Gibco

Human Flt-3 Ligand (FLT3L) Recombinant Protein, PeproTech®

Human Flt-3 Ligand (FLT3L) Protein in Functional Assay (Functional)

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Human Flt-3 Ligand (FLT3L) Protein (300-19-10UG) in Functional

Bioassay analysis of Human Flt-3 Ligand (FLT3L) Recombinant Protein, PeproTech® (Product # 300-19-1MG).

Product Image Gallery

Product Details

300-19-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 1 publication 1 publication

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 403 publications 403 publications

Miscellaneous PubMed (MISC)

View 42 publications 42 publications

Immunostaining (IS)

View 1 publication 1 publication

Product Specifications

Species

Human

Published species

Hamster, Human, Mouse, Non-human primate, Rabbit, Rat

Expression System

E. coli

Amino acid sequence

TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

Molecular weight

17.6 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 was determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

FLT3LG (Fms Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Brain Cancer. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.

Developmental cell

Fowler JL,Zheng SL,Nguyen A,Chen A,Xiong X,Chai T,Chen JY,Karigane D,Banuelos AM,Niizuma K,Kayamori K,Nishimura T,Cromer MK,Gonzalez-Perez D,Mason C,Liu DD,Yilmaz L,Miquerol L,Porteus MH,Luca VC,Majeti R,Nakauchi H,Red-Horse K,Weissman IL,Ang LT,Loh KM

300-19 was used in In vitro experiments to non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate hematopoietic stem cells.

Mon May 06 00:00:00 UTC 2024

Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth.

iScience

Xie X,Gou F,Zheng Z,Zhang Y,Zhang Y,Dong F,Cheng T,Cheng H

300-19 was used in Cell Culture to elucidate the dynamics of fetal hematopoiesis in preparation for birth, offering valuable insights into the pathological processes underlying leukemia.

Fri Aug 16 00:00:00 UTC 2024

Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.

The Journal of clinical investigation

Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG

300-19 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.

Thu Jun 01 00:00:00 UTC 2023

Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design.

iScience

Li YR,Ochoa CJ,Zhu Y,Kramer A,Wilson M,Fang Y,Chen Y,Singh T,Di Bernardo G,Zhu E,Lee D,Moatamed NA,Bando J,Zhou JJ,Memarzadeh S,Yang L

300-19 was used in In vitro experiments to we conducted a comprehensive analysis of primary tumor cells and their microenvironment from 16 chemonaive and 10 recurrent ovarian cancer (OC) patient samples.

Fri Oct 20 00:00:00 UTC 2023

The quality and quantity media-cultured mononuclear cell transplantation is safe and effective in ischemic hindlimb mouse model.

JVS-vascular science

Chinchalongporn W,Chruewkamlow N,Sermsathanasawadi N,Vorateera K,Jintaworn S,Wongwanit C,Ruangsetakit C

300-19 was used in Cell Culture to investigate in vitro proangiogenic and anti-inflammatory phenotypes and functions and the in vivo efficacy and safety of quality and quantity (QQ) media-cultured mononuclear cells (MNCs) compared with standard cultured MNCs from the peripheral blood of patients with chronic limb-threatening ischemia (CLTI) with atheosclerotic risk factors.

Tue Nov 14 00:00:00 UTC 2023

SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.

iScience

Wang D,Li Y,Xu C,Wang H,Huang X,Jin X,Ren S,Gao J,Tong J,Liu J,Zhou J,Shi L

300-19 was used in Cell Culture to find that deletion of SET domain containing 7 attenuated the generation of hematopoietic progenitor cells (HPCs) during the induction of hematopoietic differentiation from human embryonic stem cells (hESCs).

Fri Jun 16 00:00:00 UTC 2023

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.

Cell stem cell

Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X

300-19 was used in Cell Culture to show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.

Thu Jan 05 00:00:00 UTC 2023

Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology.

STAR protocols

Fan Y,Mizoguchi Y,Tatematsu M,Linder MI,Frenz S,Choi J,Klein C

300-19 was used in Cell Culture to describe a protocol to analyze and to quantify key parameters of mitochondrial respiration of iPSC-derived myeloid progenitors by the Seahorse XFe96 Analyzer.

Fri Mar 17 00:00:00 UTC 2023

SOX18-enforced expression diverts hemogenic endothelium-derived progenitors from T towards NK lymphoid pathways.

iScience

Jung HS,Suknuntha K,Kim YH,Liu P,Dettle ST,Sedzro DM,Smith PR,Thomson JA,Ong IM,Slukvin II

300-19 was used in In vitro experiments to reveal that SOX18 forced expression at the mesodermal stage, in contrast to its homolog SOX17, has minimal effects on arterial specification of hemogenic endothelium, expression of HOXA genes and lymphoid differentiation.

Fri May 19 00:00:00 UTC 2023

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

300-19 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 UTC 2023

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.

Nature

Casirati G,Cosentino A,Mucci A,Salah Mahmoud M,Ugarte Zabala I,Zeng J,Ficarro SB,Klatt D,Brendel C,Rambaldi A,Ritz J,Marto JA,Pellin D,Bauer DE,Armstrong SA,Genovese P

300-19 was used in In vitro experiments to show that multiplex epitope engineering of haematopoietic stem/progenitor cells is feasible and enables more effective immunotherapies against multiple targets without incurring overlapping off-tumour toxicities.

Fri Sep 01 00:00:00 UTC 2023

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.

Nature

Casirati G,Cosentino A,Mucci A,Salah Mahmoud M,Ugarte Zabala I,Zeng J,Ficarro SB,Klatt D,Brendel C,Rambaldi A,Ritz J,Marto JA,Pellin D,Bauer DE,Armstrong SA,Genovese P

Fri Sep 01 00:00:00 UTC 2023

Functional characterization of Alzheimer's disease genetic variants in microglia.

Nature genetics

Yang X,Wen J,Yang H,Jones IR,Zhu X,Liu W,Li B,Clelland CD,Luo W,Wong MY,Ren X,Cui X,Song M,Liu H,Chen C,Eng N,Ravichandran M,Sun Y,Lee D,Van Buren E,Jiang MZ,Chan CSY,Ye CJ,Perera RM,Gan L,Li Y,Shen Y

300-19 was used in In vitro experiments to show that AD variants exhibit allelic imbalance on target gene expression.

Sun Oct 01 00:00:00 UTC 2023

Disease-associated mutations in topoisomerase IIβ result in defective NK cells.

The Journal of allergy and clinical immunology

Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS

300-19 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.

Wed Jun 01 00:00:00 UTC 2022

A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.

Molecular therapy. Nucleic acids

Gray DH,Santos J,Keir AG,Villegas I,Maddock S,Trope EC,Long JD,Kuo CY

300-19 was used in Cell Culture to compare three methods of targeted insertion — homology-directed repair (HDR), homology-independent targeted integration (HITI), and precise integration into target chromosome (PITCh) — to achieve a permanent gene-therapy-based cure for X-linked agammaglobulinemia.

Tue Mar 08 00:00:00 UTC 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

300-19 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 UTC 2022

Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.

Frontiers in oncology

Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM

300-19 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.

Sat Jul 16 00:00:00 UTC 2022

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

RNA (New York, N.Y.)

Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF

300-19 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.

Thu Sep 01 00:00:00 UTC 2022

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.

Cell reports

Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F

300-19 was used in In vitro experiments to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.

Tue Aug 16 00:00:00 UTC 2022

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.

Cell reports

Chang Y,Syahirah R,Wang X,Jin G,Torregrosa-Allen S,Elzey BD,Hummel SN,Wang T,Li C,Lian X,Deng Q,Broxmeyer HE,Bao X

300-19 was used in Cell Culture to establish a robust platform for massive production of CAR neutrophils, paving the way to myeloid cell-based therapeutic strategies that would boost current cancer-treatment approaches.

Tue Jul 19 00:00:00 UTC 2022

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers.

iScience

Li YR,Zeng S,Dunn ZS,Zhou Y,Li Z,Yu J,Wang YC,Ku J,Cook N,Kramer A,Yang L

300-19 was used in In vitro experiments to report the successful generation of third-party HSC-engineered human iNKT (3rdHSC-iNKT) cells using a method combining HSC gene engineering and in vitro HSC differentiation.

Fri Sep 16 00:00:00 UTC 2022

A culture platform to study quiescent hematopoietic stem cells following genome editing.

Cell reports methods

Shiroshita K,Kobayashi H,Watanuki S,Karigane D,Sorimachi Y,Fujita S,Tamaki S,Haraguchi M,Itokawa N,Aoyoama K,Koide S,Masamoto Y,Kobayashi K,Nakamura-Ishizu A,Kurokawa M,Iwama A,Okamoto S,Kataoka K,Takubo K

300-19 was used in Cell Culture to analyze HSC cell cycle quiescence by combining culture conditions that maintain quiescence with a CRISPR-Cas9 genome editing system optimized for HSCs.

Mon Dec 19 00:00:00 UTC 2022

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.

iScience

van Gils N,Verhagen HJMP,Broux M,Martiáñez T,Denkers F,Vermue E,Rutten A,Csikós T,Demeyer S,Çil M,Al M,Cools J,Janssen JJWM,Ossenkoppele GJ,Menezes RX,Smit L

300-19 was used in Cell Culture to reveal plasticity of anthracycline resistance in AML cells and highlight the potential of transcriptional reprogramming by epigenetic-based therapeutics to target chemotherapy-resistant AML cells.

Fri Sep 16 00:00:00 UTC 2022

ZNF410 represses fetal globin by singular control of CHD4.

Nature genetics

Vinjamur DS,Yao Q,Cole MA,McGuckin C,Ren C,Zeng J,Hossain M,Luk K,Wolfe SA,Pinello L,Bauer DE

300-19 was used in Cell Culture to identify zinc-finger protein (ZNF) 410 as an fetal hemoglobin repressor.

Sat May 01 00:00:00 UTC 2021

N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

Cancer cell

Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG

300-19 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.

Mon Jul 12 00:00:00 UTC 2021

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.

