Product References
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.
Nature
Arias AA,Neehus AL,Ogishi M,Meynier V,Krebs A,Lazarov T,Lee AM,Arango-Franco CA,Yang R,Orrego J,Corcini Berndt M,Rojas J,Li H,Rinchai D,Erazo-Borrás L,Han JE,Pillay B,Ponsin K,Chaldebas M,Philippot Q,Bohlen J,Rosain J,Le Voyer T,Janotte T,Amarajeeva K,Soudée C,Brollo M,Wiegmann K,Marquant Q,Seeleuthner Y,Lee D,Lainé C,Kloos D,Bailey R,Bastard P,Keating N,Rapaport F,Khan T,Moncada-Vélez M,Carmona MC,Obando C,Alvarez J,Cataño JC,Martínez-Rosado LL,Sanchez JP,Tejada-Giraldo M,L'Honneur AS,Agudelo ML,Perez-Zapata LJ,Arboleda DM,Alzate JF,Cabarcas F,Zuluaga A,Pelham SJ,Ensser A,Schmidt M,Velásquez-Lopera MM,Jouanguy E,Puel A,Krönke M,Ghirardello S,Borghesi A,Pahari S,Boisson B,Pittaluga S,Ma CS,Emile JF,Notarangelo LD,Tangye SG,Marr N,Lachmann N,Salvator H,Schlesinger LS,Zhang P,Glickman MS,Nathan CF,Geissmann F,Abel L,Franco JL,Bustamante J,Casanova JL,Boisson-Dupuis S
300-03 was used in Cell Culture to report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant.
Sun Sep 01 00:00:00 UTC 2024
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Developmental cell
Fowler JL,Zheng SL,Nguyen A,Chen A,Xiong X,Chai T,Chen JY,Karigane D,Banuelos AM,Niizuma K,Kayamori K,Nishimura T,Cromer MK,Gonzalez-Perez D,Mason C,Liu DD,Yilmaz L,Miquerol L,Porteus MH,Luca VC,Majeti R,Nakauchi H,Red-Horse K,Weissman IL,Ang LT,Loh KM
300-03 was used in In vitro experiments to non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate hematopoietic stem cells.
Mon May 06 00:00:00 UTC 2024
Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine.
Cell death & disease
Tambe M,Unterberger S,Kriegbaum MC,Vänttinen I,Olgac EJ,Vähä-Koskela M,Kontro M,Wennerberg K,Heckman CA
300-03 was used in Cell Culture to identify a new vulnerability in acquired venetoclax-resistant AML cells and identify PARP inhibition as a potential therapeutic approach to overcome acquired venetoclax resistance in AML.
Wed Oct 16 00:00:00 UTC 2024
Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Cell reports. Medicine
Albanese M,Chen HR,Gapp M,Muenchhoff M,Yang HH,Peterhoff D,Hoffmann K,Xiao Q,Ruhle A,Ambiel I,Schneider S,Mejías-Pérez E,Stern M,Wratil PR,Hofmann K,Amann L,Jocham L,Fuchs T,Ulivi AF,Besson-Girard S,Weidlich S,Schneider J,Spinner CD,Sutter K,Dittmer U,Humpe A,Baumeister P,Wieser A,Rothenfusser S,Bogner J,Roider J,Knolle P,Hengel H,Wagner R,Laketa V,Fackler OT,Keppler OT
300-03 was used in Cell Culture to report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer.
Tue Apr 16 00:00:00 UTC 2024
Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth.
iScience
Xie X,Gou F,Zheng Z,Zhang Y,Zhang Y,Dong F,Cheng T,Cheng H
300-03 was used in Cell Culture to elucidate the dynamics of fetal hematopoiesis in preparation for birth, offering valuable insights into the pathological processes underlying leukemia.
Fri Aug 16 00:00:00 UTC 2024
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design.
iScience
Li YR,Ochoa CJ,Zhu Y,Kramer A,Wilson M,Fang Y,Chen Y,Singh T,Di Bernardo G,Zhu E,Lee D,Moatamed NA,Bando J,Zhou JJ,Memarzadeh S,Yang L
300-03 was used in Cell Culture to we conducted a comprehensive analysis of primary tumor cells and their microenvironment from 16 chemonaive and 10 recurrent ovarian cancer (OC) patient samples.
Fri Oct 20 00:00:00 UTC 2023
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Cell stem cell
Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X
300-03 was used in Cell Culture to show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.
Thu Jan 05 00:00:00 UTC 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Molecular psychiatry
Albornoz EA,Amarilla AA,Modhiran N,Parker S,Li XX,Wijesundara DK,Aguado J,Zamora AP,McMillan CLD,Liang B,Peng NYG,Sng JDJ,Saima FT,Fung JN,Lee JD,Paramitha D,Parry R,Avumegah MS,Isaacs A,Lo MW,Miranda-Chacon Z,Bradshaw D,Salinas-Rebolledo C,Rajapakse NW,Wolvetang EJ,Munro TP,Rojas-Fernandez A,Young PR,Stacey KJ,Khromykh AA,Chappell KJ,Watterson D,Woodruff TM
300-03 was used in Cell Culture to support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson's disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.
Sat Jul 01 00:00:00 UTC 2023
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
300-03 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 UTC 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
300-03 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 UTC 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
300-03 was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 UTC 2023
Functional characterization of Alzheimer's disease genetic variants in microglia.
Nature genetics
Yang X,Wen J,Yang H,Jones IR,Zhu X,Liu W,Li B,Clelland CD,Luo W,Wong MY,Ren X,Cui X,Song M,Liu H,Chen C,Eng N,Ravichandran M,Sun Y,Lee D,Van Buren E,Jiang MZ,Chan CSY,Ye CJ,Perera RM,Gan L,Li Y,Shen Y
300-03 was used in In vitro experiments to show that AD variants exhibit allelic imbalance on target gene expression.
Sun Oct 01 00:00:00 UTC 2023
Nocardia rubra cell-wall skeleton activates an immune response in cervical tissue via stimulating FPR3 to enhance dendritic cell-mediated Th1 differentiation.
Frontiers in immunology
Guo Q,Chen W,Sun J,Zhao C,Bai X,Zhang Y,Liu K,Zhang L,Shao S
300-03 was used in Tissue/organ culture to indicate that Nr-CWS may target FPR3 on the surface of DC cells and activate a Th1-type immune response.
Mon Mar 27 00:00:00 UTC 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
300-03 was used in Cell Culture to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 UTC 2022
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
300-03 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 UTC 2022
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
Leukemia
Stavast CJ,van Zuijen I,Karkoulia E,Özçelik A,van Hoven-Beijen A,Leon LG,Voerman JSA,Janssen GMC,van Veelen PA,Burocziova M,Brouwer RWW,van IJcken WFJ,Maas A,Bindels EM,van der Velden VHJ,Schliehe C,Katsikis PD,Alberich-Jorda M,Erkeland SJ
300-03 was used in Cell Culture to investigate miRNA-139 in acute myeloid leukemia.
Tue Mar 01 00:00:00 UTC 2022
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
300-03 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 UTC 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
300-03 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 UTC 2022
Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants.
Genes & diseases
Hu C,Shen M,Han X,Chen Q,Li L,Chen S,Zhang J,Gao F,Wang W,Wang Y,Li T,Li S,Huang J,Wang J,Zhu J,Chen D,Wu Q,Tao K,Pang D,Jin A
Sat Jan 01 00:00:00 UTC 2022
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Immunology
Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O
Sun May 01 00:00:00 UTC 2022
Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages.
Journal of leukocyte biology
An L,Michaeli J,Pallavi P,Breedijk A,Xu X,Dietrich N,Sigl M,Keese M,Nitschke K,Jarczyk J,Nuhn P,Krämer BK,Yard BA,Leipe J
Thu Sep 01 00:00:00 UTC 2022
Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.
Frontiers in oncology
Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM
300-03 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.
Sat Jul 16 00:00:00 UTC 2022
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
300-03 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 UTC 2022
Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.
Journal of clinical laboratory analysis
Xu W,Li S,Li M,Zhou H,Yang X
300-03 was used in Sample Preparation (FC/FACS) to investigate myeloid-derived suppressor cells in immunotherapy of cancer.
Sat Jan 01 00:00:00 UTC 2022
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.
JCI insight
Tsao LC,Crosby EJ,Trotter TN,Wei J,Wang T,Yang X,Summers AN,Lei G,Rabiola CA,Chodosh LA,Muller WJ,Lyerly HK,Hartman ZC
300-03 was used in Sample Preparation (FC/FACS) to identify classical complement activation as a significant antitumor MOA for T+P therapy that may be functionally enhanced to potentially augment clinical therapeutic efficacy.
Tue Mar 22 00:00:00 UTC 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.
Frontiers in immunology
Ng L,Wang X,Yang C,Su C,Li M,Cheung AKL
300-03 was used in Cell Culture to conclude that regulating the intracellular trafficking/processing of α-syn by DCs can be a potential approach to control the progression of PD, in which Celastrol is a potential candidate to accomplish this.
Mon May 02 00:00:00 UTC 2022
Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs.
Frontiers in immunology
Dorna J,Kaufmann A,Bockmann V,Raifer H,West J,Matrosovich M,Bauer S
300-03 was used in In vitro experiments to study the infection of total human peripheral blood mononuclear cells (PBMCs) and subpopulations of human PBMCs with well characterized recombinant influenza A viruses differing by the hemagglutinin and the neuraminidase (NA) but sharing all other viral proteins.
Fri Apr 08 00:00:00 UTC 2022
Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.
