Product References
Genetic Identification of Neural Circuits Essential for Active Avoidance Fear Conditioning in Adult Zebrafish.
Methods in molecular biology (Clifton, N.J.)
Lal P,Tanabe H,Kawakami K
A-6455 was used in Immunohistochemistry to describe a method to inhibit a specific neuronal population in adult zebrafish brain and assess their role in a learning behavior.
Wed Sep 06 00:00:00 UTC 2023
PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability.
Oncogenesis
Martínez N,Gragera T,de Lucas MP,Cámara AB,Ballester A,Anta B,Fernández-Medarde A,López-Briones T,Ortega J,Peña-Jiménez D,Barbáchano A,Montero-Calle A,Cordero V,Barderas R,Iglesias T,Yunta M,Oliva JL,Muñoz A,Santos E,Zarich N,Rojas-Cabañeros JM
A-6455 was used in Immunoprecipitation to demonstrate that both PKD and the COP9/Signalosome play a significant role in control of Spry2 intracellular stability and support the consideration of the PKD/COP9 complex as a potential therapeutic target in tumors where Spry2 expression is reduced.
Wed Apr 12 00:00:00 UTC 2023
Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit.
Cell reports
Bilash OM,Chavlis S,Johnson CD,Poirazi P,Basu J
A-6455 was used in Immunohistochemistry-immunofluorescence to highlight a cortically driven GABAergic microcircuit mechanism that gates nonlinear dendritic computations, which may support compartment-specific coding of multisensory contextual features within the hippocampus.
Tue Jan 31 00:00:00 UTC 2023
Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladenine-type cytokinins.
Plant communications
Zhao J,Deng X,Qian J,Liu T,Ju M,Li J,Yang Q,Zhu X,Li W,Liu CJ,Jin Z,Zhang K
A-6455 was used in Western Blot to investigate the biochemical properties of Arabidopsis ATP-binding cassette transporter subfamily G14 and its transporter activity toward isopentenyladenine-type Cytokinins.
Mon Mar 13 00:00:00 UTC 2023
Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus.
Nature neuroscience
Tossell K,Yu X,Giannos P,Anuncibay Soto B,Nollet M,Yustos R,Miracca G,Vicente M,Miao A,Hsieh B,Ma Y,Vyssotski AL,Constandinou T,Franks NP,Wisden W
A-6455 was used in Immunohistochemistry to suggest that the PFC instructs the hypothalamus to ensure that optimal sleep takes place in a suitable place.
Sun Oct 01 00:00:00 UTC 2023
Monitoring cell fate in 3D organotypic human squamous epithelial cultures.
STAR protocols
Hatterschide J,Natale CA,Ridky TW,White EA
A-6455 was used in Immunohistochemistry-immunofluorescence to model the effects of changes to a small number of cells, such as those arising from a mutation or a virus infection, in stratified epithelia.
Fri Mar 17 00:00:00 UTC 2023
Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels.
Channels (Austin, Tex.)
Heigl T,Netzer MA,Zanetti L,Ganglberger M,Fernández-Quintero ML,Koschak A
A-6455 was used in Western Blotting to identify alterations in their biophysical properties, such as a hyperpolarizing shift of the activation threshold and an increase in slope factor of activation and inactivation.
Fri Dec 01 00:00:00 UTC 2023
Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.
Nature communications
Vergara Z,Gomez MS,Desvoyes B,Sequeira-Mendes J,Masoud K,Costas C,Noir S,Caro E,Mora-Gil V,Genschik P,Gutierrez C
A-6455 was used in Immunocytochemistry-immunofluorescence to show that the Arabidopsis genome encodes for two ORC1 proteins highly similar in amino acid sequence and that have partially overlapping expression domains but with distinct functions.
Tue Mar 07 00:00:00 UTC 2023
Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation.
iScience
Mishra S,Ma J,McKoy D,Sasaki M,Farinelli F,Page RC,Ranek MJ,Zachara N,Kass DA
A-6455 was used in Western Blot to show TRPC6 is constitutively O-GlcNAcylated at Ser14, Thr70, and Thr221 in the N-terminus ankryn-4 (AR4) and linker (LH1) domains.
Fri Mar 17 00:00:00 UTC 2023
Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology.
Biology open
DeSantis DF,Neal SJ,Zhou Q,Pignoni F
A-6455 was used in Immunohistochemistry to propose that AJ-Jub-Yki signaling in PE cells regulates PE cell contractile properties and/or attachment to the extracellular matrix to promote normal eye disc morphology.
Wed Mar 15 00:00:00 UTC 2023
Active antennal movements in Drosophila can tune wind encoding.
Current biology : CB
Suver MP,Medina AM,Nagel KI
A-6455 was used in Cell Culture to measure how tethered Drosophila move their antennae in the presence of sensory stimuli and identify genetic reagents for controlling antennal movement.
Mon Feb 27 00:00:00 UTC 2023
Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions.
PLoS genetics
Melamed D,Choi A,Reilein A,Tavaré S,Kalderon D
A-6455 was used in Immunohistochemistry to find a prominent G2/M cycling restriction of posterior FSCs together with an A/P graded G1/S restriction, that JAK-STAT signaling promotes both G1/S and G2/M transitions, and that PI3 kinase signaling principally stimulates the G2/M transition.
Fri Sep 01 00:00:00 UTC 2023
Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG.
Nature communications
Ali A,Vineethakumari C,Lacasa C,Lüders J
A-6455 was used in Immunocytochemistry to show that at interphase centrosomes, rather than adapters, the microtubule polymerase ch-TOG (also named chTOG or CKAP5) ultimately controls γTuRC recruitment and activation.
Thu Jan 26 00:00:00 UTC 2023
BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging.
Science advances
Blesa J,Pineda-Pardo JA,Inoue KI,Gasca-Salas C,Balzano T,Del Rey NL,Reinares-Sebastián A,Esteban-García N,Rodríguez-Rojas R,Márquez R,Ciorraga M,Del Álamo M,García-Cañamaque L,Ruiz de Aguiar S,Rachmilevitch I,Trigo-Damas I,Takada M,Obeso JA
A-6455 was used in Immunohistochemistry to report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson's disease using low-intensity focus ultrasound in adult macaque monkeys.
Fri Apr 21 00:00:00 UTC 2023
Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores.
Nature communications
Smurova K,Damizia M,Irene C,Stancari S,Berto G,Perticari G,Iacovella MG,D'Ambrosio I,Giubettini M,Philippe R,Baggio C,Callegaro E,Casagranda A,Corsini A,Polese VG,Ricci A,Dassi E,De Wulf P
A-6455 was used in Immunocytochemistry to suggest that CEN regulation by Rio1/RioK1 is evolutionary conserved.
Thu Jun 01 00:00:00 UTC 2023
Structure-Function of the Human WAC Protein in GABAergic Neurons: Towards an Understanding of Autosomal Dominant DeSanto-Shinawi Syndrome.
Biology
Rudolph HC,Stafford AM,Hwang HE,Kim CH,Prokop JW,Vogt D
A-6455 was used in Western Blotting to provide new insights into the potential roles of this critical developmental gene, establishing a platform to assess further translational studies, including the screening of missense genetic variants in WAC.
Wed Apr 12 00:00:00 UTC 2023
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.
Brain : a journal of neurology
Marcotti A,Fernández-Trillo J,González A,Vizcaíno-Escoto M,Ros-Arlanzón P,Romero L,Vela JM,Gomis A,Viana F,de la Peña E
A-6455 was used in Immunoprecipitation to uncover the mechanisms behind Sigma-1 receptor antagonist effectiveness in preventing and treating chemotherapy-induced peripheral neuropathy and neuropathic pain.
Mon Feb 13 00:00:00 UTC 2023
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2-Induced Inflammation.
Molecular pharmacology
Yang F,Liu C,Li P,Wu A,Ma-Lauer Y,Zhang H,Su Z,Lu W,von Brunn A,Zhu D
A-6455 was used in Immunoprecipitation to provide new evidence for targeting CyPA in the treatment of coronavirus disease 2019 (COVID-19) as well as the potential of developing CyPA inhibitors for broad-spectrum inhibition of CoVs.
Fri Dec 01 00:00:00 UTC 2023
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila.
iScience
Calvin-Cejudo L,Martin F,Mendez LR,Coya R,Castañeda-Sampedro A,Gomez-Diaz C,Alcorta E
A-6455 was used in Immunohistochemistry-immunofluorescence to report a functional role for the glia that surround the soma of the olfactory receptor neurons (OSNs) in adult Drosophila.
Fri Jan 20 00:00:00 UTC 2023
Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.
BMC biology
Dong Z,Pang L,Liu Z,Sheng Y,Li X,Thibault X,Reilein A,Kalderon D,Huang J
A-6455 was used in Immunohistochemistry-immunofluorescence to establish an important resource of scRNA-seq profiles for FSCs and their immediate derivatives that is based on precise spatial location and functionally established stem cell identity, and facilitates future genetic investigation of regulatory interactions guiding FSC behavior.
Tue Jun 20 00:00:00 UTC 2023
Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.
Neuron
Albisetti GW,Ganley RP,Pietrafesa F,Werynska K,Magalhaes de Sousa M,Sipione R,Scheurer L,Bösl MR,Pelczar P,Wildner H,Zeilhofer HU
A-6455 was used in Immunohistochemistry-immunofluorescence to identify a hitherto unknown spinal circuit that tunes cold sensitivity.
Wed Jan 04 00:00:00 UTC 2023
An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.
PLoS biology
Wong W,Estep JA,Treptow AM,Rajabli N,Jahncke JN,Ubina T,Wright KM,Riccomagno MM
A-6455 was used in Immunohistochemistry to establish a new and essential role for Cas adaptor proteins during the formation of cortical circuits and reveal a signaling axis controlling cortical scaffold formation.
Tue Aug 01 00:00:00 UTC 2023
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.
Nature
Moiseeva V,Cisneros A,Sica V,Deryagin O,Lai Y,Jung S,Andrés E,An J,Segalés J,Ortet L,Lukesova V,Volpe G,Benguria A,Dopazo A,Benitah SA,Urano Y,Del Sol A,Esteban MA,Ohkawa Y,Serrano AL,Perdiguero E,Muñoz-Cánoves P
A-6455 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to provide a technique for isolating in vivo senescent cells, define a senescence blueprint for muscle, and uncover unproductive functional interactions between senescent cells and stem cells in regenerative niches that can be overcome.
Sun Jan 01 00:00:00 UTC 2023
Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.
Science advances
Tsukita K,Kitamata M,Kashihara H,Yano T,Fujiwara I,Day TF,Katsuno T,Kim J,Takenaga F,Tanaka H,Park S,Miyata M,Watanabe H,Kondoh G,Takahashi R,Tamura A,Tsukita S
A-6455 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot, Immunomicroscopy to establish that LLPS of the actin nucleator Cobl mediated dynamic microtubule-actin cross-talk in junctions, which fine-tuned the epithelial barrier.
Wed Feb 15 00:00:00 UTC 2023
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Communications biology
Chiu TY,Lo CH,Lin YH,Lai YD,Lin SS,Fang YT,Huang WS,Huang SY,Tsai PY,Yang FH,Chong WM,Wu YC,Tsai HC,Liu YW,Hsu CL,Liao JC,Wang WJ
A-6455 was used in Immunocytochemistry and Western Blotting to suggest that INPP5E is a new player in phosphoinositide manipulation at the synapse, controlling the TCR signaling cascade.
Tue Sep 05 00:00:00 UTC 2023
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Communications biology
Chiu TY,Lo CH,Lin YH,Lai YD,Lin SS,Fang YT,Huang WS,Huang SY,Tsai PY,Yang FH,Chong WM,Wu YC,Tsai HC,Liu YW,Hsu CL,Liao JC,Wang WJ
A-6455 was used in Immunocytochemistry and Western Blotting to suggest that INPP5E is a new player in phosphoinositide manipulation at the synapse, controlling the TCR signaling cascade.
Tue Sep 05 00:00:00 UTC 2023
A phosphate-sensing organelle regulates phosphate and tissue homeostasis.
Nature
Xu C,Xu J,Tang HW,Ericsson M,Weng JH,DiRusso J,Hu Y,Ma W,Asara JM,Perrimon N
A-6455 was used in Immunohistochemistry to identify connector of kinase to AP-1 (Cka), a component of the STRIPAK complex and JNK signalling3, as the mediator of PXo knockdown- or Pi starvation-induced hyperproliferation.
Mon May 01 00:00:00 UTC 2023
The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption.
Nature communications
Ding W,Yang L,Shi E,Kim B,Low S,Hu K,Gao L,Chen P,Ding W,Borsook D,Luo A,Choi JH,Wang C,Akeju O,Yang J,Ran C,Schreiber KL,Mao J,Chen Q,Feng G,Shen S
A-6455 was used in Immunohistochemistry to suggest that TRN NADA signaling is critical for CSD-induced hyperalgesia.
Wed Oct 25 00:00:00 UTC 2023
Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate.
The Journal of biological chemistry
Kriachkov V,Ormsby AR,Kusnadi EP,McWilliam HEG,Mintern JD,Amarasinghe SL,Ritchie ME,Furic L,Hatters DM
A-6455 was used in Western Blotting to find that genes regulating stalling on polyadenosine mRNA coding for poly-Lys, a canonical RQC substrate, act differently in the case of arginine-rich DPRs.
Sun Jan 01 00:00:00 UTC 2023
Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway.
Nature immunology
Tanaka T,Okuda H,Isonishi A,Terada Y,Kitabatake M,Shinjo T,Nishimura K,Takemura S,Furue H,Ito T,Tatsumi K,Wanaka A
A-6455 was used in Immunohistochemistry-immunofluorescence to identify Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain sensitivity.
Wed Mar 01 00:00:00 UTC 2023
Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex.
Nature communications
Alonso I,Scheer I,Palacio-Manzano M,Frézel-Jacob N,Philippides A,Prsa M
A-6455 was used in Immunohistochemistry to reveal that proprioception is represented in both sensory and motor cortical areas.
Wed Apr 12 00:00:00 UTC 2023
A detailed redescription of the mesoderm/neural crest cell boundary in the murine orbitotemporal region integrates the mammalian cranium into a pan-amniote cranial configuration.
Evolution & development
Kuroda S,Adachi N,Kuratani S
A-6455 was used in Immunohistochemistry (Paraffin) to investigate the embryonic origin of skeletal elements in the murine orbitotemporal region by combining genetic cell lineage analysis with detailed morphological observation.
Sun Jan 01 00:00:00 UTC 2023
Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice.
The Journal of clinical investigation
Ding W,Fischer L,Chen Q,Li Z,Yang L,You Z,Hu K,Wu X,Zhou X,Chao W,Hu P,Dagnew TM,Dubreuil DM,Wang S,Xia S,Bao C,Zhu S,Chen L,Wang C,Wainger B,Jin P,Mao J,Feng G,Harnett MT,Shen S
A-6455 was used in Immunohistochemistry-immunofluorescence to report that orofacial spontaneous pain activated a specific area within the primary somatosensory cortex (S1), displaying synchronized neural dynamics revealed by intravital two-photon calcium imaging.
Wed Mar 01 00:00:00 UTC 2023
Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance.
Microbiology spectrum
Wessel AK,Yoshii Y,Reder A,Boudjemaa R,Szczesna M,Betton JM,Bernal-Bayard J,Beloin C,Lopez D,Völker U,Ghigo JM
A-6455 was used in Immunocytochemistry to provide new insights into the cellular processes associated with SPFH proteins in E. coli.
Thu Aug 17 00:00:00 UTC 2023
Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Genes to cells : devoted to molecular & cellular mechanisms
Nemoto K,Masuko K,Fuse N,Kurata S
A-6455 was used in Immunohistochemistry to propose a model in which Dilp8-Drl signaling organizes cell fate conversion in the imaginal disc during TD.
Fri Dec 01 00:00:00 UTC 2023
NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity.
Neuron
Chipman PH,Fetter RD,Panzera LC,Bergerson SJ,Karmelic D,Yokoyama S,Hoppa MB,Davis GW
A-6455 was used in Immunohistochemistry to show that this compensatory plasticity can be induced within minutes, requires postsynaptic NMDARs, and is expressed via correlated increases in dendritic spine volume, active zone area, and docked vesicle number.
Wed Oct 19 00:00:00 UTC 2022
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.
Autophagy
Burbidge K,Rademacher DJ,Mattick J,Zack S,Grillini A,Bousset L,Kwon O,Kubicki K,Simon A,Melki R,Campbell EM
A-6455 was used in Western Blot to demonstrate that LGALS3 (galectin 3) mediates the release of SNCA following vesicular damage. SNCA release is also dependent on TRIM16 (tripartite motif containing 16) and ATG16L1 (autophagy related 16 like 1), providing evidence that secretion of SNCA is mediated by an autophagic secretory pathway.
Sun May 01 00:00:00 UTC 2022
Striatal dopamine signals are region specific and temporally stable across action-sequence habit formation.
Current biology : CB
van Elzelingen W,Warnaar P,Matos J,Bastet W,Jonkman R,Smulders D,Goedhoop J,Denys D,Arbab T,Willuhn I
A-6455 was used in Immunohistochemistry to demonstrate that dopamine signals do not shift regionally during habit formation and that dopamine in DMS, but not VMS or DLS, determines habit bias, attributing "habit functions" to a region previously associated exclusively with non-habitual behavior.
Mon Mar 14 00:00:00 UTC 2022
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells.
Cellular and molecular life sciences : CMLS
Cacho-Navas C,Reglero-Real N,Colás-Algora N,Barroso S,de Rivas G,Stamatakis K,Feito J,Andrés G,Fresno M,Kremer L,Correas I,Alonso MA,Millán J
A-6455 was used in Immunohistochemistry to explore molecular mechanisms that determine ICAM-1 localization into apical membrane domains of polarized hepatic epithelial cells.
Sun Jan 09 00:00:00 UTC 2022
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy.
The Journal of cell biology
Ohshima T,Yamamoto H,Sakamaki Y,Saito C,Mizushima N
A-6455 was used in Immuno-assay to suggest that NCOA4 acts not only as a canonical autophagy receptor but also as a driver to form ferritin condensates to facilitate the degradation of these condensates by macroautophagy (i.e., macroferritinophagy) and endosomal microautophagy (i.e., microferritinophagy).
Mon Oct 03 00:00:00 UTC 2022
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.
Development (Cambridge, England)
Katreddi RR,Taroc EZM,Hicks SM,Lin JM,Liu S,Xiang M,Forni PE
A-6455 was used in Immunocytochemistry-immunoflourescence to indicate that Notch signaling plays a pivotal role in triggering the binary differentiation dichotomy in the VNO of rodents.
Fri Jul 01 00:00:00 UTC 2022
Nucleolin loss of function leads to aberrant Fibroblast Growth Factor signaling and craniofacial anomalies.
Development (Cambridge, England)
Dash S,Trainor PA
A-6455 was used in Immunohistochemistry to examine the function of the most abundant nucleolar phosphoprotein, Nucleolin (Ncl), in vertebrate development. ncl mutant (ncl-/-) zebrafish present with craniofacial anomalies such as mandibulofacial hypoplasia.
Wed Jun 15 00:00:00 UTC 2022
Time Course of Activity-Dependent Changes in Auditory Nerve Synapses Reveals Multiple Underlying Cellular Mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wong NF,Xu-Friedman MA
A-6455 was used in Immunohistochemistry to study the time course of activity-dependent changes that occur at auditory nerve synapses in mice of both sexes after noise exposure and conductive hearing loss.
Wed Mar 23 00:00:00 UTC 2022
Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pop IV,Espinosa F,Blevins CJ,Okafor PC,Ogujiofor OW,Goyal M,Mona B,Landy MA,Dean KM,Gurumurthy CB,Lai HC
A-6455 was used in Immunocytochemistry to define the unique anatomic trajectories of long-range direct and indirect spinocerebellar pathways as well as local intersegmental spinal circuits using genetic tools in both male and female mice.
Wed Jan 26 00:00:00 UTC 2022
Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex.
Molecular neurobiology
Crespo I,Pignatelli J,Kinare V,Méndez-Gómez HR,Esgleas M,Román MJ,Canals JM,Tole S,Vicario C
A-6455 was used in Immunohistochemistry to indicate that Tbr1 misexpression in cortical NPCs delays or disrupts neuronal migration, neuronal specification, dendrite development and the formation of the callosal tract.
Thu Sep 01 00:00:00 UTC 2022
Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation.
Cell reports
Mushtaq Z,Aavula K,Lasser DA,Kieweg ID,Lion LM,Kins S,Pielage J
A-6455 was used in Immunohistochemistry to provide insights into the molecular mechanisms underlying neurodegeneration-induced PHP with potential neurotherapeutic applications.
Tue Nov 29 00:00:00 UTC 2022
Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on the in vivo Biological Context.
Frontiers in cell and developmental biology
Sarrio D,Rojo-Sebastián A,Teijo A,Pérez-López M,Díaz-Martín E,Martínez L,Morales S,García-Sanz P,Palacios J,Moreno-Bueno G
A-6455 was used in Western Blotting to study whether GSDMB has inherent oncogenic, or tumor suppressor function in vivo in preclinical mouse models.
Wed Mar 16 00:00:00 UTC 2022
Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization.
Science advances
Norris MJ,Husby ML,Kiosses WB,Yin J,Saxena R,Rennick LJ,Heiner A,Harkins SS,Pokhrel R,Schendel SL,Hastie KM,Landeras-Bueno S,Salie ZL,Lee B,Chapagain PP,Maisner A,Duprex WP,Stahelin RV,Saphire EO
A-6455 was used in Immunocytochemistry to demonstrate that PI(4,5)P2 binding induces conformational and electrostatic changes in the M protein surface that trigger membrane deformation, matrix layer polymerization, and virion assembly.
Fri Jul 22 00:00:00 UTC 2022
Expression of PEI-coated gold nanoparticles carrying exogenous gene in periwinkle mesophyll cells and its practice in huanglongbing research.
iScience
Zhang J,Lei W,Meng Y,Zhou C,Zhang B,Yuan J,Wang M,Xu D,Meng X,Chen W
A-6455 was used in Immunocytochemistry-immunoflourescence to confirm that the expression of exogenous NPR1-GFP could reduce the CLas titers by promoting the expression of PR (pathogenesis related) genes and ICS (isochorismate synthase) gene.
Fri Jun 17 00:00:00 UTC 2022
Tbx15/18/22 shares a binding site with Tbx6-r.b to maintain expression of a muscle structural gene in ascidian late embryos.
Developmental biology
Yu D,Iwamura Y,Satou Y,Oda-Ishii I
A-6455 was used in Immunohistochemistry-immunofluorescence to reveal the mechanisms of maintenance of transcription of muscle structural genes in late embryos in which Tbx15/18/22 takes the place of Tbx6-r.b.
Tue Mar 01 00:00:00 UTC 2022
An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos.
The Journal of experimental biology
Jevtić P,Elliott KW,Watkins SE,Sreter JA,Jovic K,Lehner IB,Baures PW,Tsavalas JG,Levy DL,Varga K
A-6455 was used in Western Blotting to show the potential of an insect antifreeze protein to confer cryoprotection in amphibian eggs and embryos.
Tue Feb 15 00:00:00 UTC 2022
chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.
Developmental cell
Tseng CY,Burel M,Cammer M,Harsh S,Flaherty MS,Baumgartner S,Bach EA
A-6455 was used in Immunohistochemistry-immunofluorescence to suggest that the influence of GSC competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.
Mon Jan 10 00:00:00 UTC 2022
Carbon starvation, senescence and specific mitochondrial stresses, but not nitrogen starvation and general stresses, are major triggers for mitophagy in Arabidopsis.
Autophagy
Kacprzak SM,Van Aken O
A-6455 was used in Western Blotting to develop novel reporter lines to monitor mitophagy in plants and surveyed the rate of mitophagy under a wide range of stresses and developmental conditions.
Thu Dec 01 00:00:00 UTC 2022
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.
Neuron
Martins LF,Brambilla I,Motta A,de Pretis S,Bhat GP,Badaloni A,Malpighi C,Amin ND,Imai F,Almeida RD,Yoshida Y,Pfaff SL,Bonanomi D
A-6455 was used in Immunohistochemistry-immunofluorescence to show that Plexin-D1 receptor is required in endothelial cells for development of neuromuscular connectivity.
Wed Dec 21 00:00:00 UTC 2022
Phospholipase Dε interacts with autophagy-related protein 8 and promotes autophagy in Arabidopsis response to nitrogen deficiency.
The Plant journal : for cell and molecular biology
Yao S,Peng S,Wang X
A-6455 was used in Western Blotting to suggest that PLDε promotes autophagy in plant response to nitrogen deficiency.
Tue Mar 01 00:00:00 UTC 2022
Structures and gating mechanisms of human bestrophin anion channels.
Nature communications
Owji AP,Wang J,Kittredge A,Clark Z,Zhang Y,Hendrickson WA,Yang T
A-6455 was used in Western Blotting to report cryo-EM structures of wild-type human Best1 and Best2 in various states at up to 1.8 Å resolution.
Mon Jul 04 00:00:00 UTC 2022
Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic.
The Journal of biological chemistry
Hagenston AM,Yan J,Bas-Orth C,Tan Y,Sekler I,Bading H
A-6455 was used in Western Blotting to investigate NCLX expression effects on mitochondria in neurones.
Tue Feb 01 00:00:00 UTC 2022
Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wong NF,Xu-Friedman MA
A-6455 was used in Immunohistochemistry to reveal that auditory nerve synapses are unexpectedly sensitive to activity and can show dramatic, long-lasting changes in a few hours that could affect hearing.
Wed Aug 10 00:00:00 UTC 2022
Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.
eLife
Sato H,Hatakeyama J,Iwasato T,Araki K,Yamamoto N,Shimamura K
A-6455 was used in Immunohistochemistry to provide an actual case in which highly site-specific axon projection confers further regional complexity upon the target field through locally secreting signaling molecules from axon terminals.
Tue Mar 15 00:00:00 UTC 2022
Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature
Owji AP,Yu K,Kittredge A,Wang J,Zhang Y,Yang T
A-6455 was used in Western Blotting to uncover a directional permeability of BEST2 to glutamate that heavily favours glutamate exit, identify glutamine synthetase (GS) as a binding partner of BEST2 in the ciliary body of the eye, and solve the structure of the BEST2-GS complex.
Tue Nov 01 00:00:00 UTC 2022
Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs.
BMC biology
Soppina P,Patel N,Shewale DJ,Rai A,Sivaramakrishnan S,Naik PK,Soppina V
A-6455 was used in Western Blotting to show that the K-loop, a positively charged insert in the loop12 of the kinesin-3 motor domain promotes microtubule bending, an interesting phenomenon often observed in cells, which requires further investigation to understand its cellular and physiological significance.
Wed Aug 10 00:00:00 UTC 2022
The actin-cytoskeleton associating protein BASP1 regulates neural progenitor localization in the neural tube.
Genesis (New York, N.Y. : 2000)
Mac Donald K,Iulianella A
A-6455 was used in Immunohistochemistry to suggest a role for BASP1 in regulating the apical polarity of progenitor cells and axon trajectories from developing neurons.
Tue Feb 01 00:00:00 UTC 2022
CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
Molecular psychiatry
Sitbon J,Nestvogel D,Kappeler C,Nicolas A,Maciuba S,Henrion A,Troudet R,Courtois E,Grannec G,Latapie V,Barau C,Le Corvoisier P,Pietrancosta N,Henry C,Leboyer M,Etain B,Nosten-Bertrand M,Martin TFJ,Rhee J,Jamain S
A-6455 was used in Western Blotting to suggest that dysfunction in calcium-dependent vesicular exocytosis may increase the sensitivity to environmental stressors enhancing the risk of developing bipolar disorder.
Tue Feb 01 00:00:00 UTC 2022
Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo.
Methods in molecular biology (Clifton, N.J.)
Katow H,Vasudevan D,Ryoo HD
A-6455 was used in Western Blot to detect UPR in Drosophila melanogaster.
Tue Mar 29 00:00:00 UTC 2022
The PV2 cluster of parvalbumin neurons in the murine periaqueductal gray: connections and gene expression.
Brain structure & function
Leemann S,Babalian A,Girard F,Davis F,Celio MR
A-6455 was used in Immunohistochemistry-immunofluorescence to investigate the role and regulation of PV2 neurons.
Fri Jul 01 00:00:00 UTC 2022
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.
Nature communications
Miozzo F,Valencia-Alarcón EP,Stickley L,Majcin Dorcikova M,Petrelli F,Tas D,Loncle N,Nikonenko I,Bou Dib P,Nagoshi E
A-6455 was used in Immunohistochemistry to reveal the essential and conserved role of Fer2 homologs in the mitochondrial maintenance of midbrain DA neurons, opening new perspectives for modeling and treating PD.
Thu Mar 17 00:00:00 UTC 2022
Preferred Migration of Mitochondria toward Cells and Tissues with Mitochondrial Damage.
International journal of molecular sciences
Lee SE,Kang YC,Kim Y,Kim S,Yu SH,Park JH,Kim IH,Kim HY,Han K,Lee HK,Kim SH,Kim CH
A-6455 was used in Western Blot to show for the first time that exogenous mitochondria are preferentially trafficked to cells and tissues in which mitochondria are damaged, which has implications for the delivery of therapeutic agents to injured or diseased sites.
Mon Dec 12 00:00:00 UTC 2022
Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies.
eLife
Xu J,Kim AR,Cheloha RW,Fischer FA,Li JSS,Feng Y,Stoneburner E,Binari R,Mohr SE,Zirin J,Ploegh HL,Perrimon N
A-6455 was used in Western Blot to characterize two short (15aa) NanoTag epitopes, 127D01 and VHH05, and their corresponding high-affinity nanobodies.
Tue Jan 25 00:00:00 UTC 2022
A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis.
Science advances
Kumar R,Francis V,Kulasekaran G,Khan M,Armstrong GAB,McPherson PS
A-6455 was used in Western Blot to identify an unexpected diversity in DENN domain-mediated activation of Rabs, a previously unidentified non-Rab substrate for a DENN domain, and a new regulatory protein in primary ciliogenesis.
Fri Feb 25 00:00:00 UTC 2022
Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila.
Cell reports
Aggarwal P,Liu Z,Cheng GQ,Singh SR,Shi C,Chen Y,Sun LV,Hou SX
A-6455 was used in Immunohistochemistry-immunofluorescence to identify an evolutionarily conserved pathway that sustains stem cells and CSCs, and its ablation results in an immunogenic cascade that promotes death of stem cells and CSCs as well as antitumor immunity.
Tue Jun 21 00:00:00 UTC 2022
Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
Molecular therapy. Nucleic acids
Stein CS,McLendon JM,Witmer NH,Boudreau RL
A-6455 was used in Western Blot to find that moderate miR-181a/b overexpression exacerbated aSyn-induced DA neuronal loss, whereas miR-181 inhibition was neuroprotective relative to controls (GFP alone and/or scrambled RNA).
Tue Jun 14 00:00:00 UTC 2022
Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury.
Theranostics
Chen HR,Chen CW,Kuo YM,Chen B,Kuan IS,Huang H,Lee J,Anthony N,Kuan CY,Sun YY
A-6455 was used in Immunohistochemistry to explore the roles of monocytes in microglia ontogeny and the pathogenesis of neonatal cerebral hypoxic-ischemic (HI) brain injury in mice.
Thu Mar 10 00:00:00 UTC 2022
Walking strides direct rapid and flexible recruitment of visual circuits for course control in Drosophila.
Neuron
Fujiwara T,Brotas M,Chiappe ME
A-6455 was used in Immunohistochemistry-immunofluorescence to demonstrate the presence of an elegant stride-based mechanism operating at multiple timescales for context-dependent course control, and propose that this mechanism functions as a general basis for the adaptive control of locomotion.
Wed Jul 06 00:00:00 UTC 2022
Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury.
JCI insight
Lu P,Freria CM,Graham L,Tran AN,Villarta A,Yassin D,Huie JR,Ferguson AR,Tuszynski MH
A-6455 was used in Immunohistochemistry-immunofluorescence to identify a critical and synergistic role of rehabilitation and neural stem cell therapy in driving neural plasticity to support functional recovery after chronic and severe SCI.
Mon Aug 22 00:00:00 UTC 2022
A protein-trap allele reveals roles for Drosophila ATF4 in photoreceptor degeneration, oogenesis and wing development.
Disease models & mechanisms
Vasudevan D,Katow H,Huang HW,Tang G,Ryoo HD
A-6455 was used in Immunohistochemistry-immunofluorescence to report that a protein-trap Minos-mediated integration cassette insertion in the crc locus generates a Crc-GFP fusion protein that allows visualization of Crc activity in vivo.
Tue Mar 01 00:00:00 UTC 2022
Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation.
eLife
Merour E,Hmidan H,Marie C,Helou PH,Lu H,Potel A,Hure JB,Clavairoly A,Shih YP,Goudarzi S,Dussaud S,Ravassard P,Hafizi S,Lo SH,Hassan BA,Parras C
A-6455 was used in Immunohistochemistry to reveal a specific time window during which transcriptional upregulation of Tns3 in immature OLs is required for OL differentiation likely by mediating integrin-β1 survival signaling to the actin cytoskeleton as OL undergo the large morphological changes required for their terminal differentiation.
Mon Oct 10 00:00:00 UTC 2022
Prolactin Action Is Necessary for Parental Behavior in Male Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Smiley KO,Brown RSE,Grattan DR
A-6455 was used in Immunohistochemistry to show that the hormone prolactin has a role in the male brain to promote paternal behavior.
Wed Nov 02 00:00:00 UTC 2022
PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
eLife
Sawai A,Pfennig S,Bulajić M,Miller A,Khodadadi-Jamayran A,Mazzoni EO,Dasen JS
A-6455 was used in Immunohistochemistry to indicate that PRC1 can function in the absence of de novo PRC2-dependent histone methylation to maintain chromatin topology and postmitotic neuronal fate.
Fri Jan 07 00:00:00 UTC 2022
Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167.
International journal of molecular sciences
Ghilarducci K,Cabana VC,Harake A,Cappadocia L,Lussier MP
A-6455 was used in Immunoprecipitation to report that RNF167, a transmembrane endolysosomal ubiquitin ligase, can ubiquitinate Rab7.
Sat Jul 16 00:00:00 UTC 2022
Phylogenetic convergence of phase separation and mitotic function in the disordered protein BuGZ.
Protein science : a publication of the Protein Society
Chin AF,Zheng Y,Hilser VJ
A-6455 was used in Western Blotting to observe that evolution has conserved the ability for six homologs of the mitotic IDP BuGZ to undergo liquid-liquid phase separation (LLPS) and to serve the same mitotic function and that cellular context may tune LLPS.
Fri Apr 01 00:00:00 UTC 2022
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.
Nature neuroscience
Kjaerby C,Andersen M,Hauglund N,Untiet V,Dall C,Sigurdsson B,Ding F,Feng J,Li Y,Weikop P,Hirase H,Nedergaard M
A-6455 was used in Immunohistochemistry to show that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles.
Mon Aug 01 00:00:00 UTC 2022
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses.
Immunity
Banta KL,Xu X,Chitre AS,Au-Yeung A,Takahashi C,O'Gorman WE,Wu TD,Mittman S,Cubas R,Comps-Agrar L,Fulzele A,Bennett EJ,Grogan JL,Hui E,Chiang EY,Mellman I
A-6455 was used in Immunoprecipitation to conclude that full restoration of CD226 signaling, and optimal anti-tumor CD8+ T cell responses, requires blockade of TIGIT and PD-1, providing a mechanistic rationale for combinatorial targeting in the clinic.
Tue Mar 08 00:00:00 UTC 2022
Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
The FEBS journal
Bakopoulos D,Whisstock JC,Warr CG,Johnson TK
A-6455 was used in Immunocytochemistry to support a novel mechanism for the regulation of macrophage self-renewal rates by the dynamic transcriptional control of Pvf2.
Fri Jul 01 00:00:00 UTC 2022
Structural basis of organic cation transporter-3 inhibition.
Nature communications
Khanppnavar B,Maier J,Herborg F,Gradisch R,Lazzarin E,Luethi D,Yang JW,Qi C,Holy M,Jäntsch K,Kudlacek O,Schicker K,Werge T,Gether U,Stockner T,Korkhov VM,Sitte HH
A-6455 was used in Western Blotting to describe the cryo-EM structure of human OCT3.
Mon Nov 07 00:00:00 UTC 2022
Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis.
Journal of experimental & clinical cancer research : CR
Zhang J,Li Y,Liu H,Zhang J,Wang J,Xia J,Zhang Y,Yu X,Ma J,Huang M,Wang J,Wang L,Li Q,Cui R,Yang W,Xu Y,Feng W
A-6455 was used in Western Blot to suggest that PCMT1 has the potential to be a therapeutic target in metastatic ovarian cancer.
Sat Jan 15 00:00:00 UTC 2022
Functional Characterization of Non-Ankyrin Repeat Domains of Orientia tsutsugamushi Ank Effectors Reveals Their Importance for Molecular Pathogenesis.
Infection and immunity
Gupta S,Hunt JR,Adcox HE,Andersen SE,Gumpf JJ,Green RS,Beyer AR,Evans SM,VieBrock L,Read CB,Weber MM,Carlyon JA
A-6455 was used in Immunocytochemistry to advance knowledge of O. tsutsugamushi Ank functional domains and offer an approach for validating their roles in infection.
Thu May 19 00:00:00 UTC 2022
NanoTag Nanobody Tools for Drosophila In Vitro and In Vivo Studies.
Current protocols
Kim AR,Xu J,Cheloha R,Mohr SE,Zirin J,Ploegh HL,Perrimon N
A-6455 was used in Western Blot to produce nanobodies, visualize proteins of interest in either fixed or live samples, and tag endogenous proteins via CRISPR-mediated genome engineering.
Thu Dec 01 00:00:00 UTC 2022
Multi-Dimensional Spectral Single Molecule Localization Microscopy.
Frontiers in bioinformatics
Butler C,Saraceno GE,Kechkar A,Bénac N,Studer V,Dupuis JP,Groc L,Galland R,Sibarita JB
A-6455 was used in Immunocytochemistry to illustrate the capacity of our approach by performing multi-color 3D DNA-PAINT of fixed samples, and demonstrate simultaneous tracking of multiple receptors in live fibroblast and neuron cultures.
Fri Sep 06 00:00:00 UTC 2024
Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing.
Nature communications
Xue C,Salunkhe SJ,Tomimatsu N,Kawale AS,Kwon Y,Burma S,Sung P,Greene EC
A-6455 was used in Western Blot to demonstrate the role of bloom helicase in DNA repair.
Tue Apr 26 00:00:00 UTC 2022
A joint-ParB interface promotes Smc DNA recruitment.
Cell reports
Bock FP,Liu HW,Anchimiuk A,Diebold-Durand ML,Gruber S
A-6455 was used in Western Blot to find that ParB directly binds the Smc subunit.
Tue Aug 30 00:00:00 UTC 2022
Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Mitra S,Devi S,Lee MS,Jui J,Sahu A,Goldman D
A-6455 was used in Immunohistochemistry to report that MG-derived Vegfaa and Pgfa engage Flt1 and Kdrl receptors on VE cells to regulate MG gene expression, Notch signaling, proliferation, and neuronal regeneration.
Tue Dec 13 00:00:00 UTC 2022
Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development.
eLife
Ma J,Bi L,Spurlin J,Lwigale P
A-6455 was used in Immunohistochemistry to suggest that Npnt augments cell migration into the presumptive cornea extracellular matrix by functioning as a substrate for Itgα8-positive pNC cells.
Thu Mar 03 00:00:00 UTC 2022
Human-specific regulation of neural maturation identified by cross-primate transcriptomics.
Current biology : CB
Linker SB,Narvaiza I,Hsu JY,Wang M,Qiu F,Mendes APD,Oefner R,Kottilil K,Sharma A,Randolph-Moore L,Mejia E,Santos R,Marchetto MC,Gage FH
A-6455 was used in Immunocytochemistry-immunofluorescence to provide evidence for the divergence of gene regulation as a key molecular mechanism underlying human neoteny.
Mon Nov 21 00:00:00 UTC 2022
Herpesviruses assimilate kinesin to produce motorized viral particles.
Nature
Pegg CE,Zaichick SV,Bomba-Warczak E,Jovasevic V,Kim D,Kharkwal H,Wilson DW,Walsh D,Sollars PJ,Pickard GE,Savas JN,Smith GA
A-6455 was used in Immunoprecipitation to explain a critical component of the alphaherpesvirus neuroinvasive mechanism and demonstrate that these viruses assimilate a cellular protein as an essential proviral structural component.
Mon Nov 01 00:00:00 UTC 2021
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Cell stem cell
Breunig M,Merkle J,Wagner M,Melzer MK,Barth TFE,Engleitner T,Krumm J,Wiedenmann S,Cohrs CM,Perkhofer L,Jain G,Krüger J,Hermann PC,Schmid M,Madácsy T,Varga Á,Griger J,Azoitei N,Müller M,Wessely O,Robey PG,Heller S,Dantes Z,Reichert M,Günes C,Bolenz C,Kuhn F,Maléth J,Speier S,Liebau S,Sipos B,Kuster B,Seufferlein T,Rad R,Meier M,Hohwieler M,Kleger A
A-6455 was used in Flow cytometry/Cell sorting to show that PDLOs enable in vitro and in vivo studies of pancreatic plasticity, dysplasia, and cancer formation from a genetically defined background.
Thu Jun 03 00:00:00 UTC 2021
Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
The Journal of clinical investigation
Mishra S,Sadagopan N,Dunkerly-Eyring B,Rodriguez S,Sarver DC,Ceddia RP,Murphy SA,Knutsdottir H,Jani VP,Ashok D,Oeing CU,O'Rourke B,Gangoiti JA,Sears DD,Wong GW,Collins S,Kass DA
A-6455 was used in Western Blot to show that cyclic GMP-selective phosphodiesterase 9A inhibition (PDE9-I) in both male and ovariectomized female mice suppresses preestablished severe diet-induced obesity/CMS with or without superimposed mild cardiac pressure load.
Mon Nov 01 00:00:00 UTC 2021
Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety.
