Product References
The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA.
Viruses
Shi Y,Simpson S,Ahmed SK,Chen Y,Tavakoli-Tameh A,Janaka SK,Evans DT,Serra-Moreno R
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Wed Sep 20 00:00:00 UTC 2023
Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration.
Nature communications
Chang YH,Dubnau J
MA5-15256 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot to demonstrate that endogenous retrovirus (ERV) expression and TDP-43 proteinopathy are mutually reinforcing.
Tue Feb 21 00:00:00 UTC 2023
Longitudinal visceral muscles in Drosophila fully dedifferentiate and fragment prior to their reestablishment during metamorphosis.
microPublication biology
Schultheis D,Frasch M
MA5-15256 was used in Immunohistochemistry to present our independent analysis using HLH54Fb-eGFP as a cell type specific marker, which strengthens the proposition by Aghajanian et al.
Tue Apr 04 00:00:00 UTC 2023
Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans.
PLoS biology
Zhao Q,Rangan R,Weng S,Özdemir C,Sarinay Cenik E
MA5-15256 was used in Western Blotting to suggest a novel mechanism of nutrition-independent multicellular growth coordination initiated from the epidermis tissue upon ribosome biogenesis inhibition.
Tue Aug 01 00:00:00 UTC 2023
Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling.
The Journal of biological chemistry
Adams LM,DeHart CJ,Drown BS,Anderson LC,Bocik W,Boja ES,Hiltke TM,Hendrickson CL,Rodriguez H,Caldwell M,Vafabakhsh R,Kelleher NL
MA5-15256 was used in Western Blot to provide a reference set of functionally distinct KRAS proteoforms and the colorectal cancer contexts in which they are present.
Sun Jan 01 00:00:00 UTC 2023
Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations.
Frontiers in cell and developmental biology
Mao Z,Nakamura F
MA5-15256 was used in Western Blotting to demonstrate that the LARP4 interaction with FLNA regulates cell migration.
Sun May 14 00:00:00 UTC 2023
Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
Bioscience reports
Fernando SJA,Wang Q,Hay DL,Bathgate RAD,Shepherd PR,Lee KL
MA5-15256 was used in Western Blotting to develop a cell model using Colo320, a human gut-derived immortalised cell line that produces and releases serotonin.
Wed Apr 26 00:00:00 UTC 2023
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Molecular cell
Cosentino K,Hertlein V,Jenner A,Dellmann T,Gojkovic M,Peña-Blanco A,Dadsena S,Wajngarten N,Danial JSH,Thevathasan JV,Mund M,Ries J,Garcia-Saez AJ
MA5-15256 was used in Immunocytochemistry-immunoflourescence to report that BAX and BAK present distinct oligomerization properties, with BAK organizing into smaller structures with faster kinetics than BAX.
Thu Mar 03 00:00:00 UTC 2022
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
The EMBO journal
Kai F,Ou G,Tourdot RW,Stashko C,Gaietta G,Swift MF,Volkmann N,Long AF,Han Y,Huang HH,Northey JJ,Leidal AM,Viasnoff V,Bryant DM,Guo W,Wiita AP,Guo M,Dumont S,Hanein D,Radhakrishnan R,Weaver VM
MA5-15256 was used in Western Blotting to implicate cortical actin tension-mediated filamin unfolding in ER function and underscore the importance of tissue mechanics in organoid homeostasis.
Thu Sep 01 00:00:00 UTC 2022
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
The EMBO journal
Kai F,Ou G,Tourdot RW,Stashko C,Gaietta G,Swift MF,Volkmann N,Long AF,Han Y,Huang HH,Northey JJ,Leidal AM,Viasnoff V,Bryant DM,Guo W,Wiita AP,Guo M,Dumont S,Hanein D,Radhakrishnan R,Weaver VM
MA5-15256 was used in Western Blotting to implicate cortical actin tension-mediated filamin unfolding in ER function and underscore the importance of tissue mechanics in organoid homeostasis.
Thu Sep 01 00:00:00 UTC 2022
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
The Journal of cell biology
Stormo AED,Shavarebi F,FitzGibbon M,Earley EM,Ahrendt H,Lum LS,Verschueren E,Swaney DL,Skibinski G,Ravisankar A,van Haren J,Davis EJ,Johnson JR,Von Dollen J,Balen C,Porath J,Crosio C,Mirescu C,Iaccarino C,Dauer WT,Nichols RJ,Wittmann T,Cox TC,Finkbeiner S,Krogan NJ,Oakes SA,Hiniker A
MA5-15256 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Flow Cytometry to suggest that TRIM1 is a critical regulator of LRRK2, controlling its degradation, localization, binding partners, kinase activity, and cytotoxicity.
Mon Apr 04 00:00:00 UTC 2022
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
The Journal of cell biology
Stormo AED,Shavarebi F,FitzGibbon M,Earley EM,Ahrendt H,Lum LS,Verschueren E,Swaney DL,Skibinski G,Ravisankar A,van Haren J,Davis EJ,Johnson JR,Von Dollen J,Balen C,Porath J,Crosio C,Mirescu C,Iaccarino C,Dauer WT,Nichols RJ,Wittmann T,Cox TC,Finkbeiner S,Krogan NJ,Oakes SA,Hiniker A
MA5-15256 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Flow Cytometry to suggest that TRIM1 is a critical regulator of LRRK2, controlling its degradation, localization, binding partners, kinase activity, and cytotoxicity.
Mon Apr 04 00:00:00 UTC 2022
Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pop IV,Espinosa F,Blevins CJ,Okafor PC,Ogujiofor OW,Goyal M,Mona B,Landy MA,Dean KM,Gurumurthy CB,Lai HC
MA5-15256 was used in Western Blotting to define the unique anatomic trajectories of long-range direct and indirect spinocerebellar pathways as well as local intersegmental spinal circuits using genetic tools in both male and female mice.
Wed Jan 26 00:00:00 UTC 2022
Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.
The Journal of reproduction and development
Wei YS,Lin WZ,Wang TE,Lee WY,Li SH,Lin FJ,Nixon B,Sipilä P,Tsai PS
MA5-15256 was used in Immunocytochemistry, Western Blot to show in mice that quiescin sulfhydryl oxidase 1 (QSOX1) protein expression and secretion are positively correlated with the presence of testosterone and sperm cells.
Wed Jun 01 00:00:00 UTC 2022
Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.
The Journal of reproduction and development
Wei YS,Lin WZ,Wang TE,Lee WY,Li SH,Lin FJ,Nixon B,Sipilä P,Tsai PS
MA5-15256 was used in Immunocytochemistry, Western Blot to show in mice that quiescin sulfhydryl oxidase 1 (QSOX1) protein expression and secretion are positively correlated with the presence of testosterone and sperm cells.
Wed Jun 01 00:00:00 UTC 2022
Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.
The Journal of reproduction and development
Wei YS,Lin WZ,Wang TE,Lee WY,Li SH,Lin FJ,Nixon B,Sipilä P,Tsai PS
MA5-15256 was used in Immunocytochemistry, Western Blot to show in mice that quiescin sulfhydryl oxidase 1 (QSOX1) protein expression and secretion are positively correlated with the presence of testosterone and sperm cells.
