Product References
Wolbachia genetically interacts with the bag of marbles germline stem cell gene in male D. melanogaster.
microPublication biology
Wenzel M,Aquadro CF
G10362 was used in Immunohistochemistry-immunofluorescence to shows that the molecular mechanism of Wolbachia 's influence on its hosts' reproduction involves interaction with genes in males as well as females, at least in D. melanogaster.
Sun Sep 22 00:00:00 UTC 2024
The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.
Neuroscience bulletin
Liu J,Liu D,Pu X,Zou K,Xie T,Li Y,Yao H
G10362 was used in Immunohistochemistry to demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior.
Sun Oct 01 00:00:00 UTC 2023
Cell type-specific DNA methylome signatures reveal epigenetic mechanisms for neuronal diversity and neurodevelopmental disorder.
Human molecular genetics
Jin Y,Su K,Kong HE,Ma W,Wang Z,Li Y,Li R,Allen EG,Wu H,Jin P
G10362 was used in Flow Cytometry to suggest that cell type-specific DNA methylation signatures are associated with the functional characteristics of the neuronal subtypes.
Fri Jan 06 00:00:00 UTC 2023
BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging.
Science advances
Blesa J,Pineda-Pardo JA,Inoue KI,Gasca-Salas C,Balzano T,Del Rey NL,Reinares-Sebastián A,Esteban-García N,Rodríguez-Rojas R,Márquez R,Ciorraga M,Del Álamo M,García-Cañamaque L,Ruiz de Aguiar S,Rachmilevitch I,Trigo-Damas I,Takada M,Obeso JA
G10362 was used in Immunohistochemistry to report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson's disease using low-intensity focus ultrasound in adult macaque monkeys.
Fri Apr 21 00:00:00 UTC 2023
Revised iCLIP-seq Protocol for Profiling RNA-protein Interaction Sites at Individual Nucleotide Resolution in Living Cells.
Bio-protocol
Nabeel-Shah S,Greenblatt JF
G10362 was used in Western Blot to describe a step-by-step procedure for our revised iCLIP-seq protocol, that we designate as iCLIP-1.5, and provide alternative approaches for certain difficult-to-CLIP proteins.
Mon Jun 05 00:00:00 UTC 2023
TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
PLoS genetics
Krupp S,Hubbard I,Tam O,Hammell GM,Dubnau J
G10362 was used in Immunohistochemistry to investigate the effects in Drosophila of inducible, glial cell type-specific TAR-DNA binding protein 43 TDP-43 overexpression, a model that causes TDP-43 protein pathology including loss of nuclear TDP-43 and accumulation of cytoplasmic inclusions.
Fri Sep 01 00:00:00 UTC 2023
Postnatal development of hippocampal CA2 structure and function during the emergence of social recognition of peers.
Hippocampus
Diethorn EJ,Gould E
G10362 was used in Immunohistochemistry-immunofluorescence to indicate that the CA2 is partially mature in afferent connectivity by the end of the second postnatal week, connections that likely facilitate the emergence of social recognition memory and preference for novel peers.
Wed Mar 01 00:00:00 UTC 2023
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome.
eLife
Lee D,Chen W,Kaku HN,Zhuo X,Chao ES,Soriano A,Kuncheria A,Flores S,Kim JH,Rivera A,Rigo F,Jafar-Nejad P,Beaudet AL,Caudill MS,Xue M
G10362 was used in Immunohistochemistry-immunofluorescence to indicate that the therapeutic window of genetic therapies for Angelman syndrome is broader than previously thought, and EEG power spectrum and sleep architecture should be used to evaluate the clinical efficacy of therapies.
Tue Jan 03 00:00:00 UTC 2023
A NPAS4-NuA4 complex couples synaptic activity to DNA repair.
Nature
Pollina EA,Gilliam DT,Landau AT,Lin C,Pajarillo N,Davis CP,Harmin DA,Yap EL,Vogel IR,Griffith EC,Nagy MA,Ling E,Duffy EE,Sabatini BL,Weitz CJ,Greenberg ME
G10362 was used in Magnetic cell separation to developmental disorders, neurodegeneration and ageing.
Wed Feb 01 00:00:00 UTC 2023
The mitochondrial ribosomal protein mRpL4 regulates Notch signaling.
EMBO reports
Mo D,Liu C,Chen Y,Cheng X,Shen J,Zhao L,Zhang J
G10362 was used in Western Blot to show that human mRpL4 is capable of replacing fly mRpL4 during wing development.
Mon Jun 05 00:00:00 UTC 2023
Fast and sensitive GCaMP calcium indicators for imaging neural populations.
Nature
Zhang Y,Rózsa M,Liang Y,Bushey D,Wei Z,Zheng J,Reep D,Broussard GJ,Tsang A,Tsegaye G,Narayan S,Obara CJ,Lim JX,Patel R,Zhang R,Ahrens MB,Turner GC,Wang SS,Korff WL,Schreiter ER,Svoboda K,Hasseman JP,Kolb I,Looger LL
G10362 was used in Immunohistochemistry-immunofluorescence to show that jGCaMP8 sensors will allow tracking of large populations of neurons on timescales relevant to neural computation.
Wed Mar 01 00:00:00 UTC 2023
Wolbachia infection at least partially rescues the fertility and ovary defects of several new Drosophila melanogaster bag of marbles protein-coding mutants.
PLoS genetics
Wenzel M,Aquadro CF
G10362 was used in Immunocytochemistry to test if wMel interacts with bam in a non-specific way, by increasing bam transcript levels or acting upstream in germline stem cells.
Sun Oct 01 00:00:00 UTC 2023
Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Oyama K,Hori Y,Nagai Y,Miyakawa N,Mimura K,Hirabayashi T,Inoue KI,Takada M,Higuchi M,Minamimoto T
G10362 was used in Immunohistochemistry to indicate that orally delivered deschloroclozapine produces long-term stable chemogenetic effects, and holds great promise for the translational use of DREADDs technology.
Wed Mar 23 00:00:00 UTC 2022
Cerebral endothelial cell derived small extracellular vesicles improve cognitive function in aged diabetic rats.
Frontiers in aging neuroscience
Zhang L,Li C,Huang R,Teng H,Zhang Y,Zhou M,Liu X,Fan B,Luo H,He A,Zhao A,Lu M,Chopp M,Zhang ZG
G10362 was used in Immunohistochemistry to provide ex vivo and in vivo evidence that DM-CEC-sEVs induce cerebral vascular dysfunction and neurogenesis impairment.
Tue Aug 08 00:00:00 UTC 2023
Distinct signaling signatures drive compensatory proliferation via S-phase acceleration.
PLoS genetics
Crucianelli C,Jaiswal J,Vijayakumar Maya A,Nogay L,Cosolo A,Grass I,Classen AK
G10362 was used in Immunohistochemistry to find that compensatory proliferation is associated with a unique cell cycle profile, which is characterized by short G1 and G2 phases and, surprisingly, by acceleration of the S-phase.
Thu Dec 01 00:00:00 UTC 2022
Behavioural and dopaminergic signatures of resilience.
Nature
Willmore L,Cameron C,Yang J,Witten IB,Falkner AL
G10362 was used in Immunohistochemistry to record behaviour in mice simultaneously with DA neuron activity in projections to the nucleus accumbens (NAc) (which signals reward9-12) and the tail striatum (TS) (which signals threat13-16) during social defeat.
Tue Nov 01 00:00:00 UTC 2022
Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.
Nature communications
Patel T,Hammelman J,Aziz S,Jang S,Closser M,Michaels TL,Blum JA,Gifford DK,Wichterle H
G10362 was used in Immunoprecipitation to conclude that the genetic maturation program consists of a core hardwired subprogram that is correctly executed in vitro and an extrinsically-controlled subprogram that is dependent on the in vivo context of the maturing organism.
Thu Sep 15 00:00:00 UTC 2022
SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.
iScience
Nabeel-Shah S,Lee H,Ahmed N,Burke GL,Farhangmehr S,Ashraf K,Pu S,Braunschweig U,Zhong G,Wei H,Tang H,Yang J,Marcon E,Blencowe BJ,Zhang Z,Greenblatt JF
G10362 was used in Immunoprecipitation to show that the N protein rewires the G3BP1 mRNA-binding profile and suppresses the physiological stress response of host cells, which may explain the imbalanced immune response observed in SARS-CoV-2 infected patients.
Fri Jan 21 00:00:00 UTC 2022
Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology.
Cellular and molecular life sciences : CMLS
Heinze A,Schuldt C,Khudayberdiev S,van Bommel B,Hacker D,Schulz TG,Stringhi R,Marcello E,Mikhaylova M,Rust MB
G10362 was used in Western Blot to identify CAP1 as a novel regulator of the postsynaptic actin cytoskeleton that is essential for synaptic cofilin1 activity.
Thu Oct 20 00:00:00 UTC 2022
Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning.
Cell reports
Parker NF,Baidya A,Cox J,Haetzel LM,Zhukovskaya A,Murugan M,Engelhard B,Goldman MS,Witten IB
G10362 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to suggest two alternative models for the circuitry and mechanisms underlying reinforcement learning.
Tue May 17 00:00:00 UTC 2022
Prss29 Cre recombinase mice are useful to study adult uterine gland function.
Genesis (New York, N.Y. : 2000)
Kelleher AM,Allen CC,Davis DJ,Spencer TE
G10362 was used in Immunohistochemistry (Frozen) to describe a new uterine glandular epithelium specific Cre recombinase mouse line that is useful for the study of uterine gland function during pregnancy.
Thu Dec 01 00:00:00 UTC 2022
Membrane composition and organization of Bacillus subtilis 168 and its genome-reduced derivative miniBacillus PG10.