Neuron
Nguyen C,Mondoloni S,Le Borgne T,Centeno I,Come M,Jehl J,Solié C,Reynolds LM,Durand-de Cuttoli R,Tolu S,Valverde S,Didienne S,Hannesse B,Fiancette JF,Pons S,Maskos U,Deroche-Gamonet V,Dalkara D,Hardelin JP,Mourot A,Marti F,Faure P
A-6455 was used in Immunohistochemistry to define how the multiple effects of nicotine map onto dopamine cell diversity, and whether nAChR or other features can define different neuronal subpopulations that, through their response to nicotine, can influence specific behaviors such as anxiety.
Wed Aug 18 00:00:00 UTC 2021
Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain.
Molecular psychiatry
García-González D,Dumitru I,Zuccotti A,Yen TY,Herranz-Pérez V,Tan LL,Neitz A,García-Verdugo JM,Kuner R,Alfonso J,Monyer H
A-6455 was used in Immunohistochemistry to find that the number of newborn neurons in the NAc is dynamically regulated by persistent pain, suggesting that adult neurogenesis of MSNs is an experience-modulated process.
Wed Sep 01 00:00:00 UTC 2021
An integrative transcriptional logic model of hepatic insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America
Kitamoto T,Kuo T,Okabe A,Kaneda A,Accili D
A-6455 was used in Immunohistochemistry-immunofluorescence to investigate the hypothesis that genes in the lipid/lipoprotein pathway and those in the glucose metabolic pathway are governed by different transcriptional regulatory logics that affect their response to physiologic (fasting/refeeding) as well as pathophysiologic cues (insulin resistance and hyperglycemia).
Tue Nov 09 00:00:00 UTC 2021
Fast tuning of posture control by visual feedback underlies gaze stabilization in walking Drosophila.
Current biology : CB
Cruz TL,Pérez SM,Chiappe ME
A-6455 was used in Immunohistochemistry to study Drosophila processing of visual feedback in control of gaze during exploratory walking.
Mon Oct 25 00:00:00 UTC 2021
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
EMBO reports
Wang F,Chen X,Cheng H,Song L,Liu J,Caplan S,Zhu L,Wu JY
A-6455 was used in Immunocytochemistry to report that MICAL2PV is a novel tunneling nanotube (TNT) regulator that suppresses TNT formation and modulates mitochondrial distribution.
Mon Jul 05 00:00:00 UTC 2021
Associative Learning Requires Neurofibromin to Modulate GABAergic Inputs to Drosophila Mushroom Bodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Georganta EM,Moressis A,Skoulakis EMC
A-6455 was used in Immunohistochemistry to show that dNf1 (Drosophila melanogaster ortholog of Neurofibromin 1) loss results in excess GABAergic signaling to the central for associative learning mushroom body neurons, apparently suppressing learning.
Wed Jun 16 00:00:00 UTC 2021
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Frontiers in cell and developmental biology
Pérez-Moreno JJ,Santa-Cruz Mateos C,Martín-Bermudo MD,Estrada B
A-6455 was used in Immunohistochemistry to uncover a new role for the interaction between laminins and Kon-tiki/Perdido during Drosophila myogenesis.
Sat Jul 16 00:00:00 UTC 2022
The nuclear activity of the actin-binding Moesin protein is necessary for gene expression in Drosophila.
The FEBS journal
Bajusz C,Kristó I,Abonyi C,Venit T,Vedelek V,Lukácsovich T,Farkas A,Borkúti P,Kovács Z,Bajusz I,Marton A,Vizler C,Lipinszki Z,Sinka R,Percipalle P,Vilmos P
A-6455 was used in Immunohistochemistry to reveal that in Drosophila the expression of protein chaperones requires the nuclear functions of Moesin.
Sun Aug 01 00:00:00 UTC 2021
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Neuropharmacology
Nuwer JL,Brady ML,Povysheva NV,Coyne A,Jacob TC
A-6455 was used in Immunocytochemistry to show that α5-GABAARs contribute to dendritic spine maturation and excitatory synapse development via a NMDAR dependent mechanism without perturbing overall neuronal excitability.
Fri Oct 01 00:00:00 UTC 2021
Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function.
Journal of cell science
Kliment CR,Nguyen JMK,Kaltreider MJ,Lu Y,Claypool SM,Radder JE,Sciurba FC,Zhang Y,Gregory AD,Iglesias PA,Sidhaye VK,Robinson DN
A-6455 was used in Western Blot to highlights a potential for upregulation of ANT proteins and/or of their agonists in the protection from dysfunctional mitochondrial metabolism, airway hydration and ciliary motility in COPD.
Thu Feb 25 00:00:00 UTC 2021
Orbit/CLASP determines centriole length by antagonising Klp10A in Drosophila spermatocytes.
Journal of cell science
Shoda T,Yamazoe K,Tanaka Y,Asano Y,Inoue YH
A-6455 was used in Proximity Ligation Assay (PLA) to understand the regulatory mechanism.
Fri Mar 26 00:00:00 UTC 2021
Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice.
Endocrinology
Gonzalez IE,Ramirez-Matias J,Lu C,Pan W,Zhu A,Myers MG,Olson DP
A-6455 was used in Immunohistochemistry to characterize the contribution of calcitonin receptor-expressing PVH neurons (CalcRPVH) to energy balance control.
Tue Jun 01 00:00:00 UTC 2021
Structural basis of the human Scribble-Vangl2 association in health and disease.
The Biochemical journal
How JY,Stephens RK,Lim KYB,Humbert PO,Kvansakul M
A-6455 was used in Western Blot to study the oncogenic and tumour suppressor functions of the Scribble-Vangl2 complex.
Fri Apr 16 00:00:00 UTC 2021
Proximity-based proteomics reveals the thylakoid lumen proteome in the cyanobacterium Synechococcus sp. PCC 7002.
Photosynthesis research
Dahlgren KK,Gates C,Lee T,Cameron JC
A-6455 was used in Western Blotting to demonstrate the power of APEX2 as a tool to study the cell biology of intracellular features and processes, including photosystem II assembly in cyanobacteria, with enhanced spatiotemporal resolution.
Mon Feb 01 00:00:00 UTC 2021
Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
Biochemical and biophysical research communications
Kato K,Ikliptikawati DK,Kobayashi A,Kondo H,Lim K,Hazawa M,Wong RW
A-6455 was used in Immunocytochemistry-immunoflourescence to demonstrate that the open-reading frame 6 (ORF6) of SARS-CoV-2 can directly manipulate localization and functions of nucleoporins.
Fri Jan 15 00:00:00 UTC 2021
Masculinized Drosophila females adapt their fighting strategies to their opponent.
The Journal of experimental biology
Monyak RE,Golbari NM,Chan YB,Pranevicius A,Tang G,Fernández MP,Kravitz EA
A-6455 was used in Immunohistochemistry to study sexually dimorphic behaviour between male and female Drosophila.
Thu Mar 25 00:00:00 UTC 2021
Early cis-regulatory events in the formation of retinal horizontal cells.
Developmental biology
Schick E,Gonzalez KC,Dutta P,Hossain K,Ghinia Tegla MG,Emerson MM
A-6455 was used in Immunohistochemistry to describe a screen for cis-regulatory elements, or enhancers, for the horizontal cell-associated genes PTF1A, ONECUT1 (OC1), TFAP2A (AP2A), and LHX1. The OC1ECR22 and Tfap2aACR5 elements were shown to be potential enhancers for OC1 and TFAP2A, respectively, and to be specifically active in developing horizontal cells.
Sun Aug 01 00:00:00 UTC 2021
KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.
Journal of hematology & oncology
Lee JW,Hur J,Kwon YW,Chae CW,Choi JI,Hwang I,Yun JY,Kang JA,Choi YE,Kim YH,Lee SE,Lee C,Jo DH,Seok H,Cho BS,Baek SH,Kim HS
A-6455 was used in Immunohistochemistry to find that Kai1 knockout mice showed significantly enhanced angiogenesis, going on to investigate the anti-angiogenic roll of Kai1 in vitro and in vivo.
Thu Sep 16 00:00:00 UTC 2021
DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.
eLife
Morcom L,Edwards TJ,Rider E,Jones-Davis D,Lim JW,Chen KS,Dean RJ,Bunt J,Ye Y,Gobius I,Suárez R,Mandelstam S,Sherr EH,Richards LJ
A-6455 was used in Western Blot to identify an eight base-pair deletion in Draxin and misregulated astroglial and leptomeningeal proliferation as genetic and cellular factors for variable IHF remodelling and CCD in BTBR strains.
Tue May 04 00:00:00 UTC 2021
Temperature and species-dependent regulation of browning in retrobulbar fat.
Scientific reports
Rajaii F,Kim DW,Pan J,Mahoney NR,Eberhart CG,Qian J,Blackshaw S
A-6455 was used in Immunohistochemistry to study the developmental origins of murine retrobulbar fat and transcriptionally profile retrobulbar fat in mice and humans.
Thu Feb 04 00:00:00 UTC 2021
Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila.
Brain communications
Bridi JC,Bereczki E,Smith SK,Poças GM,Kottler B,Domingos PM,Elliott CJ,Aarsland D,Hirth F
A-6455 was used in Western Blot, Immunohistochemistry to investigate the cascade of pathological events underlying α-syn accumulation and toxicity in a Drosophila model of synucleinopathy by employing a combination of histological, biochemical, behavioural and electrophysiological assays.
Tue Apr 02 00:00:00 UTC 2024
Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila.
Brain communications
Bridi JC,Bereczki E,Smith SK,Poças GM,Kottler B,Domingos PM,Elliott CJ,Aarsland D,Hirth F
A-6455 was used in Western Blot, Immunohistochemistry to investigate the cascade of pathological events underlying α-syn accumulation and toxicity in a Drosophila model of synucleinopathy by employing a combination of histological, biochemical, behavioural and electrophysiological assays.
Tue Apr 02 00:00:00 UTC 2024
Analysis of Orientia tsutsugamushi promoter activity.
Pathogens and disease
Hunt JR,Carlyon JA
A-6455 was used in Western Blotting to examine the untranslated regions upstream of O. tsutsugamushi genes encoding outer membrane protein A (ompA), 22-kDa type-specific antigen (tsa22) and tsa56.
Thu Sep 23 00:00:00 UTC 2021
Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states.
Scientific reports
Chen X,Emerson MM
A-6455 was used in Immunohistochemistry to suggest that the role of Notch signaling in cone photoreceptor formation and proliferation are both mediated by a localized function of Notch in multipotent retinal progenitor cells to repress the formation of restricted progenitor cells.
Thu Jul 15 00:00:00 UTC 2021
The role of Ire1 in Drosophila eye pigmentation revealed by an RNase dead allele.
Developmental biology
Mitra S,Ryoo HD
A-6455 was used in Immunohistochemistry to indicate that the loss of Ire1, which would impair ER homeostasis, also results in altered adult eye pigmentation.
Fri Oct 01 00:00:00 UTC 2021
Fibroblast fusion to the muscle fiber regulates myotendinous junction formation.
Nature communications
Yaseen W,Kraft-Sheleg O,Zaffryar-Eilot S,Melamed S,Sun C,Millay DP,Hasson P
A-6455 was used in Immunohistochemistry to identify fibroblasts that have switched on a myogenic program and demonstrate these dual identity cells fuse into the developing muscle fibers along the MTJs facilitating the introduction of fibroblast-specific transcripts into the elongating myofibers.
Tue Jun 22 00:00:00 UTC 2021
Autophagy Receptor Protein Tax1-Binding Protein 1/TRAF6-Binding Protein Is a Cellular Substrate of Enteroviral Proteinase.
Frontiers in microbiology
Mohamud Y,Xue YC,Liu H,Ng CS,Bahreyni A,Luo H
A-6455 was used in Western Blot to explore the effects enterovirus-induced diversion of autophagy on organelle quality control.
Tue Jun 22 00:00:00 UTC 2021
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Communications biology
Vignoli B,Sansevero G,Sasi M,Rimondini R,Blum R,Bonaldo V,Biasini E,Santi S,Berardi N,Lu B,Canossa M
A-6455 was used in Immunohistochemistry to demonstrate that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor (proBDNF) into active prodomain (BDNFpro) and mature BDNF (mBDNF) for synaptic re-use.
Tue Oct 05 00:00:00 UTC 2021
Basal Forebrain Cholinergic Neurons Selectively Drive Coordinated Motor Learning in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Li Y,Hollis E
A-6455 was used in Immunohistochemistry to identify a role for the baso-cortical cholinergic pathway in the acquisition of a coordinated motor skill in mice.
Wed Dec 08 00:00:00 UTC 2021
Tumor-induced disruption of the blood-brain barrier promotes host death.
Developmental cell
Kim J,Chuang HC,Wolf NK,Nicolai CJ,Raulet DH,Saijo K,Bilder D
A-6455 was used in Immunohistochemistry to conclude that BBB alterations constitute a conserved lethal tumor-host interaction that also underlies other physiological morbidities.
Mon Oct 11 00:00:00 UTC 2021
The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture.
International journal of molecular sciences
Bustamante-Jaramillo LF,Ramos C,Martín-Castellanos C
A-6455 was used in Immunoprecipitation to conclude that Crs1 displays multiple functions, acting both in cell cycle progression and in several key meiosis-specific events.
Sat May 22 00:00:00 UTC 2021
Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature.
Frontiers in neuroscience
Harding EC,Ba W,Zahir R,Yu X,Yustos R,Hsieh B,Lignos L,Vyssotski AL,Merkle FT,Constandinou TG,Franks NP,Wisden W
A-6455 was used in Immunohistochemistry to show that nitric oxide synthase (NOS1) neurons in median and medial preoptic hypothalamus are predominantly NREM and REM active, especially at the boundary of wake to NREM transitions, and in the later parts of REM bouts, with lower activity during wakefulness.
Wed May 08 00:00:00 UTC 2024
Myelinosome Organelles in the Retina of R6/1 Huntington Disease (HD) Mice: Ubiquitous Distribution and Possible Role in Disease Spreading.
International journal of molecular sciences
Yefimova MG,Béré E,Cantereau-Becq A,Meunier-Balandre AC,Merceron B,Burel A,Merienne K,Ravel C,Becq F,Bourmeyster N
A-6455 was used in Immunocytochemistry-immunofluorescence to conclude that incorporation of myelinosomes carrying mHTT-exon1 in recipient cells may contribute to Huntington disease (HD) spreading in the retina.
Thu Nov 25 00:00:00 UTC 2021
Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.
BMC biology
Ofek S,Wiszniak S,Kagan S,Tondl M,Schwarz Q,Kalcheim C
A-6455 was used in Immunohistochemistry (Paraffin) to to offer a new resource for defining specific cell types, and provide evidence that Notch is required to establish the definitive RP, and to determine the choice between RP and interneuron fates, but not the segregation of RP from NC.
Fri Apr 23 00:00:00 UTC 2021
Laminar-specific cortico-cortical loops in mouse visual cortex.
eLife
Young H,Belbut B,Baeta M,Petreanu L
A-6455 was used in Immunohistochemistry to reveal that CC connections are selectively wired to form monosynaptic excitatory loops and support a differential role of supragranular and infragranular neurons in hierarchical recurrent computations.
Mon Feb 01 00:00:00 UTC 2021
Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.
Genes to cells : devoted to molecular & cellular mechanisms
Kamemura K,Chen CA,Okumura M,Miura M,Chihara T
A-6455 was used in Immunohistochemistry to suggest that synaptic protein localization and ER quality control may be affected by disease mutations.
Thu Apr 01 00:00:00 UTC 2021
Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.
PLoS genetics
Yuen AC,Hillion KH,Wang R,Amoyel M
A-6455 was used in Immunohistochemistry to understand how cyst cell differentiation is regulated by addressing the role of PI3K/Tor signalling in cyst cells.
Wed Dec 01 00:00:00 UTC 2021
Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin.
Current biology : CB
Hotta T,Haynes SE,Blasius TL,Gebbie M,Eberhardt EL,Sept D,Cianfrocco M,Verhey KJ,Nesvizhskii AI,Ohi R
A-6455 was used in Western Blotting to support the notion that parthenolide is a promiscuous inhibitor of many cellular processes and suggest that its ability to block detyrosination may be an indirect consequence of reducing the polymerization-competent pool of tubulin in cells.
Mon Feb 22 00:00:00 UTC 2021
Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.
Small GTPases
Tong SJ,Wall AA,Hung Y,Luo L,Stow JL
A-6455 was used in Western Blotting to show that Rab8a is activated by multiple TLRs and regulates downstream Akt/mTOR signalling by recruiting the effector PI3Kγ, but the guanine nucleotide exchange factors (GEF) canonically required for Rab8a activation in TLR pathways is not known.
Fri Jan 01 00:00:00 UTC 2021
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
A-6455 was used in Immunohistochemistry to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 UTC 2021
Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
Cell reports
Yoo ES,Li L,Jia L,Lord CC,Lee CE,Birnbaum SG,Vianna CR,Berglund ED,Cunningham KA,Xu Y,Sohn JW,Liu C
A-6455 was used in Immunohistochemistry-immunofluorescence to find that Htr2c acts in neurons to counteract the anorectic effect of serotonergic appetite suppressants.
Tue Nov 16 00:00:00 UTC 2021
Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.
eLife
Xu X,Masubuchi T,Cai Q,Zhao Y,Hui E
A-6455 was used in Western Blotting to provide a molecular interpretation of the SHP1/SHP2-binding specificities of PD-1 and BTLA, with implications for the mechanisms of a large family of therapeutically relevant receptors.
Thu Nov 04 00:00:00 UTC 2021
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Circulation
Edgar L,Akbar N,Braithwaite AT,Krausgruber T,Gallart-Ayala H,Bailey J,Corbin AL,Khoyratty TE,Chai JT,Alkhalil M,Rendeiro AF,Ziberna K,Arya R,Cahill TJ,Bock C,Laurencikiene J,Crabtree MJ,Lemieux ME,Riksen NP,Netea MG,Wheelock CE,Channon KM,Rydén M,Udalova IA,Carnicer R,Choudhury RP
A-6455 was used in Immunohistochemistry to test the hypothesis that hyperglycemia induces trained immunity in macrophages, promoting persistent proatherogenic characteristics.
Tue Sep 21 00:00:00 UTC 2021
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Nature communications
Yamamoto Y,Chino H,Tsukamoto S,Ode KL,Ueda HR,Mizushima N
A-6455 was used in Western Blot to suggest that NEK9 regulates ciliogenesis by acting as an autophagy adaptor for MYH9.
Wed Jun 02 00:00:00 UTC 2021
Protocerebral Bridge Neurons That Regulate Sleep in Drosophila melanogaster.
Frontiers in neuroscience
Tomita J,Ban G,Kato YS,Kume K
A-6455 was used in Immunohistochemistry to show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons with R52B10-Gal4 promoted sleep and wakefulness, respectively.
Tue Nov 02 00:00:00 UTC 2021
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice.
Nature communications
Dongelmans M,Durand-de Cuttoli R,Nguyen C,Come M,Duranté EK,Lemoine D,Brito R,Ahmed Yahia T,Mondoloni S,Didienne S,Bousseyrol E,Hannesse B,Reynolds LM,Torquet N,Dalkara D,Marti F,Mourot A,Naudé J,Faure P
A-6455 was used in Immunohistochemistry to investigate the effect of chronic nicotine on midbrain dopamine neurone activity and its consequence on the trade-off between exploitation and exploration.
Fri Nov 26 00:00:00 UTC 2021
Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor survival.
PLoS genetics
Huang HW,Ryoo HD
A-6455 was used in Immunohistochemistry to reveal a previously unrecognized link between light-dependent Rh1 proteostasis and the ER-stress imposing ninaEG69D mutant that cause retinal degeneration.
Fri Oct 01 00:00:00 UTC 2021
Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CLpro Inhibitors.
Viruses
Rawson JMO,Duchon A,Nikolaitchik OA,Pathak VK,Hu WS
A-6455 was used in Western Blot to develop a novel cell-based luciferase complementation reporter assay to identify inhibitors of SARS-CoV-2 3C-like protease in a BSL-2 setting.
Sun Jan 24 00:00:00 UTC 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.
PLoS genetics
Girard V,Jollivet F,Knittelfelder O,Celle M,Arsac JN,Chatelain G,Van den Brink DM,Baron T,Shevchenko A,Kühnlein RP,Davoust N,Mollereau B
A-6455 was used in Immunohistochemistry to propose that αSyn cooperates with LD proteins to inhibit lipolysis and that binding of αSyn to LDs contributes to the pathogenic misfolding and aggregation of αSyn in neurons.
Mon Nov 01 00:00:00 UTC 2021
The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages.
Traffic (Copenhagen, Denmark)
West ZE,Aitcheson SM,Semmler ABT,Murray RZ
A-6455 was used in Western Blotting to suggest that Stx6/Stx7/Vti1b is a key Q-SNARE complex in macrophages during an immune response and in partnership with VAMP4 it regulates transport of newly made MT1-MMP.
Mon Nov 01 00:00:00 UTC 2021
NO-mediated signal transmission in bladder vasculature as a therapeutic target of PDE5 inhibitors. Rodent model studies.
British journal of pharmacology
Tanaka H,Mitsui R,Oishi M,Passlick S,Jabs R,Steinhäuser C,Tanaka KF,Hashitani H
A-6455 was used in Immunohistochemistry-immunofluorescence to show that the NO-mediated signal transmission is a potential target for PDE5 inhibitor therapy in bladder dysfunctions.
Mon Mar 01 00:00:00 UTC 2021
Homozygote loss-of-function variants in the human COCH gene underlie hearing loss.
European journal of human genetics : EJHG
Danial-Farran N,Chervinsky E,Nadar-Ponniah PT,Cohen Barak E,Taiber S,Khayat M,Avraham KB,Shalev SA
A-6455 was used in Western Blotting to indicate a LOF effect of the variant and a major decrease in cochlin translation.
Mon Feb 01 00:00:00 UTC 2021
Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil.
Nature communications
Pogodalla N,Kranenburg H,Rey S,Rodrigues S,Cardona A,Klämbt C
A-6455 was used in Immunohistochemistry to conclude that polarized glia compartmentalizes the brain and is essential for proper nervous system function.
Thu Nov 04 00:00:00 UTC 2021
Role of Hakai in m6A modification pathway in Drosophila.
Nature communications
Wang Y,Zhang L,Ren H,Ma L,Guo J,Mao D,Lu Z,Lu L,Yan D
A-6455 was used in Western Blot to provide insights into how Sxl cooperate with the m6A pathway to control its own splicing.
Mon Apr 12 00:00:00 UTC 2021
Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development.
Biology open
Marcetteau J,Matusek T,Luton F,Thérond PP
A-6455 was used in Immunohistochemistry to analyse the consequence of the absence of Arf6 activity on Drosophila wing patterning.
Wed Dec 01 00:00:00 UTC 2021
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.
Nature communications
Schweizer N,Haren L,Dutto I,Viais R,Lacasa C,Merdes A,Lüders J
A-6455 was used in Immunocytochemistry to identify a non-canonical role of augmin-γTuRC in the centriole lumen that is linked to human disease (microcephaly with chorioretinopathy).
Fri Oct 15 00:00:00 UTC 2021
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.
Nature communications
Xu X,Ni K,He Y,Ren J,Sun C,Liu Y,Aladjem MI,Burkett S,Finney R,Ding X,Sharan SK,Muegge K
A-6455 was used in Western Blot to demonstrate the pathogenic effects of LSH depletion: a causative mutation of Immunodeficiency Centromeric Instability Facial Anomalies 4 syndrome.
Thu Jun 10 00:00:00 UTC 2021
Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production.
Cell death & disease
Zhuravleva V,Vaz-Silva J,Zhu M,Gomes P,Silva JM,Sousa N,Sotiropoulos I,Waites CL
A-6455 was used in Western Blotting to identify Rab35 as a key regulator of APP processing and suggest that its downregulation may contribute to stress-related and AD-related amyloidogenesis.
Wed Dec 08 00:00:00 UTC 2021
Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain.
Frontiers in endocrinology
Khant Aung Z,Kokay IC,Grattan DR,Ladyman SR
A-6455 was used in Immunohistochemistry to examine the relative contribution of prolactin action in the pancreas and brain to these pregnancy-induced adaptations in glucose regulation.
Thu Feb 17 00:00:00 UTC 2022
RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis.
Cell
Rheinemann L,Downhour DM,Bredbenner K,Mercenne G,Davenport KA,Schmitt PT,Necessary CR,McCullough J,Schmitt AP,Simon SM,Sundquist WI,Elde NC
A-6455 was used in Western Blotting to describe duplicated and truncated copies of the ESCRT-III factor CHMP3 that block ESCRT-dependent virus budding and arose independently in New World monkeys and mice.
Thu Oct 14 00:00:00 UTC 2021
A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation.
Cell
Stagkourakis S,Smiley KO,Williams P,Kakadellis S,Ziegler K,Bakker J,Brown RSE,Harkany T,Grattan DR,Broberger C
A-6455 was used in Immunohistochemistry to identify a frequency-tuned brain-endocrine-brain circuit that can act as a gain control system determining a species' parental strategy.
Thu Aug 20 00:00:00 UTC 2020
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.
Cell metabolism
Mukherjee C,Kling T,Russo B,Miebach K,Kess E,Schifferer M,Pedro LD,Weikert U,Fard MK,Kannaiyan N,Rossner M,Aicher ML,Goebbels S,Nave KA,Krämer-Albers EM,Schneider A,Simons M
A-6455 was used in Western Blot to identify glial molecules providing vital functions to neurons.
Tue Aug 04 00:00:00 UTC 2020
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury.
Cell stem cell
Ceto S,Sekiguchi KJ,Takashima Y,Nimmerjahn A,Tuszynski MH
A-6455 was used in Immunocytochemistry to determine if and how grafts become synaptically organized and connect with host systems.
Thu Sep 03 00:00:00 UTC 2020
Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.
Science translational medicine
La Montanara P,Hervera A,Baltussen LL,Hutson TH,Palmisano I,De Virgiliis F,Kong G,Chadwick J,Gao Y,Bartus K,Majid QA,Gorgoraptis N,Wong K,Downs J,Pizzorusso T,Ultanir SK,Leonard H,Yu H,Millar DS,Istvan N,Mazarakis ND,Di Giovanni S
A-6455 was used in Immunocytochemistry to unveil a previously unrecognized role for CDKL5 in nociception, proposing an original regulatory mechanism for pain perception with implications for future therapeutics in CDKL5 deficiency disorder.
Wed Jul 08 00:00:00 UTC 2020
Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species.
Nucleic acids research
He X,Chen W,Liu Z,Yu G,Chen Y,Cai YJ,Sun L,Xu W,Zhong L,Gao C,Chen J,Zhang M,Yang S,Yao Y,Zhang Z,Ma F,Zhang CC,Lu HP,Yu B,Cheng TL,Qiu J,Sheng Q,Zhou HM,Lv ZR,Yan J,Zhou Y,Qiu Z,Cui Z,Zhang X,Meng A,Sun Q,Yang Y
A-6455 was used in Western Blotting to develop an efficient and low-risk gene editing method.
Thu Jun 04 00:00:00 UTC 2020
SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies.
Nucleic acids research
Toki N,Takahashi H,Sharma H,Valentine MNZ,Rahman FM,Zucchelli S,Gustincich S,Carninci P
A-6455 was used in Western Blotting to investigate the target mRNAs and long non-coding RNAs (lncRNAs) with SINE element (SINEUP RNAs) network of translational regulation.
Wed Nov 18 00:00:00 UTC 2020
An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs.
Nucleic acids research
Ohyama T,Takahashi H,Sharma H,Yamazaki T,Gustincich S,Ishii Y,Carninci P
A-6455 was used in Western Blotting to identify a structured domain in nucleotides 31-119 of the inverted SINE B2.
Fri Sep 18 00:00:00 UTC 2020
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Neuron
Jiang H,Gallet S,Klemm P,Scholl P,Folz-Donahue K,Altmüller J,Alber J,Heilinger C,Kukat C,Loyens A,Müller-Fielitz H,Sundaram S,Schwaninger M,Prevot V,Brüning JC
A-6455 was used in Immunocytochemistry to reveal that MCH neurons directly regulate permeability of the ME barrier, linking the activity of energy state and sleep regulatory neurons to the regulation of hormone accessibility to the ARC.
Wed Jul 22 00:00:00 UTC 2020
Visualization of a Distributed Synaptic Memory Code in the Drosophila Brain.
Neuron
Bilz F,Geurten BRH,Hancock CE,Widmann A,Fiala A
A-6455 was used in Immunohistochemistry to reveal that synaptic boutons rather than cells act as individually modifiable units, and coherence among them is a memory-encoding parameter.
Wed Jun 17 00:00:00 UTC 2020
Structural and functional characterization of the bestrophin-2 anion channel.
Nature structural & molecular biology
Owji AP,Zhao Q,Ji C,Kittredge A,Hopiavuori A,Fu Z,Ward N,Clarke OB,Shen Y,Zhang Y,Hendrickson WA,Yang T
A-6455 was used in Western Blotting to report cryo-EM structures of bovine bestrophin-2 (bBest2) bound and unbound by Ca2+ at 2.4- and 2.2-Å resolution, respectively.
Wed Apr 01 00:00:00 UTC 2020
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases.
The Journal of experimental medicine
Mailhot B,Christin M,Tessandier N,Sotoudeh C,Bretheau F,Turmel R,Pellerin È,Wang F,Bories C,Joly-Beauparlant C,De Koninck Y,Droit A,Cicchetti F,Scherrer G,Boilard E,Sharif-Naeini R,Lacroix S
A-6455 was used in Immunohistochemistry to reveal that neuronal IL-1R1 signaling mediates pain, uncovering the potential benefit of anti-IL-1 therapies for pain management in patients with chronic inflammatory diseases. © 2020 Mailhot et al.
Mon Sep 07 00:00:00 UTC 2020
Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.
The EMBO journal
González-Méndez L,Gradilla AC,Sánchez-Hernández D,González E,Aguirre-Tamaral A,Jiménez-Jiménez C,Guerra M,Aguilar G,Andrés G,Falcón-Pérez JM,Guerrero I
A-6455 was used in Immunohistochemistry to show that a vesicle fusion mechanism mediated by SNARE proteins is required for Ptc placement at contact sites.
Tue Jun 02 00:00:00 UTC 2020
Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance.
The EMBO journal
Naso F,Intartaglia D,Falanga D,Soldati C,Polishchuk E,Giamundo G,Tiberi P,Marrocco E,Scudieri P,Di Malta C,Trapani I,Nusco E,Salierno FG,Surace EM,Galietta LJ,Banfi S,Auricchio A,Ballabio A,Medina DL,Conte I
A-6455 was used in Immunocytochemistry to show that the light-responsive miR-211 controls lysosomal biogenesis at the beginning of light-dark transitions in the RPE by targeting Ezrin, a cytoskeleton-associated protein essential for the regulation of calcium homeostasis.
Wed Apr 15 00:00:00 UTC 2020
Hedgehog Signaling Regulates Epithelial Morphogenesis to Position the Ventral Embryonic Midline.
Developmental cell
Arraf AA,Yelin R,Reshef I,Jadon J,Abboud M,Zaher M,Schneider J,Vladimirov FK,Schultheiss TM
A-6455 was used in Immunohistochemistry to investigate if there is a role for Hedgehog signaling in regulating epithelial morphology and provide an example of how transcellular signaling can modulate specific cellular processes to shape tissue morphogenesis.
Mon Jun 08 00:00:00 UTC 2020
Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres.
Genes & development
Loe TK,Li JSZ,Zhang Y,Azeroglu B,Boddy MN,Denchi EL
A-6455 was used in Immunocytochemistry-Immunofluorescence to define the function of alternative lengthening of telomeres(ALT)-associated PML bodies (APBs) in ALT using CRISPR/Cas9 to delete PML and APB components from ALT-positive cells.
Fri May 01 00:00:00 UTC 2020
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage.
Proceedings of the National Academy of Sciences of the United States of America
Mauceri D,Buchthal B,Hemstedt TJ,Weiss U,Klein CD,Bading H
A-6455 was used in Western Blotting to show that stimulation of eNMDARs causes a rapid shutoff of VEGFD expression, leading to a dramatic loss of dendritic structures.
Tue Apr 14 00:00:00 UTC 2020
Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.
Current biology : CB
Grippo RM,Tang Q,Zhang Q,Chadwick SR,Gao Y,Altherr EB,Sipe L,Purohit AM,Purohit NM,Sunkara MD,Cios KJ,Sidikpramana M,Spano AJ,Campbell JN,Steele AD,Hirsh J,Deppmann CD,Wu M,Scott MM,Güler AD
A-6455 was used in Immunohistochemistry to demonstrate that dopaminergic signaling within the suprachiasmatic nucleus (SCN), the central circadian pacemaker, disrupts the timing of feeding, resulting in overconsumption of food.
Mon Jan 20 00:00:00 UTC 2020
The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster.
Current biology : CB
Imura E,Shimada-Niwa Y,Nishimura T,Hückesfeld S,Schlegel P,Ohhara Y,Kondo S,Tanimoto H,Cardona A,Pankratz MJ,Niwa R
A-6455 was used in Immunohistochemistry to suggest that the Crz-PTTH neuronal axis modulates ecdysteroid biosynthesis in response to octopamine, uncovering a regulatory neuroendocrine system in the developmental transition from growth to maturation.
Mon Jun 08 00:00:00 UTC 2020
Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment.
Current biology : CB
Fernandez MP,Pettibone HL,Bogart JT,Roell CJ,Davey CE,Pranevicius A,Huynh KV,Lennox SM,Kostadinov BS,Shafer OT
A-6455 was used in Immunohistochemistry to support an alternative model: structural plasticity in critical clock neurons is the basis for proper integration of light and temperature and gates sensory inputs into circadian clock neuron networks.
Mon Jun 22 00:00:00 UTC 2020
The Arabidopsis Nα -acetyltransferase NAA60 locates to the plasma membrane and is vital for the high salt stress response.
The New phytologist
Linster E,Layer D,Bienvenut WV,Dinh TV,Weyer FA,Leemhuis W,Brünje A,Hoffrichter M,Miklankova P,Kopp J,Lapouge K,Sindlinger J,Schwarzer D,Meinnel T,Finkemeier I,Giglione C,Hell R,Sinning I,Wirtz M
A-6455 was used in Western Blot to identify and characterize the first plasma membrane-anchored post-translationally acting N-acetyltransferase AtNAA60 in the reference plant Arabidopsis thaliana.
Thu Oct 01 00:00:00 UTC 2020
Opioids differentially modulate two synapses important for pain processing in the amygdala.
British journal of pharmacology
Kissiwaa SA,Patel SD,Winters BL,Bagley EE
A-6455 was used in Immunohistochemistry to show that µ-receptor agonists, such as morphine, will inhibit glutamate release from PB and BLA in the CeLC.
Wed Jan 01 00:00:00 UTC 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
A-6455 was used in Western Blotting to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 UTC 2020
Functional Analysis of the Plant Chromosomal Passenger Complex.
Plant physiology
Komaki S,Takeuchi H,Hamamura Y,Heese M,Hashimoto T,Schnittger A
A-6455 was used in Immunoprecipitation to identify and functionally characterize a Borealin homolog, BOREALIN RELATED (BORR), in Arabidopsis.
Sat Aug 01 00:00:00 UTC 2020
The Arabidopsis transcription factor AINTEGUMENTA orchestrates patterning genes and auxin signaling in the establishment of floral growth and form.
The Plant journal : for cell and molecular biology
Krizek BA,Blakley IC,Ho YY,Freese N,Loraine AE
A-6455 was used in Chromatin immunoprecipitation to reveal new features of the ANT transcriptional network by linking ANT to previously unknown regulatory targets.
Wed Jul 01 00:00:00 UTC 2020
Correction: Perturbation of canonical and non-canonical BMP signaling affects migration, polarity and dendritogenesis of mouse cortical neurons (doi:10.1242/dev.147157).
Development (Cambridge, England)
Saxena M,Agnihotri N,Sen J
A-6455 was used in Immunohistochemistry to investigate the role of Bone morphogenetic protein (BMP) signaling in other aspects of cortical development in vivo.
Thu Jan 23 00:00:00 UTC 2020
Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome.
Development (Cambridge, England)
Kahane N,Kalcheim C
A-6455 was used in Immunohistochemistry to reveal that the sclerotome is a potential site of a Shh gradient that coordinates the development of mesodermal and neural progenitors.
Tue May 26 00:00:00 UTC 2020
Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut.
Development (Cambridge, England)
Tamamouna V,Panagi M,Theophanous A,Demosthenous M,Michail M,Papadopoulou M,Teloni S,Pitsouli C,Apidianakis Y
A-6455 was used in Immunohistochemistry to study the role of tissue-intrinsic regenerative signaling in stem cell mitosis of adult Drosophila midgut of different genetic backgrounds.
Mon Jun 08 00:00:00 UTC 2020
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bikbaev A,Ciuraszkiewicz-Wojciech A,Heck J,Klatt O,Freund R,Mitlöhner J,Enrile Lacalle S,Sun M,Repetto D,Frischknecht R,Ablinger C,Rohlmann A,Missler M,Obermair GJ,Di Biase V,Heine M
A-6455 was used in Immunocytochemistry-immunoflourescence to propose that formation of connectivity in neuronal networks is associated with a concerted interplay of α2δ1 and α2δ3 subunits of calcium channels.
Wed Jun 17 00:00:00 UTC 2020
Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hu C,Kanellopoulos AK,Richter M,Petersen M,Konietzny A,Tenedini FM,Hoyer N,Cheng L,Poon CLC,Harvey KF,Windhorst S,Parrish JZ,Mikhaylova M,Bagni C,Calderon de Anda F,Soba P
A-6455 was used in Immunohistochemistry to provide evidence for a conserved role of Tao kinase in dendritic development and function of sensory neurons, suggesting that aberrant sensory function might be a common feature of ASDs.
Wed Feb 26 00:00:00 UTC 2020
EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Machado NLS,Bandaru SS,Abbott SBG,Saper CB
A-6455 was used in Immunohistochemistry to demonstrate that excitatory MnPO neurons mediate fever and examine a potential central circuit underlying the development of fever responses.
Wed Mar 18 00:00:00 UTC 2020
Subcellular Localization of Rice Acyl-CoA-Binding Proteins ACBP4 and ACBP5 Supports Their Non-redundant Roles in Lipid Metabolism.
Frontiers in plant science
Liao P,Leung KP,Lung SC,Panthapulakkal Narayanan S,Jiang L,Chye ML
A-6455 was used in Western Blot to suggest that OsACBP4 is likely involved in the intracellular shuttling of acyl-CoA esters and/or other lipids between the plasma membrane and the ER, while OsACBP5 appears to participate in the extracellular transport of acyl-CoA esters and/or other lipids, suggesting that they are non-redundant proteins in lipid trafficking.
Mon Sep 28 00:00:00 UTC 2020
Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer.
Molecular therapy oncolytics
Jung M,Yang Y,McCloskey JE,Zaman M,Vedvyas Y,Zhang X,Stefanova D,Gray KD,Min IM,Zarnegar R,Choi YY,Cheong JH,Noh SH,Rha SY,Chung HC,Jin MM
A-6455 was used in Immunohistochemistry to demonstrate that ICAM-1-targeting CAR T cells alone or in combination with chemotherapy represent a promising strategy to treat patients with ICAM-1+ advanced gastric cancer.
Fri Sep 25 00:00:00 UTC 2020
Scratch2, a Snail Superfamily Member, Is Regulated by miR-125b.
Frontiers in cell and developmental biology
Goes CP,Vieceli FM,De La Cruz SM,Simões-Costa M,Yan CYI
A-6455 was used in Immunohistochemistry to investigate the role of microRNAs (miRNAs) in the Scrt2 post-transcriptional regulatory mechanism.
Thu Oct 01 00:00:00 UTC 2020
A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors.
Disease models & mechanisms
Bajpai A,Quazi TA,Tang HW,Manzar N,Singh V,Thakur A,Ateeq B,Perrimon N,Sinha P
A-6455 was used in Immunoprecipitation to show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult Drosophila midgut.
Thu Jul 23 00:00:00 UTC 2020
Absence of p.R50X Pygm read-through in McArdle disease cellular models.
Disease models & mechanisms
Tarrasó G,Real-Martinez A,Parés M,Romero-Cortadellas L,Puigros L,Moya L,de Luna N,Brull A,Martín MA,Arenas J,Lucia A,Andreu AL,Barquinero J,Vissing J,Krag TO,Pinós T
A-6455 was used in Western Blot to report the absence of Pygm p.R50X readthrough induction in McArdle disease cell cultures using a variety of RTAs.
Mon Jan 13 00:00:00 UTC 2020
Live-cell imaging of single mRNA dynamics using split superfolder green fluorescent proteins with minimal background.
RNA (New York, N.Y.)
Park SY,Moon HC,Park HY
A-6455 was used in Western Blotting to demonstrate that the split sfGFP systems are useful tools for background-free imaging of mRNA with high spatiotemporal resolution.
Wed Jan 01 00:00:00 UTC 2020
RGS4 controls secretion of von Willebrand factor to the subendothelial matrix.
Journal of cell science
Patella F,Cutler DF
A-6455 was used in an ELISA assay to determine whether the constitutive release of subendothelial von Willebrand factoris actually regulated and, if so, what functional consequences this might have.
Fri Jul 24 00:00:00 UTC 2020
STRIPAK-PP2A regulates Hippo-Yorkie signaling to suppress retinal fate in the Drosophila eye disc peripodial epithelium.
Journal of cell science
Neal SJ,Zhou Q,Pignoni F
A-6455 was used in Immunohistochemistry to identify protein phosphatase 2A (PP2A), and specifically a STRIPAK-PP2A complex that includes the scaffolding and substrate-specificity components Cka, Strip and SLMAP, as a critical player in the retina-PE fate choice.
Tue May 26 00:00:00 UTC 2020
Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing.
Journal of cell science
Nair SV,Narendradev ND,Nambiar RP,Kumar R,Srinivasula SM
A-6455 was used in Immunocytochemistry-immunoflourescence to reveal a novel role of RNF167-a, as well as its natural variants RNF167-a-K97N and RNF167-b, as an upstream regulator of lysosomal exocytosis and plasma membrane resealing.
Thu Jun 11 00:00:00 UTC 2020
Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization.
Neuroendocrinology
Kim D,Jang S,Kim J,Park I,Ku K,Choi M,Lee S,Heo WD,Son GH,Choe HK,Kim K
A-6455 was used in Immunohistochemistry to examine the endogenous rhythmicity of ARN kisspeptin neurons and its neural regulation using a neonatal organotypic slice culture model.
