes & development
Ma L,Quigley I,Omran H,Kintner C
A-11122 was used in ChIP assay to show that this complex is disabled by mutations in human Multicilin that cause a severe congenital mucociliary clearance disorder due to reduced generation of multiple cilia.
Tue Jul 01 00:00:00 UTC 2014
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.
Cell death & disease
Charan RA,Johnson BN,Zaganelli S,Nardozzi JD,LaVoie MJ
A-11122 was used in immunoprecipitation to explore the parkin-dependent regulation of apoptosis and the turnover of damaged mitochondria in various cell types.
Thu Jul 03 00:00:00 UTC 2014
Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes.
Cardiovascular research
Bingen BO,Engels MC,Schalij MJ,Jangsangthong W,Neshati Z,Feola I,Ypey DL,Askar SF,Panfilov AV,Pijnappels DA,de Vries AA
A-11122 was used in Western Blot to provide proof-of-concept for shockless defibrillation.
Wed Oct 01 00:00:00 UTC 2014
Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.
Nature communications
Bassett AR,Azzam G,Wheatley L,Tibbit C,Rajakumar T,McGowan S,Stanger N,Ewels PA,Taylor S,Ponting CP,Liu JL,Sauka-Spengler T,Fulga TA
A-11122 was used in immunohistochemistry to describe methods to block specific miRNA-MRE interactions at any point during development.
Tue Aug 19 00:00:00 UTC 2014
A mesoscale connectome of the mouse brain.
Nature
Oh SW,Harris JA,Ng L,Winslow B,Cain N,Mihalas S,Wang Q,Lau C,Kuan L,Henry AM,Mortrud MT,Ouellette B,Nguyen TN,Sorensen SA,Slaughterbeck CR,Wakeman W,Li Y,Feng D,Ho A,Nicholas E,Hirokawa KE,Bohn P,Joines KM,Peng H,Hawrylycz MJ,Phillips JW,Hohmann JG,Wohnoutka P,Gerfen CR,Koch C,Bernard A,Dang C,Jones AR,Zeng H
A-11122 was used in Immunohistochemistry to report a brain-wide, cellular-level, mesoscale connectome for the mouse.
Thu Apr 10 00:00:00 UTC 2014
Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.
Development (Cambridge, England)
Ip CK,Fossat N,Jones V,Lamonerie T,Tam PP
A-11122 was used in Immunocytochemistry to show that OTX2 can interact with the H1 regulatory region of Dkk1 to activate its expression.
Wed Oct 01 00:00:00 UTC 2014
p53 prevents neurodegeneration by regulating synaptic genes.
Proceedings of the National Academy of Sciences of the United States of America
Merlo P,Frost B,Peng S,Yang YJ,Park PJ,Feany M
A-11122 was used in Immunohistochemistry to demonstrate that the control of synaptic genes by p53 is conserved in mammals.
Tue Dec 16 00:00:00 UTC 2014
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
PLoS genetics
Thomas RE,Andrews LA,Burman JL,Lin WY,Pallanck LJ
A-11122 was used in immunohistochemistry to investigate how PINK1 is degraded.
Mon Dec 15 00:00:00 UTC 2014
Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis.
Nature communications
Hou X,Zhou J,Liu C,Liu L,Shen L,Yu H
A-11122 was used in Chromatin immunoprecipitation to report the discovery of an Arabidopsis NF-Y complex that exerts epigenetic control over flowering time by integrating environmental and developmental signals.
Fri Aug 08 00:00:00 UTC 2014
MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells.
Biochimica et biophysica acta
Jafferali MH,Vijayaraghavan B,Figueroa RA,Crafoord E,Gudise S,Larsson VJ,Hallberg E
A-11122 was used in immunocytochemistry to describe a method to investigate protein interactions in the nuclear envelope.
Wed Oct 01 00:00:00 UTC 2014
Interaction of human laminin receptor with Sup35, the [PSI⁺] prion-forming protein from S. cerevisiae: a yeast model for studies of LamR interactions with amyloidogenic proteins.
PloS one
Pampeno C,Derkatch IL,Meruelo D
A-11122 was used in immunocytochemistry, immunoprecipitation, and western blot to examine if LamR interacts with prions and amyloids.
Mon Sep 08 00:00:00 UTC 2014
Axolotls with an under- or oversupply of neural crest can regulate the sizes of their dorsal root ganglia to normal levels.
Developmental biology
Zarzosa A,Grassme K,Tanaka E,Taniguchi Y,Bramke S,Kurth T,Epperlein H
A-11122 was used in Immunohistochemistry to show that size compensation of DRG in axolotl occurs in 2 cm juveniles after undersupply of NC (up-regulation) and in 5 cm juveniles after oversupply of NC (down-regulation).
Wed Oct 01 00:00:00 UTC 2014
Cigarette smoke exposure during pregnancy alters fetomaternal cell trafficking leading to retention of microchimeric cells in the maternal lung.
PloS one
Vogelgesang A,Scapin C,Barone C,Tam E,Blumental Perry A,Dammann CE
A-11122 was used in immunohistochemistry to test if mild chronic diffuse smoke injury attracts fetal cells to maternal lungs.
Thu Jan 22 00:00:00 UTC 2015
Conditional genetic transsynaptic tracing in the embryonic mouse brain.
Journal of visualized experiments : JoVE
Kumar D,Boehm U
A-11122 was used in immunohistochemistry to describe a method for transsynaptic tracing in mouse embryos using the novel recombinant ROSA26 alleles.
Mon Dec 22 00:00:00 UTC 2014
Wiring the retinal circuits activated by light during early development.
Neural development
Bertolesi GE,Hehr CL,McFarlane S
A-11122 was used in immunohistochemistry to determine the developmental time at which cells that participate in image-forming and non-image-forming tasks come on-line in the retina
Thu Feb 13 00:00:00 UTC 2014
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells.
Neural development
Oliva C,Choi CM,Nicolai LJ,Mora N,De Geest N,Hassan BA
A-11122 was used in immunohistochemistry to discuss the composition of the optic lobe in Drosophila.
Wed Feb 26 00:00:00 UTC 2014
Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control.
PloS one
Robbins RM,Gbur SC,Beitel GJ
A-11122 was used in immunohistochemistry to find new non-apoptotic roles for Yki, DIAP1 and Ice in epithelial tube size regulation
Mon Mar 30 00:00:00 UTC 2015
Early netrin-1 expression impairs central nervous system remyelination.
Annals of neurology
Tepavčević V,Kerninon C,Aigrot MS,Meppiel E,Mozafari S,Arnould-Laurent R,Ravassard P,Kennedy TE,Nait-Oumesmar B,Lubetzki C
A-11122 was used in Immunohistochemistry-immunofluorescence to support the conclusion that netrin-1 expression within demyelinating MS plaques blocks OPC recruitment, which with repeated demyelinating episodes contributes to permanent remyelination failure.
Fri Aug 01 00:00:00 UTC 2014
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Science (New York, N.Y.)
Voss FK,Ullrich F,Münch J,Lazarow K,Lutter D,Mah N,Andrade-Navarro MA,von Kries JP,Stauber T,Jentsch TJ
A-11122 was used in Immunocytochemistry-immunofluorescence to show that VRAC defines a class of anion channels, suggests that VRAC is identical to the volume-sensitive organic osmolyte/anion channel VSOAC, and explains the heterogeneity of native VRAC currents.
Fri May 09 00:00:00 UTC 2014
Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates.
Human molecular genetics
Appocher C,Klima R,Feiguin F
A-11122 was used in Immunohistochemistry to identify a new function for the REEP1 protein in vivo and a novel cellular mechanism to prevent Tau toxicity.
Sat Dec 20 00:00:00 UTC 2014
Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring.
Translational psychiatry
Uchida T,Furukawa T,Iwata S,Yanagawa Y,Fukuda A
A-11122 was used in immunohistochemistry to study the relationship between maternal stress and the gamma-aminobutyric acid synthesizing enzyme glutamate decarboxylase 67.
Tue Mar 11 00:00:00 UTC 2014
Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.
Nature communications
Maléth J,Choi S,Muallem S,Ahuja M
A-11122 was used in western blot to determine STIM1 conformation and Orai1 gating by translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion
Wed Dec 17 00:00:00 UTC 2014
A genetically specified connectomics approach applied to long-range feeding regulatory circuits.
Nature neuroscience
Atasoy D,Betley JN,Li WP,Su HH,Sertel SM,Scheffer LK,Simpson JH,Fetter RD,Sternson SM
A-11122 was used in Immunohistochemistry to demonstrate that GESEM labeling enables long-range connectomics with molecularly defined cell types.
Mon Dec 01 00:00:00 UTC 2014
Whole mount immunolabeling of olfactory receptor neurons in the Drosophila antenna.
Journal of visualized experiments : JoVE
Karim MR,Endo K,Moore AW,Taniguchi H
A-11122 was used in immunohistochemistry to describe a whole mount immunological labeling method to assay in vivo olfactory receptor neurons.
Sun May 04 00:00:00 UTC 2014
Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
The Journal of biological chemistry
Qadota H,Luo Y,Matsunaga Y,Park AS,Gernert KM,Benian GM
A-11122 was used in immunohistochemistry to study PAT-4 binding to UNC-112.
Fri May 16 00:00:00 UTC 2014
Transcriptional control of GABAergic neuronal subtype identity in the thalamus.
Neural development
Sellers K,Zyka V,Lumsden AG,Delogu A
A-11122 was used in immunohistochemistry to study differentiation of thalamic GABA neurons.
Sun Jun 15 00:00:00 UTC 2014
Dual innervation of neonatal Merkel cells in mouse touch domes.
PloS one
Niu J,Vysochan A,Luo W
A-11122 was used in immunohistochemistry - frozen section to investigate the role of TrkA in the development of Ret+ and TrkC+ fibers
Tue Jan 13 00:00:00 UTC 2015
A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb.
Nature communications
Tatti R,Bhaukaurally K,Gschwend O,Seal RP,Edwards RH,Rodriguez I,Carleton A
A-11122 was used in immunohistochemistry to analyze glomerular glutamatergic neurons and their control of sensory information transfer in the mouse olfactory bulb
Wed May 07 00:00:00 UTC 2014
Distinct fibroblast lineages determine dermal architecture in skin development and repair.
Nature
Driskell RR,Lichtenberger BM,Hoste E,Kretzschmar K,Simons BD,Charalambous M,Ferron SR,Herault Y,Pavlovic G,Ferguson-Smith AC,Watt FM
A-11122 was used in flow cytometry to determine the origin of fibroblasts in skin connective tissue
Thu Dec 12 00:00:00 UTC 2013
Genetic identification of a neural circuit that suppresses appetite.
Nature
Carter ME,Soden ME,Zweifel LS,Palmiter RD
A-11122 was used in immunohistochemistry to identify and characterize neurons in the parabrachial nucleus that regulate feeding
Thu Nov 07 00:00:00 UTC 2013
Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.
Nature
Vrontou S,Wong AM,Rau KK,Koerber HR,Anderson DJ
A-11122 was used in immunohistochemistry to report that MRGPRB4(+) neurons are activated by massage-like stroking of hairy skin
Thu Jan 31 00:00:00 UTC 2013
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.
Nature methods
Ranzani M,Cesana D,Bartholomae CC,Sanvito F,Pala M,Benedicenti F,Gallina P,Sergi LS,Merella S,Bulfone A,Doglioni C,von Kalle C,Kim YJ,Schmidt M,Tonon G,Naldini L,Montini E
A-11122 was used in immunohistochemistry - frozen section to use LVV-based insertional mutagenesis to identify liver cancer-associated genes.
Fri Feb 01 00:00:00 UTC 2013
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Cell host & microbe
Guichard A,Cruz-Moreno B,Aguilar B,van Sorge NM,Kuang J,Kurkciyan AA,Wang Z,Hang S,Pineton de Chambrun GP,McCole DF,Watnick P,Nizet V,Bier E
A-11122 was used in immunocytochemistry to study how Rab inhibits the barrier-disrupting effects of CtxA.
Wed Sep 11 00:00:00 UTC 2013
Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits.
Nature neuroscience
Zembrzycki A,Chou SJ,Ashery-Padan R,Stoykova A,O'Leary DD
A-11122 was used in immunohistochemistry - frozen section to demonstrate that S size determined the resolution and completeness of body maps.
Thu Aug 01 00:00:00 UTC 2013
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.
Blood
Lee SC,Phipson B,Hyland CD,Leong HS,Allan RS,Lun A,Hilton DJ,Nutt SL,Blewitt ME,Smyth GK,Alexander WS,Majewski IJ
A-11122 was used in western blot to study the role of polycomb repressive complex 2 in leukemia progression
Thu Oct 10 00:00:00 UTC 2013
BR signal influences Arabidopsis ovule and seed number through regulating related genes expression by BZR1.
Molecular plant
Huang HY,Jiang WB,Hu YW,Wu P,Zhu JY,Liang WQ,Wang ZY,Lin WH
A-11122 was used in ChIP assay to report that the brassinosteroid signal is involved in ovule initiation and development.
Fri Mar 01 00:00:00 UTC 2013
IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.
The Journal of allergy and clinical immunology
Barlow JL,Peel S,Fox J,Panova V,Hardman CS,Camelo A,Bucks C,Wu X,Kane CM,Neill DR,Flynn RJ,Sayers I,Hall IP,McKenzie AN
A-11122 was used in immunohistochemistry to discuss IL-25 and IL-33 in the context of asthma.
Tue Oct 01 00:00:00 UTC 2013
PINK1 is degraded through the N-end rule pathway.
Autophagy
Yamano K,Youle RJ
A-11122 was used in western blot to elucidate how PINK1 tags damaged mitochondria for autophagic elimination.
Fri Nov 01 00:00:00 UTC 2013
Electrophysiological integration and action potential properties of transplanted cardiomyocytes derived from induced pluripotent stem cells.
Cardiovascular research
Halbach M,Peinkofer G,Baumgartner S,Maass M,Wiedey M,Neef K,Krausgrill B,Ladage D,Fatima A,Saric T,Hescheler J,Müller-Ehmsen J
A-11122 was used in immunohistochemistry to assess the long-term electrophysiological integration and maturation of transplanted induced pluripotent stem cell-derived cardiomyocytes.
Sun Dec 01 00:00:00 UTC 2013
Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia.
Leukemia
Noguera NI,Song MS,Divona M,Catalano G,Calvo KL,García F,Ottone T,Florenzano F,Faraoni I,Battistini L,Colombo E,Amadori S,Pandolfi PP,Lo-Coco F
A-11122 was used in immunocytochemistry to elucidate the role of NPM-HAUSP in controlling PTEN deubiquitination and trafficking.
Mon Apr 01 00:00:00 UTC 2013
Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Peng YC,Levine CM,Zahid S,Wilson EL,Joyner AL
A-11122 was used in Immunohistochemistry on frozen tissues to study the replenishment of distinct stromal subtypes during regeneration by sonic hedgehog signalling to multiple prostate stromal stem cells.
Tue Dec 17 00:00:00 UTC 2013
Effect of intravenous coadministration of human stroma cell lines on engraftment of long-term repopulating clonal myelodysplastic syndrome cells in immunodeficient mice.
Blood cancer journal
Li X,Marcondes AM,Ragoczy T,Telling A,Deeg HJ
A-11122 was used in immunohistochemistry to describe improvements for a xenotransplantation model to study myelodysplastic syndrome
Fri Apr 26 00:00:00 UTC 2013
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Farrell MS,Pei Y,Wan Y,Yadav PN,Daigle TL,Urban DJ,Lee HM,Sciaky N,Simmons A,Nonneman RJ,Huang XP,Hufeisen SJ,Guettier JM,Moy SS,Wess J,Caron MG,Calakos N,Roth BL
A-11122 was used in immunohistochemistry to characterize a mouse where Gs DREADD is selectively expressed in striatopallidal medium spiny neurons.
Mon Apr 01 00:00:00 UTC 2013
CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.
The Journal of cell biology
Shahbazi MN,Megias D,Epifano C,Akhmanova A,Gundersen GG,Fuchs E,Perez-Moreno M
A-11122 was used in immunocytochemistry to study the interaction between p120-catenin and CLASP2 that governs microtubule dynamics at adherens junctions
Mon Dec 23 00:00:00 UTC 2013
Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.
The Journal of cell biology
Nakaya Y,Sukowati EW,Sheng G
A-11122 was used in immunohistochemistry to study how integrity of epiblasts requires dystroglycan-mediated mictrotubule anchoring to the basal cortex and CLASP
Mon Aug 19 00:00:00 UTC 2013
Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin-mediated anchorage to vimentin filaments.
Glia
Walko G,Wögenstein KL,Winter L,Fischer I,Feltri ML,Wiche G
A-11122 was used in immunoprecipitation to study plectin in myelinating Schwann cells.
Thu Aug 01 00:00:00 UTC 2013
Mn tolerance in rice is mediated by MTP8.1, a member of the cation diffusion facilitator family.
Journal of experimental botany
Chen Z,Fujii Y,Yamaji N,Masuda S,Takemoto Y,Kamiya T,Yusuyin Y,Iwasaki K,Kato S,Maeshima M,Ma JF,Ueno D
A-11122 was used in immunohistochemistry to study manganese tolerance in the rice plant (Oryza sativa L.).
Fri Nov 01 00:00:00 UTC 2013
Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells.
Development (Cambridge, England)
Sotillos S,Krahn M,Espinosa-Vázquez JM,Hombría JC
A-11122 was used in western blot to report that Baz-STAT92E interaction depends on the presence of the Drosophila Src kinases to regulate cell polarity.
Mon Apr 01 00:00:00 UTC 2013
ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.
Development (Cambridge, England)
Herder C,Swiercz JM,Müller C,Peravali R,Quiring R,Offermanns S,Wittbrodt J,Loosli F
A-11122 was used in immunohistochemistry to show that RhoA signaling controls of neuroepithelial apicobasal polarity during vertebrate development.
Mon Jul 01 00:00:00 UTC 2013
Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits.
Development (Cambridge, England)
O'Donnell MP,Bashaw GJ
A-11122 was used in immunohistochemistry to elucidate the role of Abl in regulating motor axon pathfinding.
Mon Jul 01 00:00:00 UTC 2013
Learning-related translocation of δ-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bertran-Gonzalez J,Laurent V,Chieng BC,Christie MJ,Balleine BW
A-11122 was used in immunohistochemistry to investigate the involvement of theta-opioid receptors in learning and the cognitive control of action.
Wed Oct 09 00:00:00 UTC 2013
Notum homolog plays a novel role in primary motor innervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cantu JA,Flowers GP,Topczewski J
A-11122 was used in immunohistochemistry to study the role of Notum homolog in primary motor innervation.
Wed Jan 30 00:00:00 UTC 2013
TrkB signaling directs the incorporation of newly generated periglomerular cells in the adult olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bergami M,Vignoli B,Motori E,Pifferi S,Zuccaro E,Menini A,Canossa M
A-11122 was used in immunohistochemistry to understand the role of TrkB in the integration of new periglomerular cells in the adult olfactory bulb.
Wed Jul 10 00:00:00 UTC 2013
Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ramaker JM,Swanson TL,Copenhaver PF
A-11122 was used in Immunohistochemistry to show that endogenously expressed amyloid precursor family of proteins colocalise with Goα in both insect and mammalian nervous systems, including human brain.
Wed Jun 12 00:00:00 UTC 2013
Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Petrova R,Garcia AD,Joyner AL
A-11122 was used in immunohistochemistry to study the relationship between GLI3 repressor activity and sonic hedgehog signaling and its role in multiple adult neural stem cell and astrocyte functions
Wed Oct 30 00:00:00 UTC 2013
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Marker DF,Tremblay MÈ,Puccini JM,Barbieri J,Gantz Marker MA,Loweth CJ,Muly EC,Lu SM,Goodfellow VS,Dewhurst S,Gelbard HA
A-11122 was used in immunocytochemistry to characterize a mixed-lineage kinase 3 inhibitor , named URMC-099.
Wed Jun 12 00:00:00 UTC 2013
A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Megill A,Lee T,DiBattista AM,Song JM,Spitzer MH,Rubinshtein M,Habib LK,Capule CC,Mayer M,Turner RS,Kirkwood A,Yang J,Pak DT,Lee HK,Hoe HS
A-11122 was used in immunocytochemistry to study the effect of a novel amyloid-binding small molecule on Ras-mediated spinogenesis.
Wed May 29 00:00:00 UTC 2013
Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.
Frontiers in molecular neuroscience
Lignani G,Ferrea E,Difato F,Amarù J,Ferroni E,Lugarà E,Espinoza S,Gainetdinov RR,Baldelli P,Benfenati F
A-11122 was used in immunocytochemistry to develop a system to study the network response to defined long-term experimental protocols.
Fri Aug 23 00:00:00 UTC 2013
Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization.
Traffic (Copenhagen, Denmark)
David JP,Andersen MN,Olesen SP,Rasmussen HB,Schmitt N
A-11122 was used in immunocytochemistry to investigate IKs trafficking.
Mon Apr 01 00:00:00 UTC 2013
REV, A BRET-Based Sensor of ERK Activity.
Frontiers in endocrinology
Xu C,Peter M,Bouquier N,Ollendorff V,Villamil I,Liu J,Fagni L,Perroy J
A-11122 was used in immunocytochemistry to developed a bioluminescence resonance energy transfer (BRET)-based biosensor of ERK activity.
Mon Aug 05 00:00:00 UTC 2013
Enhanced insulin clearance in mice lacking TRPM8 channels.