Microbial biotechnology
van Tilburg AY,Warmer P,van Heel AJ,Sauer U,Kuipers OP
G10362 was used in Western Blotting to measure relative abundances of lipids in detergent-resistant and detergent-sensitive membrane fractions of the model bacterium Bacillus subtilis 168 and miniBacillus PG10 strain.
Sun May 01 00:00:00 UTC 2022
Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum.
Nature communications
Carpenter MD,Fischer DK,Zhang S,Bond AM,Czarnecki KS,Woolf MT,Song H,Heller EA
G10362 was used in Immunohistochemistry-immunofluorescence to understand combinatorial relationships between neuronal-subtype-specific epigenetic modifications and gene expression.
Tue Dec 13 00:00:00 UTC 2022
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression.
eLife
Baccino-Calace M,Schmidt K,Müller M
G10362 was used in Western Blotting and Immunohistochemistry to show that the E3 ligase Thin links protein degradation-dependent proteostasis of Dysbindin to homeostatic regulation of neurotransmitter release.
Thu Jul 07 00:00:00 UTC 2022
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression.
eLife
Baccino-Calace M,Schmidt K,Müller M
G10362 was used in Western Blotting and Immunohistochemistry to show that the E3 ligase Thin links protein degradation-dependent proteostasis of Dysbindin to homeostatic regulation of neurotransmitter release.
Thu Jul 07 00:00:00 UTC 2022
Interneurons of fan-shaped body promote arousal in Drosophila.
PloS one
Kato YS,Tomita J,Kume K
G10362 was used in Immunohistochemistry-immunofluorescence to suggest the role of FB interneurons in sleep regulation.
Wed Nov 23 00:00:00 UTC 2022
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nature communications
Liu Y,Iqbal A,Li W,Ni Z,Wang Y,Ramprasad J,Abraham KJ,Zhang M,Zhao DY,Qin S,Loppnau P,Jiang H,Guo X,Brown PJ,Zhen X,Xu G,Mekhail K,Ji X,Bedford MT,Greenblatt JF,Min J
G10362 was used in Western Blotting to show that RNAi and CRISPR/Cas9 techniques, potent SMN antagonists could be used as an efficient tool to understand the biological functions of SMN.
Fri Sep 16 00:00:00 UTC 2022
Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.
Nature communications
Weichselberger V,Dondl P,Classen AK
G10362 was used in Immunohistochemistry-immunofluorescence to demonstrate that differential affinity between cell lineages is sufficient to drive the complex assembly of inter-lineage functional units and underlies tissue self-organization during Drosophila oogenesis.
Wed Oct 26 00:00:00 UTC 2022
In Situ Quantification and Isolation of Müller Glial Cells by Fluorescence-Activated Cell Sorting from the Regenerating Larval Zebrafish Retina.
Methods in molecular biology (Clifton, N.J.)
Stulberg J,Tropepe V
G10362 was used in Immunohistochemistry-immunofluorescence to provide a protocol to both quantify MG cell dedifferentiation behavior during a regenerative response and isolate MG cells by fluorescence activated cell sorting (FACS).
Fri May 06 00:00:00 UTC 2022
Molecular and functional architecture of striatal dopamine release sites.
Neuron
Banerjee A,Imig C,Balakrishnan K,Kershberg L,Lipstein N,Uronen RL,Wang J,Cai X,Benseler F,Rhee JS,Cooper BH,Liu C,Wojcik SM,Brose N,Kaeser PS
G10362 was used in Immunohistochemistry to establish that efficient release site architecture mediates fast dopamine exocytosis.
Wed Jan 19 00:00:00 UTC 2022
Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome.
Communications biology
Estève PO,Sen S,Vishnu US,Ruse C,Chin HG,Pradhan S
G10362 was used in Immunoprecipitation to conclude that SET8 mediated chromatin remodeling in mammalian cells are modulated by poly ADP-ribosylation by PARP1.
Fri Nov 25 00:00:00 UTC 2022
Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes.
Cell reports
Fleming W,Lee J,Briones BA,Bolkan SS,Witten IB
G10362 was used in Immunohistochemistry-immunofluorescence to find that high endogenous acetylcholine event frequency correlates with greater extinction of cocaine-context associations across male mice.
Tue May 31 00:00:00 UTC 2022
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.
Nucleic acids research
Nabeel-Shah S,Garg J,Saettone A,Ashraf K,Lee H,Wahab S,Ahmed N,Fine J,Derynck J,Pu S,Ponce M,Marcon E,Zhang Z,Greenblatt JF,Pearlman RE,Lambert JP,Fillingham J
G10362 was used in Immunoprecipitation to suggest the essentiality of RebL1 functions in multiple epigenetic regulatory complexes in which it impacts transcription regulation and cellular viability.
Mon Jun 21 00:00:00 UTC 2021
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation.
Developmental cell
Zarkada G,Howard JP,Xiao X,Park H,Bizou M,Leclerc S,Künzel SE,Boisseau B,Li J,Cagnone G,Joyal JS,Andelfinger G,Eichmann A,Dubrac A
G10362 was used in Immunohistochemistry to show that diving tip cells invading the mouse neuroretina (D-tip cells) are distinct from tip cells guiding the superficial retinal vascular plexus (S-tip cells).
Mon Aug 09 00:00:00 UTC 2021
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling.
Cardiovascular research
Ebeid DE,Khalafalla FG,Broughton KM,Monsanto MM,Esquer CY,Sacchi V,Hariharan N,Korski KI,Moshref M,Emathinger J,Cottage CT,Quijada PJ,Nguyen JH,Alvarez R,Völkers M,Konstandin MH,Wang BJ,Firouzi F,Navarrete JM,Gude NA,Goumans MJ,Sussman MA
G10362 was used in Western Blotting to delineate the mechanism of telomere length regulation by the interplay between Pim1 and components of TGFβ signaling pathways.
Fri Jan 01 00:00:00 UTC 2021
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
PLoS pathogens
Cerny O,Godlee C,Tocci R,Cross NE,Shi H,Williamson JC,Alix E,Lehner PJ,Holden DW
G10362 was used in Immunoprecipitation to find that SteD targets the plasma membrane protein CD97 for degradation by a similar mechanism.
Thu Jul 01 00:00:00 UTC 2021
Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Li C,Wang C,Zhang Y,Alsrouji OK,Chebl AB,Ding G,Jiang Q,Mayer SA,Lu M,Kole MK,Marin HL,Zhang L,Chopp M,Zhang ZG
G10362 was used in Sample Preparation to conclude that CEC-sEVs have a therapeutic effect on acute ischemic stroke by reducing neurovascular damage.
Sun Aug 01 00:00:00 UTC 2021
UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II.
Journal of cell science
Habicht J,Mooneyham A,Hoshino A,Shetty M,Zhang X,Emmings E,Yang Q,Coombes C,Gardner MK,Bazzaro M
G10362 was used in Western Blot to investigate that if in vitro and in cells, UNC-45A binds to the microtubule lattice leading to microtubule bending, breakage and depolymerization.
Fri Jan 08 00:00:00 UTC 2021
Imaging of In Vitro and In Vivo Neurons in Drosophila Using Stochastic Optical Reconstruction Microscopy.
Current protocols
Inal MA,Bui KC,Marar A,Li S,Kner P,Kamiyama D
G10362 was used in Immunohistochemistry to open up the potential to investigate cell-cell interactions using STORM in the Drosophila nervous system.
Thu Jul 01 00:00:00 UTC 2021
Adult-born granule cell mossy fibers preferentially target parvalbumin-positive interneurons surrounded by perineuronal nets.
Hippocampus
Briones BA,Pisano TJ,Pitcher MN,Haye AE,Diethorn EJ,Engel EA,Cameron HA,Gould E
G10362 was used in Immunohistochemistry-immunofluorescence to identify adult-born granule cells (abGCs) projections to parvalbumin-positive (PV+) interneurons with perineuronal nets (PNNs), with more presumed abGC mossy fiber boutons found near the cell body of PV+ interneurons with strong PNNs.
Thu Apr 01 00:00:00 UTC 2021
INTACT vs. FANS for Cell-Type-Specific Nuclei Sorting: A Comprehensive Qualitative and Quantitative Comparison.
International journal of molecular sciences
Chongtham MC,Butto T,Mungikar K,Gerber S,Winter J
G10362 was used in Flow Cytometry to compare the physical and molecular attributes of sfGFP+ nuclei isolated by the two methods-INTACT and FANS-from the neocortices of Arc-CreERT2 × CAG-Sun1/sfGFP animals.
Wed May 19 00:00:00 UTC 2021
Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets.
iScience
Mimura K,Nagai Y,Inoue KI,Matsumoto J,Hori Y,Sato C,Kimura K,Okauchi T,Hirabayashi T,Nishijo H,Yahata N,Takada M,Suhara T,Higuchi M,Minamimoto T
G10362 was used in Immunohistochemistry to interrogate particular neuronal pathways in nonhuman primates under natural and stress-free conditions.
Fri Sep 24 00:00:00 UTC 2021
Autophagy Receptor Protein Tax1-Binding Protein 1/TRAF6-Binding Protein Is a Cellular Substrate of Enteroviral Proteinase.
Frontiers in microbiology
Mohamud Y,Xue YC,Liu H,Ng CS,Bahreyni A,Luo H
G10362 was used in Immunoprecipitation to explore the effects enterovirus-induced diversion of autophagy on organelle quality control.
Tue Jun 22 00:00:00 UTC 2021
Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing.
STAR protocols
Loft A,Herzig S,Schmidt SF
G10362 was used in Immunoprecipitation to present an improved protocol for isolation of pure and high-quality GFP-labeled nuclei from frozen livers of INTACT mice, as well as protocols for downstream sequencing analyses.