Cancer discovery

Montefiori LE,Bendig S,Gu Z,Chen X,Pölönen P,Ma X,Murison A,Zeng A,Garcia-Prat L,Dickerson K,Iacobucci I,Abdelhamed S,Hiltenbrand R,Mead PE,Mehr CM,Xu B,Cheng Z,Chang TC,Westover T,Ma J,Stengel A,Kimura S,Qu C,Valentine MB,Rashkovan M,Luger S,Litzow MR,Rowe JM,den Boer ML,Wang V,Yin J,Kornblau SM,Hunger SP,Loh ML,Pui CH,Yang W,Crews KR,Roberts KG,Yang JJ,Relling MV,Evans WE,Stock W,Paietta EM,Ferrando AA,Zhang J,Kern W,Haferlach T,Wu G,Dick JE,Klco JM,Haferlach C,Mullighan CG

300-19 was used in In vitro experiments to identify oncogenic deregulation of BCL11B driven by diverse structural alterations, including de novo superenhancer generation, as the driving feature of a subset of lineage-ambiguous leukemias that transcend current diagnostic boundaries.

Mon Nov 01 00:00:00 UTC 2021

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

Cell stem cell

Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S

Thu Mar 04 00:00:00 UTC 2021

Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.

Cell stem cell

Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE

Thu May 06 00:00:00 UTC 2021

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.

Cell stem cell

Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ

Thu Nov 04 00:00:00 UTC 2021

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.

Cell stem cell

Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD

300-19 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.

Thu Jan 07 00:00:00 UTC 2021

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.

Cellular & molecular immunology

Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I

Thu Jul 01 00:00:00 UTC 2021

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Molecular cell

Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM

300-19 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.

Thu Jul 01 00:00:00 UTC 2021

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.

Science translational medicine

Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N

Wed Jun 16 00:00:00 UTC 2021

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Mon Feb 01 00:00:00 UTC 2021

Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

The Journal of experimental medicine

Le Coz C,Nguyen DN,Su C,Nolan BE,Albrecht AV,Xhani S,Sun D,Demaree B,Pillarisetti P,Khanna C,Wright F,Chen PA,Yoon S,Stiegler AL,Maurer K,Garifallou JP,Rymaszewski A,Kroft SH,Olson TS,Seif AE,Wertheim G,Grant SFA,Vo LT,Puck JM,Sullivan KE,Routes JM,Zakharova V,Shcherbina A,Mukhina A,Rudy NL,Hurst ACE,Atkinson TP,Boggon TJ,Hakonarson H,Abate AR,Hajjar J,Nicholas SK,Lupski JR,Verbsky J,Chinn IK,Gonzalez MV,Wells AD,Marson A,Poon GMK,Romberg N

Mon Jul 05 00:00:00 UTC 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 UTC 2021

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

Leukemia

Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM

Mon Nov 01 00:00:00 UTC 2021

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.

Molecular therapy. Nucleic acids

Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K

Fri Mar 05 00:00:00 UTC 2021

Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34⁺ cells by inhibiting AhR signalling.

Cell proliferation

Zhu X,Sun Q,Tan WS,Cai H

Mon Mar 01 00:00:00 UTC 2021

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.

Stem cells translational medicine

Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H

Tue Jun 01 00:00:00 UTC 2021

Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.

Blood advances

Zoccolillo M,Brigida I,Barzaghi F,Scala S,Hernández RJ,Basso-Ricci L,Colantuoni M,Pettinato E,Sergi LS,Milardi G,Capasso P,Lombardo A,Gregori S,Sanvito F,Schena F,Cesaro S,Conti F,Pession A,Benedetti F,Gattorno M,Lee PY,Naldini L,Cicalese MP,Aiuti A,Mortellaro A

Tue Aug 24 00:00:00 UTC 2021

Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C.

Blood advances

Li Y,Zhang W,Zhang Y,Ding Y,Yang M,He M,Liu X,Gu J,Xu S,Feng Z,Li Y,Yin J,Gao H,Song H,Xu H,Wang C,Ji Q,Ma S,Yang W,Yuan W,Xie XQ,Cheng T,Gao Y

Tue Sep 14 00:00:00 UTC 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 UTC 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 UTC 2021

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.

Stem cells international

Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS

Tue Jun 08 00:00:00 UTC 2021

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion

Cunningham S,Hackstein H

Tue Jun 01 00:00:00 UTC 2021

Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.

Cell reports

Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R

Tue Jun 22 00:00:00 UTC 2021

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.

Nature communications

Kennedy AL,Myers KC,Bowman J,Gibson CJ,Camarda ND,Furutani E,Muscato GM,Klein RH,Ballotti K,Liu S,Harris CE,Galvin A,Malsch M,Dale D,Gansner JM,Nakano TA,Bertuch A,Vlachos A,Lipton JM,Castillo P,Connelly J,Churpek J,Edwards JR,Hijiya N,Ho RH,Hofmann I,Huang JN,Keel S,Lamble A,Lau BW,Norkin M,Stieglitz E,Stock W,Walkovich K,Boettcher S,Brendel C,Fleming MD,Davies SM,Weller EA,Bahl C,Carter SL,Shimamura A,Lindsley RC

Fri Feb 26 00:00:00 UTC 2021

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.

STAR protocols

Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD

300-19 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.

Fri Dec 17 00:00:00 UTC 2021

Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.

Nature communications

Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL

Fri Mar 12 00:00:00 UTC 2021

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.

Cell reports. Medicine

Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L

300-19 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.

Tue Nov 16 00:00:00 UTC 2021

Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.

Communications biology

Barcia Durán JG,Lu T,Houghton S,Geng F,Schreiner R,Xiang J,Rafii S,Redmond D,Lis R

Thu Mar 25 00:00:00 UTC 2021

Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.

Cell reports

Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C

Tue Jan 12 00:00:00 UTC 2021

Methylation of dual-specificity phosphatase 4 controls cell differentiation.

Cell reports

Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X

Tue Jul 27 00:00:00 UTC 2021

CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data.

Nature communications

Amit I,Iancu O,Levy-Jurgenson A,Kurgan G,McNeill MS,Rettig GR,Allen D,Breier D,Ben Haim N,Wang Y,Anavy L,Hendel A,Yakhini Z

Mon May 24 00:00:00 UTC 2021

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.

Communications biology

Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S

Mon Jun 07 00:00:00 UTC 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Nature protocols

Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R

300-19 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.

Mon Feb 01 00:00:00 UTC 2021

Directly reprogrammed natural killer cells for cancer immunotherapy.

Nature biomedical engineering

Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS

Mon Nov 01 00:00:00 UTC 2021

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

Nature communications

Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A

Thu Nov 25 00:00:00 UTC 2021

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.

Scientific reports

Hofmans M,Lammens T,Depreter B,Wu Y,Erlacher M,Caye A,Cavé H,Flotho C,de Haas V,Niemeyer CM,Stary J,Van Nieuwerburgh F,Deforce D,Van Loocke W,Van Vlierberghe P,Philippé J,De Moerloose B

Tue Feb 02 00:00:00 UTC 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications

Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM

Mon Mar 01 00:00:00 UTC 2021

Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.

Molecular therapy. Methods & clinical development

Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ

Fri Mar 12 00:00:00 UTC 2021

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.

Nature communications

Biavasco R,Lettera E,Giannetti K,Gilioli D,Beretta S,Conti A,Scala S,Cesana D,Gallina P,Norelli M,Basso-Ricci L,Bondanza A,Cavalli G,Ponzoni M,Dagna L,Doglioni C,Aiuti A,Merelli I,Di Micco R,Montini E

Tue Jul 27 00:00:00 UTC 2021

Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.

Cell stem cell

Tong J,Sun T,Ma S,Zhao Y,Ju M,Gao Y,Zhu P,Tan P,Fu R,Zhang A,Wang D,Wang D,Xiao Z,Zhou J,Yang R,Loughran SJ,Li J,Green AR,Bresnick EH,Wang D,Cheng T,Zhang L,Shi L

Thu Mar 04 00:00:00 UTC 2021

NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.

Stem cell reports

Araki D,Fu JF,Huntsman H,Cordes S,Seifuddin F,Alvarado LJ,Cheruku PS,Cash A,Traba J,Li Y,Pirooznia M,Smith RH,Larochelle A

Tue Sep 14 00:00:00 UTC 2021

In vitro expansion of fetal liver hematopoietic stem cells.

Scientific reports

Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V

Fri Jun 04 00:00:00 UTC 2021

The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.

Cell reports

Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H

Tue Apr 27 00:00:00 UTC 2021

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.

iScience

Zee BM,Poels KE,Yao CH,Kawabata KC,Wu G,Duy C,Jacobus WD,Senior E,Endress JE,Jambhekar A,Lovitch SB,Ma J,Dhall A,Harris IS,Blanco MA,Sykes DB,Licht JD,Weinstock DM,Melnick A,Haigis MC,Michor F,Shi Y

Fri Jun 25 00:00:00 UTC 2021

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.

Stem cell research & therapy

Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N

300-19 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.

Tue Sep 28 00:00:00 UTC 2021

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.

Scientific reports

Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS

Fri Mar 05 00:00:00 UTC 2021

The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.

Frontiers in immunology

Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E

300-19 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.

Mon Dec 27 00:00:00 UTC 2021

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.

Science advances

Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG

300-19 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).

Fri Jan 01 00:00:00 UTC 2021

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.

Cell reports

Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II

300-19 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.

Tue Feb 16 00:00:00 UTC 2021

The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.

Nature communications

Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R

Wed Jan 20 00:00:00 UTC 2021

Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.

Scientific reports

Marx-Blümel L,Marx C,Sonnemann J,Weise F,Hampl J,Frey J,Rothenburger L,Cirri E,Rahnis N,Koch P,Groth M,Schober A,Wang ZQ,Beck JF

Wed Oct 27 00:00:00 UTC 2021

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.

Nature communications

Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A

Fri Aug 13 00:00:00 UTC 2021

Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells.

Cell death & disease

Malyukova A,Ujvari D,Yektaei-Karin E,Zovko A,Madapura HS,Keszei M,Nagy N,Lotfi K,Björn N,Wallvik J,Tamai M,Nguyen TTT,Akahane K,Inukai T,Stenke L,Salamon D

Sat Sep 25 00:00:00 UTC 2021

Dyshomeostatic modulation of Ca²⁺-activated K⁺ channels in a human neuronal model of KCNQ2 encephalopathy.

eLife

Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E

300-19 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.

Fri Feb 05 00:00:00 UTC 2021

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.

Nature

Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP

Tue Sep 01 00:00:00 UTC 2020

Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.

Immunity

Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C

Tue Jun 16 00:00:00 UTC 2020

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nature genetics

Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC

300-19 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).

Wed Apr 01 00:00:00 UTC 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

Mon Jul 13 00:00:00 UTC 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Mon Jul 13 00:00:00 UTC 2020

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.

Cancer discovery

Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A

300-19 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.

Tue Dec 01 00:00:00 UTC 2020

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.

Blood

Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR

Thu Jan 02 00:00:00 UTC 2020

Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.