American journal of physiology. Endocrinology and metabolism
McCoy DD,Zhou L,Nguyen AK,Watts AG,Donovan CM,McKemy DD
A-11122 was used in immunohistochemistry to study the role of TRPM8 channels in insulin regulation.
Mon Jul 01 00:00:00 UTC 2013
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Katter K,Geurts AM,Hoffmann O,Mátés L,Landa V,Hiripi L,Moreno C,Lazar J,Bashir S,Zidek V,Popova E,Jerchow B,Becker K,Devaraj A,Walter I,Grzybowksi M,Corbett M,Filho AR,Hodges MR,Bader M,Ivics Z,Jacob HJ,Pravenec M,Bosze Z,Rülicke T,Izsvák Z
A-11122 was used in immunohistochemistry - frozen section to study the use of the Sleeping beauty transposon for germline transgenesis in mice, rats, and rabbits.
Fri Mar 01 00:00:00 UTC 2013
Bullous pemphigoid IgG induces BP180 internalization via a macropinocytic pathway.
The American journal of pathology
Hiroyasu S,Ozawa T,Kobayashi H,Ishii M,Aoyama Y,Kitajima Y,Hashimoto T,Jones JC,Tsuruta D
A-11122 was used in western blot to investigate the effect of bullous pemphigoid IgG on BP180 internalization.
Fri Mar 01 00:00:00 UTC 2013
The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities.
Journal of neurochemistry
Kao CY,Hsu YC,Liu JW,Lee DC,Chung YF,Chiu IM
A-11122 was used in immunocytochemistry to.
Mon Jul 01 00:00:00 UTC 2013
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.
Human molecular genetics
Lignani G,Raimondi A,Ferrea E,Rocchi A,Paonessa F,Cesca F,Orlando M,Tkatch T,Valtorta F,Cossette P,Baldelli P,Benfenati F
A-11122 was used in immunocytochemistry, immunoprecipitation, and western blot to elucidate the mechanisms of epileptogenesis that are linked to SYN1 mutations
Sat Jun 01 00:00:00 UTC 2013
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
International immunology
Miller CN,Hartigan-O'Connor DJ,Lee MS,Laidlaw G,Cornelissen IP,Matloubian M,Coughlin SR,McDonald DM,McCune JM
A-11122 was used in immunohistochemistry to study murine lymphatic cell IL-7 production and its role in lymphocyte homeostasis
Thu Aug 01 00:00:00 UTC 2013
Molecular diversity of early-born subplate neurons.
Cerebral cortex (New York, N.Y. : 1991)
Hoerder-Suabedissen A,Molnár Z
A-11122 was used in immunohistochemistry - free floating to study the expression of the presynaptic protein complexin 3, connective tissue growth factor, the orphan nuclear receptor Nr4a2, and the G-protein-coupled lysophosphatidic acid receptor in subplate cells.
Sat Jun 01 00:00:00 UTC 2013
Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles.
Human gene therapy
Löw K,Aebischer P,Schneider BL
A-11122 was used in immunohistochemistry to evaluate the transduction efficacy of nigral neurons with adeno-associated viral vectors
Sat Jun 01 00:00:00 UTC 2013
Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron.
Cell calcium
Jeon JP,Roh SE,Wie J,Kim J,Kim H,Lee KP,Yang D,Jeon JH,Cho NH,Kim IG,Kang DE,Kim HJ,So I
A-11122 was used in immunoprecipitation to demonstrate that TRPC4/TRPC5 is activated by Gαi.
Tue Oct 01 00:00:00 UTC 2013
Streptococcus pneumoniae requires iron for its viability and expresses two membrane proteins that bind haemoglobin and haem.
Metallomics : integrated biometal science
Romero-Espejel ME,González-López MA,Olivares-Trejo Jde J
A-11122 was used in western blot to study iron acquisition by Streptococcus pneumoniae.
Mon Apr 01 00:00:00 UTC 2013
Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans.
Genetics
Grossman EN,Giurumescu CA,Chisholm AD
A-11122 was used in western blot to assess the genetic and cellular requirements for Eph signaling in a Caenorhabditis elegans axon guidance choice point.
Fri Nov 01 00:00:00 UTC 2013
Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord.
Gene therapy
Peluffo H,Foster E,Ahmed SG,Lago N,Hutson TH,Moon L,Yip P,Wanisch K,Caraballo-Miralles V,Olmos G,Lladó J,McMahon SB,Yáñez-Muñoz RJ
A-11122 was used in immunohistochemistry to evaluate integration-deficient lentiviral vectors for gene transfer in the spinal cord.
Sat Jun 01 00:00:00 UTC 2013
Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.
Biology of reproduction
Defalco T,Saraswathula A,Briot A,Iruela-Arispe ML,Capel B
A-11122 was used in immunohistochemistry to show the mechanism for the effect of testosterone on mouse fetal Leydig cell progenitors.
Mon Apr 01 00:00:00 UTC 2013
Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice.
Brain structure & function
Chapman RJ,Lall VK,Maxeiner S,Willecke K,Deuchars J,King AE
A-11122 was used in immunohistochemistry to identify Cx45-positive neurones in the adult spinal dorsal horn.
Wed May 01 00:00:00 UTC 2013
Putative excitatory and putative inhibitory inputs are localised in different dendritic domains in a Drosophila flight motoneuron.
The European journal of neuroscience
Kuehn C,Duch C
A-11122 was used in immunocytochemistry to estimate the location of the spike-initiating zone and the dendritic distribution patterns of putative synaptic inputs on a single flight motorneuron.
Fri Mar 01 00:00:00 UTC 2013
The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.
Molecular biology of the cell
Bower R,Tritschler D,Vanderwaal K,Perrone CA,Mueller J,Fox L,Sale WS,Porter ME
A-11122 was used in immunoprecipitation to identify a conserved region in DRC4 critical for assembly of the nexin-dynein regulatory complex into the axoneme
Mon Apr 01 00:00:00 UTC 2013
Intrapancreatic ganglia neurons receive projection fibers from melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve of the mouse.
Brain research
Tsumori T,Oka T,Yokota S,Niu JG,Yasui Y
A-11122 was used in immunohistochemistry to discover a pathway from MC4R-expressing neurons in the dorsal motor nucleus of the vagus nerve to the intrapancreatic ganglia.
Wed Nov 06 00:00:00 UTC 2013
Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.
Biochemical and biophysical research communications
Sohn YI,Lee NJ,Chung A,Saavedra JM,Scott Turner R,Pak DT,Hoe HS
A-11122 was used in immunohistochemistry to elucidate the molecular mechanism by which Valsartan regulates cognitive function.
Fri Oct 04 00:00:00 UTC 2013
HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation.
Placenta
Liu X,Gu W,Li X
A-11122 was used in western blot to show that HLA-G regulates JEG-3 cell invasion by influencing STAT3 activation.
Fri Nov 01 00:00:00 UTC 2013
Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.
Developmental biology
Yang Y,Wang H,Zhang J,Luo F,Herrup K,Bibb JA,Lu R,Miller RH
A-11122 was used in immunocytochemistry and immunohistochemistry to study the role of cyclin dependent kinase 5 in oligodendrocyte development and myelin formation.
Sat Jun 15 00:00:00 UTC 2013
The Drosophila putative histone acetyltransferase Enok maintains female germline stem cells through regulating Bruno and the niche.
Developmental biology
Xin T,Xuan T,Tan J,Li M,Zhao G,Li M
A-11122 was used in immunohistochemistry to study the role of epigenetic regulation of cell fate using Drosophila ovarian germline stem cells.
Sun Dec 01 00:00:00 UTC 2013
Development of myenteric cholinergic neurons in ChAT-Cre;R26R-YFP mice.
The Journal of comparative neurology
Hao MM,Bornstein JC,Young HM
A-11122 was used in immunohistochemistry to.
Tue Oct 01 00:00:00 UTC 2013
Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain.
The Journal of comparative neurology
Lindberg D,Chen P,Li C
A-11122 was used in immunohistochemistry to elucidate how ventromedial hypothalamus neurons exercise output functions and describe an anatomical link between these neurons and the sympathetic nervous system.
Tue Oct 01 00:00:00 UTC 2013
Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord.
The Journal of comparative neurology
Mandadi S,Hong P,Tran MA,Bráz JM,Colarusso P,Basbaum AI,Whelan PJ
A-11122 was used in immunohistochemistry to assess the extent and role of collaterals of capsaicin-sensitive nociceptive sacrocaudal afferent nerves.
Thu Aug 15 00:00:00 UTC 2013
Diverse neuronal lineages make stereotyped contributions to the Drosophila locomotor control center, the central complex.
The Journal of comparative neurology
Yang JS,Awasaki T,Yu HH,He Y,Ding P,Kao JC,Lee T
A-11122 was used in immunohistochemistry to examine the development and anatomy of the insect locomotor control center.
Thu Aug 15 00:00:00 UTC 2013
Dynamics of olfactory and hippocampal neurogenesis in adult sheep.
The Journal of comparative neurology
Brus M,Meurisse M,Gheusi G,Keller M,Lledo PM,Lévy F
A-11122 was used in immunohistochemistry to investigate the olfactory and hippocampal neurogenesis in adult sheep.
Tue Jan 01 00:00:00 UTC 2013
The interfascicular trigeminal nucleus: a precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping.
The Journal of comparative neurology
Fu Y,Tvrdik P,Makki N,Machold R,Paxinos G,Watson C
A-11122 was used in immunohistochemistry to study neurons of the interfascicular trigeminal nucleus.
Fri Feb 15 00:00:00 UTC 2013
Role of EphA/ephrin--a signaling in the development of topographic maps in mouse corticothalamic projections.
The Journal of comparative neurology
Torii M,Rakic P,Levitt P
A-11122 was used in immunohistochemistry to assess the role of EphA7 on each step of corticothalamic growth.
Fri Feb 15 00:00:00 UTC 2013
Long-lasting single-neuron labeling by in vivo electroporation without microscopic guidance.
Journal of neuroscience methods
Oyama K,Ohara S,Sato S,Karube F,Fujiyama F,Isomura Y,Mushiake H,Iijima T,Tsutsui K
A-11122 was used in immunohistochemistry to develop a method to record and label single neurons.
Sun Sep 15 00:00:00 UTC 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
A-11122 was used in western blot to develop a method using in utero electroporation to introduce pathogenic genes into the brain of mice to study amyotrophic lateral sclerosis.
Sun Dec 01 00:00:00 UTC 2013
Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.
Experimental physiology
Hogh KL,Uy CE,Asadi A,Baker RK,Riedel MJ,Gray SL
A-11122 was used in immunohistochemistry - paraffin section and western blot to study the effect of pancreatic-beta cell overexpression of PPARalpha on glucose-tolerance in a murine model of diet-induced obesity.
Fri Feb 01 00:00:00 UTC 2013
Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation.
Genesis (New York, N.Y. : 2000)
Burtscher I,Barkey W,Lickert H
A-11122 was used in immunohistochemistry to investigate Foxa2 function during organ development and homeostasis.
Thu Aug 01 00:00:00 UTC 2013
Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro.
Neuroreport
Shibata K,Nakahara S,Shimizu E,Yamashita T,Matsuki N,Koyama R
A-11122 was used in immunohistochemistry to investigate the role of repulsive guidance molecule a in hippocampal mossy fiber branching in vitro.
Wed Aug 07 00:00:00 UTC 2013
Developmental regulation of nucleolus size during Drosophila eye differentiation.
PloS one
Baker NE
A-11122 was used in immunohistochemistry to assess nucleolar size in the Drosophila eye imaginal disc.
Tue Dec 03 00:00:00 UTC 2013
Heat shock modulates neutrophil motility in zebrafish.
PloS one
Lam PY,Harvie EA,Huttenlocher A
A-11122 was used in immunoprecipitation to study the effect of short-term heat shock treatment on neutrophil function using zebrafish.
Mon Oct 13 00:00:00 UTC 2014
Baicalin maintains late-stage functional cardiomyocytes in embryoid bodies derived from murine embryonic stem cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Tang M,Yin M,Tang M,Liang H,Yu C,Hu X,Luo H,Baudis B,Haustein M,Khalil M,Sarić T,Hescheler J,Xi J
A-11122 was used in immunocytochemistry to study the effect of baicalin on the in vitro cardiac differentiation of murine embryonic stem cells.
Tue Mar 18 00:00:00 UTC 2014
Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress.
Biochimica et biophysica acta
Johnson MA,Sharma M,Mok MT,Henderson BR
A-11122 was used in western blot to examine the impact of cell cycle progression and DNA replication stress on actin nuclear localization in live cells.
Tue Oct 01 00:00:00 UTC 2013
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis.
Nature communications
Hosaka K,Yang Y,Seki T,Nakamura M,Andersson P,Rouhi P,Yang X,Jensen L,Lim S,Feng N,Xue Y,Li X,Larsson O,Ohhashi T,Cao Y
A-11122 was used in flow cytometry to investigate the effects of anti-platelet-derived growth factor drugs on cancerous vascular remodeling.
Thu Jan 30 00:00:00 UTC 2014
Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.
PloS one
Vandewalle J,Langen M,Zschätzsch M,Nijhof B,Kramer JM,Brems H,Bauters M,Lauwers E,Srahna M,Marynen P,Verstreken P,Schenck A,Hassan BA,Froyen G
A-11122 was used in immunohistochemistry to study the role of HUWE expression on the developing nervous system.
Wed Oct 01 00:00:00 UTC 2014
Arabidopsis MSI1 connects LHP1 to PRC2 complexes.
The EMBO journal
Derkacheva M,Steinbach Y,Wildhaber T,Mozgová I,Mahrez W,Nanni P,Bischof S,Gruissem W,Hennig L
A-11122 was used in ChIP assay to find that MSI1 serves to link PRC2 to LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), a protein that binds H3K27me3 in vitro and in vivo and is required for a functional plant PcG system.
Wed Jul 17 00:00:00 UTC 2013
Fluorescent mRNA labeling through cytoplasmic FISH.
Nature protocols
Gasnier M,Dennis C,Vaurs-Barrière C,Chazaud C
A-11122 was used in Immunohistochemistry-immunofluorescence to determine presence of target cytoplasmic RNA via fluorescence ISH (cFISH).
Sun Dec 01 00:00:00 UTC 2013
Impaired sterol ester synthesis alters the response of Arabidopsis thaliana to Phytophthora infestans.
The Plant journal : for cell and molecular biology
Kopischke M,Westphal L,Schneeberger K,Clark R,Ossowski S,Wewer V,Fuchs R,Landtag J,Hause G,Dörmann P,Lipka V,Weigel D,Schulze-Lefert P,Scheel D,Rosahl S
A-11122 was used in Western Blot to suggest a role for sterol conjugates in cell non-autonomous defense responses against invasive filamentous pathogens.
Fri Feb 01 00:00:00 UTC 2013
FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain.
PloS one
Brackett DM,Qing F,Amieux PS,Sellers DL,Horner PJ,Morris DR
A-11122 was used in immunohistochemistry to measure FMRP isoforms in the brain.
Fri Sep 06 00:00:00 UTC 2013
JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes.
PLoS genetics
Drerup CM,Nechiporuk AV
A-11122 was used in immunohistochemistry to identify JNK-interacting protein 3 as a mediator of dynein-based retrograde transport of activated c-Jun N-terminal Kinase and lysosomes
Thu Jun 13 00:00:00 UTC 2013
The Gcm/Glide molecular and cellular pathway: new actors and new lineages.
Developmental biology
Laneve P,Delaporte C,Trebuchet G,Komonyi O,Flici H,Popkova A,D'Agostino G,Taglini F,Kerekes I,Giangrande A
A-11122 was used in Western Blot to understand the Gcm/Glide biology.
Fri Mar 01 00:00:00 UTC 2013
A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord.
PloS one
Del Barrio MG,Bourane S,Grossmann K,Schüle R,Britsch S,O'Leary DD,Goulding M
A-11122 was used in immunohistochemistry - frozen section to describe a combinatorial transcription factor code that defines nine different inhibitory and excitatory interneuron populations in laminae III-IV of the postnatal cord.
Wed Aug 20 00:00:00 UTC 2014
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
The Journal of biological chemistry
Pohar J,Pirher N,Benčina M,Manček-Keber M,Jerala R
A-11122 was used in western blot to investigate the regulatory effect of UNC93B on nucleic acid-sensing Toll-like receptors.
Fri Jan 04 00:00:00 UTC 2013
Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice.
PloS one
Lu ZH,Kaliberov S,Sohn RE,Kaliberova L,Curiel DT,Arbeit JM
A-11122 was used in immunohistochemistry to study adenoviral vectors that target tumor vascular endothelial cells.
Mon Mar 02 00:00:00 UTC 2015
A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons.
PLoS genetics
Ghosh A,Kling T,Snaidero N,Sampaio JL,Shevchenko A,Gras H,Geurten B,Göpfert MC,Schulz JB,Voigt A,Simons M
A-11122 was used in immunohistochemistry to identify a key role for ceramide phosphoethanolamine in wrapping of axons by glia
Wed Aug 20 00:00:00 UTC 2014
Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation.
PloS one
Fei D,Krimm RF
A-11122 was used in immunohistochemistry to study the composition of taste neurons in terms of TrkB-receptor.
Tue Sep 16 00:00:00 UTC 2014
Autophagy drives epidermal deterioration in a Drosophila model of tissue aging.
Aging
Scherfer C,Han VC,Wang Y,Anderson AE,Galko MJ
A-11122 was used in immunohistochemistry to examine the crosstalk between longevity programs and specific tissues during aging
Mon Apr 01 00:00:00 UTC 2013
Axon position within the corpus callosum determines contralateral cortical projection.
Proceedings of the National Academy of Sciences of the United States of America
Zhou J,Wen Y,She L,Sui YN,Liu L,Richards LJ,Poo MM
A-11122 was used in Immunohistochemistry to find that axonal position within the CC plays a critical role in this projection.
Tue Jul 16 00:00:00 UTC 2013
The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila.
PloS one
Müller R,Jenny A,Stanley P
A-11122 was used in immunohistochemistry - paraffin section to characterize eogt knock-down.
Tue Dec 24 00:00:00 UTC 2013
FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.
Journal of molecular cell biology
Neguembor MV,Xynos A,Onorati MC,Caccia R,Bortolanza S,Godio C,Pistoni M,Corona DF,Schotta G,Gabellini D
A-11122 was used in Immunoprecipitation to show that, when over-expressed, facioscapulohumeral muscular dystrophy region gene 1 binds and interferes with the activity of the histone methyltransferase Suv4-20h1 both in mammals and Drosophila.
Tue Oct 01 00:00:00 UTC 2013
Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools.
PloS one
Kramer S,Bannerman-Chukualim B,Ellis L,Boulden EA,Kelly S,Field MC,Carrington M
A-11122 was used in immunocytochemistry to characterize trypanosome PABP1 and PABP2
Wed Sep 04 00:00:00 UTC 2013
Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.
PloS one
Absood A,Gandomani B,Zaki A,Nasta V,Michail A,Habib PM,Hodish I
A-11122 was used in western blot to test if insulin therapy improves β-cell function by alleviating ER-crowding.
Fri Sep 06 00:00:00 UTC 2013
HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
PloS one
Stoll SJ,Bartsch S,Kroll J
A-11122 was used in immunohistochemistry to assess the role of HOXC9 in lymphatic vessel development
Tue Sep 03 00:00:00 UTC 2013
Conservation of the extended substrate specificity profiles among homologous granzymes across species.
Molecular & cellular proteomics : MCP
Plasman K,Maurer-Stroh S,Ahmad J,Hao H,Kaiserman D,Sirota FL,Jonckheere V,Bird PI,Gevaert K,Van Damme P
A-11122 was used in immunocytochemistry to characterize human granzyme H and mouse granzyme C.
Tue Oct 01 00:00:00 UTC 2013
Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro.
Nature protocols
Qian L,Berry EC,Fu JD,Ieda M,Srivastava D
A-11122 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to describe a detailed step-by-step protocol for in vitro cardiac reprogramming using retroviruses encoding GMT.
Sat Jun 01 00:00:00 UTC 2013
Mapping of MN1 sequences necessary for myeloid transformation.
PloS one
Kandilci A,Surtel J,Janke L,Neale G,Terranova S,Grosveld GC
A-11122 was used in flow cytometry to identify the sequences within MN1 that induced leukemia.
Tue Nov 26 00:00:00 UTC 2013
The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Miao S,Chen R,Ye J,Tan GH,Li S,Zhang J,Jiang YH,Xiong ZQ
A-11122 was used in Immunohistochemistry to report that the Angelman syndrome (AS) protein ubiquitin-protein ligase E3A (Ube3a) plays an important role in specifying the polarization of pyramidal neuron dendritic arbors in mice.
Wed Jan 02 00:00:00 UTC 2013
Exposure to DNA is insufficient for in vitro transgenesis of live bovine sperm and embryos.
Reproduction (Cambridge, England)
Eghbalsaied S,Ghaedi K,Laible G,Hosseini SM,Forouzanfar M,Hajian M,Oback F,Nasr-Esfahani MH,Oback B
A-11122 was used in Immunocytochemistry to find no evidence of intracellular plasmid uptake and none of the resulting zygotes (n=96) and blastocysts were GFP positive by fluorescence microscopy or genomic PCR (n=751).
Tue Jan 01 00:00:00 UTC 2013
Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.