Wed Jun 01 00:00:00 UTC 2022
Herbivore-induced Ca2+ signals trigger a jasmonate burst by activating ERF16-mediated expression in tomato.
The New phytologist
Hu C,Wu S,Li J,Dong H,Zhu C,Sun T,Hu Z,Foyer CH,Yu J
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Thu Dec 01 00:00:00 UTC 2022
The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo.
Cells
Yap YT,Li W,Zhou Q,Haj-Diab S,Chowdhury DD,Vaishnav A,Harding P,Williams DC,Edwards BF,Strauss JF,Zhang Z
MA5-15256 was used in Western Blot to investigate the role of the ancient Spag6 gene.
Thu Jan 20 00:00:00 UTC 2022
The Ancient and Evolved Mouse Sperm-Associated Antigen 6 Genes Have Different Biologic Functions In Vivo.
Cells
Yap YT,Li W,Zhou Q,Haj-Diab S,Chowdhury DD,Vaishnav A,Harding P,Williams DC,Edwards BF,Strauss JF,Zhang Z
MA5-15256 was used in Western Blot to investigate the role of the ancient Spag6 gene.
Thu Jan 20 00:00:00 UTC 2022
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels.
Nature cell biology
Hao X,Shiromoto Y,Sakurai M,Towers M,Zhang Q,Wu S,Havas A,Wang L,Berger S,Adams PD,Tian B,Nishikura K,Kossenkov AV,Liu P,Zhang R
MA5-15256 was used in Western Blotting to reveal an RNA-editing-independent role for ADAR1 in the regulation of senescence by post-transcriptionally controlling p16INK4a expression.
Mon Aug 01 00:00:00 UTC 2022
SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly.
Nature communications
Vester SK,Rahikainen R,Khairil Anuar INA,Hills RA,Tan TK,Howarth M
MA5-15256 was used in Western Blotting to show that SpySwitch illustrates how proteins can become responsive to two distinct features of their environment, while generating a tool that should facilitate the use of Spy technology for empowering protein function.
Tue Jun 28 00:00:00 UTC 2022
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Cell
Puno MR,Lima CD
MA5-15256 was used in Western Blotting to determine cryogenic electron microscopy structures of human nuclear exosome targeting (NEXT) complexes bound to RNA that reveal mechanistic insights to substrate recognition and early steps that precede RNA handover to the exosome.
Thu Jun 09 00:00:00 UTC 2022
Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages.
International journal of molecular sciences
Behera A,Jain P,Ganguli G,Biswas M,Padhi A,Pattanaik KP,Nayak B,Ergün S,Hagens K,Redinger N,Saqib M,Mishra BB,Schaible UE,Karnati S,Sonawane A
MA5-15256 was used in Immunocytochemistry to show that peroxisomes represent interesting targets for host-directed therapeutics to tuberculosis.
Sat Feb 26 00:00:00 UTC 2022
Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages.
International journal of molecular sciences
Behera A,Jain P,Ganguli G,Biswas M,Padhi A,Pattanaik KP,Nayak B,Ergün S,Hagens K,Redinger N,Saqib M,Mishra BB,Schaible UE,Karnati S,Sonawane A
MA5-15256 was used in Immunocytochemistry to show that peroxisomes represent interesting targets for host-directed therapeutics to tuberculosis.
Sat Feb 26 00:00:00 UTC 2022
A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae.
Genetics
Hurst Z,Liu W,Shi Q,Herman PK
MA5-15256 was used in Western Blot to suggest that the disruption of microtubule integrity leads to the formation of a novel type of Processing-body granule that may have distinct biological activities in the cell.
Tue Aug 30 00:00:00 UTC 2022
Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells.
Frontiers in oncology
Yi J,Gong X,Yin XY,Wang L,Hou JX,Chen J,Xie B,Chen G,Wang LN,Wang XY,Wang DC,Wei HL
MA5-15256 was used in Western Blotting to find that parthenolide and arsenic trioxide co-treatment can synergistically inhibit the in vitro and in vivo proliferation activity of hepatocellular carcinoma cells through suppressing stemness and self-renewal ability, and inducing mitochondria-dependent apoptosis.
Fri Nov 11 00:00:00 UTC 2022
TLK1-mediated MK5-S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies.
Molecular oncology
Khalil MI,Singh V,King J,De Benedetti A
MA5-15256 was used in Immunoprecipitation to establish that TLK1 phosphorylates MK5 on three residues (S160, S354 and S386), resulting in MK5 activation, and additionally, mobility shifts of MK5 also supported its phosphorylation by TLK1 in transfected HEK 293 cells.
Fri Jul 01 00:00:00 UTC 2022
Depletion of Scleraxis-lineage cells during tendon healing transiently impairs multi-scale restoration of tendon structure during early healing.
PloS one
Korcari A,Muscat S,McGinn E,Buckley MR,Loiselle AE
MA5-15256 was used in Immunohistochemistry to study the spatiotemporal dynamics of ScxLin cells during tendon healing, and identified that the overall ScxLin pool continuously expands up to early remodeling healing phase.
Tue Oct 18 00:00:00 UTC 2022
A novel mouse model of CMT1B identifies hyperglycosylation as a new pathogenetic mechanism.
Human molecular genetics
Veneri FA,Prada V,Mastrangelo R,Ferri C,Nobbio L,Passalacqua M,Milanesi M,Bianchi F,Del Carro U,Vallat JM,Duong P,Svaren J,Schenone A,Grandis M,D'Antonio M
MA5-15256 was used in Western Blotting to indicate that the MPZD61N/+ mouse represents an authentic model of severe CMT1B affirming gain-of-glycosylation in P0 as a novel pathomechanism of disease.
Fri Dec 16 00:00:00 UTC 2022
Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue.
Current biology : CB
Moruzzi M,Nestor-Bergmann A,Goddard GK,Tarannum N,Brennan K,Woolner S
MA5-15256 was used in Immunohistochemistry to investigate how mechanical changes at the cellular level of an oncogenic cluster can translate into the generation of anisotropic strain across an epithelium, altering cell behavior in neighboring host tissue.
Mon Aug 09 00:00:00 UTC 2021
Adaptability of the ubiquitin-proteasome system to proteolytic and folding stressors.
The Journal of cell biology
Work JJ,Brandman O
MA5-15256 was used in Western Blotting to reveal the distinct effects of proteotoxic stressors and the versatility of cells in adapting the UPS.
Mon Mar 01 00:00:00 UTC 2021
Adaptability of the ubiquitin-proteasome system to proteolytic and folding stressors.
The Journal of cell biology
Work JJ,Brandman O
MA5-15256 was used in Western Blotting to reveal the distinct effects of proteotoxic stressors and the versatility of cells in adapting the UPS.
Mon Mar 01 00:00:00 UTC 2021
Delayed KCNQ1/KCNE1 assembly on the cell surface helps IKs fulfil its function as a repolarization reserve in the heart.
The Journal of physiology
Wilson ZT,Jiang M,Geng J,Kaur S,Workman SW,Hao J,Bernas T,Tseng GN
MA5-15256 was used in Immunoprecipitation to investigate how KCNQ1 and KCNE1 traffic in cells, where they associate to form IKs channels, and the distribution pattern of IKs channels relative to β-adrenergic signalling complex.