Cancer medicine
Zhang S,Wang H,Liu Y,Tao T,Zeng Z,Zhou Y,Wang M
300-03 was used in Cell Culture to suggest that Nr-CWS can promote apoptosis of cervical carcinoma cells by enhancing the antitumor effect of dendritic cells and macrophages.
Tue Mar 01 00:00:00 UTC 2022
Delivering an mRNA vaccine using a lymphatic drug delivery device improves humoral and cellular immunity against SARS-CoV-2.
Journal of molecular cell biology
Chen R,Xie H,Khorsandzadeh S,Smith M,Shaabani N,Hu Q,Lyu X,Wang H,Lim WL,Sun H,Ji H,Cooley B,Ross R,Francis DM
300-03 was used in In vitro experiments to report the synthesis of a novel messenger ribonucleic acid encoding the spike protein in a lipid nanoparticle formulation (STI-7264) that generates robust humoral and cellular immunity following immunization of C57Bl6 mice.
Fri Aug 26 00:00:00 UTC 2022
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
Cell reports
Alam MM,Yang D,Li XQ,Liu J,Back TC,Trivett A,Karim B,Barbut D,Zasloff M,Oppenheim JJ
300-03 was used in Cell Culture to show that αS is a critical mediator of inflammatory and immune responses.
Tue Jan 11 00:00:00 UTC 2022
Blocking LAIR1 signaling in immune cells inhibits tumor development.
Frontiers in immunology
Xie J,Gui X,Deng M,Chen H,Chen Y,Liu X,Ku Z,Tan L,Huang R,He Y,Zhang B,Lewis C,Chen K,Xu L,Xu J,Huang T,Liao XC,Zhang N,An Z,Zhang CC
300-03 was used in In vitro experiments to suggest that blocking LAIR1 signaling with antagonist antibodies represents a new attractive anticancer strategy.
Tue Oct 11 00:00:00 UTC 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
300-03 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 UTC 2022
Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.
Cell reports
Chang Y,Syahirah R,Wang X,Jin G,Torregrosa-Allen S,Elzey BD,Hummel SN,Wang T,Li C,Lian X,Deng Q,Broxmeyer HE,Bao X
300-03 was used in Cell Culture to establish a robust platform for massive production of CAR neutrophils, paving the way to myeloid cell-based therapeutic strategies that would boost current cancer-treatment approaches.
Tue Jul 19 00:00:00 UTC 2022
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells.
Cell reports. Medicine
Li H,Liu Z,Liu L,Zhang H,Han C,Girard L,Park H,Zhang A,Dong C,Ye J,Rayford A,Peyton M,Li X,Avila K,Cao X,Hu S,Alam MM,Akbay EA,Solis LM,Behrens C,Hernandez-Ruiz S,Lu W,Wistuba I,Heymach JV,Chisamore M,Micklem D,Gabra H,Gausdal G,Lorens JB,Li B,Fu YX,Minna JD,Brekken RA
300-03 was used in Cell Culture to explore why mutations in STK11/LKB1 in non-small lung cancer are associated with poor patient responses to immune checkpoint blockade and introduction of Stk11/Lkb1 mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 loss resulted in an ICB refractory syngeneic KPL tumour.
Tue Mar 15 00:00:00 UTC 2022
Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers.
iScience
Li YR,Zeng S,Dunn ZS,Zhou Y,Li Z,Yu J,Wang YC,Ku J,Cook N,Kramer A,Yang L
300-03 was used in In vitro experiments to report the successful generation of third-party HSC-engineered human iNKT (3rdHSC-iNKT) cells using a method combining HSC gene engineering and in vitro HSC differentiation.
Fri Sep 16 00:00:00 UTC 2022
The interferon landscape along the respiratory tract impacts the severity of COVID-19.
Cell
Sposito B,Broggi A,Pandolfi L,Crotta S,Clementi N,Ferrarese R,Sisti S,Criscuolo E,Spreafico R,Long JM,Ambrosi A,Liu E,Frangipane V,Saracino L,Bozzini S,Marongiu L,Facchini FA,Bottazzi A,Fossali T,Colombo R,Clementi M,Tagliabue E,Chou J,Pontiroli AE,Meloni F,Wack A,Mancini N,Zanoni I
Thu Sep 16 00:00:00 UTC 2021
Macrophage and neutrophil death programs differentially confer resistance to tuberculosis.
Immunity
Stutz MD,Allison CC,Ojaimi S,Preston SP,Doerflinger M,Arandjelovic P,Whitehead L,Bader SM,Batey D,Asselin-Labat ML,Herold MJ,Strasser A,West NP,Pellegrini M
Tue Aug 10 00:00:00 UTC 2021
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Immunity
Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C
Tue Apr 13 00:00:00 UTC 2021
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cancer cell
Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG
300-03 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.
Mon Jul 12 00:00:00 UTC 2021
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell host & microbe
Bou-Nader C,Muecksch F,Brown JB,Gordon JM,York A,Peng C,Ghirlando R,Summers MF,Bieniasz PD,Zhang J
Wed Sep 08 00:00:00 UTC 2021
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection.
Nature immunology
Munnur D,Teo Q,Eggermont D,Lee HHY,Thery F,Ho J,van Leur SW,Ng WWS,Siu LYL,Beling A,Ploegh H,Pinto-Fernandez A,Damianou A,Kessler B,Impens F,Mok CKP,Sanyal S
Mon Nov 01 00:00:00 UTC 2021
Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.
Blood
Mosca M,Hermange G,Tisserand A,Noble R,Marzac C,Marty C,Le Sueur C,Campario H,Vertenoeil G,El-Khoury M,Catelain C,Rameau P,Gella C,Lenglet J,Casadevall N,Favier R,Solary E,Cassinat B,Kiladjian JJ,Constantinescu SN,Pasquier F,Hochberg ME,Raslova H,Villeval JL,Girodon F,Vainchenker W,Cournède PH,Plo I
Thu Dec 02 00:00:00 UTC 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
300-03 was used in Cell Culture to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 UTC 2021
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.
Cell stem cell
Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S
Thu Mar 04 00:00:00 UTC 2021
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Cell stem cell
Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE
Thu May 06 00:00:00 UTC 2021
Human skin is colonized by T cells that recognize CD1a independently of lipid.
The Journal of clinical investigation
Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB
Mon Jan 04 00:00:00 UTC 2021
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis.
The Journal of experimental medicine
Rosu A,El Hachem N,Rapino F,Rouault-Pierre K,Jorssen J,Somja J,Ramery E,Thiry M,Nguyen L,Jacquemyn M,Daelemans D,Adams CM,Bonnet D,Chariot A,Close P,Bureau F,Desmet CJ
Mon Mar 01 00:00:00 UTC 2021
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
The Journal of experimental medicine
Lu X,Hosono Y,Nagae M,Ishizuka S,Ishikawa E,Motooka D,Ozaki Y,Sax N,Maeda Y,Kato Y,Morita T,Shinnakasu R,Inoue T,Onodera T,Matsumura T,Shinkai M,Sato T,Nakamura S,Mori S,Kanda T,Nakayama EE,Shioda T,Kurosaki T,Takeda K,Kumanogoh A,Arase H,Nakagami H,Yamashita K,Takahashi Y,Yamasaki S
Mon Dec 06 00:00:00 UTC 2021
The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells.
Cancer immunology research
Paavola KJ,Roda JM,Lin VY,Chen P,O'Hollaren KP,Ventura R,Crawley SC,Li B,Chen HH,Malmersjö S,Sharkov NA,Horner G,Guo W,Kutach AK,Mondal K,Zhang Z,Lichtman JS,Song C,Rivera LB,Liu W,Luo J,Wang Y,Solloway MJ,Allan BB,Kekatpure A,Starck SR,Haldankar R,Fan B,Chu C,Tang J,Molgora M,Colonna M,Kaplan DD,Hsu JY
300-03 was used in In vitro experiments to show that, by blocking this interaction, tumor-associated myeloid cells may acquire a stimulatory phenotype, potentially resulting in increased antitumor T-cell responses.
Mon Nov 01 00:00:00 UTC 2021
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells.
The Journal of infectious diseases
Zheng J,Wang Y,Li K,Meyerholz DK,Allamargot C,Perlman S
Wed Mar 03 00:00:00 UTC 2021
Enhanced Uptake of Processed Bovine β-Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity.
Molecular nutrition & food research
Teodorowicz M,Zenker HE,Ewaz A,Tsallis T,Mauser A,Gensberger-Reigl S,de Jong NW,Hettinga KA,Wichers HJ,van Neerven RJJ,Savelkoul HFJ
Thu Apr 01 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
300-03 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
300-03 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 UTC 2021
Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes.
Molecular therapy oncolytics
Labani-Motlagh A,Naseri S,Wenthe J,Eriksson E,Loskog A
Fri Mar 26 00:00:00 UTC 2021
Mycobacterium leprae induces a tolerogenic profile in monocyte-derived dendritic cells via TLR2 induction of IDO.
Journal of leukocyte biology
Oliveira JAP,Gandini M,Sales JS,Fujimori SK,Barbosa MGM,Frutuoso VS,Moraes MO,Sarno EN,Pessolani MCV,Pinheiro RO
Thu Jul 01 00:00:00 UTC 2021
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Frontiers in oncology
Zhao Y,Zhang Z,Lei W,Wei Y,Ma R,Wen Y,Wei F,Fan J,Xu Y,Chen L,Lyu K,Lin H,Wen W,Sun W
300-03 was used in Cell Culture to study that IL-21 could promote PD-L1-induced Treg generation in a PD-1-dependent manner.