Genome biology
Zuleger N,Boyle S,Kelly DA,de las Heras JI,Lazou V,Korfali N,Batrakou DG,Randles KN,Morris GE,Harrison DJ,Bickmore WA,Schirmer EC
A-11122 was used in western blot to screen and identify proteins involved in relocating chromosomes to the nuclear periphery
Fri Feb 15 00:00:00 UTC 2013
Co-translational processing of glycoprotein 3 from equine arteritis virus: N-glycosylation adjacent to the signal peptide prevents cleavage.
The Journal of biological chemistry
Matczuk AK,Kunec D,Veit M
A-11122 was used in immunoprecipitation to study the processing of glycoprotein 3 of equine arteritis virus.
Fri Dec 06 00:00:00 UTC 2013
Three-dimensional tracking and analysis of ion channel signals across dendritic arbors.
Frontiers in neural circuits
Ginger M,Broser P,Frick A
A-11122 was used in immunocytochemistry to report a method to map and quantify the expression of specific ion channel types across the entire dendritic arbor
Mon May 19 00:00:00 UTC 2014
Etoposide induces nuclear re-localisation of AID.
PloS one
Lambert LJ,Walker S,Feltham J,Lee HJ,Reik W,Houseley J
A-11122 was used in immunocytochemistry to test if epigenetic reprogramming uses a pathway that instigates prolonged nuclear residence of AID in B cells.
Thu Sep 11 00:00:00 UTC 2014
Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.
Stem cells translational medicine
Stacpoole SR,Webber DJ,Bilican B,Compston A,Chandran S,Franklin RJ
A-11122 was used in Immunohistochemistry to propose that careful consideration of physiological oxygen environments, and particularly changes in oxygen tension, has relevance for the practical approaches to cellular therapies.
Sat Jun 01 00:00:00 UTC 2013
Expression of sall4 in taste buds of zebrafish.
Developmental neurobiology
Jackson R,Braubach OR,Bilkey J,Zhang J,Akimenko MA,Fine A,Croll RP,Jonz MG
A-11122 was used in Immunohistochemistry to reveal sall4 expression in chemosensory cells and implicate this transcription factor in the development and renewal of taste epithelia in zebrafish.
Mon Jul 01 00:00:00 UTC 2013
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
Cell
Luo W,Sehgal A
A-11122 was used in immunohistochemistry to report that miR-279 modulates the JAK/STAT pathway to drive rest:activity rhythms in Drosophila.
Fri Feb 17 00:00:00 UTC 2012
The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.
Cell research
Sandri C,Caccavari F,Valdembri D,Camillo C,Veltel S,Santambrogio M,Lanzetti L,Bussolino F,Ivaska J,Serini G
A-11122 was used in immunocytochemistry to identify RIN2 as a key effector that interacts with and mediates the pro-adhesive and -angiogenic activity of R-Ras
Mon Oct 01 00:00:00 UTC 2012
Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.
Nature neuroscience
Boulin T,Rapti G,Briseño-Roa L,Stigloher C,Richmond JE,Paoletti P,Bessereau JL
A-11122 was used in western blot to identify MOLO- at the Caenorhabditis elegans neuromuscular junction.
Mon Oct 01 00:00:00 UTC 2012
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.
Nature cell biology
Galic M,Jeong S,Tsai FC,Joubert LM,Wu YI,Hahn KM,Cui Y,Meyer T
A-11122 was used in immunocytochemistry to investigate how N-BAR proteins are recruited to the cell membrane.
Wed Aug 01 00:00:00 UTC 2012
Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.
Nature cell biology
Nelson KS,Khan Z,Molnár I,Mihály J,Kaschube M,Beitel GJ
A-11122 was used in immunohistochemistry to study how intestinal tube dimensions are regulated.
Sun Mar 25 00:00:00 UTC 2012
Multipotent and unipotent progenitors contribute to prostate postnatal development.
Nature cell biology
Ousset M,Van Keymeulen A,Bouvencourt G,Sharma N,Achouri Y,Simons BD,Blanpain C
A-11122 was used in immunohistochemistry - frozen section to study the cellular hierarchy that governs prostate postnatal development.
Thu Nov 01 00:00:00 UTC 2012
NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors.
The Journal of clinical investigation
Hawk JD,Bookout AL,Poplawski SG,Bridi M,Rao AJ,Sulewski ME,Kroener BT,Manglesdorf DJ,Abel T
A-11122 was used in Immunohistochemistry to demonstrate that the Nr4a gene family contributes to memory formation and is a promising target for improving cognitive function.
Mon Oct 01 00:00:00 UTC 2012
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.
Kidney international
Perisic L,Lal M,Hulkko J,Hultenby K,Önfelt B,Sun Y,Dunér F,Patrakka J,Betsholtz C,Uhlen M,Brismar H,Tryggvason K,Wernerson A,Pikkarainen T
A-11122 was used in immunocytochemistry to study the localization and function of pleckstrin homology domain-containing, family H (with MyTH4 domain), member 2 (Plekhh2).
Thu Nov 01 00:00:00 UTC 2012
Hub GABA neurons mediate gamma-frequency oscillations at ictal-like event onset in the immature hippocampus.
Neuron
Quilichini PP,Le Van Quyen M,Ivanov A,Turner DA,Carabalona A,Gozlan H,Esclapez M,Bernard C
A-11122 was used in immunohistochemistry to investigate gamma-frequency oscillations.
Thu Apr 12 00:00:00 UTC 2012
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.
Neuron
Akil O,Seal RP,Burke K,Wang C,Alemi A,During M,Edwards RH,Lustig LR
A-11122 was used in immunocytochemistry to report successful restoration of hearing by VGLUT3 gene replacement in mice.
Thu Jul 26 00:00:00 UTC 2012
Structural basis for heteromeric assembly and perinuclear organization of keratin filaments.
Nature structural & molecular biology
Lee CH,Kim MS,Chung BM,Leahy DJ,Coulombe PA
A-11122 was used in western blot to report the crystal structure of interacting 2B regions from the central coiled-coil domains of keratins 5 and 4.
Sun Jun 17 00:00:00 UTC 2012
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
Developmental cell
Matthews HK,Delabre U,Rohn JL,Guck J,Kunda P,Baum B
A-11122 was used in immunocytochemistry to identify Ect2 as a central regulator of mitotic rounding
Tue Aug 14 00:00:00 UTC 2012
Barriers to male transmission of mitochondrial DNA in sperm development.
Developmental cell
DeLuca SZ,O'Farrell PH
A-11122 was used in immunohistochemistry to examine how mitochondrial DNA is eliminated during spermatogenesis.
Tue Mar 13 00:00:00 UTC 2012
Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study.
Cardiovascular research
Naik V,Leaf EM,Hu JH,Yang HY,Nguyen NB,Giachelli CM,Speer MY
A-11122 was used in immunohistochemistry - paraffin section to identify the precursors of cartilaginous and bony elements in atherosclerotic vessels.
Fri Jun 01 00:00:00 UTC 2012
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Proceedings of the National Academy of Sciences of the United States of America
Dahlgaard K,Jung A,Qvortrup K,Clausen H,Kjaerulff O,Wandall HH
A-11122 was used in immunohistochemistry to report that loss of Egh causes overgrowth of peripheral nerves and attraction of immune cells to the nerves.
Tue May 01 00:00:00 UTC 2012
Timing of intra-arterial neural stem cell transplantation after hypoxia-ischemia influences cell engraftment, survival, and differentiation.
Stroke
Rosenblum S,Wang N,Smith TN,Pendharkar AV,Chua JY,Birk H,Guzman R
A-11122 was used in immunocytochemistry and immunohistochemistry to examine the effect of timing of neuronal stem cell transplantation on cell engraftment, survival, and differentiation.
Fri Jun 01 00:00:00 UTC 2012
Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme.
The Journal of cell biology
Sarkar AA,Zohn IE
A-11122 was used in immunocytochemistry to elucidate the molecular cause of the abnormal behavior of Hectd1 mutant cranial mesenchyme
Mon Mar 19 00:00:00 UTC 2012
Elongator complex is critical for cell cycle progression and leaf patterning in Arabidopsis.
The Plant journal : for cell and molecular biology
Xu D,Huang W,Li Y,Wang H,Huang H,Cui X
A-11122 was used in Chromatin immunoprecipitation to demonstrate that the Arabidopsis Elongator complex is essential regulator of cell cycle and in promoting leaf polarity.
Thu Mar 01 00:00:00 UTC 2012
Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila.
Development (Cambridge, England)
Ng J
A-11122 was used in immunohistochemistry to investigate branching morphology in axons and dendrites.
Sun Jan 01 00:00:00 UTC 2012
Identification of a novel developmental mechanism in the generation of mesothelia.
Development (Cambridge, England)
Winters NI,Thomason RT,Bader DM
A-11122 was used in immunohistochemistry to study the fate of mesothelial progenitor cells.
Wed Aug 01 00:00:00 UTC 2012
The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors.
Development (Cambridge, England)
Acharya A,Baek ST,Huang G,Eskiocak B,Goetsch S,Sung CY,Banfi S,Sauer MF,Olsen GS,Duffield JS,Olson EN,Tallquist MD
A-11122 was used in immunohistochemistry to report a role for Tcf2 (epicardin/Pod/capsulin) in cardiac fibroblast lineage specification.
Fri Jun 01 00:00:00 UTC 2012
Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program.
Development (Cambridge, England)
Stam FJ,Hendricks TJ,Zhang J,Geiman EJ,Francius C,Labosky PA,Clotman F,Goulding M
A-11122 was used in immunohistochemistry - frozen section to describe a transcriptional program that controls Renshaw cell differentiation.
Sun Jan 01 00:00:00 UTC 2012
Migration of cardiomyocytes is essential for heart regeneration in zebrafish.
Development (Cambridge, England)
Itou J,Oishi I,Kawakami H,Glass TJ,Richter J,Johnson A,Lund TC,Kawakami Y
A-11122 was used in immunohistochemistry to show that cardiomyocyte migration to the injury site is essential for heart regeneration.
Thu Nov 01 00:00:00 UTC 2012
Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Development (Cambridge, England)
Morita H,Kajiura-Kobayashi H,Takagi C,Yamamoto TS,Nonaka S,Ueno N
A-11122 was used in western blot to study the cellular and molecular mechanisms underlying the role of non-neural ectoderm in Xenopus complete neural tube closure.
Sun Apr 01 00:00:00 UTC 2012
Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bundschuh ST,Zhu P,Schärer YP,Friedrich RW
A-11122 was used in immunohistochemistry (frozen) to examine the role of dopamine in odor processing.
Wed May 16 00:00:00 UTC 2012
PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gómez-Varela D,Schmidt M,Schoellerman J,Peters EC,Berg DK
A-11122 was used in western blot to study the mechanism by which plasma membrane calcium-ATPase pump isoform 2 controls calcium signaling in neurons.
Wed May 16 00:00:00 UTC 2012
Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shimada IS,LeComte MD,Granger JC,Quinlan NJ,Spees JL
A-11122 was used in immunohistochemistry to study the self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated after stroke.
Wed Jun 06 00:00:00 UTC 2012
Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Satou C,Kimura Y,Higashijima S
A-11122 was used in immunohistochemistry to study diversity of zebrafish V0 neurons.
Wed Feb 01 00:00:00 UTC 2012
Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tanokashira D,Morita T,Hayashi K,Mayanagi T,Fukumoto K,Kubota Y,Yamashita T,Sobue K
A-11122 was used in immunocytochemistry to study the role of reduced caldesmon expression in the mechanism by which glucocorticoids inhibit dendritic spine development.
Wed Oct 17 00:00:00 UTC 2012
α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mackey ED,Engle SE,Kim MR,O'Neill HC,Wageman CR,Patzlaff NE,Wang Y,Grady SR,McIntosh JM,Marks MJ,Lester HA,Drenan RM
A-11122 was used in immunocytochemistry and immunohistochemistry to determine the regional and subcellular expression pattern of α6-containing nAChRs.
Wed Jul 25 00:00:00 UTC 2012
Increasing doublecortin expression promotes migration of human embryonic stem cell-derived neurons.
Stem cells (Dayton, Ohio)
Filipovic R,Santhosh Kumar S,Fiondella C,Loturco J
A-11122 was used in immunocytochemistry to test the effect of doublecortin modulation on the proliferation and migration of human neuronal progenitors.
Sat Sep 01 00:00:00 UTC 2012
Mob1: defining cell polarity for proper cell division.
Journal of cell science
Tavares A,Gonçalves J,Florindo C,Tavares AA,Soares H
A-11122 was used in immunocytochemistry to elucidate the role of Tetrahymena Mob.
Sun Jan 15 00:00:00 UTC 2012
The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.
Journal of cell science
Coutinho-Budd J,Ghukasyan V,Zylka MJ,Polleux F
A-11122 was used in immunocytochemistry, immunoprecipitation, and western blot to elucidate the role of F-BAR-domains in cell morphogenesis.
Sun Jul 15 00:00:00 UTC 2012
Dissociated neuronal culture expressing ionotropic odorant receptors as a hybrid odorant biosensor--proof-of-concept study.
The Analyst
Tanada N,Sakurai T,Mitsuno H,Bakkum DJ,Kanzaki R,Takahashi H
A-11122 was used in immunocytochemistry to report a proof-of-concept study of a hybrid odorant biosensor.
Tue Aug 07 00:00:00 UTC 2012
Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology
Polyak S,Mach A,Porvasnik S,Dixon L,Conlon T,Erger KE,Acosta A,Wright AJ,Campbell-Thompson M,Zolotukhin I,Wasserfall C,Mah C
A-11122 was used in immunohistochemistry to identify adeno-associated virus pseudotypes for transduction of the small intestine and colonic epithelium.
Wed Feb 01 00:00:00 UTC 2012
ARAD proteins associated with pectic Arabinan biosynthesis form complexes when transiently overexpressed in planta.
Planta
Harholt J,Jensen JK,Verhertbruggen Y,Søgaard C,Bernard S,Nafisi M,Poulsen CP,Geshi N,Sakuragi Y,Driouich A,Knox JP,Scheller HV
A-11122 was used in western blot to elucidate enzymes involved in the biosynthesis of pectin.
Sun Jul 01 00:00:00 UTC 2012
Autologous bone marrow cell infusions suppress tumor initiation in hepatocarcinogenic mice with liver cirrhosis.
Journal of gastroenterology and hepatology
Maeda M,Takami T,Terai S,Sakaida I
A-11122 was used in immunohistochemistry - paraffin section to assess the effects of autologous bone marrow cell infusion on hepatocarcinogenesis.
Thu Mar 01 00:00:00 UTC 2012
Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA.
Plant molecular biology
Ding D,Muthuswamy S,Meier I
A-11122 was used in western blot to propose that NUA scaffolds AtMAD and AtMAD2 at the nuclear pore to form a functional complex in the Arabidopsis root meristem.
Fri Jun 01 00:00:00 UTC 2012
The Lewis GFP transgenic rat strain is a useful cell donor for neural transplantation.
Cell transplantation
Krause M,Ganser C,Kobayashi E,Papazoglou A,Nikkhah G
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the potential of green fluorescent protein-transgenic Lewis rats to serve as donor tissue for neural stem cell transplantation.
Fri Dec 06 00:00:00 UTC 2013
The Lewis GFP transgenic rat strain is a useful cell donor for neural transplantation.
Cell transplantation
Krause M,Ganser C,Kobayashi E,Papazoglou A,Nikkhah G
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate the potential of green fluorescent protein-transgenic Lewis rats to serve as donor tissue for neural stem cell transplantation.
Fri Dec 06 00:00:00 UTC 2013
Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene.
Molecular and cellular biochemistry
Solberg N,Machon O,Krauss S
A-11122 was used in immunohistochemistry to clone and characterize the 5'-flanking promoter region of the mouse Tcf3 gene.
Sun Jan 01 00:00:00 UTC 2012
In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation.
Biochemical and biophysical research communications
Lim SY,Lee DG,Sivakumaran P,Crombie D,Slavin J,Dottori M,Conley B,Denham M,Leung J,Tee R,Dusting GJ,Pebay A,Dilley RJ
A-11122 was used in immunohistochemistry - paraffin section to assess the use of in vivo vascularized tissue engineered chambers.
Fri May 25 00:00:00 UTC 2012
Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channel.
Journal of biochemistry
Kiyonaka S,Nakajima H,Takada Y,Hida Y,Yoshioka T,Hagiwara A,Kitajima I,Mori Y,Ohtsuka T
A-11122 was used in western blot to elucidate how CAST/ERC2 regulates the calcium-dependent release of neurotransmitters.
Wed Aug 01 00:00:00 UTC 2012
Coordinate development of skin cells and cutaneous sensory axons in zebrafish.
The Journal of comparative neurology
O'Brien GS,Rieger S,Wang F,Smolen GA,Gonzalez RE,Buchanan J,Sagasti A
A-11122 was used in immunohistochemistry to analyze cutaneous innervation in the head, trunk, and tail of zebrafish embryos and larvae.
Thu Mar 01 00:00:00 UTC 2012
Comprehensive timeline of mesodermal development in the quail small intestine.
Developmental dynamics : an official publication of the American Association of Anatomists
Thomason RT,Bader DM,Winters NI
A-11122 was used in immunohistochemistry to investigate the development of the intestinal mesoderm.
Thu Nov 01 00:00:00 UTC 2012
olig2-Expressing hindbrain cells are required for migrating facial motor neurons.
Developmental dynamics : an official publication of the American Association of Anatomists
Zannino DA,Sagerström CG,Appel B
A-11122 was used in immunohistochemistry to show that olig2 function contributes to the migration of facial motor neurons.
Wed Feb 01 00:00:00 UTC 2012
Life-long preservation of the regenerative capacity in the fin and heart in zebrafish.
Biology open
Itou J,Kawakami H,Burgoyne T,Kawakami Y
A-11122 was used in immunohistochemistry to test if aging affects the regenerative potential of zebrafish
Wed Aug 15 00:00:00 UTC 2012
Dual fluorescence detection of protein and RNA in Drosophila tissues.
Nature protocols
Toledano H,D'Alterio C,Loza-Coll M,Jones DL
A-11122 was used in Immunohistochemistry to describe a protocol that combines whole-mount immunofluorescence (IF) and fluorescence in situ hybridization (FISH) for the simultaneous detection of specific RNA transcripts and proteins, greatly enhancing the spatial resolution of RNA expression in complex, intact fly tissues.
Mon Oct 01 00:00:00 UTC 2012
Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy.
BMC medical genetics
Rajkumar R,Sembrat JC,McDonough B,Seidman CE,Ahmad F
A-11122 was used in western blot to elucidate the mechanisms of the Ser358Leu mutation in TMEM43 in arrhythmogenic right ventricular cardiomyopathy.
Thu Mar 29 00:00:00 UTC 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
The Journal of biological chemistry
She K,Ferreira JS,Carvalho AL,Craig AM
A-11122 was used in immunocytochemistry to study the control of NMDA receptor surface trafficking by the binding of glutamate to GluN2B subunits.
Fri Aug 10 00:00:00 UTC 2012
A transcription factor-based mechanism for mouse heterochromatin formation.
Nature structural & molecular biology
Bulut-Karslioglu A,Perrera V,Scaranaro M,de la Rosa-Velazquez IA,van de Nobelen S,Shukeir N,Popow J,Gerle B,Opravil S,Pagani M,Meidhof S,Brabletz T,Manke T,Lachner M,Jenuwein T
A-11122 was used in immunocytochemistry to show that Pax3 and Pax9 ara redundant regulators of mouse heterochromatin.
Mon Oct 01 00:00:00 UTC 2012
Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum.
BMC neuroscience
Rapacioli M,Botelho J,Cerda G,Duarte S,Elliot M,Palma V,Flores V
A-11122 was used in immunohistochemistry to examine the effect of sonic hedgehog signaling activation on the proliferation dynamics and the spatial organization of chicken neuroepithelial cell proliferation activity
Tue Oct 02 00:00:00 UTC 2012
A versatile method for cell-specific profiling of translated mRNAs in Drosophila.
PloS one
Thomas A,Lee PJ,Dalton JE,Nomie KJ,Stoica L,Costa-Mattioli M,Chang P,Nuzhdin S,Arbeitman MN,Dierick HA
A-11122 was used in immunohistochemistry and western blot to describe a method to profile almost any tissue/cell-type with a single genetic cross.
Tue Apr 02 00:00:00 UTC 2013
Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome.
PLoS genetics
Wollmann H,Holec S,Alden K,Clarke ND,Jacques PÉ,Berger F
A-11122 was used in immunoprecipitation to characterize the common properties of Arabidopsis H3 variants.
Wed Sep 26 00:00:00 UTC 2012
Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis.
Developmental cell
Bogdanović O,Delfino-Machín M,Nicolás-Pérez M,Gavilán MP,Gago-Rodrigues I,Fernández-Miñán A,Lillo C,Ríos RM,Wittbrodt J,Martínez-Morales JR
A-11122 was used in Immunocytochemistry to propose that developmental regulator Opo enables polarized integrin localization by modulating Numb/Numbl, thus directing the basal constriction that shapes the vertebrate retina epithelium.
Tue Oct 16 00:00:00 UTC 2012
Stretching the rules: monocentric chromosomes with multiple centromere domains.
PLoS genetics
Neumann P,Navrátilová A,Schroeder-Reiter E,Koblížková A,Steinbauerová V,Chocholová E,Novák P,Wanner G,Macas J
A-11122 was used in immunohistochemistry to propose Pisum as a useful model to study centromere architecture.
Wed Sep 26 00:00:00 UTC 2012
A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
The Journal of biological chemistry
Qadota H,Moerman DG,Benian GM
A-11122 was used in immunohistochemistry to elucidate PAT-4 and UNC-2 binding.