Blood

Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J

Thu Nov 05 00:00:00 UTC 2020

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency.

Blood

Grey W,Chauhan R,Piganeau M,Huerga Encabo H,Garcia-Albornoz M,McDonald NQ,Bonnet D

Thu Nov 26 00:00:00 UTC 2020

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.

Blood

Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG

Thu Aug 27 00:00:00 UTC 2020

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.

Blood

Subramaniam A,Žemaitis K,Talkhoncheh MS,Yudovich D,Bäckström A,Debnath S,Chen J,Jain MV,Galeev R,Gaetani M,Zubarev RA,Larsson J

Thu Nov 05 00:00:00 UTC 2020

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.

Cell stem cell

Nagpal N,Wang J,Zeng J,Lo E,Moon DH,Luk K,Braun RO,Burroughs LM,Keel SB,Reilly C,Lindsley RC,Wolfe SA,Tai AK,Cahan P,Bauer DE,Fong YW,Agarwal S

300-19 was used in Cell Culture to describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo.

Thu Jun 04 00:00:00 UTC 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

300-19 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 UTC 2020

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.

Cell stem cell

Jones CL,Stevens BM,Pollyea DA,Culp-Hill R,Reisz JA,Nemkov T,Gehrke S,Gamboni F,Krug A,Winters A,Pei S,Gustafson A,Ye H,Inguva A,Amaya M,Minhajuddin M,Abbott D,Becker MW,DeGregori J,Smith CA,D'Alessandro A,Jordan CT

300-19 was used in Tissue/organ culture to demonstrate that elevated nicotinamide metabolism is both the mechanistic basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.

Thu Nov 05 00:00:00 UTC 2020

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.

The Journal of clinical investigation

N'diaye M,Brauner S,Flytzani S,Kular L,Warnecke A,Adzemovic MZ,Piket E,Min JH,Edwards W,Mela F,Choi HY,Magg V,James T,Linden M,Reichardt HM,Daws MR,van Horssen J,Kockum I,Harris RA,Olsson T,Guerreiro-Cacais AO,Jagodic M

Mon Feb 03 00:00:00 UTC 2020

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.

The Journal of experimental medicine

Freund EC,Lock JY,Oh J,Maculins T,Delamarre L,Bohlen CJ,Haley B,Murthy A

Mon Jul 06 00:00:00 UTC 2020

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.

The Journal of experimental medicine

Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z

Mon Feb 03 00:00:00 UTC 2020

Real-Time NMR Spectroscopy for Studying Metabolism.

Angewandte Chemie (International ed. in English)

Alshamleh I,Krause N,Richter C,Kurrle N,Serve H,Günther UL,Schwalbe H

Mon Feb 03 00:00:00 UTC 2020

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.

Developmental cell

Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE

300-19 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.

Mon Oct 26 00:00:00 UTC 2020

Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America

Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ

Tue May 19 00:00:00 UTC 2020

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

Proceedings of the National Academy of Sciences of the United States of America

Qiao X,van der Zanden SY,Wander DPA,Borràs DM,Song JY,Li X,van Duikeren S,van Gils N,Rutten A,van Herwaarden T,van Tellingen O,Giacomelli E,Bellin M,Orlova V,Tertoolen LGJ,Gerhardt S,Akkermans JJ,Bakker JM,Zuur CL,Pang B,Smits AM,Mummery CL,Smit L,Arens R,Li J,Overkleeft HS,Neefjes J

Tue Jun 30 00:00:00 UTC 2020

Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws.

Proceedings of the National Academy of Sciences of the United States of America

Schmiderer L,Subramaniam A,Žemaitis K,Bäckström A,Yudovich D,Soboleva S,Galeev R,Prinz CN,Larsson J,Hjort M

Tue Sep 01 00:00:00 UTC 2020

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Proceedings of the National Academy of Sciences of the United States of America

Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A

Tue Jul 28 00:00:00 UTC 2020

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.

Oncogene

Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA

Wed Apr 01 00:00:00 UTC 2020

Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34⁺ cells via inhibition of senescence.

Stem cells translational medicine

Li X,Ma X,Chen Y,Peng D,Wang H,Chen S,Xiao Y,Li L,Zhou H,Cheng F,Gao Y,Chang J,Cheng T,Liu L

Tue Dec 01 00:00:00 UTC 2020

Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response.

Oncogenesis

Giuli MV,Diluvio G,Giuliani E,Franciosa G,Di Magno L,Pignataro MG,Tottone L,Nicoletti C,Besharat ZM,Peruzzi G,Pelullo M,Palermo R,Canettieri G,Talora C,d'Amati G,Bellavia D,Screpanti I,Checquolo S

Sun Oct 18 00:00:00 UTC 2020

EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dong XM,Zhao K,Zheng WW,Xu CW,Zhang MJ,Yin RH,Gao R,Tang LJ,Liu JF,Chen H,Zhan YQ,Yu M,Ge CH,Gao HY,Li X,Luo T,Ning HM,Yang XM,Li CY

Mon Jun 01 00:00:00 UTC 2020

Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling.

Cell reports

Sinha S,Biswas M,Chatterjee SS,Kumar S,Sengupta A

300-19 was used in Cell Culture to study the molecular integration of developmental signaling with mesenchymal-stromal-cell (MSC) intrinsic chromatin regulation. To reveal a link illustrating epi-genomic feedforward control of bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling to transcriptional and cellular plasticity in the mesenchymal microenvironment and account for stromal-SWI/SNF in hematopoiesis.

Tue Apr 28 00:00:00 UTC 2020

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.

Nature communications

Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M

Fri Jan 10 00:00:00 UTC 2020

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.

Cell death & disease

Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA

Fri Aug 14 00:00:00 UTC 2020

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.

Stem cell reports

Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM

Tue Feb 11 00:00:00 UTC 2020

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System.

Molecular therapy. Methods & clinical development

Shapiro J,Iancu O,Jacobi AM,McNeill MS,Turk R,Rettig GR,Amit I,Tovin-Recht A,Yakhini Z,Behlke MA,Hendel A

Fri Jun 12 00:00:00 UTC 2020

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.

Stem cell reports

Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A

Tue Jan 14 00:00:00 UTC 2020

Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.

Communications biology

Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S

Fri Dec 18 00:00:00 UTC 2020

Establishment of a Long-Term Co-culture Assay for Mesenchymal Stromal Cells and Hematopoietic Stem/Progenitors.

STAR protocols

Sinha S,Chakraborty S,Sengupta A

Fri Dec 18 00:00:00 UTC 2020

Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.

STAR protocols

Ryan SK,Jordan-Sciutto KL,Anderson SA

Fri Dec 18 00:00:00 UTC 2020

Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome.

Nature communications

Rai R,Romito M,Rivers E,Turchiano G,Blattner G,Vetharoy W,Ladon D,Andrieux G,Zhang F,Zinicola M,Leon-Rico D,Santilli G,Thrasher AJ,Cavazza A

Wed Aug 12 00:00:00 UTC 2020

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.

Cells

Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N

300-19 was used in In vitro experiments to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.

Wed Feb 19 00:00:00 UTC 2020

Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.

Nature communications

Thornton N,Karamatic Crew V,Tilley L,Green CA,Tay CL,Griffiths RE,Singleton BK,Spring F,Walser P,Alattar AG,Jones B,Laundy R,Storry JR,Möller M,Wall L,Charlewood R,Westhoff CM,Lomas-Francis C,Yahalom V,Feick U,Seltsam A,Mayer B,Olsson ML,Anstee DJ

Thu Jul 16 00:00:00 UTC 2020

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141⁺ dendritic cells to activate naïve and memory WT1-specific CD8⁺ T cells.

Clinical & translational immunology

Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ

Fri Apr 26 00:00:00 UTC 2024

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J

Fri Jun 12 00:00:00 UTC 2020

Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.

Bio-protocol

Chen IP

300-19 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.

Sun Dec 20 00:00:00 UTC 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

300-19 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 UTC 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

300-19 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 UTC 2020

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.

Immunity

Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H

Tue Nov 19 00:00:00 UTC 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

300-19 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.

Mon Apr 15 00:00:00 UTC 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

300-19 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.

Mon Apr 15 00:00:00 UTC 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

Cancer cell

Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH

Mon Aug 12 00:00:00 UTC 2019

IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.

Blood

González-García S,Mosquera M,Fuentes P,Palumbo T,Escudero A,Pérez-Martínez A,Ramírez M,Corcoran AE,Toribio ML

Thu Dec 12 00:00:00 UTC 2019

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.

Blood

Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS

Thu May 30 00:00:00 UTC 2019

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Blood

Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A

Thu May 09 00:00:00 UTC 2019

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.

Blood

Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S

Thu Jul 11 00:00:00 UTC 2019

Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell stem cell

Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L

300-19 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.

Thu Oct 03 00:00:00 UTC 2019

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.

Science translational medicine

Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM

300-19 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.

Wed Oct 30 00:00:00 UTC 2019

Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity.

The Journal of experimental medicine

Medina BD,Liu M,Vitiello GA,Seifert AM,Zeng S,Bowler T,Zhang JQ,Cavnar MJ,Loo JK,Param NJ,Maltbaek JH,Rossi F,Balachandran V,DeMatteo RP

Mon Jun 03 00:00:00 UTC 2019

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

The Journal of experimental medicine

Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP

Mon Dec 02 00:00:00 UTC 2019

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.

Leukemia

Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P

Mon Jul 01 00:00:00 UTC 2019

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America

Wang KW,Zhan X,McAlpine W,Zhang Z,Choi JH,Shi H,Misawa T,Yue T,Zhang D,Wang Y,Ludwig S,Russell J,Tang M,Li X,Murray AR,Moresco EMY,Turer EE,Beutler B

Tue Jun 04 00:00:00 UTC 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

300-19 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 UTC 2019

Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.

Antioxidants & redox signaling

Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI

300-19 was used in Cell Culture to investigate if HIF-1α protects hematopoietic stem cells against ROS.

Sat Jul 20 00:00:00 UTC 2019

Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.

Stem cells (Dayton, Ohio)

Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB

Fri Feb 01 00:00:00 UTC 2019

Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.

Stem cells (Dayton, Ohio)

Abu-Khader A,Law KW,Jahan S,Manesia JK,Pasha R,Hovey O,Pineault N

Fri Mar 01 00:00:00 UTC 2019

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.

Nature communications

Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L

Mon Jun 03 00:00:00 UTC 2019

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.

Cell stem cell

Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB

300-19 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.