Fri Sep 17 00:00:00 UTC 2021
Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making.
Science advances
Oyama K,Hori Y,Nagai Y,Miyakawa N,Mimura K,Hirabayashi T,Inoue KI,Suhara T,Takada M,Higuchi M,Minamimoto T
G10362 was used in Immunohistochemistry to investigate the dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates.
Tue Jun 01 00:00:00 UTC 2021
Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity.
Science advances
Wahane S,Zhou X,Zhou X,Guo L,Friedl MS,Kluge M,Ramakrishnan A,Shen L,Friedel CC,Zhang B,Friedel RH,Zou H
G10362 was used in Flow Cytometry to unveil diversification of myeloid and glial subtypes in SCI and an extensive influence of HDAC3, which may be exploited to enhance functional recovery.
Mon Feb 01 00:00:00 UTC 2021
A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila.
eLife
Lee K,Doe CQ
G10362 was used in Immunocytochemistry to utilize a well-characterized neural circuit in the Drosophila larva: the moonwalker descending neuron (MDN) circuit.
Wed Jul 14 00:00:00 UTC 2021
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.
Cell reports
Wei H,Wu X,You Y,Duran RC,Zheng Y,Narayanan KL,Hai B,Li X,Tallapragada N,Prajapati TJ,Kim DH,Deneen B,Cao QL,Wu JQ
G10362 was used in Immunocytochemistry to study the molecular changes in the injury environment and the astrocyte-specific responses by astrocyte purification from injured spinal cords from acute to chronic stages.
Tue Feb 02 00:00:00 UTC 2021
Electrical synaptic transmission requires a postsynaptic scaffolding protein.
eLife
Lasseigne AM,Echeverry FA,Ijaz S,Michel JC,Martin EA,Marsh AJ,Trujillo E,Marsden KC,Pereda AE,Miller AC
G10362 was used in Immunohistochemistry to investigate the functional role of Zonula Occludens 1 in zebrafish by examining identifiable synaptic contacts of the Mauthner cell which forms stereotyped electrical synapses accessible to genetic, biochemical, cell biological, electrophysiological, and behavioral analyses.
Wed Apr 28 00:00:00 UTC 2021
Direct and indirect pathway neurons in ventrolateral striatum differentially regulate licking movement and nigral responses.
Cell reports
Chen Z,Zhang ZY,Zhang W,Xie T,Li Y,Xu XH,Yao H
G10362 was used in Immunohistochemistry to understand how direct and indirect pathways control the lick bout and individual spout contact in rodents.
Tue Oct 19 00:00:00 UTC 2021
Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer.
Journal of extracellular vesicles
Zhang Y,Li C,Qin Y,Cepparulo P,Millman M,Chopp M,Kemper A,Szalad A,Lu X,Wang L,Zhang ZG
G10362 was used in Immunohistochemistry to demonstrate that CEC-sEVs suppressed CIPN and enhanced chemotherapy of oxaliplatin in the mouse bearing ovarian tumour.
Mon Mar 01 00:00:00 UTC 2021
Addiction-Associated Genetic Variants Implicate Brain Cell Type- and Region-Specific Cis-Regulatory Elements in Addiction Neurobiology.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Srinivasan C,Phan BN,Lawler AJ,Ramamurthy E,Kleyman M,Brown AR,Kaplow IM,Wirthlin ME,Pfenning AR
G10362 was used in Immunocytochemistry-immunofluorescence to suggest that different neuronal subtypes within the reward system play distinct roles in the variety of traits that contribute to addiction.
Wed Oct 27 00:00:00 UTC 2021
Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice.
Neuroscience insights
Coles C,Lasek AW
G10362 was used in Immunohistochemistry to test a hypothesis that levels of OTX2 would be altered by binge-like ethanol consumption in adult animals.
Sun May 09 00:00:00 UTC 2021
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
PloS one
Datta P,Cribbs JT,Seo S
G10362 was used in Western Blot to show that Nphp1 genetically interacts with Cep290, another NPHP gene, and that a reduction of Cep290 gene dose results in retinal degeneration that continues until adulthood in Nphp1 mutant mice.
Wed Jul 24 00:00:00 UTC 2024
Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin.
Neuron
Osso LA,Rankin KA,Chan JR
G10362 was used in Immunohistochemistry-immunofluorescence to propose a new model where myelination is mediated by neuropeptide-expressing neurons that promote OPC differentiation.
Wed Nov 17 00:00:00 UTC 2021
FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model.
NPJ aging and mechanisms of disease
Criado-Marrero M,Gebru NT,Gould LA,Blazier DM,Vidal-Aguiar Y,Smith TM,Abdelmaboud SS,Shelton LB,Wang X,Dahrendorff J,Beaulieu-Abdelahad D,Dickey CA,Blair LJ
G10362 was used in Western Blot to suggest that FKBP52 may sensitize neurons to tau-mediated dysfunction via activation of a caspase-dependent pathway, contributing to memory and learning impairments.
Mon May 03 00:00:00 UTC 2021
Amygdala inhibitory neurons as loci for translation in emotional memories.
Nature
Shrestha P,Shan Z,Mamcarz M,Ruiz KSA,Zerihoun AT,Juan CY,Herrero-Vidal PM,Pelletier J,Heintz N,Klann E
G10362 was used in Immunohistochemistry-immunofluorescence to investigate the role of de novo protein synthesis in amygdala inhibitory neurones during the consolidation of long-term emotional memories using mice models.
Thu Oct 01 00:00:00 UTC 2020
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Cell host & microbe
Alix E,Godlee C,Cerny O,Blundell S,Tocci R,Matthews S,Liu M,Pruneda JN,Swatek KN,Komander D,Sleap T,Holden DW
G10362 was used in Western Blotting to show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembrane protein of unknown biochemical function, TMEM127, are required for SteD-dependent ubiquitination of mMHCII.
Wed Jul 08 00:00:00 UTC 2020
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Nature neuroscience
Shrestha P,Ayata P,Herrero-Vidal P,Longo F,Gastone A,LeDoux JE,Heintz N,Klann E
G10362 was used in Immunohistochemistry to provide evidence for a cell-specific translation program during consolidation of threat memories.
Sat Feb 01 00:00:00 UTC 2020
Preservation of a remote fear memory requires new myelin formation.
Nature neuroscience
Pan S,Mayoral SR,Choi HS,Chan JR,Kheirbek MA
G10362 was used in Immunohistochemistry to conclude that bidirectional manipulation of myelin plasticity functionally affects behavior and neurophysiology, which suggests that neural activity during fear learning instructs the formation of new myelin, which in turn supports the consolidation and/or retrieval of remote fear memories.
Wed Apr 01 00:00:00 UTC 2020
Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2.
Nature neuroscience
Zhou X,Wahane S,Friedl MS,Kluge M,Friedel CC,Avrampou K,Zachariou V,Guo L,Zhang B,He X,Friedel RH,Zou H
G10362 was used in Immunopurification to elucidate a temporally distinct gene signature in injury-activated microglia and macrophages (IAMs) that engages axon guidance pathways.
Sun Mar 01 00:00:00 UTC 2020
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Nature cell biology
Zhang R,Lee DM,Jimah JR,Gerassimov N,Yang C,Kim S,Luvsanjav D,Winkelman J,Mettlen M,Abrams ME,Kalia R,Keene P,Pandey P,Ravaux B,Kim JH,Ditlev JA,Zhang G,Rosen MK,Frost A,Alto NM,Gardel M,Schmid SL,Svitkina TM,Hinshaw JE,Chen EH
G10362 was used in Immunocytochemistry to reveal a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo.
Mon Jun 01 00:00:00 UTC 2020
An Activity-Mediated Transition in Transcription in Early Postnatal Neurons.
Neuron
Stroud H,Yang MG,Tsitohay YN,Davis CP,Sherman MA,Hrvatin S,Ling E,Greenberg ME
G10362 was used in Immunoprecipitation to show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity.
Wed Sep 09 00:00:00 UTC 2020
LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
Neuron
Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ
G10362 was used in Immunocytochemistry-immunoflourescence to show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modification to induce presynaptic differentiation.
Wed Apr 08 00:00:00 UTC 2020
Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice.
Diabetes
Wang L,Chopp M,Szalad A,Lu X,Zhang Y,Wang X,Cepparulo P,Lu M,Li C,Zhang ZG
G10362 was used in Immunomicroscopy to propose that exosomes derived from healthy Schwann cells have a therapeutic effect on diabetic peripheral neuropathy in mice, potentially through the modulation of miRs.
Wed Apr 01 00:00:00 UTC 2020
Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.
Development (Cambridge, England)
Brandt ZJ,Echert AE,Bostrom JR,North PN,Link BA
G10362 was used in Immunocytochemistry to define a role for Hippo-Yap signaling in the maintenance of both intra- and extrahepatic biliary ducts.
Mon Jun 22 00:00:00 UTC 2020
Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aponte-Santiago NA,Ormerod KG,Akbergenova Y,Littleton JT
G10362 was used in Immunocytochemistry to characterize how changes in the presence or activity of tonic Ib versus phasic Is motoneurons alter neuromuscular junction development and function in Drosophila.
Wed Aug 12 00:00:00 UTC 2020
Cell Type-Specific Oxidative Stress Genomic Signatures in the Globus Pallidus of Dopamine-Depleted Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lawler AJ,Brown AR,Bouchard RS,Toong N,Kim Y,Velraj N,Fox G,Kleyman M,Kang B,Gittis AH,Pfenning AR
G10362 was used in Affinity Purification to assess the cell type-specific transcriptomic and epigenetic effects of decreased dopamine on PV+ and PV- cells in mice.