Fri Aug 27 00:00:00 UTC 2021
Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex.
Cerebral cortex (New York, N.Y. : 1991)
De Gregorio R,Chen X,Petit EI,Dobrenis K,Sze JY
A-6455 was used in Immunohistochemistry to indicate that a precise architecture at the cortical destination is not essential for specifying late-developing interneuron identities, their cortical deposition, and spatial organization, but dictates their number and dendritic structure ultimately integrated into the cortex.
Sat Mar 14 00:00:00 UTC 2020
Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath.
Genetics
Palu RAS,Dalton HM,Chow CY
A-6455 was used in Immunohistochemistry to find that the uncharacterized, membrane-bound metallopeptidase CG14516 in Drosophila melanogaster, plays a role in modifying ER stress-induced apoptosis.
Wed Apr 01 00:00:00 UTC 2020
Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
Journal of neuroendocrinology
Georgescu T,Ladyman SR,Brown RSE,Grattan DR
A-6455 was used in Immunohistochemistry-floating tissue to investigate how widespread these rapid actions of prolactin are in regions of the brain with large populations of prolactin-sensitive neurones, and whether physiological state alters these responses.
Sun Nov 01 00:00:00 UTC 2020
Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation.
FEBS letters
Toki N,Takahashi H,Zucchelli S,Gustincich S,Carninci P
A-6455 was used in Western Blotting to reveal the functional role of RNA modifications in SINEUPs and suggest several broad clinical applications of such an RNA regulatory system.
Tue Dec 01 00:00:00 UTC 2020
Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation.
Neuroscience
Deal AL,Bass CE,Grinevich VP,Delbono O,Bonin KD,Weiner JL,Budygin EA
A-6455 was used in Immunohistochemistry to provide the first evidence that tonic LC-NE activity plays a causal role in stress-associated increases in drinking.
Tue Sep 01 00:00:00 UTC 2020
Atoh1 is required in supporting cells for regeneration of vestibular hair cells in adult mice.
Hearing research
Hicks KL,Wisner SR,Cox BC,Stone JS
A-6455 was used in Immunocytochemistry-Immunofluorescence to demonstrate that Atoh1 is necessary in adult mouse supporting cells for regeneration of type II vestibular hair cells and that deletion of Atoh1 from supporting cells prior to damage does not appear to induce supporting cells to die or to proliferate.
Wed Jan 01 00:00:00 UTC 2020
Zika virus NS5 localizes at centrosomes during cell division.
Virology
Kesari AS,Heintz VJ,Poudyal S,Miller AS,Kuhn RJ,LaCount DJ
A-6455 was used in Immunocytochemistry to show that ZIKV NS5 also relocalizes from the nucleus to centrosomes during mitosis.
Sat Feb 01 00:00:00 UTC 2020
TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells.
Biology of the cell
Manceau H,Lefevre SD,Mirmiran A,Hattab C,Sugier HR,Schmitt C,Peoc'h K,Puy H,Ostuni MA,Gouya L,Lacapere JJ
A-6455 was used in Western Blotting to show that ALA-induced PPIX accumulation in erythroid cells involves TSPO2 as a selective translocator through the plasma membrane.
Wed Apr 01 00:00:00 UTC 2020
Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse.
The Journal of comparative neurology
Negishi K,Payant MA,Schumacker KS,Wittmann G,Butler RM,Lechan RM,Steinbusch HWM,Khan AM,Chee MJ
A-6455 was used in Immunohistochemistry to indicate the existence of a novel mouse hypothalamic population that may signal through the release of GABA and/or dopamine.
Wed Jul 15 00:00:00 UTC 2020
A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.
Genesis (New York, N.Y. : 2000)
van de Moosdijk AAA,van de Grift YBC,de Man SMA,Zeeman AL,van Amerongen R
A-6455 was used in Western Blotting to report the generation and characterization of a new knock-in mouse strain that doubles as a fluorescent reporter and lineage tracing driver for WNT/CTNNB1 responsive cells.
Tue Sep 01 00:00:00 UTC 2020
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.
Science advances
Yu L,Zhang X,Yang Y,Li D,Tang K,Zhao Z,He W,Wang C,Sahoo N,Converso-Baran K,Davis CS,Brooks SV,Bigot A,Calvo R,Martinez NJ,Southall N,Hu X,Marugan J,Ferrer M,Xu H
A-6455 was used in Western Blot to show that transgenic overexpression or pharmacological activation of ML1 in vivo facilitates sarcolemma repair and alleviates the dystrophic phenotypes in both skeletal and cardiac muscles of mdx mice.
Sat Feb 01 00:00:00 UTC 2020
Grass-Specific EPAD1 Is Essential for Pollen Exine Patterning in Rice.
The Plant cell
Li H,Kim YJ,Yang L,Liu Z,Zhang J,Shi H,Huang G,Persson S,Zhang D,Liang W
A-6455 was used in Immunohistochemistry to demonstrate that EPAD1 is a meiocyte-derived determinant that controls primexine patterning in rice, and its orthologs may play a conserved role in the formation of grass-specific exine pattern elements.
Tue Dec 01 00:00:00 UTC 2020
Irradiation dependent inflammatory response may enhance satellite cell engraftment.
Scientific reports
Doreste B,Torelli S,Morgan J
A-6455 was used in Immunohistochemistry to hypothesise that, similar to other systems, cells damaged by radiation might be effecting this donor cell proliferation.
Mon Jul 06 00:00:00 UTC 2020
Superresolution Microscopy of Drosophila Indirect Flight Muscle Sarcomeres.
Bio-protocol
Szikora S,Novák T,Gajdos T,Erdélyi M,Mihály J
A-6455 was used in Immunohistochemistry to determine the position of dozens of H-zone and Z-disk proteins with a quasi-molecular, ~5-10 nm localization precision.
Sat Jun 20 00:00:00 UTC 2020
Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6).
The Journal of biological chemistry
Verma M,Zhu J,Wang KZQ,Chu CT
A-6455 was used in Western Blot to find that chronic MPP+ treatment of differentiated SH-SY5Y neuronal cells significantly decreases PINK1 expression prior to reductions in other mitochondrial components.
Fri Jun 05 00:00:00 UTC 2020
Framework with cytoskeletal actin filaments forming insect footpad hairs inspires biomimetic adhesive device design.
Communications biology
Kimura KI,Minami R,Yamahama Y,Hariyama T,Hosoda N
A-6455 was used in Immunocytochemistry-immunoflourescence to demonstrate that footpad hair in Drosophila is formed by the elongation of the hair cells and assembly of actin filaments.
Fri May 29 00:00:00 UTC 2020
Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia.
Brain sciences
Fowler PC,Byrne DJ,Blackstone C,O'Sullivan NC
A-6455 was used in Immunohistochemistry to report that knockdown of Arl6IP1 lowers Drp1 protein levels, resulting in reduced ER-mitochondrial contacts and impaired mitochondrial load at the distal ends of long motor neurons.
Thu Sep 17 00:00:00 UTC 2020
A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila.
eLife
Li TN,Chen YJ,Lu TY,Wang YT,Lin HC,Yao CK
A-6455 was used in Proximity Ligation Assay (PLA) to study the regulation of activity-dependent bulk endocytosis in drosophila.
Thu Dec 10 00:00:00 UTC 2020
Alternative splicing of the bicistronic gene molybdenum cofactor synthesis 1 (MOCS1) uncovers a novel mitochondrial protein maturation mechanism.
The Journal of biological chemistry
Mayr SJ,Röper J,Schwarz G
A-6455 was used in Western Blotting to report the cellular localization of alternatively spliced human MOCS1 proteins.
Fri Mar 06 00:00:00 UTC 2020
Visualization of naive and learned odor representations using in vivo calcium imaging and immunohistochemical bouton mapping of single Drosophila mushroom body neurons.
STAR protocols
Hancock CE,Geurten BRH,Fiala A
A-6455 was used in Immunohistochemistry to develop a method to quantify odor-induced calcium activity in Drosophila mushroom body neurons.
Fri Dec 18 00:00:00 UTC 2020
HIV-1 Gag release from yeast reveals ESCRT interaction with the Gag N-terminal protein region.
The Journal of biological chemistry
Meusser B,Purfuerst B,Luft FC
A-6455 was used in Immunoprecipitation to suggest that a transient matrix-ESCRT interaction is replaced when Gag binds to the plasma membrane. This step may activate ESCRT proteins and thereby coordinate ESCRT function with virion assembly.
Fri Dec 25 00:00:00 UTC 2020
ATG4 Mediated Psm ES4326/AvrRpt2-Induced Autophagy Dependent on Salicylic Acid in Arabidopsis Thaliana.
International journal of molecular sciences
Gong W,Li B,Zhang B,Chen W
A-6455 was used in Western Blotting to demonstrate that in npr1 (GFP-ATG8a), AvrRpt2 was more effective at inducing the production of autophagosome and autophagy flux than that in GFP-ATG8a.
Tue Jul 21 00:00:00 UTC 2020
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
PloS one
Ormsby AR,Cox D,Daly J,Priest D,Hinde E,Hatters DM
A-6455 was used in Immunocytochemistry-immunoflourescence to examine the mechanisms of inclusion assembly in a human epithelial kidney (AD293) cell culture model.
Tue Sep 08 00:00:00 UTC 2020
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
PloS one
Ormsby AR,Cox D,Daly J,Priest D,Hinde E,Hatters DM
A-6455 was used in Immunocytochemistry-immunoflourescence to examine the mechanisms of inclusion assembly in a human epithelial kidney (AD293) cell culture model.
Tue Sep 08 00:00:00 UTC 2020
A single-population GWAS identified AtMATE expression level polymorphism caused by promoter variants is associated with variation in aluminum tolerance in a local Arabidopsis population.
Plant direct
Nakano Y,Kusunoki K,Maruyama H,Enomoto T,Tokizawa M,Iuchi S,Kobayashi M,Kochian LV,Koyama H,Kobayashi Y
A-6455 was used in Chromatin immunoprecipitation to dissect the natural variation in AtMATE expression level in response to Al at the root using diverse natural accessions of Arabidopsis.
Sat Aug 01 00:00:00 UTC 2020
Exclusive vital labeling of myonuclei for studying myonuclear arrangement in mouse skeletal muscle tissue.
Skeletal muscle
Hastings RL,Massopust RT,Haddix SG,Lee YI,Thompson WJ
A-6455 was used in Immunohistochemistry to create a transgenic method to produce a selective and persistent myonuclear label in whole muscles of living mice.
Thu May 07 00:00:00 UTC 2020
Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.
The Journal of biological chemistry
Yamazoe T,Nagai T,Umeda S,Sugaya Y,Mizuno K
A-6455 was used in Western Blot, Immunoprecipitation to show cilium elongation, but not ciliogenesis, requires centrosomal protein 104.
Fri Oct 23 00:00:00 UTC 2020
Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.
The Journal of biological chemistry
Yamazoe T,Nagai T,Umeda S,Sugaya Y,Mizuno K
A-6455 was used in Western Blot, Immunoprecipitation to show cilium elongation, but not ciliogenesis, requires centrosomal protein 104.
Fri Oct 23 00:00:00 UTC 2020
Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes.
Molecular autism
Janickova L,Rechberger KF,Wey L,Schwaller B
A-6455 was used in Immunohistochemistry to suggest that parvalbumin is involved in most proposed mechanisms implicated in autism spectrum disorder etiology, such as changes in mitochondria structure/function and dendritic length/branching.
Tue Jun 09 00:00:00 UTC 2020
Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
PLoS genetics
Garrido D,Bourouh M,Bonneil É,Thibault P,Swan A,Archambault V
A-6455 was used in Immunocytochemistry to suggest that CycB3-Cdk1 directly activates the APC/C to promote anaphase in both meiosis and mitosis.
Sun Nov 01 00:00:00 UTC 2020
Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice.
Cell reports
Shih YT,Huang TN,Hu HT,Yen TL,Hsueh YP
A-6455 was used in Immunohistochemistry-immunofluorescence to suggest that leucine can effectively enter the brain and increase protein synthesis and dendritic spine density of Nf1+/- neurons.
Tue Jun 30 00:00:00 UTC 2020
Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders.
eLife
Melamed D,Kalderon D
A-6455 was used in Immunohistochemistry-fresh tissue to investigate how this is achieved for Drosophila Follicle Stem Cells (FSCs) by spatially-restricted niche signals.
Mon Nov 02 00:00:00 UTC 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
A-6455 was used in Immunohistochemistry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 UTC 2020
Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
The Journal of biological chemistry
Irie K,Nagai T,Mizuno K
A-6455 was used in Immunocytochemistry-immunoflourescence to construct Furry(FRY)-knockout cell lines to examine the role of FRY in yes-associated protein(YAP)'s cytoplasmic localization.
Fri Mar 06 00:00:00 UTC 2020
Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.
Nature communications
Kaur S,De Luca R,Khanday MA,Bandaru SS,Thomas RC,Broadhurst RY,Venner A,Todd WD,Fuller PM,Arrigoni E,Saper CB
A-6455 was used in Immunohistochemistry-immunofluorescence to indicate that the serotonergic input from the dorsal raphe to the parabrachial nucleus is critical for modulating the sensitivity of the PBelCGRP neurons that cause arousal to rising levels of blood CO2 during hypercapnia.
Tue Jun 02 00:00:00 UTC 2020
A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions.
PLoS genetics
Coste de Bagneaux P,von Elsner L,Bierhals T,Campiglio M,Johannsen J,Obermair GJ,Hempel M,Flucher BE,Kutsche K
A-6455 was used in Immunocytochemistry to investigate the functional implications of a CACNB4 missense variant in siblings with severe neurological disorder.
Sun Mar 01 00:00:00 UTC 2020
Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity.
Scientific reports
Girard V,Goubard V,Querenet M,Seugnet L,Pays L,Nataf S,Dufourd E,Cluet D,Mollereau B,Davoust N
A-6455 was used in Immunohistochemistry to investigate the functions of rhe RNA-binding protein SPEN/SHARP during Parkinson's disease.
Wed Nov 18 00:00:00 UTC 2020
The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates.
Nature communications
Park S,Aintablian A,Coupe B,Bouret SG
A-6455 was used in Immunohistochemistry-immunofluorescence to highlight the importance of early life endoplasmic reticulum (ER) stress-autophagy pathway in influencing hypothalamic circuits and metabolic regulation.
Mon Apr 20 00:00:00 UTC 2020
PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate.
eLife
Menuet C,Connelly AA,Bassi JK,Melo MR,Le S,Kamar J,Kumar NN,McDougall SJ,McMullan S,Allen AM
A-6455 was used in Immunohistochemistry-immunofluorescence to explore how PreBötzinger complex neurons modulate cardiovascular activity.
Mon Jun 15 00:00:00 UTC 2020
Ehrlichia chaffeensis EplA Interaction With Host Cell Protein Disulfide Isomerase Promotes Infection.
Frontiers in cellular and infection microbiology
Green RS,Izac JR,Naimi WA,O'Bier N,Breitschwerdt EB,Marconi RT,Carlyon JA
A-6455 was used in Western Blot to understand the Ehrlichial invasion of host cells.
Mon May 17 00:00:00 UTC 2021
Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons.
eLife
Sharma A,Hasan G
A-6455 was used in Immunohistochemistry to investigate the mechanism that IP3Rs modulate neuronal function for specific behaviours remain speculative, in vertebrates and invertebrates.
Fri Nov 06 00:00:00 UTC 2020
Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain.
Scientific reports
Furube E,Ishii H,Nambu Y,Kurganov E,Nagaoka S,Morita M,Miyata S
A-6455 was used in Immunohistochemistry to show the production of new neuronal lineage cells upon medulla oblongata brain damage is stimulated by neural stem cell in the adult mouse brain.
Tue Feb 18 00:00:00 UTC 2020
Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse.
Cell reports
Kim JY,Cho B,Moon C
A-6455 was used in Immunohistochemistry-immunofluorescence to determine the role of Abelson tyrosine-protein kinase 1 (Abl1) in the temporal development of early-born OB interneurons.
Tue Jan 07 00:00:00 UTC 2020
Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.
Scientific reports
Sutton AK,Gonzalez IE,Sadagurski M,Rajala M,Lu C,Allison MB,Adams JM,Myers MG,White MF,Olson DP
A-6455 was used in Immunohistochemistry to reveal a requisite role for IRS4PVH neurons in PVH-mediated energy balance which raises the possibility of developing novel approaches targeting IRS4PVH neurons for anti-obesity therapies.
Thu Mar 26 00:00:00 UTC 2020
Hippocampal hub neurons maintain distinct connectivity throughout their lifetime.
Nature communications
Bocchio M,Gouny C,Angulo-Garcia D,Toulat T,Tressard T,Quiroli E,Baude A,Cossart R
A-6455 was used in Immunohistochemistry-immunofluorescence to demonstrate that ebGABAs are highly involved in hippocampal network dynamics in development and adulthood.
Fri Sep 11 00:00:00 UTC 2020
Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
Nature communications
Vasudevan D,Neuman SD,Yang A,Lough L,Brown B,Bashirullah A,Cardozo T,Ryoo HD
A-6455 was used in Western Blot, Immunocytochemistry to indicate that eIF2D and DENR are critical mediators of ATF4 translational induction and stress responses in vivo.
Wed Sep 16 00:00:00 UTC 2020
Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
Nature communications
Vasudevan D,Neuman SD,Yang A,Lough L,Brown B,Bashirullah A,Cardozo T,Ryoo HD
A-6455 was used in Western Blot, Immunocytochemistry to indicate that eIF2D and DENR are critical mediators of ATF4 translational induction and stress responses in vivo.
Wed Sep 16 00:00:00 UTC 2020
A receptor-like protein mediates plant immune responses to herbivore-associated molecular patterns.
Proceedings of the National Academy of Sciences of the United States of America
Steinbrenner AD,Muñoz-Amatriaín M,Chaparro AF,Aguilar-Venegas JM,Lo S,Okuda S,Glauser G,Dongiovanni J,Shi D,Hall M,Crubaugh D,Holton N,Zipfel C,Abagyan R,Turlings TCJ,Close TJ,Huffaker A,Schmelz EA
A-6455 was used in Western Blot to support the role of plant immune receptors in the perception of chewing herbivores and defense.
Tue Dec 08 00:00:00 UTC 2020
Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
JCI insight
Liu Y,Lear TB,Verma M,Wang KZ,Otero PA,McKelvey AC,Dunn SR,Steer E,Bateman NW,Wu C,Jiang Y,Weathington NM,Rojas M,Chu CT,Chen BB,Mallampalli RK
A-6455 was used in Immunohistochemistry-immunofluorescence to show that a ubiquitin E3 ligase receptor component, FBXO7, targets (PTEN-induced kinase 1)PINK1 for its cellular disposal and induces mitochondrial injury and inflammation in experimental pneumonia.
Thu Jun 04 00:00:00 UTC 2020
teiresias, a Fruitless target gene encoding an immunoglobulin-superfamily transmembrane protein, is required for neuronal feminization in Drosophila.
Communications biology
Sato K,Ito H,Yamamoto D
A-6455 was used in Immunohistochemistry to identify transcriptional targets of FruitlessBM (FruBM).
Wed Oct 21 00:00:00 UTC 2020
Monitoring Viral Entry in Real-Time Using a Luciferase Recombinant Vesicular Stomatitis Virus Producing SARS-CoV-2, EBOV, LASV, CHIKV, and VSV Glycoproteins.
Viruses
Lay Mendoza MF,Acciani MD,Levit CN,Santa Maria C,Brindley MA
A-6455 was used in Western Blotting to examine the entry efficiencies of diverse viral glycoproteins.
Thu Dec 17 00:00:00 UTC 2020
Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development.
Scientific reports
Weiss AR,Liguore WA,Domire JS,Button D,McBride JL
A-6455 was used in Immunohistochemistry to compare the biodistribution of AAV2.retro with its parent serotype, AAV2, in adult macaques following delivery into the caudate and putamen, brain regions which comprise the striatum.
Fri Apr 24 00:00:00 UTC 2020
Encoding and control of orientation to airflow by a set of Drosophila fan-shaped body neurons.
eLife
Currier TA,Matheson AM,Nagel KI
A-6455 was used in Immunohistochemistry to identify a group of CX neurons that robustly encode airflow direction and are required for proper orientation to this stimulus.
Wed Dec 30 00:00:00 UTC 2020
Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo.
Molecular brain
Kunisawa K,Hatanaka N,Shimizu T,Kobayashi K,Osanai Y,Mouri A,Shi Q,Bhat MA,Nambu A,Ikenaka K
A-6455 was used in Immunohistochemistry to examine whether neurofascin155 influences the electrophysiological properties of the mouse motor system.
Mon Nov 23 00:00:00 UTC 2020
Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability.
The Journal of biological chemistry
Chen PJ,Zelada D,Belhasan DC,Akaaboune M
A-6455 was used in Western Blotting to indicate that the stability of αkap and α-dbn complex plays an important role in the maintenance of high-level expression of AChRs.
Fri Jul 31 00:00:00 UTC 2020
Wrapping glia regulates neuronal signaling speed and precision in the peripheral nervous system of Drosophila.
Nature communications
Kottmeier R,Bittern J,Schoofs A,Scheiwe F,Matzat T,Pankratz M,Klämbt C
A-6455 was used in Immunohistochemistry to investigate how glia regulate axonal properties in Dropshilia larvae.
Tue Sep 08 00:00:00 UTC 2020
Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders.
Frontiers in cellular neuroscience
Janickova L,Schwaller B
A-6455 was used in Immunohistochemistry to indicate that the ASD-like phenotype in PV−/− mice emerges before the onset of an increase in oxidative stress hinting toward absence/reduction of PV as the main contributor to the behavioral ASD-like phenotype.
Sun Nov 12 00:00:00 UTC 2023
Homologous Proteins of the Manganese Transporter PAM71 Are Localized in the Golgi Apparatus and Endoplasmic Reticulum.
Plants (Basel, Switzerland)
Hoecker N,Honke A,Frey K,Leister D,Schneider A
A-6455 was used in Western Blot to understand the function and location of photosynthesis-affected mutant 71 like 3 (PML3), PML4 and PML5 in Arabidopsis thaliana.
Thu Feb 13 00:00:00 UTC 2020
Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.
Neural development
Patoori S,Jean-Charles N,Gopal A,Sulaiman S,Gopal S,Wang B,Souferi B,Emerson MM
A-6455 was used in Immunohistochemistry to identify spatiotemporally specific regulatory elements near the Onecut1 locus.
Thu Mar 19 00:00:00 UTC 2020
Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility.
Nature communications
Washburn HR,Xia NL,Zhou W,Mao YT,Dalva MB
A-6455 was used in Western Blot to demonstrate that the positive surface charge of the hinge region of the N-terminal domain in the GluN1 subunit of the NMDAR is required to maintain NMDARs at dendritic spine synapses and mediates the direct extracellular interaction with a negatively charged phospho-tyrosine on the receptor tyrosine kinase EphB2.
Wed Jan 29 00:00:00 UTC 2020
KRAS4A directly regulates hexokinase 1.
Nature
Amendola CR,Mahaffey JP,Parker SJ,Ahearn IM,Chen WC,Zhou M,Court H,Shi J,Mendoza SL,Morten MJ,Rothenberg E,Gottlieb E,Wadghiri YZ,Possemato R,Hubbard SR,Balmain A,Kimmelman AC,Philips MR
A-6455 was used in Western Blotting to show that the expression of KRAS4A in cancer may drive unique metabolic vulnerabilities that can be exploited therapeutically.
Sun Dec 01 00:00:00 UTC 2019
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Immunity
Zhao Y,Lee CK,Lin CH,Gassen RB,Xu X,Huang Z,Xiao C,Bonorino C,Lu LF,Bui JD,Hui E
A-6455 was used in Western Blot to conclude that PD-L1 exerts an immunostimulatory effect by repressing the CTLA-4 axis; this has implications to the synergy of anti-PD-L1 and anti-CTLA-4 combination therapy.
Tue Dec 17 00:00:00 UTC 2019
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Molecular cell
Chino H,Hatta T,Natsume T,Mizushima N
A-6455 was used in Western Blot to identify selective autophagy substrates, receptors, or adaptors, by performing differential interactome analysis using a wild-type (WT) LC3B and a LIR recognition-defective LC3B mutant.
Thu Jun 06 00:00:00 UTC 2019
Encoding of Wind Direction by Central Neurons in Drosophila.
Neuron
Suver MP,Matheson AMM,Sarkar S,Damiata M,Schoppik D,Nagel KI
A-6455 was used in Immunohistochemistry to establish how a feature of the sensory environment-wind direction-is decoded by neurons that compare information across two sensors.
Wed May 22 00:00:00 UTC 2019
p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.
Neuron
Bonanomi D,Valenza F,Chivatakarn O,Sternfeld MJ,Driscoll SP,Aslanian A,Lettieri K,Gullo M,Badaloni A,Lewcock JW,Hunter T,Pfaff SL
A-6455 was used in Immunocytochemistry-Immunofluorescence to study the role of Rho GTPase antagonist p190RhoGAP as a critical regulator of motor axon guidance.
Wed May 08 00:00:00 UTC 2019
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Neuron
Heck J,Parutto P,Ciuraszkiewicz A,Bikbaev A,Freund R,Mitlöhner J,Andres-Alonso M,Fejtova A,Holcman D,Heine M
A-6455 was used in Immunocytochemistry-immunoflourescence to propose that exon 47-related alternative splicing of CaV2.1 channels controls synapse-specific release properties at the level of channel mobility-dependent coupling between VGCCs and SVs.
Wed Jul 03 00:00:00 UTC 2019
SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior.
Molecular psychiatry
Soiza-Reilly M,Meye FJ,Olusakin J,Telley L,Petit E,Chen X,Mameli M,Jabaudon D,Sze JY,Gaspar P
A-6455 was used in Immunohistochemistry to demonstrate that developmental expression of SERT in a subset of prefrontal cortex neurons controls synaptic maturation of PFC-to-DRN circuits.
Wed May 01 00:00:00 UTC 2019
Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
Developmental cell
Egge N,Arneaud SLB,Wales P,Mihelakis M,McClendon J,Fonseca RS,Savelle C,Gonzalez I,Ghorashi A,Yadavalli S,Lehman WJ,Mirzaei H,Douglas PM
A-6455 was used in Western Blotting to show that an uncharacterized phosphorylation of a low-abundant actin variant, ACT-5, compromises integrity of the C. elegans intestinal barrier and accelerates pathogenesis.
Mon Dec 02 00:00:00 UTC 2019
Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.
Autophagy
Robin M,Issa AR,Santos CC,Napoletano F,Petitgas C,Chatelain G,Ruby M,Walter L,Birman S,Domingos PM,Calvi BR,Mollereau B
A-6455 was used in Immunohistochemistry-immunofluorescence to demonstrate that the differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress.
Wed May 01 00:00:00 UTC 2019
Transcriptional Repression of the APC/C Activator Genes CCS52A1/A2 by the Mediator Complex Subunit MED16 Controls Endoreduplication and Cell Growth in Arabidopsis.
The Plant cell
Liu Z,Chen G,Gao F,Xu R,Li N,Zhang Y,Li Y
A-6455 was used in Chromatin immunoprecipitation to study MED16 interactions with the transcriptional repressor DEL1 to repress the expression of CCS52A2. Investigative genetic analysis suggested that MED16 is partially dependent on CCS52A1/A2 to control endoreduplication and cell growth.
Thu Aug 01 00:00:00 UTC 2019
The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila.
Current biology : CB
Byun PK,Zhang C,Yao B,Wardwell-Ozgo J,Terry D,Jin P,Moberg K
A-6455 was used in Immunohistochemistry to study the role of Drosophila Taiman protein involvement in signalling cascades.
Mon Sep 09 00:00:00 UTC 2019
Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation.
Current biology : CB
Ma Y,Miracca G,Yu X,Harding EC,Miao A,Yustos R,Vyssotski AL,Franks NP,Wisden W
A-6455 was used in Immunohistochemistry to show that mice with lesioned PO galanin neurons have reduced sleep homeostasis: in the recovery sleep following sleep deprivation there is a diminished increase in delta power, and the mice catch up little on lost sleep.
Mon Oct 07 00:00:00 UTC 2019
The Lateral Root Cap Acts as an Auxin Sink that Controls Meristem Size.
Current biology : CB
Di Mambro R,Svolacchia N,Dello Ioio R,Pierdonati E,Salvi E,Pedrazzini E,Vitale A,Perilli S,Sozzani R,Benfey PN,Busch W,Costantino P,Sabatini S
A-6455 was used in Western Blotting to indicate that the lateral root cap (LRC) serves as an auxin sink that, under the control of cytokinin, regulates meristem size and root growth.
Mon Apr 01 00:00:00 UTC 2019
Lateral root initiation requires the sequential induction of transcription factors LBD16 and PUCHI in Arabidopsis thaliana.
The New phytologist
Goh T,Toyokura K,Yamaguchi N,Okamoto Y,Uehara T,Kaneko S,Takebayashi Y,Kasahara H,Ikeyama Y,Okushima Y,Nakajima K,Mimura T,Tasaka M,Fukaki H
A-6455 was used in Chromatin immunoprecipitation to identify key genes for lateral root formation that are activated by LBD16 in an auxin-dependent manner.
Tue Oct 01 00:00:00 UTC 2019
Selective suppression and recall of long-term memories in Drosophila.
PLoS biology
Siegenthaler D,Escribano B,Bräuler V,Pielage J
A-6455 was used in Immunohistochemistry to develop a cAMP response element-activity-dependent memory engram label tool that genetically tags Kenyon cells responding to the conditioned stimulus.
Thu Aug 01 00:00:00 UTC 2019
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Journal of molecular cell biology
Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X
A-6455 was used in Immunocytochemistry-immunoflourescence to look into whether, unlike its Chlamydomonas counterpart, vertebrate Dynein-f is essential for ciliary beat. We confirmed that Wdr78 is the vertebrate orthologue of IC138. Wdr78 associated with Dynein-f subunits such as Dnah2 (a HC) and Wdr63 (IC140 orthologue).
Wed May 01 00:00:00 UTC 2019
PTEN reduces endosomal PtdIns(4,5)P2 in a phosphatase-independent manner via a PLC pathway.
The Journal of cell biology
Mondin VE,Ben El Kadhi K,Cauvin C,Jackson-Crawford A,Bélanger E,Decelle B,Salomon R,Lowe M,Echard A,Carréno S
A-6455 was used in Immunocytochemistry-immunoflourescence to study the function of the tumor supressor, PTEN, in Lowe syndrome.
Mon Jul 01 00:00:00 UTC 2019
Pineal progenitors originate from a non-neural territory limited by FGF signalling.
Development (Cambridge, England)
Staudt N,Giger FA,Fielding T,Hutt JA,Foucher I,Snowden V,Hellich A,Kiecker C,Houart C
A-6455 was used in Immunohistochemistry to show that pineal progenitors originate, at least in part, from the non-neural ectoderm.
Thu Nov 21 00:00:00 UTC 2019
Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Venner A,Mochizuki T,De Luca R,Anaclet C,Scammell TE,Saper CB,Arrigoni E,Fuller PM
A-6455 was used in Immunohistochemistry-immunofluorescence to investigate the effects of selective chronic disruption of GABA synthesis (via genetic deletion of the GABA synthesis enzyme, glutamic acid decarboxylase 67) or GABAergic transmission (via genetic deletion of the vesicular GABA transporter (VGAT)) in the tuberomammillary nucleus of the hypothalamus neurons on sleep-wake in male mice.
Wed Nov 06 00:00:00 UTC 2019
Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Matsumoto M,Sawada M,García-González D,Herranz-Pérez V,Ogino T,Bang Nguyen H,Quynh Thai T,Narita K,Kumamoto N,Ugawa S,Saito Y,Takeda S,Kaneko N,Khodosevich K,Monyer H,García-Verdugo JM,Ohno N,Sawamoto K
A-6455 was used in Immunohistochemistry to demonstrate highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts.
Wed Dec 11 00:00:00 UTC 2019
Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface.
Traffic (Copenhagen, Denmark)
Röhl J,West ZE,Rudolph M,Zaharia A,Van Lonkhuyzen D,Hickey DK,Semmler ABT,Murray RZ
A-6455 was used in Immunoprecipitation to show that unlike the constitutive membrane-type-1 matrix metalloproteinase surface recycling seen in cancer cells, unactivated macrophages express low levels of membrane-type-1 matrix metalloproteinase.
Sun Sep 01 00:00:00 UTC 2019
Monensin Sensitive 1 Regulates Dendritic Arborization in Drosophila by Modulating Endocytic Flux.
Frontiers in cell and developmental biology
Harish RK,Tendulkar S,Deivasigamani S,Ratnaparkhi A,Ratnaparkhi GS
A-6455 was used in Immunohistochemistry to conduct genetic epistasis experiments, by modulating the activity of Rab5, Rab7, and Rab11 in da neurons, in Mon1 mutants, and demonstrate that the ability of Mon1 to regulate arborization is possibly due to its effect on the recycling pathway.
Thu Oct 01 00:00:00 UTC 2020
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
European journal of cell biology
Solga R,Behrens J,Ziemann A,Riou A,Berwanger C,Becker L,Garrett L,de Angelis MH,Fischer L,Coras R,Barkovits K,Marcus K,Mahabir E,Eichinger L,Schröder R,Noegel AA,Clemen CS
A-6455 was used in Immunohistochemistry to demonstrate that CRN2 increased the secretion of TIMP4 as well as the catalytic activity of MMP14. Implying that CRN2 represents a pro-invasive effector within the tumour cell microenvironment of glioblastoma multiforme.
Sun Dec 01 00:00:00 UTC 2019
The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.
Journal of leukocyte biology
Ramadass M,Johnson JL,Marki A,Zhang J,Wolf D,Kiosses WB,Pestonjamasp K,Ley K,Catz SD
A-6455 was used in Western Blotting to show that defective Rac1-GTP recycling from the uropod affects directionality, highlighting JFC1-mediated Rac1 trafficking as a potential target to regulate chemotaxis in inflammation and immunity.
Sat Jun 01 00:00:00 UTC 2019
Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Phillipps HR,Rand CJ,Brown RSE,Kokay IC,Stanton JA,Grattan DR
A-6455 was used in Immunohistochemistry to show that prolactin receptors in the choroid plexus are not required for prolactin transport into the brain in knockout mice.
Wed May 01 00:00:00 UTC 2019
Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics.
Frontiers in psychiatry
Gréa H,Bouchet D,Rogemond V,Hamdani N,Le Guen E,Tamouza R,Darrau E,Passerieux C,Honnorat J,Leboyer M,Groc L
A-6455 was used in Immunohistochemistry to indicate that N-methyl-D-aspartate receptors (NMDAR-Ab) from patients with psychotic symptoms alter the trafficking of D1R, likely through the surface crosstalk between NMDAR and D1R.
Thu Oct 01 00:00:00 UTC 2020
Imaging and Manipulating Pituitary Function in the Awake Mouse.
Endocrinology
Hoa O,Lafont C,Fontanaud P,Guillou A,Kemkem Y,Kineman RD,Luque RM,Fiordelisio Coll T,Le Tissier P,Mollard P
A-6455 was used in Immunohistochemistry-immunofluorescence to establish a suite of adaptable methodologies to interrogate in vivo the relationship of hypothalamic regulation with the secretory output of the pituitary gland, which has complex functional networks of multiple cell types intermingled with the vasculature.
Tue Oct 01 00:00:00 UTC 2019
Organelle Studies and Proteome Analyses of Mitochondria and Plastids Fractions from the Diatom Thalassiosira pseudonana.
Plant & cell physiology
Schober AF,Rï O Bï Rtulos C,Bischoff A,Lepetit B,Gruber A,Kroth PG
A-6455 was used in Western Blotting to establish the first isolation protocol for mitochondria from the model diatom Thalassiosira pseudonana.
Thu Aug 01 00:00:00 UTC 2019
Loss-of-Function Mutations in Human Regulator of G Protein Signaling RGS2 Differentially Regulate Pharmacological Reactivity of Resistance Vasculature.
Molecular pharmacology
Phan HTN,Jackson WF,Shaw VS,Watts SW,Neubig RR
A-6455 was used in Immunocytochemistry-immunoflourescence to investigate whether those regulator of G protein signaling 2 (RGS2)loss-of-function (LOF) mutations disrupt the ability of RGS2 to regulate vascular reactivity.
Sun Dec 01 00:00:00 UTC 2019
Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.
Genes, brain, and behavior
Adhikari P,Orozco D,Randhawa H,Wolf FW
A-6455 was used in Immunohistochemistry-wholemount to study the role of Hr38 in ethanol behavioural plasticity.
Fri Mar 01 00:00:00 UTC 2019
Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation.
Molecular biology of the cell
El-Amine N,Carim SC,Wernike D,Hickson GRX
A-6455 was used in Western Blot to show how midbody ring biogenesis depends on the coordinated actions of Sticky, Anillin, and Rho.
Thu Aug 01 00:00:00 UTC 2019
FGFR1 regulates trophectoderm development and facilitates blastocyst implantation.
Developmental biology
Kurowski A,Molotkov A,Soriano P
A-6455 was used in Immunocytochemistry-Immunofluorescence to investigate the basis for the Fgfr1-/- and Fgfr1-/-Fgfr2-/- peri-implantation lethality.
Fri Feb 01 00:00:00 UTC 2019
Particle-Mediated Gene Transfection and Organotypic Culture of Postmortem Human Retina.
Translational vision science & technology
Masri RA,Lee SCS,Madigan MC,Grünert U
A-6455 was used in Immunohistochemistry-immunofluorescence to apply particle-mediated gene transfer method to transfect ganglion cells in postmortem human retina.
Fri Mar 01 00:00:00 UTC 2019
Sub-topographic maps for regionally enhanced analysis of visual space in the mouse retina.
The Journal of comparative neurology
El-Danaf RN,Huberman AD
A-6455 was used in Immunohistochemistry to evaluate the dendritic arbor extent and soma size of each cell according to its specific retinotopic position.
Tue Jan 01 00:00:00 UTC 2019
The M6 cell: A small-field bistratified photosensitive retinal ganglion cell.
The Journal of comparative neurology
Quattrochi LE,Stabio ME,Kim I,Ilardi MC,Michelle Fogerson P,Leyrer ML,Berson DM
A-6455 was used in Immunohistochemistry-immunofluorescence to show that M6 cells are by far the most abundant ganglion cell type labeled in adult pigmented Cdh3-GFP BAC transgenic mice.
Tue Jan 01 00:00:00 UTC 2019
Vangl2 coordinates cell rearrangements during gut elongation.
Developmental dynamics : an official publication of the American Association of Anatomists
Dush MK,Nascone-Yoder NM
A-6455 was used in Immunohistochemistry to identify how asymmetrical enrichment of Vangl2 in individual gut endoderm cells coordinates digestive epithelial morphogenesis and lumen formation with gut tube elongation.
Mon Jul 01 00:00:00 UTC 2019
Lineage-specific determination of ring neuron circuitry in the central complex of Drosophila.
Biology open
Bridi JC,Ludlow ZN,Hirth F
A-6455 was used in Immunohistochemistry to identify two stem cells in the embryonic neuroectoderm as precursor cells of neuronal progeny that establish ellipsoid body (EB) circuits in the adult brain of Drosophila.
Mon Jul 22 00:00:00 UTC 2019
Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction.
Genes to cells : devoted to molecular & cellular mechanisms
Fujiwara S,Matsui TS,Ohashi K,Mizuno K,Deguchi S
A-6455 was used in Chromatin immunoprecipitation to investigate Solo and keratin 8/keratin 18 filament interactions and the localization and mechanotransduction-regulating function of Solo.
Wed May 01 00:00:00 UTC 2019
Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons.
Toxins
Joussain C,Le Coz O,Pichugin A,Marconi P,Lim F,Sicurella M,Salonia A,Montorsi F,Wandosell F,Foster K,Giuliano F,Epstein AL,Aranda Muñoz A
A-6455 was used in ELISA to assess the properties of a set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F in primary cultures of rat embryonic dorsal root ganglia (DRG) neurons, and in organotypic cultures of explanted DRG from adult rats..
Tue Feb 19 00:00:00 UTC 2019
Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
Scientific reports
Rajah A,Boudreau CG,Ilie A,Wee TL,Tang K,Borisov AZ,Orlowski J,Brown CM
A-6455 was used in Immunoprecipitation to show that phosphorylation on paxillin S273 leads to highly migratory cells with small dynamic adhesions.
Wed Aug 07 00:00:00 UTC 2019
Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
Scientific reports
Rajah A,Boudreau CG,Ilie A,Wee TL,Tang K,Borisov AZ,Orlowski J,Brown CM
A-6455 was used in Immunoprecipitation to show that phosphorylation on paxillin S273 leads to highly migratory cells with small dynamic adhesions.
Wed Aug 07 00:00:00 UTC 2019
Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation.
International journal of molecular sciences
Castells-Ballester J,Rinis N,Kotan I,Gal L,Bausewein D,Kats I,Zatorska E,Kramer G,Bukau B,Schuldiner M,Strahl S
A-6455 was used in Western Blot to find that Bfr1 affects O-mannosylation through changes in Pmt1 and Pmt2 protein abundance but has no effect on PMT1 and PMT2 transcript levels, mRNA localization to the ER membrane or protein stability.
Tue Dec 10 00:00:00 UTC 2019
Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.
eLife
Donovan LJ,Spencer WC,Kitt MM,Eastman BA,Lobur KJ,Jiao K,Silver J,Deneris ES
A-6455 was used in Immunohistochemistry to study the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development.
Mon Jul 29 00:00:00 UTC 2019
The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.
Cell reports
Xu C,Tang HW,Hung RJ,Hu Y,Ni X,Housden BE,Perrimon N
A-6455 was used in Immunohistochemistry to determine how Yorkie activity is inhibited following tissue repair.
Tue Jan 15 00:00:00 UTC 2019
A specific isoform of Pyd/ZO-1 mediates junctional remodeling and formation of slit diaphragms.
The Journal of cell biology
Carrasco-Rando M,Prieto-Sánchez S,Culi J,Tutor AS,Ruiz-Gómez M
A-6455 was used in Immunohistochemistry to show that a specific isoform of Polychaetoid/ZO-1, Pyd-P, is essential for Drosophila SDs, since, in pyd mutants devoid of Pyd-P, SDs do not form and the SD component Dumbfounded accumulates at ectopic septate-like junctions between abnormally aggregated nephrocytes.