Wed May 26 00:00:00 UTC 2021
ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Nazitto R,Amon LM,Mast FD,Aitchison JD,Aderem A,Johnson JS,Diercks AH
Tue Jun 15 00:00:00 UTC 2021
T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Layton ED,Barman S,Wilburn DB,Yu KKQ,Smith MT,Altman JD,Scriba TJ,Tahiri N,Minnaard AJ,Roederer M,Seder RA,Darrah PA,Seshadri C
Mon Mar 15 00:00:00 UTC 2021
β-Arrestin 2 Regulates Inflammatory Responses against Mycobacterium tuberculosis Infection through ERK1/2 Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Wen Q,Li Y,Han Z,Liu H,Zhang S,Chen Y,He J,Du X,Fu Y,Zhang L,Zhang Z,Huang Y,Zhou X,Zhou C,Hu S,Ma L
Tue Jun 01 00:00:00 UTC 2021
CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Possamaï D,Pagé G,Panès R,Gagnon É,Lapointe R
Thu Jul 01 00:00:00 UTC 2021
Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β.
Journal of immunology (Baltimore, Md. : 1950)
Allaeys I,Ribeiro de Vargas F,Bourgoin SG,Poubelle PE
Thu Apr 15 00:00:00 UTC 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 UTC 2021
Endocytosed nanogold fiducials for improved in-situ cryo-electron tomography tilt-series alignment.
Journal of structural biology
Berger C,Ravelli RBG,López-Iglesias C,Peters PJ
300-03 was used in Cell Culture to describe a method to allow uptake of bovine serum albumin (BSA)-gold fiducials into mammalian cells via endocytosis, which can subsequently be used as fiducials for tilt-series alignment of cryo-focused ion beam (FIB) lamellae.
Mon Mar 01 00:00:00 UTC 2021
Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA).
Cell death & disease
Klaas L,Vier J,Gentle IE,Häcker G,Kirschnek S
Thu Oct 28 00:00:00 UTC 2021
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Nature communications
Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M
Fri May 21 00:00:00 UTC 2021
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration.
Frontiers in immunology
Uetz-von Allmen E,Samson GPB,Purvanov V,Maeda T,Legler DF
300-03 was used in Cell Culture to show that the previously established human neoplastic cell line CAL-1 expresses the human dendritic cell surface antigens CD11c and HLA-DR together with co-stimulatory molecules.
Mon Dec 13 00:00:00 UTC 2021
Biomimetic Anti-PD-1 Peptide-Loaded 2D FePSe3 Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Fang X,Wu X,Li Z,Jiang L,Lo WS,Chen G,Gu Y,Wong WT
Fri Jan 01 00:00:00 UTC 2021
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway.
Nature communications
Alicea-Torres K,Sanseviero E,Gui J,Chen J,Veglia F,Yu Q,Donthireddy L,Kossenkov A,Lin C,Fu S,Mulligan C,Nam B,Masters G,Denstman F,Bennett J,Hockstein N,Rynda-Apple A,Nefedova Y,Fuchs SY,Gabrilovich DI
Fri Mar 19 00:00:00 UTC 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 UTC 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
Wed Jul 21 00:00:00 UTC 2021
Soluble Prokaryotic Overexpression and Purification of Human GM-CSF Using the Protein Disulfide Isomerase b'a' Domain.
International journal of molecular sciences
Nguyen TKO,Vu TL,Nguyen MQ,Ta HKK,Park KS,Kim SH,Kim CJ,Jang YJ,Choe H
300-03 was used in In vitro experiments to examine the solubility of human Granulocyte-macrophage colony-stimulating factor when combined with three N-terminal fusion tags in five E. coli strains at three different expression temperatures.
Mon May 17 00:00:00 UTC 2021
Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.
Cell death & disease
Wanke F,Gutbier S,Rümmelin A,Steinberg M,Hughes LD,Koenen M,Komuczki J,Regan-Komito D,Wagage S,Hesselmann J,Thoma R,Brugger D,Christopeit T,Wang H,Point F,Hallet R,Ghosh S,Rothlin CV,Patsch C,Geering B
Tue May 25 00:00:00 UTC 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
Tue May 18 00:00:00 UTC 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
Tue May 18 00:00:00 UTC 2021
TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion.
Frontiers in immunology
You Y,Stelzl P,Joseph DN,Aldo PB,Maxwell AJ,Dekel N,Liao A,Whirledge S,Mor G
300-03 was used in In vitro experiments to provide a new insight into the complexity of the implantation process and reveal the importance of inflammation for embryo implantation.
Fri Dec 24 00:00:00 UTC 2021
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.
FEBS open bio
Zhang H,Liu P,Zhang Y,Han L,Hu Z,Cai Z,Cai J
Mon Mar 01 00:00:00 UTC 2021
Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer.
International journal of breast cancer
Ghimirey N,Steele C,Czerniecki BJ,Koski GK,Showalter LE
Tue May 04 00:00:00 UTC 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
300-03 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 UTC 2021
Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants.
Communications biology
Cavarelli M,Hua S,Hantour N,Tricot S,Tchitchek N,Gommet C,Hocini H,Chapon C,Dereuddre-Bosquet N,Le Grand R
Mon Jul 12 00:00:00 UTC 2021
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis.
Nature communications
Andres-Ejarque R,Ale HB,Grys K,Tosi I,Solanky S,Ainali C,Catak Z,Sreeneebus H,Saklatvala J,Dand N,de Rinaldis E,Chapman A,Nestle FO,Barnes MR,Warren RB,Reynolds NJ,Griffiths CEM,Barker JN,Smith CH,Di Meglio P
Fri Aug 06 00:00:00 UTC 2021
SARS-CoV-2 Induces Lymphocytopenia by Promoting Inflammation and Decimates Secondary Lymphoid Organs.
Frontiers in immunology
Xiang Q,Feng Z,Diao B,Tu C,Qiao Q,Yang H,Zhang Y,Wang G,Wang H,Wang C,Liu L,Wang C,Liu L,Chen R,Wu Y,Chen Y
300-03 was used in In vitro experiments to demonstrate that SARS-CoV-2 induced lymphocytopenia by promoting systemic inflammation and direct neutralization in human spleen and LNs.
Tue May 25 00:00:00 UTC 2021
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
The Journal of clinical investigation
Zheng J,Meyerholz D,Wong LR,Gelb M,Murakami M,Perlman S
Tue Jun 01 00:00:00 UTC 2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Nature communications
Clement CC,D'Alessandro A,Thangaswamy S,Chalmers S,Furtado R,Spada S,Mondanelli G,Ianni F,Gehrke S,Gargaro M,Manni G,Cara LCL,Runge P,Tsai WL,Karaman S,Arasa J,Fernandez-Rodriguez R,Beck A,Macchiarulo A,Gadina M,Halin C,Fallarino F,Skobe M,Veldhoen M,Moretti S,Formenti S,Demaria S,Soni RK,Galarini R,Sardella R,Lauvau G,Putterman C,Alitalo K,Grohmann U,Santambrogio L
Wed Jul 21 00:00:00 UTC 2021
Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Nature protocols
Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R
300-03 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.
Mon Feb 01 00:00:00 UTC 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Nature communications
Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM
Mon Mar 01 00:00:00 UTC 2021
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Scientific reports
Wang X,Negrou E,Maloney MT,Bondar VV,Andrews SV,Montalban M,Llapashtica C,Maciuca R,Nguyen H,Solanoy H,Arguello A,Przybyla L,Moerke NJ,Huntwork-Rodriguez S,Henry AG
Fri Jun 18 00:00:00 UTC 2021
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
300-03 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 UTC 2021
Ionizing Radiation Curtails Immunosuppressive Effects From Cancer-Associated Fibroblasts on Dendritic Cells.
Frontiers in immunology
Berzaghi R,Tornaas S,Lode K,Hellevik T,Martinez-Zubiaurre I
300-03 was used in Sample Preparation (FC/FACS) to study immunomodulatory functions of cancer-associated fibroblasts (CAFs) during/after radiotherapy by studying the effects of ionizing radiation on CAF-mediated regulation of dendritic cells (DCs) to demonstrate hat CAFs interfere with DC immune functions and unveil that certain radiation regimens may reverse CAF-mediated immunosuppressive effects.
Thu Oct 14 00:00:00 UTC 2021
HIV induces airway basal progenitor cells to adopt an inflammatory phenotype.
Scientific reports
Chung NPY,Khan KMF,Kaner RJ,O'Beirne SL,Crystal RG
Wed Feb 17 00:00:00 UTC 2021
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.
Cell death & disease
Fang S,Wan X,Zou X,Sun S,Hao X,Liang C,Zhang Z,Zhang F,Sun B,Li H,Yu B
Mon Jan 18 00:00:00 UTC 2021
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 UTC 2021
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.
Scientific reports
Yamawaki K,Shiina I,Murata T,Tateyama S,Maekawa Y,Niwa M,Shimonaka M,Okamoto K,Suzuki T,Nishida T,Abe R,Obata Y
Mon Nov 22 00:00:00 UTC 2021
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Nature communications
Wang J,Wang J,Hong W,Zhang L,Song L,Shi Q,Shao Y,Hao G,Fang C,Qiu Y,Yang L,Yang Z,Wang J,Cao J,Yang B,He Q,Weng Q
Wed Oct 27 00:00:00 UTC 2021
Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen.
