Product References
BEST1 Positive Monocytes in Circulation: Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang L,Wang Y,Yuan W,An C,Tan Q,Ma J
300-11 was used in In vitro experiments to report that Bestrophin1 (BEST1), a component protein of Ca2+ -activated Cl- channels, is highly expressed on classical monocytes in the peripheral blood of Head and neck squamous cell carcinomas patients.
Thu Jun 01 00:00:00 UTC 2023
Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer.
Cancers
Baram T,Oren N,Erlichman N,Meshel T,Ben-Baruch A
300-11 was used in Enzyme-linked immunosorbent assay to suggest that in addition to its immune-suppressive activities, PD-L1 may promote disease course in TNBC by inhibiting the protective effects of sTNFR1 and sTNFR2.
Tue Jul 19 00:00:00 UTC 2022
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs.
Frontiers in cell and developmental biology
Ciummo SL,D'Antonio L,Sorrentino C,Fieni C,Lanuti P,Stassi G,Todaro M,Di Carlo E
300-11 was used in In vitro experiments to support that targeting the CXCL1/CXCR2 axis could restrain the BCSC compartment and improve the treatment of aggressive BC.
Tue Apr 02 00:00:00 UTC 2024
Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.
Cells
Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A
300-11 was used in Enzyme-linked immunosorbent assay to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.
Mon May 31 00:00:00 UTC 2021
A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer.
Molecular therapy : the journal of the American Society of Gene Therapy
Bertolini G,Cancila V,Milione M,Lo Russo G,Fortunato O,Zaffaroni N,Tortoreto M,Centonze G,Chiodoni C,Facchinetti F,Pollaci G,Taiè G,Giovinazzo F,Moro M,Camisaschi C,De Toma A,D'Alterio C,Pastorino U,Tripodo C,Scala S,Sozzi G,Roz L
300-11 was used in Cell Culture to reveal that activation of the CXCR4/SDF-1 axis specifically mediates the pro-metastatic effects of cisplatin and suggest CXCR4 blockade as a possible novel combination strategy to control metastatic disease.
Wed Oct 06 00:00:00 UTC 2021
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
Thu Aug 06 00:00:00 UTC 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
Thu Aug 06 00:00:00 UTC 2020
Oxidative stress enhanced the transforming growth factor-β2-induced epithelial-mesenchymal transition through chemokine ligand 1 on ARPE-19 cell.
Scientific reports
Yang IH,Lee JJ,Wu PC,Kuo HK,Kuo YH,Huang HM
Wed Mar 04 00:00:00 UTC 2020
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.
eLife
Somerville TD,Biffi G,Daßler-Plenker J,Hur SK,He XY,Vance KE,Miyabayashi K,Xu Y,Maia-Silva D,Klingbeil O,Demerdash OE,Preall JB,Hollingsworth MA,Egeblad M,Tuveson DA,Vakoc CR
300-11 was used in Cell Culture to reveal enhanced tissue inflammation as a consequence of squamous trans-differentiation in pancreatic cancer, thus highlighting an instructive role of tumor cell lineage in reprogramming the stromal microenvironment.
Fri Apr 24 00:00:00 UTC 2020
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 UTC 2019
TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.
Cell reports
Kasitinon SY,Eskiocak U,Martin M,Bezwada D,Khivansara V,Tasdogan A,Zhao Z,Mathews T,Aurora AB,Morrison SJ
300-11 was used in Cell Culture to determine that Mucolipin-1 is preferentially required for the survival and proliferation of melanoma cells.
Tue Aug 27 00:00:00 UTC 2019
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
Thu Oct 04 00:00:00 UTC 2018
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Virulence
Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG
300-11 was used in In vitro experiments to characterise the role of the three main cysteine proteases secreted by Giardia intestinalis in the development of Giardiasis.
Mon Dec 31 00:00:00 UTC 2018
Surveillance of Myelodysplastic Syndrome via Migration Analyses of Blood Neutrophils: A Potential Prognostic Tool.