Mon Jul 01 00:00:00 UTC 2019
A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization.
Scientific reports
Epp AL,Ebert SN,Sanchez-Arias JC,Wicki-Stordeur LE,Boyce AKJ,Swayne LA
A-6455 was used in Western Blotting to present discovery of a putative leucine-rich repeat motif in the proximal Panx1CT necessary for Panx1 cell surface expression in HEK293T cells.
Fri Jul 05 00:00:00 UTC 2019
Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina.
Scientific reports
Schick E,McCaffery SD,Keblish EE,Thakurdin C,Emerson MM
A-6455 was used in Immunohistochemistry to describe the development and validation of a recombinase-based lineage tracing system for the chicken embryo to further characterize the lineage of these cells.
Thu Jun 27 00:00:00 UTC 2019
Chromosome territory formation attenuates the translocation potential of cells.
eLife
Rosin LF,Crocker O,Isenhart RL,Nguyen SC,Xu Z,Joyce EF
A-6455 was used in Immunocytochemistry-immunoflourescence to suggest the genome can be protected from deleterious transolcations in the presence of DNA damage by proper chromosome territory formation.
Mon Nov 04 00:00:00 UTC 2019
Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
Cell reports
Levin E,Leibinger M,Gobrecht P,Hilla A,Andreadaki A,Fischer D
A-6455 was used in Immunocytochemistry-immunoflourescence to suggest that muscle LIM protein acts as an actin cross-linker, thereby facilitating filopodia formation and increasing growth cone motility for promoting nerve repair.
Tue Jan 22 00:00:00 UTC 2019
Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
Cell reports
Levin E,Leibinger M,Gobrecht P,Hilla A,Andreadaki A,Fischer D
A-6455 was used in Immunocytochemistry-immunoflourescence to suggest that muscle LIM protein acts as an actin cross-linker, thereby facilitating filopodia formation and increasing growth cone motility for promoting nerve repair.
Tue Jan 22 00:00:00 UTC 2019
Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis.
Nature communications
Shimokawa-Chiba N,Müller C,Fujiwara K,Beckert B,Ito K,Wilson DN,Chiba S
A-6455 was used in Western Blotting to show that the Gram-positive Bacillus subtilis has an evolutionarily distinct ribosome rescue factor named BrfA.
Wed Nov 27 00:00:00 UTC 2019
Detection of in vivo Protein Interactions in All Bacterial Components by Förster Resonance Energy Transfer with the Superfolder mTurquoise2 ox-mNeongreen FRET Pair.
Bio-protocol
Meiresonne NY,Consoli E,Mertens LMY,den Blaauwen T
A-6455 was used in Western Blot to develop a protocol to qualitatively and quantitatively detect protein-protein interactions in all compartments of Escherichia coli by Förster Resonance Energy Transfer (FRET) using the Superfolder mTurquoise2 ox-mNeonGreen FRET pair (sfTq2ox-mNG).
Thu Dec 05 00:00:00 UTC 2019
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.
Nature communications
Watanabe S,Amagai Y,Sannino S,Tempio T,Anelli T,Harayama M,Masui S,Sorrentino I,Yamada M,Sitia R,Inaba K
A-6455 was used in Western Blotting to study the role of zinc ions as a regulator of protein quality in the early secretory pathway.
Tue Feb 05 00:00:00 UTC 2019
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers.
Nature communications
Watanabe S,Hayashi K,Toh K,Kim HJ,Liu X,Chaya H,Fukushima S,Katsushima K,Kondo Y,Uchida S,Ogura S,Nomoto T,Takemoto H,Cabral H,Kinoh H,Tanaka HY,Kano MR,Matsumoto Y,Fukuhara H,Uchida S,Nangaku M,Osada K,Nishiyama N,Miyata K,Kataoka K
A-6455 was used in Western Blotting to report an alternative approach to cancer targeted oligonucleotide delivery using charge-matched block catiomers, capable of efficiently delivery oligonucleotides into pancreatic and brain tumour models and exerting significant antitumour activity.
Wed Apr 24 00:00:00 UTC 2019
Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G.
Molecular pharmacology
Saito M,Cui L,Hirano M,Li G,Yanagisawa T,Sato T,Sukegawa J
A-6455 was used in Immunocytochemistry to provide a novel regulatory mechanism that AC6 activity is suppressed by the direct binding of 4.1G to AC6-N, resulting in attenuation of PTHR-mediated Gs/AC6/cAMP signaling.
Tue Oct 01 00:00:00 UTC 2019
Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G.
Molecular pharmacology
Saito M,Cui L,Hirano M,Li G,Yanagisawa T,Sato T,Sukegawa J
A-6455 was used in Immunocytochemistry to provide a novel regulatory mechanism that AC6 activity is suppressed by the direct binding of 4.1G to AC6-N, resulting in attenuation of PTHR-mediated Gs/AC6/cAMP signaling.
Tue Oct 01 00:00:00 UTC 2019
Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G.
Molecular pharmacology
Saito M,Cui L,Hirano M,Li G,Yanagisawa T,Sato T,Sukegawa J
A-6455 was used in Immunocytochemistry to provide a novel regulatory mechanism that AC6 activity is suppressed by the direct binding of 4.1G to AC6-N, resulting in attenuation of PTHR-mediated Gs/AC6/cAMP signaling.
Tue Oct 01 00:00:00 UTC 2019
Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons.
Cell reports
Li S,Shi Y,Yao X,Wang X,Shen L,Rao Z,Yuan J,Liu Y,Zhou Z,Zhang Z,Liu F,Han S,Geng J,Yang H,Cheng L
A-6455 was used in Immunohistochemistry to show that seven transcription factors (TFs) (Ascl1, Phox2b, AP-2α, Gata3, Hand2, Nurr1, and Phox2a) are able to convert astrocytes and fibroblasts into induced NA (iNA) neurons.
Tue Jul 16 00:00:00 UTC 2019
Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.
Neuron
Clark BS,Stein-O'Brien GL,Shiau F,Cannon GH,Davis-Marcisak E,Sherman T,Santiago CP,Hoang TV,Rajaii F,James-Esposito RE,Gronostajski RM,Fertig EJ,Goff LA,Blackshaw S
A-6455 was used in Immunohistochemistry to profile ten developmental stages encompassing the full course of retinal neurogenesis using single-cell RNA sequencing.
Wed Jun 19 00:00:00 UTC 2019
MoGT2 Is Essential for Morphogenesis and Pathogenicity of Magnaporthe oryzae.
mSphere
Deng S,Sun W,Dong L,Cui G,Deng YZ
A-6455 was used in Western Blotting to report on type 2 glycosyltransferase function in M. oryzae infection-related morphogenesis and pathogenesis.
Wed Sep 04 00:00:00 UTC 2019
Sphingolipid-dependent Dscam sorting regulates axon segregation.
Nature communications
Goyal G,Zheng J,Adam E,Steffes G,Jain M,Klavins K,Hummel T
A-6455 was used in Western Blotting to show that sphingolipids are critical to organize early protein targeting to axonal and dendritic processes in Drosophila neurons.
Mon Feb 18 00:00:00 UTC 2019
Scribble and Discs Large mediate tricellular junction formation.
Development (Cambridge, England)
Sharifkhodaei Z,Gilbert MM,Auld VJ
A-6455 was used in Immunohistochemistry to propose a model in which Scrib and Dlg are key components of the TCJ, and form a complex with Bark and Gli.
Mon Sep 23 00:00:00 UTC 2019
Genetic Lineage Tracing of Biliary Epithelial Cells.
Methods in molecular biology (Clifton, N.J.)
Rubio-Tomás T,Aguilar-Bravo B,Sancho-Bru P
A-6455 was used in Immunohistochemistry to suggest possible readouts to assess BECs fate based on immunofluorescence analysis.
Tue Jun 11 00:00:00 UTC 2019
Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation.
Nature communications
Ali H,Mano M,Braga L,Naseem A,Marini B,Vu DM,Collesi C,Meroni G,Lusic M,Giacca M
A-6455 was used in Immunocytochemistry to report that the E3 RING ligase TRIM33 is a major determinant of HIV-1 IN stability.
Mon Feb 25 00:00:00 UTC 2019
Endothelial cell clonal expansion in the development of cerebral cavernous malformations.
Nature communications
Malinverno M,Maderna C,Abu Taha A,Corada M,Orsenigo F,Valentino M,Pisati F,Fusco C,Graziano P,Giannotta M,Yu QC,Zeng YA,Lampugnani MG,Magnusson PU,Dejana E
A-6455 was used in Immunohistochemistry-immunofluorescence to show that characteristics of Ccm3-null cells are reminiscent of the tumour-initiating cells that are responsible for tumour growth and support the concept that CCM has benign tumour characteristics.
Mon Jun 24 00:00:00 UTC 2019
The Recovery from Sulfur Starvation Is Independent from the mRNA Degradation Initiation Enzyme PARN in Arabidopsis.
Plants (Basel, Switzerland)
Armbruster L,Uslu VV,Wirtz M,Hell R
A-6455 was used in Western Blotting to detect PARN in cytoplasmic speckles and reconcile the diverging views in literature by identifying two PARN splice variants whose predicted localization is in agreement with those observations.
Fri Sep 27 00:00:00 UTC 2019
Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo.
Nature communications
Liu B,Satou Y
A-6455 was used in Immunohistochemistry-immunofluorescence to show that Foxg begins to be expressed in two separate rows of cells within the neural plate boundary region under the control of the MAPK pathway.
Tue Oct 29 00:00:00 UTC 2019
Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10.
Scientific reports
Yokoyama T,Yukuhiro M,Iwasaki Y,Tanaka C,Sankoda K,Fujiwara R,Shibuta A,Higashi T,Motoyama K,Arima H,Yoshida K,Sugimoto N,Morimoto H,Kosako H,Ohshima T,Fujita M
A-6455 was used in Western Blotting to identify targets of the antineoplastic antimitotic agent NP-10.
Thu Nov 14 00:00:00 UTC 2019
Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting.
Cells
Clarkson YL,Weatherall E,Waterfall M,McLaughlin M,Lu H,Skehel PA,Anderson RA,Telfer EE
A-6455 was used in Immunocytochemistry-immunoflourescence to determine whether localisation of the C-terminus of human DDX4 on the cell surface was possible. DAB staining and western blot analysis was carried out.
Wed Jun 12 00:00:00 UTC 2019
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
The Journal of biological chemistry
Zhang Q,Xiao K,Paredes JM,Mamonova T,Sneddon WB,Liu H,Wang D,Li S,McGarvey JC,Uehling D,Al-Awar R,Joseph B,Jean-Alphonse F,Orte A,Friedman PA
A-6455 was used in Western Blot to reveal how reversible phosphorylation modifies protein conformation and function and the biochemical mechanisms underlying PTH control of phosphate transport.
Fri Mar 22 00:00:00 UTC 2019
Non-Cell-Autonomous Function of the GPI-Anchored Protein Undicht during Septate Junction Assembly.
Cell reports
Petri J,Syed MH,Rey S,Klämbt C
A-6455 was used in Immunohistochemistry to identify a GPI-anchored protein called Undicht required for septate junction formation.
Tue Feb 05 00:00:00 UTC 2019
Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1.
Frontiers in immunology
Collmann FM,Pijnenburg R,Hamzei-Taj S,Minassian A,Folz-Donahue K,Kukat C,Aswendt M,Hoehn M
A-6455 was used in Immunohistochemistry-immunofluorescence to combine magnetic resonance imaging (MRI) and optical imaging approach and genetic targeting of two key genes of the M1- and M2-like phenotypes, iNOS and Ym1, to monitor in vivo the dynamic adaption of the microglia phenotype in response to experimental stroke.
Wed Oct 28 00:00:00 UTC 2020
Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Communications biology
Ji C,Kittredge A,Hopiavuori A,Ward N,Chen S,Fukuda Y,Zhang Y,Yang T
A-6455 was used in Western Blotting to determine the role of the neck and aperture of hBest1 in channel gating.
Thu Apr 23 00:00:00 UTC 2020
Nucleoplasmin is a limiting component in the scaling of nuclear size with cytoplasmic volume.
The Journal of cell biology
Chen P,Tomschik M,Nelson KM,Oakey J,Gatlin JC,Levy DL
A-6455 was used in Immunocytochemistry-immunofluorescence to propose that reductions in cell volume and the amounts of limiting components, such as Npm2, contribute to developmental nuclear size scaling.
Mon Dec 02 00:00:00 UTC 2019
MAPK- and glycogen synthase kinase 3-mediated phosphorylation regulates the DEAD-box protein modulator Gle1 for control of stress granule dynamics.
The Journal of biological chemistry
Mason AC,Sharma M,Dawson TR,Wente SR
A-6455 was used in Western Blotting to show RNA-dependent DEAD-box protein modulator Gle1 can be regulated by MAPK- and glycogen synthase kinase 3-mediated phosphorylation.
Fri Jan 11 00:00:00 UTC 2019
Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies.
G3 (Bethesda, Md.)
Shih MM,Davis FP,Henry GL,Dubnau J
A-6455 was used in Immunohistochemistry to provide a full accounting of the neurotransmitter receptors, transporters, neurotransmitter biosynthetic enzymes, neuropeptides, and neuropeptide receptors expressed within each of these cell types.
Wed Jan 09 00:00:00 UTC 2019
Dual and Opposing Functions of the Central Amygdala in the Modulation of Pain.
Cell reports
Wilson TD,Valdivia S,Khan A,Ahn HS,Adke AP,Martinez Gonzalez S,Sugimura YK,Carrasquillo Y
A-6455 was used in Immunohistochemistry to demonstrate that the central nucleus of the amygdala (CeA) functions as a pain rheostat, decreasing or increasing pain-related behaviors in mice.
Tue Oct 08 00:00:00 UTC 2019
Nppb Neurons Are Sensors of Mast Cell-Induced Itch.
Cell reports
Solinski HJ,Kriegbaum MC,Tseng PY,Earnest TW,Gu X,Barik A,Chesler AT,Hoon MA
A-6455 was used in Immunohistochemistry-immunofluorescence to define a molecular and cellular pathway for mast cell-induced itch by use of natriuretic polypeptide b-expressing class of sensory neurons.
Tue Mar 26 00:00:00 UTC 2019
miR-263b Controls Circadian Behavior and the Structural Plasticity of Pacemaker Neurons by Regulating the LIM-Only Protein Beadex.
Cells
Nian X,Chen W,Bai W,Zhao Z,Zhang Y
A-6455 was used in Immunohistochemistry to establish miR-263b as an important regulator of circadian locomotor behavior and structural plasticity.
Sun Aug 18 00:00:00 UTC 2019
Morphologic determinant of tight junctions revealed by claudin-3 structures.
Nature communications
Nakamura S,Irie K,Tanaka H,Nishikawa K,Suzuki H,Saitoh Y,Tamura A,Tsukita S,Fujiyoshi Y
A-6455 was used in Immunocytochemistry-immunoflourescence to describe the structure of claudin-3 and reveal how it determines the morphology and adhesiveness of tight junctions.
Mon Feb 18 00:00:00 UTC 2019
Differential enhancement of ERK, PKA and Ca2+ signaling in direct and indirect striatal neurons of Parkinsonian mice.
Neurobiology of disease
Mariani LL,Longueville S,Girault JA,Hervé D,Gervasi N
A-6455 was used in Western Blot to reveal distinct cell type-specific signaling alterations in the striatum after dopamine denervation.
Tue Oct 01 00:00:00 UTC 2019
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties.
Cell reports
Foggetti A,Baccini G,Arnold P,Schiffelholz T,Wulff P
A-6455 was used in Immunohistochemistry to show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization.
Tue Jun 25 00:00:00 UTC 2019
Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.
PLoS genetics
Nagy D,Cusumano P,Andreatta G,Anduaga AM,Hermann-Luibl C,Reinhard N,Gesto J,Wegener C,Mazzotta G,Rosato E,Kyriacou CP,Helfrich-Förster C,Costa R
A-6455 was used in Immunocytochemistry to show that Drosophila melanogaster two neuropeptides inhibit reproductive arrest likely through modulation of the insulin producing cells.
Sat Jun 01 00:00:00 UTC 2019
A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis.
eLife
Takahashi N,Ogita N,Takahashi T,Taniguchi S,Tanaka M,Seki M,Umeda M
A-6455 was used in Western Blotting to report that in Arabidopsis, the NAC-type transcription factors ANA044 and ANAC085 are required for DNA damage-induced G2 arrest.
Tue Apr 09 00:00:00 UTC 2019
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.
Nature communications
Matsumoto S,Yamamichi T,Shinzawa K,Kasahara Y,Nojima S,Kodama T,Obika S,Takehara T,Morii E,Okuyama H,Kikuchi A
A-6455 was used in Western Blot to reveal that expression of growth regulation by estrogen in breast cancer 1 depends on Wnt/β-catenin signaling in hepatoblastoma patients.
Wed Aug 28 00:00:00 UTC 2019
Multilevel regulation of the glass locus during Drosophila eye development.
PLoS genetics
Fritsch C,Bernardo-Garcia FJ,Humberg TH,Mishra AK,Miellet S,Almeida S,Frochaux MV,Deplancke B,Huber A,Sprecher SG
A-6455 was used in Immunohistochemistry to study the mechanisms that control expression of Glass.
Mon Jul 01 00:00:00 UTC 2019
Human Sinusoidal Subendothelial Cells Regulate Homing and Invasion of Circulating Metastatic Prostate Cancer Cells to Bone Marrow.
Cancers
Funari A,Alimandi M,Pierelli L,Pino V,Gentileschi S,Sacchetti B
A-6455 was used in Immunohistochemistry to support the hypothesis that BM SSCs committed to a pericyte fate can specify for homing niches of PC cells, suggesting an involvement of specific interactions with subendothelial stromal cells in extravasation of circulating metastatic PC cells to BM.
Fri May 31 00:00:00 UTC 2019
An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms.
eLife
Kanca O,Zirin J,Garcia-Marques J,Knight SM,Yang-Zhou D,Amador G,Chung H,Zuo Z,Ma L,He Y,Lin WW,Fang Y,Ge M,Yamamoto S,Schulze KL,Hu Y,Spradling AC,Mohr SE,Perrimon N,Bellen HJ
A-6455 was used in Western Blotting to describe three new simpler ways to edit genes in flies.
Fri Nov 01 00:00:00 UTC 2019
Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
Stem cell reports
Sato T,Higashioka K,Sakurai H,Yamamoto T,Goshima N,Ueno M,Sotozono C
A-6455 was used in Immunohistochemistry-immunofluorescence to identify four transcription factors which enhance the derivation of PAX3-positive skeletal muscle stem cells with potential therapeutic interest.
Tue Aug 13 00:00:00 UTC 2019
Functional Domains of the Herpes Simplex Virus Type 1 Tegument Protein pUL37: The Amino Terminus is Dispensable for Virus Replication in Tissue Culture.
Viruses
Grzesik P,Pryce EN,Bhalala A,Vij M,Ahmed R,Etienne L,Perez P,McCaffery JM,Desai APJ
A-6455 was used in Western Blotting to determine essential domains and amino acid residues of pUL37 and their associated functions in cellular localization and virion morphogenesis.
Sat Sep 14 00:00:00 UTC 2019
The regulatory pathway from genes directly activated by maternal factors to muscle structural genes in ascidian embryos.
Development (Cambridge, England)
Yu D,Oda-Ishii I,Kubo A,Satou Y
A-6455 was used in ChIP assay to reveal a cross-regulatory circuit among these regulatory factors, which maintains the expression of Tbx6-r.b and Mrf during gastrulation.
Mon Feb 04 00:00:00 UTC 2019
Restorative effects of human neural stem cell grafts on the primate spinal cord.
Nature medicine
Rosenzweig ES,Brock JH,Lu P,Kumamaru H,Salegio EA,Kadoya K,Weber JL,Liang JJ,Moseanko R,Hawbecker S,Huie JR,Havton LA,Nout-Lomas YS,Ferguson AR,Beattie MS,Bresnahan JC,Tuszynski MH
A-6455 was used in Immunohistochemistry-immunofluorescence to show translation neural progenitor cell graft therapy in humans with the objective of reconstituting both a neuronal and a glial milieu in the site of spinal cord injury.
Tue May 01 00:00:00 UTC 2018
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.
Nature medicine
Zhang YJ,Gendron TF,Ebbert MTW,O'Raw AD,Yue M,Jansen-West K,Zhang X,Prudencio M,Chew J,Cook CN,Daughrity LM,Tong J,Song Y,Pickles SR,Castanedes-Casey M,Kurti A,Rademakers R,Oskarsson B,Dickson DW,Hu W,Gitler AD,Fryer JD,Petrucelli L
A-6455 was used in Western Blotting to data suggest that poly(GR) contributes to c9FTD/ALS by impairing protein translation and stress granule dynamics, consequently causing chronic cellular stress and preventing cells from mounting an effective stress response.
Wed Aug 01 00:00:00 UTC 2018
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Nature
Calo E,Gu B,Bowen ME,Aryan F,Zalc A,Liang J,Flynn RA,Swigut T,Chang HY,Attardi LD,Wysocka J
A-6455 was used in Western Blotting to illustrate how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.
Thu Feb 01 00:00:00 UTC 2018
A hypothalamic circuit for the circadian control of aggression.
Nature neuroscience
Todd WD,Fenselau H,Wang JL,Zhang R,Machado NL,Venner A,Broadhurst RY,Kaur S,Lynagh T,Olson DP,Lowell BB,Fuller PM,Saper CB
A-6455 was used in Immunohistochemistry to demonstrate that a daily rhythm in aggression propensity in male mice is gated by GABAergic subparaventricular zone (SPZGABA) neurons, the major postsynaptic targets of the central circadian clock, the suprachiasmatic nucleus.
Tue May 01 00:00:00 UTC 2018
Salicylic acid-induced transcriptional reprogramming by the HAC-NPR1-TGA histone acetyltransferase complex in Arabidopsis.
Nucleic acids research
Jin H,Choi SM,Kang MJ,Yun SH,Kwon DJ,Noh YS,Noh B
A-6455 was used in Chromatin immunoprecipitation to study the molecular mechanism of NPR1-mediated transcriptional reprogramming in Arabidopsis.
Fri Dec 14 00:00:00 UTC 2018
Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses.
Neuron
Kellermayer B,Ferreira JS,Dupuis J,Levet F,Grillo-Bosch D,Bard L,Linarès-Loyez J,Bouchet D,Choquet D,Rusakov DA,Bon P,Sibarita JB,Cognet L,Sainlos M,Carvalho AL,Groc L
A-6455 was used in Immunocytochemistry-immunoflourescence to investigate the nanoscale topography of native GluN2A- and GluN2B NMDA receptors in rat hippocampal synapses.
Wed Oct 10 00:00:00 UTC 2018
Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition.
Neuron
Chiu CQ,Martenson JS,Yamazaki M,Natsume R,Sakimura K,Tomita S,Tavalin SJ,Higley MJ
A-6455 was used in Immunohistochemistry-immunofluorescence to demonstrate that activation of NMDA-type glutamate receptors leads to input-specific long-term potentiation of dendritic inhibition mediated by somatostatin-expressing interneurons.
Wed Jan 17 00:00:00 UTC 2018
Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.
The EMBO journal
Sugo M,Kimura H,Arasaki K,Amemiya T,Hirota N,Dohmae N,Imai Y,Inoshita T,Shiba-Fukushima K,Hattori N,Cheng J,Fujimoto T,Wakana Y,Inoue H,Tagaya M
A-6455 was used in Western Blotting to show that the function and localisation of PGAM5 are regulated by syntaxin 17, a mitochondria-associated membrane/mitochondria protein implicated in mitochondrial dynamics in fed cells and autophagy in starved cells.
Fri Nov 02 00:00:00 UTC 2018
JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche.
Molecular psychiatry
Mohammad H,Marchisella F,Ortega-Martinez S,Hollos P,Eerola K,Komulainen E,Kulesskaya N,Freemantle E,Fagerholm V,Savontaus E,Rauvala H,Peterson BD,van Praag H,Coffey ET
A6455 was used in immunohistochemistry - free floating to report a role for JNK in the hippocampal neurogenic niche and anxiety behavior
Thu Feb 01 00:00:00 UTC 2018
Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.
Developmental cell
Alpar L,Bergantiños C,Johnston LA
A-6455 was used in Western Blotting to identify Spz processing enzyme and modular serine protease as activators of Spz-regulated competitive signalling and show that "winner" cells trigger elimination of nearby WT cells by boosting SPE production.
Mon Sep 24 00:00:00 UTC 2018
Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
Genes & development
Boisclair Lachance JF,Webber JL,Hong L,Dinner AR,Rebay I
A-6455 was used in Immunohistochemistry-immunofluorescence to study the mechanism by which differential interpretation of cis-regulatory modules syntax can confer specificity and robustness of developmental transitions.
Thu Mar 01 00:00:00 UTC 2018
Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.
Genes & development
Kim J,Bilder D,Neufeld TP
A-6455 was used in Western Blotting to suggest that regulation of insulin sensitivity by mechanical stress may help coordinate developmental programming with metabolism.
Mon Jan 15 00:00:00 UTC 2018
GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.
Proceedings of the National Academy of Sciences of the United States of America
Rifkin RA,Huyghe D,Li X,Parakala M,Aisenberg E,Moss SJ,Slesinger PA
A-6455 was used in Immunohistochemistry-immunofluorescence to investigate the role of G protein-gated inwardly rectifying potassium channels (GIRK) in reward circuits by using sorting nexin 27 (SNX27), an endosomal adaptor protein that is associated with GIRK2c and GIRK3 subunits.
Tue Oct 02 00:00:00 UTC 2018
Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an Unconventional Route for Replication Vesicle Trafficking.
The Plant cell
Cabanillas DG,Jiang J,Movahed N,Germain H,Yamaji Y,Zheng H,Laliberté JF
A-6455 was used in Western Blotting to determine that turnip mosaic virus replication vesicles bypass the Golgi apparatus by using SNARE protein VTI11 to take an unconventional pathway.
Mon Oct 01 00:00:00 UTC 2018
NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting.
Aging cell
Goh GYS,Winter JJ,Bhanshali F,Doering KRS,Lai R,Lee K,Veal EA,Taubert S
A-6455 was used in Western Blotting to establish a new role for the HNF4/PPARα-related NHR-49 as a stress-activated regulator of cytoprotective gene expression.
Fri Jun 01 00:00:00 UTC 2018
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.
Current biology : CB
Gelegen C,Miracca G,Ran MZ,Harding EC,Ye Z,Yu X,Tossell K,Houston CM,Yustos R,Hawkins ED,Vyssotski AL,Dong HL,Wisden W,Franks NP
A-6455 was used in Immunohistochemistry to conclude that the glutamatergic output from the lateral habenula is permissive for the sedative actions of propofol and is also necessary for the consolidation of natural sleep.
Mon Feb 19 00:00:00 UTC 2018
Brassinosteroids Dominate Hormonal Regulation of Plant Thermomorphogenesis via BZR1.
Current biology : CB
Ibañez C,Delker C,Martinez C,Bürstenbinder K,Janitza P,Lippmann R,Ludwig W,Sun H,James GV,Klecker M,Grossjohann A,Schneeberger K,Prat S,Quint M
A-6455 was used in Western Blotting to identify BZR1 here as a true temperature-dependent positive regulator of PIF4, acting as a major growth coordinator.
Mon Jan 22 00:00:00 UTC 2018
The Claustrum Supports Resilience to Distraction.
Current biology : CB
Atlan G,Terem A,Peretz-Rivlin N,Sehrawat K,Gonzales BJ,Pozner G,Tasaka GI,Goll Y,Refaeli R,Zviran O,Lim BK,Groysman M,Goshen I,Mizrahi A,Nelken I,Citri A
A-6455 was used in Immunohistochemistry to describe the use of Egr2-CRE mice to access genetically-defined claustral neurons.
Mon Sep 10 00:00:00 UTC 2018
Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change.
Current biology : CB
Nagy O,Nuez I,Savisaar R,Peluffo AE,Yassin A,Lang M,Stern DL,Matute DR,David JR,Courtier-Orgogozo V
A-6455 was used in Western Blotting to show that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits.
Mon Nov 05 00:00:00 UTC 2018
Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion.
Glia
Begolly S,Olschowka JA,Love T,Williams JP,O'Banion MK
A-6455 was used in Immunohistochemistry to demonstrate that fractionation does not spare normal brain tissue and, importantly, highlights the sensitivity of OPCs to fractionated IR, suggesting that fractionated schedules may promote white matter dysfunction, a point that should be considered in radiotherapy.
Sun Apr 01 00:00:00 UTC 2018
CHLOROPLAST RIBOSOME ASSOCIATED Supports Translation under Stress and Interacts with the Ribosomal 30S Subunit.
Plant physiology
Pulido P,Zagari N,Manavski N,Gawronski P,Matthes A,Scharff LB,Meurer J,Leister D
A-6455 was used in RNA Immunoprecipitation to report on the finding of a new protein called CRASS which plays a role in the biogenesis and/or stability of the chloroplast ribosome that becomes critical under certain stressful conditions when ribosomal activity is compromised.
Wed Aug 01 00:00:00 UTC 2018
Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.
PLoS pathogens
Haas DA,Meiler A,Geiger K,Vogt C,Preuss E,Kochs G,Pichlmair A
A-6455 was used in Western Blotting to show targeting of TFIIB by THOV represents a neat mechanism to affect immune responses while keeping other cellular transcriptional activities intact to control inflammation.
Sun Apr 01 00:00:00 UTC 2018
Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Development (Cambridge, England)
Webber JL,Zhang J,Massey A,Sanchez-Luege N,Rebay I
A-6455 was used in Chromatin immunoprecipitation to establish that Yan and Pointed co-occupy regulatory elements to repress gene expression with coordination.
Mon Jul 02 00:00:00 UTC 2018
Perturbation of canonical and non-canonical BMP signaling affects migration, polarity and dendritogenesis of mouse cortical neurons.
Development (Cambridge, England)
Saxena M,Agnihotri N,Sen J
A-6455 was used in Immunohistochemistry-immunofluorescence to reveal that BMP signaling specifically regulates the migration, polarity and the dendritic morphology of upper layer cortical neurons born at E15.5.
Tue Jan 09 00:00:00 UTC 2018
Growth control through regulation of insulin signalling by nutrition-activated steroid hormone in Drosophila.
Development (Cambridge, England)
Buhler K,Clements J,Winant M,Bolckmans L,Vulsteke V,Callaerts P
A-6455 was used in Immunohistochemistry-immunofluorescence to study the mechanisms underlying growth and their coordination in Drosophila.
Fri Nov 02 00:00:00 UTC 2018
Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jiang Z,Rajamanickam S,Justice NJ
A-6455 was used in Immunohistochemistry-immunofluorescence to characterize the electrophysiological and molecular properties of paraventricular nucleus-CRFR1 neurons and study their monosynaptic connectivity.
Wed Feb 21 00:00:00 UTC 2018
Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Warikoo N,Brunwasser SJ,Benz A,Shu HJ,Paul SM,Lewis M,Doherty J,Quirk M,Piccio L,Zorumski CF,Day GS,Mennerick S
A-6455 was used in Immunocytochemistry-immunoflourescence to characterise the functional consequences of exposure to CSF from female human NMDARE patients on NMDAR function, and the effects of intervention with positive allosteric modulators of NMDARs.
Wed Mar 28 00:00:00 UTC 2018
A Multicomponent Neuronal Response Encodes the Larval Decision to Pupariate upon Amino Acid Starvation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jayakumar S,Richhariya S,Deb BK,Hasan G
A-6455 was used in Immunohistochemistry to demonstrate that nutritional deprivation, in postcritical weight larvae, is sensed by special sensory neurons through an amino acid transporter that detects loss of environmental arginine.
Wed Nov 21 00:00:00 UTC 2018
Importin-8 Modulates Division of Apical Progenitors, Dendritogenesis and Tangential Migration During Development of Mouse Cortex.
Frontiers in molecular neuroscience
Nganou G,Silva CG,Gladwyn-Ng I,Engel D,Coumans B,Delgado-Escueta AV,Tanaka M,Nguyen L,Grisar T,de Nijs L,Lakaye B
A-6455 was used in Immunohistochemistry to study the role of Β-importin, importin-8 during mouse cerebral corticogenesis.
Thu Oct 01 00:00:00 UTC 2020
Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.
RNA (New York, N.Y.)
Coll O,Guitart T,Villalba A,Papin C,Simonelig M,Gebauer F
A-6455 was used in Western Blotting to discover Dicer-2 has a novel function in activation of mRNA translation through cytoplasmic polyadenylation.
Sun Apr 01 00:00:00 UTC 2018
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
Journal of cell science
Takahashi K,Nagai T,Chiba S,Nakayama K,Mizuno K
A-6455 was used in Western Blotting to indicate that glucose deprivation promotes primary cilium formation through mTORC1 inactivation.
Mon Jan 08 00:00:00 UTC 2018
Direct binding of Talin to Rap1 is required for cell-ECM adhesion in Drosophila.
Journal of cell science
Camp D,Haage A,Solianova V,Castle WM,Xu QA,Lostchuck E,Goult BT,Tanentzapf G
A-6455 was used in Immunohistochemistry to reveal that the direct binding of Talin to Rap1 is essential for the regulation of cell-extracellular matrix adhesion in Drosophila.
Tue Dec 18 00:00:00 UTC 2018
A Role in Apoptosis Regulation for the rad-51 Gene of Caenorhabditis elegans.
Genetics
Germoglio M,Adamo A
A-6455 was used in Immunofluorescence in immunohistochemistry on frozen tissues to suggest that in the nematode Caenorhabditis elegans RAD-51 plays a novel role in germ line apoptosis independent of RAD-51-mediated strand invasion for homologous recombination.
Wed Aug 01 00:00:00 UTC 2018
Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.
Developmental biology
Hockman D,Adameyko I,Kaucka M,Barraud P,Otani T,Hunt A,Hartwig AC,Sock E,Waithe D,Franck MCM,Ernfors P,Ehinger S,Howard MJ,Brown N,Reese J,Baker CVH
A-6455 was used in Immunohistochemistry to resolve a paradox for the emigre hypothesis in the chicken - where the nearest ganglion to the carotid body is the nodose, in which the satellite glia are neural crest-derived, but the neurons are almost entirely placode-derived - by fate-mapping putative nodose neuronal emigres to the neural crest.
Sat Dec 01 00:00:00 UTC 2018
Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes.
Developmental biology
Newman EA,Kim DW,Wan J,Wang J,Qian J,Blackshaw S
A-6455 was used in Immunohistochemistry to study the transcriptional networks that control hypothalamus development.
Sun Jul 15 00:00:00 UTC 2018
The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum.
Developmental biology
Womble M,Amin NM,Nascone-Yoder N
A-6455 was used in Immunohistochemistry to study, using a Xenopus laevis model, how Pitx2c-dependent development of asymmetrical lobation in the vertebrate liver occurs.
Sun Jul 15 00:00:00 UTC 2018
The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila.
Frontiers in genetics
Zheng Y,Xue Y,Ren X,Liu M,Li X,Jia Y,Niu Y,Ni JQ,Zhang Y,Ji JY
A-6455 was used in Immunohistochemistry to study the role of mammalian lysine-specific demethylase2 homologs during development.
Wed Jul 24 00:00:00 UTC 2024
FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster.
PLoS genetics
Ravi P,Trivedi D,Hasan G
A-6455 was used in Immunohistochemistry to investigate modulation of insect flight by FMRFa we generated CRISPR-Cas9 mutants in the gene encoding the Drosophila FMRFaR.
Wed Aug 01 00:00:00 UTC 2018
Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons.
Scientific reports
Barrio-Alonso E,Hernández-Vivanco A,Walton CC,Perea G,Frade JM
A-6455 was used in Immunocytochemistry-immunoflourescence to demonstrate that cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons.
Tue Sep 25 00:00:00 UTC 2018
Adult neurogenic deficits in HIV-1 Tg26 transgenic mice.
Journal of neuroinflammation
Putatunda R,Zhang Y,Li F,Yang XF,Barbe MF,Hu W
A-6455 was used in Immunohistochemistry to characterise the effects of all the combined HIV viral proteins on adult neurogenesis.
Fri Oct 12 00:00:00 UTC 2018
Nuclear factor-kappaB regulates multiple steps of gliogenesis in the developing murine cerebral cortex.
Glia
Methot L,Soubannier V,Hermann R,Campos E,Li S,Stifani S
A-6455 was used in Immunohistochemistry to reveal a number of previously uncharacterized roles for nuclear factor-kappaB (NF-κB) during different phases of neocortical gliogenesis and identify NF-κB as an inhibitor of early oligodendrocyte development in the cerebral cortex.
Sat Dec 01 00:00:00 UTC 2018
Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception.
American journal of clinical and experimental immunology
Han DJ,He ZG,Yang H
A-6455 was used in Immunohistochemistry-immunofluorescence to contribute to the view of melanocortinergic-opioidergic circuits in the subthalamic nucleus as a reliable source of modulating of nociception with therapeutic potential for alleviating pain.
Thu Oct 01 00:00:00 UTC 2020
Spatio-temporal relays control layer identity of direction-selective neuron subtypes in Drosophila.
Nature communications
Apitz H,Salecker I
A-6455 was used in Immunohistochemistry-immunofluorescence to investigate if diffusible Wingless (Wg) between adjacent neuroepithelia induces its own expression to form secondary signaling centers.
Tue Jun 12 00:00:00 UTC 2018
Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy.
Nature communications
Yamaguchi N,Huang J,Tatsumi Y,Abe M,Sugano SS,Kojima M,Takebayashi Y,Kiba T,Yokoyama R,Nishitani K,Sakakibara H,Ito T
A-6455 was used in Chromatin immunoprecipitation to provide new insight into the CRC-mediated auxin homeostasis regulation for proper gynoecium formation.
Tue Dec 11 00:00:00 UTC 2018
A comprehensive anatomical map of the peripheral octopaminergic/tyraminergic system of Drosophila melanogaster.
Scientific reports
Pauls D,Blechschmidt C,Frantzmann F,El Jundi B,Selcho M
A-6455 was used in Immunohistochemistry-immunofluorescence to comprehensively map the entire octopaminergic/tyraminergic circuitry system in the Drosophila melanogaster body.
Wed Oct 17 00:00:00 UTC 2018
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Nature communications
Rivat C,Sar C,Mechaly I,Leyris JP,Diouloufet L,Sonrier C,Philipson Y,Lucas O,Mallié S,Jouvenel A,Tassou A,Haton H,Venteo S,Pin JP,Trinquet E,Charrier-Savournin F,Mezghrani A,Joly W,Mion J,Schmitt M,Pattyn A,Marmigère F,Sokoloff P,Carroll P,Rognan D,Valmier J
A-6455 was used in Immunohistochemistry to suggest a new and specific therapeutic approach for PNP.
Mon Mar 12 00:00:00 UTC 2018
ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.
EMBO reports
Hazawa M,Lin DC,Kobayashi A,Jiang YY,Xu L,Dewi FRP,Mohamed MS,Nakada M,Meguro-Horike M,Horike SI,Koeffler HP,Wong RW
A-6455 was used in Western Blot to find that differentiation-inducible Rho kinase reduces the interaction between NUP62 and ΔNp63α by phosphorylation of phenylalanine-glycine regions of NUP62, attenuating ΔNp63α nuclear import.
Mon Jan 01 00:00:00 UTC 2018
Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.
Science advances
Castle MJ,Cheng Y,Asokan A,Tuszynski MH
A-6455 was used in Immunohistochemistry to provide a novel and simple method for broad gene delivery to the cortex and are of substantial relevance to translational programs for neurological disorders like Alzheimer's disease and stroke.
Thu Nov 01 00:00:00 UTC 2018
Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.
Cell reports
Martín-García R,Arribas V,Coll PM,Pinar M,Viana RA,Rincón SA,Correa-Bordes J,Ribas JC,Pérez P
A-6455 was used in Western Blot to suggest the existence of a positive feedback loop between Pxl1 and CN and establish that Pxl1 is a crucial component of the CN signaling pathway during cytokinesis.
Tue Oct 16 00:00:00 UTC 2018
Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling.
Cell reports
Keskin S,Devakanmalai GS,Kwon SB,Vu HT,Hong Q,Lee YY,Soltani M,Singh A,Ay A,Özbudak EM
A-6455 was used in Immunohistochemistry to investigate the source and buffering mechanism of expression variability, and study a biological clock, the vertebrate segmentation clock, controlling the precise spatiotemporal patterning of the vertebral column.
Tue May 15 00:00:00 UTC 2018
Features of the structure, development, and activity of the zebrafish noradrenergic system explored in new CRISPR transgenic lines.
The Journal of comparative neurology
Farrar MJ,Kolkman KE,Fetcho JR
A-6455 was used in Immunohistochemistry to show interhemispheric asynchrony, supporting the potential for targeted LC neuromodulation.
Mon Oct 15 00:00:00 UTC 2018
Engineering human pluripotent stem cells into a functional skeletal muscle tissue.
Nature communications
Rao L,Qian Y,Khodabukus A,Ribar T,Bursac N
A-6455 was used in Immunocytochemistry-immunoflourescence to generate functional skeletal muscle tissues from human pluripotent stem cells.
Tue Jan 09 00:00:00 UTC 2018
The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons.
Developmental biology
Lin JM,Taroc EZM,Frias JA,Prasad A,Catizone AN,Sammons MA,Forni PE
A-6455 was used in Immunohistochemistry to demonstrate that AP-2ε controls the terminal differentiation and homeostasis of basal VSNs by repressing gene expression from the apical genetic program.
Sat Sep 01 00:00:00 UTC 2018
Subtype-specific response of retinal ganglion cells to optic nerve crush.
Cell death discovery
Daniel S,Clark AF,McDowell CM
A-6455 was used in Immunohistochemistry-immunofluorescence to study the response of 4 retinal ganglion cell subtypes in a model of optic nerve crush.
Wed Jul 17 00:00:00 UTC 2024
Subtype-specific response of retinal ganglion cells to optic nerve crush.
Cell death discovery
Daniel S,Clark AF,McDowell CM
A-6455 was used in Immunohistochemistry-immunofluorescence to study the response of 4 retinal ganglion cell subtypes in a model of optic nerve crush.
Wed Jul 17 00:00:00 UTC 2024
Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse.