Scientific reports
Miebach L,Freund E,Horn S,Niessner F,Sagwal SK,von Woedtke T,Emmert S,Weltmann KD,Clemen R,Schmidt A,Gerling T,Bekeschus S
Fri Jan 08 00:00:00 UTC 2021
In vitro expansion of fetal liver hematopoietic stem cells.
Scientific reports
Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V
Fri Jun 04 00:00:00 UTC 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
300-03 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 UTC 2021
The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.
Molecular & cellular proteomics : MCP
Thomé CH,Ferreira GA,Pereira-Martins DA,Augusto Dos Santos G,Almeida-Silveira DR,Weinhäuser I,Antônio de Souza G,Houtsma R,Schuringa JJ,Rego EM,Faça VM
Mon Mar 21 00:00:00 UTC 2022
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.
Nature communications
Mysore V,Cullere X,Mears J,Rosetti F,Okubo K,Liew PX,Zhang F,Madera-Salcedo I,Rosenbauer F,Stone RM,Aster JC,von Andrian UH,Lichtman AH,Raychaudhuri S,Mayadas TN
300-03 was used in Sample Preparation (FC/FACS) to investigate classical dendritic cells and antigen-presenting cells in immunity.
Mon Aug 09 00:00:00 UTC 2021
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.
Nature communications
Mysore V,Cullere X,Mears J,Rosetti F,Okubo K,Liew PX,Zhang F,Madera-Salcedo I,Rosenbauer F,Stone RM,Aster JC,von Andrian UH,Lichtman AH,Raychaudhuri S,Mayadas TN
300-03 was used in Sample Preparation (FC/FACS) to investigate classical dendritic cells and antigen-presenting cells in immunity.
Mon Aug 09 00:00:00 UTC 2021
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.
Translational psychiatry
Sheridan SD,Thanos JM,De Guzman RM,McCrea LT,Horng JE,Fu T,Sellgren CM,Perlis RH,Edlow AG
Fri Mar 19 00:00:00 UTC 2021
Chemotherapy agents stimulate dendritic cells against human colon cancer cells through upregulation of the transporter associated with antigen processing.
Scientific reports
Liang YH,Tsai JH,Cheng YM,Chan KY,Hsu WL,Lee CC,Chen KH,Yeh KH
Tue Apr 27 00:00:00 UTC 2021
Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.
Vaccines
Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y
300-03 was used in Sample Preparation (FC/FACS) to investigate treatment for esophageal squamous cell carcinoma.
Fri Oct 01 00:00:00 UTC 2021
The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein.
Scientific reports
Yusuf B,Mukovozov I,Patel S,Huang YW,Liu GY,Reddy EC,Skrtic M,Glogauer M,Robinson LA
Thu Feb 11 00:00:00 UTC 2021
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Nature communications
Xing J,Zhang A,Du Y,Fang M,Minze LJ,Liu YJ,Li XC,Zhang Z
300-03 was used in Cell Culture to investigate the role of poly(ADP-ribose) polymerase 9 on type I IFN production in dendritic cells.
Tue May 11 00:00:00 UTC 2021
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Nature communications
Xing J,Zhang A,Du Y,Fang M,Minze LJ,Liu YJ,Li XC,Zhang Z
300-03 was used in Cell Culture to investigate the role of poly(ADP-ribose) polymerase 9 on type I IFN production in dendritic cells.
Tue May 11 00:00:00 UTC 2021
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Science immunology
Niyonzima N,Rahman J,Kunz N,West EE,Freiwald T,Desai JV,Merle NS,Gidon A,Sporsheim B,Lionakis MS,Evensen K,Lindberg B,Skagen K,Skjelland M,Singh P,Haug M,Ruseva MM,Kolev M,Bibby J,Marshall O,O'Brien B,Deeks N,Afzali B,Clark RJ,Woodruff TM,Pryor M,Yang ZH,Remaley AT,Mollnes TE,Hewitt SM,Yan B,Kazemian M,Kiss MG,Binder CJ,Halvorsen B,Espevik T,Kemper C
300-03 was used in Sample Preparation (Western Blotting) to suggest that the complosome is a contributor to the biologic processes underlying sterile inflammation and indicate that targeting this system could be beneficial in macrophage-dependent diseases, such as atherosclerosis.
Fri Dec 24 00:00:00 UTC 2021
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
Cell
Li Q,Wu J,Nie J,Zhang L,Hao H,Liu S,Zhao C,Zhang Q,Liu H,Nie L,Qin H,Wang M,Lu Q,Li X,Sun Q,Liu J,Zhang L,Li X,Huang W,Wang Y
Thu Sep 03 00:00:00 UTC 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
Thu Apr 16 00:00:00 UTC 2020
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.
Cell
Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S
Thu Mar 19 00:00:00 UTC 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
Thu Mar 19 00:00:00 UTC 2020
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Immunity
Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H
300-03 was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.
Tue Dec 15 00:00:00 UTC 2020
Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.
Immunity
Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C
Tue Jun 16 00:00:00 UTC 2020
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature genetics
Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC
300-03 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).
Wed Apr 01 00:00:00 UTC 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
Mon Jul 13 00:00:00 UTC 2020
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer discovery
Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A
300-03 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.
Tue Dec 01 00:00:00 UTC 2020
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Nature immunology
Zhou QD,Chi X,Lee MS,Hsieh WY,Mkrtchyan JJ,Feng AC,He C,York AG,Bui VL,Kronenberger EB,Ferrari A,Xiao X,Daly AE,Tarling EJ,Damoiseaux R,Scumpia PO,Smale ST,Williams KJ,Tontonoz P,Bensinger SJ
300-03 was used in Cell Culture to investigate how pathogens escape cholesterol-dependent cytolysins during infection.
Wed Jul 01 00:00:00 UTC 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 UTC 2020
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.
Blood
Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG
Thu Aug 27 00:00:00 UTC 2020
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
The Journal of clinical investigation
Cafri G,Gartner JJ,Zaks T,Hopson K,Levin N,Paria BC,Parkhurst MR,Yossef R,Lowery FJ,Jafferji MS,Prickett TD,Goff SL,McGowan CT,Seitter S,Shindorf ML,Parikh A,Chatani PD,Robbins PF,Rosenberg SA
Mon Nov 02 00:00:00 UTC 2020
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
Nugent AA,Lin K,van Lengerich B,Lianoglou S,Przybyla L,Davis SS,Llapashtica C,Wang J,Kim DJ,Xia D,Lucas A,Baskaran S,Haddick PCG,Lenser M,Earr TK,Shi J,Dugas JC,Andreone BJ,Logan T,Solanoy HO,Chen H,Srivastava A,Poda SB,Sanchez PE,Watts RJ,Sandmann T,Astarita G,Lewcock JW,Monroe KM,Di Paolo G
Wed Mar 04 00:00:00 UTC 2020
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.
The Journal of experimental medicine
Freund EC,Lock JY,Oh J,Maculins T,Delamarre L,Bohlen CJ,Haley B,Murthy A
Mon Jul 06 00:00:00 UTC 2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
EMBO molecular medicine
Wilcz-Villega E,Carter E,Ironside A,Xu R,Mataloni I,Holdsworth J,Jones W,Moreno Béjar R,Uhlik L,Bentham RB,Godinho SA,Dalli J,Grose R,Szabadkai G,Jones L,Hodivala-Dilke K,Bianchi K
Fri Feb 07 00:00:00 UTC 2020
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.
Proceedings of the National Academy of Sciences of the United States of America
Preciado-Llanes L,Aulicino A,Canals R,Moynihan PJ,Zhu X,Jambo N,Nyirenda TS,Kadwala I,Sousa Gerós A,Owen SV,Jambo KC,Kumwenda B,Veerapen N,Besra GS,Gordon MA,Hinton JCD,Napolitani G,Salio M,Simmons A
Tue Aug 25 00:00:00 UTC 2020
Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Anton OM,Peterson ME,Hollander MJ,Dorward DW,Arora G,Traba J,Rajagopalan S,Snapp EL,Garcia KC,Waldmann TA,Long EO
Tue Jan 07 00:00:00 UTC 2020
ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.
Oncogene
Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA
Wed Apr 01 00:00:00 UTC 2020
The transition of M-CSF-derived human macrophages to a growth-promoting phenotype.
Blood advances
Hamidzadeh K,Belew AT,El-Sayed NM,Mosser DM
300-03 was used in Sample Preparation (ELISA) to demonstrate that inflammation induced by Toll-like receptor stimulation is followed by the upregulation of receptors for adenosine and prostaglandin E2, which help terminate macrophage activation and initiate tissue remodeling and angiogenesis.
Tue Nov 10 00:00:00 UTC 2020
Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Thomas R,Shaath H,Naik A,Toor SM,Elkord E,Decock J
300-03 was used in In vitro experiments to investigate the immunogenicity of LDHC using T cells from healthy individuals.
Sun Mar 01 00:00:00 UTC 2020
Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential-dependent NET-formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Reithofer M,Karacs J,Strobl J,Kitzmüller C,Polak D,Seif K,Kamalov M,Becker CFW,Greiner G,Schmetterer K,Stary G,Bohle B,Jahn-Schmid B
Thu Oct 01 00:00:00 UTC 2020
Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Inokuchi S,Mitoma H,Kawano S,Nakano S,Ayano M,Kimoto Y,Akahoshi M,Arinobu Y,Tsukamoto H,Akashi K,Horiuchi T,Niiro H
Wed Apr 15 00:00:00 UTC 2020
Intratumoral Activation of 41BB Costimulatory Signals Enhances CD8 T Cell Expansion and Modulates Tumor-Infiltrating Myeloid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Innamarato P,Asby S,Morse J,Mackay A,Hall M,Kidd S,Nagle L,Sarnaik AA,Pilon-Thomas S
Sun Nov 15 00:00:00 UTC 2020
Activation of Human Vδ2+ γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cooper AJR,Lalor SJ,McLoughlin RM
Sat Aug 15 00:00:00 UTC 2020
T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Current protocols in immunology
Rollins MR,Spartz EJ,Stromnes IM
300-03 was used in Sample Preparation (FC/FACS) to synthesize and expand upon methodologies to generate, isolate, and engineer human T cells with tumor-reactive TCRs for adoptive cell therapy.