Wed Dec 09 00:00:00 UTC 2020
The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization.
Journal of cell science
Sen A,Hsieh WC,Hanna CB,Hsu CC,Pearson M,Tao WA,Aguilar RC
G10362 was used in Immunoprecipitation to indicate that the yeast Na+ pump Ena1 is an epsin (Ent1 and Ent2 in yeast)-specific cargo and that its internalization requires K1090, which likely undergoes Art3-dependent ubiquitylation.
Fri Aug 21 00:00:00 UTC 2020
Towards mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells.
Methods (San Diego, Calif.)
Wollman AJM,Hedlund EG,Shashkova S,Leake MC
G10362 was used in In vitro Assay to describe a single-molecule bioimaging method utilizing super-localization precision coupled to fully quantitative image analysis tools, towards determining snapshots of parts of the 3D genome architecture of model eukaryote budding yeast Saccharomyces cerevisiae with exceptional millisecond time resolution.
Wed Jan 01 00:00:00 UTC 2020
Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons.
Genetics
Petruccelli E,Brown T,Waterman A,Ledru N,Kaun KR
G10362 was used in RNA Immunoprecipitation to investigate the lasting consequences of ethanol on transcription in memory-encoding neurons.
Fri May 01 00:00:00 UTC 2020
Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells.
Veterinary research
Han C,Du Q,Zhu L,Chen N,Luo L,Chen Q,Yin J,Wu X,Tong D,Huang Y
G10362 was used in Immunoprecipitation to show a novel function of pDNAJB6 in regulation of porcine circovirus replication that pDNAJB6 enhances the formation of autophagy to promote viral replication through interacting with viral capsid protein during PCV2 infection.
Thu May 07 00:00:00 UTC 2020
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.
Channels (Austin, Tex.)
Wang Z,Vermij SH,Sottas V,Shestak A,Ross-Kaschitza D,Zaklyazminskaya EV,Hudmon A,Pitt GS,Rougier JS,Abriel H
G10362 was used in Immunocytochemistry to understand of BrS pathophysiology.
Tue Dec 01 00:00:00 UTC 2020
Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors.
The Journal of biological chemistry
Cochrane VA,Wu Y,Yang Z,ElSheikh A,Dunford J,Kievit P,Fortin DA,Shyng SL
G10362 was used in Immunoprecipitation, Immunocytochemistry to reveal a signaling pathway wherein leptin modulates NMDARs via Src to regulate β-cell excitability and suggests NMDARs as a potential target to overcome leptin resistance.
Fri Dec 11 00:00:00 UTC 2020
Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors.
The Journal of biological chemistry
Cochrane VA,Wu Y,Yang Z,ElSheikh A,Dunford J,Kievit P,Fortin DA,Shyng SL
G10362 was used in Immunoprecipitation, Immunocytochemistry to reveal a signaling pathway wherein leptin modulates NMDARs via Src to regulate β-cell excitability and suggests NMDARs as a potential target to overcome leptin resistance.
Fri Dec 11 00:00:00 UTC 2020
A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory.
Cell reports
Choi JY,Jang HJ,Ornelas S,Fleming WT,Fürth D,Au J,Bandi A,Engel EA,Witten IB
G10362 was used in Immunohistochemistry to reveal a surprising dissociation between when VTA-DA neurons are most active and when they have the biggest causal contribution to short-term memory.
Tue Dec 15 00:00:00 UTC 2020
Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.
bioRxiv : the preprint server for biology
Prasanth KR,Hirano M,Fagg WS,McAnarney ET,Shan C,Xie X,Hage A,Pietzsch CA,Bukreyev A,Rajsbaum R,Shi PY,Bedford MT,Bradrick SS,Menachery V,Garcia-Blanco MA
G10362 was used in Western Blot to demonstrate the role of Topoisomerase III-ß in yellow fever virus and dengue virus-2 replication.
Fri Mar 27 00:00:00 UTC 2020
Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury.
Cell death & disease
Sada N,Fujita Y,Mizuta N,Ueno M,Furukawa T,Yamashita T
G10362 was used in Immunoprecipitation to investigate the effects of the HDAC inhibition on the expression of brain-derived neurotrophic factor and functional recovery after traumatic brain injury in mice.
Tue Aug 18 00:00:00 UTC 2020
Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2.
eLife
Wang X,Ellenbecker M,Hickey B,Day NJ,Osterli E,Terzo M,Voronina E
G10362 was used in Proximity Ligation Assay (PLA), Immunohistochemistry to propose that the opposing FBF-1 and FBF-2 activities in Caenorhabditis elegans serve to modulate stem cell division rate simultaneously with the rate of meiotic entry.
Mon Aug 17 00:00:00 UTC 2020
Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2.
eLife
Wang X,Ellenbecker M,Hickey B,Day NJ,Osterli E,Terzo M,Voronina E
G10362 was used in Proximity Ligation Assay (PLA), Immunohistochemistry to propose that the opposing FBF-1 and FBF-2 activities in Caenorhabditis elegans serve to modulate stem cell division rate simultaneously with the rate of meiotic entry.
Mon Aug 17 00:00:00 UTC 2020
In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay.
Journal of visualized experiments : JoVE
Day NJ,Wang X,Voronina E
G10362 was used in Immunocytochemistry to probe PPIs in the C. elegans germline.
Tue May 05 00:00:00 UTC 2020
Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization.
Cell host & microbe
Panagi I,Jennings E,Zeng J,Günster RA,Stones CD,Mak H,Jin E,Stapels DAC,Subari NZ,Pham THM,Brewer SM,Ong SYQ,Monack DM,Helaine S,Thurston TLM
G10362 was used in Western Blot to demonstrate that SteE converts both the amino acid and substrate specificity of the host pleiotropic serine/threonine kinase GSK3.
Wed Jan 08 00:00:00 UTC 2020
Vibrio cholerae-Symbiont Interactions Inhibit Intestinal Repair in Drosophila.
Cell reports
Fast D,Petkau K,Ferguson M,Shin M,Galenza A,Kostiuk B,Pukatzki S,Foley E
G10362 was used in Immunocytochemistry to highlight the importance of pathogen-symbiont interactions for intestinal immune responses and outline the impact of the type six secretion system on pathogenesis.
Tue Jan 28 00:00:00 UTC 2020
MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.
Cell reports
Wolf EJ,Miles A,Lee ES,Nabeel-Shah S,Greenblatt JF,Palazzo AF,Tropepe V,Emili A
G10362 was used in Immunopurification to suggest that MKRN2 interacts with GLE1 to selectively regulate mRNA nuclear export and retinal development.
Tue May 26 00:00:00 UTC 2020
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Nature communications
Szewczyk MM,Ishikawa Y,Organ S,Sakai N,Li F,Halabelian L,Ackloo S,Couzens AL,Eram M,Dilworth D,Fukushi H,Harding R,Dela Seña CC,Sugo T,Hayashi K,McLeod D,Zepeda C,Aman A,Sánchez-Osuna M,Bonneil E,Takagi S,Al-Awar R,Tyers M,Richard S,Takizawa M,Gingras AC,Arrowsmith CH,Vedadi M,Brown PJ,Nara H,Barsyte-Lovejoy D
G10362 was used in Immunoprecipitation to demonstrate a role for PRMT7 and arginine methylation in stress response.
Thu May 14 00:00:00 UTC 2020
Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner.
eLife
Guan Z,Quiñones-Frías MC,Akbergenova Y,Littleton JT
G10362 was used in Immunocytochemistry-immunoflourescence to determine if Drosophila Syt7 plays a conserved role as the Ca2+ sensor for asynchronous fusion and short-term facilitation.
Tue Apr 28 00:00:00 UTC 2020
Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons.
Nature
Engelhard B,Finkelstein J,Cox J,Fleming W,Jang HJ,Ornelas S,Koay SA,Thiberge SY,Daw ND,Tank DW,Witten IB
G10362 was used in Immunohistochemistry-immunofluorescence to aid downstream circuits in correctly interpreting the wide range of signals transmitted by dopamine neurons.
Sat Jun 01 00:00:00 UTC 2019
EPIC: software toolkit for elution profile-based inference of protein complexes.
Nature methods
Hu LZ,Goebels F,Tan JH,Wolf E,Kuzmanov U,Wan C,Phanse S,Xu C,Schertzberg M,Fraser AG,Bader GD,Emili A
G10362 was used in Mass Spectrometry to describe EPIC (elution profile-based inference of complexes), a software toolkit for automated scoring of large-scale CF-MS data to define high-confidence multi-component macromolecules from diverse biological specimens.
Thu Aug 01 00:00:00 UTC 2019
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Nature genetics
Sdelci S,Rendeiro AF,Rathert P,You W,Lin JG,Ringler A,Hofstätter G,Moll HP,Gürtl B,Farlik M,Schick S,Klepsch F,Oldach M,Buphamalai P,Schischlik F,Májek P,Parapatics K,Schmidl C,Schuster M,Penz T,Buckley DL,Hudecz O,Imre R,Wang SY,Maric HM,Kralovics R,Bennett KL,Müller AC,Mechtler K,Menche J,Bradner JE,Winter GE,Klavins K,Casanova E,Bock C,Zuber J,Kubicek S
G10362 was used in Western Blotting to describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).