Thu Feb 07 00:00:00 UTC 2019

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Nature communications

Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP

Tue Jul 02 00:00:00 UTC 2019

Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Nature communications

Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T

Fri Dec 06 00:00:00 UTC 2019

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.

Scientific reports

Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL

Thu Nov 14 00:00:00 UTC 2019

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nature communications

Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA

Fri Jan 04 00:00:00 UTC 2019

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Nature communications

Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R

Mon Nov 25 00:00:00 UTC 2019

Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice.

Scientific reports

Radtke S,Görgens A,da Conceição Castro SV,Kordelas L,Köninger A,Dürig J,Möllmann M,Horn PA,Giebel B

Mon Sep 09 00:00:00 UTC 2019

Mesenchymal stem cell therapy induces FLT3L and CD1c⁺ dendritic cells in systemic lupus erythematosus patients.

Nature communications

Yuan X,Qin X,Wang D,Zhang Z,Tang X,Gao X,Chen W,Sun L

Fri Jun 07 00:00:00 UTC 2019

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.

Scientific reports

Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II

Mon Apr 29 00:00:00 UTC 2019

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.

Nature medicine

Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA

300-19 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.

Wed Aug 01 00:00:00 UTC 2018

Regulation of embryonic haematopoietic multipotency by EZH1.

Nature

Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ

Thu Jan 25 00:00:00 UTC 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S

Thu May 31 00:00:00 UTC 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Thu May 31 00:00:00 UTC 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Cell

Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH

Thu Jun 28 00:00:00 UTC 2018

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.

Cell

Guzzi N,Cieśla M,Ngoc PCT,Lang S,Arora S,Dimitriou M,Pimková K,Sommarin MNE,Munita R,Lubas M,Lim Y,Okuyama K,Soneji S,Karlsson G,Hansson J,Jönsson G,Lund AH,Sigvardsson M,Hellström-Lindberg E,Hsieh AC,Bellodi C

Thu May 17 00:00:00 UTC 2018

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 UTC 2018

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m⁶A/MYC/CEBPA Signaling.

Cell

Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J

Thu Jan 11 00:00:00 UTC 2018

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Immunity

Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV

Tue Jun 19 00:00:00 UTC 2018

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Cancer cell

Jones CL,Stevens BM,D'Alessandro A,Reisz JA,Culp-Hill R,Nemkov T,Pei S,Khan N,Adane B,Ye H,Krug A,Reinhold D,Smith C,DeGregori J,Pollyea DA,Jordan CT

Mon Nov 12 00:00:00 UTC 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Cell stem cell

Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

300-19 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.

Thu Dec 06 00:00:00 UTC 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Cell stem cell

Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

300-19 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.

Thu Dec 06 00:00:00 UTC 2018

Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.

The Journal of experimental medicine

Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A

Mon Feb 05 00:00:00 UTC 2018

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Developmental cell

Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T

300-19 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.

Mon Feb 05 00:00:00 UTC 2018

Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells.

Stem cells translational medicine

Tanaka R,Masuda H,Fujimura S,Ito-Hirano R,Arita K,Kakinuma Y,Hagiwara H,Kado M,Hayashi A,Mita T,Ogawa T,Watada H,Mizuno H,Sawada N,Asahara T

Tue May 01 00:00:00 UTC 2018

X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.

Molecular oncology

Zhou J,Lu X,Tan TZ,Chng WJ

Mon Jan 01 00:00:00 UTC 2018

The Essential Role of Double-Stranded RNA-Dependent Antiviral Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells.

Journal of immunology (Baltimore, Md. : 1950)

Kimura S,Matsumiya T,Shiba Y,Nakanishi M,Hayakari R,Kawaguchi S,Yoshida H,Imaizumi T

Wed Aug 01 00:00:00 UTC 2018

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Nature communications

Stevens BM,Khan N,D'Alessandro A,Nemkov T,Winters A,Jones CL,Zhang W,Pollyea DA,Jordan CT

Wed Sep 12 00:00:00 UTC 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 UTC 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 UTC 2018

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.

Nature communications

Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F

Fri May 18 00:00:00 UTC 2018

Reconstruction of complex single-cell trajectories using CellRouter.

Nature communications

Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ

Thu Mar 01 00:00:00 UTC 2018

Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.

Cell death & disease

Li Z,Li SP,Li RY,Zhu H,Liu X,Guo XL,Mu LL,Cai JJ,Bai F,Chen GQ,Hong DL

Tue May 01 00:00:00 UTC 2018

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.

Cell death & disease

Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H

Tue Sep 11 00:00:00 UTC 2018

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.

Cell reports

Osorio FG,Rosendahl Huber A,Oka R,Verheul M,Patel SH,Hasaart K,de la Fonteijne L,Varela I,Camargo FD,van Boxtel R

300-19 was used in Cell Culture to perform genomic analysis of the mutation accumulation of HSPCs.

Tue Nov 27 00:00:00 UTC 2018

Human granulocytes undergo cell death via autophagy.

Cell death discovery

Kajiume T,Kobayashi M

Wed Oct 04 00:00:00 UTC 2023

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

Nature communications

Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR

Thu Aug 30 00:00:00 UTC 2018

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.

Stem cell reports

Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P

Tue Oct 09 00:00:00 UTC 2018

Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.

Scientific reports

DeRosa BA,El Hokayem J,Artimovich E,Garcia-Serje C,Phillips AW,Van Booven D,Nestor JE,Wang L,Cuccaro ML,Vance JM,Pericak-Vance MA,Cukier HN,Nestor MW,Dykxhoorn DM

Wed May 30 00:00:00 UTC 2018

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.

Nature communications

Sheng C,Jungverdorben J,Wiethoff H,Lin Q,Flitsch LJ,Eckert D,Hebisch M,Fischer J,Kesavan J,Weykopf B,Schneider L,Holtkamp D,Beck H,Till A,Wüllner U,Ziller MJ,Wagner W,Peitz M,Brüstle O

Tue Oct 02 00:00:00 UTC 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 UTC 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

300-19 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 UTC 2018

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.

Stem cell reports

Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S

Tue Jun 05 00:00:00 UTC 2018

Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.

Scientific reports

Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M

Tue Apr 17 00:00:00 UTC 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

300-19 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.

Tue Aug 14 00:00:00 UTC 2018

Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.

Nature communications

Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W

Tue Sep 25 00:00:00 UTC 2018

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.

Nature communications

Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R

Wed Aug 29 00:00:00 UTC 2018

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Stem cell reports

Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V

Tue Nov 13 00:00:00 UTC 2018

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Nature communications

Latham SL,Ehmke N,Reinke PYA,Taft MH,Eicke D,Reindl T,Stenzel W,Lyons MJ,Friez MJ,Lee JA,Hecker R,Frühwald MC,Becker K,Neuhann TM,Horn D,Schrock E,Niehaus I,Sarnow K,Grützmann K,Gawehn L,Klink B,Rump A,Chaponnier C,Figueiredo C,Knöfler R,Manstein DJ,Di Donato N

Fri Oct 12 00:00:00 UTC 2018

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.

The Journal of biological chemistry

Seren S,Rashed Abouzaid M,Eulenberg-Gustavus C,Hirschfeld J,Nasr Soliman H,Jerke U,N'Guessan K,Dallet-Choisy S,Lesner A,Lauritzen C,Schacher B,Eickholz P,Nagy N,Szell M,Croix C,Viaud-Massuard MC,Al Farraj Aldosari A,Ragunatha S,Ibrahim Mostafa M,Giampieri F,Battino M,Cornillier H,Lorette G,Stephan JL,Goizet C,Pedersen J,Gauthier F,Jenne DE,Marchand-Adam S,Chapple IL,Kettritz R,Korkmaz B

Fri Aug 10 00:00:00 UTC 2018

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.

Nature

Raffel S,Falcone M,Kneisel N,Hansson J,Wang W,Lutz C,Bullinger L,Poschet G,Nonnenmacher Y,Barnert A,Bahr C,Zeisberger P,Przybylla A,Sohn M,Tönjes M,Erez A,Adler L,Jensen P,Scholl C,Fröhling S,Cocciardi S,Wuchter P,Thiede C,Flörcken A,Westermann J,Ehninger G,Lichter P,Hiller K,Hell R,Herrmann C,Ho AD,Krijgsveld J,Radlwimmer B,Trumpp A

Thu Nov 16 00:00:00 UTC 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell

Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ

Thu Feb 23 00:00:00 UTC 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cell

Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A

Thu May 18 00:00:00 UTC 2017

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

Cell

Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I

Thu Sep 07 00:00:00 UTC 2017

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cell

Cantor JR,Abu-Remaileh M,Kanarek N,Freinkman E,Gao X,Louissaint A,Lewis CA,Sabatini DM

Thu Apr 06 00:00:00 UTC 2017

Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification.

Immunity

Grajkowska LT,Ceribelli M,Lau CM,Warren ME,Tiniakou I,Nakandakari Higa S,Bunin A,Haecker H,Mirny LA,Staudt LM,Reizis B

Tue Jan 17 00:00:00 UTC 2017

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR

Mon Nov 13 00:00:00 UTC 2017

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR

Mon Nov 13 00:00:00 UTC 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T

Mon Apr 10 00:00:00 UTC 2017

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer cell

Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P

Mon Jun 12 00:00:00 UTC 2017

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.

Blood

Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B

Thu Dec 21 00:00:00 UTC 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy

Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y

300-19 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.

Thu May 04 00:00:00 UTC 2017

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Stem cells translational medicine

Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP

Wed Mar 01 00:00:00 UTC 2017

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Stem cells translational medicine

Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP

Wed Mar 01 00:00:00 UTC 2017

Curtailed T-cell activation curbs effector differentiation and generates CD8⁺ T cells with a naturally-occurring memory stem cell phenotype.

European journal of immunology

Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E

Fri Sep 01 00:00:00 UTC 2017

CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.

Journal of immunology (Baltimore, Md. : 1950)

Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N

Sun Oct 01 00:00:00 UTC 2017

Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34⁺ cells.

Cell cycle (Georgetown, Tex.)

Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L

300-19 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.

Fri May 19 00:00:00 UTC 2017

Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.

Bio-protocol

Sontag S,Förster M,Seré K,Zenke M

300-19 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.

Sat Aug 05 00:00:00 UTC 2017

KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.

Nature communications

Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

Fri Nov 10 00:00:00 UTC 2017

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.

EBioMedicine

Hayashi M,Aoshi T,Haseda Y,Kobiyama K,Wijaya E,Nakatsu N,Igarashi Y,Standley DM,Yamada H,Honda-Okubo Y,Hara H,Saito T,Takai T,Coban C,Petrovsky N,Ishii KJ

300-19 was used in In vitro experiments to study the immunological characteristics and mechanism of action of delta inulin-derived microparticle Advax.