Thu Jul 01 00:00:00 UTC 2021
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
RNA biology
Grosse S,Lu YY,Coban I,Neumann B,Krebber H
MA5-15256 was used in Western Blot to show that Gbp2 and Hrb1 also function in nonsense mediated decay (NMD) of spliced premature termination codon (PTC)-containing mRNAs.
Fri Oct 01 00:00:00 UTC 2021
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
RNA biology
Grosse S,Lu YY,Coban I,Neumann B,Krebber H
MA5-15256 was used in Western Blot to show that Gbp2 and Hrb1 also function in nonsense mediated decay (NMD) of spliced premature termination codon (PTC)-containing mRNAs.
Fri Oct 01 00:00:00 UTC 2021
Effect of Different Nuclear Localization Signals on the Subcellular Localization and Anti-HIV-1 Function of the MxB Protein.
Frontiers in microbiology
Chai K,Wang Z,Pan Q,Tan J,Qiao W,Liang C
MA5-15256 was used in Western Blot to demonstrate that the bipartite nuclear localization signal has anti-HIV-1 activity when replacing the N-terminal sequence of the myxovirus resistance B gene.
Tue Jun 08 00:00:00 UTC 2021
Effect of Different Nuclear Localization Signals on the Subcellular Localization and Anti-HIV-1 Function of the MxB Protein.
Frontiers in microbiology
Chai K,Wang Z,Pan Q,Tan J,Qiao W,Liang C
MA5-15256 was used in Western Blot to demonstrate that the bipartite nuclear localization signal has anti-HIV-1 activity when replacing the N-terminal sequence of the myxovirus resistance B gene.
Tue Jun 08 00:00:00 UTC 2021
The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus.
Metabolic engineering communications
Kumar P,Sahoo DK,Sharma D
MA5-15256 was used in Western Blotting to identifying novel sets of promoters and terminators for increased recombinant protein expression in K. marxianus.
Tue Jun 01 00:00:00 UTC 2021
The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus.
Metabolic engineering communications
Kumar P,Sahoo DK,Sharma D
MA5-15256 was used in Western Blotting to identifying novel sets of promoters and terminators for increased recombinant protein expression in K. marxianus.
Tue Jun 01 00:00:00 UTC 2021
FRET-Based Detection and Quantification of HIV-1 Virion Maturation.
Frontiers in microbiology
Sarca AD,Sardo L,Fukuda H,Matsui H,Shirakawa K,Horikawa K,Takaori-Kondo A,Izumi T
MA5-15256 was used in Western Blotting to facilitate estimating the impact on the immune system of both extracellular intact and defective viruses by quantifying the Gag maturation status.
Sat Mar 27 00:00:00 UTC 2021
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
The Journal of biological chemistry
McKinzey DR,Gomathinayagam S,Griffin WC,Klinzing KN,Jeffries EP,Rajkovic A,Trakselis MA
MA5-15256 was used in Western Blot to identify and characterize two unique motifs within the primarily unstructured CTE that are required for localization of MCM8/9 to sites of mitomycin C (MMC)-induced DNA damage.
Tue Aug 24 00:00:00 UTC 2021
4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen.
eLife
Tabakh H,McFarland AP,Thomason MK,Pollock AJ,Glover RC,Zaver SA,Woodward JJ
MA5-15256 was used in Immunohistochemistry (Paraffin) to to demonstrate that 4-HNE is a previously unappreciated component of ROS-mediated toxicity encountered by bacteria within eukaryotic hosts.
Thu May 06 00:00:00 UTC 2021
4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen.
eLife
Tabakh H,McFarland AP,Thomason MK,Pollock AJ,Glover RC,Zaver SA,Woodward JJ
MA5-15256 was used in Immunohistochemistry (Paraffin) to to demonstrate that 4-HNE is a previously unappreciated component of ROS-mediated toxicity encountered by bacteria within eukaryotic hosts.
Thu May 06 00:00:00 UTC 2021
4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen.
eLife
Tabakh H,McFarland AP,Thomason MK,Pollock AJ,Glover RC,Zaver SA,Woodward JJ
MA5-15256 was used in Immunohistochemistry (Paraffin) to to demonstrate that 4-HNE is a previously unappreciated component of ROS-mediated toxicity encountered by bacteria within eukaryotic hosts.
Thu May 06 00:00:00 UTC 2021
The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
The Journal of biological chemistry
Harris LD,Le Pen J,Scholz N,Mieszczanek J,Vaughan N,Davis S,Berridge G,Kessler BM,Bienz M,Licchesi JDF
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Tue Aug 24 00:00:00 UTC 2021
Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
PloS one
Tong J,Tan L,Im YJ
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Wed Sep 22 00:00:00 UTC 2021
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Nature communications
Liu D,Song AT,Qi X,van Vliet PP,Xiao J,Xiong F,Andelfinger G,Nattel S
MA5-15256 was used in Western Blotting to reveal a critical non-canonical, cohesin-independent role for Shugoshin-1 in maintaining cardiac automaticity, offering a potential therapeutic avenue for cardiac pacemaking disorders.
Wed May 05 00:00:00 UTC 2021
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Nature communications
Liu D,Song AT,Qi X,van Vliet PP,Xiao J,Xiong F,Andelfinger G,Nattel S
MA5-15256 was used in Western Blotting to reveal a critical non-canonical, cohesin-independent role for Shugoshin-1 in maintaining cardiac automaticity, offering a potential therapeutic avenue for cardiac pacemaking disorders.
Wed May 05 00:00:00 UTC 2021
GhKWL1 Upregulates GhERF105 but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of Verticillium dahliae.
International journal of molecular sciences
Chen Y,Zhang M,Wang L,Yu X,Li X,Jin D,Zeng J,Ren H,Wang F,Song S,Yan X,Zhao J,Pei Y
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Thu Jul 08 00:00:00 UTC 2021
GhKWL1 Upregulates GhERF105 but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of Verticillium dahliae.
International journal of molecular sciences
Chen Y,Zhang M,Wang L,Yu X,Li X,Jin D,Zeng J,Ren H,Wang F,Song S,Yan X,Zhao J,Pei Y
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Thu Jul 08 00:00:00 UTC 2021
Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2.
Nature communications
Wu X,Zhang L,Li Y,Zhang W,Wang J,Cai C,Lin X
MA5-15256 was used in Immunocytochemistry to conduct gene therapy by injecting viral vectors using the canalostomy approach in Kcne1-/- mice to treat both the hearing and vestibular symptoms.
Fri Jan 29 00:00:00 UTC 2021
Gene therapy via canalostomy approach preserves auditory and vestibular functions in a mouse model of Jervell and Lange-Nielsen syndrome type 2.
Nature communications
Wu X,Zhang L,Li Y,Zhang W,Wang J,Cai C,Lin X
MA5-15256 was used in Immunocytochemistry to conduct gene therapy by injecting viral vectors using the canalostomy approach in Kcne1-/- mice to treat both the hearing and vestibular symptoms.
Fri Jan 29 00:00:00 UTC 2021
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation.