Journal of neuroendocrinology
Kokay IC,Wyatt A,Phillipps HR,Aoki M,Ectors F,Boehm U,Grattan DR
A-6455 was used in Immunohistochemistry to develop a novel reporter mouse line which targets Prlr expression within murine brain, with high specificity and without the need of GFP signal amplification.
Sat Sep 01 00:00:00 UTC 2018
Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs.
The Journal of cell biology
Hung YF,Chen CY,Shih YC,Liu HY,Huang CM,Hsueh YP
A-6455 was used in Immunohistochemistry to show that TLR8, TLR7, and TLR3 promote dendritic pruning via MYD88 signaling.
Mon Aug 06 00:00:00 UTC 2018
Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.
PloS one
Fujiwara S,Matsui TS,Ohashi K,Deguchi S,Mizuno K
A-6455 was used in Western blotting to show that Solo, a guanine nucleotide exchange factor targeting RhoA, co-precipitates with an HD protein, Β4-integrin.
Mon Jul 16 00:00:00 UTC 2018
Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.
Journal of neurochemistry
Kunisawa K,Shimizu T,Kushima I,Aleksic B,Mori D,Osanai Y,Kobayashi K,Taylor AM,Bhat MA,Hayashi A,Baba H,Ozaki N,Ikenaka K
A-6455 was used in Immunohistochemistry to provide new insights into therapeutic approaches for SCZ by regulating AQP3 expression, which is associated with paranodal disruption.
Thu Nov 01 00:00:00 UTC 2018
Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility.
PloS one
Laursen SB,Finsen S,Marcussen N,Quaggin SE,Hansen PBL,Dimke H
A-6455 was used in Immunohistochemistry to investigate the effects of deletion of the mineralocorticoid receptors expressed in endothelial cells on the renal vasculature: no alterations to blood pressure, kidney function or renal vessel contractility were observed.
Wed May 23 00:00:00 UTC 2018
Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish.
Cell reports
Simsek MF,Özbudak EM
A-6455 was used in Immunohistochemistry to develop a non-elongating tail explant system, integrated quantitative measurements with computational modeling and test alternative models to show that positional information is encoded solely by spatial fold change in fibroblast growth factor signal output.
Tue Jul 03 00:00:00 UTC 2018
Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons.
PLoS genetics
Tas D,Stickley L,Miozzo F,Koch R,Loncle N,Sabado V,Gnägi B,Nagoshi E
A-6455 was used in Immunohistochemistry to study the role of forkhead box proteins in the death of dopaminergic neurons.
Thu Mar 01 00:00:00 UTC 2018
The complete connectome of a learning and memory centre in an insect brain.
Nature
Eichler K,Li F,Litwin-Kumar A,Park Y,Andrade I,Schneider-Mizell CM,Saumweber T,Huser A,Eschbach C,Gerber B,Fetter RD,Truman JW,Priebe CE,Abbott LF,Thum AS,Zlatic M,Cardona A
A-6455 was used in Immunocytochemistry to create a complete circuit network of a Drosophila mushroom body for future memory and learning studies.
Wed Aug 09 00:00:00 UTC 2017
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
Cancer cell
Zhu S,Zhang X,Weichert-Leahey N,Dong Z,Zhang C,Lopez G,Tao T,He S,Wood AC,Oldridge D,Ung CY,van Ree JH,Khan A,Salazar BM,Lummertz da Rocha E,Zimmerman MW,Guo F,Cao H,Hou X,Weroha SJ,Perez-Atayde AR,Neuberg DS,Meves A,McNiven MA,van Deursen JM,Li H,Maris JM,Look AT
A-6455 was used in Immunohistochemistry to provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination.
Mon Sep 11 00:00:00 UTC 2017
Serotonergic Projections Govern Postnatal Neuroblast Migration.
Neuron
García-González D,Khodosevich K,Watanabe Y,Rollenhagen A,Lübke JHR,Monyer H
A-6455 was used in Immunohistochemistry-immunofluorescence to identify a serotonergic mechanism that governs migration of postnatally generated neurons in the mouse brain.
Wed May 03 00:00:00 UTC 2017
Developing Spindlin1 small-molecule inhibitors by using protein microarrays.
Nature chemical biology
Bae N,Viviano M,Su X,Lv J,Cheng D,Sagum C,Castellano S,Bai X,Johnson C,Khalil MI,Shen J,Chen K,Li H,Sbardella G,Bedford MT
A-6455 was used in Chromatin immunoprecipitation to structurally study the rational synthesis of SPIN1 inhibitors.
Sat Jul 01 00:00:00 UTC 2017
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.
The EMBO journal
Nishimura T,Tamura N,Kono N,Shimanaka Y,Arai H,Yamamoto H,Mizushima N
A-6455 was used in Western Blotting to study the role of the endoplasmic reticulum membrane is involved in autophagy initiation and to which membrane structures the autophagy initiation complex is localised.
Wed Jun 14 00:00:00 UTC 2017
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.
Developmental cell
Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H
A-6455 was used in Immunohistochemistry to demonstrate that ML1, acting as a Ca2+ channel in TVs, links transmitter-initiated cyclic nucleotide signaling with Ca2+-dependent TV exocytosis in parietal cells, providing a regulatory mechanism that could be targeted to manage acid-related gastric diseases.
Mon May 08 00:00:00 UTC 2017
Difference in Dachsous Levels between Migrating Cells Coordinates the Direction of Collective Cell Migration.
Developmental cell
Arata M,Sugimura K,Uemura T
A-6455 was used in Immunohistochemistry-immunofluorescence to study the collective migration of Drosophila larval epidermal cells along the anterior-posterior axis and propose a migrating cell group-autonomous mechanism in which an atypical cadherin Dachsous plays a pivotal role.
Mon Sep 11 00:00:00 UTC 2017
Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.
EMBO reports
Ioannou MS,Kulasekaran G,Fotouhi M,Morein JJ,Han C,Tse S,Nossova N,Han T,Mannard E,McPherson PS
A-6455 was used in Western Blot to uncover a novel mechanism of internalized epidermal growth factor receptor processing.
Fri Dec 01 00:00:00 UTC 2017
Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary.
Development (Cambridge, England)
Huang J,Reilein A,Kalderon D
A-6455 was used in Immunohistochemistry to show that for Drosophila germarium in escort cells, both Hh and Yki limit production of BMP ligands to allow germline differentiation.
Sat Jul 15 00:00:00 UTC 2017
Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster.
Development (Cambridge, England)
Shukla JP,Deshpande G,Shashidhara LS
A-6455 was used in Immunohistochemistry-immunofluorescence to propose a model explaining the requirement of A2BP1 as a positive regulator of context-specific Notch activity.
Wed Mar 01 00:00:00 UTC 2017
Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo.
Development (Cambridge, England)
Acloque H,Ocaña OH,Abad D,Stern CD,Nieto MA
A-6455 was used in Immunohistochemistry-immunofluorescence to show that in a chick embryo, E-cadherin is weakly expressed in the epiblast at pre-primitive streak stages where it is substituted for by P-cadherin.
Wed Feb 15 00:00:00 UTC 2017
βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Efimova N,Korobova F,Stankewich MC,Moberly AH,Stolz DB,Wang J,Kashina A,Ma M,Svitkina T
A-6455 was used in Immunocytochemistry-immunoflourescence to show the formation of the constricted neck in dendritic spines is promoted by βIII spectrin and thus βIII spectrin mutations can modulate synaptic strength.
Wed Jul 05 00:00:00 UTC 2017
After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gomez-Sanchez JA,Pilch KS,van der Lans M,Fazal SV,Benito C,Wagstaff LJ,Mirsky R,Jessen KR
A-6455 was used in Immunocytochemistry-immunoflourescence to show that the generation of these repair-supportive Schwann cells involves an extensive cellular elongation and branching, often to form long, parallel processes.
Wed Sep 13 00:00:00 UTC 2017
Spike and Neuropeptide-Dependent Mechanisms Control GnRH Neuron Nerve Terminal Ca2+ over Diverse Time Scales.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Iremonger KJ,Porteous R,Herbison AE
A-6455 was used in Immunohistochemistry to determine the mechanisms by which neurendocrine nerve terminal Ca2+ can be controlled in the brain.
Wed Mar 22 00:00:00 UTC 2017
A Delay between Motor Cortex Lesions and Neuronal Transplantation Enhances Graft Integration and Improves Repair and Recovery.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Péron S,Droguerre M,Debarbieux F,Ballout N,Benoit-Marand M,Francheteau M,Brot S,Rougon G,Jaber M,Gaillard A
A-6455 was used in Immunohistochemistry to demonstrate that a 1 week delay between the lesion and transplantation significantly enhances graft vascularization, survival, proliferation, and the density of the projections developed by grafted neurons.
Wed Feb 15 00:00:00 UTC 2017
Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Farca Luna AJ,Perier M,Seugnet L
A-6455 was used in Immunohistochemistry-immunofluorescence to associate glutamate recycling and sleep regulation, adding further complexity to the physiological role of App and to its implication in AD.
Wed Apr 19 00:00:00 UTC 2017
Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.
Molecular cancer therapeutics
Haak AJ,Appleton KM,Lisabeth EM,Misek SA,Ji Y,Wade SM,Bell JL,Rockwell CE,Airik M,Krook MA,Larsen SD,Verhaegen M,Lawlor ER,Neubig RR
A-6455 was used in Immunohistochemistry to study the role of Rho and MRTF signaling in in vitro and in vivo models of human melanoma growth and metastasis.
Sun Jan 01 00:00:00 UTC 2017
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins.
Frontiers in chemistry
Hellinger R,Thell K,Vasileva M,Muhammad T,Gunasekera S,Kümmel D,Göransson U,Becker CW,Gruber CW
A-6455 was used in Western Blot to determine a target for the circular peptide [T20K]kalata B1.
Wed Dec 11 00:00:00 UTC 2024
The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.
Journal of cell science
Huang HW,Zeng X,Rhim T,Ron D,Ryoo HD
A-6455 was used in Immunohistochemistry to discover that specific regions of the developing alimentary canal, fat body and the male reproductive organ are sources of physiological stress that require Ire1 and Xbp1 for resolution.
Fri Sep 15 00:00:00 UTC 2017
The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.
Journal of cell science
Breznau EB,Murt M,Blasius TL,Verhey KJ,Miller AL
A-6455 was used in Immunohistochemistry-immunofluorescence to propose that the MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Mon May 15 00:00:00 UTC 2017
Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
Journal of cell science
Pérez-Moreno JJ,Espina-Zambrano AG,García-Calderón CB,Estrada B
A-6455 was used in Immunohistochemistry to show how integrins and transmembrane proteoglycans are regulated and coordinated.
Wed Mar 01 00:00:00 UTC 2017
The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.
Journal of cell science
Gödderz D,Giovannucci TA,Laláková J,Menéndez-Benito V,Dantuma NP
A-6455 was used in Western Blotting to suggest that ubiquitylation of Rad23 plays a stimulatory role in the degradation of ubiquitylated substrates by the proteasome.
Sun Oct 01 00:00:00 UTC 2017
In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes.
Plant & cell physiology
Vermeer JEM,van Wijk R,Goedhart J,Geldner N,Chory J,Gadella TWJ,Munnik T
A-6455 was used in Western Blotting to validate the use of a genetically encoded DAG biosensor in living plant cells.
Sat Jul 01 00:00:00 UTC 2017
Pervasive Behavioral Effects of MicroRNA Regulation in Drosophila.
Genetics
Picao-Osorio J,Lago-Baldaia I,Patraquim P,Alonso CR
A-6455 was used in Immunocytochemistry to study early larval self-righting behavior in a collection of 81 Drosophila miRNA mutants covering almost the entire miRNA complement of the late embryo.
Sat Jul 01 00:00:00 UTC 2017
A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1.
Biochemical and biophysical research communications
Takahashi K,Okabe H,Kanno SI,Nagai T,Mizuno K
A-6455 was used in immunoprecipitation and western blot to analyze the structure of Slingshot-1
Sun Jan 22 00:00:00 UTC 2017
* Tissue Engineering Strategies to Improve Osteogenesis in the Juvenile Swine Alveolar Cleft Model.
Tissue engineering. Part C, Methods
Caballero M,Jones DC,Shan Z,Soleimani S,van Aalst JA
A-6455 was used in Immunohistochemistry on paraffin embedded tissues to demonstrate that implanted scaffolds are at least as good as the current gold standard treatment based on harvesting cancellous bone from the iliac crest.
Fri Dec 01 00:00:00 UTC 2017
Mapping synaptic cortico-claustral connectivity in the mouse.
The Journal of comparative neurology
Atlan G,Terem A,Peretz-Rivlin N,Groysman M,Citri A
A-6455 was used in immunohistochemistry - free floating to utilize synaptic cortico-claustral connectivity mapping in the mouse
Sat Apr 15 00:00:00 UTC 2017
Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.
Cell reports
Karmakar K,Narita Y,Fadok J,Ducret S,Loche A,Kitazawa T,Genoud C,Di Meglio T,Thierry R,Bacelo J,Lüthi A,Rijli FM
A-6455 was used in Immunohistochemistry to determine the role of Hox factors in tonotopic refinement of connectivity in the mammalian auditory circuit.
Tue Jan 03 00:00:00 UTC 2017
Midbrain circuit regulation of individual alcohol drinking behaviors in mice.
Nature communications
Juarez B,Morel C,Ku SM,Liu Y,Zhang H,Montgomery S,Gregoire H,Ribeiro E,Crumiller M,Roman-Ortiz C,Walsh JJ,Jackson K,Croote DE,Zhu Y,Zhang S,Vendruscolo LF,Edwards S,Roberts A,Hodes GE,Lu Y,Calipari ES,Chaudhury D,Friedman AK,Han MH
A-6455 was used in Immunohistochemistry to explore, using in vivo electrophysiological techniques, the response of midbrain regions to different levels of alcohol drinking in mice.
Wed Dec 20 00:00:00 UTC 2017
ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility.
Journal of cell science
Luo W,Janoštiak R,Tolde O,Ryzhova LM,Koudelková L,Dibus M,Brábek J,Hanks SK,Rosel D
A-6455 was used in Western Blot to elucidate the regulation of ARHGAP42 variants in mammalian cells.
Sat Jul 15 00:00:00 UTC 2017
Cells from subcutaneous tissues contribute to scarless skin regeneration in Xenopus laevis froglets.
Developmental dynamics : an official publication of the American Association of Anatomists
Otsuka-Yamaguchi R,Kawasumi-Kita A,Kudo N,Izutsu Y,Tamura K,Yokoyama H
A-6455 was used in Immunohistochemistry to investigate scarless skin regeneration in Xenopus laevis.
Tue Aug 01 00:00:00 UTC 2017
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis.
The Journal of biological chemistry
Abe S,Nagai T,Masukawa M,Okumoto K,Homma Y,Fujiki Y,Mizuno K
A-6455 was used in Western Blotting to determine the mechanism underlying the functional difference between nuclear Dbf2-related kinases 1 and 2 in ciliogenesis.
Fri Mar 10 00:00:00 UTC 2017
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis.
The Journal of biological chemistry
Abe S,Nagai T,Masukawa M,Okumoto K,Homma Y,Fujiki Y,Mizuno K
A-6455 was used in Western Blotting to determine the mechanism underlying the functional difference between nuclear Dbf2-related kinases 1 and 2 in ciliogenesis.
Fri Mar 10 00:00:00 UTC 2017
Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: A novel sex difference revealed in the rostral periventricular hypothalamus.
Neuroscience
Rosinger ZJ,Jacobskind JS,Park SG,Justice NJ,Zuloaga DG
A-6455 was used in Immunohistochemistry to investigate sex differences in corticotropin-releasing factor and its receptor.
Wed Oct 11 00:00:00 UTC 2017
Feedback amplification loop drives malignant growth in epithelial tissues.
Proceedings of the National Academy of Sciences of the United States of America
Muzzopappa M,Murcia L,Milán M
A-6455 was used in Immunohistochemistry-immunofluorescence to unravel the existence of a tumor-intrinsic-and microenvironment-independent-self-reinforcement mechanism that drives tumor initiation and growth in an Eiger-independent manner.
Tue Aug 29 00:00:00 UTC 2017
N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.
Journal of Huntington's disease
Chen MZ,Mok SA,Ormsby AR,Muchowski PJ,Hatters DM
A-6455 was used in Western Blotting to investigate the fundamental intracellular aggregation process of eight different-length N-terminal fragments of Htt in both short (25Q) and long polyQ (97Q).
Mon Oct 23 00:00:00 UTC 2017
Strict Independence of Parallel and Poly-synaptic Axon-Target Matching during Visual Reflex Circuit Assembly.
Cell reports
Seabrook TA,Dhande OS,Ishiko N,Wooley VP,Nguyen PL,Huberman AD
A-6455 was used in Immunohistochemistry to discover that axon-target matching is tightly regulated, pointing to a model in which poly-synaptic circuit development reflects independent, highly stringent wiring of each parallel pathway and downstream station.
Tue Dec 12 00:00:00 UTC 2017
A map of sensilla and neurons in the taste system of drosophila larvae.
The Journal of comparative neurology
Rist A,Thum AS
A-6455 was used in Immunohistochemistry-immunofluorescence to perform a systematic anatomical and molecular analysis of the terminal organ (TO) in the Drosophila melanogaster larvae prime site of external taste reception to define morphological subtypes of TO sensilla.
Fri Dec 15 00:00:00 UTC 2017
Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.
Nature communications
Selcho M,Millán C,Palacios-Muñoz A,Ruf F,Ubillo L,Chen J,Bergmann G,Ito C,Silva V,Wegener C,Ewer J
A-6455 was used in Immunohistochemistry-immunofluorescence to show the use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
Tue May 30 00:00:00 UTC 2017
Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.
Scientific reports
Ikeda M,Tanaka K
A-6455 was used in Immunoprecipitation to reveal an intricate mechanism for coordinating the formation of stable kinetochore-microtubule attachment and SAC activity.
Fri Aug 18 00:00:00 UTC 2017
Localization-based super-resolution imaging meets high-content screening.
Nature methods
Beghin A,Kechkar A,Butler C,Levet F,Cabillic M,Rossier O,Giannone G,Galland R,Choquet D,Sibarita JB
A-6455 was used in Stochastic Optical Reconstruction Microscopy Imaging to demonstrate a method compatible with high-content screening using 3D dSTORM and DNA-PAINT based super-resolution microscopy as well as single-particle tracking.
Fri Dec 01 00:00:00 UTC 2017
A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury.
Frontiers in cellular neuroscience
Koch M,Nicolas M,Zschaetzsch M,de Geest N,Claeys A,Yan J,Morgan MJ,Erfurth ML,Holt M,Schmucker D,Hassan BA
A-6455 was used in Immunohistochemistry to study inducers of axonal growth after injury.
Wed Sep 30 00:00:00 UTC 2020
Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.
Nature communications
Arasaki K,Mikami Y,Shames SR,Inoue H,Wakana Y,Tagaya M
A-6455 was used in Western Blotting to demonstrate cleavage of syntaxin 17 by Legionella pneumophila can shut down endoplasmic reticulum- mitochondria communication.
Mon May 15 00:00:00 UTC 2017
A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.
The Journal of biological chemistry
Bae N,Gao M,Li X,Premkumar T,Sbardella G,Chen J,Bedford MT
A-6455 was used in Chromatin immunoprecipitation to gain mechanistic insight into how SPIN1 functions as a transcriptional coactivator, purifying its interacting proteins.
Fri Dec 22 00:00:00 UTC 2017
A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria.
Scientific reports
Harmon M,Larkman P,Hardingham G,Jackson M,Skehel P
A-6455 was used in Immunocytochemistry to propose a novel bifluorescence complementation (BiFC) method for detecting endoplasmic reticulum-mitochondria associations.
Tue Dec 12 00:00:00 UTC 2017
Dissecting Kinase Effector Signaling Using the RapRTAP Methodology.
Methods in molecular biology (Clifton, N.J.)
Ray AM,Klomp JE,Collins KB,Karginov AV
A-6455 was used in ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot to present a new tool to selectively activate a kinase in a specific protein complex in living cells.
Wed Apr 11 00:00:00 UTC 2018
Motor control of Drosophila feeding behavior.
eLife
Schwarz O,Bohra AA,Liu X,Reichert H,VijayRaghavan K,Pielage J
A-6455 was used in Immunohistochemistry to support a model in which central command circuits recruit individual motoneurons to generate task-specific proboscis extension sequences.
Fri Feb 17 00:00:00 UTC 2017
Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity.
PloS one
Murthy S,Koval OM,Ramiro Diaz JM,Kumar S,Nuno D,Scott JA,Allamargot C,Zhu LJ,Broadhurst K,Santhana V,Kutschke WJ,Irani K,Lamping KG,Grumbach IM
A-6455 was used in Immunohistochemistry to demonstrate that CaMKII plays an important role in transient bradykinin-driven eNOS activation in vitro, but does not regulate NO production, vasorelaxation or blood pressure in vivo under baseline conditions.
Mon Nov 13 00:00:00 UTC 2017
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.
eLife
Bucks SA,Cox BC,Vlosich BA,Manning JP,Nguyen TB,Stone JS
A6455 was used in immunohistochemistry to establish that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions
Mon Mar 06 00:00:00 UTC 2017
Enforcement of developmental lineage specificity by transcription factor Oct1.
eLife
Shen Z,Kang J,Shakya A,Tabaka M,Jarboe EA,Regev A,Tantin D
A-6455 was used in Immunohistochemistry, Immunocytochemistry to study the role of Oct1 in ESC pluripotency and transcriptional control by constructing germline and inducible-conditional Oct1-deficient ESC lines.
Wed May 24 00:00:00 UTC 2017
Enforcement of developmental lineage specificity by transcription factor Oct1.
eLife
Shen Z,Kang J,Shakya A,Tabaka M,Jarboe EA,Regev A,Tantin D
A-6455 was used in Immunohistochemistry, Immunocytochemistry to study the role of Oct1 in ESC pluripotency and transcriptional control by constructing germline and inducible-conditional Oct1-deficient ESC lines.
Wed May 24 00:00:00 UTC 2017
Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe.
Nature communications
Richier B,Vijandi CM,Mackensen S,Salecker I
A-6455 was used in Immunohistochemistry-immunofluorescence to study the molecular cues controlling astrocyte branch morphogenesis and positioning during neural circuit assembly in the Drosophila optic lobe.
Tue Aug 22 00:00:00 UTC 2017
Functional mapping of brain synapses by the enriching activity-marker SynaptoZip.
Nature communications
Ferro M,Lamanna J,Ripamonti M,Racchetti G,Arena A,Spadini S,Montesano G,Cortese R,Zimarino V,Malgaroli A
A-6455 was used in Immunocytochemistry to show its broad applicability by reporting stimulus-evoked and spontaneous circuit activity in wide cortical fields, in anesthetized and freely moving animals.
Tue Oct 31 00:00:00 UTC 2017
Functional mapping of brain synapses by the enriching activity-marker SynaptoZip.
Nature communications
Ferro M,Lamanna J,Ripamonti M,Racchetti G,Arena A,Spadini S,Montesano G,Cortese R,Zimarino V,Malgaroli A
A-6455 was used in Immunocytochemistry to show its broad applicability by reporting stimulus-evoked and spontaneous circuit activity in wide cortical fields, in anesthetized and freely moving animals.
Tue Oct 31 00:00:00 UTC 2017
Myosin IIA Heavy Chain Phosphorylation Mediates Adhesion Maturation and Protrusion in Three Dimensions.
The Journal of biological chemistry
Rai V,Thomas DG,Beach JR,Egelhoff TT
A-6455 was used in Flow Cytometry to demonstrate a critical and previously unrecognized role for NMIIA phosphorylation in 3D invasion.
Fri Feb 24 00:00:00 UTC 2017
A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster.
G3 (Bethesda, Md.)
Anderson AM,Bailetti AA,Rodkin E,De A,Bach EA
A-6455 was used in Immunohistochemistry to support a model in which elevated Yki signaling increases the number of hemocytes, which become melanotic tumors as a result of elevated JAK/STAT signaling.
Mon Aug 07 00:00:00 UTC 2017
Mapping and Analysis of the Connectome of Sympathetic Premotor Neurons in the Rostral Ventrolateral Medulla of the Rat Using a Volumetric Brain Atlas.
Frontiers in neural circuits
Dempsey B,Le S,Turner A,Bokiniec P,Ramadas R,Bjaalie JG,Menuet C,Neve R,Allen AM,Goodchild AK,McMullan S
A-6455 was used in Immunohistochemistry to use a genetically restricted viral tracing strategy to definitively map their spatially diffuse connectome.
Mon Oct 23 00:00:00 UTC 2017
The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.
Biochimica et biophysica acta. Molecular cell research
Kristó I,Bajusz C,Borsos BN,Pankotai T,Dopie J,Jankovics F,Vartiainen MK,Erdélyi M,Vilmos P
A-6455 was used in Immunohistochemistry to illustrate that Moesin is a functional component of the nucleus and demonstrate that it plays role in mRNA export.
Sun Oct 01 00:00:00 UTC 2017
Helicase Domain of West Nile Virus NS3 Protein Plays a Role in Inhibition of Type I Interferon Signalling.
Viruses
Setoh YX,Periasamy P,Peng NYG,Amarilla AA,Slonchak A,Khromykh AA
A-6455 was used in Immunocytochemistry to show that the inhibition of type I interferon signalling was independent of other known functions of NS3 in RNA replication and assembly of virus particles.
Thu Nov 02 00:00:00 UTC 2017
CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster.
G3 (Bethesda, Md.)
Pathak T,Trivedi D,Hasan G
A-6455 was used in Immunohistochemistry to determine the role of the endoplasmic reticulum calcium sensor STIM in larval dopaminergic cells.
Fri Mar 10 00:00:00 UTC 2017
Autophagy maintains stemness by preventing senescence.
Nature
García-Prat L,Martínez-Vicente M,Perdiguero E,Ortet L,Rodríguez-Ubreva J,Rebollo E,Ruiz-Bonilla V,Gutarra S,Ballestar E,Serrano AL,Sandri M,Muñoz-Cánoves P
A-6455 was used in immunohistochemistry to study the importance of basal autophagy in the maintenance of the stem-cell quiescent state
Thu Jan 07 00:00:00 UTC 2016
Genetically targeted magnetic control of the nervous system.
Nature neuroscience
Wheeler MA,Smith CJ,Ottolini M,Barker BS,Purohit AM,Grippo RM,Gaykema RP,Spano AJ,Beenhakker MP,Kucenas S,Patel MK,Deppmann CD,Güler AD
A-6455 was used in immunohistochemistry to study magnetic control that is genetically targeted in the nervous system
Sun May 01 00:00:00 UTC 2016
A viral strategy for targeting and manipulating interneurons across vertebrate species.
Nature neuroscience
Dimidschstein J,Chen Q,Tremblay R,Rogers SL,Saldi GA,Guo L,Xu Q,Liu R,Lu C,Chu J,Grimley JS,Krostag AR,Kaykas A,Avery MC,Rashid MS,Baek M,Jacob AL,Smith GB,Wilson DE,Kosche G,Kruglikov I,Rusielewicz T,Kotak VC,Mowery TM,Anderson SA,Callaway EM,Dasen JS,Fitzpatrick D,Fossati V,Long MA,Noggle S,Reynolds JH,Sanes DH,Rudy B,Feng G,Fishell G
A6455 was used in immunocytochemistry to develop a recombinant adeno-associated virus that restricts gene expression to GABAergic interneurons within the telencephalon
Thu Dec 01 00:00:00 UTC 2016
The actin cable is dispensable in directing dorsal closure dynamics but neutralizes mechanical stress to prevent scarring in the Drosophila embryo.
Nature cell biology
Ducuing A,Vincent S
A6455 was used in immunohistochemistry to determine the function of the actin cable using Drosophila dorsal closure
Tue Nov 01 00:00:00 UTC 2016
Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila.
Current biology : CB
Rohwedder A,Wenz NL,Stehle B,Huser A,Yamagata N,Zlatic M,Truman JW,Tanimoto H,Saumweber T,Gerber B,Thum AS
A-6455 was used in immunohistochemistry to determine the function of different dopaminergic neurons using larval Drosophila
Mon Mar 07 00:00:00 UTC 2016
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
The Journal of cell biology
McLelland GL,Lee SA,McBride HM,Fon EA
A6455 was used in western blot to show that syntaxin-17 is required for the delivery of stress-induced PINK1/parkin-dependent mitochondrial-derived vesicles to the late endosome/lysosome
Mon Aug 01 00:00:00 UTC 2016
Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
Development (Cambridge, England)
Cate MS,Gajendra S,Alsbury S,Raabe T,Tear G,Mitchell KJ
A-6455 was used in immunohistochemistry to assess the requirement for Netrin and a mushroom body defect in parallel for midline axon guidance in Drosophila
Tue Mar 15 00:00:00 UTC 2016
Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Brown RS,Kokay IC,Phillipps HR,Yip SH,Gustafson P,Wyatt A,Larsen CM,Knowles P,Ladyman SR,LeTissier P,Grattan DR
A-6455 was used in immunohistochemistry to test if GABA is involved in feedback regulation of tuberoinfundibular dopamine neurons
Wed Aug 31 00:00:00 UTC 2016
NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma.
Journal of virology
Verhoeven RJ,Tong S,Zhang G,Zong J,Chen Y,Jin DY,Chen MR,Pan J,Chen H
A-6455 was used in immunoprecipitation to determine regulation of expression of Epstein-Barr virus BART microRNAs and long noncoding RNAs in nasopharyngeal carcinoma via NF-kappaB signaling
Fri Jul 15 00:00:00 UTC 2016
Phosphorylation Requirement of Murine Leukemia Virus p12.
Journal of virology
Brzezinski JD,Felkner R,Modi A,Liu M,Roth MJ
A-6455 was used in Immunoprecipitation to indicate that the N terminus of p12 represses the early function of the chromatin binding domain and that deletion of the N terminus activates chromatin binding in the wild-type Moloney MLV p12 protein.
Thu Dec 15 00:00:00 UTC 2016
Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.
The Journal of physiology
Ferrari LL,Agostinelli LJ,Krashes MJ,Lowell BB,Scammell TE,Arrigoni E
A6455 was used in immunohistochemistry to determine the effect of dynorphin on basal forebrain cholinergic neurons
Mon Feb 15 00:00:00 UTC 2016
Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of Bone Marrow CD45 Cells Over Mesenchymal Stem Cells in Liver Cirrhosis.
Stem cells (Dayton, Ohio)
Baligar P,Mukherjee S,Kochat V,Rastogi A,Mukhopadhyay A
A-6455 was used in western blot to test if bone marrow-derived CD45 cells are better than mesenchymal stem cells to treat fibrosis
Fri Jan 01 00:00:00 UTC 2016
The Role of Hypothalamic NF-κB Signaling in the Response of the HPT-Axis to Acute Inflammation in Female Mice.
Endocrinology
de Vries EM,Nagel S,Haenold R,Sundaram SM,Pfrieger FW,Fliers E,Heuer H,Boelen A
A-6455 was used in immunohistochemistry to study acute inflammation in female mice by the role of hypothalamic NF-kappaB signaling in the response of the HPT-axis
Fri Jul 01 00:00:00 UTC 2016
Long-Term Protection of Retinal Ganglion Cells and Visual Function by Brain-Derived Neurotrophic Factor in Mice With Ocular Hypertension.
Investigative ophthalmology & visual science
Feng L,Chen H,Yi J,Troy JB,Zhang HF,Liu X
A-6455 was used in immunohistochemistry to test if BDNF exerts long-term protection of retinal ganglion cell subtypes and vision against chronic elevated intraocular pressure
Fri Jul 01 00:00:00 UTC 2016
Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus.
Neuroscience
Erbs E,Faget L,Ceredig RA,Matifas A,Vonesch JL,Kieffer BL,Massotte D
A-6455 was used in immunohistochemistry (frozen) to assess the impact of repeated drug exposure on hippocampal delta receptors.
Thu Jan 28 00:00:00 UTC 2016
Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice.
Neuroscience
Morrison HW,Filosa JA
A-6455 was used in immunohistochemistry to investigate sex differences in glial physiology that contribute to stroke pathobiology
Sat Dec 17 00:00:00 UTC 2016
Rapid induction of GFP expression by the nitrate reductase promoter in the diatom Phaeodactylum tricornutum.
PeerJ
Chu L,Ewe D,Río Bártulos C,Kroth PG,Gruber A
A-6455 was used in western blot examine the time-dependent expression of the green fluorescent protein under control of the nitrate reductase promoter in several Phaeodactylum tricornutum cell lines
Fri Sep 16 00:00:00 UTC 2016
Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.
The EMBO journal
Vingill S,Brockelt D,Lancelin C,Tatenhorst L,Dontcheva G,Preisinger C,Schwedhelm-Domeyer N,Joseph S,Mitkovski M,Goebbels S,Nave KA,Schulz JB,Marquardt T,Lingor P,Stegmüller J
A-6455 was used in Immunocytochemistry to establish a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function.
Thu Sep 15 00:00:00 UTC 2016
RGMB and neogenin control cell differentiation in the developing olfactory epithelium.
Development (Cambridge, England)
Kam JW,Dumontier E,Baim C,Brignall AC,Mendes da Silva D,Cowan M,Kennedy TE,Cloutier JF
A-6455 was used in Immunohistochemistry to indicate that RGMB-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the OE.
Sun May 01 00:00:00 UTC 2016
Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification.
Scientific reports
Liu L,Liu X,Ren X,Tian Y,Chen Z,Xu X,Du Y,Jiang C,Fang Y,Liu Z,Fan B,Zhang Q,Jin G,Yang X,Zhang X
A-6455 was used in immunocytochemistry and western blot to elucidate the contributions of Smad2 and Smad3 to TGFbeta signaling
Wed Feb 24 00:00:00 UTC 2016
Calcineurin Subunits A and B Interact to Regulate Growth and Asexual and Sexual Development in Neurospora crassa.
PloS one
Tamuli R,Deka R,Borkovich KA
A-6455 was used in western blot to examine the potential interaction between CNA-1 and CNB-1 proteins
Fri Aug 05 00:00:00 UTC 2016
A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism.
Nature communications
Gomez-Diaz C,Bargeton B,Abuin L,Bukar N,Reina JH,Bartoi T,Graf M,Ong H,Ulbrich MH,Masson JF,Benton R
A-6455 was used in immunocytochemistry and immunohistochemistry - frozen section to study mediation of insect pheromone detection via a putative tunnelling mechanism by a CD36 ectodomain
Wed Jun 15 00:00:00 UTC 2016
Dynamic association of calcium channel subunits at the cellular membrane.
Neurophotonics
Voigt A,Freund R,Heck J,Missler M,Obermair GJ,Thomas U,Heine M
A-6455 was used in Immunocytochemistry to propose that their dynamic assembly and disassembly represent an important mechanism to regulate the signaling properties of VGCC.
Sat Oct 01 00:00:00 UTC 2016
Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation.
Oncotarget
Carrasco-Ramírez P,Greening DW,Andrés G,Gopal SK,Martín-Villar E,Renart J,Simpson RJ,Quintanilla M
A-6455 was used in immunocytochemistry to study a component of extracellular vesicles, podoplanin, that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation
Tue Mar 29 00:00:00 UTC 2016
Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
Nature
Liu BH,Huberman AD,Scanziani M
A-6455 was used in Immunohistochemistry to show that projections from the mouse visual cortex to the accessory optic system promote the adaptive plasticity of the OKR.
Thu Oct 20 00:00:00 UTC 2016
Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca(2+) signalling in glutamatergic interneurons.
eLife
Jayakumar S,Richhariya S,Reddy OV,Texada MJ,Hasan G
A-6455 was used in immunohistochemistry study a neuronal circuit that promotes Drosophila larvae survival during amino acid deprivation
Fri Aug 05 00:00:00 UTC 2016
Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts.
Development (Cambridge, England)
Zhang F,Huang ZX,Bao H,Cong F,Wang H,Chai PC,Xi Y,Ge W,Somers WG,Yang Y,Cai Y,Yang X
A-6455 was used in Immunocytochemistry to reveal that cortical association of Mira mediated by the PTPA-PP4 complex is followed by apical aPKC-mediated basal restriction.
Fri Jan 01 00:00:00 UTC 2016
A dual molecular analogue tuner for dissecting protein function in mammalian cells.
Nature communications
Brosh R,Hrynyk I,Shen J,Waghray A,Zheng N,Lemischka IR
A-6455 was used in Western Blot to demonstrate a molecular system for determining mammalian protein functions.
Fri May 27 00:00:00 UTC 2016
Cross-hemispheric dopamine projections have functional significance.
Proceedings of the National Academy of Sciences of the United States of America
Fox ME,Mikhailova MA,Bass CE,Takmakov P,Gainetdinov RR,Budygin EA,Wightman RM
A-6455 was used in Immunohistochemistry-immunofluorescence to reveal that psychostimulants, such as amphetamine, promote the coupling of dopamine transients between hemispheres.
Tue Jun 21 00:00:00 UTC 2016
Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress.
The Biochemical journal
Droubi A,Bulley SJ,Clarke JH,Irvine RF
A-6455 was used in Immunoprecipitation to explore the phenotype of PI5P4K B-null cells exposed to nutrient deprivation and find that they can sustain a greater degree of nutrient deprivation than their wild-type counterparts possibly as a result of up-regulation of autophagy.
Fri Jul 15 00:00:00 UTC 2016
Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors.
Neuroscience
Mikhailova MA,Bass CE,Grinevich VP,Chappell AM,Deal AL,Bonin KD,Weiner JL,Gainetdinov RR,Budygin EA
A-6455 was used in Immunohistochemistry to demonstrate that tonic optogenetic stimulation of VTA-nucleus accumbens dopamine release is sufficient to inhibit reward consummatory behavior, possibly by preventing this circuit from engaging in phasic activity that is thought to be essential for reward-based behaviors.
Sat Oct 01 00:00:00 UTC 2016
Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform.
Open biology
Tzani I,Ivanov IP,Andreev DE,Dmitriev RI,Dean KA,Baranov PV,Atkins JF,Loughran G
A-6455 was used in western blot identify and characterize two non-AUG-initiated PTEN proteoforms
Sun May 01 00:00:00 UTC 2016
Mechanosensory interactions drive collective behaviour in Drosophila.
Nature
Ramdya P,Lichocki P,Cruchet S,Frisch L,Tse W,Floreano D,Benton R
A-6455 was used in immunohistochemistry to demonstrate that Drosophila melanogaster exhibits collective responses to an aversive odor
Thu Mar 12 00:00:00 UTC 2015
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
Nature
Mertens J,Wang QW,Kim Y,Yu DX,Pham S,Yang B,Zheng Y,Diffenderfer KE,Zhang J,Soltani S,Eames T,Schafer ST,Boyer L,Marchetto MC,Nurnberger JI,Calabrese JR,Ødegaard KJ,McCarthy MJ,Zandi PP,Alda M,Nievergelt CM,Mi S,Brennand KJ,Kelsoe JR,Gage FH,Yao J
A-6455 was used in Immunocytochemistry-immunoflourescence to show extracellular matrix stiffness regulates endothelial barrier function by a mechanism using focal adhesion kinase activity.
Thu Nov 05 00:00:00 UTC 2015
Cell type-specific manipulation with GFP-dependent Cre recombinase.
Nature neuroscience
Tang JC,Rudolph S,Dhande OS,Abraira VE,Choi S,Lapan SW,Drew IR,Drokhlyansky E,Huberman AD,Regehr WG,Cepko CL
A-6455 was used in immunohistochemistry to study GFP-dependent Cre recombinase by cell type-specific manipulation
Tue Sep 01 00:00:00 UTC 2015
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Nature cell biology
Priya R,Gomez GA,Budnar S,Verma S,Cox HL,Hamilton NA,Yap AS
A-6455 was used in immunocytochemistry to identify factors that regulate the stability of the RhoA zone
Thu Oct 01 00:00:00 UTC 2015
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
EMBO molecular medicine
Ito H,Fujita K,Tagawa K,Chen X,Homma H,Sasabe T,Shimizu J,Shimizu S,Tamura T,Muramatsu S,Okazawa H
A-6455 was used in immunohistochemistry - paraffin section to study the extension of lifespan of mutant ataxin-1 knock-in mice due to HMGB1 facilitated repair of mitochondrial DNA damage
Thu Jan 01 00:00:00 UTC 2015
spenito is required for sex determination in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
Yan D,Perrimon N
A-6455 was used in immunocytochemistry and western blot to identify and characterize a new sex determination gene, spenito.
Tue Sep 15 00:00:00 UTC 2015
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
The Journal of cell biology
Thomas DG,Yenepalli A,Denais CM,Rape A,Beach JR,Wang YL,Schiemann WP,Baskaran H,Lammerding J,Egelhoff TT
A-6455 was used in immunohistochemistry and western blot to determine how nuclear translocation during 3D invasion requires non-muscle myosin IIB
Mon Aug 17 00:00:00 UTC 2015
L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.
The Journal of cell biology
Siegenthaler D,Enneking EM,Moreno E,Pielage J
A-6455 was used in immunohistochemistry to identify cell adhesion molecule-mediated axon-axon interactions that enable assembly of neuronal circuits.
Mon Mar 30 00:00:00 UTC 2015
The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.
Development (Cambridge, England)
Sherrard KM,Fehon RG
A-6455 was used in immunohistochemistry to elucidate the role of Crumbs in epithelial morphogenesis.
Fri May 15 00:00:00 UTC 2015
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Moyon S,Dubessy AL,Aigrot MS,Trotter M,Huang JK,Dauphinot L,Potier MC,Kerninon C,Melik Parsadaniantz S,Franklin RJ,Lubetzki C
A-6455 was used in Immunofluorescence in immunohistochemistry on frozen tissues to invesitgate how oligodendrocyte progenitor cells become activated after demyelination and how this enables them to contribute to remyelination.
Wed Jan 07 00:00:00 UTC 2015
Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neupert C,Schneider R,Klatt O,Reissner C,Repetto D,Biermann B,Niesmann K,Missler M,Heine M
A-6455 was used in immunocytochemistry to study the dynamics and regulation of neurexin trafficking.
Wed Oct 07 00:00:00 UTC 2015
Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types.
The Journal of neuroscience : the official journal of the Society for Neuroscience
El-Danaf RN,Huberman AD
A-6455 was used in immunohistochemistry to determine the type and timing of cellular changes leading to retinal ganglion cell loss in glaucoma.