Wed Feb 01 00:00:00 UTC 2017

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.

Stem cell reports

Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D

Tue Jul 11 00:00:00 UTC 2017

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.

Oncoimmunology

Van Caeneghem Y,De Munter S,Tieppo P,Goetgeluk G,Weening K,Verstichel G,Bonte S,Taghon T,Leclercq G,Kerre T,Debets R,Vermijlen D,Abken H,Vandekerckhove B

300-19 was used in Flow cytometry/Cell sorting to show that cord blood hematopoietic progenitor cells generate allogeneic CD3-antigen receptor (AR)+T cells which effectively eliminate malignant cells and limit graft versus host disease occurrence.

Tue Jan 12 00:00:00 UTC 2021

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Stem cell reports

Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK

Tue Sep 12 00:00:00 UTC 2017

Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.

Stem cell reports

Zeng J,Tang SY,Toh LL,Wang S

Tue Dec 12 00:00:00 UTC 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Fri Sep 29 00:00:00 UTC 2017

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.

Oncotarget

Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P

300-19 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.

Tue Dec 05 00:00:00 UTC 2017

Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.

ACS biomaterials science & engineering

Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ

300-19 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.

Mon Dec 11 00:00:00 UTC 2017

Enforced GFI1 expression impedes human and murine leukemic cell growth.

Scientific reports

Hönes JM,Thivakaran A,Botezatu L,Patnana P,Castro SVDC,Al-Matary YS,Schütte J,Fischer KBI,Vassen L,Görgens A,Dührsen U,Giebel B,Khandanpour C

Thu Nov 16 00:00:00 UTC 2017

TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.

Scientific reports

Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML

Mon Oct 16 00:00:00 UTC 2017

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.

Nature communications

Veglia F,Tyurin VA,Mohammadyani D,Blasi M,Duperret EK,Donthireddy L,Hashimoto A,Kapralov A,Amoscato A,Angelini R,Patel S,Alicea-Torres K,Weiner D,Murphy ME,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI

Thu Dec 14 00:00:00 UTC 2017

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.

Nature biotechnology

Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR

300-19 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.

Tue Nov 01 00:00:00 UTC 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell

Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL

Thu Apr 07 00:00:00 UTC 2016

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

Immunity

Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J

Tue Aug 16 00:00:00 UTC 2016

Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.

Blood

Chesnais V,Renneville A,Toma A,Lambert J,Passet M,Dumont F,Chevret S,Lejeune J,Raimbault A,Stamatoullas A,Rose C,Beyne-Rauzy O,Delaunay J,Solary E,Fenaux P,Dreyfus F,Preudhomme C,Kosmider O,Fontenay M

Thu Feb 11 00:00:00 UTC 2016

UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

Blood

Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G

Thu May 26 00:00:00 UTC 2016

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Blood

Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J

Thu Jan 28 00:00:00 UTC 2016

Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.

The Journal of clinical investigation

Sanges D,Simonte G,Di Vicino U,Romo N,Pinilla I,Nicolás M,Cosma MP

Mon Aug 01 00:00:00 UTC 2016

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation

Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J

Thu Dec 01 00:00:00 UTC 2016

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

The Journal of experimental medicine

Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG

Mon Nov 14 00:00:00 UTC 2016

Targeting MTHFD2 in acute myeloid leukemia.

The Journal of experimental medicine

Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K

Mon Jun 27 00:00:00 UTC 2016

Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease.

Experimental & molecular medicine

Son MY,Lee MO,Jeon H,Seol B,Kim JH,Chang JS,Cho YS

Fri May 13 00:00:00 UTC 2016

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

Stem cells translational medicine

Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM

300-19 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.

Mon Aug 01 00:00:00 UTC 2016

Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation.

Stem cells (Dayton, Ohio)

Hoffmann D,Göhring G,Heuser M,Ganser A,Schambach A,Morgan MA

Tue Mar 01 00:00:00 UTC 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 UTC 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 UTC 2016

Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice.

Journal of immunology (Baltimore, Md. : 1950)

von Wnuck Lipinski K,Sattler K,Peters S,Weske S,Keul P,Klump H,Heusch G,Göthert JR,Levkau B

Mon Feb 15 00:00:00 UTC 2016

CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.

Cell cycle (Georgetown, Tex.)

Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A

300-19 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.

Mon May 02 00:00:00 UTC 2016

RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.

Scientific reports

Hayashi M,Aoshi T,Ozasa K,Kusakabe T,Momota M,Haseda Y,Kobari S,Kuroda E,Kobiyama K,Coban C,Ishii KJ

Mon Jul 04 00:00:00 UTC 2016

Acetylation of C/EBPα inhibits its granulopoietic function.

Nature communications

Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG

Wed Mar 23 00:00:00 UTC 2016

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

Nature communications

Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK

Mon Aug 08 00:00:00 UTC 2016

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem cell reports

D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II

Tue Feb 09 00:00:00 UTC 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 UTC 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 UTC 2016

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Nature communications

Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP

Thu Oct 20 00:00:00 UTC 2016

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.

Cell death & disease

Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R

Thu Apr 07 00:00:00 UTC 2016

Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus.

Scientific reports

Uematsu T,Fujita T,Nakaoka HJ,Hara T,Kobayashi N,Murakami Y,Seiki M,Sakamoto T

Thu Nov 24 00:00:00 UTC 2016

Chromothriptic cure of WHIM syndrome.

Cell

McDermott DH,Gao JL,Liu Q,Siwicki M,Martens C,Jacobs P,Velez D,Yim E,Bryke CR,Hsu N,Dai Z,Marquesen MM,Stregevsky E,Kwatemaa N,Theobald N,Long Priel DA,Pittaluga S,Raffeld MA,Calvo KR,Maric I,Desmond R,Holmes KL,Kuhns DB,Balabanian K,Bachelerie F,Porcella SF,Malech HL,Murphy PM

Thu Feb 12 00:00:00 UTC 2015

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

Blood

Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D

Thu Jun 18 00:00:00 UTC 2015

A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.

Blood

Belay E,Miller CP,Kortum AN,Torok-Storb B,Blau CA,Emery DW

Thu Feb 05 00:00:00 UTC 2015

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

Blood

Maude SL,Dolai S,Delgado-Martin C,Vincent T,Robbins A,Selvanathan A,Ryan T,Hall J,Wood AC,Tasian SK,Hunger SP,Loh ML,Mullighan CG,Wood BL,Hermiston ML,Grupp SA,Lock RB,Teachey DT

Thu Mar 12 00:00:00 UTC 2015

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Blood

Kinkel SA,Galeev R,Flensburg C,Keniry A,Breslin K,Gilan O,Lee S,Liu J,Chen K,Gearing LJ,Moore DL,Alexander WS,Dawson M,Majewski IJ,Oshlack A,Larsson J,Blewitt ME

Thu Mar 19 00:00:00 UTC 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Blood

Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A,Hollis RP,Kohn DB

Thu Apr 23 00:00:00 UTC 2015

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Blood

Jang IH,Lu YF,Zhao L,Wenzel PL,Kume T,Datta SM,Arora N,Guiu J,Lagha M,Kim PG,Do EK,Kim JH,Schlaeger TM,Zon LI,Bigas A,Burns CE,Daley GQ

Thu Feb 26 00:00:00 UTC 2015

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.

Blood

Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R

Thu Jan 08 00:00:00 UTC 2015

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

Blood

Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML

Thu Oct 01 00:00:00 UTC 2015

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

The Journal of clinical investigation

Matino D,Gargaro M,Santagostino E,Di Minno MN,Castaman G,Morfini M,Rocino A,Mancuso ME,Di Minno G,Coppola A,Talesa VN,Volpi C,Vacca C,Orabona C,Iannitti R,Mazzucconi MG,Santoro C,Tosti A,Chiappalupi S,Sorci G,Tagariello G,Belvini D,Radossi P,Landolfi R,Fuchs D,Boon L,Pirro M,Marchesini E,Grohmann U,Puccetti P,Iorio A,Fallarino F

Thu Oct 01 00:00:00 UTC 2015

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

The Journal of clinical investigation

Meldi K,Qin T,Buchi F,Droin N,Sotzen J,Micol JB,Selimoglu-Buet D,Masala E,Allione B,Gioia D,Poloni A,Lunghi M,Solary E,Abdel-Wahab O,Santini V,Figueroa ME

Fri May 01 00:00:00 UTC 2015

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.

The Journal of clinical investigation

Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP

Mon Mar 02 00:00:00 UTC 2015

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.

The Journal of clinical investigation

Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP

Mon Mar 02 00:00:00 UTC 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

300-19 was used in Cell Culture to demonstrate that autophagy plays an essential role in TLR7 activation of B cells for the induction of systemic lupus erythematosus.

Mon Apr 18 00:00:00 UTC 2016

Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.

Proceedings of the National Academy of Sciences of the United States of America

McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R

Tue Mar 31 00:00:00 UTC 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America

Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X

Tue Dec 29 00:00:00 UTC 2015

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

British journal of haematology

Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J

Sun Nov 01 00:00:00 UTC 2015

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

European journal of immunology

Temizoz B,Kuroda E,Ohata K,Jounai N,Ozasa K,Kobiyama K,Aoshi T,Ishii KJ

Wed Apr 01 00:00:00 UTC 2015

Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy.

Stem cells (Dayton, Ohio)

Baldwin K,Urbinati F,Romero Z,Campo-Fernandez B,Kaufman ML,Cooper AR,Masiuk K,Hollis RP,Kohn DB

Fri May 01 00:00:00 UTC 2015

Molecular signature of erythroblast enucleation in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H

Sat Aug 01 00:00:00 UTC 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 UTC 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 UTC 2015

TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection.

Journal of immunology (Baltimore, Md. : 1950)

Hotz C,Roetzer LC,Huber T,Sailer A,Oberson A,Treinies M,Heidegger S,Herbst T,Endres S,Bourquin C

Sun Nov 01 00:00:00 UTC 2015

Endogenous intracellular cathelicidin enhances TLR9 activation in dendritic cells and macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Nakagawa Y,Gallo RL

Sun Feb 01 00:00:00 UTC 2015

Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.

Journal of immunology (Baltimore, Md. : 1950)

Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH

Thu Oct 15 00:00:00 UTC 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 UTC 2015

PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm.