Mon Jun 01 00:00:00 UTC 2020
Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction.
Scientific reports
Nzou G,Wicks RT,VanOstrand NR,Mekky GA,Seale SA,El-Taibany A,Wicks EE,Nechtman CM,Marrotte EJ,Makani VS,Murphy SV,Seeds MC,Jackson JD,Atala AJ
Wed Jun 17 00:00:00 UTC 2020
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.
Science immunology
Alshetaiwi H,Pervolarakis N,McIntyre LL,Ma D,Nguyen Q,Rath JA,Nee K,Hernandez G,Evans K,Torosian L,Silva A,Walsh C,Kessenbrock K
300-03 was used in Sample Preparation (FC/FACS) to establish the MDSC-specific gene signature and identify CD84 as a surface marker for improved detection and enrichment of MDSCs in breast cancers.
Fri Feb 21 00:00:00 UTC 2020
Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells.
Scientific reports
Kaur K,Ko MW,Ohanian N,Cook J,Jewett A
Mon Nov 23 00:00:00 UTC 2020
The regulatory role of PGC1α-related coactivator in response to drug-induced liver injury.
FASEB bioAdvances
Buler M,Naessens T,Mattsson J,Morias Y,Söderberg M,Robbins P,Kärrberg L,Svensson TS,Thulin P,Glinghammar B,Scarpulla RC,Andersson U
Sat Aug 01 00:00:00 UTC 2020
A versatile and customizable low-cost 3D-printed open standard for microscopic imaging.
Nature communications
Diederich B,Lachmann R,Carlstedt S,Marsikova B,Wang H,Uwurukundo X,Mosig AS,Heintzmann R
Wed Nov 25 00:00:00 UTC 2020
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection.
Nature communications
Beckwith KS,Beckwith MS,Ullmann S,Sætra RS,Kim H,Marstad A,Åsberg SE,Strand TA,Haug M,Niederweis M,Stenmark HA,Flo TH
Fri May 08 00:00:00 UTC 2020
Distinct macrophage phenotypes skewed by local granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis.
Clinical & translational immunology
Jiemy WF,van Sleen Y,van der Geest KS,Ten Berge HA,Abdulahad WH,Sandovici M,Boots AM,Heeringa P,Brouwer E
Sat Apr 16 00:00:00 UTC 2022
Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.
Nature communications
Sun L,Paschall AV,Middleton DR,Ishihara M,Ozdilek A,Wantuch PL,Aceil J,Duke JA,LaBranche CC,Tiemeyer M,Avci FY
Thu May 21 00:00:00 UTC 2020
In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging.
Scientific reports
Kröger M,Scheffel J,Nikolaev VV,Shirshin EA,Siebenhaar F,Schleusener J,Lademann J,Maurer M,Darvin ME
Thu Sep 10 00:00:00 UTC 2020
The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor.
Scientific reports
Żyżyńska-Granica B,Trzaskowski B,Dutkiewicz M,Zegrocka-Stendel O,Machcińska M,Bocian K,Kowalewska M,Koziak K
Wed Feb 19 00:00:00 UTC 2020
Autologous apoptotic neutrophils inhibit inflammatory cytokine secretion by human dendritic cells, but enhance Th1 responses.
FEBS open bio
Majai GE,Gogolák P,Tóth M,Hodrea J,Horváth D,Fésüs L,Rajnavölgyi É,Bácsi A
Sat Aug 01 00:00:00 UTC 2020
CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation.
Scientific reports
Elmetwali T,Salman A,Wei W,Hussain SA,Young LS,Palmer DH
Wed Jan 15 00:00:00 UTC 2020
Zinc Supplementation Modulates NETs Release and Neutrophils' Degranulation.
Nutrients
Kuźmicka W,Manda-Handzlik A,Cieloch A,Mroczek A,Demkow U,Wachowska M,Ciepiela O
300-03 was used in Flow cytometry/Cell sorting to show that zinc affects neutrophils' functions in vivo and in vitro. Proper zinc level is necessary to maintain efficient functioning of the innate immune response.
Sat Dec 26 00:00:00 UTC 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
300-03 was used in Cell Culture to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 UTC 2020
RHOA-mediated mechanical force generation through Dectin-1.
Journal of cell science
Choraghe RP,Kołodziej T,Buser A,Rajfur Z,Neumann AK
300-03 was used in Cell Culture to find direct evidence for the importance of RHOA-ROCK-MLC signaling in the process of phagocytosis of C. albicans.
Mon Mar 02 00:00:00 UTC 2020
hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts.
EBioMedicine
Todorova D,Zhang Y,Chen Q,Liu J,He J,Fu X,Xu Y
300-03 was used in Cell Culture to investigate whether the adoptive transfer of CTLA4-Ig/PD-L1 knock-in dendritic cell-like cells(CP DCLs) can induce long-term immune tolerance of parental human embryonic stem cells(hESC)-derived smooth muscle and cardiomyocyte allografts.
Tue Dec 01 00:00:00 UTC 2020
Immunomodulatory activity of IR700-labelled affibody targeting HER2.
Cell death & disease
Mączyńska J,Da Pieve C,Burley TA,Raes F,Shah A,Saczko J,Harrington KJ,Kramer-Marek G
Tue Oct 20 00:00:00 UTC 2020
Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.
Communications biology
Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S
Fri Dec 18 00:00:00 UTC 2020
An Elvitegravir Nanoformulation Crosses the Blood-Brain Barrier and Suppresses HIV-1 Replication in Microglia.
Viruses
Gong Y,Zhi K,Nagesh PKB,Sinha N,Chowdhury P,Chen H,Gorantla S,Yallapu MM,Kumar S
300-03 was used in In vitro experiments to investigate ART treatment of HIV-1.
Wed May 20 00:00:00 UTC 2020
Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma.
Frontiers in immunology
Chang Y,Li G,Zhai Y,Huang L,Feng Y,Wang D,Zhang W,Hu H
300-03 was used in Cell Culture to investigate glutaredoxin regulation of glioma.
Mon Jun 21 00:00:00 UTC 2021
Modeling early stage atherosclerosis in a primary human vascular microphysiological system.
Nature communications
Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA
Tue Oct 27 00:00:00 UTC 2020
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer.
Cell reports
Kwak T,Wang F,Deng H,Condamine T,Kumar V,Perego M,Kossenkov A,Montaner LJ,Xu X,Xu W,Zheng C,Schuchter LM,Amaravadi RK,Mitchell TC,Karakousis GC,Mulligan C,Nam B,Masters G,Hockstein N,Bennett J,Nefedova Y,Gabrilovich DI
300-03 was used in In vitro experiments to reveal the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.
Tue Dec 29 00:00:00 UTC 2020
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.
Nature communications
Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
Thu Jul 30 00:00:00 UTC 2020
Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.
Annals of clinical and translational neurology
Zierfuss B,Weinhofer I,Kühl JS,Köhler W,Bley A,Zauner K,Binder J,Martinović K,Seiser C,Hertzberg C,Kemp S,Egger G,Leitner G,Bauer J,Wiesinger C,Kunze M,Forss-Petter S,Berger J
Fri May 01 00:00:00 UTC 2020
Isolation and High Throughput Flow Cytometric Apoptosis Assay of Human Neutrophils to Enable Compound Library Screening.
Bio-protocol
Herman KD,Rahman A,Prince LR
300-03 was used in Sample Preparation (FC/FACS) to determine a more effective strategy for neutrophil isolation from human peripheral blood.
Fri Jun 05 00:00:00 UTC 2020
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
Nature communications
Hara-Chikuma M,Tanaka M,Verkman AS,Yasui M
Mon Nov 09 00:00:00 UTC 2020
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.
Nature communications
Zuo B,Qi H,Lu Z,Chen L,Sun B,Yang R,Zhang Y,Liu Z,Gao X,You A,Wu L,Jing R,Zhou Q,Yin H
Tue Apr 14 00:00:00 UTC 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
300-03 was used in In vitro experiments to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 UTC 2020
Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles.
Nature communications
Halder LD,Jo EAH,Hasan MZ,Ferreira-Gomes M,Krüger T,Westermann M,Palme DI,Rambach G,Beyersdorf N,Speth C,Jacobsen ID,Kniemeyer O,Jungnickel B,Zipfel PF,Skerka C
Mon May 11 00:00:00 UTC 2020
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule.
Cell reports. Medicine
Berezhnoy A,Sumrow BJ,Stahl K,Shah K,Liu D,Li J,Hao SS,De Costa A,Kaul S,Bendell J,Cote GM,Luke JJ,Sanborn RE,Sharma MR,Chen F,Li H,Diedrich G,Bonvini E,Moore PA
300-03 was used in Cell Culture to conclude that MGD019 demonstrates encouraging activity in tumors traditionally unresponsive to checkpoint blockade.
Tue Dec 22 00:00:00 UTC 2020
Immunogenic neoantigens derived from gene fusions stimulate T cell responses.
