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Proteintech
IGSF2 Monoclonal Antibody (1E6A7)
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Product Details
66333-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E6A7
Immunogen
IGSF2 Fusion Protein Ag23297 (260-603 aa encoded by BC136484)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ETWMFITKK QTDQTTLRIQ PAVKDFQVNI TADSLFAEGK PLELVCLVVS SGRDPQLQGI WFFNGTEIAH IDAGGVLGLK NDYKERASQG ELQVSKLGPK AFSLKIFSLG PEDEGAYRCV VAEVMKTRTG SWQVLQRKQS PDSHVHLRKP AARSVVVSTK NKQQVVWEGE TLAFLCKAGG AESPLSVSWW HIPRDQTQPE FVAGMGQDGI VQLGASYGVP SYHGNTRLEK MDWATFQLEI TFTAITDSGT YECRVSEKSR NQARDLSWTQ KISVTVKSLE SSLQVSLMSR QPQVMLTNTF DLSCVVRAGY SDLKVPLTVT WQFQPASSHI FHQLIRITHN GTIEW (260-603 aa encoded by BC136484)
Target Information
CD101, also known as the V7 antigen, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is characterized by 7 Ig-like IgV domains and a short cytoplasmic tail with several phosphorylation sites. CD101 forms a disulfide-linked homodimer, although its precise function remains unknown. Expression of CD101 is observed on monocytes, granulocytes, dendritic cells, Langerhans cells, and activated T cells. It is also found on a subset of CD25+Foxp3+ regulatory T cells, which exhibit higher suppressive properties in vitro and in vivo. CD101 plays a role in modulating immune responses. Cross-linking CD101 can antagonize TCR/CD3-mediated lymphocyte activation, while CD101+ CD28+ T cells are highly responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can enhance proliferation, suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. In mice, CD101 is expressed on a subpopulation of regulatory T cells (CD4+, CD25+, Foxp3+) with high suppressor activity. In humans, CD101 expression on peripheral blood mononuclear cells (PBMCs) stains approximately 30% of Foxp3+ cells, although studies have not confirmed higher suppressor activity in the human CD101+ population.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD101; Cell surface glycoprotein V7; EWI immunoglobulin subfamily member EWI-101; EWI-101; Glu-Trp-Ile EWI motif-containing protein 101; IgSF2; Immunoglobulin superfamily member 2; immunoglobulin superfamily, member 2; leukocyte surface protein; RP11-27K13.2
Gene Aliases: CD101; EWI-101; EWI101; Gm1016; Gm734; IGSF2; V7
UniProt ID: (Human) Q93033, (Mouse) A8E0Y8
Entrez Gene ID: (Human) 9398, (Mouse) 630146
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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