Fri Aug 17 00:00:00 UTC 2012
Whole-mount confocal microscopy for vascular branching morphogenesis.
Methods in molecular biology (Clifton, N.J.)
Mukouyama YS,James J,Nam J,Uchida Y
A-11122 was used in immunocytochemistry to visualize the vascular network forming in mouse embryonic tissues.
Thu Apr 26 00:00:00 UTC 2012
Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala.
Frontiers in neural circuits
Geracitano R,Fischer D,Kasugai Y,Ferraguti F,Capogna M
A-11122 was used in immunohistochemistry - free floating to determine if alpha1 or alpha2/alpha3 subunits are expressed at intercalated medial paracapsular cell synapses
Tue Oct 02 00:00:00 UTC 2012
Midline crossing is not required for subsequent pathfinding decisions in commissural neurons.
Neural development
Bonner J,Letko M,Nikolaus OB,Krug L,Cooper A,Chadwick B,Conklin P,Lim A,Chien CB,Dorsky RI
A-11122 was used in immunohistochemistry to perform single-cell analysis of axon guidance mechanisms
Wed Jun 06 00:00:00 UTC 2012
GO-PROMTO illuminates protein membrane topologies of glycan biosynthetic enzymes in the Golgi apparatus of living tissues.
PloS one
Søgaard C,Stenbæk A,Bernard S,Hadi M,Driouich A,Scheller HV,Sakuragi Y
A-11122 was used in western blot to develop a non-invasive method to study the membrane topologies of Golgi-resident proteins.
Fri Jun 29 00:00:00 UTC 2012
The role of the bHLH protein hairy in morphogenetic furrow progression in the developing Drosophila eye.
PloS one
Bhattacharya A,Baker NE
A-11122 was used in immunohistochemistry to examine the relationships among hairy, daughterless, and other HLH genes.
Thu May 09 00:00:00 UTC 2013
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.
The Journal of biological chemistry
Ouyang H,Ali YO,Ravichandran M,Dong A,Qiu W,MacKenzie F,Dhe-Paganon S,Arrowsmith CH,Zhai RG
A-11122 was used in immunocytochemistry to determine the role of HDAC6 in aggresome formation.
Fri Jan 20 00:00:00 UTC 2012
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
PloS one
McCoy ES,Taylor-Blake B,Zylka MJ
A-11122 was used in immunohistochemistry to identify stimuli for nociceptive dorsal root ganglia neurons.
Fri Sep 21 00:00:00 UTC 2012
COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Nature
Vitari AC,Leong KG,Newton K,Yee C,O'Rourke K,Liu J,Phu L,Vij R,Ferrando R,Couto SS,Mohan S,Pandita A,Hongo JA,Arnott D,Wertz IE,Gao WQ,French DM,Dixit VM
A-11122 was used in western blot to investigate post-translational regulation of ETS family and their roles in prostatic tumorgenesis.
Sun May 15 00:00:00 UTC 2011
A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins.
Nature methods
Kleinlogel S,Terpitz U,Legrum B,Gökbuget D,Boyden ES,Bamann C,Wood PG,Bamberg E
A-11122 was used in immunocytochemistry and western blot to develop a gene-fusion strategy for the stable : expression of any two microbial rhodopsins in a single polypeptide chain.
Sun Nov 06 00:00:00 UTC 2011
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function.
Nature methods
Zhao S,Ting JT,Atallah HE,Qiu L,Tan J,Gloss B,Augustine GJ,Deisseroth K,Luo M,Graybiel AM,Feng G
A-11122 was used in immunohistochemistry to generate and characterize cell type-specific ChR2(H134R) mouse lines
Thu Sep 01 00:00:00 UTC 2011
mGRASP enables mapping mammalian synaptic connectivity with light microscopy.
Nature methods
Kim J,Zhao T,Petralia RS,Yu Y,Peng H,Myers E,Magee JC
A-11122 was used in immunohistochemistry to develop mammalian GFP reconstitution across synaptic partners (GRASP).
Sun Dec 04 00:00:00 UTC 2011
NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.
Blood
Urso K,Alfranca A,Martínez-Martínez S,Escolano A,Ortega I,Rodríguez A,Redondo JM
A-11122 was used in immunocytochemistry to study NFATc3 in T cells.
Thu Jul 21 00:00:00 UTC 2011
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Neuron
Ruiz de Almodovar C,Fabre PJ,Knevels E,Coulon C,Segura I,Haddick PC,Aerts L,Delattin N,Strasser G,Oh WJ,Lange C,Vinckier S,Haigh J,Fouquet C,Gu C,Alitalo K,Castellani V,Tessier-Lavigne M,Chedotal A,Charron F,Carmeliet P
A-11122 was used in immunohistochemistry to report that secreted VEGF is a chemoattractant for commissural axons in vitro and in vivo.
Thu Jun 09 00:00:00 UTC 2011
Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers.
Nature chemical biology
Qin K,Dong C,Wu G,Lambert NA
A-11122 was used in ELISA to report that M(3) muscarinic acetylcholine receptors form inactive-state complexes with G(q) heterotrimers in intact cells
Sun Aug 28 00:00:00 UTC 2011
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Autophagy
Huang J,Birmingham CL,Shahnazari S,Shiu J,Zheng YT,Smith AC,Campellone KG,Heo WD,Gruenheid S,Meyer T,Welch MD,Ktistakis NT,Kim PK,Klionsky DJ,Brumell JH
A-11122 was used in Western Blotting to study the mechanism of autophagosome formation, to better understand the autophagy of eukaryotic cells in immunity.
Sat Jan 01 00:00:00 UTC 2011
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.
Autophagy
Cemma M,Kim PK,Brumell JH
A-11122 was used in western blot to report that p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy
Tue Mar 01 00:00:00 UTC 2011
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Cancer research
Meyer DS,Brinkhaus H,Müller U,Müller M,Cardiff RD,Bentires-Alj M
A-11122 was used in immunohistochemistry to elucidate the contribution of PIK3CA H1047R to breast cancer pathogenesis.
Fri Jul 01 00:00:00 UTC 2011
Leptin regulates energy balance and motivation through action at distinct neural circuits.
Biological psychiatry
Davis JF,Choi DL,Schurdak JD,Fitzgerald MF,Clegg DJ,Lipton JW,Figlewicz DP,Benoit SC
A-11122 was used in blocking or activating experiment to test if leptin signaling within the lateral hypothalamus and midbrain is involved in effort-based responding for food rewards and/or modulation of mesolimbic dopamine
Fri Apr 01 00:00:00 UTC 2011
Engineering the ABA plant stress pathway for regulation of induced proximity.
Science signaling
Liang FS,Ho WQ,Crabtree GR
A-11122 was used in western blot to use the plant abscisic acid stress response pathway to regulate transcription, signal transduction, and subcellular localization of proteins.
Tue Mar 15 00:00:00 UTC 2011
Polycomb proteins regulate the quantitative induction of VERNALIZATION INSENSITIVE 3 in response to low temperatures.
The Plant journal : for cell and molecular biology
Jean Finnegan E,Bond DM,Buzas DM,Goodrich J,Helliwell CA,Tamada Y,Yun JY,Amasino RM,Dennis ES
A-11122 was used in ChIP assay to investigate the epigenetic regulation of vernalization.
Tue Feb 01 00:00:00 UTC 2011
Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.
Development (Cambridge, England)
Loebel DA,Studdert JB,Power M,Radziewic T,Jones V,Coultas L,Jackson Y,Rao RS,Steiner K,Fossat N,Robb L,Tam PP
A-11122 was used in immunohistochemistry - frozen section to study the role of Rhou in development.
Sat Oct 01 00:00:00 UTC 2011
Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Valiente M,Ciceri G,Rico B,Marín O
A-11122 was used in western blot to examine the function of focal adhesion kinase in cortical interneurons and pyramidal cells.
Wed Aug 10 00:00:00 UTC 2011
Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fricker FR,Lago N,Balarajah S,Tsantoulas C,Tanna S,Zhu N,Fageiry SK,Jenkins M,Garratt AN,Birchmeier C,Bennett DL
A-11122 was used in immunohistochemistry to examine the contribution of neuregulin-1 after injury.
Wed Mar 02 00:00:00 UTC 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sato H,Arawaka S,Hara S,Fukushima S,Koga K,Koyama S,Kato T
A-11122 was used in immunohistochemistry to elucidate the role of Ser129 phosphorylation in α-syn neurotoxicity.
Wed Nov 16 00:00:00 UTC 2011
A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boersma MC,Dresselhaus EC,De Biase LM,Mihalas AB,Bergles DE,Meffert MK
A-11122 was used in immunocytochemistry to study the role of p65 in dendritic spine formation and morphology in murine hippocampal neurons.
Wed Apr 06 00:00:00 UTC 2011
Samp1 is functionally associated with the LINC complex and A-type lamina networks.
Journal of cell science
Gudise S,Figueroa RA,Lindberg R,Larsson V,Hallberg E
A-11122 was used in western blot to demonstrate that Samp1 is functionally associated with Sun1 and the A-type lamina network.
Wed Jun 15 00:00:00 UTC 2011
Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity.
Endocrinology
Krawczewski Carhuatanta KA,Demuro G,Tschöp MH,Pfluger PT,Benoit SC,Obici S
A-11122 was used in immunocytochemistry to investigate the effects of exercise on obesity and the central nervous system using mice.
Fri Jul 01 00:00:00 UTC 2011
Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease.
Investigative ophthalmology & visual science
Prentice HM,Biswal MR,Dorey CK,Blanks JC
A-11122 was used in immunohistochemistry to generate and assess a hypoxia-regulated, retinal glial cell-specific vector.
Tue Nov 01 00:00:00 UTC 2011
Endoglin suppresses human prostate cancer metastasis.
Clinical & experimental metastasis
Lakshman M,Huang X,Ananthanarayanan V,Jovanovic B,Liu Y,Craft CS,Romero D,Vary CP,Bergan RC
A-11122 was used in immunohistochemistry to study endoglin-mediated contributions to cancer progression
Sat Jan 01 00:00:00 UTC 2011
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
The Journal of pharmacology and experimental therapeutics
Kleiman RJ,Kimmel LH,Bove SE,Lanz TA,Harms JF,Romegialli A,Miller KS,Willis A,des Etages S,Kuhn M,Schmidt CJ
A-11122 was used in immunohistochemistry to test if chronic suppression of PDE10A activity affects gene expression in the striatum
Sat Jan 01 00:00:00 UTC 2011
Two regions within the proximal steroidogenic factor 1 promoter drive somatic cell-specific activity in developing gonads of the female mouse.
Biology of reproduction
Gao L,Kim Y,Kim B,Lofgren SM,Schultz-Norton JR,Nardulli AM,Heckert LL,Jorgensen JS
A-11122 was used in immunohistochemistry - frozen section to test if the sexually dimorphic expression of Sf1 during gonadogenesis is mediated by sex-specific regulation of its promoter
Tue Mar 01 00:00:00 UTC 2011
A neuroregenerative human ensheathing glia cell line with conditional rapid growth.
Cell transplantation
García-Escudero V,Gargini R,Gallego-Hernández MT,García-Gómez A,Martín-Bermejo MJ,Simón D,Delicado A,Moreno-Flores MT,Avila J,Lim F
A-11122 was used in immunohistochemistry to generate and characterize human ensheathing glia cell lines
Tue Aug 23 00:00:00 UTC 2011
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.
Molecular biology of the cell
Leung A,Cajigas I,Jia P,Ezhkova E,Brickner JH,Zhao Z,Geng F,Tansey WP
A-11122 was used in immunocytochemistry to report that histone modifications are required for cell wall integrity at high temperatures
Mon Aug 01 00:00:00 UTC 2011
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Behavioural brain research
Ramirez JJ,Poulton WE,Knelson E,Barton C,King MA,Klein RL
A-11122 was used in Immunohistochemistry to determine whether adult onset Alzheimer's disease, spatially restricted tauopathy could be sufficient to reproduce progressive deficits in mnemonic function.
Sat Jan 01 00:00:00 UTC 2011
Neurovascular development in the embryonic zebrafish hindbrain.
Developmental biology
Ulrich F,Ma LH,Baker RG,Torres-Vázquez J
A-11122 was used in immunohistochemistry to investigate the assembly of the cerebral vasculature.
Thu Sep 01 00:00:00 UTC 2011
Characterization of last-order premotor interneurons by transneuronal tracing with rabies virus in the neonatal mouse spinal cord.
The Journal of comparative neurology
Coulon P,Bras H,Vinay L
A-11122 was used in immunohistochemistry to evaluate a strategy of transneuronal tracing with rabies virus in the neonatal mouse spinal cord.
Thu Dec 01 00:00:00 UTC 2011
Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations.
The Journal of comparative neurology
Marcucci F,Maier-Balough E,Zou DJ,Firestein S
A-11122 was used in immunohistochemistry to test if olfactory sensory projections are established in an exuberant fashion.
Thu Dec 15 00:00:00 UTC 2011
Dual-labeling method for electron microscopy to characterize synaptic connectivity using genetically encoded fluorescent reporters in Drosophila.
Journal of neuroscience methods
Tanaka NK,Dye L,Stopfer M
A-11122 was used in immunohistochemistry to develop a dual-labeling method to study the synaptic connectivity of neurons
Sat Jan 15 00:00:00 UTC 2011
An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis.
Genesis (New York, N.Y. : 2000)
Li Y,Tian C,Yang Y,Yan Y,Ni Y,Wei Y,Pleasure SJ,Zhao C
A-11122 was used in immunohistochemistry to use transgenic mice to study hippocampal development and adult neurogenesis.
Thu Dec 01 00:00:00 UTC 2011
Tuning protein expression using synonymous codon libraries targeted to the 5' mRNA coding region.
Protein engineering, design & selection : PEDS
Goltermann L,Borch Jensen M,Bentin T
A-11122 was used in western blot to report that the 5' mRNA coding region near the AUG start codon is crucial for determining translation output
Sat Jan 01 00:00:00 UTC 2011
OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation.
Nature protocols
Liu Y,Jiang P,Deng W
A-11122 was used in Immunocytochemistry-immunofluorescence to describe a gene-targeting protocol to knock in a GFP cassette into key gene loci in human pluripotent stem cells (hPSCs), and then use the genetically tagged hPSCs to guide in vitro differentiation, immunocytochemical and electrophysiological profiling and in vivo characterization after cell transplantation.
Sun May 01 00:00:00 UTC 2011
Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.
PloS one
Leppä E,Linden AM,Vekovischeva OY,Swinny JD,Rantanen V,Toppila E,Höger H,Sieghart W,Wulff P,Wisden W,Korpi ER
A-11122 was used in immunohistochemistry to study the behavioral significance of fast synaptic inhibition by alphabetagamma2-type GABA(A) receptors on parvalbumin cells
Thu Dec 29 00:00:00 UTC 2011
Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines.
Molecular vision
Ryals RC,Boye SL,Dinculescu A,Hauswirth WW,Boye SE
A-11122 was used in immunocytochemistry to determine the transduction efficiencies of a variety of adeno-associated virus vectors using ocular cell lines.
Fri Apr 29 00:00:00 UTC 2011
Ultra light-sensitive and fast neuronal activation with the Ca²+-permeable channelrhodopsin CatCh.
Nature neuroscience
Kleinlogel S,Feldbauer K,Dempski RE,Fotis H,Wood PG,Bamann C,Bamberg E
A-11122 was used in Immunocytochemistry-immunofluorescence to present a new variant, calcium translocating channelrhodopsin (CatCh), which mediates an accelerated response time and a voltage response that is ~70-fold more light sensitive than that of wild-type ChR2.
Fri Apr 01 00:00:00 UTC 2011
Bi-modal regulation of a formin by srGAP2.
The Journal of biological chemistry
Mason FM,Heimsath EG,Higgs HN,Soderling SH
A-11122 was used in western blot to study how srGAP2 and formin-like 1 regulate actin dynamics.
Fri Feb 25 00:00:00 UTC 2011
The circadian molecular clock creates epidermal stem cell heterogeneity.
Nature
Janich P,Pascual G,Merlos-Suárez A,Batlle E,Ripperger J,Albrecht U,Cheng HY,Obrietan K,Di Croce L,Benitah SA
A-11122 was used in Immunohistochemistry to indicate that the circadian clock fine-tunes the temporal behaviour of epidermal stem cells, and that its perturbation affects homeostasis and the predisposition to tumorigenesis.
Wed Nov 09 00:00:00 UTC 2011
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.
The Journal of biological chemistry
Fassler M,Li X,Kaether C
A-11122 was used in immunoprecipitation and western blot to study the TMD4 of presenilin 1 and identify polar amino acids critical for γ-secretase assembly and function.
Fri Nov 04 00:00:00 UTC 2011
Different fear states engage distinct networks within the intercalated cell clusters of the amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Busti D,Geracitano R,Whittle N,Dalezios Y,Mańko M,Kaufmann W,Sätzler K,Singewald N,Capogna M,Ferraguti F
A-11122 was used in Immunohistochemistry to elucidate their role in fear expression and extinction.
Wed Mar 30 00:00:00 UTC 2011
Calpain activation by Wingless-type murine mammary tumor virus integration site family, member 5A (Wnt5a) promotes axonal growth.
The Journal of biological chemistry
Yang GY,Liang B,Zhu J,Luo ZG
A-11122 was used in western blot to report a role for Wnt/calcium signaling in regulating actin and growth cone dynamics.
Fri Feb 25 00:00:00 UTC 2011
Cellular mechanisms underlying the regulation of dendritic development by hepatocyte growth factor.
The European journal of neuroscience
Finsterwald C,Martin JL
A-11122 was used in Immunocytochemistry-immunofluorescence to support the conclusion that regulation of cortical dendritic morphology by hepatocyte growth factor is mediated by activation of the MAPK pathway, phosphorylation of CREB and interaction of CREB with CRTC1.
Sat Oct 01 00:00:00 UTC 2011
HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.
PloS one
Lu SM,Tremblay MÈ,King IL,Qi J,Reynolds HM,Marker DF,Varrone JJ,Majewska AK,Dewhurst S,Gelbard HA
A-11122 was used in immunohistochemistry to test if central or peripheral myeloid lineage cells contribute to synaptic damage during acute neuroinflammation during HIV infection.
Thu Dec 29 00:00:00 UTC 2011
Dissection and staining of Drosophila optic lobes at different stages of development.
Cold Spring Harbor protocols
Morante J,Desplan C
A-11122 was used in immunohistochemistry to examine Drosophila optic lobes at different stages of development.
Wed Jun 01 00:00:00 UTC 2011
Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation.
The Journal of biological chemistry
Hochbaum D,Barila G,Ribeiro-Neto F,Altschuler DL
A-11122 was used in immunocytochemistry to identify radixin as a scaffolding unit for Epac and PKA
Fri Jan 07 00:00:00 UTC 2011
Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation.
PLoS genetics
Budi EH,Patterson LB,Parichy DM
A-11122 was used in immunohistochemistry to study the morphogenesis and differentiation of pigment cells in various post-embryonic stages
Sun May 01 00:00:00 UTC 2011
Genetic dissection of an amygdala microcircuit that gates conditioned fear.
Nature
Haubensak W,Kunwar PS,Cai H,Ciocchi S,Wall NR,Ponnusamy R,Biag J,Dong HW,Deisseroth K,Callaway EM,Fanselow MS,Lüthi A,Anderson DJ
A-11122 was used in immunohistochemistry to map the functional connectivity of a subpopulation of GABA-containing neurons
Thu Nov 11 00:00:00 UTC 2010
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Cell
Hailey DW,Rambold AS,Satpute-Krishnan P,Mitra K,Sougrat R,Kim PK,Lippincott-Schwartz J
A-11122 was used in immunocytochemistry to report that the mitochondrial outer membrane participates in autophagosome biogenesis
Fri May 14 00:00:00 UTC 2010
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Nature cell biology
Smith FD,Langeberg LK,Cellurale C,Pawson T,Morrison DK,Davis RJ,Scott JD
A-11122 was used in immunoprecipitation and western blot to elucidate the role for A-kinase-anchoring protein AKAP-Lbc in MAPK signaling
Wed Dec 01 00:00:00 UTC 2010
RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.
Nature cell biology
Siekhaus D,Haesemeyer M,Moffitt O,Lehmann R
A-11122 was used in immunohistochemistry to identify factors that regulate immune cell transmigration using fruit flies
Tue Jun 01 00:00:00 UTC 2010
The development of tissue-engineered bone of different origin through endochondral and intramembranous ossification following the implantation of mesenchymal stem cells and osteoblasts in a murine model.
Biomaterials
Tortelli F,Tasso R,Loiacono F,Cancedda R
A-11122 was used in immunohistochemistry to investigate host cell recruitment to ceramic scaffolds
Fri Jan 01 00:00:00 UTC 2010
FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells.
Cancer research
Gupta S,Iljin K,Sara H,Mpindi JP,Mirtti T,Vainio P,Rantala J,Alanen K,Nees M,Kallioniemi O
A-11122 was used in western blot to elucidate mechanisms and pathways that regulate ERG-mediated oncogenesis
Wed Sep 01 00:00:00 UTC 2010
The Plant Homeo Domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5.
Proceedings of the National Academy of Sciences of the United States of America
Kim DH,Sung S
A-11122 was used in immunoprecipitation to examine the pathway to flowering in noninductive photoperiods
Tue Sep 28 00:00:00 UTC 2010
Plasma membrane-localized transporter for aluminum in rice.