Nature medicine
Yang W,Lee KW,Srivastava RM,Kuo F,Krishna C,Chowell D,Makarov V,Hoen D,Dalin MG,Wexler L,Ghossein R,Katabi N,Nadeem Z,Cohen MA,Tian SK,Robine N,Arora K,Geiger H,Agius P,Bouvier N,Huberman K,Vanness K,Havel JJ,Sims JS,Samstein RM,Mandal R,Tepe J,Ganly I,Ho AL,Riaz N,Wong RJ,Shukla N,Chan TA,Morris LGT
300-03 was used in Cell Culture to study the gene fusions as a source of immunogenic neoantigens that can mediate responses to immunotherapy.
Wed May 01 00:00:00 UTC 2019
Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.
Cell
Ludwig LS,Lareau CA,Ulirsch JC,Christian E,Muus C,Li LH,Pelka K,Ge W,Oren Y,Brack A,Law T,Rodman C,Chen JH,Boland GM,Hacohen N,Rozenblatt-Rosen O,Aryee MJ,Buenrostro JD,Regev A,Sankaran VG
Thu Mar 07 00:00:00 UTC 2019
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Cell
Huang B,Chen Z,Geng L,Wang J,Liang H,Cao Y,Chen H,Huang W,Su M,Wang H,Xu Y,Liu Y,Lu B,Xian H,Li H,Li H,Ren L,Xie J,Ye L,Wang H,Zhao J,Chen P,Zhang L,Zhao S,Zhang T,Xu B,Che D,Si W,Gu X,Zeng L,Wang Y,Li D,Zhan Y,Delfouneso D,Lew AM,Cui J,Tang WH,Zhang Y,Gong S,Bai F,Yang M,Zhang Y
Thu Nov 14 00:00:00 UTC 2019
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Immunity
Zhao Y,Lee CK,Lin CH,Gassen RB,Xu X,Huang Z,Xiao C,Bonorino C,Lu LF,Bui JD,Hui E
Tue Dec 17 00:00:00 UTC 2019
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 UTC 2019
Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.
Immunity
Takeda A,Hollmén M,Dermadi D,Pan J,Brulois KF,Kaukonen R,Lönnberg T,Boström P,Koskivuo I,Irjala H,Miyasaka M,Salmi M,Butcher EC,Jalkanen S
Tue Sep 17 00:00:00 UTC 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 UTC 2019
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.
Blood
Mill CP,Fiskus W,DiNardo CD,Qian Y,Raina K,Rajapakshe K,Perera D,Coarfa C,Kadia TM,Khoury JD,Saenz DT,Saenz DN,Illendula A,Takahashi K,Kornblau SM,Green MR,Futreal AP,Bushweller JH,Crews CM,Bhalla KN
Thu Jul 04 00:00:00 UTC 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
300-03 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 UTC 2019
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.
The Journal of clinical investigation
Gros A,Tran E,Parkhurst MR,Ilyas S,Pasetto A,Groh EM,Robbins PF,Yossef R,Garcia-Garijo A,Fajardo CA,Prickett TD,Jia L,Gartner JJ,Ray S,Ngo L,Wunderllich JR,Yang JC,Rosenberg SA
Fri Nov 01 00:00:00 UTC 2019
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors.
The Journal of clinical investigation
Chen F,Zou Z,Du J,Su S,Shao J,Meng F,Yang J,Xu Q,Ding N,Yang Y,Liu Q,Wang Q,Sun Z,Zhou S,Du S,Wei J,Liu B
Wed May 01 00:00:00 UTC 2019
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Nature chemical biology
Buter J,Cheng TY,Ghanem M,Grootemaat AE,Raman S,Feng X,Plantijn AR,Ennis T,Wang J,Cotton RN,Layre E,Ramnarine AK,Mayfield JA,Young DC,Jezek Martinot A,Siddiqi N,Wakabayashi S,Botella H,Calderon R,Murray M,Ehrt S,Snider BB,Reed MB,Oldfield E,Tan S,Rubin EJ,Behr MA,van der Wel NN,Minnaard AJ,Moody DB
300-03 was used in Sample Preparation (FC/FACS) to study how Mycobacterium tuberculosis (Mtb)-produced 1-tuberculosinyladenosine (1-TbAd) is a naturally evolved phagolysosome disruptor.
Sun Sep 01 00:00:00 UTC 2019
Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America
Bedard M,Shrestha D,Priestman DA,Wang Y,Schneider F,Matute JD,Iyer SS,Gileadi U,Prota G,Kandasamy M,Veerapen N,Besra G,Fritzsche M,Zeissig S,Shevchenko A,Christianson JC,Platt FM,Eggeling C,Blumberg RS,Salio M,Cerundolo V
Tue Nov 19 00:00:00 UTC 2019
Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway.
Cancer science
Long J,Hu Z,Xue H,Wang Y,Chen J,Tang F,Zhou J,Liu L,Qiu W,Zhang S,Ouyang Y,Ye Y,Xu G,Li L,Zeng Z
Thu Aug 01 00:00:00 UTC 2019
Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Leko V,McDuffie LA,Zheng Z,Gartner JJ,Prickett TD,Apolo AB,Agarwal PK,Rosenberg SA,Lu YC
Sat Jun 15 00:00:00 UTC 2019
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.
Journal of immunology (Baltimore, Md. : 1950)
Krishnamurthy A,Ytterberg AJ,Sun M,Sakuraba K,Steen J,Joshua V,Tarasova NK,Malmström V,Wähämaa H,Réthi B,Catrina AI
Sat Jun 01 00:00:00 UTC 2019
IL-36γ Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Gao Y,Wen Q,Hu S,Zhou X,Xiong W,Du X,Zhang L,Fu Y,Yang J,Zhou C,Zhang Z,Li Y,Liu H,Huang Y,Ma L
Thu Aug 15 00:00:00 UTC 2019
Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors.
Journal of immunology (Baltimore, Md. : 1950)
Paoletti A,Rohmer J,Ly B,Pascaud J,Rivière E,Seror R,Le Goff B,Nocturne G,Mariette X
Tue Oct 01 00:00:00 UTC 2019
Targeting miR-193a-AML1-ETO-β-catenin axis by melatonin suppresses the self-renewal of leukaemia stem cells in leukaemia with t (8;21) translocation.
Journal of cellular and molecular medicine
Zhou B,Ye H,Xing C,Liang B,Li H,Chen L,Huang X,Wu Y,Gao S
Thu Aug 01 00:00:00 UTC 2019
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Nature communications
Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J
Fri Jul 05 00:00:00 UTC 2019
The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway.
Cell death & disease
Ye Z,Zhong L,Zhu S,Wang Y,Zheng J,Wang S,Zhang J,Huang R
Mon Jul 01 00:00:00 UTC 2019
iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.
Nature communications
Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B
Fri Mar 22 00:00:00 UTC 2019
Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA.
Stem cell reports
Brok-Volchanskaya VS,Bennin DA,Suknuntha K,Klemm LC,Huttenlocher A,Slukvin I
Tue Dec 10 00:00:00 UTC 2019
Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation.
Cell death & disease
Zhang H,Qiu SL,Tang QY,Zhou X,Zhang JQ,He ZY,Bai J,Li MH,Deng JM,Liang Y,Zhong XN
Thu Sep 12 00:00:00 UTC 2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Scientific reports
Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL
Thu Nov 14 00:00:00 UTC 2019
The viral protein corona directs viral pathogenesis and amyloid aggregation.
Nature communications
Ezzat K,Pernemalm M,Pålsson S,Roberts TC,Järver P,Dondalska A,Bestas B,Sobkowiak MJ,Levänen B,Sköld M,Thompson EA,Saher O,Kari OK,Lajunen T,Sverremark Ekström E,Nilsson C,Ishchenko Y,Malm T,Wood MJA,Power UF,Masich S,Lindén A,Sandberg JK,Lehtiö J,Spetz AL,El Andaloussi S
Mon May 27 00:00:00 UTC 2019
Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis.
Cell death & disease
Zhou Y,Zhang B,Li C,Huang X,Cheng H,Bao X,Zhao F,Cheng Q,Yue S,Han J,Luo Z
Mon Sep 09 00:00:00 UTC 2019
Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes.
Cell reports
Rodriguez RM,Suarez-Alvarez B,Lavín JL,Ascensión AM,Gonzalez M,Lozano JJ,Raneros AB,Bulnes PD,Vidal-Castiñeira JR,Huidobro C,Martin-Martin C,Sanz AB,Ruiz-Ortega M,Puig-Kröger A,Corbí AL,Araúzo-Bravo MJ,Aransay AM,Lopez-Larrea C
300-03 was used in Cell Culture to study how cells integrate the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines signals which are opposing regulators of the inflammatory program.
Tue Oct 22 00:00:00 UTC 2019
The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus.
Scientific reports
Cataneo AHD,Kuczera D,Koishi AC,Zanluca C,Silveira GF,Arruda TB,Suzukawa AA,Bortot LO,Dias-Baruffi M,Verri WA,Robert AW,Stimamiglio MA,Duarte Dos Santos CN,Wowk PF,Bordignon J
Fri Nov 08 00:00:00 UTC 2019
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Cell death & disease
Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A
Tue May 28 00:00:00 UTC 2019
In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.
Scientific reports
Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B
Wed Feb 13 00:00:00 UTC 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 UTC 2019
Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells.
Blood cancer journal
Fiskus W,Cai T,DiNardo CD,Kornblau SM,Borthakur G,Kadia TM,Pemmaraju N,Bose P,Masarova L,Rajapakshe K,Perera D,Coarfa C,Mill CP,Saenz DT,Saenz DN,Sun B,Khoury JD,Shen Y,Konopleva M,Bhalla KN
Tue Jan 15 00:00:00 UTC 2019
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.