Life sciences
Pinho BR,Almeida LM,Duchen MR,Oliveira JMA
MA5-15256 was used in Immunoprecipitation to show that the strategy of allosteric Hsp70 activation holds potential for HD.
Mon Nov 15 00:00:00 UTC 2021
Sensing soluble uric acid by Naip1-Nlrp3 platform.
Cell death & disease
Braga TT,Davanso MR,Mendes D,de Souza TA,de Brito AF,Cruz MC,Hiyane MI,de Lima DS,Nunes V,de Fátima Giarola J,Souto DEP,Próchnicki T,Lauterbach M,Biscaia SMP,de Freitas RA,Curi R,Pontillo A,Latz E,Camara NOS
MA5-15256 was used in Western Blot to find that murine Naip1 expression in human macrophages induces IL-1β expression, fatty acid production and an inflammation-related response upon sUA stimulation, a process reversed by the pharmacological and genetic inhibition of Nlrp3.
Fri Feb 05 00:00:00 UTC 2021
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
ACS chemical biology
Helton LG,Soliman A,von Zweydorf F,Kentros M,Manschwetus JT,Hall S,Gilsbach B,Ho FY,Athanasopoulos PS,Singh RK,LeClair TJ,Versées W,Raimondi F,Herberg FW,Gloeckner CJ,Rideout H,Kortholt A,Kennedy EJ
MA5-15256 was used in Western Blotting to show that inhibited dimerization decreases kinase activity and inhibits ROS production and PD-linked apoptosis in primary cortical neurons.
Fri Nov 19 00:00:00 UTC 2021
PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.
Scientific reports
Nyamsuren G,Rapp G,Dihazi H,Zeisberg EM,Tampe D,Tampe B,Zeisberg M
MA5-15256 was used in Western Blotting to provide additional evidence for the anti-fibrotic activity of ARNT-ARNT homodimers and reveal Ser77 phosphorylation as a novel pharmacological target to realize the therapeutic potential of increased ARNT transactivation activity.
Wed Dec 15 00:00:00 UTC 2021
Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin.
STAR protocols
Kim H,Jiang P
MA5-15256 was used in Immunohistochemistry to demonstrate a step-by-step protocol for generating fused forebrain organoids derived from human pluripotent stem cells.
Fri Jun 18 00:00:00 UTC 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
MA5-15256 was used in Immunohistochemistry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 UTC 2020
FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Journal of the American Society of Nephrology : JASN
Subramanian B,Chun J,Perez-Gill C,Yan P,Stillman IE,Higgs HN,Alper SL,Schlöndorff JS,Pollak MR
MA5-15256 was used in Immunoprecipitation to examine INF2 isoforms present in podocytes and evaluated INF2 cleavage as an explanation for immunoblot findings.
Sat Feb 01 00:00:00 UTC 2020
Increased AMP deaminase activity decreases ATP content and slows protein degradation in cultured skeletal muscle.
Metabolism: clinical and experimental
Davis PR,Miller SG,Verhoeven NA,Morgan JS,Tulis DA,Witczak CA,Brault JJ
MA5-15256 was used in Western Blot to determine whether the concentration of the adenine nucleotide pool (ATP + ADP + AMP) affects protein degradation in muscle cells.
Wed Jul 01 00:00:00 UTC 2020
Chlamydia-induced curvature of the host-cell plasma membrane is required for infection.
Proceedings of the National Academy of Sciences of the United States of America
Hänsch S,Spona D,Murra G,Köhrer K,Subtil A,Furtado AR,Lichtenthaler SF,Dislich B,Mölleken K,Hegemann JH
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunocytochemistry
Tue Feb 04 00:00:00 UTC 2020
Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS.
PLoS pathogens
Webb LG,Veloz J,Pintado-Silva J,Zhu T,Rangel MV,Mutetwa T,Zhang L,Bernal-Rubio D,Figueroa D,Carrau L,Fenutria R,Potla U,Reid SP,Yount JS,Stapleford KA,Aguirre S,Fernandez-Sesma A
MA5-15256 was used in Western Blotting to show Chikungunya virus interacts with and antagonizes cGAS-STING signaling.
Thu Oct 01 00:00:00 UTC 2020
Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast.
Journal of cell science
Mathew V,Kumar A,Jiang YK,West K,Tam AS,Stirling PC
MA5-15256 was used in Immunoprecipitation to demonstrate the role of Cdc48 in the regulation or stabilization of splicing subcomplexes.
Thu Dec 03 00:00:00 UTC 2020
The Yeast Hsp70 Cochaperone Ydj1 Regulates Functional Distinction of Ssa Hsp70s in the Hsp90 Chaperoning Pathway.
Genetics
Gaur D,Singh P,Guleria J,Gupta A,Kaur S,Sharma D
MA5-15256 was used in Western Blotting to reveal a novel role of Ydj1 in determining the functional distinction among Hsp70 isoforms with respect to the Hsp90 chaperoning action.
Wed Jul 01 00:00:00 UTC 2020
The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing.
Bioscience reports
Wakula M,Balcerak A,Rubel T,Chmielarczyk M,Konopinski R,Lyczek F,Grzybowska EA
MA5-15256 was used in Western Blotting to present the results of the two different approaches to obtain more comprehensive information concerning HAX1 interactome data.
Fri Nov 27 00:00:00 UTC 2020
Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear.
Hearing research
Tarang S,Pyakurel U,Weston MD,Vijayakumar S,Jones T,Wagner KU,Rocha-Sanchez SM
MA5-15256 was used in Immunohistochemistry-immunofluorescence to characterize a Cre-activated, Doxycycline (Dox)-controlled, conditional CycD1 overexpression model, which when bred to a tetracycline-controlled transcriptional activator and the Atoh1-cre mouse lines, allow for transient CycD1 overexpression and pRBs' downregulation in the inner ear in a reversible fashion.
Fri May 01 00:00:00 UTC 2020
Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae.
PloS one
Sitron CS,Park JH,Giafaglione JM,Brandman O
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Fri Apr 17 00:00:00 UTC 2020
Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.
Scientific reports
Rodríguez-González C,Lin S,Arkan S,Hansen C
MA5-15256 was used in Western Blotting to investigate the effect of knock out (KO) of three individual DNAJ genes in HEK293 cells expressing polyglutamine74exon1 huntingtin (polyQ74htt).
Mon May 18 00:00:00 UTC 2020
Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.
Scientific reports
Rodríguez-González C,Lin S,Arkan S,Hansen C
MA5-15256 was used in Western Blotting to investigate the effect of knock out (KO) of three individual DNAJ genes in HEK293 cells expressing polyglutamine74exon1 huntingtin (polyQ74htt).
Mon May 18 00:00:00 UTC 2020
Deciphering the role of UBA-like domains in intraflagellar distribution and functions of myosin XXI in Leishmania.
PloS one
Bajaj R,Ambaru B,Gupta CM
MA5-15256 was used in Western Blotting to show that the presence of UBLDs in Myo21 are essentially required for its predominant localization to the flagellum base.
Mon Jul 20 00:00:00 UTC 2020
Deciphering the role of UBA-like domains in intraflagellar distribution and functions of myosin XXI in Leishmania.