Wed Feb 11 00:00:00 UTC 2015
Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pooryasin A,Fiala A
A-6455 was used in immunohistochemistry - free floating to study factors that regulate arousal negatively and induce states of quiescence using Drosophila
Wed Sep 16 00:00:00 UTC 2015
Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pathak T,Agrawal T,Richhariya S,Sadaf S,Hasan G
A-6455 was used in immunohistochemistry to report that Orai-mediated store operated calcium entry is required in dopaminergic interneurons of the flight circuit during pupal development.
Wed Oct 07 00:00:00 UTC 2015
Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Miao Q,Yuan J,Han S,Zhang P,Li S,Rao Z,Zhao W,Ye Q,Geng J,Zhang X,Cheng L
A-6455 was used in Immunocytochemistry to show that expression of achaete-scute complex homolog-like 1 alone is sufficient to convert dorsal midbrain astrocytes of mice into functional induced neuronal cells in vitro and vivo.
Wed Jun 24 00:00:00 UTC 2015
Molecular dissection of Phaseolus vulgaris polygalacturonase-inhibiting protein 2 reveals the presence of hold/release domains affecting protein trafficking toward the cell wall.
Frontiers in plant science
De Caroli M,Lenucci MS,Manualdi F,Dalessandro G,De Lorenzo G,Piro G
A-6455 was used in immunocytochemistry and western blot to elucidate mechanisms that mediate trafficking toward the apoplast.
Fri Sep 18 00:00:00 UTC 2015
Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Journal of virology
Nakahara T,Tanaka K,Ohno S,Egawa N,Yugawa T,Kiyono T
A-6455 was used in western blot to examine the role of NF-kappaB during the human papillomavirus life cycle
Fri May 01 00:00:00 UTC 2015
A retrograde adeno-associated virus for collecting ribosome-bound mRNA from anatomically defined projection neurons.
Frontiers in molecular neuroscience
Cook-Snyder DR,Jones A,Reijmers LG
A-6455 was used in Immunohistochemistry to obtain the gene expression profiles of projection neurons that are anatomically defined by the location of their soma and axon terminals.
Wed Nov 11 00:00:00 UTC 2015
Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant.
International journal of molecular medicine
Jang BY,Ryoo HD,Son J,Choi KC,Shin DM,Kang SW,Kang MJ
A-6455 was used in Western Blotting to demonstrate a role for the two Drosophila EDEMs in the degradation of alpha-1-antitrypsin (A1AT) variants, and establish a model for the study of A1AT deficiency in Drosophila.
Wed Apr 01 00:00:00 UTC 2015
Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor.
American journal of physiology. Cell physiology
Matsuoka H,Inoue M
A-6455 was used in immunocytochemistry to investigate the molecular mechanisms involved in TASK1 internalization in PC12 cells.
Sat Aug 15 00:00:00 UTC 2015
Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn.
Journal of cell science
Aittaleb M,Chen PJ,Akaaboune M
A-6455 was used in western blot to show that rapsyn plays an AChR-independent role in lysosomes organization.
Thu Oct 15 00:00:00 UTC 2015
Morphological Characterization of the Action Potential Initiation Segment in GnRH Neuron Dendrites and Axons of Male Mice.
Endocrinology
Herde MK,Herbison AE
A-6455 was used in immunohistochemistry to determine the location of action potential initiation in GnRH neurons.
Sun Nov 01 00:00:00 UTC 2015
The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase.
The Biochemical journal
Onyenwoke RU,Sexton JZ,Yan F,Díaz MC,Forsberg LJ,Major MB,Brenman JE
A-6455 was used in western blot to propose a mechanism for how TOR activity regulates the TRPML1 channel.
Tue Sep 15 00:00:00 UTC 2015
A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.
Brain structure & function
Erbs E,Faget L,Scherrer G,Matifas A,Filliol D,Vonesch JL,Koch M,Kessler P,Hentsch D,Birling MC,Koutsourakis M,Vasseur L,Veinante P,Kieffer BL,Massotte D
A-6455 was used in immunohistochemistry and immunoprecipitation to analyze neuronal co-occurrence in subcortical networks through a mu-delta opioid receptor brain atlas
Sun Mar 01 00:00:00 UTC 2015
Acute inhibition of a cortical motor area impairs vocal control in singing zebra finches.
The European journal of neuroscience
Yazaki-Sugiyama Y,Yanagihara S,Fuller PM,Lazarus M
A-6455 was used in immunohistochemistry to test if the ensembles of neurons in the robust nucleus of the arcopallium control the acoustic structure of specific song parts, but not the timing nor the order of song elements
Thu Jan 01 00:00:00 UTC 2015
Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals.
Frontiers in behavioral neuroscience
Gompf HS,Budygin EA,Fuller PM,Bass CE
A-6455 was used in immunohistochemistry (frozen) to develop a vector to induce neuron subtype specific gene expression in wildtype animals.
Mon Jul 20 00:00:00 UTC 2015
Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes.
Developmental neurobiology
Vergaño-Vera E,Díaz-Guerra E,Rodríguez-Traver E,Méndez-Gómez HR,Solís Ó,Pignatelli J,Pickel J,Lee SH,Moratalla R,Vicario-Abejón C
A-6455 was used in immunocytochemistry to investigate their role Nurr1 in the generation of dopaminergic neurons
Sat Aug 01 00:00:00 UTC 2015
Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.
The Journal of comparative neurology
Rohwedder A,Selcho M,Chassot B,Thum AS
A-6455 was used in immunohistochemistry to test if Drosophila neuropeptide F neurons are involved in classical olfactory conditioning
Tue Dec 15 00:00:00 UTC 2015
Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance.
Journal of molecular neuroscience : MN
Leyk J,Goldbaum O,Noack M,Richter-Landsberg C
A-6455 was used in western blot to investigate the role of HDAC6 in protein aggregate formation in oligodendrocytes
Wed Apr 01 00:00:00 UTC 2015
Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo.
PloS one
Kokkinopoulos I,Ishida H,Saba R,Ruchaya P,Cabrera C,Struebig M,Barnes M,Terry A,Kaneko M,Shintani Y,Coppen S,Shiratori H,Ameen T,Mein C,Hamada H,Suzuki K,Yashiro K
A-6455 was used in immunohistochemistry to characterize cardiac progenitor/precursor cells.
Wed Jul 06 00:00:00 UTC 2016
Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes.
Physiological research
Prukova D,Ileninova Z,Antosova B,Kasparek P,Gregor M,Sedlacek R
A-6455 was used in Immunohistochemistry-immunofluorescence to show that the Lecithin:retinol acyltransferase (LRAT) regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs.
Tue Apr 19 00:00:00 UTC 2016
Quantification of Protein Levels in Single Living Cells.
Cell reports
Lo CA,Kays I,Emran F,Lin TJ,Cvetkovska V,Chen BE
A-6455 was used in Immunofluorescence to develop a technique allowing for the in vivo quantification of proteins levels in single cells.
Tue Dec 22 00:00:00 UTC 2015
Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.
Development (Cambridge, England)
Ray A,Singh PN,Sohaskey ML,Harland RM,Bandyopadhyay A
A-6455 was used in Immunohistochemistry to identify the signalling molecules required for articular cartilage differentiation.
Sun Mar 15 00:00:00 UTC 2015
drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus.
Hippocampus
Puighermanal E,Biever A,Espallergues J,Gangarossa G,De Bundel D,Valjent E
A-6455 was used in Immunocytochemistry-immunofluorescence to suggest that in addition to the glutamatergic hilar mossy cells, D2R-expressing cells constitute a subpopulation of GABAergic hippocampal interneurons.
Wed Jul 01 00:00:00 UTC 2015
Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.
Cardiovascular research
Shen H,Cavallero S,Estrada KD,Sandovici I,Kumar SR,Makita T,Lien CL,Constancia M,Sucov HM
A-6455 was used in Immunohistochemistry to demonstrate that ventricular wall cardiomyocyte proliferation is subdivided into distinct regulatory phases.
Sun Mar 01 00:00:00 UTC 2015
Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis.
Nature communications
Arbeille E,Reynaud F,Sanyas I,Bozon M,Kindbeiter K,Causeret F,Pierani A,Falk J,Moret F,Castellani V
A-6455 was used in immunohistochemistry to test if extracellular signals orient the mitotic spindle of cells in the spinal cord.
Fri Feb 27 00:00:00 UTC 2015
Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.
Nature communications
Pearce MMP,Spartz EJ,Hong W,Luo L,Kopito RR
A-6455 was used in Immunohistochemistry to suggest a potential mechanism by which phagocytic glia contribute to both protein aggregate-related neuroprotection and pathogenesis in neurodegenerative disease.
Mon Apr 13 00:00:00 UTC 2015
A chimeric embryoid body model to study vascular morphogenesis.
Methods in molecular biology (Clifton, N.J.)
Qi Y,Saadat S,Liu J,Graham AM,Li S
A-6455 was used in Immunohistochemistry-immunofluorescence to describe a chimeric EB vessel development model, in which the utilization of the PECAM-GFP reporter gene in wild-type ESCs allows for the introduction of normal" extracellular factors formed by its parallel differentiation to the gene-deletion EC that might otherwise be devoid of these factors."
Tue Jul 14 00:00:00 UTC 2015
A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.
Nature communications
Fulga TA,McNeill EM,Binari R,Yelick J,Blanche A,Booker M,Steinkraus BR,Schnall-Levin M,Zhao Y,DeLuca T,Bejarano F,Han Z,Lai EC,Wall DP,Perrimon N,Van Vactor D
A-6455 was used in Immunohistochemistry to offer a comprehensive library of 141 conditional miRNA sponges targeting well-conserved miRNAs in Drosophila.
Wed Jun 17 00:00:00 UTC 2015
Proteome response at the edge of protein aggregation.
Open biology
Sanchez de Groot N,Gomes RA,Villar-Pique A,Babu MM,Coelho AV,Ventura S
A-6455 was used in western blot to elucidate the edge of protein aggregation and the proteome response
Sun Feb 01 00:00:00 UTC 2015
Pea3 determines the isthmus region at the downstream of Fgf8-Ras-ERK signaling pathway.
Development, growth & differentiation
Harada H,Omi M,Sato T,Nakamura H
A-6455 was used in Immunohistochemistry to determine metencephalon.
Tue Dec 01 00:00:00 UTC 2015
Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells.
The Journal of biological chemistry
Jevtić P,Edens LJ,Li X,Nguyen T,Chen P,Levy DL
A-6455 was used in immunohistochemistry and western blot to investigate how lamins regulate the size of the nucleus.
Fri Nov 13 00:00:00 UTC 2015
Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling.
Journal of visualized experiments : JoVE
Berens C,Bisle S,Klingenbeck L,Lührmann A
A-6455 was used in western blot to study CaeB-mediated apoptosis.
Thu Jun 25 00:00:00 UTC 2015
Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging.
Cell metabolism
Baris OR,Ederer S,Neuhaus JF,von Kleist-Retzow JC,Wunderlich CM,Pal M,Wunderlich FT,Peeva V,Zsurka G,Kunz WS,Hickethier T,Bunck AC,Stöckigt F,Schrickel JW,Wiesner RJ
A-6455 was used in Immunohistochemistry to suggest that the disposition to arrhythmia typically found in the aged human heart might be due to the random accumulation of mtDNA deletions and the subsequent mosaic respiratory chain deficiency.
Tue May 05 00:00:00 UTC 2015
Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.
Nature communications
Iacovella MG,Golfieri C,Massari LF,Busnelli S,Pagliuca C,Dal Maschio M,Infantino V,Visintin R,Mechtler K,Ferreira-Cerca S,De Wulf P
A-6455 was used in immunocytochemistry to show that nuclear Rio1 integrates rDNA replication and segregation with ribosome biogenesis.
Wed Apr 08 00:00:00 UTC 2015
Recording, labeling, and transfection of single neurons in deep brain structures.
Physiological reports
Dempsey B,Turner AJ,Le S,Sun QJ,Bou Farah L,Allen AM,Goodchild AK,McMullan S
A-6455 was used in immunohistochemistry to describe a method to deliver conventional dyes or genetic material in vitro and in vivo to neurons
Thu Jan 01 00:00:00 UTC 2015
Geriatric muscle stem cells switch reversible quiescence into senescence.
Nature
Sousa-Victor P,Gutarra S,García-Prat L,Rodriguez-Ubreva J,Ortet L,Ruiz-Bonilla V,Jardí M,Ballestar E,González S,Serrano AL,Perdiguero E,Muñoz-Cánoves P
A-6455 was used in immunohistochemistry (frozen) to show that geriatric satellite cells do not maintain their normal quiescent state in muscle homeostatic conditions and that this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Thu Feb 20 00:00:00 UTC 2014
Genome-defence small RNAs exapted for epigenetic mating-type inheritance.
Nature
Singh DP,Saudemont B,Guglielmi G,Arnaiz O,Goût JF,Prajer M,Potekhin A,Przybòs E,Aubusson-Fleury A,Bhullar S,Bouhouche K,Lhuillier-Akakpo M,Tanty V,Blugeon C,Alberti A,Labadie K,Aury JM,Sperling L,Duharcourt S,Meyer E
A-6455 was used in immunocytochemistry to study maternal inheritance of mating types in Paramecium tetraurelia.
Thu May 22 00:00:00 UTC 2014
Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human.
Nature neuroscience
Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chelly J,Croquelois A,Francis F
A-6455 was used in immunocytochemistry and immunohistochemistry - frozen section to investigate the relationships among abnormal spindle orientations, ectopic progenitors, and severe heterotopia in mouse and human.
Tue Jul 01 00:00:00 UTC 2014
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW
A-6455 was used in western blot to study the effect of panobinostat treatment on disease using an acute myeloid leukemia mouse model.
Thu Feb 27 00:00:00 UTC 2014
A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator.
Nucleic acids research
Di Lorenzo A,Yang Y,Macaluso M,Bedford MT
A-6455 was used in immunoprecipitation to study the biological role of protein arginine methyltransferase 6 in transgenic mice.
Tue Jul 01 00:00:00 UTC 2014
Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function.
The EMBO journal
Cuartero S,Fresán U,Reina O,Planet E,Espinàs ML
A-6455 was used in western blot to identify novel pathway of CP190 chromatin recruitment.
Tue Mar 18 00:00:00 UTC 2014
Dimerization of mammalian kinesin-3 motors results in superprocessive motion.
Proceedings of the National Academy of Sciences of the United States of America
Soppina V,Norris SR,Dizaji AS,Kortus M,Veatch S,Peckham M,Verhey KJ
A-6455 was used in immunocytochemistry to show that KIF16B motors undergo cargo-mediated dimerization
Tue Apr 15 00:00:00 UTC 2014
Compartmentalized cyanophycin metabolism in the diazotrophic filaments of a heterocyst-forming cyanobacterium.
Proceedings of the National Academy of Sciences of the United States of America
Burnat M,Herrero A,Flores E
A-6455 was used in western blot to identify beta-aspartyl-arginine as a nitrogen vehicle of heterocyst-forming cyanobacteria
Tue Mar 11 00:00:00 UTC 2014
A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus.
Journal of controlled release : official journal of the Controlled Release Society
José A,Rovira-Rigau M,Luna J,Giménez-Alejandre M,Vaquero E,García de la Torre B,Andreu D,Alemany R,Fillat C
A-6455 was used in immunohistochemistry - paraffin section to study MMP-activatable adenovirus as a treatment for pancreatic cancer.
Tue Oct 28 00:00:00 UTC 2014
Mutations of CEP83 cause infantile nephronophthisis and intellectual disability.
American journal of human genetics
Failler M,Gee HY,Krug P,Joo K,Halbritter J,Belkacem L,Filhol E,Porath JD,Braun DA,Schueler M,Frigo A,Alibeu O,Masson C,Brochard K,Hurault de Ligny B,Novo R,Pietrement C,Kayserili H,Salomon R,Gubler MC,Otto EA,Antignac C,Kim J,Benmerah A,Hildebrandt F,Saunier S
A-6455 was used in western blot to identify distal appendages components defective in ciliopathies.
Thu Jun 05 00:00:00 UTC 2014
ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth.
Oncogene
Moreno A,Soleto I,García-Sanz P,Moreno-Bueno G,Palmero I
A-6455 was used in immunohistochemistry - paraffin section to investigate the function of ING4 in normal, non-transformed primary fibroblasts.
Thu Apr 10 00:00:00 UTC 2014
Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2.
The Journal of cell biology
Bulat V,Rast M,Pielage J
A-6455 was used in immunohistochemistry and western blot to report that casein kinase 2 is essential for synapse maintenance
Mon Jan 06 00:00:00 UTC 2014
Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Development (Cambridge, England)
Nishimura YV,Shikanai M,Hoshino M,Ohshima T,Nabeshima Y,Mizutani K,Nagata K,Nakajima K,Kawauchi T
A-6455 was used in western blot to elucidate the molecular mechanisms of dilation formation and nuclear elongation
Mon Sep 01 00:00:00 UTC 2014
The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.
Development (Cambridge, England)
Rogulja-Ortmann A,Picao-Osorio J,Villava C,Patraquim P,Lafuente E,Aspden J,Thomsen S,Technau GM,Alonso CR
A-6455 was used in immunohistochemistry to explore how RNA processing regulates Hox genes and development of the central nervous system.
Thu May 01 00:00:00 UTC 2014
Proteomic profiling of cardiac tissue by isolation of nuclei tagged in specific cell types (INTACT).
Development (Cambridge, England)
Amin NM,Greco TM,Kuchenbrod LM,Rigney MM,Chung MI,Wallingford JB,Cristea IM,Conlon FL
A-6455 was used in immunohistochemistry - frozen section to describe a method for the purification of nuclei from defined cell or tissue types in vertebrate embryos.
Sat Feb 01 00:00:00 UTC 2014
The role of T-cadherin in axonal pathway formation in neocortical circuits.
Development (Cambridge, England)
Hayano Y,Zhao H,Kobayashi H,Takeuchi K,Norioka S,Yamamoto N
A-6455 was used in immunohistochemistry to investigate the mechanism of axonal pathway formation in rat cortical axons
Mon Dec 01 00:00:00 UTC 2014
Specification of neuronal subtypes by different levels of Hunchback.
Development (Cambridge, England)
Moris-Sanz M,Estacio-Gómez A,Alvarez-Rivero J,Díaz-Benjumea FJ
A-6455 was used in immunohistochemistry to study the effect of Hunchback expression in two different Crustacean cardioactive peptide neuronal fates
Sat Nov 01 00:00:00 UTC 2014
EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.
Development (Cambridge, England)
Steinecke A,Gampe C,Zimmer G,Rudolph J,Bolz J
A-6455 was used in Immunohistochemistry to describe a novel role of the ephrins in driving these neurons to their target via reverse signaling.
Wed Jan 01 00:00:00 UTC 2014
A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis.
Development (Cambridge, England)
Dubaissi E,Rousseau K,Lea R,Soto X,Nardeosingh S,Schweickert A,Amaya E,Thornton DJ,Papalopulu N
A-6455 was used in immunohistochemistry to study the frog embryonic mucocilliary epidermis and how a protective, anti-infective function after secretory cell types develop alongside ionocytes, goblet cells, and multicilliated cells
Tue Apr 01 00:00:00 UTC 2014
Transit amplification in the amniote cerebellum evolved via a heterochronic shift in NeuroD1 expression.
Development (Cambridge, England)
Butts T,Hanzel M,Wingate RJ
A-6455 was used in immunohistochemistry to examine the molecular geography of cerebellar development throughout the life cycle of Xenopus laevis
Tue Jul 01 00:00:00 UTC 2014
Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao ZQ,Wan L,Liu XY,Huo FQ,Li H,Barry DM,Krieger S,Kim S,Liu ZC,Xu J,Rogers BE,Li YQ,Chen ZF
A-6455 was used in immunohistochemistry - free floating and western blot to investigate the role of Nmbr and Grpr in itching
Wed Sep 10 00:00:00 UTC 2014
TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.
Human molecular genetics
Ngo L,Haas M,Qu Z,Li SS,Zenker J,Teng KS,Gunnersen JM,Breuss M,Habgood M,Keays DA,Heng JI
A-6455 was used in immunohistochemistry - frozen section to study the role of TUBB5 in neuronal differentiation and connectivity.
Wed Oct 01 00:00:00 UTC 2014
Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.
Human molecular genetics
Vincent SD,Mayeuf-Louchart A,Watanabe Y,Brzezinski JA,Miyagawa-Tomita S,Kelly RG,Buckingham M
A-6455 was used in immunohistochemistry (frozen) to identify PRDM1 as a mediator of phenotypic severity in TBX1 haploinsufficient DiGeorge syndrome patients.
Wed Oct 01 00:00:00 UTC 2014
Inactivation of agmatinase expressed in vegetative cells alters arginine catabolism and prevents diazotrophic growth in the heterocyst-forming cyanobacterium Anabaena.
MicrobiologyOpen
Burnat M,Flores E
A-6455 was used in western blot to investigate amino acid metabolism in filamentous, heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120.
Wed Oct 01 00:00:00 UTC 2014
Morphological and physiological properties of enhanced green fluorescent protein (EGFP)-expressing wide-field amacrine cells in the ChAT-EGFP mouse line.
The European journal of neuroscience
Knop GC,Pottek M,Monyer H,Weiler R,Dedek K
A-6455 was used in immunohistochemistry to use a GFP-transgenic mouse model to study a single wide-field amacrine cell population monostratifying in layer 2/3 of the inner plexiform layer
Sat Mar 01 00:00:00 UTC 2014
Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila.
Frontiers in behavioral neuroscience
Vasmer D,Pooryasin A,Riemensperger T,Fiala A
A-6455 was used in immunohistochemistry to test if the mushroom body is sufficient to acquire and retrieve an associative memory.
Mon May 26 00:00:00 UTC 2014
The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors.
Molecular biology of the cell
Soppina V,Verhey KJ
A-6455 was used in western blot to study kinesin-3 motors.
Tue Jul 15 00:00:00 UTC 2014
Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.
Virology
Maric M,Haugo AC,Dauer W,Johnson D,Roller RJ
A-6455 was used in western blot to study nuclear envelope break down during herpesvirus infection
Tue Jul 01 00:00:00 UTC 2014
LC3B is indispensable for selective autophagy of p62 but not basal autophagy.
Biochemical and biophysical research communications
Maruyama Y,Sou YS,Kageyama S,Takahashi T,Ueno T,Tanaka K,Komatsu M,Ichimura Y
A-6455 was used in western blot to elucidate the roles of LC3 and GABARAP families in basal and selective autophagy.
Fri Mar 28 00:00:00 UTC 2014
PTEN knockdown alters dendritic spine/protrusion morphology, not density.
The Journal of comparative neurology
Haws ME,Jaramillo TC,Espinosa F,Widman AJ,Stuber GD,Sparta DR,Tye KM,Russo SJ,Parada LF,Stavarache M,Kaplitt M,Bonci A,Powell CM
A-6455 was used in immunohistochemistry (free floating) to describe the synaptic changes in neurons lacking PTEN.
Tue Apr 01 00:00:00 UTC 2014
Differential regulation of CASZ1 protein expression during cardiac and skeletal muscle development.
Developmental dynamics : an official publication of the American Association of Anatomists
Amin NM,Gibbs D,Conlon FL
A-6455 was used in immunohistochemistry to investigate Casz1 in the heart.
Tue Jul 01 00:00:00 UTC 2014
Serotonergic neurons of the Drosophila air-puff-stimulated flight circuit.
Journal of biosciences
Sadaf S,Hasan G
A-6455 was used in immunohistochemistry to study serotonergic neurons during air-puff-stimulated flight.
Mon Sep 01 00:00:00 UTC 2014
Notch inhibits Yorkie activity in Drosophila wing discs.
PloS one
Djiane A,Zaessinger S,Babaoğlan AB,Bray SJ
A-6455 was used in immunohistochemistry to investigate the cross-talk between the Notch and SWH pathways in wing discs
Mon Dec 21 00:00:00 UTC 2015
An upstream open reading frame regulates LST1 expression during monocyte differentiation.
PloS one
Schiller C,Nowak C,Diakopoulos KN,Weidle UH,Weiss EH
A-6455 was used in flow cytometry to test if uORFs regulate the expression of the MHC class III gene LST1.
Mon Oct 19 00:00:00 UTC 2015
Ion antiport accelerates photosynthetic acclimation in fluctuating light environments.
Nature communications
Armbruster U,Carrillo LR,Venema K,Pavlovic L,Schmidtmann E,Kornfeld A,Jahns P,Berry JA,Kramer DM,Jonikas MC
A-6455 was used in western blot to describe a mechanism that increases the efficiency of photosynthesis under fluctuating light
Thu Nov 13 00:00:00 UTC 2014
CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1.
PloS one
Sakamoto T,Kobayashi M,Tada K,Shinohara M,Io K,Nagata K,Iwai F,Takiuchi Y,Arai Y,Yamashita K,Shindo K,Kadowaki N,Koyanagi Y,Takaori-Kondo A
A-6455 was used in western blot to show that CKIP-1 interacts with CARMA1 and inhibits PKCθ-CBM-NF-κB signaling.
Thu Sep 18 00:00:00 UTC 2014
Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.
PLoS genetics
Chen D,Wu C,Zhao S,Geng Q,Gao Y,Li X,Zhang Y,Wang Z
A-6455 was used in immunocytochemistry to determine the contribution of Tut, Bam, and Bgcn in the proliferation and differentiation of the Drosophila germline stem cell lineage
Sat Nov 01 00:00:00 UTC 2014
The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization.
G3 (Bethesda, Md.)
Atencio D,Barnes C,Duncan TM,Willis IM,Hanes SD
A-6455 was used in western blot to elucidate Ess1/Pin1 function.
Thu Mar 20 00:00:00 UTC 2014
Using an α-bungarotoxin binding site tag to study GABA A receptor membrane localization and trafficking.
Journal of visualized experiments : JoVE
Brady ML,Moon CE,Jacob TC
A-6455 was used in immunocytochemistry to describe and use a method to study receptor cell surface localization and endocytosis.
Fri Mar 28 00:00:00 UTC 2014
Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion.
Nature communications
Gradilla AC,González E,Seijo I,Andrés G,Bischoff M,González-Mendez L,Sánchez V,Callejo A,Ibáñez C,Guerra M,Ortigão-Farias JR,Sutherland JD,González M,Barrio R,Falcón-Pérez JM,Guerrero I
A-6455 was used in immunohistochemistry to investigate how transport Hedgehog via exosomes along cytonemes helps establish a gradient of expression.
Thu Dec 04 00:00:00 UTC 2014
Structural and enzymatic characterization of a host-specificity determinant from Salmonella.
Acta crystallographica. Section D, Biological crystallography
Kohler AC,Spanò S,Galán JE,Stebbins CE
A-6455 was used in Western Blot to present the crystal structure of GtgE at 1.65 Å resolution and identify its catalytic triad.
Sat Feb 01 00:00:00 UTC 2014
Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice.
PloS one
Dugué GP,Lörincz ML,Lottem E,Audero E,Matias S,Correia PA,Léna C,Mainen ZF
A-6455 was used in immunohistochemistry - frozen section to study the firing of dorsal raphe serotonergic neurons.
Thu Mar 17 00:00:00 UTC 2016
PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.
Nature communications
Calebiro D,Hannawacker A,Lyga S,Bathon K,Zabel U,Ronchi C,Beuschlein F,Reincke M,Lorenz K,Allolio B,Kisker C,Fassnacht M,Lohse MJ
A-6455 was used in western blot to study two mutants of protein kinase A with enhanced catalytic activity
Fri Dec 05 00:00:00 UTC 2014
Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).
PloS one
Renner I,Funk N,Geissler R,Friedrich S,Penzel A,Behrens SE
A-6455 was used in western blot to describe the use of transcription activator-like effectors to study host-virus interactions
Mon Dec 21 00:00:00 UTC 2015
Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.
PLoS genetics
Cho HH,Cargnin F,Kim Y,Lee B,Kwon RJ,Nam H,Shen R,Barnes AP,Lee JW,Lee S,Lee SK
A-6455 was used in immunohistochemistry - frozen section to study cholinergic neuronal identity in developing spinal cord and forebrain by forming cell type-specific complexes controlled by IsI1
Tue Apr 01 00:00:00 UTC 2014
The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells.
PloS one
Bello-Morales R,Crespillo AJ,García B,Dorado LÁ,Martín B,Tabarés E,Krummenacher C,de Castro F,López-Guerrero JA
A-6455 was used in western blot to investigate the effect of oligodendrocytic cell maturation on HSV-1 infection.
Tue Oct 14 00:00:00 UTC 2014
EndMT contributes to the onset and progression of cerebral cavernous malformations.
Nature
Maddaluno L,Rudini N,Cuttano R,Bravi L,Giampietro C,Corada M,Ferrarini L,Orsenigo F,Papa E,Boulday G,Tournier-Lasserve E,Chapon F,Richichi C,Retta SF,Lampugnani MG,Dejana E
A-6455 was used in immunohistochemistry to study the role of endothelial-to-mesenchymal transition in the onset and progression of cerebral cavernous malformations
Thu Jun 27 00:00:00 UTC 2013
Differential L1 regulation in pluripotent stem cells of humans and apes.
Nature
Marchetto MCN,Narvaiza I,Denli AM,Benner C,Lazzarini TA,Nathanson JL,Paquola ACM,Desai KN,Herai RH,Weitzman MD,Yeo GW,Muotri AR,Gage FH
A-6455 was used in immunocytochemistry to use induced pluripotent stem cells to study long interspersed element-1 transposons in humans and non-human primates
Thu Nov 28 00:00:00 UTC 2013
A two-step mechanism for TRF2-mediated chromosome-end protection.
Nature
Okamoto K,Bartocci C,Ouzounov I,Diedrich JK,Yates JR,Denchi EL
A-6455 was used in immunocytochemistry to study how TRF2 protects chromosome ends.
Thu Feb 28 00:00:00 UTC 2013
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.
Nature neuroscience
Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S
A-6455 was used in immunohistochemistry to discuss the contribution of the accessory olfactory bulb to social behavior.
Fri Feb 01 00:00:00 UTC 2013
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
Nature neuroscience
Viganò F,Möbius W,Götz M,Dimou L
A-6455 was used in immunohistochemistry to investigate oligodendrocyte differentiation in the adult brain.
Tue Oct 01 00:00:00 UTC 2013
Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.
Nature neuroscience
Dus M,Ai M,Suh GS
A-6455 was used in immunohistochemistry to study SLC5A in food selection using Drosophila.
Wed May 01 00:00:00 UTC 2013
Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia.
Nature cell biology
Bischoff M,Gradilla AC,Seijo I,Andrés G,Rodríguez-Navas C,González-Méndez L,Guerrero I
A-6455 was used in immunohistochemistry - frozen section to determine the mechanism underlying Hedgehog movement in the wing disc and the abdominal epidermis of Drosophila melanogaster
Fri Nov 01 00:00:00 UTC 2013
Sustained IL-1β expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.
Brain, behavior, and immunity
Wu MD,Montgomery SL,Rivera-Escalera F,Olschowka JA,O'Banion MK
A-6455 was used in immunohistochemistry - free floating to elucidate the role of IL-β during neurogenesis.
Thu Aug 01 00:00:00 UTC 2013
Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
Developmental cell
Efroni I,Han SK,Kim HJ,Wu MF,Steiner E,Birnbaum KD,Hong JC,Eshed Y,Wagner D
A-6455 was used in immunocytochemistry to study the role of cytokinin in determinate leaf growth.
Mon Feb 25 00:00:00 UTC 2013
ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation.
Genes & development
Zhang W,Hietakangas V,Wee S,Lim SC,Gunaratne J,Cohen SM
A-6455 was used in immunocytochemistry to elucidate how endoplasmic reticulum stress affects insulin responses.
Fri Feb 15 00:00:00 UTC 2013
Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes.
The Journal of cell biology
Yi K,Rubinstein B,Unruh JR,Guo F,Slaughter BD,Li R
A-6455 was used in immunocytochemistry to investigate the role of Fmn2 in spindle formation.
Mon Mar 04 00:00:00 UTC 2013
Evolutionary comparisons reveal a positional switch for spindle pole oscillations in Caenorhabditis embryos.
The Journal of cell biology
Riche S,Zouak M,Argoul F,Arneodo A,Pecreaux J,Delattre M
A-6455 was used in western blot to compare the regulation of the cortical Gα-GPR-LIN-5 complex in C. elegans and C. briggsae.
Mon May 27 00:00:00 UTC 2013
Olfactory ensheathing cells form the microenvironment of migrating GnRH-1 neurons during mouse development.
Glia
Geller S,Kolasa E,Tillet Y,Duittoz A,Vaudin P
A-6455 was used in immunocytochemistry to study the effect of the microenvironment on the migration of GnRH- neurons.
Mon Apr 01 00:00:00 UTC 2013
Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication.
PLoS pathogens
Caffarelli N,Fehr AR,Yu D
A-6455 was used in immunoprecipitation to study the ability of primate CMV pUL21a to degrade cyclin A and the implications for virus replication.
Wed Sep 03 00:00:00 UTC 2014
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
Development (Cambridge, England)
Yang S,Edman LC,Sánchez-Alcañiz JA,Fritz N,Bonilla S,Hecht J,Uhlén P,Pleasure SJ,Villaescusa JC,Marín O,Arenas E
A-6455 was used in immunohistochemistry to test if CXCL2/CXCR4 signaling contributes to the development of A9-A0 tyrosine hydroxylase positive midbrain dopaminergic neurons.
Fri Nov 01 00:00:00 UTC 2013
Role of the medial prefrontal cortex in cataplexy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Oishi Y,Williams RH,Agostinelli L,Arrigoni E,Fuller PM,Mochizuki T,Saper CB,Scammell TE
A-6455 was used in immunohistochemistry - frozen section to use orexin knock-out mice as a model of narcolepsy to study the effects of strong emotions.
Wed Jun 05 00:00:00 UTC 2013
Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dhande OS,Estevez ME,Quattrochi LE,El-Danaf RN,Nguyen PL,Berson DM,Huberman AD
A-6455 was used in immunohistochemistry to study which types of retinal ganglion cells project to each of the accessory optic system nuclei.
Wed Nov 06 00:00:00 UTC 2013
GnRH neurons elaborate a long-range projection with shared axonal and dendritic functions.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Herde MK,Iremonger KJ,Constantin S,Herbison AE
A-6455 was used in immunohistochemistry to study gonadotropin-releasing hormone neurons.
Wed Jul 31 00:00:00 UTC 2013
FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ena SL,De Backer JF,Schiffmann SN,de Kerchove d'Exaerde A
A-6455 was used in immunohistochemistry - frozen section to identify specific STP and STN neuron gene profiles.
Wed May 15 00:00:00 UTC 2013
The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100).
Molecular cancer research : MCR
Shimojo M,Shudo Y,Ikeda M,Kobashi T,Ito S
A-6455 was used in western blot to elucidate the extracellular matrix-dependent signaling pathway that impacts nSR100 expression and its regulation of alternative splicing in small cell lung cancer.
Tue Oct 01 00:00:00 UTC 2013
CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Billet A,Mornon JP,Jollivet M,Lehn P,Callebaut I,Becq F
A-6455 was used in western blot to distinguish CFTR from standard ABC transporters.
Sun Dec 01 00:00:00 UTC 2013
Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1.
Journal of cell science
Rodgers LS,Beam MT,Anderson JM,Fanning AS
A-6455 was used in western blot to characterize ZO-1 binding domains.
Mon Apr 01 00:00:00 UTC 2013
Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location.
Investigative ophthalmology & visual science
Feng L,Zhao Y,Yoshida M,Chen H,Yang JF,Kim TS,Cang J,Troy JB,Liu X
A-6455 was used in immunohistochemistry to study retinal ganglion cell degeneration in a mouse model of ocular hypertension.
Thu Feb 07 00:00:00 UTC 2013
Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cells.
Pflugers Archiv : European journal of physiology
Matsuoka H,Harada K,Nakamura J,Inoue M
A-6455 was used in immunocytochemistry to investigate how the expression and localization of TASK channels are regulated in rat adrenal medullary cells and PC2 cells.
Mon Jul 01 00:00:00 UTC 2013
p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells.
FEBS letters
Hayashi A,Hiatari R,Tsuji T,Ohashi K,Mizuno K
A-6455 was used in western blot to determine the role of p63RhoGEF in serum-induced chemotaxis.
Mon Mar 18 00:00:00 UTC 2013
A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.
Cell stress & chaperones
Sone M,Zeng X,Larese J,Ryoo HD
A-6455 was used in western blot to elucidate the role of the IRE1/XBP1 pathway during normal development and homeostasis.
Wed May 01 00:00:00 UTC 2013
Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration.
Frontiers in behavioral neuroscience
Bass CE,Grinevich VP,Gioia D,Day-Brown JD,Bonin KD,Stuber GD,Weiner JL,Budygin EA
A-6455 was used in immunohistochemistry to show that a viral targeting strategy can be used to restrict opsin expression to dopamine cells in animals and provide the first causal evidence demonstrating that tonic activation of VTA dopamine neurons selectively decreases ethanol self-adminis.
Tue Dec 10 00:00:00 UTC 2013
Variation in vasopressin receptor (Avpr1a) expression creates diversity in behaviors related to monogamy in prairie voles.
Hormones and behavior
Barrett CE,Keebaugh AC,Ahern TH,Bass CE,Terwilliger EF,Young LJ
A-6455 was used in western blot to investigate the causal relationship between intraspecific variation in V1aR and behavioral outcomes in prairie voles.
Fri Mar 01 00:00:00 UTC 2013
Effects of in vivo applications of peripheral blood-derived mesenchymal stromal cells (PB-MSCs) and platlet-rich plasma (PRP) on experimentally injured deep digital flexor tendons of sheep.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Martinello T,Bronzini I,Perazzi A,Testoni S,De Benedictis GM,Negro A,Caporale G,Mascarello F,Iacopetti I,Patruno M
A-6455 was used in immunohistochemistry to assess the use of autologous mesenchymal stromal cells derived from peripheral blood, platelet-rich plasma. and a combination of both for ameliorating experimental lesions on deep digital flexor tendons of sheep.
Fri Feb 01 00:00:00 UTC 2013
The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions.
PeerJ
Wozniak MA,Baker BM,Chen CS,Wilson KL
A-6455 was used in immunoprecipitation to test if Lmo7 misregulation contributes to X-linked Emery-Dreifuss muscular dystrophy.
Fri Sep 06 00:00:00 UTC 2013
Functional characterization of the human mariner transposon Hsmar2.
PloS one
Gil E,Bosch A,Lampe D,Lizcano JM,Perales JC,Danos O,Chillon M
A-6455 was used in western blot to study the evolution and function of the Hsmar2 transposon.
Sun Jun 15 00:00:00 UTC 2014
Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth.
The Journal of biological chemistry
Adler JJ,Heller BL,Bringman LR,Ranahan WP,Cocklin RR,Goebl MG,Oh M,Lim HS,Ingham RJ,Wells CD
A-6455 was used in western blot to report that Amot130 binds and activates AIP4/Itch to regulate cell growth.
Fri May 24 00:00:00 UTC 2013
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
The Journal of biological chemistry
Okatsu K,Uno M,Koyano F,Go E,Kimura M,Oka T,Tanaka K,Matsuda N
A-6455 was used in western blot to investigate the molecular mechanism that result in PINK1-mediated dissipation of the mitochondrial membrane potential.
Fri Dec 20 00:00:00 UTC 2013
Assembly of synapses: biomimetic assays to control neurexin/neuroligin interactions at the neuronal surface.
Current protocols in neuroscience
Mondin M,Tessier B,Thoumine O
A-6455 was used in Immunohistochemistry to characterize the role of neurexin/neuroligin adhesion complexes in synapse differentiation.
Mon Jul 01 00:00:00 UTC 2013
Lulu regulates Shroom-induced apical constriction during neural tube closure.
PloS one
Chu CW,Gerstenzang E,Ossipova O,Sokol SY
A-6455 was used in immunohistochemistry to study apical constriction dependent on Shroom3 and EPB4.1l5 within neural tube closure.
Tue Aug 05 00:00:00 UTC 2014
Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.
The Journal of biological chemistry
Tanaka K,Kondo K,Kitajima K,Muraoka M,Nozawa A,Hara T
A-6455 was used in immunohistochemistry - paraffin section to study the function and regulation of protein-tyrosine phosphatase non-receptor type in the formation of testicular germ cell tumors.
Fri Aug 16 00:00:00 UTC 2013
Genome-wide and cell-specific epigenetic analysis challenges the role of polycomb in Drosophila spermatogenesis.
PLoS genetics
El-Sharnouby S,Redhouse J,White RA
A-6455 was used in immunohistochemistry to assess the genome-wide binding of Polycomb in wild type and tTAF mutant testes.
Thu Mar 20 00:00:00 UTC 2014
Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye.
PloS one
Suzuki T,Shimoda M,Ito K,Hanai S,Aizawa H,Kato T,Kawasaki K,Yamaguchi T,Ryoo HD,Goto-Inoue N,Setou M,Tsuji S,Ishida N
A-6455 was used in immunohistochemistry to identify a novel mechanism of neurodevelopmental defects mediated by endoplasmic reticulum stress through expression of mutants of human GBA gene in the eye of Drosophila.
Mon Apr 28 00:00:00 UTC 2014
Mitochondrial AtPAM16 is required for plant survival and the negative regulation of plant immunity.
Nature communications
Huang Y,Chen X,Liu Y,Roth C,Copeland C,McFarlane HE,Huang S,Lipka V,Wiermer M,Li X
A-6455 was used in western blot to demonstrate that AtPAM16 imports a negative regulator of plant immunity into mitochondria.
Thu Jun 12 00:00:00 UTC 2014
Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
PloS one
Sato S,Zhao Y,Imai M,Simister PC,Feller SM,Trackman PC,Kirsch KH,Sonenshein GE
A-6455 was used in immunoprecipitation and western blot to show that LOX-PP interacts with CIN85 and that this association reduces CIN85-promoted invasion by breast cancer cells.
Wed May 28 00:00:00 UTC 2014
Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe.
Cell death & disease
Hashizume C,Kobayashi A,Wong RW
A-6455 was used in immunocytochemistry, immunoprecipitation, and western blot to study the role of nucleoporin RanBP2/Nup358 in chromosomal alignment and mitotic integrity.
Thu Oct 10 00:00:00 UTC 2013
Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila.
BMC neuroscience
Subramanian M,Jayakumar S,Richhariya S,Hasan G
A-6455 was used in immunohistochemistry to study IP3R Drosophila mutants.