Sat Jun 01 00:00:00 UTC 2019
MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
Nature genetics
Sdelci S,Rendeiro AF,Rathert P,You W,Lin JG,Ringler A,Hofstätter G,Moll HP,Gürtl B,Farlik M,Schick S,Klepsch F,Oldach M,Buphamalai P,Schischlik F,Májek P,Parapatics K,Schmidl C,Schuster M,Penz T,Buckley DL,Hudecz O,Imre R,Wang SY,Maric HM,Kralovics R,Bennett KL,Müller AC,Mechtler K,Menche J,Bradner JE,Winter GE,Klavins K,Casanova E,Bock C,Zuber J,Kubicek S
G10362 was used in Western Blotting to describe two complementary screens for genetic and physical interactors of BRD4, which converge on the folate pathway enzyme MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).
Sat Jun 01 00:00:00 UTC 2019
Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons.
Neuron
Cameron CM,Murugan M,Choi JY,Engel EA,Witten IB
G10362 was used in Immunohistochemistry (Frozen) to show that altered IL-NAc activity after a drug-free period may enhance cocaine motivation without fundamentally altering the projection's ability to inhibit drug seeking.
Wed Jul 03 00:00:00 UTC 2019
ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation.
Neuron
Sharma N,Pollina EA,Nagy MA,Yap EL,DiBiase FA,Hrvatin S,Hu L,Lin C,Greenberg ME
G10362 was used in ATAC-seq experiments to conclude that the interplay of bHLH-PAS complexes at activity-dependent regulatory elements maintains temporal control of activity-dependent gene expression and scales somatic inhibition with circuit activity.
Wed Apr 17 00:00:00 UTC 2019
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC
G10362 was used in Immunocytochemistry to validate the potential pathogenicity of RPGR missense variants.
Tue Jan 22 00:00:00 UTC 2019
A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies.
American journal of human genetics
Nixon KCJ,Rousseau J,Stone MH,Sarikahya M,Ehresmann S,Mizuno S,Matsumoto N,Miyake N,Baralle D,McKee S,Izumi K,Ritter AL,Heide S,Héron D,Depienne C,Titheradge H,Kramer JM,Campeau PM
G10362 was used in Immunoprecipitation to identify an NDD caused by SMARCD1 mutations and establish a role for the SMARCD1 ortholog Bap60 in the regulation of neurodevelopmental genes during a critical time window of juvenile adult brain development when neuronal circuits that are required for learning and memory are formed.
Thu Apr 04 00:00:00 UTC 2019
Cellular p32 Is a Critical Regulator of Porcine Circovirus Type 2 Nuclear Egress.
Journal of virology
Wang T,Du Q,Niu Y,Zhang X,Wang Z,Wu X,Yang X,Zhao X,Liu SL,Tong D,Huang Y
G10362 was used in Immunocytochemistry-immunoflourescence to demonstrate p32 as a critical regulator of PCV2 nuclear egress.
Sun Dec 01 00:00:00 UTC 2019
Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses.
Journal of virology
Albright BH,Simon KE,Pillai M,Devlin GW,Asokan A
G10362 was used in Immunohistochemistry to hypothesize that altered SIA-capsid interactions may influence the ability of AAV1RX to transduce the CNS.
Sat Jun 01 00:00:00 UTC 2019
Intrathecal Adeno-Associated Viral Vector-Mediated Gene Delivery for Adrenomyeloneuropathy.
Human gene therapy
Gong Y,Berenson A,Laheji F,Gao G,Wang D,Ng C,Volak A,Kok R,Kreouzis V,Dijkstra IM,Kemp S,Maguire CA,Eichler F
G10362 was used in Immunohistochemistry to report that slow intrathecal delivery of recombinant AAV serotype 9 (rAAV9) achieves efficient gene transfer across the spinal cord and dorsal root ganglia as demonstrated with two different transgenes, GFP and ABCD1.
Wed May 01 00:00:00 UTC 2019
The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.
Cellular microbiology
Kudyba HM,Cobb DW,Fierro MA,Florentin A,Ljolje D,Singh B,Lucchi NW,Muralidharan V
G10362 was used in Immunoprecipitation to study the role of PfGRP170 in the regulation of asexual development in malaria parasites.
Sun Sep 01 00:00:00 UTC 2019
Coordination of protrusion dynamics within and between collectively migrating border cells by myosin II.
Molecular biology of the cell
Mishra AK,Mondo JA,Campanale JP,Montell DJ
G10362 was used in Immunohistochemistry-immunofluorescence to show collectively migrating cells undergo protrusion dynamics mediated by dynamic pools of myosin II.
Sun Sep 01 00:00:00 UTC 2019
Reduced ΔFosB expression in the rat nucleus accumbens has causal role in the neuropathic pain phenotype.
Neuroscience letters
Pollema-Mays SL,Centeno MV,Chang Z,Apkarian AV,Martina M
G10362 was used in Immunohistochemistry to investigate if nucleus accumbens expression of ΔFos-B is reduced long term following peripheral neuropathic injury.
Wed May 29 00:00:00 UTC 2019
A scalable platform for the development of cell-type-specific viral drivers.
eLife
Hrvatin S,Tzeng CP,Nagy MA,Stroud H,Koutsioumpa C,Wilcox OF,Assad EG,Green J,Harvey CD,Griffith EC,Greenberg ME
G10362 was used in In vitro Assay to demonstrate the utility of this platform for developing new cell-type-specific viral reagents, with significant implications for both basic and translational research.
Mon Sep 23 00:00:00 UTC 2019
Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in vivo.
Development (Cambridge, England)
Lybrand DB,Naiman M,Laumann JM,Boardman M,Petshow S,Hansen K,Scott G,Wehrli M
G10362 was used in Immunohistochemistry to suggest a novel mechanistic model for dynamic Wnt signal transduction in vivo.
Tue Jul 02 00:00:00 UTC 2019
Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates.
PloS one
Ellsworth JL,Gingras J,Smith LJ,Rubin H,Seabrook TA,Patel K,Zapata N,Olivieri K,O'Callaghan M,Chlipala E,Morales P,Seymour A
G10362 was used in Immunohistochemistry to demonstrate that AAVHSCs have broad tissue tropism and cross the blood-nerve and blood-barriers following systemic delivery in nonhuman primates.
Mon Mar 23 00:00:00 UTC 2020
Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies.
G3 (Bethesda, Md.)
Shih MM,Davis FP,Henry GL,Dubnau J
G10362 was used in Sample Preparation to provide a full accounting of the neurotransmitter receptors, transporters, neurotransmitter biosynthetic enzymes, neuropeptides, and neuropeptide receptors expressed within each of these cell types.
Wed Jan 09 00:00:00 UTC 2019
Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse.
PloS one
Guo X,Liu Y,Kim JL,Kim EY,Kim EQ,Jansen A,Li K,Chan M,Keenan BT,Conejo-Garcia J,Lim DC
G10362 was used in Immunohistochemistry to investigate the effects of cyclical intermittent hypoxia on lung cancer progression and metastatic profile in a mouse model.
Mon Nov 25 00:00:00 UTC 2019
JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress.
eLife
Cosolo A,Jaiswal J,Csordás G,Grass I,Uhlirova M,Classen AK
G10362 was used in Immunohistochemistry-immunofluorescence to demonstrate that JNK signalling induces a dose-dependent extension of G2 in tissue damage and tumours, resulting in either transient stalling or a prolonged but reversible cell cycle arrest.
Fri Feb 08 00:00:00 UTC 2019
Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.
Molecular therapy. Methods & clinical development
Prabhakar S,Cheah PS,Zhang X,Zinter M,Gianatasio M,Hudry E,Bronson RT,Kwiatkowski DJ,Stemmer-Rachamimov A,Maguire CA,Sena-Esteves M,Tannous BA,Breakefield XO
G10362 was used in Immunohistochemistry to demonstrate that a single intravenous administration of an adeno-associated virus (AAV) vector encoding hamartin restored protein function in enough cells in the brain to extend lifespan in a TSC1 mouse model.
Fri Dec 13 00:00:00 UTC 2019
Enabling cell-type-specific behavioral epigenetics in Drosophila: a modified high-yield INTACT method reveals the impact of social environment on the epigenetic landscape in dopaminergic neurons.
BMC biology
Agrawal P,Chung P,Heberlein U,Kent C
G10362 was used in Chromatin immunoprecipitation to identify epigenetic signatures in socially isolated and socially enriched Drosophila males.
Wed Apr 10 00:00:00 UTC 2019
Distinct progenitor populations mediate regeneration in the zebrafish lateral line.
eLife
Thomas ED,Raible DW
G10362 was used in Immunohistochemistry to identify support cell populations with distinct progenitor identities.
Tue Mar 05 00:00:00 UTC 2019
Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing.
Nature neuroscience
Renthal W,Boxer LD,Hrvatin S,Li E,Silberfeld A,Nagy MA,Griffith EC,Vierbuchen T,Greenberg ME
G10362 was used in Chromatin immunoprecipitation to present a single-nucleus RNA sequencing approach that resolves mosaicism by using single-nucleotide polymorphisms in genes expressed in cis with the X-linked mutation to determine which nuclei express the mutant allele even when the mutant gene is not detected.
Sat Dec 01 00:00:00 UTC 2018
Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development.
Molecular psychiatry
Dang T,Duan WY,Yu B,Tong DL,Cheng C,Zhang YF,Wu W,Ye K,Zhang WX,Wu M,Wu BB,An Y,Qiu ZL,Wu BL
G10362 was used in Immunohistochemistry-immunofluorescence to demonstrate that the dose of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A protein has a crucial role in various aspects of postnatal neural development.
Thu Mar 01 00:00:00 UTC 2018
Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS.
Molecular therapy : the journal of the American Society of Gene Therapy
Naidoo J,Stanek LM,Ohno K,Trewman S,Samaranch L,Hadaczek P,O'Riordan C,Sullivan J,San Sebastian W,Bringas JR,Snieckus C,Mahmoodi A,Mahmoodi A,Forsayeth J,Bankiewicz KS,Shihabuddin LS
G10362 was used in Immunohistochemistry-immunofluorescence to emonstrate that AAV2-HBKO is a powerful vector for the potential treatment of a wide number of neurological disorders, and highlight that delivery route can significantly impact cellular tropism and pattern of CNS transduction.