PloS one
Bajaj R,Ambaru B,Gupta CM
MA5-15256 was used in Western Blotting to show that the presence of UBLDs in Myo21 are essentially required for its predominant localization to the flagellum base.
Mon Jul 20 00:00:00 UTC 2020
Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.
Nature communications
Liu Z,Li N,Zhang Y,Li Y
MA5-15256 was used in Western Blotting to reveal a genetic and molecular mechanism by which the transcription factors MYC3/4 recruit KIX8/9 and PPD1/2 to the promoter of GIF1 and repress its expression, thereby determining seed size in Arabidopsis.
Wed Apr 15 00:00:00 UTC 2020
Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.
Nature communications
Liu Z,Li N,Zhang Y,Li Y
MA5-15256 was used in Western Blotting to reveal a genetic and molecular mechanism by which the transcription factors MYC3/4 recruit KIX8/9 and PPD1/2 to the promoter of GIF1 and repress its expression, thereby determining seed size in Arabidopsis.
Wed Apr 15 00:00:00 UTC 2020
Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.
Nature communications
Liu Z,Li N,Zhang Y,Li Y
MA5-15256 was used in Western Blotting to reveal a genetic and molecular mechanism by which the transcription factors MYC3/4 recruit KIX8/9 and PPD1/2 to the promoter of GIF1 and repress its expression, thereby determining seed size in Arabidopsis.
Wed Apr 15 00:00:00 UTC 2020
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Nature communications
Choi I,Zhang Y,Seegobin SP,Pruvost M,Wang Q,Purtell K,Zhang B,Yue Z
MA5-15256 was used in Western Blot to identify a neuroprotective function of microglia in the clearance of α-synuclein via TLR4-NF-κB-p62 mediated synucleinphagy.
Fri Mar 13 00:00:00 UTC 2020
Efficient Strategies for Microglia Replacement in the Central Nervous System.
Cell reports
Xu Z,Rao Y,Huang Y,Zhou T,Feng R,Xiong S,Yuan TF,Qin S,Lu Y,Zhou X,Li X,Qin B,Mao Y,Peng B
MA5-15256 was used in Immunohistochemistry to develop three efficient strategies for microglia replacement: microglia replacement by bone marrow transplantation (mrBMT), microglia replacement by peripheral blood (mrPB), and microglia replacement by microglia transplantation (mrMT).
Tue Aug 11 00:00:00 UTC 2020
Rpa1 mediates an immune response to avrRpm1Psa and confers resistance against Pseudomonas syringae pv. actinidiae.
The Plant journal : for cell and molecular biology
Yoon M,Rikkerink EHA
MA5-15256 was used in Immunoprecipitation to investigate the AvrRpm1-triggered immune responses in Nicotiana species and isolated Rpa1 via a reverse genetic screen in Nicotiana tabacum.
Fri May 01 00:00:00 UTC 2020
Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture.
Scientific reports
Yeliseev A,van den Berg A,Zoubak L,Hines K,Stepnowski S,Williston K,Yan W,Gawrisch K,Zmuda J
MA5-15256 was used in Western Blotting to demonstrate that the mammalian Expi293F amino acid labelling kit is suitable for preparation of multi-milligram quantities of high quality, selectively stable isotope-labeled GPCR for studies by nuclear magnetic resonance.
Thu Oct 08 00:00:00 UTC 2020
Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin.
The Journal of biological chemistry
Mohan HM,Yang B,Dean NA,Raghavan M
MA5-15256 was used in Immunoprecipitation to show that calreticulin (CRT), an endoplasmic reticulum (ER) glycoprotein chaperone, promotes the secretory trafficking of ATZ, enhancing the media:cell ratio.
Fri Dec 04 00:00:00 UTC 2020
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis.
Circulation
Aravani D,Morris GE,Jones PD,Tattersall HK,Karamanavi E,Kaiser MA,Kostogrys RB,Ghaderi Najafabadi M,Andrews SL,Nath M,Ye S,Stringer EJ,Samani NJ,Webb TR
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Tue Aug 06 00:00:00 UTC 2019
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis.
Circulation
Aravani D,Morris GE,Jones PD,Tattersall HK,Karamanavi E,Kaiser MA,Kostogrys RB,Ghaderi Najafabadi M,Andrews SL,Nath M,Ye S,Stringer EJ,Samani NJ,Webb TR
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Tue Aug 06 00:00:00 UTC 2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
MA5-15256 was used in Immunocytochemistry-immunoflourescence to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 UTC 2019
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
The Journal of cell biology
Awadia S,Huq F,Arnold TR,Goicoechea SM,Sun YJ,Hou T,Kreider-Letterman G,Massimi P,Banks L,Fuentes EJ,Miller AL,Garcia-Mata R
MA5-15256 was used in Western Blotting to show that SGEF forms a ternary complex with Scribble and Dlg1, two members of the Scribble complex.
Mon Aug 05 00:00:00 UTC 2019
DEAD-box RNA helicase Belle posttranscriptionally promotes gene expression in an ATPase activity-dependent manner.
RNA (New York, N.Y.)
Liao SE,Kandasamy SK,Zhu L,Fukunaga R
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Mon Jul 01 00:00:00 UTC 2019
Human myosin 1e tail but not motor domain replaces fission yeast Myo1 domains to support myosin-I function during endocytosis.
Experimental cell research
Barger SR,James ML,Pellenz CD,Krendel M,Sirotkin V
MA5-15256 was used in Western Blotting to provides insight into the role of individual myosin-I domains, expand the utility of fission yeast as a simple model system to study the effects of disease-associated MYO1E mutations, and support a model of co-evolution between a myosin motor and its actin track.
Fri Nov 15 00:00:00 UTC 2019
Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells.
Cell reports
Hwang S,Williams JF,Kneissig M,Lioudyno M,Rivera I,Helguera P,Busciglio J,Storchova Z,King MC,Torres EM
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Tue Nov 19 00:00:00 UTC 2019
Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity.
eLife
Ruiz M,Bodhicharla R,Ståhlman M,Svensk E,Busayavalasa K,Palmgren H,Ruhanen H,Boren J,Pilon M
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Tue Nov 26 00:00:00 UTC 2019
IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP.
eLife
Roy A,Ghosh A,Kumar B,Chandran B
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Mon Nov 04 00:00:00 UTC 2019
Polar localization of the ATPase ClpV-5 occurs independent of type VI secretion system apparatus proteins in Burkholderia thailandensis.
BMC research notes
Lennings J,Mayer C,Makhlouf M,Brötz-Oesterhelt H,Schwarz S
MA5-15256 was used in Western Blotting to investigate if the type VI secretion system apparatus confers polar localisation of ClpV-5.
Thu Feb 28 00:00:00 UTC 2019
Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic Localization, Decreases Its Phosphorylation, and Increases Detyrosination of Tubulin.
International journal of molecular sciences
Cao Y,Banks DA,Mattei AM,Riddick AT,Reed KM,Zhang AM,Pickering ES,Hinton SD
MA5-15256 was used in Western Blotting to study the role of MK-STYX on histone deacetylase isofrom 6 dynamics.
