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Invitrogen
Phospho-Amyloid Precursor Protein (Thr668) Polyclonal Antibody
FIGURE: 1 / 2
Phospho-Amyloid Precursor Protein (Thr668) Antibody (PA5-97328) in WB
Western blot analysis of Phospho-Amyloid Precursor Protein (Thr668) in mouse brain. Samples were incubated with Phospho-Amyloid Precursor Protein (Thr668) Polyclonal antibody (Product # PA5-97328) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure ... View More
Product Details
PA5-97328
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphorylated peptide around T668 of human APP (NP_9588171)
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809130
Product Specific Information
Positive Samples: Mouse brain, Rat brain; Cellular Location: Membrane, Single-pass type I membrane protein, clathrin-coated pit
Immunogen sequence: AVTPE
Target Information
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABPP; AG; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta A4 protein; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloidogenic glycoprotein; APP; appican; Pan-Abeta; protease nexin II
Gene Aliases: A4; Abeta; Abpp; AD1; Adap; Ag; App; betaApp; Cvap; E030013M08Rik
UniProt ID: (Rat) P08592, (Mouse) P12023
Entrez Gene ID: (Rat) 54226, (Mouse) 11820
DNA binding
serine-type endopeptidase inhibitor activity
receptor binding
protein binding
heparin binding
peptidase activator activity
enzyme binding
acetylcholine receptor binding
identical protein binding
transition metal ion binding
PTB domain binding
growth factor receptor binding
peptidase inhibitor activity
metal ion binding
suckling behavior
mRNA polyadenylation
regulation of translation
protein phosphorylation
cellular copper ion homeostasis
endocytosis
response to oxidative stress
cell adhesion
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
axonogenesis
mating behavior
locomotory behavior
axo-dendritic transport
cholesterol metabolic process
adult locomotory behavior
visual learning
regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of peptidase activity
positive regulation of G2/M transition of mitotic cell cycle
axon midline choice point recognition
neuron remodeling
dendrite development
extracellular matrix organization
forebrain development
neuron projection development
ionotropic glutamate receptor signaling pathway
regulation of multicellular organism growth
regulation of protein binding
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting in absence of injury
regulation of synapse structure or activity
neuromuscular process controlling balance
synaptic growth at neuromuscular junction
neuron apoptotic process
smooth endoplasmic reticulum calcium ion homeostasis
apoptotic process
nervous system development
negative regulation of peptidase activity
protein homooligomerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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