Frontiers in immunology
Lara-Reyna S,Scambler T,Holbrook J,Wong C,Jarosz-Griffiths HH,Martinon F,Savic S,Peckham D,McDermott MF
300-03 was used in Sample Preparation (FC/FACS) to investigate signalling pathways following cystic fibrosis transmembrane conductance regulator mutations.
Tue Oct 13 00:00:00 UTC 2020
Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
Molecular cell
Aarreberg LD,Esser-Nobis K,Driscoll C,Shuvarikov A,Roby JA,Gale M
300-03 was used in Cell Culture to identify a new function for IL-1β in the onset or enhancement of cell-intrinsic immunity, with important implications for cGAS-STING in integrating inflammatory and microbial cues for host defense.
Thu May 16 00:00:00 UTC 2019
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
The Journal of biological chemistry
Dupont L,Du L,Poulter M,Choi S,McIntosh M,Reeves MB
Fri Aug 30 00:00:00 UTC 2019
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Nature communications
Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C
Tue Dec 10 00:00:00 UTC 2019
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 UTC 2018
Transcription Elongation Can Affect Genome 3D Structure.
Cell
Heinz S,Texari L,Hayes MGB,Urbanowski M,Chang MW,Givarkes N,Rialdi A,White KM,Albrecht RA,Pache L,Marazzi I,García-Sastre A,Shaw ML,Benner C
Thu Sep 06 00:00:00 UTC 2018
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.
Cell
Brumbaugh J,Di Stefano B,Wang X,Borkent M,Forouzmand E,Clowers KJ,Ji F,Schwarz BA,Kalocsay M,Elledge SJ,Chen Y,Sadreyev RI,Gygi SP,Hu G,Shi Y,Hochedlinger K
Thu Jan 11 00:00:00 UTC 2018
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
Thu Oct 04 00:00:00 UTC 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
300-03 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.
Thu Sep 20 00:00:00 UTC 2018
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.
Cell
Wroblewska A,Dhainaut M,Ben-Zvi B,Rose SA,Park ES,Amir ED,Bektesevic A,Baccarini A,Merad M,Rahman AH,Brown BD
Thu Nov 01 00:00:00 UTC 2018
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Cell
Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J
Thu Jan 11 00:00:00 UTC 2018
A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization.
Cell
Hansen MMK,Wen WY,Ingerman E,Razooky BS,Thompson CE,Dar RD,Chin CW,Simpson ML,Weinberger LS
Thu Jun 14 00:00:00 UTC 2018
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Immunity
Guo C,Chi Z,Jiang D,Xu T,Yu W,Wang Z,Chen S,Zhang L,Liu Q,Guo X,Zhang X,Li W,Lu L,Wu Y,Song BL,Wang D
Tue Nov 20 00:00:00 UTC 2018
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.
Immunity
Proto JD,Doran AC,Gusarova G,Yurdagul A,Sozen E,Subramanian M,Islam MN,Rymond CC,Du J,Hook J,Kuriakose G,Bhattacharya J,Tabas I
Tue Oct 16 00:00:00 UTC 2018
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Cancer cell
Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH
Mon Jan 08 00:00:00 UTC 2018
Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.
Cell host & microbe
Johnson JS,Lucas SY,Amon LM,Skelton S,Nazitto R,Carbonetti S,Sather DN,Littman DR,Aderem A
300-03 was used in Cell Culture to study how dendritic cells (DCs) detect HIV-1 in distinct phases, before and after virus integration in response to reverse transcription.
Wed Mar 14 00:00:00 UTC 2018
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.
The Journal of clinical investigation
Mao L,Kitani A,Similuk M,Oler AJ,Albenberg L,Kelsen J,Aktay A,Quezado M,Yao M,Montgomery-Recht K,Fuss IJ,Strober W
Tue May 01 00:00:00 UTC 2018
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
The Journal of clinical investigation
Chen HM,van der Touw W,Wang YS,Kang K,Mai S,Zhang J,Alsina-Beauchamp D,Duty JA,Mungamuri SK,Zhang B,Moran T,Flavell R,Aaronson S,Hu HM,Arase H,Ramanathan S,Flores R,Pan PY,Chen SH
Mon Dec 03 00:00:00 UTC 2018
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.
The Journal of experimental medicine
Kelly A,Gunaltay S,McEntee CP,Shuttleworth EE,Smedley C,Houston SA,Fenton TM,Levison S,Mann ER,Travis MA
Mon Nov 05 00:00:00 UTC 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
300-03 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 UTC 2018
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Frontiers in immunology
Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M
300-03 was used in In vitro experiments to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.
Mon Apr 08 00:00:00 UTC 2019
Lymphatic exosomes promote dendritic cell migration along guidance cues.
The Journal of cell biology
Brown M,Johnson LA,Leone DA,Majek P,Vaahtomeri K,Senfter D,Bukosza N,Schachner H,Asfour G,Langer B,Hauschild R,Parapatics K,Hong YK,Bennett KL,Kain R,Detmar M,Sixt M,Jackson DG,Kerjaschki D
Mon Jun 04 00:00:00 UTC 2018
Infection with flaviviruses requires BCLXL for cell survival.
PLoS pathogens
Suzuki T,Okamoto T,Katoh H,Sugiyama Y,Kusakabe S,Tokunaga M,Hirano J,Miyata Y,Fukuhara T,Ikawa M,Satoh T,Yoshio S,Suzuki R,Saijo M,Huang DCS,Kanto T,Akira S,Matsuura Y
300-03 was used in In vitro experiments to suggest that BCLXL plays a crucial role in the survival of cells infected with flaviviruses, and that BCLXL may provide a novel antiviral target to suppress propagation of the family of Flaviviridae viruses.
Sat Sep 01 00:00:00 UTC 2018
X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.
Molecular oncology
Zhou J,Lu X,Tan TZ,Chng WJ
Mon Jan 01 00:00:00 UTC 2018
ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Layhadi JA,Turner J,Crossman D,Fountain SJ
Thu Feb 01 00:00:00 UTC 2018
Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1α and Increased Hexokinase II Expression.
Journal of immunology (Baltimore, Md. : 1950)
Perrin-Cocon L,Aublin-Gex A,Diaz O,Ramière C,Peri F,André P,Lotteau V
Sat Sep 01 00:00:00 UTC 2018
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.
Journal of immunology (Baltimore, Md. : 1950)
van der Touw W,Kang K,Luan Y,Ma G,Mai S,Qin L,Bian G,Zhang R,Mungamuri SK,Hu HM,Zhang CC,Aaronson SA,Feldmann M,Yang WC,Chen SH,Pan PY
Sat Sep 15 00:00:00 UTC 2018
Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H
Thu Nov 15 00:00:00 UTC 2018
Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Singh T,Fakiola M,Oommen J,Singh AP,Singh AK,Smith N,Chakravarty J,Sundar S,Blackwell JM
Sun Apr 15 00:00:00 UTC 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 UTC 2018
A malaria protein factor induces IL-4 production by dendritic cells via PI3K-Akt-NF-κB signaling independent of MyD88/TRIF and promotes Th2 response.
The Journal of biological chemistry
Wu X,Gowda NM,Kawasawa YI,Gowda DC
Fri Jul 06 00:00:00 UTC 2018
A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.
Nature communications
Sumide K,Matsuoka Y,Kawamura H,Nakatsuka R,Fujioka T,Asano H,Takihara Y,Sonoda Y
Wed Jun 06 00:00:00 UTC 2018
NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
JCI insight
Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC
300-03 was used in In vitro experiments to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.
Thu Nov 15 00:00:00 UTC 2018
Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.
The Journal of biological chemistry
Melo-Gonzalez F,Fenton TM,Forss C,Smedley C,Goenka A,MacDonald AS,Thornton DJ,Travis MA
Fri Jun 01 00:00:00 UTC 2018
IFITM proteins inhibit HIV-1 protein synthesis.
Scientific reports
Lee WJ,Fu RM,Liang C,Sloan RD
Fri Sep 28 00:00:00 UTC 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 UTC 2018
Personalized identification of tumor-associated immunogenic neoepitopes in hepatocellular carcinoma in complete remission after sorafenib treatment.
Oncotarget
Vrecko S,Guenat D,Mercier-Letondal P,Faucheu H,Dosset M,Royer B,Galaine J,Boidot R,Kim S,Jary M,Adotévi O,Borg C,Godet Y
300-03 was used in In vitro experiments to report and investigate the case of a patient diagnosed with an advanced hepatocellular carcinoma treated by sorafenib who experienced a complete histological response.
Tue Oct 23 00:00:00 UTC 2018
IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.
Cell reports
Gkirtzimanaki K,Kabrani E,Nikoleri D,Polyzos A,Blanas A,Sidiropoulos P,Makrigiannakis A,Bertsias G,Boumpas DT,Verginis P
300-03 was used in Cell Culture to demonstrate IFNα-mediated deregulation of mitochondrial metabolism and impairment of autophagic degradation, leading to cytosolic accumulation of mtDNA that is sensed via stimulator of interferon genes (STING) to promote induction of autoinflammatory DCs.
Tue Oct 23 00:00:00 UTC 2018
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.
