IL-21 ELISA Kits

ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for IL-21 are available for Human, Mouse, Bovine and Rabbit which can be quantified in various samples, including serum, supernatant, plasma.

Invitrogen ELISA kits exist in two... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for IL-21 are available for Human, Mouse, Bovine and Rabbit which can be quantified in various samples, including serum, supernatant, plasma.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated.... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for IL-21 are available for Human, Mouse, Bovine and Rabbit which can be quantified in various samples, including serum, supernatant, plasma.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for IL-21 are available for Human, Mouse, Bovine and Rabbit which can be quantified in various samples, including serum, supernatant, plasma.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits are ready-to-use and quality tested for sensitivity, specificity, precision and lot-to-lot consistency.

IL-21 detection is also available using highly-sensitive ProQuantum Immunoassays. These assays provide a fast, easy workflow with no wash steps, and are detectable with any real-time PCR instrument.

Can't find what you're looking for? Try the ELISA Builder to design your own assay based on target type and experimental needs. We also offer custom ELISA development services.

Target Information

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Synonyms

CVID11; CX2; il 21; Il21; IL-21; ILN; Interleukin; interleukin 21; interleukin 21-like; Interleukin21; interleukin-21; interleukin-21 isoform; LOC100344172; porcine interleukin-21; Za11

IL-21 ELISA Kits

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