Journal of immunology (Baltimore, Md. : 1950)
Schuster M,Moeller M,Bornemann L,Bessen C,Sobczak C,Schmitz S,Witjes L,Kruithoff K,Kohn C,Just O,Kündgen A,Pundt N,Pelzer B,Ampe C,Van Troys M,Nusch A,Haas R,Germing U,Martens L,Jöckel KH,Gunzer M
Sat Dec 15 00:00:00 UTC 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 UTC 2018
CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling.
Cell death & disease
Wang N,Liu W,Zheng Y,Wang S,Yang B,Li M,Song J,Zhang F,Zhang X,Wang Q,Wang Z
Wed Aug 29 00:00:00 UTC 2018
CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling.
Cell death & disease
Wang N,Liu W,Zheng Y,Wang S,Yang B,Li M,Song J,Zhang F,Zhang X,Wang Q,Wang Z
Wed Aug 29 00:00:00 UTC 2018
Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.
Nature communications
Taki M,Abiko K,Baba T,Hamanishi J,Yamaguchi K,Murakami R,Yamanoi K,Horikawa N,Hosoe Y,Nakamura E,Sugiyama A,Mandai M,Konishi I,Matsumura N
Fri Apr 27 00:00:00 UTC 2018
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 UTC 2017
Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets.
Journal of cellular physiology
Buskermolen JK,Roffel S,Gibbs S
Wed Nov 01 00:00:00 UTC 2017
Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis.
Journal of cellular and molecular medicine
Peng KY,Liu YH,Li YW,Yen BL,Yen ML
Tue Aug 01 00:00:00 UTC 2017
Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils.
Cellular microbiology
Lorenzini J,Scott Fites J,Nett J,Klein BS
300-11 was used in Sample Preparation (Mass Spectrometry) to investigate the effects of DppIVA on neutrophils recruitment.
Fri Sep 01 00:00:00 UTC 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 UTC 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 UTC 2017
Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite.
Nature communications
Dankwa S,Lim C,Bei AK,Jiang RH,Abshire JR,Patel SD,Goldberg JM,Moreno Y,Kono M,Niles JC,Duraisingh MT
Mon Apr 04 00:00:00 UTC 2016
GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment.
Nature communications
Song KH,Park MS,Nandu TS,Gadad S,Kim SC,Kim MY
Fri Dec 16 00:00:00 UTC 2016
Neutrophil priming occurs in a sequential manner and can be visualized in living animals by monitoring IL-1β promoter activation.
Journal of immunology (Baltimore, Md. : 1950)
Yao Y,Matsushima H,Ohtola JA,Geng S,Lu R,Takashima A
Sun Feb 01 00:00:00 UTC 2015
IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.
Nature communications
Wee ZN,Yatim SM,Kohlbauer VK,Feng M,Goh JY,Bao Y,Lee PL,Zhang S,Wang PP,Lim E,Tam WL,Cai Y,Ditzel HJ,Hoon DS,Tan EY,Yu Q
Tue Oct 27 00:00:00 UTC 2015
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Cancer cell
Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E
Mon May 12 00:00:00 UTC 2014
Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.
Journal of immunology (Baltimore, Md. : 1950)
Chen HW,Chen HY,Wang LT,Wang FH,Fang LW,Lai HY,Chen HH,Lu J,Hung MS,Cheng Y,Chen MY,Liu SJ,Chong P,Lee OK,Hsu SC
Wed May 15 00:00:00 UTC 2013
Host chemokines bind to Staphylococcus aureus and stimulate protein A release.
The Journal of biological chemistry
Yung SC,Parenti D,Murphy PM
Fri Feb 18 00:00:00 UTC 2011
Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.
PloS one
Zhao Y,Mangalmurti NS,Xiong Z,Prakash B,Guo F,Stolz DB,Lee JS
Mon May 21 00:00:00 UTC 2012
The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.
The Journal of biological chemistry
Lüttichau HR
Fri Mar 19 00:00:00 UTC 2010
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.