Fri Mar 22 00:00:00 UTC 2019
ARID1A promotes genomic stability through protecting telomere cohesion.
Nature communications
Zhao B,Lin J,Rong L,Wu S,Deng Z,Fatkhutdinov N,Zundell J,Fukumoto T,Liu Q,Kossenkov A,Jean S,Cadungog MG,Borowsky ME,Drapkin R,Lieberman PM,Abate-Shen CT,Zhang R
MA5-15256 was used in Western Blotting to show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis.
Fri Sep 06 00:00:00 UTC 2019
Proof of principle: Physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep.
PloS one
Yu K,Rodriguez MD,Paul Z,Gordon E,Rice K,Triplett EW,Keller-Wood M,Wood CE
MA5-15256 was used in Immunohistochemistry to present evidence for the transfer of bacteria from the maternal bloodstream of late-gestation pregnant sheep into the foetus.
Mon Feb 03 00:00:00 UTC 2020
An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration.
Cell reports
Flores BN,Li X,Malik AM,Martinez J,Beg AA,Barmada SJ
MA5-15256 was used in Western Blotting to study the relationship between the RNA binding properties of TDP43 and neurodegeneration.
Tue Apr 23 00:00:00 UTC 2019
Mycobacterium tuberculosis LprE Suppresses TLR2-Dependent Cathelicidin and Autophagy Expression to Enhance Bacterial Survival in Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Padhi A,Pattnaik K,Biswas M,Jagadeb M,Behera A,Sonawane A
MA5-15256 was used in Immunocytochemistry to indicate that LprE Mtb is an important virulence factor that plays a crucial role in mycobacterial pathogenesis in the context of innate immunity.
Fri Nov 15 00:00:00 UTC 2019
Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee.
Frontiers in physiology
Zhang V,Kucharski R,Landers C,Richards SN,Bröer S,Martin RE,Maleszka R
MA5-15256 was used in Western Blotting to suggest that multiple cellular mechanisms, including gene splicing and epigenomic communication systems, may be adopted to increase the potential of a conserved gene to contribute to lineage-specific behavioral outcomes.
Sat Nov 04 00:00:00 UTC 2023
ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis.
Nature communications
Yang JS,Hsu JW,Park SY,Lee SY,Li J,Bai M,Alves C,Tseng W,Michelet X,Ho IC,Hsu VW
MA5-15256 was used in Western Blotting to advance the understanding of intracellular transport by revealing how the coordination of multiple pathways can be achieved and demonstrate the role of NADH in cellular energetics.
Fri Sep 06 00:00:00 UTC 2019
StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Nature methods
Jacobs CL,Badiee RK,Lin MZ
MA5-15256 was used in Western Blotting to describe a generalizable design for drug-inducible proteins in which proteins are rescued from StaPL-induced fragmentation by HCV NS3 protease inhibitors.
Sun Jul 01 00:00:00 UTC 2018
Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
Developmental cell
Kale A,Ji Z,Kiparaki M,Blanco J,Rimesso G,Flibotte S,Baker NE
MA5-15256 was used in Immunohistochemistry to study the function of ribosomal Protein S12e in cell competition.
Mon Jan 08 00:00:00 UTC 2018
A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism.
Autophagy
Sun X,Yang Y,Zhong XZ,Cao Q,Zhu XH,Zhu X,Dong XP
MA5-15256 was used in Immunoprecipitation to suggest that lysosomal Ca2+ signaling is an essential component of the canonical MTORC1-dependent autophagy pathway and MCOLN1 provides a negative feedback regulation of MTORC1 to prevent excessive loss of MTORC1 function during starvation.
Tue Feb 26 00:00:00 UTC 2019
Identification of the Functional Autophagy-Regulatory Domain in HCLS1-Associated Protein X-1 That Resists Against Oxidative Stress.
DNA and cell biology
Li YL,Cai WF,Wang L,Liu GS,Paul C,Jiang L,Wang B,Gao X,Wang Y,Wu SZ
MA5-15256 was used in Western Blotting to investigate whether autophagy can be upregulated in response to HCLS1 Associated Protein X-1(HAX1) overexpression and identify the functional motif in HAX1 responsible for the autophagic induction.
Tue May 01 00:00:00 UTC 2018
Effect of zinc intake on hepatic autophagy during acute alcohol intoxication.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Liuzzi JP,Narayanan V,Doan H,Yoo C
MA5-15256 was used in Western Blotting to study the effect of zinc on hepatic autophagy during acute alcohol intoxication.
Sun Apr 01 00:00:00 UTC 2018
Tuning of delta-protocadherin adhesion through combinatorial diversity.
eLife
Bisogni AJ,Ghazanfar S,Williams EO,Marsh HM,Yang JY,Lin DM
MA5-15256 was used in Western Blotting to study how intra- and interfamily delta-protocadherin interactions can greatly amplify the impact of this small subfamily on neuronal function.
Fri Dec 14 00:00:00 UTC 2018
Tuning of delta-protocadherin adhesion through combinatorial diversity.
eLife
Bisogni AJ,Ghazanfar S,Williams EO,Marsh HM,Yang JY,Lin DM
MA5-15256 was used in Western Blotting to study how intra- and interfamily delta-protocadherin interactions can greatly amplify the impact of this small subfamily on neuronal function.
Fri Dec 14 00:00:00 UTC 2018
The yeast stress inducible Ssa Hsp70 reduces α-synuclein toxicity by promoting its degradation through autophagy.
PLoS genetics
Gupta A,Puri A,Singh P,Sonam S,Pandey R,Sharma D
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes.
Nature communications
Zhu L,Kandasamy SK,Liao SE,Fukunaga R
MA5-15256 was used in Western Blotting to identify meisosis regulator and mRNA stability factor 1 as a regulator of oocyte maturation through post-transcriptional gene regulation.
Tue Oct 02 00:00:00 UTC 2018
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.
Frontiers in microbiology
Raze D,Verwaerde C,Deloison G,Werkmeister E,Coupin B,Loyens M,Brodin P,Rouanet C,Locht C
MA5-15256 was used in Immunocytochemistry-immunoflourescence to examine the localisation of heparin-binding hemagglutinin adhesin (HBHA) in Mycobacterium tuberculosis, and reveal a role HBHA in the formation of intracytosolic lipid inclusions.
Tue Sep 29 00:00:00 UTC 2020
Cowpea chlorotic mottle bromovirus replication proteins support template-selective RNA replication in Saccharomyces cerevisiae.
PloS one
Sibert BS,Navine AK,Pennington J,Wang X,Ahlquist P
MA5-15256 was used in Western Blotting to study the ability of CCMV to support spherule formation and RNA replication in yeast.
Mon May 20 00:00:00 UTC 2019
Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.
Molecular cell
Yeom J,Wayne KJ,Groisman EA
MA515256 was used in western blot to report that MgtC protects PhoP from degradation by outcompeting ClpS for binding to PhoP
Thu Apr 20 00:00:00 UTC 2017
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Developmental cell
Wang Z,Zhang F,He J,Wu P,Tay LWR,Cai M,Nian W,Weng Y,Qin L,Chang JT,McIntire LB,Di Paolo G,Xu J,Peng J,Du G
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Mon Oct 23 00:00:00 UTC 2017
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Developmental cell
Wang Z,Zhang F,He J,Wu P,Tay LWR,Cai M,Nian W,Weng Y,Qin L,Chang JT,McIntire LB,Di Paolo G,Xu J,Peng J,Du G
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Immunoprecipitation
Mon Oct 23 00:00:00 UTC 2017
SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.