Scientific reports

Ono R,Kaisho T,Tanaka T

Fri Dec 18 00:00:00 UTC 2015

Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Molecular therapy. Methods & clinical development

Prel A,Caval V,Gayon R,Ravassard P,Duthoit C,Payen E,Maouche-Chretien L,Creneguy A,Nguyen TH,Martin N,Piver E,Sevrain R,Lamouroux L,Leboulch P,Deschaseaux F,Bouillé P,Sensébé L,Pagès JC

Tue Nov 03 00:00:00 UTC 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 UTC 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 UTC 2015

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.

Molecular therapy. Methods & clinical development

Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW

300-19 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.

Mon Jun 08 00:00:00 UTC 2015

Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.

Scientific reports

Uematsu T,Iizasa E,Kobayashi N,Yoshida H,Hara H

Wed Dec 02 00:00:00 UTC 2015

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.

Stem cell reports

Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F

Tue Oct 13 00:00:00 UTC 2015

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Stem cell reports

Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC

Tue Dec 08 00:00:00 UTC 2015

NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.

The Journal of biological chemistry

Stanicka J,Russell EG,Woolley JF,Cotter TG

Fri Apr 10 00:00:00 UTC 2015

Construction of stable packaging cell lines for clinical lentiviral vector production.

Scientific reports

Sanber KS,Knight SB,Stephen SL,Bailey R,Escors D,Minshull J,Santilli G,Thrasher AJ,Collins MK,Takeuchi Y

Thu Mar 12 00:00:00 UTC 2015

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

Stem cell reports

Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH

Tue Oct 13 00:00:00 UTC 2015

TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality.

Scientific reports

Wang J,Li T,Zhou M,Hu Z,Zhou X,Zhou S,Wang N,Huang L,Zhao L,Cao Y,Xiao M,Ma D,Zhou P,Shang Z,Zhou J

Wed Dec 16 00:00:00 UTC 2015

TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality.

Scientific reports

Wang J,Li T,Zhou M,Hu Z,Zhou X,Zhou S,Wang N,Huang L,Zhao L,Cao Y,Xiao M,Ma D,Zhou P,Shang Z,Zhou J

Wed Dec 16 00:00:00 UTC 2015

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 UTC 2014

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Blood

Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE

Thu Aug 07 00:00:00 UTC 2014

MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.

Blood

Liu S,Yin L,Stroopinsky D,Rajabi H,Puissant A,Stegmaier K,Avigan D,Kharbanda S,Kufe D,Stone R

Thu Jan 30 00:00:00 UTC 2014

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.

Blood

Zhang SL,Wang X,Manna S,Zlotoff DA,Bryson JL,Blazar BR,Bhandoola A

Thu Jul 10 00:00:00 UTC 2014

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.

Blood

Yang Z,Augustin J,Chang C,Hu J,Shah K,Chang CW,Townes T,Jiang H

Thu Sep 25 00:00:00 UTC 2014

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

Blood

Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE

Thu Oct 02 00:00:00 UTC 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 UTC 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 UTC 2014

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

The Journal of clinical investigation

Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR

Fri Aug 01 00:00:00 UTC 2014

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.

The Journal of experimental medicine

Verma R,Su S,McCrann DJ,Green JM,Leu K,Young PR,Schatz PJ,Silva JC,Stokes MP,Wojchowski DM

Mon Aug 25 00:00:00 UTC 2014

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

The Journal of experimental medicine

Ghosh HS,Ceribelli M,Matos I,Lazarovici A,Bussemaker HJ,Lasorella A,Hiebert SW,Liu K,Staudt LM,Reizis B

Mon Jul 28 00:00:00 UTC 2014

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

The Journal of experimental medicine

Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE

Mon Apr 07 00:00:00 UTC 2014

Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.

Proceedings of the National Academy of Sciences of the United States of America

Zarin P,Wong GW,Mohtashami M,Wiest DL,Zúñiga-Pflücker JC

Tue Apr 15 00:00:00 UTC 2014

Quantitative and stoichiometric analysis of the microRNA content of exosomes.

Proceedings of the National Academy of Sciences of the United States of America

Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M

Tue Oct 14 00:00:00 UTC 2014

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.

Proceedings of the National Academy of Sciences of the United States of America

Kobiyama K,Aoshi T,Narita H,Kuroda E,Hayashi M,Tetsutani K,Koyama S,Mochizuki S,Sakurai K,Katakai Y,Yasutomi Y,Saijo S,Iwakura Y,Akira S,Coban C,Ishii KJ

Tue Feb 25 00:00:00 UTC 2014

The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.

Cell death and differentiation

Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW

Wed Jan 01 00:00:00 UTC 2014

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.

Molecular therapy. Nucleic acids

Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U

Tue Oct 07 00:00:00 UTC 2014

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

Blood cancer journal

Askmyr M,Ågerstam H,Lilljebjörn H,Hansen N,Karlsson C,von Palffy S,Landberg N,Högberg C,Lassen C,Rissler M,Richter J,Ehinger M,Järås M,Fioretos T

Fri Dec 12 00:00:00 UTC 2014

Conversion of human fibroblasts into monocyte-like progenitor cells.

Stem cells (Dayton, Ohio)

Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI

Sat Nov 01 00:00:00 UTC 2014

Conversion of human fibroblasts into monocyte-like progenitor cells.

Stem cells (Dayton, Ohio)

Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI

Sat Nov 01 00:00:00 UTC 2014

Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.

Stem cells (Dayton, Ohio)

Fernandez I,Ooi TP,Roy K

Wed Jan 01 00:00:00 UTC 2014

Engineering the human thymic microenvironment to support thymopoiesis in vivo.

Stem cells (Dayton, Ohio)

Chung B,Montel-Hagen A,Ge S,Blumberg G,Kim K,Klein S,Zhu Y,Parekh C,Balamurugan A,Yang OO,Crooks GM

Mon Sep 01 00:00:00 UTC 2014

EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.

Stem cells (Dayton, Ohio)

Zheng WW,Dong XM,Yin RH,Xu FF,Ning HM,Zhang MJ,Xu CW,Yang Y,Ding YL,Wang ZD,Zhao WB,Tang LJ,Chen H,Wang XH,Zhan YQ,Yu M,Ge CH,Li CY,Yang XM

Fri Aug 01 00:00:00 UTC 2014

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M

Fri Aug 15 00:00:00 UTC 2014

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.

Journal of immunology (Baltimore, Md. : 1950)

Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC

Mon Dec 01 00:00:00 UTC 2014

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.

Journal of immunology (Baltimore, Md. : 1950)

Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC

Mon Dec 01 00:00:00 UTC 2014

Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S

Fri Aug 15 00:00:00 UTC 2014

3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.

The Journal of biological chemistry

Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H

Fri Mar 21 00:00:00 UTC 2014

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.

Cell

King B,Trimarchi T,Reavie L,Xu L,Mullenders J,Ntziachristos P,Aranda-Orgilles B,Perez-Garcia A,Shi J,Vakoc C,Sandy P,Shen SS,Ferrando A,Aifantis I

Thu Jun 20 00:00:00 UTC 2013

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Blood

Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H

Thu Apr 25 00:00:00 UTC 2013

Genomic impact of transient low-dose decitabine treatment on primary AML cells.

Blood

Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ

Thu Feb 28 00:00:00 UTC 2013

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Blood

Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS

Thu Apr 04 00:00:00 UTC 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood

Kauskot A,Vandenbriele C,Louwette S,Gijsbers R,Tousseyn T,Freson K,Verhamme P,Hoylaerts MF

Thu Jun 27 00:00:00 UTC 2013

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.

Blood

Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T

Thu May 16 00:00:00 UTC 2013

Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.

Blood

Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL

Thu Apr 04 00:00:00 UTC 2013

β-globin gene transfer to human bone marrow for sickle cell disease.

The Journal of clinical investigation

Romero Z,Urbinati F,Geiger S,Cooper AR,Wherley J,Kaufman ML,Hollis RP,de Assin RR,Senadheera S,Sahagian A,Jin X,Gellis A,Wang X,Gjertson D,Deoliveira S,Kempert P,Shupien S,Abdel-Azim H,Walters MC,Meiselman HJ,Wenby RB,Gruber T,Marder V,Coates TD,Kohn DB

Mon Jul 01 00:00:00 UTC 2013

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

The Journal of clinical investigation

Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN

Thu Aug 01 00:00:00 UTC 2013

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

The Journal of experimental medicine

Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I

Mon Feb 11 00:00:00 UTC 2013

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.

The Journal of experimental medicine

Singh SK,Williams CA,Klarmann K,Burkett SS,Keller JR,Oberdoerffer P

Mon May 06 00:00:00 UTC 2013

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.

Molecular therapy : the journal of the American Society of Gene Therapy

Scaramuzza S,Biasco L,Ripamonti A,Castiello MC,Loperfido M,Draghici E,Hernandez RJ,Benedicenti F,Radrizzani M,Salomoni M,Ranzani M,Bartholomae CC,Vicenzi E,Finocchi A,Bredius R,Bosticardo M,Schmidt M,von Kalle C,Montini E,Biffi A,Roncarolo MG,Naldini L,Villa A,Aiuti A

Tue Jan 01 00:00:00 UTC 2013

Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ye Y,Yan S,Jiang G,Zhou L,Xie H,Xie X,Yu X,Ding Y,Tian J,Dai Y,Zheng S

Fri Mar 01 00:00:00 UTC 2013

Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ye Y,Yan S,Jiang G,Zhou L,Xie H,Xie X,Yu X,Ding Y,Tian J,Dai Y,Zheng S

Fri Mar 01 00:00:00 UTC 2013

Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.

Journal of immunology (Baltimore, Md. : 1950)

Yamazaki C,Sugiyama M,Ohta T,Hemmi H,Hamada E,Sasaki I,Fukuda Y,Yano T,Nobuoka M,Hirashima T,Iizuka A,Sato K,Tanaka T,Hoshino K,Kaisho T

Sat Jun 15 00:00:00 UTC 2013

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y

Sat Jun 15 00:00:00 UTC 2013

Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.

Journal of immunology (Baltimore, Md. : 1950)

Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N

Sun Sep 15 00:00:00 UTC 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 UTC 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 UTC 2013

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Cell

Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA

Fri Jun 08 00:00:00 UTC 2012

Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.

Nature methods

Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM

Mon Oct 01 00:00:00 UTC 2012

RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.

Blood

Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J

Thu Jun 28 00:00:00 UTC 2012

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Blood

Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B

Thu May 31 00:00:00 UTC 2012

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Blood

Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B

Thu May 31 00:00:00 UTC 2012

FANCL ubiquitinates β-catenin and enhances its nuclear function.