Nature medicine
Koenen RR,von Hundelshausen P,Nesmelova IV,Zernecke A,Liehn EA,Sarabi A,Kramp BK,Piccinini AM,Paludan SR,Kowalska MA,Kungl AJ,Hackeng TM,Mayo KH,Weber C
Thu Jan 01 00:00:00 UTC 2009
Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation.
Blood
Mangalmurti NS,Xiong Z,Hulver M,Ranganathan M,Liu XH,Oriss T,Fitzpatrick M,Rubin M,Triulzi D,Choi A,Lee JS
Thu Jan 29 00:00:00 UTC 2009
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Journal of immunology (Baltimore, Md. : 1950)
Abu-Taha M,Rius C,Hermenegildo C,Noguera I,Cerda-Nicolas JM,Issekutz AC,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Wed Jul 15 00:00:00 UTC 2009
Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
Journal of bacteriology
Bryan JD,Shelver DW
Sun Mar 01 00:00:00 UTC 2009
SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
PloS one
Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M
Mon Jun 15 00:00:00 UTC 2009
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 UTC 2007
Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.
Journal of immunology (Baltimore, Md. : 1950)
Carlos CA,Dong HF,Howard OM,Oppenheim JJ,Hanisch FG,Finn OJ
Mon Aug 01 00:00:00 UTC 2005
GRO family chemokines are specialized for monocyte arrest from flow.
American journal of physiology. Heart and circulatory physiology
Smith DF,Galkina E,Ley K,Huo Y
Tue Nov 01 00:00:00 UTC 2005
Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP
Thu Jan 15 00:00:00 UTC 2004
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America
Bertini R,Allegretti M,Bizzarri C,Moriconi A,Locati M,Zampella G,Cervellera MN,Di Cioccio V,Cesta MC,Galliera E,Martinez FO,Di Bitondo R,Troiani G,Sabbatini V,D'Anniballe G,Anacardio R,Cutrin JC,Cavalieri B,Mainiero F,Strippoli R,Villa P,Di Girolamo M,Martin F,Gentile M,Santoni A,Corda D,Poli G,Mantovani A,Ghezzi P,Colotta F
Tue Aug 10 00:00:00 UTC 2004
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins.
The Journal of biological chemistry
Rosenkilde MM,McLean KA,Holst PJ,Schwartz TW
Fri Jul 30 00:00:00 UTC 2004
Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.
The Journal of biological chemistry
Hirata T,Furukawa Y,Yang BG,Hieshima K,Fukuda M,Kannagi R,Yoshie O,Miyasaka M
Fri Dec 10 00:00:00 UTC 2004
Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration.
The Journal of experimental medicine
Chan JR,Hyduk SJ,Cybulsky MI
Mon May 21 00:00:00 UTC 2001
The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro.
Stem cells (Dayton, Ohio)
Majka M,Ratajczak J,Lee B,Honczarenko M,Douglas R,Kowalska MA,Silberstein L,Gewirtz AM,Ratajczak MZ
Mon Jun 26 00:00:00 UTC 2000
CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines.
The Journal of biological chemistry
Schweickart VL,Epp A,Raport CJ,Gray PW
Fri Mar 31 00:00:00 UTC 2000
Mast cell migratory response to interleukin-8 is mediated through interaction with chemokine receptor CXCR2/Interleukin-8RB.
Blood
Nilsson G,Mikovits JA,Metcalfe DD,Taub DD
Sat May 01 00:00:00 UTC 1999
Chemokines and the arrest of lymphocytes rolling under flow conditions.
Science (New York, N.Y.)
Campbell JJ,Hedrick J,Zlotnik A,Siani MA,Thompson DA,Butcher EC
Fri Jan 16 00:00:00 UTC 1998
Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
The Journal of experimental medicine
Power CA,Church DJ,Meyer A,Alouani S,Proudfoot AE,Clark-Lewis I,Sozzani S,Mantovani A,Wells TN
Mon Sep 15 00:00:00 UTC 1997
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
The Journal of experimental medicine
Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM
Mon Jul 07 00:00:00 UTC 1997
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
The Journal of experimental medicine
Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM
Mon Jul 07 00:00:00 UTC 1997