The Plant cell
Ahn G,Kim H,Kim DH,Hanh H,Yoon Y,Singaram I,Wijesinghe KJ,Johnson KA,Zhuang X,Liang Z,Stahelin RV,Jiang L,Cho W,Kang BH,Hwang I
MA5-15256 was used in Western Blotting to report the essential role of SH3 Domain-Containing Protein 2 (SH3P2) in the tubulation of membrane structures during cell plate formation in Arabidopsis thaliana.
Thu Jun 01 00:00:00 UTC 2017
SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.
The Plant cell
Ahn G,Kim H,Kim DH,Hanh H,Yoon Y,Singaram I,Wijesinghe KJ,Johnson KA,Zhuang X,Liang Z,Stahelin RV,Jiang L,Cho W,Kang BH,Hwang I
MA5-15256 was used in Western Blotting to report the essential role of SH3 Domain-Containing Protein 2 (SH3P2) in the tubulation of membrane structures during cell plate formation in Arabidopsis thaliana.
Thu Jun 01 00:00:00 UTC 2017
Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus.
eLife
Zhong Y,Wang J,Henderson MJ,Yang P,Hagen BM,Siddique T,Vogel BE,Deng HX,Fang S
Published figure using GFP Tag monoclonal antibody (Product # MA5-15256) in Western Blot
Tue May 02 00:00:00 UTC 2017
An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways.
PLoS genetics
Kamber Kaya HE,Ditzel M,Meier P,Bergmann A
MA515256 was used in immunoprecipitation and western blot to study the role of non-degradative ubiquitylation of the Drosophila initiator caspase Dronc in vivo
Wed Feb 01 00:00:00 UTC 2017
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways.
Nature communications
Chaudhari SN,Kipreos ET
MA5-15256 was used in Western Blotting to describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan.
Thu Aug 03 00:00:00 UTC 2017
Sortilin limits EGFR signaling by promoting its internalization in lung cancer.
Nature communications
Al-Akhrass H,Naves T,Vincent F,Magnaudeix A,Durand K,Bertin F,Melloni B,Jauberteau MO,Lalloué F
MA5-15256 was used in Western Blotting to identify sortilin as a key regulator of epidermal growth factor receptor internalisation.
Mon Oct 30 00:00:00 UTC 2017
Sortilin limits EGFR signaling by promoting its internalization in lung cancer.
Nature communications
Al-Akhrass H,Naves T,Vincent F,Magnaudeix A,Durand K,Bertin F,Melloni B,Jauberteau MO,Lalloué F
MA5-15256 was used in Western Blotting to identify sortilin as a key regulator of epidermal growth factor receptor internalisation.
Mon Oct 30 00:00:00 UTC 2017
A single point mutation in a TssB/VipA homolog disrupts sheath formation in the type VI secretion system of Proteus mirabilis.
PloS one
Saak CC,Zepeda-Rivera MA,Gibbs KA
MA5-15256 was used in Western Blotting to propose that this mutation could be utilized as an important tool for studying functions and behaviors associated with T6S systems.
Tue Oct 31 00:00:00 UTC 2017
HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.
Cell communication and signaling : CCS
Shen X,Jia Z,D'Alonzo D,Wang X,Bruder E,Emch FH,De Geyter C,Zhang H
MA5-15256 was used in Immunoprecipitation to study the underlying molecular pathways involved in the dynamics of adhesive structures that interact with the extracellular matrix.
Thu Jan 05 00:00:00 UTC 2017
A Puccinia striiformis f. sp. tritici secreted protein activates plant immunity at the cell surface.
Scientific reports
Dagvadorj B,Ozketen AC,Andac A,Duggan C,Bozkurt TO,Akkaya MS
MA5-15256 was used in Western Blotting to report a small cysteine-rich protein, PstSCR1, from Puccinia striiformis f. sp. tritici that activates immunity in a model plant.
Tue Apr 25 00:00:00 UTC 2017
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
Scientific reports
Aprile FA,Källstig E,Limorenko G,Vendruscolo M,Ron D,Hansen C
MA5-15256 was used in Western Blotting to demonstrate that a CRISPR/Cas9-mediated knockout of DNAJB6, in HEK293T cells expressing α-syn, causes a massive increase in α-syn aggregation.
Tue Aug 22 00:00:00 UTC 2017
Suppressor of fused (Sufu) promotes epithelial-mesenchymal transition (EMT) in cervical squamous cell carcinoma.
Oncotarget
Zhang Z,Zou Y,Liang M,Chen Y,Luo Y,Yang B,Liu F,Qin Y,He D,Wang F,Huang O
MA5-15256 was used in Immunoprecipitation to highlight a novel role for Sufu in cervical carcinogenesis.
Tue Dec 26 00:00:00 UTC 2017
The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
The Journal of cell biology
Balachandran RS,Heighington CS,Starostina NG,Anderson JW,Owen DL,Vasudevan S,Kipreos ET
MA5-15256 was used in immunocytochemistry to study degradation of cyclin B1
Mon Oct 24 00:00:00 UTC 2016
The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
The Journal of cell biology
Balachandran RS,Heighington CS,Starostina NG,Anderson JW,Owen DL,Vasudevan S,Kipreos ET
MA5-15256 was used in immunocytochemistry to study degradation of cyclin B1
Mon Oct 24 00:00:00 UTC 2016
Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang H,Sun S,Wu L,Pchitskaya E,Zakharova O,Fon Tacer K,Bezprozvanny I
MA5-15256 was used in immunocytochemistry to study the role of the STIM2-regulated TRPC6/Orai2 nSOC channel complex in dendritic mushroom spines in models of Alzheimer's disease
Wed Nov 23 00:00:00 UTC 2016
α-Integrin expression and function modulates presentation of cell surface calreticulin.
Cell death & disease
Liu CC,Leclair P,Monajemi M,Sly LM,Reid GS,Lim CJ
MA5-15256 was used in flow cytometry to determine modulation of presentation of cell surfaced calreticulin by alpha-integrin function and expression
Thu Jun 16 00:00:00 UTC 2016
Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells.
Journal of neuroscience research
Lin PY,Folorunso O,Taglialatela G,Pierce A
MA5-15256 was used in Western Blotting to show that HSF1 overexpression protects against TDP-43 pathology by upregulation of chaperones, especially HSP70, rather than enhancing autophagy or the UPS during times of proteotoxic stress.
Fri Jul 01 00:00:00 UTC 2016
Anion channelrhodopsins for inhibitory cardiac optogenetics.
Scientific reports
Govorunova EG,Cunha SR,Sineshchekov OA,Spudich JL
MA5-15256 was used in immunocytochemistry to examine the use of anion channelrhodopsins to control heart muscles
Thu Sep 15 00:00:00 UTC 2016
Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.
Science (New York, N.Y.)