Blood

Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC

Thu Jul 12 00:00:00 UTC 2012

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

Blood

Wong GW,Knowles GC,Mak TW,Ferrando AA,Zúñiga-Pflücker JC

Thu Aug 16 00:00:00 UTC 2012

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.

Blood

Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D

Thu Oct 11 00:00:00 UTC 2012

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.

Blood

Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D

Thu Oct 11 00:00:00 UTC 2012

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

The Journal of clinical investigation

Cesana D,Sgualdino J,Rudilosso L,Merella S,Naldini L,Montini E

Tue May 01 00:00:00 UTC 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 UTC 2012

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Proceedings of the National Academy of Sciences of the United States of America

Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I

Tue Oct 23 00:00:00 UTC 2012

Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.

Cytotherapy

Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY

Mon Oct 01 00:00:00 UTC 2012

Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.

Cancer gene therapy

Noyan F,Díez IA,Hapke M,Klein C,Dewey RA

Tue May 01 00:00:00 UTC 2012

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.

Stem cells (Dayton, Ohio)

Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I

Wed Aug 01 00:00:00 UTC 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 UTC 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 UTC 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 UTC 2012

A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.

Journal of immunology (Baltimore, Md. : 1950)

Volpi C,Fallarino F,Bianchi R,Orabona C,De Luca A,Vacca C,Romani L,Gran B,Grohmann U,Puccetti P,Belladonna ML

Sat Sep 01 00:00:00 UTC 2012

Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.

PloS one

Sangeetha VM,Kadekar D,Kale VP,Limaye LS

Mon May 14 00:00:00 UTC 2012

Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.

PloS one

Li XH,Ha CT,Fu D,Xiao M

Thu May 09 00:00:00 UTC 2013

Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.

PloS one

Vatolin S,Khan SN,Reu FJ

Tue Mar 12 00:00:00 UTC 2013

Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.

PloS one

Danova-Alt R,Heider A,Egger D,Cross M,Alt R

Tue Aug 07 00:00:00 UTC 2012

Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.

PloS one

Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H

Wed Dec 12 00:00:00 UTC 2012

Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.

The Journal of biological chemistry

Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z

Fri Aug 24 00:00:00 UTC 2012

Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.

PloS one

Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P

Mon Aug 27 00:00:00 UTC 2012

A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.

PloS one

Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A

Wed May 22 00:00:00 UTC 2013

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC immunology

Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ

Thu Aug 16 00:00:00 UTC 2012

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC immunology

Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ

Thu Aug 16 00:00:00 UTC 2012

Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.

PloS one

Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M

Tue May 21 00:00:00 UTC 2013

Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.

Bone marrow research

Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O

Mon Oct 22 00:00:00 UTC 2012

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.

Cell communication and signaling : CCS

Arora D,Köthe S,van den Eijnden M,Hooft van Huijsduijnen R,Heidel F,Fischer T,Scholl S,Tölle B,Böhmer SA,Lennartsson J,Isken F,Müller-Tidow C,Böhmer FD

Wed Jul 11 00:00:00 UTC 2012

Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.

PloS one

Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A

Wed Jul 24 00:00:00 UTC 2013

Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.

The Journal of biological chemistry

Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y

Fri Nov 23 00:00:00 UTC 2012

Systematic discovery of TLR signaling components delineates viral-sensing circuits.

Cell

Chevrier N,Mertins P,Artyomov MN,Shalek AK,Iannacone M,Ciaccio MF,Gat-Viks I,Tonti E,DeGrace MM,Clauser KR,Garber M,Eisenhaure TM,Yosef N,Robinson J,Sutton A,Andersen MS,Root DE,von Andrian U,Jones RB,Park H,Carr SA,Regev A,Amit I,Hacohen N

Fri Nov 11 00:00:00 UTC 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Cancer cell

Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R

Tue Sep 13 00:00:00 UTC 2011

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.

Cancer cell

Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A,Deblasio A,Hatlen M,Menendez S,Nimer SD

Tue Feb 15 00:00:00 UTC 2011

Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

Cancer cell

Goardon N,Marchi E,Atzberger A,Quek L,Schuh A,Soneji S,Woll P,Mead A,Alford KA,Rout R,Chaudhury S,Gilkes A,Knapper S,Beldjord K,Begum S,Rose S,Geddes N,Griffiths M,Standen G,Sternberg A,Cavenagh J,Hunter H,Bowen D,Killick S,Robinson L,Price A,Macintyre E,Virgo P,Burnett A,Craddock C,Enver T,Jacobsen SE,Porcher C,Vyas P

Tue Jan 18 00:00:00 UTC 2011

Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.

Blood

Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC

Thu Jun 23 00:00:00 UTC 2011

Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.

Blood

Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B

Thu Aug 18 00:00:00 UTC 2011

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Blood

Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ

Thu Sep 01 00:00:00 UTC 2011

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Blood

Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE

Thu Sep 29 00:00:00 UTC 2011

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.

Blood

Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F

Thu Mar 17 00:00:00 UTC 2011

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

Blood

Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ

Thu Feb 03 00:00:00 UTC 2011

Sox6 enhances erythroid differentiation in human erythroid progenitors.

Blood

Cantù C,Ierardi R,Alborelli I,Fugazza C,Cassinelli L,Piconese S,Bosè F,Ottolenghi S,Ferrari G,Ronchi A

Thu Mar 31 00:00:00 UTC 2011

Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.

Blood

Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P

Thu Apr 14 00:00:00 UTC 2011

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Blood

Montes R,Ayllón V,Gutierrez-Aranda I,Prat I,Hernández-Lamas MC,Ponce L,Bresolin S,Te Kronnie G,Greaves M,Bueno C,Menendez P

Thu May 05 00:00:00 UTC 2011

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood

Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ

Thu Mar 17 00:00:00 UTC 2011

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Blood

Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R

Thu Apr 21 00:00:00 UTC 2011

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Blood

Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C

Thu Mar 17 00:00:00 UTC 2011

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.

Blood

Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II

Thu Apr 07 00:00:00 UTC 2011

Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.

The Journal of experimental medicine

Stock A,Booth S,Cerundolo V

Mon Apr 11 00:00:00 UTC 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

Tue Mar 01 00:00:00 UTC 2011

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature protocols

Choi KD,Vodyanik M,Slukvin II

Tue Mar 01 00:00:00 UTC 2011

Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Feng N,Vegh P,Rothenberg EV,Yui MA

Sat Jan 15 00:00:00 UTC 2011

The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells.

Allergy, asthma & immunology research

Mo JH,Chung YJ,Hayashi T,Lee J,Raz E

Fri Jul 01 00:00:00 UTC 2011

Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.

Blood cancer journal

Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT

Tue Feb 01 00:00:00 UTC 2011

Efficient feeder-free episomal reprogramming with small molecules.

PloS one

Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y

Tue Mar 01 00:00:00 UTC 2011

Comparative study of hematopoietic differentiation between human embryonic stem cell lines.

PloS one

Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A

Fri Oct 21 00:00:00 UTC 2011

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.

The Journal of biological chemistry

Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M

Fri Feb 11 00:00:00 UTC 2011

Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.

PloS one

Nishino T,Wang C,Mochizuki-Kashio M,Osawa M,Nakauchi H,Iwama A

Mon Jan 30 00:00:00 UTC 2012

Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.

The Journal of biological chemistry

Sarma NJ,Yaseen NR

Fri Nov 11 00:00:00 UTC 2011

Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.

PloS one

Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X

Tue Feb 14 00:00:00 UTC 2012

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

The Journal of biological chemistry

Arora D,Stopp S,Böhmer SA,Schons J,Godfrey R,Masson K,Razumovskaya E,Rönnstrand L,Tänzer S,Bauer R,Böhmer FD,Müller JP

Fri Apr 01 00:00:00 UTC 2011

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.

PloS one

Sjeklocha LM,Park CW,Wong PY,Roney MJ,Belcher JD,Kaufman DS,Vercellotti GM,Hebbel RP,Steer CJ

Mon May 21 00:00:00 UTC 2012

Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.

PloS one

Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P

Fri Feb 11 00:00:00 UTC 2011

Generation of bivalent chromatin domains during cell fate decisions.

Epigenetics & chromatin

De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR

Mon Jun 06 00:00:00 UTC 2011

Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.

PloS one

Mack AA,Kroboth S,Rajesh D,Wang WB

Mon Apr 02 00:00:00 UTC 2012

Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

Immunity

Hughes T,Becknell B,Freud AG,McClory S,Briercheck E,Yu J,Mao C,Giovenzana C,Nuovo G,Wei L,Zhang X,Gavrilin MA,Wewers MD,Caligiuri MA

Fri Jun 25 00:00:00 UTC 2010

W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.

Blood

Jansson L,Larsson J

Thu Jan 07 00:00:00 UTC 2010

Iron control of erythroid development by a novel aconitase-associated regulatory pathway.

Blood

Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN

Thu Jul 08 00:00:00 UTC 2010

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.

Blood

Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD

Thu Oct 14 00:00:00 UTC 2010

Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.

Blood

Grassinger J,Haylock DN,Williams B,Olsen GH,Nilsson SK

Thu Oct 28 00:00:00 UTC 2010

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

Blood

Agerstam H,Järås M,Andersson A,Johnels P,Hansen N,Lassen C,Rissler M,Gisselsson D,Olofsson T,Richter J,Fan X,Ehinger M,Fioretos T

Thu Sep 23 00:00:00 UTC 2010

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.

Blood

Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H

Thu Dec 02 00:00:00 UTC 2010

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.

The Journal of experimental medicine

Takayama N,Nishimura S,Nakamura S,Shimizu T,Ohnishi R,Endo H,Yamaguchi T,Otsu M,Nishimura K,Nakanishi M,Sawaguchi A,Nagai R,Takahashi K,Yamanaka S,Nakauchi H,Eto K

Mon Dec 20 00:00:00 UTC 2010

MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.

The Journal of experimental medicine

Irla M,Küpfer N,Suter T,Lissilaa R,Benkhoucha M,Skupsky J,Lalive PH,Fontana A,Reith W,Hugues S

Mon Aug 30 00:00:00 UTC 2010

Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.

The Journal of experimental medicine

Buono M,Visigalli I,Bergamasco R,Biffi A,Cosma MP

Mon Aug 02 00:00:00 UTC 2010

Mouse mesenchymal stem cells can support human hematopoiesis both in vitro and in vivo: the crucial role of neural cell adhesion molecule.

Haematologica

Wang X,Hisha H,Mizokami T,Cui W,Cui Y,Shi A,Song C,Okazaki S,Li Q,Feng W,Kato J,Ikehara S

300-19 was used in Cell Culture to investigate the role of MSC surface molecules in the regulation of haematopoiesis.