Wed Dec 18 00:00:00 UTC 2013
Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.
Journal of cell science
Nagai T,Ikeda M,Chiba S,Kanno S,Mizuno K
A-6455 was used in Immunocytochemistry to suggest that Fry plays a crucial role in promoting the level of MT acetylation in the mitotic spindle by inhibiting the tubulin-deacetylase activity of SIRT2.
Tue Oct 01 00:00:00 UTC 2013
Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.
Journal of cell science
Nagai T,Ikeda M,Chiba S,Kanno S,Mizuno K
A-6455 was used in Immunocytochemistry to suggest that Fry plays a crucial role in promoting the level of MT acetylation in the mitotic spindle by inhibiting the tubulin-deacetylase activity of SIRT2.
Tue Oct 01 00:00:00 UTC 2013
Mushroom body miscellanea: transgenic Drosophila strains expressing anatomical and physiological sensor proteins in Kenyon cells.
Frontiers in neural circuits
Pech U,Dipt S,Barth J,Singh P,Jauch M,Thum AS,Fiala A,Riemensperger T
A-6455 was used in immunohistochemistry - frozen section to compile fruit flies that express transgenes under direct control of the Kenyon-cell specific promoter, mb247.
Tue Apr 08 00:00:00 UTC 2014
High-level intracellular expression of heterologous proteins in Brevibacillus choshinensis SP3 under the control of a xylose inducible promoter.
Microbial cell factories
D'Urzo N,Martinelli M,Nenci C,Brettoni C,Telford JL,Maione D
A-6455 was used in immunocytochemistry to generate a PxylA inducible promoter in Brevibacillus.
Fri Feb 01 00:00:00 UTC 2013
Imaging of phenotypes, gene expression, and protein localization during embryonic root formation in Arabidopsis.
Methods in molecular biology (Clifton, N.J.)
Llavata-Peris C,Lokerse A,Möller B,De Rybel B,Weijers D
A-6455 was used in Immunocytochemistry to describe methods for analysis of mutant phenotypes, fluorescent reporter gene expression and protein localization in Arabidopsis embryos, and show how these methods can be used to visualize key factors in embryonic root formation.
Wed Jun 19 00:00:00 UTC 2013
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
PloS one
Paemka L,Mahajan VB,Skeie JM,Sowers LP,Ehaideb SN,Gonzalez-Alegre P,Sasaoka T,Tao H,Miyagi A,Ueno N,Takao K,Miyakawa T,Wu S,Darbro BW,Ferguson PJ,Pieper AA,Britt JK,Wemmie JA,Rudd DS,Wassink T,El-Shanti H,Mefford HC,Carvill GL,Manak JR,Bassuk AG
A-6455 was used in immunohistochemistry to determine the role of PRICKLE in autism spectrum disorders.
Mon Aug 18 00:00:00 UTC 2014
Insect pheromone behavior: fruit fly.
Methods in molecular biology (Clifton, N.J.)
Yamamoto D,Kohatsu S,Koganezawa M
A-6455 was used in Immunohistochemistry-immunofluorescence to describe technical details of these assays.
Mon Mar 31 00:00:00 UTC 2014
Body wall development in lamprey and a new perspective on the origin of vertebrate paired fins.
Proceedings of the National Academy of Sciences of the United States of America
Tulenko FJ,McCauley DW,Mackenzie EL,Mazan S,Kuratani S,Sugahara F,Kusakabe R,Burke AC
A-6455 was used in Immunohistochemistry to hypothesize that a persistent somatopleure in the lateral body wall is a gnathostome synapomorphy, and the redistribution of LPM was a key step in generating the novel developmental module that ultimately produced paired fins.
Tue Jul 16 00:00:00 UTC 2013
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.
Nature medicine
McIntyre JC,Davis EE,Joiner A,Williams CL,Tsai IC,Jenkins PM,McEwen DP,Zhang L,Escobado J,Thomas S,Szymanska K,Johnson CA,Beales PL,Green ED,Mullikin JC,Sabo A,Muzny DM,Gibbs RA,Attié-Bitach T,Yoder BK,Reed RR,Katsanis N,Martens JR
A-6455 was used in immunohistochemistry - frozen section to investigate gene therapy methods to treat ciliopathies.
Sat Sep 01 00:00:00 UTC 2012
Tracking protein aggregation and mislocalization in cells with flow cytometry.
Nature methods
Ramdzan YM,Polling S,Chia CP,Ng IH,Ormsby AR,Croft NP,Purcell AW,Bogoyevitch MA,Ng DC,Gleeson PA,Hatters DM
A-6455 was used in western blot to use pulse-shape analysis to monitor protein localization changes in an in vitro model of Huntington's disease by flow cytometry.
Sun Mar 18 00:00:00 UTC 2012
Drosophila patterning is established by differential association of mRNAs with P bodies.
Nature cell biology
Weil TT,Parton RM,Herpers B,Soetaert J,Veenendaal T,Xanthakis D,Dobbie IM,Halstead JM,Hayashi R,Rabouille C,Davis I
A-6455 was used in immunocytochemistry to study differential translational regulation in axis specification.
Sat Dec 01 00:00:00 UTC 2012
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nature structural & molecular biology
Cui G,Park S,Badeaux AI,Kim D,Lee J,Thompson JR,Yan F,Kaneko S,Yuan Z,Botuyan MV,Bedford MT,Cheng JQ,Mer G
A-6455 was used in immunoprecipitation to report that PHF20 is a direct regulator of p53.
Sat Sep 01 00:00:00 UTC 2012
Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages.
Proceedings of the National Academy of Sciences of the United States of America
Redrejo-Rodríguez M,Muñoz-Espín D,Holguera I,Mencía M,Salas M
A-6455 was used in immunocytochemistry to elucidate mechanisms that promote horizontal transfer of genes between prokaryotes and eukaryotes.
Tue Nov 06 00:00:00 UTC 2012
Identification of PAN2 by quantitative proteomics as a leucine-rich repeat-receptor-like kinase acting upstream of PAN1 to polarize cell division in maize.
The Plant cell
Zhang X,Facette M,Humphries JA,Shen Z,Park Y,Sutimantanapi D,Sylvester AW,Briggs SP,Smith LG
A-6455 was used in western blot to study the roles of PAN1 and PAN2 in the polarization of maize cell division.
Thu Nov 01 00:00:00 UTC 2012
Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress.
Cell death and differentiation
Poels J,Spasić MR,Gistelinck M,Mutert J,Schellens A,Callaerts P,Norga KK
A-6455 was used in immunohistochemistry - frozen section to examine the impact of autophagy in neuronal cell death and survival under conditions of altered energy supply.
Mon Oct 01 00:00:00 UTC 2012
The Calmodulin-like calcium binding protein EhCaBP3 of Entamoeba histolytica regulates phagocytosis and is involved in actin dynamics.
PLoS pathogens
Aslam S,Bhattacharya S,Bhattacharya A
A-6455 was used in western blot to elucidate pathways that regulate phagocytosis in Entamoeba histolytica
Sat Dec 01 00:00:00 UTC 2012
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.
PLoS pathogens
Fehr AR,Gualberto NC,Savaryn JP,Terhune SS,Yu D
A-6455 was used in western blot to study the role of the proteasome in the disruption of the anaphase-promoting complex by the pUL21a protein of human CMV.
Tue Jan 29 00:00:00 UTC 2013
Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.
Development (Cambridge, England)
Zhu G,Chow LM,Bayazitov IT,Tong Y,Gilbertson RJ,Zakharenko SS,Solecki DJ,Baker SJ
A-6455 was used in immunohistochemistry - paraffin section to study the PI3K-Akt-mTorc pathway in neuron development.
Sat Sep 01 00:00:00 UTC 2012
Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture, brain morphology, and associative learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volders K,Scholz S,Slabbaert JR,Nagel AC,Verstreken P,Creemers JW,Callaerts P,Schwärzel M
A-6455 was used in immunohistochemistry to elucidate the molecular function of rugose.
Wed Oct 24 00:00:00 UTC 2012
Consolidated and labile odor memory are separately encoded within the Drosophila brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Scheunemann L,Jost E,Richlitzki A,Day JP,Sebastian S,Thum AS,Efetova M,Davies SA,Schwärzel M
A-6455 was used in immunohistochemistry to study the impact of cAMP signals on memory.
Wed Nov 28 00:00:00 UTC 2012
Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen YK,Hsueh YP
A-6455 was used in immunocytochemistry to characterize the distribution and function of neuron-predominant cortactin-binding protein 2 in rodents.
Wed Jan 18 00:00:00 UTC 2012
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.
Human molecular genetics
Ashe A,Butterfield NC,Town L,Courtney AD,Cooper AN,Ferguson C,Barry R,Olsson F,Liem KF,Parton RG,Wainwright BJ,Anderson KV,Whitelaw E,Wicking C
A-6455 was used in western blot to characterize mice with a hypomorphic missense mutation in the Ift144 gene.
Sun Apr 15 00:00:00 UTC 2012
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Genetics
Neumüller RA,Wirtz-Peitz F,Lee S,Kwon Y,Buckner M,Hoskins RA,Venken KJ,Bellen HJ,Mohr SE,Perrimon N
A-6455 was used in immunoprecipitation to use fluorescent traps to study of endogenous protein complexes in Drosophila.
Thu Mar 01 00:00:00 UTC 2012
Myosin Vs organize actin cables in fission yeast.
Molecular biology of the cell
Lo Presti L,Chang F,Martin SG
A-6455 was used in immunoprecipitation to show a role for Myosin Vs in assembling actin cables.
Sat Dec 01 00:00:00 UTC 2012
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.
Molecular biology of the cell
Velikkakath AK,Nishimura T,Oita E,Ishihara N,Mizushima N
A-6455 was used in western blot to identify and characterize Atg2A and Atg2B.
Thu Mar 01 00:00:00 UTC 2012
CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex.
Molecular biology of the cell
Chen YK,Chen CY,Hu HT,Hsueh YP
A-6455 was used in immunohistochemistry to investigate how CTTNBP2, cortactin and PP2A complex interactions regulate spine morphogenesis and synaptic signaling.
Thu Nov 01 00:00:00 UTC 2012
The spanin complex is essential for lambda lysis.
Journal of bacteriology
Berry J,Rajaure M,Pang T,Young R
A-6455 was used in western blot to investigate spanins.
Mon Oct 01 00:00:00 UTC 2012
Nuclear translocation of FGF8 and its implication to induce Sprouty2.
Development, growth & differentiation
Suzuki A,Harada H,Nakamura H
A-6455 was used in immunohistochemistry to test if FGF8 localizes in nuclei and function in the nucleus.
Tue May 01 00:00:00 UTC 2012
Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophila mushroom body calyx.
The Journal of comparative neurology
Butcher NJ,Friedrich AB,Lu Z,Tanimoto H,Meinertzhagen IA
A-6455 was used in immunohistochemistry to examine how sensory information is processed, transformed, and stored within an olfactory system.
Sun Jul 01 00:00:00 UTC 2012
The role of octopamine and tyramine in Drosophila larval locomotion.
The Journal of comparative neurology
Selcho M,Pauls D,El Jundi B,Stocker RF,Thum AS
A-6455 was used in immunohistochemistry to elucidate the role of octopaminergic/tyraminergic neurons in movement.
Thu Nov 01 00:00:00 UTC 2012
Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system.
PLoS genetics
Eade KT,Fancher HA,Ridyard MS,Allan DW
A-6455 was used in immunohistochemistry to study how neuronal subtype identity maintained.
Thu Feb 21 00:00:00 UTC 2013
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
BMC microbiology
Bello-Morales R,Crespillo AJ,Fraile-Ramos A,Tabarés E,Alcina A,López-Guerrero JA
A-6455 was used in immunocytochemistry to elucidate the role of Rab27a in HSV- infection.
Mon Nov 19 00:00:00 UTC 2012
Restricted transgene expression in the brain with cell-type specific neuronal promoters.
Human gene therapy methods
Delzor A,Dufour N,Petit F,Guillermier M,Houitte D,Auregan G,Brouillet E,Hantraye P,Déglon N
A-6455 was used in immunohistochemistry to develop vectors to deliver therapeutic molecules into the central nervous system.
Wed Aug 01 00:00:00 UTC 2012
Measurement of autophagic activity in mammalian cells.
Current protocols in cell biology
Menzies FM,Moreau K,Puri C,Renna M,Rubinsztein DC
A-6455 was used in immunocytochemistry to discuss autophagy assays.
Thu Mar 01 00:00:00 UTC 2012
X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7.
FEBS letters
Nagano T,Hashimoto T,Nakashima A,Kikkawa U,Kamada S
A-6455 was used in Immunoprecipitation to reveal that XIAP does not function as a NEDD8-E3 ligase for caspase-7 in vivo.
Mon Jun 04 00:00:00 UTC 2012
Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.
PloS one
Yang T,Puckerin A,Colecraft HM
A-6455 was used in western blot to examine how Rad/Rem/Rem2/Gem GTPases blocks I(Ca).
Wed Sep 19 00:00:00 UTC 2012
Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae.
Developmental cell
Suzuki K,Morimoto M,Kondo C,Ohsumi Y
A-6455 was used in immunoprecipitation to assess the effects of autophagy on Ty1 transposons.
Tue Aug 16 00:00:00 UTC 2011
Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes.
Autophagy
Shvets E,Abada A,Weidberg H,Elazar Z
A-6455 was used in immunocytochemistry, immunoprecipitation, and western blot to study how LC3 is contributes to p62 incorporation into autophagosomes.
Fri Jul 01 00:00:00 UTC 2011
Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes.
Autophagy
Shvets E,Abada A,Weidberg H,Elazar Z
A-6455 was used in immunocytochemistry, immunoprecipitation, and western blot to study how LC3 is contributes to p62 incorporation into autophagosomes.
Fri Jul 01 00:00:00 UTC 2011
Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes.
Autophagy
Shvets E,Abada A,Weidberg H,Elazar Z
A-6455 was used in immunocytochemistry, immunoprecipitation, and western blot to study how LC3 is contributes to p62 incorporation into autophagosomes.
Fri Jul 01 00:00:00 UTC 2011
Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies.
American journal of human genetics
Southgate L,Machado RD,Snape KM,Primeau M,Dafou D,Ruddy DM,Branney PA,Fisher M,Lee GJ,Simpson MA,He Y,Bradshaw TY,Blaumeiser B,Winship WS,Reardon W,Maher ER,FitzPatrick DR,Wuyts W,Zenker M,Lamarche-Vane N,Trembath RC
A-6455 was used in western blot to identify mutations that contribute to the development of Adams-Oliver syndrome.
Fri May 13 00:00:00 UTC 2011
Periodic organization of a major subtype of pyramidal neurons in neocortical layer V.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Maruoka H,Kubota K,Kurokawa R,Tsuruno S,Hosoya T
A-6455 was used in immunohistochemistry to determine if the distribution of neuronal subtypes is random or has any stereotypy.
Wed Dec 14 00:00:00 UTC 2011
Switching control of sympathetic activity from forebrain to hindbrain in chronic dehydration.
The Journal of physiology
Colombari DS,Colombari E,Freiria-Oliveira AH,Antunes VR,Yao ST,Hindmarch C,Ferguson AV,Fry M,Murphy D,Paton JF
A-6455 was used in immunohistochemistry to elucidate mechanisms that regulate increased blood pressure and sympathetic nerve activity caused by dehydration.
Thu Sep 15 00:00:00 UTC 2011
An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer.
The American journal of pathology
Karhemo PR,Rivinoja A,Lundin J,Hyvönen M,Chernenko A,Lammi J,Sihto H,Lundin M,Heikkilä P,Joensuu H,Bono P,Laakkonen P
A-6455 was used in western blot to examine the role of nucleophosmin in solid cancers.
Mon Aug 01 00:00:00 UTC 2011
The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells.
Molecular and cellular biology
Sánchez-Morgan N,Kirsch KH,Trackman PC,Sonenshein GE
A-6455 was used in western blot to show that LOX-PP negatively regulates β-catenin signaling in lung cancer cells.
Mon Aug 01 00:00:00 UTC 2011
Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat.
Pflugers Archiv : European journal of physiology
Poulsen AN,Jansen-Olesen I,Olesen J,Klaerke DA
A-6455 was used in western blot to investigate splice variants of the big conductance calcium-activated K(+) channel
Sat Jan 01 00:00:00 UTC 2011
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.
Molecular biology of the cell
Herzog B,Pellet-Many C,Britton G,Hartzoulakis B,Zachary IC
A-6455 was used in immunocytochemistry to identify residues of the NRP b domain needed for VEGF binding.
Mon Aug 01 00:00:00 UTC 2011
Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR.
The Journal of experimental biology
Birse RT,Söderberg JA,Luo J,Winther AM,Nässel DR
A-6455 was used in immunocytochemistry to study the regulation of Drosophila insulin-like peptides production and release in adult fruit flies.
Thu Dec 15 00:00:00 UTC 2011
Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1.
Journal of biochemistry
Maemoto Y,Osako Y,Goto E,Nozawa E,Shibata H,Maki M
A-6455 was used in western blot to elucidate domains needed for CHMP1B to interact with other proteins.
Sat Oct 01 00:00:00 UTC 2011
Involvement of the Drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions.
The Journal of comparative neurology
Besson MT,Sinakevitch I,Melon C,Iché-Torres M,Birman S
A-6455 was used in immunocytochemistry to investigate the expression and function of excitatory amino acid transporters.
Sat Oct 01 00:00:00 UTC 2011
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system.
The Journal of comparative neurology
Kim EJ,Hori K,Wyckoff A,Dickel LK,Koundakjian EJ,Goodrich LV,Johnson JE
A-6455 was used in immunohistochemistry to investigate the migration and maturation of neurogenin1 neurons in the rodent central nervous system.
Sun May 01 00:00:00 UTC 2011
Molecular and neuroanatomical characterization of single neurons in the mouse medullary gigantocellular reticular nucleus.
The Journal of comparative neurology
Martin EM,Devidze N,Shelley DN,Westberg L,Fontaine C,Pfaff DW
A-6455 was used in immunocytochemistry to determine the neuroanatomical and molecular characteristics of medullary gigantocellular reticular nucleus neurons.
Thu Sep 01 00:00:00 UTC 2011
Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina.
The Journal of comparative neurology
Hilgen G,von Maltzahn J,Willecke K,Weiler R,Dedek K
A-6455 was used in immunohistochemistry to investigate the localization and function of Cx45 in OFF bipolar cells.
Tue Feb 15 00:00:00 UTC 2011
Identification of retinotectal projection pathway in the deep tectal laminae in the chick.
The Journal of comparative neurology
Omi M,Harada H,Nakamura H
A-6455 was used in immunohistochemistry to report a novel pathway of retinal fibers that run through deep laminae of the tectum.
Thu Sep 01 00:00:00 UTC 2011
Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier.
Endocrinology
Herde MK,Geist K,Campbell RE,Herbison AE
A-6455 was used in Immunohistochemistry to demonstrate that GnRH neurons extend complex, highly branched dendritic trees beyond the BBB into the OVLT, where they will be able to sense directly molecules circulating in the bloodstream.
Sat Oct 01 00:00:00 UTC 2011
Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cells.
BMC cell biology
Beach JR,Licate LS,Crish JF,Egelhoff TT
A-6455 was used in western blot to investigate the mechanism that regulates myosin II function in live cells.
Fri Dec 02 00:00:00 UTC 2011
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.
Nature communications
Léveillé N,Elkon R,Davalos V,Manoharan V,Hollingworth D,Oude Vrielink J,le Sage C,Melo CA,Horlings HM,Wesseling J,Ule J,Esteller M,Ramos A,Agami R
A-6455 was used in western blot to assess the role of RBM38 in p53 regulation.
Tue Oct 25 00:00:00 UTC 2011
Visualization of plant viral suppressor silencing activity in intact leaf lamina by quantitative fluorescent imaging.
Plant methods
Stephan D,Slabber C,George G,Ninov V,Francis KP,Burger JT
A-6455 was used in western blot to visualize plant viral suppressor silencing activity in intact leaf lamina.
Wed Aug 03 00:00:00 UTC 2011
Coe genes are expressed in differentiating neurons in the central nervous system of protostomes.
PloS one
Demilly A,Simionato E,Ohayon D,Kerner P,Garcès A,Vervoort M
A-6455 was used in immunohistochemistry to determine the role of coe genes during central nervous system development
Fri Oct 21 00:00:00 UTC 2011
Quantitative co-expression of proteins at the single cell level--application to a multimeric FRET sensor.
PloS one
Goedhart J,van Weeren L,Adjobo-Hermans MJ,Elzenaar I,Hink MA,Gadella TW
A-6455 was used in western blot to study co-expression of proteins.
Thu May 03 00:00:00 UTC 2012
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
Nature communications
Tatsumi K,Yamamoto-Mukai H,Shimizu R,Waguri S,Sou YS,Sakamoto A,Taya C,Shitara H,Hara T,Chung CH,Tanaka K,Yamamoto M,Komatsu M
A-6455 was used in western blot to elucidate the role of Uba5 in erythroid development.
Tue Feb 08 00:00:00 UTC 2011
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Cell
Hailey DW,Rambold AS,Satpute-Krishnan P,Mitra K,Sougrat R,Kim PK,Lippincott-Schwartz J
A-6455 was used in immunocytochemistry to report that the mitochondrial outer membrane participates in autophagosome biogenesis
Fri May 14 00:00:00 UTC 2010
Transgenic, inducible RNAi in megakaryocytes and platelets in mice.
Journal of thrombosis and haemostasis : JTH
Takiguchi M,James C,Josefsson EC,Carmichael CL,Premsrirut PK,Lowe SW,Hamilton JR,Huang DC,Kile BT,Dickins RA
A-6455 was used in flow cytometry to discuss inducible RNAi in mice.
Wed Dec 01 00:00:00 UTC 2010
A vacuolar glucoamylase, Sga1, participates in glycogen autophagy for proper asexual differentiation in Magnaporthe oryzae.
Autophagy
Deng YZ,Naqvi NI
A-6455 was used in western blot to explore how autophagy regulates glycogen homeostasis
Sat May 01 00:00:00 UTC 2010
A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels.
Proceedings of the National Academy of Sciences of the United States of America
Fergestad T,Sale H,Bostwick B,Schaffer A,Ho L,Robertson GA,Ganetzky B
A-6455 was used in immunohistochemistry to explore the role of Dao in membrane excitability
Tue Mar 23 00:00:00 UTC 2010
High-affinity manganese uptake by the metal transporter NRAMP1 is essential for Arabidopsis growth in low manganese conditions.
The Plant cell
Cailliatte R,Schikora A,Briat JF,Mari S,Curie C
A-6455 was used in western blot to investigate Mn uptake and transport in Arabidopsis thaliana
Mon Mar 01 00:00:00 UTC 2010
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
The Journal of cell biology
Matsuda N,Sato S,Shiba K,Okatsu K,Saisho K,Gautier CA,Sou YS,Saiki S,Kawajiri S,Sato F,Kimura M,Komatsu M,Hattori N,Tanaka K
A-6455 was used in immunoprecipitation to elucidate the relationship between Parkin-catalyzed ubiquitylation and PINK1-regulated mitochondrial quality control
Mon Apr 19 00:00:00 UTC 2010
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tolson KP,Gemelli T,Gautron L,Elmquist JK,Zinn AR,Kublaoui BM
A-6455 was used in immunohistochemistry to investigate the role of postnatal central nervous system deficiency of Sim1 in obesity
Wed Mar 10 00:00:00 UTC 2010
Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fuster JJ,González JM,Edo MD,Viana R,Boya P,Cervera J,Verges M,Rivera J,Andrés V
A-6455 was used in western blot to investigate proteasome-independent mechanisms of p27 proteolysis
Sun Aug 01 00:00:00 UTC 2010
Allogeneic stem cell transplantation does not improve neurological deficits in mucopolysaccharidosis type IIIA mice.
Experimental neurology
Lau AA,Hannouche H,Rozaklis T,Hassiotis S,Hopwood JJ,Hemsley KM
A-6455 was used in immunohistochemistry to assess the effectiveness of bone marrow transplantation in a murine model of mucopolysaccharidosis type IIIA
Fri Oct 01 00:00:00 UTC 2010
Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.
Journal of neurochemistry
Sulg M,Kirjavainen A,Pajusola K,Bueler H,Ylikoski J,Laiho M,Pirvola U
A-6455 was used in immunocytochemistry to study the response of auditory and balance hair cells to forced cell cycle reactivation and p53 up-regulation.
Mon Mar 01 00:00:00 UTC 2010
Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development.
Human molecular genetics
Polanco JC,Wilhelm D,Davidson TL,Knight D,Koopman P
A-6455 was used in immunohistochemistry to investigate the role of SOX10 in disorders of sex development
Mon Feb 01 00:00:00 UTC 2010
mTORC1 directly phosphorylates and regulates human MAF1.
Molecular and cellular biology
Michels AA,Robitaille AM,Buczynski-Ruchonnet D,Hodroj W,Reina JH,Hall MN,Hernandez N
A-6455 was used in western blot to elucidate mechanisms by which mTORC1 controls human MAF1
Sun Aug 01 00:00:00 UTC 2010
Expression of a glycosylated GFP as a bivalent reporter in exocytosis.
Plant cell reports
Paris N,Saint-Jean B,Faraco M,Krzeszowiec W,Dalessandro G,Neuhaus JM,Di Sansebastiano GP
A-6455 was used in western blot to study N-linked glycans of plants
Fri Jan 01 00:00:00 UTC 2010
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.
Journal of cellular biochemistry
Clark K,Howe JD,Pullar CE,Green JA,Artym VV,Yamada KM,Critchley DR
A-6455 was used in immunocytochemistry to investigate the role of tensins in cell-matrix remodeling
Mon Mar 01 00:00:00 UTC 2010
Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity.
Gene therapy
Woodard LE,Hillman RT,Keravala A,Lee S,Calos MP
A-6455 was used in immunohistochemistry - paraffin section to study how the cellular location and cell cycle affect phiC31 integrase activity
Mon Feb 01 00:00:00 UTC 2010
Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases.
Experimental cell research
Lin L,McCroskery S,Ross JM,Chak Y,Neuhuber B,Daniels MP
A-6455 was used in immunohistochemistry and western blot to assess the role of agrin's glycosaminoglycan chains in the induction of filopodia formation
Sun Aug 15 00:00:00 UTC 2010
Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis.
Cell transplantation
Mitrecić D,Nicaise C,Gajović S,Pochet R
A-6455 was used in immunohistochemistry - paraffin section to examine the effect of neural stem cell transplantation in a model of amyotrophic lateral sclerosis
Mon Nov 22 00:00:00 UTC 2010
Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.
Molecular biology of the cell
Tsuji T,Ohta Y,Kanno Y,Hirose K,Ohashi K,Mizuno K
A-6455 was used in western blot to identify which Rho-GEF family members are involved in Wnt/Dvl-induced RhoA activation in mammalian cells
Fri Oct 15 00:00:00 UTC 2010
Identification of the Tctex-1 regulatory element that directs expression to neural stem/progenitor cells in developing and adult brain.
The Journal of comparative neurology
Tseng YY,Gruzdeva N,Li A,Chuang JZ,Sung CH
A-6455 was used in immunohistochemistry to identify the regulatory elements in Tctex-1 involved in neurogenesis in developing and adult brain.
Sun Aug 15 00:00:00 UTC 2010
Cellular configuration of single octopamine neurons in Drosophila.
The Journal of comparative neurology
Busch S,Tanimoto H
A-6455 was used in immunohistochemistry to elucidate the developmental program that regulates the formation of the median octopamine cluster of the subesophageal ganglion.
Tue Jun 15 00:00:00 UTC 2010
Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits.
The Journal of comparative neurology
Carlsson MA,Diesner M,Schachtner J,Nässel DR
A-6455 was used in immunocytochemistry to analyze the expression of neuropeptides in the Drosophila antennal lobes.
Sun Aug 15 00:00:00 UTC 2010
Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells.
The Journal of comparative neurology
Enjin A,Rabe N,Nakanishi ST,Vallstedt A,Gezelius H,Memic F,Lind M,Hjalt T,Tourtellotte WG,Bruder C,Eichele G,Whelan PJ,Kullander K
A-6455 was used in immunohistochemistry to identify markers for fast motor neurons and partition cells.
Tue Jun 15 00:00:00 UTC 2010
The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis.
Cells, tissues, organs
Zizic Mitrecic M,Mitrecic D,Pochet R,Kostovic-Knezevic L,Gajovic S
A-6455 was used in immunohistochemistry to study the role of Noto in the tail bud during notochord formation
Mon Oct 04 00:00:00 UTC 2010
Exploration of self-renewal and pluripotency in ES cells using RNAi.
Methods in enzymology
Schaniel C,Lee DF,Lemischka IR
A-6455 was used in immunocytochemistry to describe high throughput methods to identify and validate genes that regulate mouse embryonic stem cell fate decisions
Fri Dec 10 00:00:00 UTC 2010
ISH-IEM: a sensitive method to detect endogenous mRNAs at the ultrastructural level.
Nature protocols
Herpers B,Xanthakis D,Rabouille C
A-6455 was used in Immunohistochemistry-immunofluorescence to describe the combination of in situ hybridization (ISH) with cryo-immunolabeling methods to allow the simultaneous detection at the ultrastructural level of mRNAs and proteins.
Thu Apr 01 00:00:00 UTC 2010
Recombinant Adeno-Associated Virus-Mediated microRNA Delivery into the Postnatal Mouse Brain Reveals a Role for miR-134 in Dendritogenesis in Vivo.
Frontiers in neural circuits
Christensen M,Larsen LA,Kauppinen S,Schratt G
A-6455 was used in immunohistochemistry to describe the construction and validation of a adeno-associated viral vector for the stable delivery of microRNAs in vivo
Thu Jul 14 00:00:00 UTC 2011
Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus.
Neuroscience
Irani BG,Donato J,Olson DP,Lowell BB,Sacktor TC,Reyland ME,Tolson KP,Zinn AR,Ueta Y,Sakata I,Zigman JM,Elias CF,Clegg DJ
A-6455 was used in Immunohistochemistry to show that PKC-θ and -δ are expressed in different hypothalamic neuronal populations.
Wed Nov 10 00:00:00 UTC 2010
Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of Tripeptidyl peptidase II.
Biochimica et biophysica acta
Villasevil EM,Guil S,López-Ferreras L,Sánchez C,Del Val M,Antón LC
A-6455 was used in immunocytochemistry to study proteasome-independent cytosolic protein degradation
Wed Sep 01 00:00:00 UTC 2010
The in vitro cleavage of the hAtg proteins by cell death proteases.
Autophagy
Norman JM,Cohen GM,Bampton ET
A-6455 was used in Western Blotting to show that the majority of human Atg (hAtg) proteins can be cleaved by calpain 1, which is activated in some apoptotic paradigms, as well as other forms of death.
Mon Nov 01 00:00:00 UTC 2010
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
Nature cell biology
van der Voet M,Berends CW,Perreault A,Nguyen-Ngoc T,Gönczy P,Vidal M,Boxem M,van den Heuvel S
A-6455 was used in immunohistochemistry to identify ASPM-1 as a LIN-5 binding partner
Sun Mar 01 00:00:00 UTC 2009
Involvement of Exo1b in DNA damage-induced apoptosis.
Nucleic acids research
Bolderson E,Richard DJ,Edelmann W,Khanna KK
A-6455 was used in western blot to study DNA damage-induced apoptosis and the involvement of Exo1b
Mon Jun 01 00:00:00 UTC 2009
Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction.
The Journal of cell biology
Merino C,Penney J,González M,Tsurudome K,Moujahidine M,O'Connor MB,Verheyen EM,Haghighi P
A-6455 was used in immunohistochemistry to report that Nemo kinase modulates bone morphogenic protein signaling in motor neurons
Mon May 18 00:00:00 UTC 2009
Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling.
Development (Cambridge, England)
Jülich D,Mould AP,Koper E,Holley SA
A-6455 was used in immunohistochemistry to investigate how integrin alpha5beta1 regulates extracellular matrix development
Tue Sep 01 00:00:00 UTC 2009
Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Eade KT,Allan DW
A-6455 was used in immunohistochemistry to determine the role of persistent BMP signaling in the maintenance of Tv phenotype
Wed Mar 25 00:00:00 UTC 2009
Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ernst MB,Wunderlich CM,Hess S,Paehler M,Mesaros A,Koralov SB,Kleinridders A,Husch A,Münzberg H,Hampel B,Alber J,Kloppenburg P,Brüning JC,Wunderlich FT
A-6455 was used in immunohistochemistry - free floating to characterize mice expressing a constitutively active version of Stat3 in proopiomelanocortin neurons
Wed Sep 16 00:00:00 UTC 2009
Live imaging reveals that the Drosophila actin-binding ERM protein, moesin, co-localizes with the mitotic spindle.
European journal of cell biology
Vilmos P,Jankovics F,Szathmári M,Lukácsovich T,Henn L,Erdélyi M
A-6455 was used in immunohistochemistry to observe the cellular localization of moesin
Thu Oct 01 00:00:00 UTC 2009
Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells.
American journal of physiology. Cell physiology
Matsuoka H,Harada K,Ikeda T,Uetsuki K,Sata T,Warashina A,Inoue M
A-6455 was used in immunocytochemistry and western blot to determine if rat adrenal medullary cells have store-operated calcium channels
Wed Apr 01 00:00:00 UTC 2009
Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases.
Journal of cell science
Tifft KE,Bradbury KA,Wilson KL
A-6455 was used in immunoprecipitation to investigate phosphatases that regulate emerin function
Thu Oct 15 00:00:00 UTC 2009
FoxA1 binding directs chromatin structure and the functional response of a glucocorticoid receptor-regulated promoter.
Molecular and cellular biology
Belikov S,Astrand C,Wrange O
A-6455 was used in EMSA to investigate GR and FoxA1-mediated transcription
Thu Oct 01 00:00:00 UTC 2009
Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.
Gene therapy
McCarty DM,DiRosario J,Gulaid K,Muenzer J,Fu H
A-6455 was used in immunohistochemistry to optimize central nervous system transduction in mice by mannitol-facilitated entry of intravenous-delivered recombinant adeno-associated viral serotype 2 vector
Sun Nov 01 00:00:00 UTC 2009
Expression analysis of green fluorescent protein in retinal neurons of four transgenic mouse lines.
Neuroscience
Haverkamp S,Inta D,Monyer H,Wässle H
A-6455 was used in immunocytochemistry to characterize the retinas of four EGFP-expressing mouse lines
Tue Apr 21 00:00:00 UTC 2009
A novel type of interplexiform amacrine cell in the mouse retina.
The European journal of neuroscience
Dedek K,Breuninger T,de Sevilla Müller LP,Maxeiner S,Schultz K,Janssen-Bienhold U,Willecke K,Euler T,Weiler R
A-6455 was used in immunohistochemistry - frozen section to characterize a new interplexiform amacrine cell type in the mouse retina
Wed Jul 01 00:00:00 UTC 2009
A map of octopaminergic neurons in the Drosophila brain.
The Journal of comparative neurology
Busch S,Selcho M,Ito K,Tanimoto H
A-6455 was used in immunohistochemistry to report a comprehensive anatomical map of candidate octopaminergic neurons in the adult Drosophila brain.
Mon Apr 20 00:00:00 UTC 2009
Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus.
Epilepsy research
Raedt R,Van Dycke A,Waeytens A,Wyckhuys T,Vonck K,Wadman W,Boon P
A-6455 was used in immunohistochemistry - free floating to determine the fate of adult-derived neurosphere cells after transplantation in a model for temporal lobe epilepsy
Tue Dec 01 00:00:00 UTC 2009
Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure.
The Journal of membrane biology
Li HC,Collier JH,Shawki A,Rudra JS,Li EY,Mackenzie B,Soleimani M
A-6455 was used in immunocytochemistry and western blot to characterize the dihydrophobic FL motif of NBC1
Sun Mar 01 00:00:00 UTC 2009
Establishment of the long-term in vitro culture system for chicken primordial germ cells.
Reproduction in domestic animals = Zuchthygiene
Shiue YL,Tailiu JJ,Liou JF,Lu HT,Tai C,Shiau JW,Chen LR
A-6455 was used in immunocytochemistry to develop a long-term in vitro culturing system for chicken gonadal primordial germ cells
Sun Feb 01 00:00:00 UTC 2009
Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models.
Methods in enzymology
Chu CT,Plowey ED,Dagda RK,Hickey RW,Cherra SJ,Clark RS
A-6455 was used in western blot to analyze autophagy in neurodegeneration and neurite injury utilizing in vivo and in vitro models
Thu Apr 02 00:00:00 UTC 2009
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
PloS one
Montes de Oca R,Shoemaker CJ,Gucek M,Cole RN,Wilson KL
A-6455 was used in immunoprecipitation to identify proteins that interact with barrier-to-autointegration factor
Wed Sep 16 00:00:00 UTC 2009
Leptin targets in the mouse brain.
The Journal of comparative neurology
Scott MM,Lachey JL,Sternson SM,Lee CE,Elias CF,Friedman JM,Elmquist JK
A-6455 was used in Immunohistochemistry to systematically characterise LepRb distribution in the mouse brain and EYFP immunoreactivity in a novel LepRb-IRES-Cre EYFP reporter mouse line.
Wed Jun 10 00:00:00 UTC 2009
Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord.
Methods in molecular biology (Clifton, N.J.)
Wichterle H,Peljto M,Nedelec S
A-6455 was used in immunohistochemistry to describe xenotransplantation of mouse embryonic stem cell-derived motor neurons into the developing chick neural tube to study the functional incorporation of embryonic stem cells into a neural network
Wed Feb 11 00:00:00 UTC 2009
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint.
Nature genetics
Owusu-Ansah E,Yavari A,Mandal S,Banerjee U
A-6455 was used in immunohistochemistry to study the control of the G1-S cell cycle checkpoint due to distinct mitochondrial retrograde signals
Sat Mar 01 00:00:00 UTC 2008
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.
Nature cell biology
Johansson CB,Youssef S,Koleckar K,Holbrook C,Doyonnas R,Corbel SY,Steinman L,Rossi FM,Blau HM
A-6455 was used in immunohistochemistry - free floating to study the response to chronic inflammation and the extensive fusion of haemotopoietic cells with Purkinje neurons
Thu May 01 00:00:00 UTC 2008
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease.
Autophagy
Dagda RK,Zhu J,Kulich SM,Chu CT
A-6455 was used in western blot to assess regulation of autophagic and mitophagy cell stress due to mitochondrially localized ERK2 and implications in Parkinson's disease
Fri Aug 01 00:00:00 UTC 2008
Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase.
Molecular therapy : the journal of the American Society of Gene Therapy
Stachler MD,Chen I,Ting AY,Bartlett JS
A-6455 was used in immunohistochemistry - frozen section to study site-specific modification of AAV vector particles with targeting ligands and biophysical probes using biotin ligase
Fri Aug 01 00:00:00 UTC 2008
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.
The Journal of cell biology
Axe EL,Walker SA,Manifava M,Chandra P,Roderick HL,Habermann A,Griffiths G,Ktistakis NT
A-6455 was used in immunocytochemistry and western blot to study membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum during autophagosome formation
Mon Aug 25 00:00:00 UTC 2008
Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shim SY,Wang J,Asada N,Neumayer G,Tran HC,Ishiguro K,Sanada K,Nakatani Y,Nguyen MD
A-6455 was used in immunocytochemistry to investigate the role of protein 600 in neurons
Wed Apr 02 00:00:00 UTC 2008
Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dhaka A,Earley TJ,Watson J,Patapoutian A
A-6455 was used in immunohistochemistry to visualize cold spots by studying TRPM8-expressing sensory neurons and their projections
Wed Jan 16 00:00:00 UTC 2008
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.
American journal of physiology. Cell physiology
Nunes P,Hasler U,McKee M,Lu HA,Bouley R,Brown D
A-6455 was used in immunocytochemistry and western blot to study vasopressin-induced exocytosis in native and aquaporin-2-expressing renal LLC-PK(1) cells
Mon Dec 01 00:00:00 UTC 2008
Esterification of cholesterol by a type III secretion effector during intracellular Salmonella infection.
Molecular microbiology
Nawabi P,Catron DM,Haldar K
A-6455 was used in immunocytochemistry to examine how the Salmonella pathogenicity island 2 effector, SseJ, affects cholesterol
Tue Apr 01 00:00:00 UTC 2008
Human calpain 7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments.
Journal of biochemistry
Yorikawa C,Takaya E,Osako Y,Tanaka R,Terasawa Y,Hamakubo T,Mochizuki Y,Iwanari H,Kodama T,Maeda T,Hitomi K,Shibata H,Maki M
A-6455 was used in immunoprecipitation to identify proteins that interact with calpain 7
Sun Jun 01 00:00:00 UTC 2008
Identification of major classes of cholinergic neurons in the nematode Caenorhabditis elegans.
The Journal of comparative neurology
Duerr JS,Han HP,Fields SD,Rand JB
A-6455 was used in immunocytochemistry to determine the subcellular and cellular distributions of ChAT and VAChT.
Sun Jan 20 00:00:00 UTC 2008
Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons.
The Journal of comparative neurology
Thorne N,Amrein H
A-6455 was used in immunocytochemistry to characterize the expression of six highly conserved gustatory receptor genes.
Fri Feb 01 00:00:00 UTC 2008
Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice.
Journal of neuroscience methods
Basu K,Gravel C,Tomioka R,Kaneko T,Tamamaki N,Sík A
A-6455 was used in immunocytochemistry to characterize a novel process for selectively labeling inhibitory and excitatory neurons in the cerebral cortex of mice
Fri May 30 00:00:00 UTC 2008
Efficient production of monoclonal antibodies recognizing specific structures in Caenorhabditis elegans embryos using an antigen subtraction method.
Genes to cells : devoted to molecular & cellular mechanisms
Takeda K,Watanabe C,Qadota H,Hanazawa M,Sugimoto A
A-6455 was used in immunohistochemistry to describe a method for antigen subtraction
Tue Jul 01 00:00:00 UTC 2008
SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail.
Cell cycle (Georgetown, Tex.)
Yin Y,Yu VC,Zhu G,Chang DC
A-6455 was used in immunoprecipitation to elucidate how SET8 regulates the cell cycle
Thu May 15 00:00:00 UTC 2008
Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.
Molecular endocrinology (Baltimore, Md.)