Proceedings of the National Academy of Sciences of the United States of America
Xia J,Yamaji N,Kasai T,Ma JF
A-11122 was used in immunocytochemistry to identify Nrat1 as the aluminum transporter of rice
Tue Oct 26 00:00:00 UTC 2010
Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Nicolaï LJ,Ramaekers A,Raemaekers T,Drozdzecki A,Mauss AS,Yan J,Landgraf M,Annaert W,Hassan BA
A-11122 was used in immunohistochemistry to establish a genetically encoded, specific, universal, and phenotypically neutral marker of the somatodendritic compartment of Drosophilia
Tue Nov 23 00:00:00 UTC 2010
Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion.
Oncogene
Nevo J,Mai A,Tuomi S,Pellinen T,Pentikäinen OT,Heikkilä P,Lundin J,Joensuu H,Bono P,Ivaska J
A-11122 was used in proximity ligation assay and western blot to explore the contribution of mammary-derived growth inhibitor to breast cancer invasion
Thu Dec 09 00:00:00 UTC 2010
Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.
The Journal of cell biology
Day TA,Palle K,Barkley LR,Kakusho N,Zou Y,Tateishi S,Verreault A,Masai H,Vaziri C
A-11122 was used in immunoprecipitation to investigate the regulation of Rad18 during DNA damage and the cell cycle
Mon Nov 29 00:00:00 UTC 2010
Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.
Development (Cambridge, England)
Zonies S,Motegi F,Hao Y,Seydoux G
A-11122 was used in immunohistochemistry - frozen section to describe a role for PAR-2 in the polarization of the C. elegans zygote
Sat May 01 00:00:00 UTC 2010
Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ruiz de Almodovar C,Coulon C,Salin PA,Knevels E,Chounlamountri N,Poesen K,Hermans K,Lambrechts D,Van Geyte K,Dhondt J,Dresselaers T,Renaud J,Aragones J,Zacchigna S,Geudens I,Gall D,Stroobants S,Mutin M,Dassonville K,Storkebaum E,Jordan BF,Eriksson U,Moons L,D'Hooge R,Haigh JJ,Belin MF,Schiffmann S,Van Hecke P,Gallez B,Vinckier S,Chédotal A,Honnorat J,Thomasset N,Carmeliet P,Meissirel C
A-11122 was used in immunohistochemistry to report a role for VEGF in the regulation of cerebellar granule cell migration from the external granule cell layer toward the Purkinje cell layer
Wed Nov 10 00:00:00 UTC 2010
LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Siddiqui TJ,Pancaroglu R,Kang Y,Rooyakkers A,Craig AM
A-11122 was used in immunocytochemistry to characterize the role of neurexins in synaptic differentiation and development
Wed Jun 02 00:00:00 UTC 2010
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Novak M,Halbout B,O'Connor EC,Rodriguez Parkitna J,Su T,Chai M,Crombag HS,Bilbao A,Spanagel R,Stephens DN,Schütz G,Engblom D
A-11122 was used in immunohistochemistry to use transgenic mice to study the role of mGluR5 in drug addiction
Wed Sep 08 00:00:00 UTC 2010
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ables JL,Decarolis NA,Johnson MA,Rivera PD,Gao Z,Cooper DC,Radtke F,Hsieh J,Eisch AJ
A-11122 was used in immunohistochemistry - free floating to study the role of Notch1 in maintaining a reservoir of adult hippocampal stem cells
Wed Aug 04 00:00:00 UTC 2010
Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.
Cytotherapy
Gaur M,Ritner C,Sievers R,Pedersen A,Prasad M,Bernstein HS,Yeghiazarians Y
A-11122 was used in immunohistochemistry - paraffin section to investigate the differentiation human embryonic stem cells into cardiomyocytes
Fri Oct 01 00:00:00 UTC 2010
Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Leibiger B,Moede T,Uhles S,Barker CJ,Creveaux M,Domin J,Berggren PO,Leibiger IB
A-11122 was used in immunoprecipitation to show that in response to insulin, PI3K-C2alpha generates PI(3,4)P(2) and the selective activation of PKBalpha/Akt1
Tue Jun 01 00:00:00 UTC 2010
The Bax carboxy-terminal hydrophobic helix does not determine organelle-specific targeting but is essential for maintaining Bax in an inactive state and for stable mitochondrial membrane insertion.
Apoptosis : an international journal on programmed cell death
Brock SE,Li C,Wattenberg BW
A-11122 was used in immunocytochemistry and western blot to investigate the function of the hydrophobic carboxy-terminal tail of Bax
Fri Jan 01 00:00:00 UTC 2010
Widespread enzymatic correction of CNS tissues by a single intracerebral injection of therapeutic lentiviral vector in leukodystrophy mouse models.
Human molecular genetics
Lattanzi A,Neri M,Maderna C,di Girolamo I,Martino S,Orlacchio A,Amendola M,Naldini L,Gritti A
A-11122 was used in Western Blotting to target the external capsule, a white matter area, to obtain maximal CNS enzymatic correction from a single injection site in leukodystrophies.
Tue Jun 01 00:00:00 UTC 2010
Regulation of RB transcription in vivo by RB family members.
Molecular and cellular biology
Burkhart DL,Ngai LK,Roake CM,Viatour P,Thangavel C,Ho VM,Knudsen ES,Sage J
A-11122 was used in immunohistochemistry - frozen section to explore how the RB/E2F pathway regulate Rb transcription
Thu Apr 01 00:00:00 UTC 2010
Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material.
Journal of vascular surgery
Enomoto S,Sumi M,Kajimoto K,Nakazawa Y,Takahashi R,Takabayashi C,Asakura T,Sata M
A-11122 was used in immunohistochemistry to determine the potential of fibroin to generate a vascular prosthesis for small arteries
Fri Jan 01 00:00:00 UTC 2010
Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric mice.
The Journal of endocrinology
Ma DF,Sudo K,Tezuka H,Kondo T,Nakazawa T,Niu DF,Kawasaki T,Mochizuki K,Yamane T,Katoh R
A-11122 was used in immunohistochemistry to report embryonal patch patterns of endocrine organs and the polyclonality of hormone-producing cell populations using chimeric mice
Fri Oct 01 00:00:00 UTC 2010
Refinement of tools for targeted gene expression in Drosophila.
Genetics
Pfeiffer BD,Ngo TT,Hibbard KL,Murphy C,Jenett A,Truman JW,Rubin GM
A-11122 was used in immunohistochemistry to optimize gene expression reagents and protocols for Drosophila melanogaster
Fri Oct 01 00:00:00 UTC 2010
Clonal differentiation of skeletal muscle-derived CD34(-)/45(-) stem cells into cardiomyocytes in vivo.
Stem cells and development
Tamaki T,Uchiyama Y,Okada Y,Tono K,Masuda M,Nitta M,Hoshi A,Akatsuka A
A-11122 was used in immunohistochemistry to test if skeletal muscle-derived stem cells differentiate into cardiac muscle cells
Thu Apr 01 00:00:00 UTC 2010
A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse.
Journal of neuroendocrinology
Fiorini Z,Jasoni CL
A-11122 was used in immunohistochemistry to assess the role of KISS1 in the normal growth of GnRH neurites to the median eminence
Fri Oct 01 00:00:00 UTC 2010
Extracerebellar progenitors grafted to the neurogenic milieu of the postnatal rat cerebellum adapt to the host environment but fail to acquire cerebellar identities.
The European journal of neuroscience
Rolando C,Gribaudo S,Yoshikawa K,Leto K,De Marchis S,Rossi F
A-11122 was used in western blot to investigate the fate of heterotopically transplanted neurons when they are moved to other parts of the central nervous system
Thu Apr 01 00:00:00 UTC 2010
Differential localization and dynamics of class I myosins in the enterocyte microvillus.
Molecular biology of the cell
Benesh AE,Nambiar R,McConnell RE,Mao S,Tabb DL,Tyska MJ
A-11122 was used in immunocytochemistry to suggest that Myo1d is the primary compensating class I myosin in the Myo1a knockout model
Mon Mar 15 00:00:00 UTC 2010
Meiotic cohesin promotes pairing of nonhomologous centromeres in early meiotic prophase.
Molecular biology of the cell
Chuong H,Dawson DS
A-11122 was used in ChIP assay and immunocytochemistry to investigate proteins involved in centromere coupling
Tue Jun 01 00:00:00 UTC 2010
Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes.
Journal of neuropathology and experimental neurology
Tian R,Wu X,Hagemann TL,Sosunov AA,Messing A,McKhann GM,Goldman JE
A-11122 was used in immunocytochemistry to study the role of glutamate transporter in a knock-in mouse model of Alexander disease.
Thu Apr 01 00:00:00 UTC 2010
Neural architecture of the primary gustatory center of Drosophila melanogaster visualized with GAL4 and LexA enhancer-trap systems.
The Journal of comparative neurology
Miyazaki T,Ito K
A-11122 was used in immunocytochemistry to elucidate the anatomy of the insect primary gustatory center.
Fri Oct 15 00:00:00 UTC 2010
Bilateral whisker trimming during early postnatal life impairs dendritic spine development in the mouse somatosensory barrel cortex.
The Journal of comparative neurology
Briner A,De Roo M,Dayer A,Muller D,Kiss JZ,Vutskits L
A-11122 was used in immunohistochemistry to test if and how interference with sensory perception in the early postnatal period affects the development of synaptic networks in rodents.
Sat May 15 00:00:00 UTC 2010
Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets.
The Journal of comparative neurology
Young JM,Armstrong JD
A-11122 was used in immunohistochemistry to elucidate the neuroarchitecture of the central complex.
Sat May 01 00:00:00 UTC 2010
Building the central complex in Drosophila: the generation and development of distinct neural subsets.
The Journal of comparative neurology
Young JM,Armstrong JD
A-11122 was used in immunohistochemistry to study the development of the four central complex structures and central complex neurons in the Drosophila brain.
Sat May 01 00:00:00 UTC 2010
Physiological and morphological characterization of local interneurons in the Drosophila antennal lobe.
Journal of neurophysiology
Seki Y,Rybak J,Wicher D,Sachse S,Hansson BS
A-11122 was used in immunohistochemistry to characterize local interneurons
Sun Aug 01 00:00:00 UTC 2010
Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.
Developmental dynamics : an official publication of the American Association of Anatomists
Bax NA,Bleyl SB,Gallini R,Wisse LJ,Hunter J,Van Oorschot AA,Mahtab EA,Lie-Venema H,Goumans MJ,Betsholtz C,Gittenberger-de Groot AC
A-11122 was used in immunohistochemistry to determine the role of Pdgfralpha in the heart
Sun Aug 01 00:00:00 UTC 2010
A mouse tool for conditional mutagenesis in ovarian granulosa cells.
Genesis (New York, N.Y. : 2000)
Grabner B,Blaas L,Musteanu M,Hoffmann T,Birbach A,Eferl R,Casanova E
A-11122 was used in immunohistochemistry - paraffin section to establish an inducible Cre transgenic line that allows conditional mutagenesis in ovarian granulosa cells
Fri Oct 01 00:00:00 UTC 2010
A mouse line expressing Sall1-driven inducible Cre recombinase in the kidney mesenchyme.
Genesis (New York, N.Y. : 2000)
Inoue S,Inoue M,Fujimura S,Nishinakamura R
A-11122 was used in immunohistochemistry - paraffin section to develop the Sall1CreER(T2) mouse line to study time- and tissue-specific Sall1 deficient mice
Mon Mar 01 00:00:00 UTC 2010
Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ideguchi M,Palmer TD,Recht LD,Weimann JM
A-11122 was used in Immunocytochemistry to establish that ES-derived cortical projection neurons can integrate into anatomically relevant circuits.
Wed Jan 20 00:00:00 UTC 2010
Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs.
BMC developmental biology
Tulin S,Stathopoulos A
A-11122 was used in immunocytochemistry to investigate regulation of Fibroblast Growth Factor activity
Thu Aug 05 00:00:00 UTC 2010
In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish.
PloS one
Prykhozhij SV
A-11122 was used in ChIP assay and western blot to discuss processes regulated by sonic hedgehog signaling
Thu Oct 21 00:00:00 UTC 2010
The functional interplay between protein kinase CK2 and CCA1 transcriptional activity is essential for clock temperature compensation in Arabidopsis.
PLoS genetics
Portolés S,Más P
A-11122 was used in ChIP assay and western blot to study the Arabidopsis thaliana circadian system
Thu Nov 04 00:00:00 UTC 2010
Genetic fate mapping using site-specific recombinases.
Methods in enzymology
Legué E,Joyner AL
A-11122 was used in Immunohistochemistry to enable genetic fate mapping studies, employing intrachromosomal recombination methods, including cumulative, inducible, clonal, and intersectional approaches, as well as an interchromosomal method, in order to mark and trace distinct cell types during development, regeneration, or in response to injury.
Fri Dec 10 00:00:00 UTC 2010
ZF21 protein regulates cell adhesion and motility.
The Journal of biological chemistry
Nagano M,Hoshino D,Sakamoto T,Kawasaki N,Koshikawa N,Seiki M
A-11122 was used in immunocytochemistry to identify ZF21 as a regulator of focal adhesion and cell movement
Fri Jul 02 00:00:00 UTC 2010
Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development.
BMC developmental biology
Firth LC,Bhattacharya A,Baker NE
A-11122 was used in immunohistochemistry to review the role of Dpp in eye development
Tue Mar 09 00:00:00 UTC 2010
Labeling and imaging cells in the zebrafish hindbrain.
Journal of visualized experiments : JoVE
Jayachandran P,Hong E,Brewster R
A-11122 was used in immunohistochemistry - paraffin section to establish a GFP-based method to study cells undergoing neurulation
Sun Jul 25 00:00:00 UTC 2010
The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.
Circulation research
Epting D,Wendik B,Bennewitz K,Dietz CT,Driever W,Kroll J
A-11122 was used in Immunohistochemistry to investigate the function of ELMO1/DOCK180 in vascular development.
Fri Jul 09 00:00:00 UTC 2010
The Arabidopsis bZIP transcription factor HY5 regulates expression of the PFG1/MYB12 gene in response to light and ultraviolet-B radiation.
Plant, cell & environment
Stracke R,Favory JJ,Gruber H,Bartelniewoehner L,Bartels S,Binkert M,Funk M,Weisshaar B,Ulm R
A-11122 was used in ChIP assay to suggest that HY5-dependent regulation of PFG gene expression contributes to the establishment of UV-B tolerance.
Fri Jan 01 00:00:00 UTC 2010
The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.
PloS one
Isomura H,Stinski MF,Murata T,Nakayama S,Chiba S,Akatsuka Y,Kanda T,Tsurumi T
A-11122 was used in western blot to discuss human cytomegalovirus genes needed for viral replication
Fri Jul 30 00:00:00 UTC 2010
Isolation, enrichment, and maintenance of medulloblastoma stem cells.
Journal of visualized experiments : JoVE
Huang X,Ketova T,Litingtung Y,Chiang C
A-11122 was used in immunocytochemistry to isolate and characterize tumor stem cells derived from several mouse models of medulloblastoma
Wed Sep 01 00:00:00 UTC 2010
Ontogeny of cone photoreceptor mosaics in zebrafish.
The Journal of comparative neurology
Allison WT,Barthel LK,Skebo KM,Takechi M,Kawamura S,Raymond PA
A-11122 was used in Immunohistochemistry to provide baseline data for understanding the development of cone mosaics via comparative analysis of larval and adult cone development in a model species.
Fri Oct 15 00:00:00 UTC 2010
Temporal characterization of homology-independent centromere coupling in meiotic prophase.
PloS one
Obeso D,Dawson DS
A-11122 was used in immunocytochemistry to discuss the homology-independent pairwise association of centromeres
Fri Apr 23 00:00:00 UTC 2010
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.
Nature structural & molecular biology
Seiradake E,Harlos K,Sutton G,Aricescu AR,Jones EY
A-11122 was used in Western Blot to extended signaling arrays.
Thu Apr 01 00:00:00 UTC 2010
Involvement of Exo1b in DNA damage-induced apoptosis.
Nucleic acids research
Bolderson E,Richard DJ,Edelmann W,Khanna KK
A-11122 was used in western blot to study DNA damage-induced apoptosis and the involvement of Exo1b
Mon Jun 01 00:00:00 UTC 2009
Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis.
Cancer letters
Xu WT,Bian ZY,Fan QM,Li G,Tang TT
A-11122 was used in immunohistochemistry - frozen section to investigate the interaction between MSCs and osteosarcoma
Tue Aug 18 00:00:00 UTC 2009
Generation of functional eyes from pluripotent cells.
PLoS biology
Viczian AS,Solessio EC,Lyou Y,Zuber ME
A-11122 was used in immunohistochemistry to determine if functional retinas can be generated from pluripotent Xenopus laevis cells
Sat Aug 01 00:00:00 UTC 2009
Maturation of active zone assembly by Drosophila Bruchpilot.
The Journal of cell biology
Fouquet W,Owald D,Wichmann C,Mertel S,Depner H,Dyba M,Hallermann S,Kittel RJ,Eimer S,Sigrist SJ
A-11122 was used in immunoprecipitation to analyze the function of BRP in active zone assembly
Mon Jul 13 00:00:00 UTC 2009
C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.
Development (Cambridge, England)
Kawano T,Zheng H,Merz DC,Kohara Y,Tamai KK,Nishiwaki K,Culotti JG
A-11122 was used in immunohistochemistry to study the expression and function of MIG-6 in C. elegans
Fri May 01 00:00:00 UTC 2009
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo.
Development (Cambridge, England)
Burtscher I,Lickert H
A-11122 was used in immunohistochemistry to investigate germ-layer formation in mice
Sun Mar 01 00:00:00 UTC 2009
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbas AI,Yadav PN,Yao WD,Arbuckle MI,Grant SG,Caron MG,Roth BL
A-11122 was used in immunohistochemistry - free floating to report that PSD-95 modulates metabotropic 5-HT(2A) and 5-HT(2C) receptor function
Wed Jun 03 00:00:00 UTC 2009
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.
The journal of pain
Garraway SM,Xu Q,Inturrisi CE
A-11122 was used in immunohistochemistry to examine the consequences reduced NR1 expression on NMDA receptor levels and formalin-induced pain behaviors in adult rats
Wed Apr 01 00:00:00 UTC 2009
A role for dynein in the inhibition of germ cell proliferative fate.
Molecular and cellular biology
Dorsett M,Schedl T
A-11122 was used in western blot to reveal a role for the dynein motor complex in the normal differentiation of germ cells
Sun Nov 01 00:00:00 UTC 2009
Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain.
Journal of tissue engineering and regenerative medicine
Tate CC,Shear DA,Tate MC,Archer DR,Stein DG,LaPlaca MC
A-11122 was used in immunohistochemistry to test if matrix-based scaffolds improve cell transplantation therapy
Sun Mar 01 00:00:00 UTC 2009
Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization.
Experimental cell research
Mehmood R,Yasuhara N,Oe S,Nagai M,Yoneda Y
A-11122 was used in western blot to investigate nuclear import of NeuroD1 and E47
Wed Jun 10 00:00:00 UTC 2009
Recruitment of a host's osteoprogenitor cells using exogenous mesenchymal stem cells seeded on porous ceramic.
Tissue engineering. Part A
Tasso R,Augello A,Boccardo S,Salvi S,Caridà M,Postiglione F,Fais F,Truini M,Cancedda R,Pennesi G
A-11122 was used in immunohistochemistry - paraffin section to determine the contribution of the host's circulating progenitor cells after implantation of mesenchymal stem cells/bioscaffold combinations in repairing bone defects
Sat Aug 01 00:00:00 UTC 2009
The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase.
Developmental biology
Hubert A,Anderson P
A-11122 was used in immunohistochemistry to discuss the potential functions of LAF-1 as a helicase and its roles in sex determination
Mon Jun 15 00:00:00 UTC 2009
Prokineticin receptor 2 expression identifies migrating neuroblasts and their subventricular zone transient-amplifying progenitors in adult mice.
The Journal of comparative neurology
Puverel S,Nakatani H,Parras C,Soussi-Yanicostas N
A-11122 was used in immunocytochemistry and immunohistochemistry to study the expression of prokineticin receptor 2 and the identification of migrating neuroblasts in adult mice
Sat Jan 10 00:00:00 UTC 2009
Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus).
The Journal of comparative neurology
Delaunay D,Heydon K,Miguez A,Schwab M,Nave KA,Thomas JL,Spassky N,Martinez S,Zalc B
A-11122 was used in immunohistochemistry to examine the progeny of plp-expressing ventricular cells in the diencephalon.
Thu Jan 01 00:00:00 UTC 2009
Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries.
Genesis (New York, N.Y. : 2000)
Liao WP,Uetzmann L,Burtscher I,Lickert H
A-11122 was used in immunohistochemistry - frozen section to study Sox17 expression in the endodermal and vascular system
Wed Jul 01 00:00:00 UTC 2009
Identification of Wnt-responsive cells in the zebrafish hypothalamus.
Zebrafish
Wang X,Lee JE,Dorsky RI
A-11122 was used in immunohistochemistry to elucidate the exact roles of canonical Wnt signaling in neurogenesis
Sun Mar 01 00:00:00 UTC 2009
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models.
Methods in enzymology
Chu CT,Plowey ED,Dagda RK,Hickey RW,Cherra SJ,Clark RS
A-11122 was used in western blot to analyze autophagy in neurodegeneration and neurite injury utilizing in vivo and in vitro models
Thu Apr 02 00:00:00 UTC 2009
A temporal threshold for formaldehyde crosslinking and fixation.