Wed Oct 03 00:00:00 UTC 2018
Foxtail mosaic virus: A Viral Vector for Protein Expression in Cereals.
Plant physiology
Bouton C,King RC,Chen H,Azhakanandam K,Bieri S,Hammond-Kosack KE,Kanyuka K
G10362 was used in Immunohistochemistry-immunofluorescence to show how the studied VOX vector opens possibilities for functional genomics studies in two important cereal crops.
Wed Aug 01 00:00:00 UTC 2018
β-Catenin maintains lung epithelial progenitors after lung specification.
Development (Cambridge, England)
Ostrin EJ,Little DR,Gerner-Mauro KN,Sumner EA,Ríos-Corzo R,Ambrosio E,Holt SE,Forcioli-Conti N,Akiyama H,Hanash SM,Kimura S,Huang SXL,Chen J
G10362 was used in Immunoprecipitation to study how SRY box 9-expressing lung epithelial progenitors are maintained following specification within the embryonic foregut.
Fri Mar 09 00:00:00 UTC 2018
Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation.
Journal of virology
Wang T,Du Q,Wu X,Niu Y,Guan L,Wang Z,Zhao X,Liu SL,Tong D,Huang Y
G10362 was used in Western Blotting to characterise a putative porcine Makorin RING finger protein 1 variant, an N-terminal-truncated variant of putative full-size porcine MKRN1 which has a unique expression pattern resulting from the porcine mkrn1 gene and which interacts with PCV2 Cap.
Fri Jun 01 00:00:00 UTC 2018
Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP.
Biochemical and biophysical research communications
Adams A,Weinman SA,Wozniak AL
G10362 was used in Western Blotting to describe a mechanism by which cleavage of the Rab7 adaptor protein, Rab interacting lysosomal protein is induced by viral infection.
Tue Sep 18 00:00:00 UTC 2018
t-GRASP, a targeted GRASP for assessing neuronal connectivity.
Journal of neuroscience methods
Shearin HK,Quinn CD,Mackin RD,Macdonald IS,Stowers RS
G10362 was used in Immunohistochemistry to present tGRASP, a novel targeted GRASP method for neural circuit mapping in Drosophila.
Wed Aug 01 00:00:00 UTC 2018
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Frontiers in cellular neuroscience
Shaib AH,Staudt A,Harb A,Klose M,Shaaban A,Schirra C,Mohrmann R,Rettig J,Becherer U
G10362 was used in Immunocytochemistry-immunoflourescence to study whether the two paralogs of the calcium-dependent activator protein for secretion, regulate exocytosis of synaptic vesicles and large dense-core vesicles differentially in dorsal root ganglion neurons.
Sun Mar 31 00:00:00 UTC 2024
Mushroom Body Specific Transcriptome Analysis Reveals Dynamic Regulation of Learning and Memory Genes After Acquisition of Long-Term Courtship Memory in Drosophila.
G3 (Bethesda, Md.)
Jones SG,Nixon KCJ,Chubak MC,Kramer JM
G10362 was used in Immunoprecipitation to analyse the transcriptome of the Drosophila mushroom body at two points following the acquisition of long-term memory.
Tue Nov 06 00:00:00 UTC 2018
Expansion of functional personalized cells with specific transgene combinations.
Nature communications
Lipps C,Klein F,Wahlicht T,Seiffert V,Butueva M,Zauers J,Truschel T,Luckner M,Köster M,MacLeod R,Pezoldt J,Hühn J,Yuan Q,Müller PP,Kempf H,Zweigerdt R,Dittrich-Breiholz O,Pufe T,Beckmann R,Drescher W,Riancho J,Sañudo C,Korff T,Opalka B,Rebmann V,Göthert JR,Alves PM,Ott M,Schucht R,Hauser H,Wirth D,May T
G10362 was used in Immunohistochemistry to develop a novel strategy for rapid, functional, personalised cell expansion.
Thu Mar 08 00:00:00 UTC 2018
Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles.
Nature communications
Wentzel C,Delvendahl I,Sydlik S,Georgiev O,Müller M
G10362 was used in Immunohistochemistry to suggest that presynaptic protein degradation opposes the release of low-release probability vesicles that are potentiated during homeostatic plasticity and controlled by dysbindin.
Thu Jan 18 00:00:00 UTC 2018
Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus.
The Journal of physiology
Anstötz M,Lee SK,Maccaferri G
G10362 was used in Immunocytochemistry-immunofluorescence to propose that functional TRPV1 receptors may be related to mechanisms involved in CR progressive reduction by calcium-dependent toxicity/apoptosis.
Wed Aug 01 00:00:00 UTC 2018
Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.
Nature communications
Cho YS,Zhu J,Li S,Wang B,Han Y,Jiang J
G10362 was used in Immunoprecipitation to further explore Hpo pathway regulation and suggest PRP4K-mediated Yki/Yap phosphorylation in the nucleus restricts aberrant pathway activation.
Wed Apr 25 00:00:00 UTC 2018
Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture.
PLoS genetics
Donohoe CD,Csordás G,Correia A,Jindra M,Klein C,Habermann B,Uhlirova M
G10362 was used in Immunohistochemistry-immunofluorescence to elucidate the role of Drosophila activating transcription factor 3 as a cell polarity response gene acting downstream of the membrane-associated Scribble polarity complex.
Thu Mar 01 00:00:00 UTC 2018
Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex.
Cell
Murugan M,Jang HJ,Park M,Miller EM,Cox J,Taliaferro JP,Parker NF,Bhave V,Hur H,Liang Y,Nectow AR,Pillow JW,Witten IB
G10362 was used in Immunohistochemistry to study the contribution of social and spatial information within the prelimbic cortex-nucleus accumbens to social behaviour by supporting social-spatial learning.
Thu Dec 14 00:00:00 UTC 2017
Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.
Cell
Stroud H,Su SC,Hrvatin S,Greben AW,Renthal W,Boxer LD,Nagy MA,Hochbaum DR,Kinde B,Gabel HW,Greenberg ME
G10362 was used in Immunoprecipitation to show that in the brain during early life, the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences within these genes.
Thu Nov 16 00:00:00 UTC 2017
Mast cell hyperactivity underpins the development of oxygen-induced retinopathy.
The Journal of clinical investigation
Matsuda K,Okamoto N,Kondo M,Arkwright PD,Karasawa K,Ishizaka S,Yokota S,Matsuda A,Jung K,Oida K,Amagai Y,Jang H,Noda E,Kakinuma R,Yasui K,Kaku U,Mori Y,Onai N,Ohteki T,Tanaka A,Matsuda H
G10362 was used in Immunohistochemistry to demonstrate that mast cells are essential for sprouting angiogenesis in a murine model of oxygen-induced retinopathy.
Wed Nov 01 00:00:00 UTC 2017
Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin.
Molecular therapy. Nucleic acids
Pfister EL,Chase KO,Sun H,Kennington LA,Conroy F,Johnson E,Miller R,Borel F,Aronin N,Mueller C
G10362 was used in Immunohistochemistry to demonstrate that miRNA backbone and promoter can be used together to modulate expression levels and strand selection of artificial miRNAs.
Fri Jun 16 00:00:00 UTC 2017
Intracranial AAV-IFN-β gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model.
Molecular oncology
GuhaSarkar D,Neiswender J,Su Q,Gao G,Sena-Esteves M
G10362 was used in Immunohistochemistry to demonstrate the therapeutic potential of intracranial adeno-associated viral vectors (AAV)-interferon-beta (IFN-Β) therapy in a syngeneic mouse model, and that combination with temozolomide is likely to enhance its antitumour potency.
Wed Feb 01 00:00:00 UTC 2017
Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear.
Frontiers in molecular neuroscience
Sato MP,Higuchi T,Nin F,Ogata G,Sawamura S,Yoshida T,Ota T,Hori K,Komune S,Uetsuka S,Choi S,Masuda M,Watabe T,Kanzaki S,Ogawa K,Inohara H,Sakamoto S,Takebayashi H,Doi K,Tanaka KF,Hibino H
G10362 was used in Western Blotting to study the induction and control of hearing loss through stimulation of different non-excitable cell types in the cochlea of the inner ear.
Thu Oct 01 00:00:00 UTC 2020
Skeletal myofiber vascular endothelial growth factor is required for the exercise training-induced increase in dentate gyrus neuronal precursor cells.
The Journal of physiology
Rich B,Scadeng M,Yamaguchi M,Wagner PD,Breen EC
G10362 was used in Immunohistochemistry-immunofluorescence to elucidate the mechanisms by which exercise, through skeletal myofibre vascular endothelial growth factor, affects the hippocampus.
Fri Sep 01 00:00:00 UTC 2017
Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation.
Journal of cell science
Hiroyasu S,Stimac GP,Hopkinson SB,Jones JCR
G10362 was used in Western Blot to study the functions of the guanine nucleotide exchange factor β-PIX.
Sat Jul 15 00:00:00 UTC 2017
Lgr6 is dispensable for epidermal cell proliferation and wound repair.
Experimental dermatology
Jiang L,Wang L,Chen CP,Li MQ,Liao XH
G10362 was used in immunohistochemistry to show that Lgr6 is dispensable for epidermal cell proliferation and wound repair
Wed Feb 01 00:00:00 UTC 2017
Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS.
Neuroscience
Li D,Liu C,Yang C,Wang D,Wu D,Qi Y,Su Q,Gao G,Xu Z,Guo Y
G10362 was used in Immunohistochemistry to demonstrate that intrathecal injection speed influences the predominance of gene delivery at different central nervous system sites.