Stöckli J,Davey JR,Hohnen-Behrens C,Xu A,James DE,Ramm G
A-6455 was used in flow cytometry and immunocytochemistry to identify factors that regulation insulin-stimulated GLUT4 translocation
Mon Dec 01 00:00:00 UTC 2008
Tomato Rab11a characterization evidenced a difference between SYP121-dependent and SYP122-dependent exocytosis.
Plant & cell physiology
Rehman RU,Stigliano E,Lycett GW,Sticher L,Sbano F,Faraco M,Dalessandro G,Di Sansebastiano GP
A-6455 was used in Western Blot to suggest that Rab11 regulates anterograde transport from the TGN to the plasma membrane and strongly implicate SYP122, rather than SYP121.
Thu May 01 00:00:00 UTC 2008
Identification of endogenously presented peptides from Chlamydia trachomatis with high homology to human proteins and to a natural self-ligand of HLA-B27.
Molecular & cellular proteomics : MCP
Cragnolini JJ,de Castro JA
A-6455 was used in immunoprecipitation and western blot to identify Chlamydia trachomatis epitopes that are endogenously processed and presented by HLA-B27
Tue Jan 01 00:00:00 UTC 2008
Electroporation strategies for genetic manipulation and cell labeling.
Methods in molecular biology (Clifton, N.J.)
Van Raay TJ,Lassiter RT,Stark MR
A-6455 was used in Immunocytochemistry to provide protocols for the application of in ovo chick electroporation and in vitro targeting of neuroepithelial precursor cells.
Thu Apr 17 00:00:00 UTC 2008
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.
Molecular endocrinology (Baltimore, Md.)
Kublaoui BM,Gemelli T,Tolson KP,Wang Y,Zinn AR
A-6455 was used in immunohistochemistry to test if altered paraventricular nucleus neuropeptide expression mediates the hyperphagia of Sim1 heterozygous mice
Tue Jul 01 00:00:00 UTC 2008
An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells.
Nature
Teh OK,Moore I
A-6455 was used in western blot to study selective endocytosis and an ARF-GEF acting at the Golgi in polarized plant cells
Thu Jul 26 00:00:00 UTC 2007
Dlx transcription factors promote migration through repression of axon and dendrite growth.
Neuron
Cobos I,Borello U,Rubenstein JL
A-6455 was used in immunohistochemistry - frozen section to assess promotion of migration through repression of dendrite and axon growth by Dlx transcription factors
Thu Jun 21 00:00:00 UTC 2007
Unfolded protein response in a Drosophila model for retinal degeneration.
The EMBO journal
Ryoo HD,Domingos PM,Kang MJ,Steller H
A-6455 was used in immunohistochemistry and western blot to examine the role of xbp1 in neurodegenerative diseases
Wed Jan 10 00:00:00 UTC 2007
Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies.
Developmental cell
Delanoue R,Herpers B,Soetaert J,Davis I,Rabouille C
A-6455 was used in immunohistochemistry to study the switch of Dynein from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies in Drosophila Squid/hnRNP
Mon Oct 01 00:00:00 UTC 2007
Stable gene transfer to muscle using non-integrating lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy
Apolonia L,Waddington SN,Fernandes C,Ward NJ,Bouma G,Blundell MP,Thrasher AJ,Collins MK,Philpott NJ
A-6455 was used in immunohistochemistry - paraffin section to develop and characterize non-integrating lentiviral vectors for gene transfer and expression in muscle in vivo
Thu Nov 01 00:00:00 UTC 2007
Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling.
Proceedings of the National Academy of Sciences of the United States of America
Tuluc P,Kern G,Obermair GJ,Flucher BE
A-6455 was used in immunocytochemistry to study an indication of an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling by computer modeling of siRNA knockdown
Tue Jun 26 00:00:00 UTC 2007
v-SNARE cellubrevin is required for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells.
The Journal of cell biology
Fields IC,Shteyn E,Pypaert M,Proux-Gillardeaux V,Kang RS,Galli T,Fölsch H
A-6455 was used to assess requirement for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells by v-SNARE cellubrevin
Mon May 07 00:00:00 UTC 2007
The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
Development (Cambridge, England)
Nelson SB,Schaffer AE,Sander M
A-6455 was used in immunohistochemistry to investigate how Nkx6.1 and Nkx6.2 orchestrate the development of the endocrine alpha- and beta-cell lineages
Sun Jul 01 00:00:00 UTC 2007
PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shalizi A,Bilimoria PM,Stegmüller J,Gaudillière B,Yang Y,Shuai K,Bonni A
A-6455 was used in immunocytochemistry to identify PIASx as a MEF2 SUMO E3 ligase that represses MEF2-dependent transcription in neurons
Wed Sep 12 00:00:00 UTC 2007
Multiple memory traces for olfactory reward learning in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Thum AS,Jenett A,Ito K,Heisenberg M,Tanimoto H
A-6455 was used in immunohistochemistry to study cells that regulate appetitive learning in Drosophila melanogaster
Wed Oct 10 00:00:00 UTC 2007
In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kim EJ,Leung CT,Reed RR,Johnson JE
A-6455 was used in immunohistochemistry - free floating to report that Ascl1 is a molecular marker of early progenitors of neurons and oligodendrocytes
Wed Nov 21 00:00:00 UTC 2007
Auditory neurons make stereotyped wiring decisions before maturation of their targets.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koundakjian EJ,Appler JL,Goodrich LV
A-6455 was used in immunohistochemistry - free floating to observe the morphologies of individual cochlear ganglion neurons throughout development
Wed Dec 19 00:00:00 UTC 2007
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.
Journal of virology
Baker A,Rohleder KJ,Hanakahi LA,Ketner G
A-6455 was used in western blot to study the role of Adenovirus E4 34k and E1b 55k oncoproteins in targeting host DNA ligase IV for proteasomal degradation
Sun Jul 01 00:00:00 UTC 2007
Chronic exposure to sub-lethal beta-amyloid (Abeta) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells.
Journal of neurochemistry
Sirk D,Zhu Z,Wadia JS,Shulyakova N,Phan N,Fong J,Mills LR
A-6455 was used in immunoprecipitation to investigate the influence of Abeta on protein transport from nucleus to mitochondira.
Sat Dec 01 00:00:00 UTC 2007
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn.
The Journal of pharmacology and experimental therapeutics
Garraway SM,Xu Q,Inturrisi CE
A-6455 was used in immunohistochemistry to test if vector-derived siRNAs can reduce the expression of the NR1 subunit of the N-methyl-D-aspartate receptor
Sat Sep 01 00:00:00 UTC 2007
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.
Molecular biology of the cell
Li X,Kaloyanova D,van Eijk M,Eerland R,van der Goot G,Oorschot V,Klumperman J,Lottspeich F,Starkuviene V,Wieland FT,Helms JB
A-6455 was used in immunocytochemistry to characterize Golgi-resident GPI-anchored protein (GREG)
Sun Apr 01 00:00:00 UTC 2007
Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6.
Developmental biology
Guidato S,Itasaki N
A-6455 was used in western blot to describe a cellular mechanism for the action of Wise
Mon Oct 15 00:00:00 UTC 2007
Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved.
The Journal of comparative neurology
Pineau I,Lacroix S
A-6455 was used in immunocytochemistry to determine the spatial and temporal distribution of proinflammatory cytokines and identified their cellular source in a clinically relevant model of spinal cord injury.
Wed Jan 10 00:00:00 UTC 2007
Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila: distinct classes of hugin-expressing neurons.
The Journal of comparative neurology
Bader R,Colomb J,Pankratz B,Schröck A,Stocker RF,Pankratz MJ
A-6455 was used in immunohistochemistry to assess the morphology of the hugin neurons at a single-cell level by using clonal analysis.
Sun Jun 10 00:00:00 UTC 2007
Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain.
Journal of neuroscience methods
Franciosi S,De Gasperi R,Dickstein DL,English DF,Rocher AB,Janssen WG,Christoffel D,Sosa MA,Hof PR,Buxbaum JD,Elder GA
A-6455 was used in immunohistochemistry - free floating to assess the allowing of collagen IV immunostaining of blood vessels in adult mouse brain by pepsin pretreatment
Fri Jun 15 00:00:00 UTC 2007
Glycine receptors of A-type ganglion cells of the mouse retina.
Visual neuroscience
Majumdar S,Heinze L,Haverkamp S,Ivanova E,Wässle H
A-6455 was used in immunocytochemistry to examine the glycinergic, inhibitory input of A-type ganglion cells
Tue Nov 20 00:00:00 UTC 2007
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord.
Development (Cambridge, England)
Battiste J,Helms AW,Kim EJ,Savage TK,Lagace DC,Mandyam CD,Eisch AJ,Miyoshi G,Johnson JE
A-6455 was used in Immunohistochemistry to demonstrate that sequentially generated Ascl1-expressing progenitors give rise first to dorsal horn interneurons and subsequently to late-born oligodendrocytes.
Mon Jan 01 00:00:00 UTC 2007
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila.
PLoS genetics
Bilen J,Bonini NM
A-6455 was used in immunohistochemistry to identify and characterize modifiers of Ataxin-3-induced neurodegeneration
Mon Oct 01 00:00:00 UTC 2007
Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections.
Methods in molecular biology (Clifton, N.J.)
Seymour PA,Sander M
A-6455 was used in immunohistochemistry - frozen section to study the fate of specific cell types in vivo during development and adulthood in mice
Thu Jun 05 00:00:00 UTC 2008
Evidence that stem cells reside in the adult Drosophila midgut epithelium.
Nature
Micchelli CA,Perrimon N
A-6455 was used in immunohistochemistry to learn about adult Drosophila midgut epithelium and evidence of residing stem cells
Thu Jan 26 00:00:00 UTC 2006
Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment.
Proceedings of the National Academy of Sciences of the United States of America
Kulesa PM,Kasemeier-Kulesa JC,Teddy JM,Margaryan NV,Seftor EA,Seftor RE,Hendrix MJ
A-6455 was used in immunohistochemistry to analyze reprogramming to assume a neural crest cell-like phenotype in an embryonic microenvironment in metastatic melanoma cells
Tue Mar 07 00:00:00 UTC 2006
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America
Liao G,Tao Q,Kofron M,Chen JS,Schloemer A,Davis RJ,Hsieh JC,Wylie C,Heasman J,Kuan CY
A-6455 was used in immunoprecipitation and western blot to study prevention of nuclear beta-catenin accumulation and regulation of axis formation in Xenopus embryos by Jun NH2-terminal kinase (JNK)
Tue Oct 31 00:00:00 UTC 2006
The Salmonella effector protein PipB2 is a linker for kinesin-1.
Proceedings of the National Academy of Sciences of the United States of America
Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S
A-6455 was used in immunoprecipitation and western blot to study a linker for kinesin-1 called salmonella effector protein PipB2
Tue Sep 05 00:00:00 UTC 2006
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America
Rowe DC,McGettrick AF,Latz E,Monks BG,Gay NJ,Yamamoto M,Akira S,O'Neill LA,Fitzgerald KA,Golenbock DT
A-6455 was used in immunoprecipitation and western blot to study the need for Toll-like receptor 4 signal transduction by myristoylation of TRIF-related adaptor molecule
Tue Apr 18 00:00:00 UTC 2006
A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking.
Proceedings of the National Academy of Sciences of the United States of America
Awai K,Xu C,Tamot B,Benning C
A-6455 was used in western blot to characterize lipid trafficking and a phosphatidic acid-binding protein of the chloroplast inner envelope membrane
Tue Jul 11 00:00:00 UTC 2006
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America
Lee KW,Kim Y,Kim AM,Helmin K,Nairn AC,Greengard P
A-6455 was used in immunohistochemistry - frozen section to study the formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens by cocaine-induced dendritic spine formation
Tue Feb 28 00:00:00 UTC 2006
Erythrocyte G protein as a novel target for malarial chemotherapy.
PLoS medicine
Murphy SC,Harrison T,Hamm HE,Lomasney JW,Mohandas N,Haldar K
A-6455 was used in immunocytochemistry to discuss inhibiting erythrocyte Gs signaling to inhibit invasion by Plasmodium falciparum
Fri Dec 01 00:00:00 UTC 2006
Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly.
The Journal of cell biology
Chen X,Macara IG
A-6455 was used in immunocytochemistry and immunoprecipitation to assess inhibition of LIM kinase 2 to regulate tight junction assembly and cofilin phosphorylation by Par-3
Mon Feb 27 00:00:00 UTC 2006
A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling.
The Journal of cell biology
Dantuma NP,Groothuis TA,Salomons FA,Neefjes J
A-6455 was used in western blot to study the coupling of chromatin remodeling to proteasomal activity by a dynamic ubiquitin equilibrium
Mon Apr 10 00:00:00 UTC 2006
A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells.
The Journal of cell biology
Cooke BM,Buckingham DW,Glenister FK,Fernandez KM,Bannister LH,Marti M,Mohandas N,Coppel RL
A-6455 was used in immunocytochemistry to study the expression of the major malaria virulence antigen on the surface of infected red blood cells that requires a Maurer's cleft-associated protein
Mon Mar 13 00:00:00 UTC 2006
Asynchronous nuclear division cycles in multinucleated cells.
The Journal of cell biology
Gladfelter AS,Hungerbuehler AK,Philippsen P
A-6455 was used in immunocytochemistry to elucidate multinucleated cells and asynchronous nuclear division cycles
Mon Jan 30 00:00:00 UTC 2006
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix.
Development (Cambridge, England)
Callejo A,Torroja C,Quijada L,Guerrero I
A-6455 was used in immunohistochemistry and western blot to study the localization and interactions of lipid-modified hedgehog
Wed Feb 01 00:00:00 UTC 2006
Cloning and expression of deoxyribonuclease II from chicken.
Gene
MacLea KS,Cheng HH
A-6455 was used in western blot to report the cloning and expression of DNase II from the chicken
Wed May 24 00:00:00 UTC 2006
Fluorescent tagged analysis of neural gene function using mosaics in zebrafish and Xenopus laevis.
Brain research
Conway G,Torrejón M,Lin S,Reinsch S
A-6455 was used in immunohistochemistry to develop a method to label neuronal subsets in zebrafish and Xenopus laevis
Fri Jan 27 00:00:00 UTC 2006
STAT3-dependent pathfinding and control of axonal branching and target selection.
Developmental biology
Conway G
A-6455 was used in immunohistochemistry determine the role of STAT3 in neuronal guidance
Tue Aug 01 00:00:00 UTC 2006
Cells in the vomeronasal organ express odorant receptors but project to the accessory olfactory bulb.
The Journal of comparative neurology
Lévai O,Feistel T,Breer H,Strotmann J
A-6455 was used in immunohistochemistry to investigate the expression of odorant receptors in the vomeronasal organ express and its projection to the accessory olfactory bulb
Sun Oct 01 00:00:00 UTC 2006
Fate of endogenous stem/progenitor cells following spinal cord injury.
The Journal of comparative neurology
Horky LL,Galimi F,Gage FH,Horner PJ
A-6455 was used in immunohistochemistry to investigate endogenous stem/progenitor cells after spinal cord injury.
Sun Oct 01 00:00:00 UTC 2006
Differential potencies of effector genes in adult Drosophila.
The Journal of comparative neurology
Thum AS,Knapek S,Rister J,Dierichs-Schmitt E,Heisenberg M,Tanimoto H
A-6455 was used in immunohistochemistry to show differences in the action of the five effector genes shibire, Tetanus toxin light chain, reaper, Diphtheria toxin A-chain, and inwardly rectifying potassium channel.
Sun Sep 10 00:00:00 UTC 2006
The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing.
The Journal of biological chemistry
Léonard R,Rendic D,Rabouille C,Wilson IB,Préat T,Altmann F
A-6455 was used in immunocytochemistry to study encoding of an N-acetylglucosaminidase involved in N-glycan processing in the Drosophila fused lobes gene
Fri Feb 24 00:00:00 UTC 2006
Cellular uptake of exogenous human PDCD5 protein.
The Journal of biological chemistry
Wang Y,Li D,Fan H,Tian L,Zhong Y,Zhang Y,Yuan L,Jin C,Yin C,Ma D
A-6455 was used in immunocytochemistry to study exogenous human PDCD5 protein and cellular uptake
Fri Aug 25 00:00:00 UTC 2006
A novel experimental platform for investigating cancer growth and anti-cancer therapy in a human tissue microenvironment derived from human embryonic stem cells.
Methods in molecular biology (Clifton, N.J.)
Tzukerman M,Skorecki KL
A-6455 was used in immunohistochemistry - paraffin section to test if human cancer cells grow within teratomas in immune compromised mice
Thu Aug 24 00:00:00 UTC 2006
Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.
The Journal of biological chemistry
Pérez-Victoria FJ,Sánchez-Cañete MP,Castanys S,Gamarro F
A-6455 was used in western blot to study the requirement of L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites due to phospholipid translocation and miltefosine potency
Fri Aug 18 00:00:00 UTC 2006
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.
The Journal of biological chemistry
Takahashi Y,Dominici M,Swift J,Nagy C,Ihle JN
A-6455 was used in immunohistochemistry - paraffin section to study the rescue of placental defect in SOCS3-deficient mice due to trophoblast stem cells
Fri Apr 28 00:00:00 UTC 2006
Blockade of NFAT activation by the second calcineurin binding site.
The Journal of biological chemistry
Martínez-Martínez S,Rodríguez A,López-Maderuelo MD,Ortega-Pérez I,Vázquez J,Redondo JM
A-6455 was used in western blot to assess the second calcineurin binding site by blockade of NFAT activation
Fri Mar 10 00:00:00 UTC 2006
A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining.
Nature protocols
Wu JS,Luo L
A-6455 was used in immunohistochemistry - paraffin section to describe a basic method for dissection and immunofluorescence staining of the Drosophila brain at various developmental stages
Tue Oct 30 00:00:00 UTC 2007
Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies.
The Journal of biological chemistry
Jang LT,Buu LM,Lee FJ
A-6455 was used in immunocytochemistry to study determinants of Rbp1p localization called P-bodies in specific cytoplasmic mRNA-processing foci
Fri Sep 29 00:00:00 UTC 2006
Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells.
The Journal of biological chemistry
Jiang Y,Oliver P,Davies KE,Platt N
A-6455 was used in western blot to analyze and identify a novel class A scavenger receptor that is expressed by populations of epithelial cells called murine SCARA5
Fri Apr 28 00:00:00 UTC 2006
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.
Molecular endocrinology (Baltimore, Md.)
Kublaoui BM,Holder JL,Gemelli T,Zinn AR
A-6455 was used in immunohistochemistry to report that Sim1 heterozygote mice are resistant to hypothalamic melanocortin signaling
Sun Oct 01 00:00:00 UTC 2006
A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila.
Nature protocols
Wu JS,Luo L
A-6455 was used in immunocytochemistry to discuss the uses of mosaic analysis with a repressible cell marker (MARCM)
Mon Nov 05 00:00:00 UTC 2007
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.
The Journal of biological chemistry
Miller S,Sparacio S,Bartenschlager R
A-6455 was used in immunocytochemistry and western blot to characterize the Dengue virus type 2 non-structural protein 4B and its membrane topology and subcellular localization
Fri Mar 31 00:00:00 UTC 2006
Stem cell division is regulated by the microRNA pathway.
Nature
Hatfield SD,Shcherbata HR,Fischer KA,Nakahara K,Carthew RW,Ruohola-Baker H
A-6455 was used in immunohistochemistry to study the regulation by the microRNA pathway due to stem cell division
Thu Jun 16 00:00:00 UTC 2005
GPCR signaling is required for blood-brain barrier formation in drosophila.
Cell
Schwabe T,Bainton RJ,Fetter RD,Heberlein U,Gaul U
A-6455 was used in immunohistochemistry to study the requirement for blood-brain barrier formation in drosophila by GPCR signaling
Fri Oct 07 00:00:00 UTC 2005
Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons.
Neuron
Karpova AY,Tervo DG,Gray NW,Svoboda K
A-6455 was used in immunohistochemistry to analyze synaptic transmission in genetically targeted neurons by rapid and reversible chemical inactivation
Thu Dec 08 00:00:00 UTC 2005
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Goldstein AY,Jan YN,Luo L
A-6455 was used in immunohistochemistry to report that Tumbleweed, Pavarotti, and their association are required for neuroblast proliferation in Drosophila
Tue Mar 08 00:00:00 UTC 2005
A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.
Molecular and cellular biology
Kamada S,Kikkawa U,Tsujimoto Y,Hunter T
A-6455 was used in immunoprecipitation and western blot to identify A-kinase-anchoring protein 95 as a caspase 3-binding protein
Tue Nov 01 00:00:00 UTC 2005
The polycomb group gene product Mel-18 interacts with cyclin D2 and modulates its activity.
FEBS letters
Chun T,Rho SB,Byun HJ,Lee JY,Kong G
A-6455 was used in immunoprecipitation to report that Mel-18 directly interacts with cyclin D2
Mon Oct 10 00:00:00 UTC 2005
Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Molecular biology of the cell
Bimbó A,Liu J,Balasubramanian MK
A-6455 was used in immunocytochemistry to elucidate the effects of Pdk1p on cytokinesis
Fri Jul 01 00:00:00 UTC 2005
Functional display of an alpha2 integrin-specific motif (RKK) on the surface of baculovirus particles.
Technology in cancer research & treatment
Riikonen R,Matilainen H,Rajala N,Pentikainen O,Johnson M,Heino J,Oker-Blom C
A-6455 was used in western blot to characterize viruses that express an alpha2beta1 integrin-specific loop
Mon Aug 01 00:00:00 UTC 2005
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
The Journal of biological chemistry
Young DB,Jonnalagadda J,Gatei M,Jans DA,Meyn S,Khanna KK
A-6455 was used in Western Blot to indicate that the amino terminus of ATM is crucial not only for nuclear localization but also for chromatin association, thereby facilitating the kinase activity of ATM in vivo.
Fri Jul 29 00:00:00 UTC 2005
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.
The Journal of biological chemistry
Martin S,Driessen K,Nixon SJ,Zerial M,Parton RG
A-6455 was used in immunocytochemistry and western blot to analyze regulation of localized Rab18 to lipid droplets and the effects of lipolytic stimulation and inhibition of lipid droplet catabolism
Fri Dec 23 00:00:00 UTC 2005
Nanotubular highways for intercellular organelle transport.
Science (New York, N.Y.)
Rustom A,Saffrich R,Markovic I,Walther P,Gerdes HH
A-6455 was used in immunocytochemistry to determine intercellular organelle transport by nanotubular highways
Fri Feb 13 00:00:00 UTC 2004
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood
Waddington SN,Nivsarkar MS,Mistry AR,Buckley SM,Kemball-Cook G,Mosley KL,Mitrophanous K,Radcliffe P,Holder MV,Brittan M,Georgiadis A,Al-Allaf F,Bigger BW,Gregory LG,Cook HT,Ali RR,Thrasher A,Tuddenham EG,Themis M,Coutelle C
A-6455 was used in immunohistochemistry - paraffin section to report the permanent therapeutic correction of Christmas disease using an HIV-based lentiviral vector encoding the human factor IX protein
Mon Nov 01 00:00:00 UTC 2004
The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.
Developmental cell
Trautmann S,Rajagopalan S,McCollum D
A-6455 was used in immunocytochemistry and western blot to report that Clp1p/Flp1p localizes to kinetochores in prometaphase and functions in chromosome segregation
Mon Nov 01 00:00:00 UTC 2004
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors.
Proceedings of the National Academy of Sciences of the United States of America
Sekine-Aizawa Y,Huganir RL
A-6455 was used in immunocytochemistry to utilize alpha-bungarotoxin-binding-site-tagged receptors for imaging of receptor trafficking
Tue Dec 07 00:00:00 UTC 2004
Taste perception and coding in Drosophila.
Current biology : CB
Thorne N,Chromey C,Bray S,Amrein H
A-6455 was used in immunohistochemistry to discuss the properties of gustatory receptors
Tue Jun 22 00:00:00 UTC 2004
Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.
The Journal of cell biology
Lechardeur D,Xu M,Lukacs GL
A-6455 was used in western blot to study apoptotic and dividing cells to view contrasting nuclear dynamics of the caspase-activated Dnase (CAD)
Mon Dec 06 00:00:00 UTC 2004
A GFP-based assay reveals a role for RHD3 in transport between the endoplasmic reticulum and Golgi apparatus.
The Plant journal : for cell and molecular biology
Zheng H,Kunst L,Hawes C,Moore I
A-6455 was used in western blot to identify a role for root hair defective 3 in transport of secreted and Golgi markers between the ER and the Golgi apparatus
Sun Feb 01 00:00:00 UTC 2004
Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction.
Development (Cambridge, England)
Torroja C,Gorfinkiel N,Guerrero I
A-6455 was used in immunohistochemistry and western blot to elucidate how endocytosis regulates the concentration and activity of Hedgehog in the wing imaginal disc
Sat May 01 00:00:00 UTC 2004
Mechanisms of HP1-mediated gene silencing in Drosophila.
Development (Cambridge, England)
Danzer JR,Wallrath LL
A-6455 was used in ChIP assay to elucidate mechanisms of silent chromatin formation and spreading
Sun Aug 01 00:00:00 UTC 2004
An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Senut MC,Gulati-Leekha A,Goldman D
A-6455 was used in immunohistochemistry - frozen section to study the requirement for retinal expression during optic nerve regeneration by an element in the alpha1-tubulin promoter and not after eye injury in the adult zebrafish
Wed Sep 01 00:00:00 UTC 2004
Sister chromatid separation at human telomeric regions.
Journal of cell science
Yalon M,Gal S,Segev Y,Selig S,Skorecki KL
A-6455 was used in immunocytochemistry to suggest that telomeric regions may be sites of persistent cohesion in animal cells
Thu Apr 15 00:00:00 UTC 2004
The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe.
Journal of cell science
Mishra M,Karagiannis J,Trautmann S,Wang H,McCollum D,Balasubramanian MK
A-6455 was used in immunocytochemistry to investigate the Clp1p/Flp1p-dependent cytokinesis checkpoint
Sun Aug 01 00:00:00 UTC 2004
Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets.
Experimental cell research
Theis M,Mas C,Döring B,Degen J,Brink C,Caille D,Charollais A,Krüger O,Plum A,Nepote V,Herrera P,Meda P,Willecke K
A-6455 was used in immunohistochemistry - paraffin section to report that native insulin-producing cells express a connexin isoform which differs from those expressed by vascular islet cells
Wed Mar 10 00:00:00 UTC 2004
Fetal cortical allografts project massively through the adult cortex.
Neuroscience
Gaillard F,Domballe L,Gaillard A
A-6455 was used in immunohistochemistry to characterize allogeneic embryonic CNS tissue grafts
Tue Sep 14 00:00:00 UTC 2004
Krüppel-homolog is essential for the coordination of regulatory gene hierarchies in early Drosophila development.
Developmental biology
Beck Y,Pecasse F,Richards G
A-6455 was used in immunohistochemistry to study the role of Kr-h during early Drosophila development
Thu Apr 01 00:00:00 UTC 2004
The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
Developmental biology
Wilm B,James RG,Schultheiss TM,Hogan BL
A-6455 was used in immunohistochemistry to report that Foxc1 and Foxc2 contribute to the specification of mesoderm to paraxial versus intermediate fates
Thu Jul 01 00:00:00 UTC 2004
Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins.
The Journal of biological chemistry
Wang P,Gilmore AP,Streuli CH
A-6455 was used in western blot to elucidate the involvement of Bim in anoikis using mouse mammary epithelial cells
Fri Oct 01 00:00:00 UTC 2004
The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system.
The Journal of biological chemistry
Angers A,Ramjaun AR,McPherson PS
A-6455 was used in immunocytochemistry to assess ubiquitination of endophilin and localization to the trans-Golgi network and endosomal system by the HECT domain ligase itch
Fri Mar 19 00:00:00 UTC 2004
Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana.
Nature
Más P,Kim WY,Somers DE,Kay SA
A-6455 was used in western blot to analyze the modulation of circadian function in Arabidopsis thaliana by targeted degradation of TOC1 by ZTL
Thu Dec 04 00:00:00 UTC 2003
Compartmentalization of integrin alpha6beta4 signaling in lipid rafts.
The Journal of cell biology
Gagnoux-Palacios L,Dans M,van't Hof W,Mariotti A,Pepe A,Meneguzzi G,Resh MD,Giancotti FG
A-6455 was used in immunoprecipitation and western blot to report that alpha6beta4 is incorporated in lipid rafts
Mon Sep 29 00:00:00 UTC 2003
Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3.
Development (Cambridge, England)
Guidato S,Prin F,Guthrie S
A-6455 was used in immunohistochemistry - frozen section to elucidate the mechanisms involved in generating hindbrain motoneurone subtypes.
Tue Jul 01 00:00:00 UTC 2003
Human immunodeficiency virus type 1 protease regulation of tat activity is essential for efficient reverse transcription and replication.
Journal of virology
Apolloni A,Hooker CW,Mak J,Harrich D
A-6455 was used in western blot to investigate how Tat affects the reverse transcription complex.
Mon Sep 01 00:00:00 UTC 2003
Flow cytometry and GFP: a novel assay for measuring the import and turnover of nuclear-encoded mitochondrial proteins in live PC12 cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Sirk DP,Zhu Z,Wadia JS,Mills LR
A-6455 was used in western blot to describe a novel, high-throughput method for measuring protein import in live differentiated PC12 cells.
Sat Nov 01 00:00:00 UTC 2003
DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity.
Genetics
Rogalski TM,Gilbert MM,Devenport D,Norman KR,Moerman DG
A-6455 was used in immunohistochemistry to study the roles of UNC-112 and Dim-1 in muscle development.
Sat Mar 01 00:00:00 UTC 2003
A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei.
Gene
MacLea KS,Krieser RJ,Eastman A
A-6455 was used in western blot to investigate the protein structure of deoxyribonuclease IIalpha.
Thu Feb 13 00:00:00 UTC 2003
Cardiac-type EC-coupling in dysgenic myotubes restored with Ca2+ channel subunit isoforms alpha1C and alpha1D does not correlate with current density.
Biophysical journal
Kasielke N,Obermair GJ,Kugler G,Grabner M,Flucher BE
A-6455 was used in immunocytochemistry to study the restoration with Ca2+ channel subunit isoforms alpha1C and alpha1D that does not correlate with current density by cardiac-type EC-coupling in dysgenic myotubes
Sun Jun 01 00:00:00 UTC 2003
Vacuolar system distribution in Arabidopsis tissues, visualized using GFP fusion proteins.
Journal of experimental botany
Fluckiger R,De Caroli M,Piro G,Dalessandro G,Neuhaus JM,Di Sansebastiano GP
A-6455 was used in Western Blot to show that use of a visible reporter protein (GFP) stably expressed in transgenic plants makes possible the screening for otherwise undetectable mutations.
Sun Jun 01 00:00:00 UTC 2003
The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
The Biochemical journal
Dewaste V,Moreau C,De Smedt F,Bex F,De Smedt H,Wuytack F,Missiaen L,Erneux C
A-6455 was used in Western Blot to highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals.
Fri Aug 15 00:00:00 UTC 2003
GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.
The Journal of biological chemistry
Luke MR,Kjer-Nielsen L,Brown DL,Stow JL,Gleeson PA
A-6455 was used in immunocytochemistry to study two new coiled-coil proteins, GCC88 and GCC185, that perform GRIP domain-mediated targeting to subcompartments of the trans-Golgi network
Fri Feb 07 00:00:00 UTC 2003
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.
Cell
Yang CH,Axelrod JD,Simon MA
A-6455 was used in immunohistochemistry to study planar polarity signaling in the Drosophila compound eye due to regulation of Frizzled by fat-like cadherins
Fri Mar 08 00:00:00 UTC 2002
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Neuron
Bagri A,Marín O,Plump AS,Mak J,Pleasure SJ,Rubenstein JL,Tessier-Lavigne M
A-6455 was used in immunohistochemistry - free floating to analyze prevention of midline crossing and determination of the dorsoventral position of major axonal pathways in the mammalian forebrain by Slit proteins
Thu Jan 17 00:00:00 UTC 2002
The destination for single-pass membrane proteins is influenced markedly by the length of the hydrophobic domain.
The Plant cell
Brandizzi F,Frangne N,Marc-Martin S,Hawes C,Neuhaus JM,Paris N
A-6455 was used in immunocytochemistry to demonstrate that the tonoplast is not a favored default destination for type I membrane proteins in plants.
Wed May 01 00:00:00 UTC 2002
Cytoplasmic linker proteins promote microtubule rescue in vivo.
The Journal of cell biology
Komarova YA,Akhmanova AS,Kojima S,Galjart N,Borisy GG
A-6455 was used in immunocytochemistry to analyze promotion of microtubule rescue in vivo by cytoplasmic linker proteins
Mon Nov 25 00:00:00 UTC 2002
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli.
The Journal of cell biology
Herskovits AA,Shimoni E,Minsky A,Bibi E
A-6455 was used in western blot to study the accumulation of novel membrane-bound ribosome-signal recognition particle receptor complexes and endoplasmic membranes in Escherichia coli
Mon Nov 11 00:00:00 UTC 2002
The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive.
The Journal of cell biology
Calapez A,Pereira HM,Calado A,Braga J,Rino J,Carvalho C,Tavanez JP,Wahle E,Rosa AC,Carmo-Fonseca M
A-6455 was used in immunoprecipitation to analyze intranuclear mobility of messenger RNA binding proteins is temperature sensitive and ATP dependent
Mon Dec 09 00:00:00 UTC 2002
Specificity of glomerular targeting by olfactory sensory axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Treloar HB,Feinstein P,Mombaerts P,Greer CA
A-6455 was used in immunohistochemistry - free floating to assess glomerular targeting specificity by olfactory sensory axons
Mon Apr 01 00:00:00 UTC 2002
The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe.
Molecular and cellular biology
Ozoe F,Kurokawa R,Kobayashi Y,Jeong HT,Tanaka K,Sen K,Nakagawa T,Matsuda H,Kawamukai M
A-6455 was used in immunoprecipitation to show that Rad24 and Rad25 act as negative regulators of Byr2.
Tue Oct 01 00:00:00 UTC 2002
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.
Human gene therapy
Régulier E,Pereira de Almeida L,Sommer B,Aebischer P,Déglon N
A-6455 was used in immunohistochemistry - frozen section to use a tetracycline-regulated lentiviral vectors to investigate the dose-dependent neuroprotective effect of human ciliary neurotrophic factor in the quinolinic acid model of Huntington's disease.
Fri Nov 01 00:00:00 UTC 2002
Meiotic cohesion requires accumulation of ORD on chromosomes before condensation.
Molecular biology of the cell
Balicky EM,Endres MW,Lai C,Bickel SE
A-6455 was used in immunohistochemistry to analyze the requirement of accumulation of ORD on chromosomes before condensation for meiotic cohesion
Fri Nov 01 00:00:00 UTC 2002
Induction of terminal differentiation by the c-Jun dimerization protein JDP2 in C2 myoblasts and rhabdomyosarcoma cells.
The Journal of biological chemistry
Ostrovsky O,Bengal E,Aronheim A
A-6455 was used in immunocytochemistry to assess the role of the c-Jun dimerization protein in muscle cell differentiation.
Fri Oct 18 00:00:00 UTC 2002
Separation and characterization of late endosomal membrane domains.
The Journal of biological chemistry
Kobayashi T,Beuchat MH,Chevallier J,Makino A,Mayran N,Escola JM,Lebrand C,Cosson P,Kobayashi T,Gruenberg J
A-6455 was used in immunocytochemistry to analyze the membrane composition of late endosomes by suborganellar fractionation in the absence of detergent.
Fri Aug 30 00:00:00 UTC 2002
The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal development.
Science's STKE : signal transduction knowledge environment
Polleux F,Ghosh A
A-6455 was used in immunocytochemistry to develop a technique to characterize and identify extracellular signals that regulate neuronal differentiation.
Tue Jun 11 00:00:00 UTC 2002
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila.
Cell
Scott K,Brady R,Cravchik A,Morozov P,Rzhetsky A,Zuker C,Axel R
A-6455 was used in immunohistochemistry to identify and characterize a novel family of gustatory receptors in Drosophila
Fri Mar 09 00:00:00 UTC 2001
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
Cell
Zhou XZ,Lu KP
A-6455 was used in western blot to characterize a potent telomerase inhibitor called PinX1, which is a Pin2/TRF1-interacting protein
Fri Nov 02 00:00:00 UTC 2001
Trophic conversion of an obligate photoautotrophic organism through metabolic engineering.
Science (New York, N.Y.)
Zaslavskaia LA,Lippmeier JC,Shih C,Ehrhardt D,Grossman AR,Apt KE
A-6455 was used in immunocytochemistry and western blot to demonstrate that Phaeodactylum tricornutum can thrive on exogenous glucose in the absence of light when just a glucose transporter is introduced
Fri Jun 15 00:00:00 UTC 2001
senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye.
Neuron
Frankfort BJ,Nolo R,Zhang Z,Bellen H,Mardon G
A-6455 was used in immunohistochemistry to analyze the requirement of R8 photoreceptor differentiation in the developing Drosophila eye by senseless repression of rough
Thu Nov 08 00:00:00 UTC 2001
Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes.
The EMBO journal
Wickham ME,Rug M,Ralph SA,Klonis N,McFadden GI,Tilley L,Cowman AF
A-6455 was used in immunocytochemistry and western blot to characterize Plasmodium falciparum-infected human erythrocytes and assembly and trafficking of the cytoadherence complex
Mon Oct 15 00:00:00 UTC 2001
A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.
The Journal of cell biology
Lechler T,Jonsdottir GA,Klee SK,Pellman D,Li R
A-6455 was used in immunocytochemistry to elucidate the control by Cdc42 for activation and localization of an Arp2/3-activating motor complex in yeast by a two-tiered mechanism
Mon Oct 15 00:00:00 UTC 2001
A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.
The Journal of cell biology
Hoepfner D,van den Berg M,Philippsen P,Tabak HF,Hettema EH
A-6455 was used in immunocytochemistry to study actin, Myo2p, and Vps1p in peroxisome inheritance and abundance in Saccharomyces cerevisiae
Mon Dec 10 00:00:00 UTC 2001
Rapid cycling of lipid raft markers between the cell surface and Golgi complex.
The Journal of cell biology
Nichols BJ,Kenworthy AK,Polishchuk RS,Lodge R,Roberts TH,Hirschberg K,Phair RD,Lippincott-Schwartz J
A-6455 was used in immunocytochemistry to determine the intracellular localization of glycosyl phosphatidylinositol-anchored proteins
Mon Apr 30 00:00:00 UTC 2001
GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration.
Development (Cambridge, England)
Udvadia AJ,Köster RW,Skene JH
A-6455 was used in immunohistochemistry - frozen section to examine gene expression during developmental and regenerative axon growth.
Sun Apr 01 00:00:00 UTC 2001
Requirement for N-ethylmaleimide-sensitive factor activity at different stages of bacterial invasion and phagocytosis.
The Journal of biological chemistry
Coppolino MG,Kong C,Mohtashami M,Schreiber AD,Brumell JH,Finlay BB,Grinstein S,Trimble WS
A-6455 was used in immunocytochemistry to report that membrane protrusions elicited by Salmonella invasion are N-ethylmaleimide-sensitive factor-independent, whereas maturation of Salmonella-containing vacuoles is N-ethylmaleimide-sensitive factor-depend
Fri Feb 16 00:00:00 UTC 2001
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon.
The Journal of biological chemistry
Kishida M,Michiue T,Yamamoto H,Kishida S,Fukui A,Asashima M,Kikuchi A
A-6455 was used in immunoprecipitation to investigate how Dvl and CKIepsilon synergistically activate the Wnt signaling pathway
Fri Aug 31 00:00:00 UTC 2001
G proteins mediate changes in cell shape by stabilizing the axis of polarity.
Molecular cell
Nern A,Arkowitz RA
A-6455 was used in western blot to show that stabilization of the growth axis requires positional signaling from either the pheromone receptor or specific bud site selection proteins
Mon May 01 00:00:00 UTC 2000
Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.
The Journal of cell biology
Toyofuku T,Hong Z,Kuzuya T,Tada M,Hori M
A-6455 was used in immunocytochemistry to study the role of Wnt family proteins in in cardiac myocytes
Mon Jul 10 00:00:00 UTC 2000
E-cadherin-mediated cell-cell attachment activates Cdc42.
The Journal of biological chemistry
Kim SH,Li Z,Sacks DB
A-6455 was used in immunoprecipitation to study the role of Cdc42 in E-cadherin-mediated cell-cell adhesion
Fri Nov 24 00:00:00 UTC 2000
Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.
Genes to cells : devoted to molecular & cellular mechanisms
Sato K,Kimoto M,Kakumoto M,Horiuchi D,Iwasaki T,Tokmakov AA,Fukami Y
A-6455 was used in Immunocytochemistry to demonstrate a dynamic subcellular movement of Shc in response to EGF, and suggested a hitherto unknown scheme whereby Shc can work not only as a substrate of c-Src but also as a mediator of the EGF-induced activation of c-Src in an isoform-specific manner.
Fri Sep 01 00:00:00 UTC 2000
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
The Journal of biological chemistry
Kadoya T,Kishida S,Fukui A,Hinoi T,Michiue T,Asashima M,Kikuchi A
A-6455 was used in immunocytochemistry, immunoprecipitation, and western blot to identify Axam and elucidate how it regulates the Wnt signaling pathway
Fri Nov 24 00:00:00 UTC 2000
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
Proceedings of the National Academy of Sciences of the United States of America
Takaishi H,Konishi H,Matsuzaki H,Ono Y,Shirai Y,Saito N,Kitamura T,Ogawa W,Kasuga M,Kikkawa U,Nishizuka Y
A-6455 was used in immunoprecipitation to study the regulation of intracellular localization of AFX.
Tue Oct 12 00:00:00 UTC 1999
Dual-function reporter protein for analysis of gene expression in living cells.
BioTechniques
Day RN,Kawecki M,Berry D
A-6455 was used in immunoprecipitation and western blot to create and characterize an expression vector encoding a chimeric protein in which green fluorescent protein was tethered to firefly luciferase
Sun Nov 01 00:00:00 UTC 1998
Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis.
The Journal of biological chemistry
Nass R,Rao R
A-6455 was used in western blot to study the role of intracellular Na+/H+ exchangers using yeast
Fri Aug 14 00:00:00 UTC 1998