PloS one
Schmiedeberg L,Skene P,Deaton A,Bird A
A-11122 was used in ChIP assay to determine the amount of time needed for formaldehyde crosslinking
Mon Apr 27 00:00:00 UTC 2009
Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A.
Journal of cell science
Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J
A-11122 was used in Immunoprecipitation to show that DYRK1A moves to the nuclear transcription compartment where it interacts with the intracellular domain of Notch promoting its phosphorylation in the ankyrin domain and reducing its capacity to sustain transcription.
Fri May 15 00:00:00 UTC 2009
PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.
Developmental cell
Krahn MP,Egger-Adam D,Wodarz A
A-11122 was used in Western Blot to show that PP2A dephosphorylates Baz at the conserved serine residue 1085 and thereby antagonizes the kinase activity of PAR-1.
Mon Jun 01 00:00:00 UTC 2009
The synaptonemal complex protein Zip1 promotes bi-orientation of centromeres at meiosis I.
PLoS genetics
Gladstone MN,Obeso D,Chuong H,Dawson DS
A-11122 was used in immunocytochemistry to show that Zip1-mediated pairing of exchange chromosome centromeres promotes an initial, bipolar attachment of microtubules
Tue Dec 01 00:00:00 UTC 2009
Refining the Ciona intestinalis model of central nervous system regeneration.
PloS one
Dahlberg C,Auger H,Dupont S,Sasakura Y,Thorndyke M,Joly JS
A-11122 was used in immunohistochemistry to use the tunicate Ciona intestinalis to study nervous system regeneration
Mon Mar 23 00:00:00 UTC 2009
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.
Nature genetics
Jacoby M,Cox JJ,Gayral S,Hampshire DJ,Ayub M,Blockmans M,Pernot E,Kisseleva MV,Compère P,Schiffmann SN,Gergely F,Riley JH,Pérez-Morga D,Woods CG,Schurmans S
A-11122 was used in Immunohistochemistry-immunofluorescence to investigate mutations in primary cilium signalling defects.
Tue Sep 01 00:00:00 UTC 2009
An Entry/Gateway cloning system for general expression of genes with molecular tags in Drosophila melanogaster.
BMC cell biology
Akbari OS,Oliver D,Eyer K,Pai CY
A-11122 was used in immunohistochemistry to develop a set of Entry/Gateway vectors for expressing fluorescent fusion proteins in Drosophila melanogaster
Thu Jan 29 00:00:00 UTC 2009
Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Howorth PW,Thornton SR,O'Brien V,Smith WD,Nikiforova N,Teschemacher AG,Pickering AE
A-11122 was used in Immunohistochemistry to test the principle that genetic manipulation of their excitability can alter nociception using an adenoviral vector (AVV-PRS-hKir(2.1)) containing a catecholaminergic-selective promoter (PRS) to retrogradely transduce and inhibit the noradrenergic neurons projecting to the lumbar dorsal horn through the expression of a potassium channel (hKir(2.1)).
Wed Oct 14 00:00:00 UTC 2009
Arabidopsis MSI1 is required for negative regulation of the response to drought stress.
Molecular plant
Alexandre C,Möller-Steinbach Y,Schönrock N,Gruissem W,Hennig L
A-11122 was used in ChIP assay to report that MSI1 can bind to the chromatin of the drought-inducible downstream target RD20 and suggest a new role for MSI1 in the negative regulation of the Arabidopsis drought-stress response.
Wed Jul 01 00:00:00 UTC 2009
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint.
Nature genetics
Owusu-Ansah E,Yavari A,Mandal S,Banerjee U
A-11122 was used in immunohistochemistry to study the control of the G1-S cell cycle checkpoint due to distinct mitochondrial retrograde signals
Sat Mar 01 00:00:00 UTC 2008
RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation.
Nature cell biology
Nakaya Y,Sukowati EW,Wu Y,Sheng G
A-11122 was used in immunohistochemistry to study the epithelial-mesenchymal transition during gastrulation
Tue Jul 01 00:00:00 UTC 2008
Activation of Notch-mediated protective signaling in the myocardium.
Circulation research
Gude NA,Emmanuel G,Wu W,Cottage CT,Fischer K,Quijada P,Muraski JA,Alvarez R,Rubio M,Schaefer E,Sussman MA
A-11122 was used in Immunoprecipitation to suggest a positive survival feedback mechanism between Notch and Akt signaling in adult myocardium following injury.
Fri May 09 00:00:00 UTC 2008
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
The Journal of clinical investigation
Schessl J,Zou Y,McGrath MJ,Cowling BS,Maiti B,Chin SS,Sewry C,Battini R,Hu Y,Cottle DL,Rosenblatt M,Spruce L,Ganguly A,Kirschner J,Judkins AR,Golden JA,Goebel HH,Muntoni F,Flanigan KM,Mitchell CA,Bönnemann CG
A-11122 was used in immunocytochemistry to identify FHL1 as a factor that contributes to reducing body myopathy
Sat Mar 01 00:00:00 UTC 2008
Erythropoietin deficiency decreases vascular stability in mice.
The Journal of clinical investigation
Chen J,Connor KM,Aderman CM,Smith LE
A-11122 was used in immunohistochemistry - frozen section to assess the effects of erythropoietin on angiogenesis
Fri Feb 01 00:00:00 UTC 2008
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease.
Autophagy
Dagda RK,Zhu J,Kulich SM,Chu CT
A-11122 was used in western blot to assess regulation of autophagic and mitophagy cell stress due to mitochondrially localized ERK2 and implications in Parkinson's disease
Fri Aug 01 00:00:00 UTC 2008
Dietary genistein inhibits metastasis of human prostate cancer in mice.
Cancer research
Lakshman M,Xu L,Ananthanarayanan V,Cooper J,Takimoto CH,Helenowski I,Pelling JC,Bergan RC
A-11122 was used in immunohistochemistry to assess the anti-metastatic potential of genistein
Sat Mar 15 00:00:00 UTC 2008
Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase.
Molecular therapy : the journal of the American Society of Gene Therapy
Stachler MD,Chen I,Ting AY,Bartlett JS
A-11122 was used in immunohistochemistry - frozen section to study site-specific modification of AAV vector particles with targeting ligands and biophysical probes using biotin ligase
Fri Aug 01 00:00:00 UTC 2008
Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms.
Cell death and differentiation
Valentijn AJ,Upton JP,Bates N,Gilmore AP
A-11122 was used in western blot to elucidate how Bax is targeted to the mitochondrial membrane
Fri Aug 01 00:00:00 UTC 2008
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
The Journal of cell biology
Narendra D,Tanaka A,Suen DF,Youle RJ
A-11122 was used in western blot to report that Parkin promotes autophagy of damaged mitochondria
Mon Dec 01 00:00:00 UTC 2008
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.
The Journal of cell biology
Axe EL,Walker SA,Manifava M,Chandra P,Roderick HL,Habermann A,Griffiths G,Ktistakis NT
A-11122 was used in immunocytochemistry and western blot to study membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum during autophagosome formation
Mon Aug 25 00:00:00 UTC 2008
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.
The Journal of cell biology
Kowanetz M,Lönn P,Vanlandewijck M,Kowanetz K,Heldin CH,Moustakas A
A-11122 was used in immunocytochemistry and western blot to identify the salt-inducible kinase as an inducible gene target of TGFbeta/Smad signaling
Mon Aug 25 00:00:00 UTC 2008
SNARE protein mimicry by an intracellular bacterium.
PLoS pathogens
Delevoye C,Nilges M,Dehoux P,Paumet F,Perrinet S,Dautry-Varsat A,Subtil A
A-11122 was used in immunocytochemistry to elucidate the function of the SNARE-like motifs of Chlamydia's IncA
Fri Mar 14 00:00:00 UTC 2008
Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii.
PLoS pathogens
Hu K
A-11122 was used in immunocytochemistry to investigate cytoskeletal biogenesis of Toxoplasma gondii
Tue Jan 01 00:00:00 UTC 2008
meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye.
Development (Cambridge, England)
Bessa J,Tavares MJ,Santos J,Kikuta H,Laplante M,Becker TS,Gómez-Skarmeta JL,Casares F
A-11122 was used in immunohistochemistry to test if members of the Meis gene family contribute to the early stages of zebrafish eye development
Sat Mar 01 00:00:00 UTC 2008
Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points.
Development (Cambridge, England)
Pittman AJ,Law MY,Chien CB
A-11122 was used in immunohistochemistry to test the role of axon-axon interactions in retinotectal development
Mon Sep 01 00:00:00 UTC 2008
Chip is required for posteclosion behavior in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hari P,Deshpande M,Sharma N,Rajadhyaksha N,Ramkumar N,Kimura K,Rodrigues V,Tole S
A-11122 was used in immunohistochemistry to investigate the role of Chip in posteclosion behavior
Wed Sep 10 00:00:00 UTC 2008
Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dhaka A,Earley TJ,Watson J,Patapoutian A
A-11122 was used in immunohistochemistry to visualize cold spots by studying TRPM8-expressing sensory neurons and their projections
Wed Jan 16 00:00:00 UTC 2008
Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nakamura K,Nemani VM,Wallender EK,Kaehlcke K,Ott M,Edwards RH
A-11122 was used in western blot to describe FRET-based reporters to study conformational changes of alpha-synuclein
Wed Nov 19 00:00:00 UTC 2008
Differential dissociation of G protein heterotrimers.
The Journal of physiology
Digby GJ,Sethi PR,Lambert NA
A-11122 was used in immunocytochemistry to study the differential dissociation of GIRK channels
Tue Jul 15 00:00:00 UTC 2008
Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts.
Stem cells (Dayton, Ohio)
Grauss RW,van Tuyn J,Steendijk P,Winter EM,Pijnappels DA,Hogers B,Gittenberger-De Groot AC,van der Geest R,van der Laarse A,de Vries AA,Schalij MJ,Atsma DE
A-11122 was used in immunocytochemistry to test if myocardin expression stimulates human mesenchymal stem cells to acquire a cardiomyogenic phenotype
Tue Apr 01 00:00:00 UTC 2008
Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Qin K,Sethi PR,Lambert NA
A-11122 was used in blocking or activating experiment to assess the stability of alpha(2A)-adrenoreceptors and G protein complexes
Fri Aug 01 00:00:00 UTC 2008
Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy.
The American journal of pathology
Wallace GQ,Lapidos KA,Kenik JS,McNally EM
A-11122 was used in immunohistochemistry (frozen) immunofluorescence to examine the capacity of single injections of adult muscle mononuclear cells to provide long-term benefit for muscular dystrophy in delta-sarcoglycan-null dystrophic immunocompetent mice.
Mon Sep 01 00:00:00 UTC 2008
GFP reporter mice for the retinoblastoma-related cell cycle regulator p107.
Cell cycle (Georgetown, Tex.)
Burkhart DL,Viatour P,Ho VM,Sage J
A-11122 was used in immunohistochemistry - frozen section and immunohistochemistry - paraffin section to ascertain the role of p107 using transgenic mice
Fri Aug 15 00:00:00 UTC 2008
Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons.
Neuroscience
Arguello AA,Harburg GC,Schonborn JR,Mandyam CD,Yamaguchi M,Eisch AJ
A-11122 was used in immunohistochemistry - paraffin section to study how morphine regulates progenitor cell cycle, cell death, and immature subgranular zone neurons
Tue Nov 11 00:00:00 UTC 2008
Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondii.
Infection and immunity
Pollard AM,Onatolu KN,Hiller L,Haldar K,Knoll LJ
A-11122 was used in immunocytochemistry to characterize the expression of and host immune responses to SUSA1 from Toxoplasma gondii
Tue Jan 01 00:00:00 UTC 2008
Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury.
Journal of the Association for Research in Otolaryngology : JARO
Lang H,Schulte BA,Goddard JC,Hedrick M,Schulte JB,Wei L,Schmiedt RA
A-11122 was used in immunohistochemistry - paraffin section to study the survival and differentiation of embryonic stem cells introduced into the inner ear of gerbils
Sun Jun 01 00:00:00 UTC 2008
Pineal gland expression of the transcription factor Egr-1 is restricted to a population of glia that are distinct from nestin-immunoreactive cells.
Journal of molecular histology
Man PS,Carter DA
A-11122 was used in immunohistochemistry to observe the cellular expression pattern of Egr-1 in the adult rat pineal
Fri Feb 01 00:00:00 UTC 2008
Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice.
Journal of neuroscience methods
Basu K,Gravel C,Tomioka R,Kaneko T,Tamamaki N,Sík A
A-11122 was used in immunocytochemistry to characterize a novel process for selectively labeling inhibitory and excitatory neurons in the cerebral cortex of mice
Fri May 30 00:00:00 UTC 2008
Assessment of optimal virus-mediated growth factor gene delivery for human cutaneous wound healing enhancement.
The Journal of investigative dermatology
Escámez MJ,Carretero M,García M,Martínez-Santamaría L,Mirones I,Duarte B,Holguín A,García E,García V,Meana A,Jorcano JL,Larcher F,Del Río M
A-11122 was used in Immunohistochemistry to promote skin wound healing.
Sun Jun 01 00:00:00 UTC 2008
Drosophila retinal pigment cell death is regulated in a position-dependent manner by a cell memory gene.
The International journal of developmental biology
Dos-Santos N,Rubin T,Chalvet F,Gandille P,Cremazy F,Leroy J,Boissonneau E,Théodore L
A-11122 was used in Immunohistochemistry to support a model whereby death of IOCs on the oblique sides of ommatidiae requires Trl-dependent reduction of a survival signal, or an increase of a death signal, emanating from cone cells.
Thu Apr 03 00:00:00 UTC 2008
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2.
PLoS genetics
Pereira CF,Terranova R,Ryan NK,Santos J,Morris KJ,Cui W,Merkenschlager M,Fisher AG
A-11122 was used in flow cytometry and immunocytochemistry to study the conversion of human B-lymphocytes to a multipotent state
Fri Sep 05 00:00:00 UTC 2008
Telomeric position effect--a third silencing mechanism in eukaryotes.
PloS one
Doheny JG,Mottus R,Grigliatti TA
A-11122 was used in ChIP assay to elucidate the contribution of the telomeric position effect to gene silencing
Thu Jan 29 00:00:00 UTC 2009
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.
Development (Cambridge, England)
Nishi Y,Rogers E,Robertson SM,Lin R
A-11122 was used in Immunohistochemistry to provide a mechanism by which MEX-5 and MEX-6 function is temporally regulated during the crucial oocyte-to-embryo transition.
Fri Feb 01 00:00:00 UTC 2008
Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3.
Nature
Hart DO,Raha T,Lawson ND,Green MR
A-11122 was used in immunohistochemistry to characterize Trf3-depleted zebrafish
Thu Dec 13 00:00:00 UTC 2007
An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells.
Nature
Teh OK,Moore I
A-11122 was used in western blot to study selective endocytosis and an ARF-GEF acting at the Golgi in polarized plant cells
Thu Jul 26 00:00:00 UTC 2007
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4.
Nature immunology
Ménager MM,Ménasché G,Romao M,Knapnougel P,Ho CH,Garfa M,Raposo G,Feldmann J,Fischer A,de Saint Basile G
A-11122 was used in immunocytochemistry and western blot to investigate the roles of Rab27a and hMunc13-4 in the release of cytotoxic granules by effector cytotoxic T lymphocytes
Thu Mar 01 00:00:00 UTC 2007
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Nature immunology
Zhao T,Yang L,Sun Q,Arguello M,Ballard DW,Hiscott J,Lin R
A-11122 was used in western blot to report that NEMO contributes to RIG-I activation in response to viruses
Fri Jun 01 00:00:00 UTC 2007
N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.
Nature cell biology
Chen T,Muratore TL,Schaner-Tooley CE,Shabanowitz J,Hunt DF,Macara IG
A-11122 was used in immunocytochemistry to investigate the consequences of regulator of chromatin condensation 1 methylation
Tue May 01 00:00:00 UTC 2007
Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.
Circulation research
Otsuka G,Stempien-Otero A,Frutkin AD,Dichek DA
A-11122 was used in immunohistochemistry to elucidate how TGF-beta(1) induces substantial cell migration
Fri May 11 00:00:00 UTC 2007
Dlx transcription factors promote migration through repression of axon and dendrite growth.
Neuron
Cobos I,Borello U,Rubenstein JL
A-11122 was used in immunohistochemistry - frozen section to assess promotion of migration through repression of dendrite and axon growth by Dlx transcription factors
Thu Jun 21 00:00:00 UTC 2007
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2.
Neuron
Arenkiel BR,Peca J,Davison IG,Feliciano C,Deisseroth K,Augustine GJ,Ehlers MD,Feng G
A-11122 was used in immunohistochemistry - frozen section to use transgenic mice that express a ChR2-YFP fusion protein in the central nervous system for in vivo activation and mapping of neural circuits
Thu Apr 19 00:00:00 UTC 2007
Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies.
Developmental cell
Delanoue R,Herpers B,Soetaert J,Davis I,Rabouille C
A-11122 was used in immunohistochemistry to study the switch of Dynein from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies in Drosophila Squid/hnRNP
Mon Oct 01 00:00:00 UTC 2007
Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling.
Proceedings of the National Academy of Sciences of the United States of America
Tuluc P,Kern G,Obermair GJ,Flucher BE
A-11122 was used in immunocytochemistry to study an indication of an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling by computer modeling of siRNA knockdown
Tue Jun 26 00:00:00 UTC 2007
Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis.
Annals of neurology
Gerdoni E,Gallo B,Casazza S,Musio S,Bonanni I,Pedemonte E,Mantegazza R,Frassoni F,Mancardi G,Pedotti R,Uccelli A
A-11122 was used in immunocytochemistry to assess the ability of mesenchymal stem cells to cure experimental autoimmune encephalomyelitis
Thu Mar 01 00:00:00 UTC 2007
An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells.
Breast cancer research : BCR
Duss S,André S,Nicoulaz AL,Fiche M,Bonnefoi H,Brisken C,Iggo RD
A-11122 was used in immunocytochemistry to develop an estrogen receptor-alpha-positive model of breast cancer using human mammary epithelial cells
Fri Sep 14 00:00:00 UTC 2007
v-SNARE cellubrevin is required for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells.
The Journal of cell biology
Fields IC,Shteyn E,Pypaert M,Proux-Gillardeaux V,Kang RS,Galli T,Fölsch H
A-11122 was used to assess requirement for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells by v-SNARE cellubrevin
Mon May 07 00:00:00 UTC 2007
Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.
Journal of medicinal chemistry
Stebbins JL,Zhang Z,Chen J,Wu B,Emdadi A,Williams ME,Cashman J,Pellecchia M
A-11122 was used in immunocytochemistry to identify chemical inhibitors of FKBP12
Thu Dec 27 00:00:00 UTC 2007
Laser-induced fluorescence detector for capillary-based isoelectric immunoblot assay.
Analytical chemistry
Knittle JE,Roach D,Horn PB,Voss KO
A-11122 was used to utilize a whole-capillary, multicolor laser-induced fluorescence scanner for microfluidic protein analysis to spatially resolve and quantify proteins
Sat Dec 15 00:00:00 UTC 2007
The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis.
Development (Cambridge, England)
Petrella LN,Smith-Leiker T,Cooley L
A-11122 was used in immunohistochemistry to study proteins that contribute to Drosophila oogenesis
Thu Feb 01 00:00:00 UTC 2007
Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation.
Development (Cambridge, England)
Guo Q,Li JY
A-11122 was used in immunohistochemistry to ascertain the requirement for Fgf8b in mice
Fri Jun 01 00:00:00 UTC 2007
Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hoser M,Baader SL,Bösl MR,Ihmer A,Wegner M,Sock E
A-11122 was used in immunohistochemistry to study the effect of prolonged glial expression of Sox4 in the CNS on the cerebral architecture and ataxia
Wed May 16 00:00:00 UTC 2007
Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Takashima Y,Daniels RL,Knowlton W,Teng J,Liman ER,McKemy DD
A-11122 was used in immunohistochemistry - frozen section to elucidate how TRPM8 contributes to cold signaling
Wed Dec 19 00:00:00 UTC 2007
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lagace DC,Whitman MC,Noonan MA,Ables JL,DeCarolis NA,Arguello AA,Donovan MH,Fischer SJ,Farnbauch LA,Beech RD,DiLeone RJ,Greer CA,Mandyam CD,Eisch AJ
A-11122 was used in immunohistochemistry to describe a nestin-CreER(T2)/R26R-yellow fluorescent protein mouse that inducibly labels nestin-expressing stem cells and their progeny in the adult subventricular zone and subgranular zone
Wed Nov 14 00:00:00 UTC 2007
Synaptic heterogeneity between mouse paracapsular intercalated neurons of the amygdala.
The Journal of physiology
Geracitano R,Kaufmann WA,Szabo G,Ferraguti F,Capogna M
A-11122 was used in immunohistochemistry - free floating to study GABAergic medial paracapsular intercalated neurons of amygdala
Thu Nov 15 00:00:00 UTC 2007
Limitations of green fluorescent protein as a cell lineage marker.
Stem cells (Dayton, Ohio)
Swenson ES,Price JG,Brazelton T,Krause DS
A-11122 was used in immunohistochemistry to compare three transgenic mouse strains in which GFP is considered ubiquitously expressed
Mon Oct 01 00:00:00 UTC 2007
Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction.