Tue Jun 01 00:00:00 UTC 2010

Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.

Stem cells (Dayton, Ohio)

Miyata Y,Liu Y,Jankovic V,Sashida G,Lee JM,Shieh JH,Naoe T,Moore M,Nimer SD

Mon Feb 01 00:00:00 UTC 2010

The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development.

Stem cells (Dayton, Ohio)

Szatmari I,Iacovino M,Kyba M

Wed Sep 01 00:00:00 UTC 2010

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Thu Jul 15 00:00:00 UTC 2010

Fine-scale staging of T cell lineage commitment in adult mouse thymus.

Journal of immunology (Baltimore, Md. : 1950)

Yui MA,Feng N,Rothenberg EV

Thu Jul 01 00:00:00 UTC 2010

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice.

Journal of immunology (Baltimore, Md. : 1950)

Reboulet RA,Hennies CM,Garcia Z,Nierkens S,Janssen EM

Wed Sep 15 00:00:00 UTC 2010

miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H

Sat May 01 00:00:00 UTC 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 UTC 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 UTC 2010

Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.

Journal of immunology (Baltimore, Md. : 1950)

van de Laar L,Buitenhuis M,Wensveen FM,Janssen HL,Coffer PJ,Woltman AM

Tue Jun 15 00:00:00 UTC 2010

Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Gwin K,Frank E,Bossou A,Medina KL

Wed Dec 01 00:00:00 UTC 2010

Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.

PloS one

V M S,Kale VP,Limaye LS

Tue Aug 17 00:00:00 UTC 2010

Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.

Nature protocols

Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC

Thu Apr 01 00:00:00 UTC 2010

In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.

PloS one

Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR

Fri Aug 27 00:00:00 UTC 2010

Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

The Journal of biological chemistry

Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ

Fri Jul 02 00:00:00 UTC 2010

Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.

BMC systems biology

Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A

Wed Jun 16 00:00:00 UTC 2010

Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.

BMC immunology

Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø

Fri Jul 09 00:00:00 UTC 2010

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

Immunity

Lauritsen JP,Wong GW,Lee SY,Lefebvre JM,Ciofani M,Rhodes M,Kappes DJ,Zúñiga-Pflücker JC,Wiest DL

Fri Oct 16 00:00:00 UTC 2009

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

Nature immunology

Ilarregui JM,Croci DO,Bianco GA,Toscano MA,Salatino M,Vermeulen ME,Geffner JR,Rabinovich GA

Tue Sep 01 00:00:00 UTC 2009

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Blood

Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B

Thu Nov 05 00:00:00 UTC 2009

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Blood

Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD

Thu Oct 01 00:00:00 UTC 2009

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.

Blood

Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS

Thu Jun 11 00:00:00 UTC 2009

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.

Blood

Nordigården A,Kraft M,Eliasson P,Labi V,Lam EW,Villunger A,Jönsson JI

Thu Mar 05 00:00:00 UTC 2009

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.

Blood

Xue X,Huang X,Nodland SE,Mátés L,Ma L,Izsvák Z,Ivics Z,LeBien TW,McIvor RS,Wagner JE,Zhou X

Thu Aug 13 00:00:00 UTC 2009

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.

Blood

Zhou J,Bi C,Janakakumara JV,Liu SC,Chng WJ,Tay KG,Poon LF,Xie Z,Palaniyandi S,Yu H,Glaser KB,Albert DH,Davidsen SK,Chen CS

Thu Apr 23 00:00:00 UTC 2009

Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.

Blood

Yong AS,Keyvanfar K,Hensel N,Eniafe R,Savani BN,Berg M,Lundqvist A,Adams S,Sloand EM,Goldman JM,Childs R,Barrett AJ

Thu Jan 22 00:00:00 UTC 2009

Role for MKL1 in megakaryocytic maturation.

Blood

Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

Thu Mar 19 00:00:00 UTC 2009

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

Blood

Kandilci A,Grosveld GC

Thu Aug 20 00:00:00 UTC 2009

AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.

Blood

Ding Y,Harada Y,Imagawa J,Kimura A,Harada H

Thu Dec 10 00:00:00 UTC 2009

The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration.

Blood

Porcellini S,Alberici L,Gubinelli F,Lupo R,Olgiati C,Rizzardi GP,Bovolenta C

Thu Apr 09 00:00:00 UTC 2009

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Blood

Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC

Thu Jul 30 00:00:00 UTC 2009

Generation of induced pluripotent stem cells from human blood.

Blood

Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ

Thu May 28 00:00:00 UTC 2009

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.

Blood

Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U

Thu Oct 29 00:00:00 UTC 2009

Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.

Blood

McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ

Thu Jul 09 00:00:00 UTC 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

The Journal of clinical investigation

Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M

Wed Apr 01 00:00:00 UTC 2009

Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.

The Journal of experimental medicine

la Sala A,He J,Laricchia-Robbio L,Gorini S,Iwasaki A,Braun M,Yap GS,Sher A,Ozato K,Kelsall B

Mon Jun 08 00:00:00 UTC 2009

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.

The EMBO journal

Schwermann J,Rathinam C,Schubert M,Schumacher S,Noyan F,Koseki H,Kotlyarov A,Klein C,Gaestel M

Wed May 20 00:00:00 UTC 2009

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Modlich U,Navarro S,Zychlinski D,Maetzig T,Knoess S,Brugman MH,Schambach A,Charrier S,Galy A,Thrasher AJ,Bueren J,Baum C

Sun Nov 01 00:00:00 UTC 2009

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.

Stem cells (Dayton, Ohio)

Compte M,Cuesta AM,Sánchez-Martín D,Alonso-Camino V,Vicario JL,Sanz L,Alvarez-Vallina L

Sun Mar 01 00:00:00 UTC 2009

Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.

Stem cells (Dayton, Ohio)

Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS

Sun Nov 01 00:00:00 UTC 2009

A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.

Stem cells (Dayton, Ohio)

Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A

Thu Jan 01 00:00:00 UTC 2009

IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

van Lent AU,Dontje W,Nagasawa M,Siamari R,Bakker AQ,Pouw SM,Maijoor KA,Weijer K,Cornelissen JJ,Blom B,Di Santo JP,Spits H,Legrand N

Tue Dec 15 00:00:00 UTC 2009

Generation of T cells from human embryonic stem cell-derived hematopoietic zones.

Journal of immunology (Baltimore, Md. : 1950)

Timmermans F,Velghe I,Vanwalleghem L,De Smedt M,Van Coppernolle S,Taghon T,Moore HD,Leclercq G,Langerak AW,Kerre T,Plum J,Vandekerckhove B

Mon Jun 01 00:00:00 UTC 2009

The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.

Journal of immunology (Baltimore, Md. : 1950)

Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R

Mon Jun 01 00:00:00 UTC 2009

RasGRP1 is required for human NK cell function.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Tue Dec 15 00:00:00 UTC 2009

Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.

Human gene therapy

Horiuchi Y,Onodera M,Miyagawa Y,Sato B,Onda K,Katagiri YU,Okita H,Okada M,Otsu M,Kume A,Okuyama T,Fujimoto J,Kuratsuji T,Kiyokawa N

Wed Jul 01 00:00:00 UTC 2009

FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.

The Journal of biological chemistry

Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y

Fri Mar 20 00:00:00 UTC 2009

Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.

PloS one

Das H,George JC,Joseph M,Das M,Abdulhameed N,Blitz A,Khan M,Sakthivel R,Mao HQ,Hoit BD,Kuppusamy P,Pompili VJ

Wed Oct 07 00:00:00 UTC 2009

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

PloS one

Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P

Wed Nov 18 00:00:00 UTC 2009

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.

Cell

Cisse B,Caton ML,Lehner M,Maeda T,Scheu S,Locksley R,Holmberg D,Zweier C,den Hollander NS,Kant SG,Holter W,Rauch A,Zhuang Y,Reizis B

Fri Oct 03 00:00:00 UTC 2008

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Blood

Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T

Fri Feb 15 00:00:00 UTC 2008

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.

Clinical cancer research : an official journal of the American Association for Cancer Research

Su Z,Frye C,Bae KM,Kelley V,Vieweg J

Wed Oct 01 00:00:00 UTC 2008

CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.

Proceedings of the National Academy of Sciences of the United States of America

Kim-Saijo M,Janssen EM,Sugie K

Tue Dec 09 00:00:00 UTC 2008

Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia.

Stem cells (Dayton, Ohio)

Moshaver B,van Rhenen A,Kelder A,van der Pol M,Terwijn M,Bachas C,Westra AH,Ossenkoppele GJ,Zweegman S,Schuurhuis GJ

Mon Dec 01 00:00:00 UTC 2008

Ikaros regulates Notch target gene expression in developing thymocytes.

Journal of immunology (Baltimore, Md. : 1950)

Chari S,Winandy S

Sat Nov 01 00:00:00 UTC 2008

Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions.

PloS one

Hatterer E,Touret M,Belin MF,Honnorat J,Nataf S

Thu Oct 02 00:00:00 UTC 2008

Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?

Blood

Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC

Wed Dec 15 00:00:00 UTC 2004

Induction of potent antitumor immunity by in situ targeting of intratumoral DCs.

The Journal of clinical investigation

Furumoto K,Soares L,Engleman EG,Merad M

Mon Mar 01 00:00:00 UTC 2004

Isolation, growth and identification of colony-forming cells with erythroid, myeloid, dendritic cell and NK-cell potential from human fetal liver.

Biological procedures online

Muench MO,Suskind DL,Bárcena A

300-19 was used in Cell Culture to describe a method for the isolation from human fetal liver of highly purified candidate HSCs and progenitors based on the phenotypes CD38(-)CD34(++) and CD38(+)CD34(++), respectively.

Tue Jun 11 00:00:00 UTC 2002

IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Stober D,Schirmbeck R,Reimann J

300-19 was used in Cell Culture to study how dendritic cells (DCs) are a source of early IFN-gamma generated in response to a cascade of cytokine- and/or cell derived signals that can be positively and negatively regulated.

Sun Jul 15 00:00:00 UTC 2001

Bioinformatics

Protein Aliases: Flt 3 ligand; Flt3 L; Flt3 ligand; Fms-related tyrosine kinase 3 ligand; H-FLT-3-L; M-FLT-3-L; SL cytokine

Human Flt-3 Ligand (FLT3L) Recombinant Protein, PeproTech®

Human Flt-3 Ligand (FLT3L) Protein (300-19-10UG) in Functional

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300-19-10UG

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