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Product Details
PA1-85519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified native human growth hormone.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2111141
Product Specific Information
Sheep anti Human growth hormone antibody recognizes human growth hormone. Growth hormone is a small peptide hormone released by the anterior pituitary under the control of the hypothalamus. It acts to control body growth and metabolic activity.
Target Information
Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GH; Growth hormone; Growth hormone 1; growth hormone B5; HGH; Pituitary growth hormone; Somatotropin
Gene Aliases: GH; GH-N; GH1; GHB5; GHN; hGH-N; IGHD1B
UniProt ID: (Human) P01241
Entrez Gene ID: (Human) 2688
positive regulation of receptor internalization
JAK-STAT cascade
positive regulation of activation of JAK2 kinase activity
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
response to estradiol
positive regulation of multicellular organism growth
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of MAP kinase activity
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
bone maturation
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