American journal of physiology. Heart and circulatory physiology
Grauss RW,Winter EM,van Tuyn J,Pijnappels DA,Steijn RV,Hogers B,van der Geest RJ,de Vries AA,Steendijk P,van der Laarse A,Gittenberger-de Groot AC,Schalij MJ,Atsma DE
A-11122 was used in immunocytochemistry and immunohistochemistry - paraffin section to examine the behavior of human mesenchymal stem cells from ischemic heart disease patients in an immune-compromised mouse acute myocardial infarction model
Mon Oct 01 00:00:00 UTC 2007
p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.
FEBS letters
Zuluaga S,Gutiérrez-Uzquiza A,Bragado P,Alvarez-Barrientos A,Benito M,Nebreda AR,Porras A
A-11122 was used in western blot to examine the cross-talk between p38alpha and Rac-1
Tue Aug 07 00:00:00 UTC 2007
Cholesterol controls lipid endocytosis through Rab11.
Molecular biology of the cell
Takahashi M,Murate M,Fukuda M,Sato SB,Ohta A,Kobayashi T
A-11122 was used in immunoprecipitation to measure the endocytosis of several lipid probes in subconfluent and confluent Chinese hamster ovary cells
Sun Jul 01 00:00:00 UTC 2007
Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.
Molecular biology of the cell
Boca M,D'Amato L,Distefano G,Polishchuk RS,Germino GG,Boletta A
A-11122 was used in western blot to investigate the functions of polycystin-1 in epithelial cells
Mon Oct 01 00:00:00 UTC 2007
Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.
Molecular biology of the cell
Lerdrup M,Bruun S,Grandal MV,Roepstorff K,Kristensen MM,Hommelgaard AM,van Deurs B
A-11122 was used in immunocytochemistry to investigate ErbB2 cleavage and endocytic trafficking
Sat Sep 01 00:00:00 UTC 2007
Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal.
Developmental neurobiology
Hernández PP,Olivari FA,Sarrazin AF,Sandoval PC,Allende ML
A-11122 was used in immunohistochemistry to visualize the loss and reappearance of lateral line hair cells induced in zebrafish larvae treated with copper sulfate
Sun Apr 01 00:00:00 UTC 2007
Characterization of progenitor domains in the developing mouse thalamus.
The Journal of comparative neurology
Vue TY,Aaker J,Taniguchi A,Kazemzadeh C,Skidmore JM,Martin DM,Martin JF,Treier M,Nakagawa Y
A-11122 was used in immunohistochemistry to characterize progenitor cells in the developing mouse thalamus.
Thu Nov 01 00:00:00 UTC 2007
Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain.
Journal of neuroscience methods
Franciosi S,De Gasperi R,Dickstein DL,English DF,Rocher AB,Janssen WG,Christoffel D,Sosa MA,Hof PR,Buxbaum JD,Elder GA
A-11122 was used in immunohistochemistry - free floating to assess the allowing of collagen IV immunostaining of blood vessels in adult mouse brain by pepsin pretreatment
Fri Jun 15 00:00:00 UTC 2007
Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells.
Genes to cells : devoted to molecular & cellular mechanisms
Kobayakawa S,Miike K,Nakao M,Abe K
A-11122 was used in immunocytochemistry to develop a technique to observe global DNA methylation in living mouse embryonic stem cells
Sun Apr 01 00:00:00 UTC 2007
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
The EMBO journal
Willard MD,Willard FS,Li X,Cappell SD,Snider WD,Siderovski DP
A-11122 was used in Immunohistochemistry to suggest that RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation.
Wed Apr 18 00:00:00 UTC 2007
Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel.
Neuron
Lerchner W,Xiao C,Nashmi R,Slimko EM,van Trigt L,Lester HA,Anderson DJ
A-11122 was used in Immunohistochemistry to assess amphetamine-induced rotational behavior in mice.
Thu Apr 05 00:00:00 UTC 2007
Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication.
The Journal of biological chemistry
Ao Z,Huang G,Yao H,Xu Z,Labine M,Cochrane AW,Yao X
A-11122 was used in immunoprecipitation and western blot to report that HIV-1 integrase specifically interacts with Imp7
Fri May 04 00:00:00 UTC 2007
Evidence that stem cells reside in the adult Drosophila midgut epithelium.
Nature
Micchelli CA,Perrimon N
A-11122 was used in immunohistochemistry to learn about adult Drosophila midgut epithelium and evidence of residing stem cells
Thu Jan 26 00:00:00 UTC 2006
A hybrid vector for ligand-directed tumor targeting and molecular imaging.
Cell
Hajitou A,Trepel M,Lilley CE,Soghomonyan S,Alauddin MM,Marini FC,Restel BH,Ozawa MG,Moya CA,Rangel R,Sun Y,Zaoui K,Schmidt M,von Kalle C,Weitzman MD,Gelovani JG,Pasqualini R,Arap W
A-11122 was used in immunohistochemistry - paraffin section to combine an adeno-associated virus and single-stranded bacteriophage and characterize this hybrid virus
Fri Apr 21 00:00:00 UTC 2006
Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development.
Nature neuroscience
Komai S,Licznerski P,Cetin A,Waters J,Denk W,Brecht M,Osten P
A-11122 was used in immunohistochemistry to assess the developmental role of somatodendritic excitability
Fri Sep 01 00:00:00 UTC 2006
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.
Blood
Willey S,Ayuso-Sacido A,Zhang H,Fraser ST,Sahr KE,Adlam MJ,Kyba M,Daley GQ,Keller G,Baron MH
A-11122 was used in immunocytochemistry to investigate the role of homeobox gene Mix-like in mesoderm development
Sat Apr 15 00:00:00 UTC 2006
Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment.
Proceedings of the National Academy of Sciences of the United States of America
Kulesa PM,Kasemeier-Kulesa JC,Teddy JM,Margaryan NV,Seftor EA,Seftor RE,Hendrix MJ
A-11122 was used in immunohistochemistry to analyze reprogramming to assume a neural crest cell-like phenotype in an embryonic microenvironment in metastatic melanoma cells
Tue Mar 07 00:00:00 UTC 2006
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America
Liao G,Tao Q,Kofron M,Chen JS,Schloemer A,Davis RJ,Hsieh JC,Wylie C,Heasman J,Kuan CY
A-11122 was used in immunoprecipitation and western blot to study prevention of nuclear beta-catenin accumulation and regulation of axis formation in Xenopus embryos by Jun NH2-terminal kinase (JNK)
Tue Oct 31 00:00:00 UTC 2006
Glycine receptors regulate interneuron differentiation during spinal network development.
Proceedings of the National Academy of Sciences of the United States of America
McDearmid JR,Liao M,Drapeau P
A-11122 was used in immunohistochemistry to perturb glycinergic transmission from the onset of zebrafish development and examine its impact on the formation of the locomotor circuitry
Tue Jun 20 00:00:00 UTC 2006
Compartmentalized signaling of Ras in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America
Onken B,Wiener H,Philips MR,Chang EC
A-11122 was used in western blot to study Ras and compartmentalized signaling in fission yeast
Tue Jun 13 00:00:00 UTC 2006
Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Mukouyama YS,Deneen B,Lukaszewicz A,Novitch BG,Wichterle H,Jessell TM,Anderson DJ
A-11122 was used in immunohistochemistry to test if ventricular zone progenitors behave as stem cells in vivo
Tue Jan 31 00:00:00 UTC 2006
The Salmonella effector protein PipB2 is a linker for kinesin-1.
Proceedings of the National Academy of Sciences of the United States of America
Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S
A-11122 was used in immunoprecipitation and western blot to study a linker for kinesin-1 called salmonella effector protein PipB2
Tue Sep 05 00:00:00 UTC 2006
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina.
Proceedings of the National Academy of Sciences of the United States of America
Livne-Bar I,Pacal M,Cheung MC,Hankin M,Trogadis J,Chen D,Dorval KM,Bremner R
A-11122 was used in immunohistochemistry - frozen section to elucidate how Chx10 contributes to the development of retinal progenitor cells
Tue Mar 28 00:00:00 UTC 2006
The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity.
Proceedings of the National Academy of Sciences of the United States of America
Siddall NA,McLaughlin EA,Marriner NL,Hime GR
A-11122 was used in immunohistochemistry to report a cell-autonomous requirement for Msi family proteins in regulating stem cell differentiation in the Drosophila testis
Tue May 30 00:00:00 UTC 2006
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America
Rowe DC,McGettrick AF,Latz E,Monks BG,Gay NJ,Yamamoto M,Akira S,O'Neill LA,Fitzgerald KA,Golenbock DT
A-11122 was used in immunoprecipitation and western blot to study the need for Toll-like receptor 4 signal transduction by myristoylation of TRIF-related adaptor molecule
Tue Apr 18 00:00:00 UTC 2006
A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking.
Proceedings of the National Academy of Sciences of the United States of America
Awai K,Xu C,Tamot B,Benning C
A-11122 was used in western blot to characterize lipid trafficking and a phosphatidic acid-binding protein of the chloroplast inner envelope membrane
Tue Jul 11 00:00:00 UTC 2006
Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America
Covassin LD,Villefranc JA,Kacergis MC,Weinstein BM,Lawson ND
A-11122 was used in immunohistochemistry to discuss how vascular endothelial growth factor a signaling contributes to the formation of arteries and veins
Tue Apr 25 00:00:00 UTC 2006
Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate.
Proceedings of the National Academy of Sciences of the United States of America
Liu L,Cundiff P,Abel G,Wang Y,Faigle R,Sakagami H,Xu M,Xia Z
A-11122 was used in immunocytochemistry and western blot to study ERK5 signaling during brain development
Tue Jun 20 00:00:00 UTC 2006
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America
Lee KW,Kim Y,Kim AM,Helmin K,Nairn AC,Greengard P
A-11122 was used in immunohistochemistry - frozen section to study the formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens by cocaine-induced dendritic spine formation
Tue Feb 28 00:00:00 UTC 2006
Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly.
The Journal of cell biology
Chen X,Macara IG
A-11122 was used in immunocytochemistry and immunoprecipitation to assess inhibition of LIM kinase 2 to regulate tight junction assembly and cofilin phosphorylation by Par-3
Mon Feb 27 00:00:00 UTC 2006
A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling.
The Journal of cell biology
Dantuma NP,Groothuis TA,Salomons FA,Neefjes J
A-11122 was used in western blot to study the coupling of chromatin remodeling to proteasomal activity by a dynamic ubiquitin equilibrium
Mon Apr 10 00:00:00 UTC 2006
A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells.
The Journal of cell biology
Cooke BM,Buckingham DW,Glenister FK,Fernandez KM,Bannister LH,Marti M,Mohandas N,Coppel RL
A-11122 was used in immunocytochemistry to study the expression of the major malaria virulence antigen on the surface of infected red blood cells that requires a Maurer's cleft-associated protein
Mon Mar 13 00:00:00 UTC 2006
Asynchronous nuclear division cycles in multinucleated cells.
The Journal of cell biology
Gladfelter AS,Hungerbuehler AK,Philippsen P
A-11122 was used in immunocytochemistry to elucidate multinucleated cells and asynchronous nuclear division cycles
Mon Jan 30 00:00:00 UTC 2006
Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pla R,Borrell V,Flames N,Marín O
A-11122 was used in immunohistochemistry - frozen section to analyze the mechanisms underlying the acquisition of laminar locations by cortical interneurons
Wed Jun 28 00:00:00 UTC 2006
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Journal of cell science
Lerdrup M,Hommelgaard AM,Grandal M,van Deurs B
A-11122 was used in immunocytochemistry to investigate ErbB2 internalization
Sun Jan 01 00:00:00 UTC 2006
Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.
Journal of cell science
Martín-Villar E,Megías D,Castel S,Yurrita MM,Vilaró S,Quintanilla M
A-11122 was used in immunocytochemistry to elucidate the role of podoplanin in cell migration or invasiveness
Wed Nov 01 00:00:00 UTC 2006
Generation and characterization of novel tetracycline-inducible pancreatic transcription factor-expressing murine embryonic stem cell lines.
Stem cells and development
Vincent R,Treff N,Budde M,Kastenberg Z,Odorico J
A-11122 was used in immunohistochemistry - frozen section to investigate transcription factors that contribute to pancreatic development
Fri Dec 01 00:00:00 UTC 2006
CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis.
Biochemistry
Painter RG,Valentine VG,Lanson NA,Leidal K,Zhang Q,Lombard G,Thompson C,Viswanathan A,Nauseef WM,Wang G,Wang G
A-11122 was used in immunoprecipitation to test if cystic fibrosis neutrophils are deficient in chlorination of bacterial components due to limited phagasomal chloride
Tue Aug 29 00:00:00 UTC 2006
C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations.
Developmental biology
Hudson ML,Kinnunen T,Cinar HN,Chisholm AD
A-11122 was used in immunohistochemistry study how KAL-1 promotes ventral neuroblast migration prior to epidermal enclosure
Thu Jun 15 00:00:00 UTC 2006
Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation.
Journal of chemical neuroanatomy
Sukhotinsky I,Reiner K,Govrin-Lippmann R,Belenky M,Lu J,Hopkins DA,Saper CB,Devor M
A-11122 was used in immunohistochemistry to investigate the mesopontine tegmental anesthesia area
Fri Dec 01 00:00:00 UTC 2006
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.
Genesis (New York, N.Y. : 2000)
Beard C,Hochedlinger K,Plath K,Wutz A,Jaenisch R
A-11122 was used in immunohistochemistry - paraffin section to describe a technique to generate mice with transgenes efficiently targeted to a defined site
Sun Jan 01 00:00:00 UTC 2006
The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing.
The Journal of biological chemistry
Léonard R,Rendic D,Rabouille C,Wilson IB,Préat T,Altmann F
A-11122 was used in immunocytochemistry to study encoding of an N-acetylglucosaminidase involved in N-glycan processing in the Drosophila fused lobes gene
Fri Feb 24 00:00:00 UTC 2006
PIN-G--a novel reporter for imaging and defining the effects of trafficking signals in membrane proteins.
BMC biotechnology
McKeown L,Robinson P,Greenwood SM,Hu W,Jones OT
A-11122 was used in immunocytochemistry to discuss methods to identify protein trafficking signals
Wed Mar 08 00:00:00 UTC 2006
Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.
The Journal of biological chemistry
Xiao J,Dai R,Negyessy L,Bergson C
A-11122 was used in immunocytochemistry to investigate the role of calcyon in clathrin-mediated endocytosis
Fri Jun 02 00:00:00 UTC 2006
Cellular uptake of exogenous human PDCD5 protein.
The Journal of biological chemistry
Wang Y,Li D,Fan H,Tian L,Zhong Y,Zhang Y,Yuan L,Jin C,Yin C,Ma D
A-11122 was used in immunocytochemistry to study exogenous human PDCD5 protein and cellular uptake
Fri Aug 25 00:00:00 UTC 2006
Hemicentin assembly in the extracellular matrix is mediated by distinct structural modules.
The Journal of biological chemistry
Dong C,Muriel JM,Ramirez S,Hutter H,Hedgecock EM,Breydo L,Baskakov IV,Vogel BE
A-11122 was used in western blot to determine which hemicentin domains are critical for function and assembly
Fri Aug 18 00:00:00 UTC 2006
Blockade of NFAT activation by the second calcineurin binding site.
The Journal of biological chemistry
Martínez-Martínez S,Rodríguez A,López-Maderuelo MD,Ortega-Pérez I,Vázquez J,Redondo JM
A-11122 was used in western blot to assess the second calcineurin binding site by blockade of NFAT activation
Fri Mar 10 00:00:00 UTC 2006
Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies.
The Journal of biological chemistry
Jang LT,Buu LM,Lee FJ
A-11122 was used in immunocytochemistry to study determinants of Rbp1p localization called P-bodies in specific cytoplasmic mRNA-processing foci
Fri Sep 29 00:00:00 UTC 2006
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.
The Journal of biological chemistry
Takahashi Y,Dominici M,Swift J,Nagy C,Ihle JN
A-11122 was used in immunohistochemistry - paraffin section to study the rescue of placental defect in SOCS3-deficient mice due to trophoblast stem cells
Fri Apr 28 00:00:00 UTC 2006
Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.
The Journal of biological chemistry
Pérez-Victoria FJ,Sánchez-Cañete MP,Castanys S,Gamarro F
A-11122 was used in western blot to study the requirement of L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites due to phospholipid translocation and miltefosine potency
Fri Aug 18 00:00:00 UTC 2006
Temporal and spatial control of transgene expression using laser induction of the hsp70 promoter.
BMC developmental biology
Ramos DM,Kamal F,Wimmer EA,Cartwright AN,Monteiro A
A-11122 was used in immunohistochemistry to discuss temporal and spatial regulation of transgene expression in non-model organisms
Mon Nov 20 00:00:00 UTC 2006
Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb.
Developmental biology
Kim J,Lauderdale JD
A-11122 was used in Western Blot to demonstrate a role for Pax6DeltaPD in eye development, which appears to be different than that ascribed to either canonical Pax6 or Pax6(5a).
Sat Apr 15 00:00:00 UTC 2006
Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells.
The Journal of biological chemistry
Jiang Y,Oliver P,Davies KE,Platt N
A-11122 was used in western blot to analyze and identify a novel class A scavenger receptor that is expressed by populations of epithelial cells called murine SCARA5
Fri Apr 28 00:00:00 UTC 2006
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
The Journal of biological chemistry
Kuwahara T,Koyama A,Gengyo-Ando K,Masuda M,Kowa H,Tsunoda M,Mitani S,Iwatsubo T
A-11122 was used in immunohistochemistry - paraffin section to develop and characterize Caenorhabditis elegans that overexpresses wild-type or familial Parkinson mutant human alpha-synuclein in dopamine neurons
Fri Jan 06 00:00:00 UTC 2006
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.
The Journal of biological chemistry
Miller S,Sparacio S,Bartenschlager R
A-11122 was used in immunocytochemistry and western blot to characterize the Dengue virus type 2 non-structural protein 4B and its membrane topology and subcellular localization
Fri Mar 31 00:00:00 UTC 2006
Stem cell division is regulated by the microRNA pathway.
Nature
Hatfield SD,Shcherbata HR,Fischer KA,Nakahara K,Carthew RW,Ruohola-Baker H
A-11122 was used in immunohistochemistry to study the regulation by the microRNA pathway due to stem cell division
Thu Jun 16 00:00:00 UTC 2005
GPCR signaling is required for blood-brain barrier formation in drosophila.
Cell
Schwabe T,Bainton RJ,Fetter RD,Heberlein U,Gaul U
A-11122 was used in immunohistochemistry to study the requirement for blood-brain barrier formation in drosophila by GPCR signaling
Fri Oct 07 00:00:00 UTC 2005
Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.
Nature methods
Sugiyama Y,Kawabata I,Sobue K,Okabe S
A-11122 was used in immunocytochemistry to develop a technique to estimate the amounts of proteins in macromolecular complexes
Thu Sep 01 00:00:00 UTC 2005
Glutamate receptor dynamics organizing synapse formation in vivo.
Nature neuroscience
Rasse TM,Fouquet W,Schmid A,Kittel RJ,Mertel S,Sigrist CB,Schmidt M,Guzman A,Merino C,Qin G,Quentin C,Madeo FF,Heckmann M,Sigrist SJ
A-11122 was used in immunohistochemistry to observe the glutamate receptor subunit in the neuromuscular junctions of Drosophila melanogaster larvae
Fri Jul 01 00:00:00 UTC 2005
Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line.
Neuron
Grant KA,Raible DW,Piotrowski T
A-11122 was used in immunohistochemistry to identify a role for glia in regulating sensory hair cell precursors
Thu Jan 06 00:00:00 UTC 2005
Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons.
Neuron
Karpova AY,Tervo DG,Gray NW,Svoboda K
A-11122 was used in immunohistochemistry to analyze synaptic transmission in genetically targeted neurons by rapid and reversible chemical inactivation
Thu Dec 08 00:00:00 UTC 2005
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.
Proceedings of the National Academy of Sciences of the United States of America
Li X,Gutierrez DV,Hanson MG,Han J,Mark MD,Chiel H,Hegemann P,Landmesser LT,Herlitze S
A-11122 was used in immunocytochemistry to develop tools to control neuronal excitability and modulate synaptic transmission
Tue Dec 06 00:00:00 UTC 2005
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Goldstein AY,Jan YN,Luo L
A-11122 was used in immunohistochemistry to report that Tumbleweed, Pavarotti, and their association are required for neuroblast proliferation in Drosophila
Tue Mar 08 00:00:00 UTC 2005
IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.
The Journal of cell biology
Sacco A,Doyonnas R,LaBarge MA,Hammer MM,Kraft P,Blau HM
A-11122 was used in immunohistochemistry - frozen section to propose that insulin-like growth factor I is sufficient to enhance the fusion of bone marrow-derived cells with adult skeletal muscle
Mon Nov 07 00:00:00 UTC 2005
Ubiquitous GFP expression in transgenic chickens using a lentiviral vector.
Development (Cambridge, England)
Chapman SC,Lawson A,Macarthur WC,Wiese RJ,Loechel RH,Burgos-Trinidad M,Wakefield JK,Ramabhadran R,Mauch TJ,Schoenwolf GC
A-11122 was used in immunohistochemistry - paraffin section to report the first ubiquitous green fluorescent protein expression in chicks using a lentiviral vector approach
Tue Mar 01 00:00:00 UTC 2005
aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development.