Mon Dec 04 00:00:00 UTC 2017
Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.
The European journal of neuroscience
Nagy JI,Rash JE
G10362 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to examine localization relationships of these connexins with each other and with glial connexin43.
Sat Jul 01 00:00:00 UTC 2017
Contribution of minced muscle graft progenitor cells to muscle fiber formation after volumetric muscle loss injury in wild-type and immune deficient mice.
Physiological reports
Corona BT,Henderson BE,Ward CL,Greising SM
G10362 was used in Immunohistochemistry to establish a volumetric muscle injury (VML) model to test the hypothesis that minced muscle grafts promote muscle fiber regeneration after VML injury.
Sat Apr 01 00:00:00 UTC 2017
Thermostable exoshells fold and stabilize recombinant proteins.
Nature communications
Deshpande S,Masurkar ND,Girish VM,Desai M,Chakraborty G,Chan JM,Drum CL
G10362 was used in Western blotting to develop a thermostable protein nanoparticle to improve both expression and stabilisation of recombinant proteins.
Mon Nov 13 00:00:00 UTC 2017
Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice.
Nature medicine
Rozo M,Li L,Fan CM
G10362 was used in immunocytochemistry to explore how the interaction between beta1-integrin and Fgf2 contributes to the satellite cell niche
Mon Aug 01 00:00:00 UTC 2016
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.
Circulation
Dubrac A,Genet G,Ola R,Zhang F,Pibouin-Fragner L,Han J,Zhang J,Thomas JL,Chedotal A,Schwartz MA,Eichmann A
G10362 was used in Western Blotting to demonstrate the requirement of Nck adaptors for endothelial cell front-rear polarity and migration downstream of the angiogenic growth factors, VEGF-A and Slit2.
Tue Jan 26 00:00:00 UTC 2016
Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma.
Neuro-oncology
GuhaSarkar D,Su Q,Gao G,Sena-Esteves M
G10362 was used in immunohistochemistry - paraffin section to study the treatment of highly invasive glioblastoma due to systemic AAV9-IFN-beta gene delivery
Tue Nov 01 00:00:00 UTC 2016
Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector.
Molecular therapy : the journal of the American Society of Gene Therapy
Choudhury SR,Harris AF,Cabral DJ,Keeler AM,Sapp E,Ferreira JS,Gray-Edwards HL,Johnson JA,Johnson AK,Su Q,Stoica L,DiFiglia M,Aronin N,Martin DR,Gao G,Sena-Esteves M
G10362 was used in Immunohistochemistry to investigate the possibility of improving CNS transduction of existing adeno-associated virus capsids by genetically fusing peptides to the N-terminus of VP2 capsid protein.
Fri Apr 01 00:00:00 UTC 2016
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Choudhury SR,Fitzpatrick Z,Harris AF,Maitland SA,Ferreira JS,Zhang Y,Ma S,Sharma RB,Gray-Edwards HL,Johnson JA,Johnson AK,Alonso LC,Punzo C,Wagner KR,Maguire CA,Kotin RM,Martin DR,Sena-Esteves M
G10362 was used in Immunohistochemistry to identify a novel central nervous system tropic adeno-associated viral capsid for central nervous system and muscle gene therapy.
Mon Aug 01 00:00:00 UTC 2016
DNA demethylation is initiated in the central cells of Arabidopsis and rice.
Proceedings of the National Academy of Sciences of the United States of America
Park K,Kim MY,Vickers M,Park JS,Hyun Y,Okamoto T,Zilberman D,Fischer RL,Feng X,Choi Y,Scholten S
G10362 was used in Immunoprecipitation to demonstrate that locus-specific, active DNA demethylation in the central cell is the origin of maternal chromosome hypomethylation in the endosperm.
Tue Dec 27 00:00:00 UTC 2016
CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector.
Molecular therapy. Nucleic acids
Murlidharan G,Sakamoto K,Rao L,Corriher T,Wang D,Gao G,Sullivan P,Asokan A
G10362 was used in immunohistochemistry to generate and characterize an adeno-associated viral chimera
Tue Jul 19 00:00:00 UTC 2016
Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.
Development (Cambridge, England)
Yabe T,Hoshijima K,Yamamoto T,Takada S
G10362 was used in Immunohistochemistry-wholemount to observe the conserved and species-specific roles of Mesp in the link between molecular clock and somite morphogenesis, across mice and zebrafish.
Mon Aug 01 00:00:00 UTC 2016
Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model.
Molecular therapy oncolytics
Crommentuijn MH,Kantar R,Noske DP,Vandertop WP,Badr CE,Würdinger T,Maguire CA,Tannous BA
G10362 was used in immunohistochemistry - free floating to evaluate adeno-associated virus 9 for potential glioblastoma therapy
Wed Jul 06 00:00:00 UTC 2016
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
Biology open
Dutta N,Seo S
G10362 was used in Immunocytochemistry to examine an alternative relationship between retinitis pigmentosa GTPase regulator and PDE6D.
Thu Sep 15 00:00:00 UTC 2016
Production of bioactive wheat puroindoline proteins in Nicotiana benthamiana using a virus-based transient expression system.
Protein expression and purification
Niknejad A,Webster D,Bhave M
G10362 was used in western blot to investigate puroindoline A and B functionality.
Thu Sep 01 00:00:00 UTC 2016
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain.
JCI insight
Murlidharan G,Crowther A,Reardon RA,Song J,Asokan A
G10362 was used in Immunohistochemistry to demonstrate that glymphatic transport profoundly affects various aspects of adeno-associated viruse gene transfer in the CNS.
Thu Sep 08 00:00:00 UTC 2016
Monitoring Wnt/β-Catenin Signaling in Skin.
Methods in molecular biology (Clifton, N.J.)
Ku AT,Miao Q,Nguyen H
G10362 was used in immunohistochemistry to review methods to detect Wnt/beta-catenin signaling in the skin
Mon Jan 15 00:00:00 UTC 2018
Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor α1S Subunit Reveals Conformational Differences Induced by Binding of the β1a Subunit.
The Journal of biological chemistry
Mahalingam M,Perez CF,Fessenden JD
G10362 was used in Immunocytochemistry to characterise the relative proximity of the cytoplasmic loops in α1S subunits expressed in intact cells.
Fri Jun 24 00:00:00 UTC 2016
Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model.
BMC ophthalmology
Cho SH,Song JY,Shin J,Kim S
G10362 was used in immunohistochemistry to use an LCA8-like mouse model to find host-mediated responses that reduce survival, retinal integration, and differentiation of grafted cells during neonatal cell therapy
Fri Nov 04 00:00:00 UTC 2016
Simple and Effective Affinity Purification Procedures for Mass Spectrometry-Based Identification of Protein-Protein Interactions in Cell Signaling Pathways.
Methods in molecular biology (Clifton, N.J.)
Kwan JHM,Emili A
G10362 was used in immunoprecipitation to study mass spectrometry-based identification of protein-protein interactions in cell signaling pathways through simple and effective affinity purification procedures
Thu Oct 13 00:00:00 UTC 2016
Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.
Cell death & disease
Valenzuela R,Costa-Besada MA,Iglesias-Gonzalez J,Perez-Costas E,Villar-Cheda B,Garrido-Gil P,Melendez-Ferro M,Soto-Otero R,Lanciego JL,Henrion D,Franco R,Labandeira-Garcia JL
G10362 was used in Western Blotting to identify angiotensin type 1 and 2 receptors in brain mitochondria, and investigate their role in cell protection and ageing-related vulnerability to neurodegeneration.
Thu Oct 20 00:00:00 UTC 2016
G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis.
Stem cell reports
Olsen JB,Wong L,Deimling S,Miles A,Guo H,Li Y,Zhang Z,Greenblatt JF,Emili A,Tropepe V
G10362 was used in immunoprecipitation to report that ZNF644 is a co-regulator of G9a/H3K9me2-mediated gene silencing during neuronal differentiation
Tue Sep 13 00:00:00 UTC 2016
Optogenetic approaches addressing extracellular modulation of neural excitability.
Scientific reports
Ferenczi EA,Vierock J,Atsuta-Tsunoda K,Tsunoda SP,Ramakrishnan C,Gorini C,Thompson K,Lee SY,Berndt A,Perry C,Minniberger S,Vogt A,Mattis J,Prakash R,Delp S,Deisseroth K,Hegemann P
G10362 was used in Immunohistochemistry to present a new approach to the engineering of multicomponent optogenetic tools to manipulate ionic microdomains and probe the interactions regulating neural excitability.
Tue Apr 05 00:00:00 UTC 2016
High-performance probes for light and electron microscopy.
Nature methods
Viswanathan S,Williams ME,Bloss EB,Stasevich TJ,Speer CM,Nern A,Pfeiffer BD,Hooks BM,Li WP,English BP,Tian T,Henry GL,Macklin JJ,Patel R,Gerfen CR,Zhuang X,Wang Y,Rubin GM,Looger LL
G10362 was used in immunohistochemistry to develop and characterize 'spaghetti monster' fluorescent proteins
Mon Jun 01 00:00:00 UTC 2015
A versatile modular vector system for rapid combinatorial mammalian genetics.
The Journal of clinical investigation
Albers J,Danzer C,Rechsteiner M,Lehmann H,Brandt LP,Hejhal T,Catalano A,Busenhart P,Gonçalves AF,Brandt S,Bode PK,Bode-Lesniewska B,Wild PJ,Frew IJ
G10362 was used in immunocytochemistry to describe the multiple lentiviral expression (MuLE) system that allows multiple genetic alterations to be introduced simultaneously into mammalian cells
Wed Apr 01 00:00:00 UTC 2015
Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses.