Shen PS,Park J,Qin Y,Li X,Parsawar K,Larson MH,Cox J,Cheng Y,Lambowitz AM,Weissman JS,Brandman O,Frost A
Published figure using GFP monoclonal antibody (Product # MA5-15256) in Western Blot
Fri Jan 02 00:00:00 UTC 2015
Tunable and reversible drug control of protein production via a self-excising degron.
Nature chemical biology
Chung HK,Jacobs CL,Huo Y,Yang J,Krumm SA,Plemper RK,Tsien RY,Lin MZ
MA5-15256 was used in western blot to establish a method to directly control specific protein production in response to chemicals
Tue Sep 01 00:00:00 UTC 2015
Tunable and reversible drug control of protein production via a self-excising degron.
Nature chemical biology
Chung HK,Jacobs CL,Huo Y,Yang J,Krumm SA,Plemper RK,Tsien RY,Lin MZ
MA5-15256 was used in western blot to establish a method to directly control specific protein production in response to chemicals
Tue Sep 01 00:00:00 UTC 2015
Two-tiered histidine kinase pathway involved in heat shock and salt sensing in the general stress response of Sphingomonas melonis Fr1.
Journal of bacteriology
Kaczmarczyk A,Hochstrasser R,Vorholt JA,Francez-Charlot A
MA5-15256 was used in western blot to demonstrate that a two-tiered histidine kinase pathway regulates the general stress response in Sphingomonas melonis
Wed Apr 01 00:00:00 UTC 2015
REGULATOR OF BULB BIOGENESIS1 (RBB1) Is Involved in Vacuole Bulb Formation in Arabidopsis.
PloS one
Han SW,Alonso JM,Rojas-Pierce M
MA5-15256 was used in western blot to isolate mutants with abnormal trafficking to the vacuole or aberrant vacuole morphology
Wed Apr 27 00:00:00 UTC 2016
Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury.
Stem cell research & therapy
Kim Y,Jo SH,Kim WH,Kweon OK
MA5-15256 was used in western blot to characterize dogs with acute spinal cord injury and intravenously injected adipose derived mesenchymal stem cells for antioxidant and anti-inflammatory effects
Thu Nov 26 00:00:00 UTC 2015
Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1.
The Journal of biological chemistry
Diamond MI,Cai S,Boudreau A,Carey CJ,Lyle N,Pappu RV,Swamidass SJ,Bissell M,Piwnica-Worms H,Shao J
MA515256 was used in immunoprecipitation to elucidate the antitumor mechanism of Pfn1
Fri Apr 03 00:00:00 UTC 2015
SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain.
Biochimica et biophysica acta
Hong X,Avetisyan M,Ronilo M,Standley S
MA5-15256 was used in immunocytochemistry to explore how the different domains of SAP97 regulate its localization.
Sun Feb 01 00:00:00 UTC 2015
Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila.
Genetics
Stronach B,Lennox AL,Garlena RA
MA5-15256 was used in western blot to study the role of MAP3K proteins in JNK signaling in Drosophila
Sun Jun 01 00:00:00 UTC 2014
Comparative functional analysis of full-length and N-terminal fragments of phytochrome C, D and E in red light-induced signaling.
The New phytologist
Ádám É,Kircher S,Liu P,Mérai Z,González-Schain N,Hörner M,Viczián A,Monte E,Sharrock RA,Schäfer E,Nagy F
MA5-15256 was used in western blot to perform functional analysis of phytochrome C, D and E
Tue Oct 01 00:00:00 UTC 2013
An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein.
Drug testing and analysis
Costa B,Grillone AF,Salvetti A,Rocchiccioli S,Iacopetti P,Daniele S,Da Pozzo E,Campiglia P,Novellino E,Martini C,Rossi L
MA5-15256 was used in ELISA to develop a rapid and cheap method for high-throughput screening of putative inhibitors of MDM2-p53 complex formation
Mon Jul 01 00:00:00 UTC 2013
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
The Journal of biological chemistry
Thapa N,Choi S,Hedman A,Tan X,Anderson RA
MA5-15256 was used in immunocytochemistry to study how tumor cells sustain oncogenic signals in the absence of cell matrix interactions
Fri Nov 29 00:00:00 UTC 2013
Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses.
Virology
Chauhan VS,Furr SR,Sterka DG,Nelson DA,Moerdyk-Schauwecker M,Marriott I,Grdzelishvili VZ
MA5-15256 was used in western blot to investigate the effect of vesicular stomatitis virus infection on CNS system and inflammation induction
Mon May 10 00:00:00 UTC 2010
Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells: necessity of immunosuppressive treatment for sustained improvement.
Neurological research
Toriumi H,Yoshikawa M,Matsuda R,Nishimura F,Yamada S,Hirabayashi H,Nakase H,Nonaka J,Ouji Y,Ishizaka S,Sakaki T
MA5-15256 was used in immunohistochemistry to examine the therapeutic efficacy of allogenic ES cells in a Parkinson's disease model
Wed Apr 01 00:00:00 UTC 2009
Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor.
The Journal of biological chemistry
Wang R,Chen W,Cai S,Zhang J,Bolstad J,Wagenknecht T,Liu Z,Chen SR
MA5-15256 was used in western blot to localize the NH(2)-terminal mutation hotspot in the cardiac ryanodine receptor
Fri Jun 15 00:00:00 UTC 2007
Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump.
The Journal of biological chemistry
Bossuyt J,Despa S,Martin JL,Bers DM
MA5-15256 was used in western blot to investigate FRET between phospholemman and the Na/K-ATPase pump
Fri Oct 27 00:00:00 UTC 2006
Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand.
The Journal of biological chemistry
Feige JN,Gelman L,Tudor C,Engelborghs Y,Wahli W,Desvergne B
MA5-15256 was used in western blot to study the behaviour of peroxisome proliferator-activated receptors
Fri May 06 00:00:00 UTC 2005
Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy.
Cell cycle (Georgetown, Tex.)
Newcomb EW,Tamasdan C,Entzminger Y,Arena E,Schnee T,Kim M,Crisan D,Lukyanov Y,Miller DC,Zagzag D
MA5-15256 was used in immunohistochemistry to evaluate flavopiridol for anti-glioma activity in vivo
Sun Feb 01 00:00:00 UTC 2004
Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites.
The Journal of biological chemistry
Zhang J,Liu Z,Masumiya H,Wang R,Jiang D,Li F,Wagenknecht T,Chen SR
MA5-15256 was used in western blot to gain insights into the structural basis of DR3 function in ryanodine receptors
Fri Apr 18 00:00:00 UTC 2003
Aspergillus nidulans catalase-peroxidase gene (cpeA) is transcriptionally induced during sexual development through the transcription factor StuA.
Eukaryotic cell
Scherer M,Wei H,Liese R,Fischer R
MA5-15256 was used in western blot to characterize the catalase-peroxidase enzyme in Aspergillus nidulans
Tue Oct 01 00:00:00 UTC 2002
Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.
The Journal of biological chemistry
Jackson M,Baird JW,Cambray N,Ansell JD,Forrester LM,Graham GJ
MA5-15256 was used in western blot to clone and characterize Ehox
Fri Oct 11 00:00:00 UTC 2002