Development (Cambridge, England)
Chalmers AD,Pambos M,Mason J,Lang S,Wylie C,Papalopulu N
A-11122 was used in immunohistochemistry to determine the roles of Crumbs3, Lgl2, and apical aPKC in the polarization of frog blastomeres
Tue Mar 01 00:00:00 UTC 2005
Adult-born and preexisting olfactory granule neurons undergo distinct experience-dependent modifications of their olfactory responses in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Magavi SS,Mitchell BD,Szentirmai O,Carter BS,Macklis JD
A-11122 was used in immunocytochemistry to test if recently generated, adult-born neurons contribute to neural plasticity and learning
Wed Nov 16 00:00:00 UTC 2005
Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules in human hepatocytes.
Journal of virology
Salminen M,Airenne KJ,Rinnankoski R,Reimari J,Välilehto O,Rinne J,Suikkanen S,Kukkonen S,Ylä-Herttuala S,Kulomaa MS,Vihinen-Ranta M
A-11122 was used in immunocytochemistry to investigate the role of the cellular cytoskeleton in the cytoplasmic trafficking of autographa californica multicapsid nucleopolyhedrovirus particles toward the nucleus in human hepatic cells
Tue Mar 01 00:00:00 UTC 2005
In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions.
Stem cells (Dayton, Ohio)
Ishii G,Sangai T,Sugiyama K,Ito T,Hasebe T,Endoh Y,Magae J,Ochiai A
A-11122 was used in immunohistochemistry - paraffin section to study the recruitment into fibrotic lesions by in vivo characterization of bone marrow-derived fibroblasts
Sun May 01 00:00:00 UTC 2005
The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis.
Journal of cell science
Dawe HR,Farr H,Portman N,Shaw MK,Gull K
A-11122 was used in immunocytochemistry to identify PACRG as a gene that contributes to flagella regulation
Thu Dec 01 00:00:00 UTC 2005
Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane.
Journal of cell science
Ozeki S,Cheng J,Tauchi-Sato K,Hatano N,Taniguchi H,Fujimoto T
A-11122 was used in immunocytochemistry to propose that Rab18 regulates the lipid droplet-associated membrane
Wed Jun 15 00:00:00 UTC 2005
Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3).
The Biochemical journal
Swiercz R,Person MD,Bedford MT
A-11122 was used in immunoprecipitation and western blot to identify substrates for mammalian PRMT3
Tue Feb 15 00:00:00 UTC 2005
Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor control.
The Journal of comparative neurology
Sukhotinsky I,Hopkins DA,Lu J,Saper CB,Devor M
A-11122 was used in immunohistochemistry to investigate the effect of pentobarbital and GABA(A)-receptor administration to the mesopontine tegmental anesthesia area.
Mon Sep 05 00:00:00 UTC 2005
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.
The Journal of biological chemistry
Martin S,Driessen K,Nixon SJ,Zerial M,Parton RG
A-11122 was used in immunocytochemistry and western blot to analyze regulation of localized Rab18 to lipid droplets and the effects of lipolytic stimulation and inhibition of lipid droplet catabolism
Fri Dec 23 00:00:00 UTC 2005
Improved tagging strategy for protein identification in mammalian cells.
BMC genomics
Bialkowska A,Zhang XY,Reiser J
A-11122 was used in western blot to discuss a tagging strategy that enables full-length endogenous proteins to be expressed as green fluorescent fusion proteins from their authentic promoters in mammalian cells
Sun Sep 04 00:00:00 UTC 2005
Differential trafficking of GluR7 kainate receptor subunit splice variants.
The Journal of biological chemistry
Jaskolski F,Normand E,Mulle C,Coussen F
A-11122 was used in Immunoprecipitation to study the trafficking of GluR7 splice variants in cultured hippocampal neurons from wild-type and kainate receptor mutant mice.
Fri Jun 17 00:00:00 UTC 2005
Nanotubular highways for intercellular organelle transport.
Science (New York, N.Y.)
Rustom A,Saffrich R,Markovic I,Walther P,Gerdes HH
A-11122 was used in immunocytochemistry to determine intercellular organelle transport by nanotubular highways
Fri Feb 13 00:00:00 UTC 2004
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice.
Blood
Follenzi A,Battaglia M,Lombardo A,Annoni A,Roncarolo MG,Naldini L
A-11122 was used in immunohistochemistry to study the limits of transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice due to targeting lentiviral vector expression to hepatocytes
Sat May 15 00:00:00 UTC 2004
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors.
Proceedings of the National Academy of Sciences of the United States of America
Sekine-Aizawa Y,Huganir RL
A-11122 was used in immunocytochemistry to utilize alpha-bungarotoxin-binding-site-tagged receptors for imaging of receptor trafficking
Tue Dec 07 00:00:00 UTC 2004
The cohesion protein ORD is required for homologue bias during meiotic recombination.
The Journal of cell biology
Webber HA,Howard L,Bickel SE
A-11122 was used in immunohistochemistry to report that ORD activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers
Mon Mar 15 00:00:00 UTC 2004
Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.
The Journal of cell biology
Lechardeur D,Xu M,Lukacs GL
A-11122 was used in western blot to study apoptotic and dividing cells to view contrasting nuclear dynamics of the caspase-activated Dnase (CAD)
Mon Dec 06 00:00:00 UTC 2004
Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration.
The Journal of cell biology
McHugh B,Krause SA,Yu B,Deans AM,Heasman S,McLaughlin P,Heck MM
A-11122 was used in immunocytochemistry to investigate the role of IX-14/invadolysin in mitosis
Mon Nov 22 00:00:00 UTC 2004
An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Senut MC,Gulati-Leekha A,Goldman D
A-11122 was used in immunohistochemistry - frozen section to study the requirement for retinal expression during optic nerve regeneration by an element in the alpha1-tubulin promoter and not after eye injury in the adult zebrafish
Wed Sep 01 00:00:00 UTC 2004
Preservation of immunoreactivity and fine structure of adult C. elegans tissues using high-pressure freezing.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Rostaing P,Weimer RM,Jorgensen EM,Triller A,Bessereau JL
A-11122 was used in immunohistochemistry to describe a protocol to prepare C. elegans for immunoelectron microscopy studies.
Thu Jan 01 00:00:00 UTC 2004
Emergence of realistic retinal networks in culture promoted by the superior colliculus.
Developmental neuroscience
Colicos MA,Firth SI,Bosze J,Goldstein J,Feller MB
A-11122 was used in Immunocytochemistry-immunoflourescence to demonstrate that by culturing dissociated retinal neurons in the presence of cells from the superior colliculus (SC), retinal neurons form networks that are similar to those described in the intact retina.
Wed Jul 20 00:00:00 UTC 2005
Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter.
Developmental biology
Rowan S,Cepko CL
A-11122 was used in immunohistochemistry - frozen section to examine Chx10 regulation and function
Thu Jul 15 00:00:00 UTC 2004
The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system.
The Journal of biological chemistry
Angers A,Ramjaun AR,McPherson PS
A-11122 was used in immunocytochemistry to assess ubiquitination of endophilin and localization to the trans-Golgi network and endosomal system by the HECT domain ligase itch
Fri Mar 19 00:00:00 UTC 2004
Transient requirement for ganglion cells during assembly of retinal synaptic layers.
Development (Cambridge, England)
Kay JN,Roeser T,Mumm JS,Godinho L,Mrejeru A,Wong RO,Baier H
A-11122 was used in Immunohistochemistry to suggest that amacrines may guide IPL sublamination by providing stratification cues for other cell types.
Mon Mar 01 00:00:00 UTC 2004
Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana.
Nature
Más P,Kim WY,Somers DE,Kay SA
A-11122 was used in western blot to analyze the modulation of circadian function in Arabidopsis thaliana by targeted degradation of TOC1 by ZTL
Thu Dec 04 00:00:00 UTC 2003
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant.
Nature cell biology
Weimann JM,Johansson CB,Trejo A,Blau HM
A-11122 was used in immunohistochemistry - frozen section to demonstrate that bone-marrow-derived cells contribute to adult mouse Purkinje neurons through cell fusion
Sat Nov 01 00:00:00 UTC 2003
Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres.
Nature cell biology
Bailis JM,Bernard P,Antonelli R,Allshire RC,Forsburg SL
A-11122 was used in immunoprecipitation to elucidate the role of the role for Hsk1-Dfp1 complex
Mon Dec 01 00:00:00 UTC 2003
Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.
The Journal of cell biology
Pidoux AL,Richardson W,Allshire RC
A-11122 was used in immunoprecipitation to identify components involved in central core silencing and kinetochore assembly or structure of fission yeast
Mon Apr 28 00:00:00 UTC 2003
In vitro and in vivo gene delivery by recombinant baculoviruses.
Journal of virology
Tani H,Limn CK,Yap CC,Onishi M,Nozaki M,Nishimune Y,Okahashi N,Kitagawa Y,Watanabe R,Mochizuki R,Moriishi K,Matsuura Y
A-11122 was used in immunocytochemistry to study recombinant baculoviruses by in vivo and in vitro gene delivery
Mon Sep 01 00:00:00 UTC 2003
In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors.
Human gene therapy
De Palma M,Venneri MA,Naldini L
A-11122 was used in immunohistochemistry - frozen section to test a panel of vesicular stomatitis virus-pseudo typed lentiviral vectors engineered for endothelial cell-specific expression.
Sun Aug 10 00:00:00 UTC 2003
Cardiac-type EC-coupling in dysgenic myotubes restored with Ca2+ channel subunit isoforms alpha1C and alpha1D does not correlate with current density.
Biophysical journal
Kasielke N,Obermair GJ,Kugler G,Grabner M,Flucher BE
A-11122 was used in immunocytochemistry to study the restoration with Ca2+ channel subunit isoforms alpha1C and alpha1D that does not correlate with current density by cardiac-type EC-coupling in dysgenic myotubes
Sun Jun 01 00:00:00 UTC 2003
GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.
The Journal of biological chemistry
Luke MR,Kjer-Nielsen L,Brown DL,Stow JL,Gleeson PA
A-11122 was used in immunocytochemistry to study two new coiled-coil proteins, GCC88 and GCC185, that perform GRIP domain-mediated targeting to subcompartments of the trans-Golgi network
Fri Feb 07 00:00:00 UTC 2003
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.
Cell
Yang CH,Axelrod JD,Simon MA
A-11122 was used in immunohistochemistry to study planar polarity signaling in the Drosophila compound eye due to regulation of Frizzled by fat-like cadherins
Fri Mar 08 00:00:00 UTC 2002
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Neuron
Bagri A,Marín O,Plump AS,Mak J,Pleasure SJ,Rubenstein JL,Tessier-Lavigne M
A-11122 was used in immunohistochemistry - free floating to analyze prevention of midline crossing and determination of the dorsoventral position of major axonal pathways in the mammalian forebrain by Slit proteins
Thu Jan 17 00:00:00 UTC 2002
The endoplasmic reticulum cation P-type ATPase Cta4p is required for control of cell shape and microtubule dynamics.
The Journal of cell biology
Façanha AL,Appelgren H,Tabish M,Okorokov L,Ekwall K
A-11122 was used in immunocytochemistry and western blot to characterize the cta4+ gene of fission yeast
Mon Jun 10 00:00:00 UTC 2002
Cytoplasmic linker proteins promote microtubule rescue in vivo.
The Journal of cell biology
Komarova YA,Akhmanova AS,Kojima S,Galjart N,Borisy GG
A-11122 was used in immunocytochemistry to analyze promotion of microtubule rescue in vivo by cytoplasmic linker proteins
Mon Nov 25 00:00:00 UTC 2002
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli.
The Journal of cell biology
Herskovits AA,Shimoni E,Minsky A,Bibi E
A-11122 was used in western blot to study the accumulation of novel membrane-bound ribosome-signal recognition particle receptor complexes and endoplasmic membranes in Escherichia coli
Mon Nov 11 00:00:00 UTC 2002
Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells.
The Journal of cell biology
Kallio MJ,Beardmore VA,Weinstein J,Gorbsky GJ
A-11122 was used in immunoprecipitation and western blot to map the domains of Cdc20 required for its association with kinetochores and centrosomes
Mon Sep 02 00:00:00 UTC 2002
The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive.
The Journal of cell biology
Calapez A,Pereira HM,Calado A,Braga J,Rino J,Carvalho C,Tavanez JP,Wahle E,Rosa AC,Carmo-Fonseca M
A-11122 was used in immunoprecipitation to analyze intranuclear mobility of messenger RNA binding proteins is temperature sensitive and ATP dependent
Mon Dec 09 00:00:00 UTC 2002
Specificity of glomerular targeting by olfactory sensory axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Treloar HB,Feinstein P,Mombaerts P,Greer CA
A-11122 was used in immunohistochemistry - free floating to assess glomerular targeting specificity by olfactory sensory axons
Mon Apr 01 00:00:00 UTC 2002
Meiotic cohesion requires accumulation of ORD on chromosomes before condensation.
Molecular biology of the cell
Balicky EM,Endres MW,Lai C,Bickel SE
A-11122 was used in immunohistochemistry to analyze the requirement of accumulation of ORD on chromosomes before condensation for meiotic cohesion
Fri Nov 01 00:00:00 UTC 2002
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
The Journal of biological chemistry
Tanji C,Yamamoto H,Yorioka N,Kohno N,Kikuchi K,Kikuchi A
A-11122 was used in immunoprecipitation to elucidate the function of the GSK-3beta and AKAP220 complex
Fri Oct 04 00:00:00 UTC 2002
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila.
Cell
Scott K,Brady R,Cravchik A,Morozov P,Rzhetsky A,Zuker C,Axel R
A-11122 was used in immunohistochemistry to identify and characterize a novel family of gustatory receptors in Drosophila
Fri Mar 09 00:00:00 UTC 2001
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
Cell
Zhou XZ,Lu KP
A-11122 was used in western blot to characterize a potent telomerase inhibitor called PinX1, which is a Pin2/TRF1-interacting protein
Fri Nov 02 00:00:00 UTC 2001
Trophic conversion of an obligate photoautotrophic organism through metabolic engineering.
Science (New York, N.Y.)
Zaslavskaia LA,Lippmeier JC,Shih C,Ehrhardt D,Grossman AR,Apt KE
A-11122 was used in immunocytochemistry and western blot to demonstrate that Phaeodactylum tricornutum can thrive on exogenous glucose in the absence of light when just a glucose transporter is introduced
Fri Jun 15 00:00:00 UTC 2001
senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye.
Neuron
Frankfort BJ,Nolo R,Zhang Z,Bellen H,Mardon G
A-11122 was used in immunohistochemistry to analyze the requirement of R8 photoreceptor differentiation in the developing Drosophila eye by senseless repression of rough
Thu Nov 08 00:00:00 UTC 2001
Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes.
The EMBO journal
Wickham ME,Rug M,Ralph SA,Klonis N,McFadden GI,Tilley L,Cowman AF
A-11122 was used in immunocytochemistry and western blot to characterize Plasmodium falciparum-infected human erythrocytes and assembly and trafficking of the cytoadherence complex
Mon Oct 15 00:00:00 UTC 2001
Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research
Davidoff AM,Ng CY,Brown P,Leary MA,Spurbeck WW,Zhou J,Horwitz E,Vanin EF,Nienhuis AW
A-11122 was used in immunohistochemistry - frozen section to study the contribution to tumor neovasculature and restriction in tumor growth in mice when modified to express an angiogenesis inhibitor by bone marrow-derived cells
Sat Sep 01 00:00:00 UTC 2001
A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.
The Journal of cell biology
Lechler T,Jonsdottir GA,Klee SK,Pellman D,Li R
A-11122 was used in immunocytochemistry to elucidate the control by Cdc42 for activation and localization of an Arp2/3-activating motor complex in yeast by a two-tiered mechanism
Mon Oct 15 00:00:00 UTC 2001
A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.
The Journal of cell biology
Hoepfner D,van den Berg M,Philippsen P,Tabak HF,Hettema EH
A-11122 was used in immunocytochemistry to study actin, Myo2p, and Vps1p in peroxisome inheritance and abundance in Saccharomyces cerevisiae
Mon Dec 10 00:00:00 UTC 2001
Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.
Developmental biology
Albrecht KH,Eicher EM
A-11122 was used in immunohistochemistry to test if Sry directs supporting cell precursors to develop into Sertoli cells
Sat Dec 01 00:00:00 UTC 2001
Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor.
The Journal of biological chemistry
Caloca MJ,Wang H,Delemos A,Wang S,Kazanietz MG
A-11122 was used in western blot to demonstrate that beta2-chimaerin is translocated by phorbol esters from the cytosolic to particulate fraction
Fri May 25 00:00:00 UTC 2001
Functional analysis of type 1alpha cGMP-dependent protein kinase using green fluorescent fusion proteins.
The Journal of biological chemistry
Browning DD,Mc Shane M,Marty C,Ye RD
A-11122 was used in immunoprecipitation and western blot to assess the enzymatic properties and intracellular location of cGMP-dependent protein kinases
Fri Apr 20 00:00:00 UTC 2001
Requirement for N-ethylmaleimide-sensitive factor activity at different stages of bacterial invasion and phagocytosis.
The Journal of biological chemistry
Coppolino MG,Kong C,Mohtashami M,Schreiber AD,Brumell JH,Finlay BB,Grinstein S,Trimble WS
A-11122 was used in immunocytochemistry to report that membrane protrusions elicited by Salmonella invasion are N-ethylmaleimide-sensitive factor-independent, whereas maturation of Salmonella-containing vacuoles is N-ethylmaleimide-sensitive factor-depen
Fri Feb 16 00:00:00 UTC 2001
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon.
The Journal of biological chemistry
Kishida M,Michiue T,Yamamoto H,Kishida S,Fukui A,Asashima M,Kikuchi A
A-11122 was used in immunoprecipitation to investigate how Dvl and CKIepsilon synergistically activate the Wnt signaling pathway
Fri Aug 31 00:00:00 UTC 2001
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
Nature
Polleux F,Morrow T,Ghosh A
A-11122 was used in immunohistochemistry to report a chemoattractive effect of Sema3A on apical dendrite
Thu Apr 06 00:00:00 UTC 2000
G proteins mediate changes in cell shape by stabilizing the axis of polarity.
Molecular cell
Nern A,Arkowitz RA
A-11122 was used in western blot to show that stabilization of the growth axis requires positional signaling from either the pheromone receptor or specific bud site selection proteins
Mon May 01 00:00:00 UTC 2000
Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.
The Journal of cell biology
Toyofuku T,Hong Z,Kuzuya T,Tada M,Hori M
A-11122 was used in immunocytochemistry to study the role of Wnt family proteins in in cardiac myocytes
Mon Jul 10 00:00:00 UTC 2000
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.
The Journal of cell biology
Mancini M,Machamer CE,Roy S,Nicholson DW,Thornberry NA,Casciola-Rosen LA,Rosen A
A-11122 was used in immunocytochemistry and immunoprecipitation to study the function of caspase-2 in the Golgi complex
Mon May 01 00:00:00 UTC 2000
Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation.
The Journal of cell biology
Bajno L,Peng XR,Schreiber AD,Moore HP,Trimble WS,Grinstein S
A-11122 was used in immunocytochemistry to investigate VAMP3-containing vesicles
Mon May 01 00:00:00 UTC 2000
The triad targeting signal of the skeletal muscle calcium channel is localized in the COOH terminus of the alpha(1S) subunit.
The Journal of cell biology
Flucher BE,Kasielke N,Grabner M
A-11122 was used in immunocytochemistry to identify regions of alpha(1S) involved in the targeting of the calcium channel into the triads
Mon Oct 16 00:00:00 UTC 2000
The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.
The Journal of biological chemistry
Rauen M,Burtelow MA,Dufault VM,Karnitz LM
A-11122 was used in western blot to report that hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9
Fri Sep 22 00:00:00 UTC 2000
E-cadherin-mediated cell-cell attachment activates Cdc42.
The Journal of biological chemistry
Kim SH,Li Z,Sacks DB
A-11122 was used in immunoprecipitation to study the role of Cdc42 in E-cadherin-mediated cell-cell adhesion
Fri Nov 24 00:00:00 UTC 2000
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
The Journal of biological chemistry
Kadoya T,Kishida S,Fukui A,Hinoi T,Michiue T,Asashima M,Kikuchi A
A-11122 was used in immunocytochemistry, immunoprecipitation, and western blot to identify Axam and elucidate how it regulates the Wnt signaling pathway
Fri Nov 24 00:00:00 UTC 2000
Importance of protein kinase C targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrate.
The Journal of biological chemistry
Ohmori S,Sakai N,Shirai Y,Yamamoto H,Miyamoto E,Shimizu N,Saito N
A-11122 was used in western blot to observe the translocation of myristoylated alanine-rich protein kinase C substrate
Fri Aug 25 00:00:00 UTC 2000
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.
Molecular biology of the cell
Liu CH,Thangada S,Lee MJ,Van Brocklyn JR,Spiegel S,Hla T
A-11122 was used in western blot to elucidate the dynamics and subcellular localization of sphingosine-1-phosphate-EDG-1 interactions
Thu Apr 01 00:00:00 UTC 1999
Dual-function reporter protein for analysis of gene expression in living cells.
BioTechniques
Day RN,Kawecki M,Berry D
A-11122 was used in immunoprecipitation and western blot to create and characterize an expression vector encoding a chimeric protein in which green fluorescent protein was tethered to firefly luciferase
Sun Nov 01 00:00:00 UTC 1998
Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis.
The Journal of biological chemistry
Nass R,Rao R
A-11122 was used in western blot to study the role of intracellular Na+/H+ exchangers using yeast
Fri Aug 14 00:00:00 UTC 1998
