Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Human CD30 Ligand/TNFSF8 quantitates human CD30 Ligand/TNFSF8 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD30 Ligand/TNFSF8.
The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : CD153, CD30L, CD30LG, TNFSF8, TNLG3A
Gene ID : (Human) 944
Gene symbol : TNFSF8
Protein Aliases : CD153, CD153 antigen, CD30 antigen ligand, CD30 ligand, CD30-L, CD30ligand, tumor necrosis factor (ligand) superfamily member 8, tumor necrosis factor (ligand) superfamily, member 8, tumor necrosis factor ligand 3A, Tumor necrosis factor ligand superfamily member 8
UniProt ID (Human) P32971
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