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          • Primary Antibodies ›
          • STAT3 Antibodies
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          Invitrogen

          STAT3 Monoclonal Antibody (ST3-5G7)

          Advanced Verification
          9 Published Figures
          25 References
          View all (108) STAT3 antibodies

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          Datasheet
          Protocols
          Datasheet
          Protocols

          Cite STAT3 Monoclonal Antibody (ST3-5G7)

          • Antibody Testing Data (8)
          • Published Figures (9)
          • Advanced Verification (3)
          STAT3 Antibody in Immunocytochemistry (ICC/IF)
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          STAT3 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 20

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          STAT3 Antibody (13-7000) in ICC/IF

          Immunofluorescence analysis of STAT3 was performed using 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with STAT3 Mouse Monoclonal Antibody (Product # 13-7000) at 1:250 dilution in0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A2817... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          STAT3 Antibody in Immunocytochemistry (ICC/IF)
          STAT3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Gel Shift (GS)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in Western Blot (WB)
          STAT3 Antibody in ChIP Assay (ChIP)
          STAT3 Antibody in ChIP Assay (ChIP)
          STAT3 Antibody in ChIP Assay (ChIP)
          STAT3 Antibody in Gel Shift (GS)
          STAT3 Antibody
          STAT3 Antibody
          STAT3 Antibody

          Product Details

          13-7000

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          2 µg/mL
          View 10 publications 10 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:250
          -

          ELISA (ELISA)

          Assay-dependent
          -

          Immunoprecipitation (IP)

          Assay-dependent
          View 1 publication 1 publication

          ChIP assay (ChIP)

          Assay-dependent
          View 3 publications 3 publications

          ChIP-sequencing (ChIP-Seq)

          -
          View 1 publication 1 publication

          Gel Shift (GS)

          Assay-dependent
          View 4 publications 4 publications

          Miscellaneous PubMed (MISC)

          -
          View 5 publications 5 publications
          Product Specifications

          Published species

          Human, Mouse

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          ST3-5G7

          Immunogen

          A GST-fusion protein containing the unique carboxy terminal domain of the murine STAT3 protein.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice

          RRID

          AB_2533031

          Target Information

          STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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