Neuroscience
Rubio ME,Nagy JI
G10362 was used in immunohistochemistry to assess Cx36 expression in the cochlear nucleus and in various structures of the auditory pathway of rat and mouse.
Thu Sep 10 00:00:00 UTC 2015
Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies.
Bone
Sanches PG,Peters S,Rossin R,Kaijzel EL,Que I,Löwik CW,Grüll H
G10362 was used in immunohistochemistry to characterize a mouse model of osteolytic metastatic bone tumors using SPECT/CT and MRI
Mon Jun 01 00:00:00 UTC 2015
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Nature communications
Aspalter IM,Gordon E,Dubrac A,Ragab A,Narloch J,Vizán P,Geudens I,Collins RT,Franco CA,Abrahams CL,Thurston G,Fruttiger M,Rosewell I,Eichmann A,Gerhardt H
G10362 was used in Immunohistochemistry to demonstrate that Notch downregulates Nrp1, thus relieving the inhibition of Alk1 and Alk5, thereby driving stalk-cell behaviour.
Wed Jun 17 00:00:00 UTC 2015
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis.
Nature
Ouyang H,Xue Y,Lin Y,Zhang X,Xi L,Patel S,Cai H,Luo J,Zhang M,Zhang M,Yang Y,Li G,Li H,Jiang W,Yeh E,Lin J,Pei M,Zhu J,Cao G,Zhang L,Yu B,Chen S,Fu XD,Liu Y,Zhang K
G10362 was used in immunocytochemistry to establish an in vitro system to study three-dimensional corneal differentiation
Thu Jul 17 00:00:00 UTC 2014
3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions.
Cell
Lucas JS,Zhang Y,Dudko OK,Murre C
G10362 was used in Immunohistochemistry to mark the distal VH and DH-JH-Eμ regions with Tet-operator binding sites and trace their 3D trajectories in pro-B cells transduced with a retrovirus encoding Tet-repressor-EGFP.
Thu Jul 17 00:00:00 UTC 2014
Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity.
Neuron
Wang T,Hauswirth AG,Tong A,Dickman DK,Davis GW
G10362 was used in Immunocytochemistry to demonstrate that Multiplexin is required for normal calcium channel abundance, presynaptic calcium influx, and neurotransmitter release in Drosophila.
Wed Aug 06 00:00:00 UTC 2014
Advanced CLARITY for rapid and high-resolution imaging of intact tissues.
Nature protocols
Tomer R,Ye L,Hsueh B,Deisseroth K
G10362 was used in Immunohistochemistry to develop an advanced CLARITY protocol for rapid and high-resolution imaging of intact tissues.
Tue Jul 01 00:00:00 UTC 2014
RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease.
Neurobiology of disease
Wang R,Palavicini JP,Wang H,Maiti P,Bianchi E,Xu S,Lloyd BN,Dawson-Scully K,Kang DE,Lakshmana MK
G10362 was used in Immunohistochemistry to demonstrate that RanBP9 might play a crucial role in the loss of spines and synapses in Alzheimer's disease.
Mon Sep 01 00:00:00 UTC 2014
Optogenetic activation of cajal-retzius cells reveals their glutamatergic output and a novel feedforward circuit in the developing mouse hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Quattrocolo G,Maccaferri G
G10362 was used in Immunocytochemistry-immunoflourescence to indicate that Cajal-Retzius cells form a novel glutamatergic microcircuit in the hippocampus.
Wed Sep 24 00:00:00 UTC 2014
Munc13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ishiyama S,Schmidt H,Cooper BH,Brose N,Eilers J
G10362 was used in immunohistochemistry to use Munc13-3(-/-) mice to study the release probability of vesicles
Wed Oct 29 00:00:00 UTC 2014
POPX2 phosphatase regulates cell polarity and centrosome placement.
Cell cycle (Georgetown, Tex.)
Hoon JL,Li HY,Koh CG
G10362 was used in Immunohistochemistry-immunofluorescence to investigate the regulation of centrosome polarisation and identify POPX2 as an important regulator of centrosome orientation.
Thu Aug 13 00:00:00 UTC 2015
ORF7-encoded accessory protein 7a of feline infectious peritonitis virus as a counteragent against IFN-α-induced antiviral response.
The Journal of general virology
Dedeurwaerder A,Olyslaegers DAJ,Desmarets LMB,Roukaerts IDM,Theuns S,Nauwynck HJ
Sat Feb 01 00:00:00 UTC 2014
Hexameric GFP and mCherry reporters for the Drosophila GAL4, Q, and LexA transcription systems.
Genetics
Shearin HK,Macdonald IS,Spector LP,Stowers RS
Tue Apr 01 00:00:00 UTC 2014
Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse.
The European journal of neuroscience
Bautista W,Nagy JI
G10362 was used in immunocytochemistry to identify gap junction-mediated communcation between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse
Sat Mar 01 00:00:00 UTC 2014
AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations.
Journal of neuroscience methods
Alves JN,Muir EM,Andrews MR,Ward A,Michelmore N,Dasgupta D,Verhaagen J,Moloney EB,Keynes RJ,Fawcett JW,Rogers JH
G10362 was used in immunohistochemistry - frozen section to characterize the expression of chondroitinase ABC delivery by an adenovirus vector to the central nervous system
Wed Apr 30 00:00:00 UTC 2014
Cecal ligation and puncture-induced sepsis as a model to study autophagy in mice.
Journal of visualized experiments : JoVE
Siempos II,Lam HC,Ding Y,Choi ME,Choi AM,Ryter SW
G10362 was used in immunohistochemistry - paraffin section to study autophagic responses to sepsis.
Sun Feb 09 00:00:00 UTC 2014
FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.
Genes & development
Takase HM,Itoh T,Ino S,Wang T,Koji T,Akira S,Takikawa Y,Miyajima A
G10362 was used in immunohistochemistry to investigate liver progenitor cell activation.
Tue Jan 15 00:00:00 UTC 2013
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen Z,Cooper B,Kalla S,Varoqueaux F,Young SM
Wed May 08 00:00:00 UTC 2013
Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells.
Biology of reproduction
Peluso JJ,Yuan A,Liu X,Lodde V
Tue Jan 01 00:00:00 UTC 2013
Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells.
Biology of reproduction
Peluso JJ,Yuan A,Liu X,Lodde V
Tue Jan 01 00:00:00 UTC 2013
c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
PloS one
Webster MT,Fan CM
G10362 was used in immunocytochemistry to study how adult skeletal muscle regeneration uses c-Met regulation of myoblast motility and myocyte fusion
Mon Jun 30 00:00:00 UTC 2014
The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration.
The Journal of biological chemistry
Parsons B,Foley E
G10362 was used in immunohistochemistry to determine Pvf2 and Pvf3 functions in vivo using fruit flies.
Fri Jul 12 00:00:00 UTC 2013
Cell type-specific genomics of Drosophila neurons.
Nucleic acids research
Henry GL,Davis FP,Picard S,Eddy SR
Mon Oct 01 00:00:00 UTC 2012
Identification of modulators of hair cell regeneration in the zebrafish lateral line.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Namdaran P,Reinhart KE,Owens KN,Raible DW,Rubel EW
G10362 was used in immunohistochemistry to investigate compounds that modulate hair cell regeneration in zebrafish.
Wed Mar 07 00:00:00 UTC 2012
The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2α.
Journal of virology
Van Opdenbosch N,Van den Broeke C,De Regge N,Tabarés E,Favoreel HW
Sun Jul 01 00:00:00 UTC 2012
Systematic single-cell analysis of Pichia pastoris reveals secretory capacity limits productivity.
PloS one
Love KR,Politano TJ,Panagiotou V,Jiang B,Stadheim TA,Love JC
Fri Dec 07 00:00:00 UTC 2012
A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins.
Nature methods
Kleinlogel S,Terpitz U,Legrum B,Gökbuget D,Boyden ES,Bamann C,Wood PG,Bamberg E
G10362 was used in immunohistochemistry - frozen section to develop a gene-fusion strategy for the stable 1:1 expression of any two microbial rhodopsins in a single polypeptide chain
Sun Nov 06 00:00:00 UTC 2011
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Nature cell biology
Calvo F,Sanz-Moreno V,Agudo-Ibáñez L,Wallberg F,Sahai E,Marshall CJ,Crespo P
Sun Jun 19 00:00:00 UTC 2011
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Nature cell biology
Calvo F,Sanz-Moreno V,Agudo-Ibáñez L,Wallberg F,Sahai E,Marshall CJ,Crespo P
Sun Jun 19 00:00:00 UTC 2011
An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration.
Development (Cambridge, England)
Lepper C,Partridge TA,Fan CM
Thu Sep 01 00:00:00 UTC 2011
BID-F1 and BID-F2 domains of Bartonella henselae effector protein BepF trigger together with BepC the formation of invasome structures.
PloS one
Truttmann MC,Guye P,Dehio C
Fri Apr 06 00:00:00 UTC 2012
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
PLoS genetics
Seo S,Zhang Q,Bugge K,Breslow DK,Searby CC,Nachury MV,Sheffield VC
Tue Nov 01 00:00:00 UTC 2011
ColQ controls postsynaptic differentiation at the neuromuscular junction.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sigoillot SM,Bourgeois F,Lambergeon M,Strochlic L,Legay C
Wed Jan 06 00:00:00 UTC 2010
Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.
Molecular therapy : the journal of the American Society of Gene Therapy
Dalkara D,Kolstad KD,Caporale N,Visel M,Klimczak RR,Schaffer DV,Flannery JG
Tue Dec 01 00:00:00 UTC 2009