Nature communications
Piragyte I,Clapes T,Polyzou A,Klein Geltink RI,Lefkopoulos S,Yin N,Cauchy P,Curtis JD,Klaeylé L,Langa X,Beckmann CCA,Wlodarski MW,Müller P,Van Essen D,Rambold A,Kapp FG,Mione M,Buescher JM,Pearce EL,Polyzos A,Trompouki E
Mon Aug 06 00:00:00 UTC 2018
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
Nature communications
Offenbacher S,Jiao Y,Kim SJ,Marchesan J,Moss KL,Jing L,Divaris K,Bencharit S,Agler CS,Morelli T,Zhang S,Sun L,Seaman WT,Cowley D,Barros SP,Beck JD,Munz M,Schaefer AS,North KE
Tue Sep 11 00:00:00 UTC 2018
M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.
Cell death & disease
Sheng J,Yang Y,Cui Y,He S,Wang L,Liu L,He Q,Lv T,Han W,Yu W,Hu S,Jin J
Mon Jul 09 00:00:00 UTC 2018
Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes.
Scientific reports
Domenis R,Cifù A,Quaglia S,Pistis C,Moretti M,Vicario A,Parodi PC,Fabris M,Niazi KR,Soon-Shiong P,Curcio F
Thu Sep 06 00:00:00 UTC 2018
The oligosaccharides 6'-sialyllactose, 2'-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation.
PloS one
Perdijk O,van Neerven RJJ,van den Brink E,Savelkoul HFJ,Brugman S
300-03 was used in Cell Culture to study the effect of human milk oligosaccharides (HMOs) 6'-sialyllactose (6'SL) and 2'-fucosyllactose (2'FL) as well as prebiotic galactooligosaccharides (GOS) on dendritic cell (DC) differentiation and maturation to study how HMOs contribute to immune homeostasis and protection against disease.
Tue Jan 22 00:00:00 UTC 2019
Characterization of TRKA signaling in acute myeloid leukemia.
Oncotarget
Herbrich SM,Kannan S,Nolo RM,Hornbaker M,Chandra J,Zweidler-McKay PA
300-03 was used in Cell Culture to study the role of tropomyosin-related kinase A (TRKA) signaling in normal and leukemic cells.
Tue Jul 10 00:00:00 UTC 2018
Regulation of IL-22BP in psoriasis.
Scientific reports
Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC
Fri Mar 23 00:00:00 UTC 2018
Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential.
Nature communications
Wampach L,Heintz-Buschart A,Fritz JV,Ramiro-Garcia J,Habier J,Herold M,Narayanasamy S,Kaysen A,Hogan AH,Bindl L,Bottu J,Halder R,Sjöqvist C,May P,Andersson AF,de Beaufort C,Wilmes P
Fri Nov 30 00:00:00 UTC 2018
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling.
Scientific reports
Nzou G,Wicks RT,Wicks EE,Seale SA,Sane CH,Chen A,Murphy SV,Jackson JD,Atala AJ
Wed May 09 00:00:00 UTC 2018
March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.
Nature communications
Borges TJ,Murakami N,Machado FD,Murshid A,Lang BJ,Lopes RL,Bellan LM,Uehara M,Antunes KH,Pérez-Saéz MJ,Birrane G,Vianna P,Gonçalves JIB,Zanin RF,Azzi J,Abdi R,Ishido S,Shin JS,Souza APD,Calderwood SK,Riella LV,Bonorino C
Tue Aug 28 00:00:00 UTC 2018
A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease.
Bioengineering & translational medicine
McKay R,Ghodasra M,Schardt J,Quan D,Pottash AE,Shang W,Jay SM,Payne GF,Chang MW,March JC,Bentley WE
Sat Sep 01 00:00:00 UTC 2018
Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells.
Emerging microbes & infections
Sirmarova J,Salat J,Palus M,Hönig V,Langhansova H,Holbrook MR,Ruzek D
Wed Nov 07 00:00:00 UTC 2018
Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro.
Scientific reports
Bruno V,Svensson-Arvelund J,Rubér M,Berg G,Piccione E,Jenmalm MC,Ernerudh J
Thu Mar 08 00:00:00 UTC 2018
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Cell reports
Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M
300-03 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.
Tue Aug 14 00:00:00 UTC 2018
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Nature communications
Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH
Fri Sep 14 00:00:00 UTC 2018
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Nature communications
Pein H,Ville A,Pace S,Temml V,Garscha U,Raasch M,Alsabil K,Viault G,Dinh CP,Guilet D,Troisi F,Neukirch K,König S,Bilancia R,Waltenberger B,Stuppner H,Wallert M,Lorkowski S,Weinigel C,Rummler S,Birringer M,Roviezzo F,Sautebin L,Helesbeux JJ,Séraphin D,Mosig AS,Schuster D,Rossi A,Richomme P,Werz O,Koeberle A
Thu Sep 20 00:00:00 UTC 2018
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Nature communications
Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W
Tue Sep 25 00:00:00 UTC 2018
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.
Nature communications
Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R
Wed Aug 29 00:00:00 UTC 2018
Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets.
Nature communications
Aulicino A,Rue-Albrecht KC,Preciado-Llanes L,Napolitani G,Ashley N,Cribbs A,Koth J,Lagerholm BC,Ambrose T,Gordon MA,Sims D,Simmons A
Mon Nov 19 00:00:00 UTC 2018
Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.
Stem cell reports
Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ
Tue Apr 10 00:00:00 UTC 2018
Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.
Scientific reports
Shinde P,Fernandes S,Melinkeri S,Kale V,Limaye L
Mon Apr 09 00:00:00 UTC 2018
IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.
Scientific reports
Ahsan F,Maertzdorf J,Guhlich-Bornhof U,Kaufmann SHE,Moura-Alves P
Wed Jan 24 00:00:00 UTC 2018
Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.
Scientific reports
Järver P,Dondalska A,Poux C,Sandberg A,Bergenstråhle J,Sköld AE,Dereuddre-Bosquet N,Martinon F,Pålsson S,Zaghloul E,Brodin D,Sander B,Lennox KA,Behlke MA,El-Andaloussi S,Lehtiö J,Lundeberg J,LeGrand R,Spetz AL
Fri Oct 26 00:00:00 UTC 2018
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.
Nature communications
Schott K,Fuchs NV,Derua R,Mahboubi B,Schnellbächer E,Seifried J,Tondera C,Schmitz H,Shepard C,Brandariz-Nuñez A,Diaz-Griffero F,Reuter A,Kim B,Janssens V,König R
Fri Jun 08 00:00:00 UTC 2018
Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases.
Scientific reports
Chang LL,Hsu WH,Kao MC,Chou CC,Lin CC,Liu CJ,Weng BC,Kuo FC,Kuo CH,Lin MH,Wang CJ,Lin CH,Wu DC,Huang SK
Wed Feb 28 00:00:00 UTC 2018
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Nature
Wartewig T,Kurgyis Z,Keppler S,Pechloff K,Hameister E,Öllinger R,Maresch R,Buch T,Steiger K,Winter C,Rad R,Ruland J
Thu Dec 07 00:00:00 UTC 2017
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
Cell
Wang Y,Subramanian M,Yurdagul A,Barbosa-Lorenzi VC,Cai B,de Juan-Sanz J,Ryan TA,Nomura M,Maxfield FR,Tabas I
Thu Oct 05 00:00:00 UTC 2017
High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.
Immunity
Alcántara-Hernández M,Leylek R,Wagar LE,Engleman EG,Keler T,Marinkovich MP,Davis MM,Nolan GP,Idoyaga J
Tue Dec 19 00:00:00 UTC 2017
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Cell metabolism
Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E
300-03 was used in In vitro experiments to study the contributions of intracellular glucose stores to glucose sourcing for the support of dendritic cell activation.
Tue Sep 05 00:00:00 UTC 2017
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Blood
Tarafdar A,Hopcroft LE,Gallipoli P,Pellicano F,Cassels J,Hair A,Korfi K,Jørgensen HG,Vetrie D,Holyoake TL,Michie AM
Thu Jan 12 00:00:00 UTC 2017
CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.
Blood
Greiner G,Witzeneder N,Berger A,Schmetterer K,Eisenwort G,Schiefer AI,Roos S,Popow-Kraupp T,Müllauer L,Zuber J,Sexl V,Kenner L,Sperr WR,Valent P,Mayerhofer M,Hoermann G
Thu Jan 19 00:00:00 UTC 2017
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.
Blood
Karjalainen R,Pemovska T,Popa M,Liu M,Javarappa KK,Majumder MM,Yadav B,Tamborero D,Tang J,Bychkov D,Kontro M,Parsons A,Suvela M,Mayoral Safont M,Porkka K,Aittokallio T,Kallioniemi O,McCormack E,Gjertsen BT,Wennerberg K,Knowles J,Heckman CA
Thu Aug 10 00:00:00 UTC 2017
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
The Journal of clinical investigation
Doran AC,Ozcan L,Cai B,Zheng Z,Fredman G,Rymond CC,Dorweiler B,Sluimer JC,Hsieh J,Kuriakose G,Tall AR,Tabas I
Wed Nov 01 00:00:00 UTC 2017
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Nature chemical biology
Johannessen L,Sundberg TB,O'Connell DJ,Kolde R,Berstler J,Billings KJ,Khor B,Seashore-Ludlow B,Fassl A,Russell CN,Latorre IJ,Jiang B,Graham DB,Perez JR,Sicinski P,Phillips AJ,Schreiber SL,Gray NS,Shamji AF,Xavier RJ
300-03 was used in Cell Culture to identify a function for CDK8 and CDK19 in regulating innate immune activation and suggest that these kinases may warrant consideration as therapeutic targets for inflammatory disorders.
Sun Oct 01 00:00:00 UTC 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 UTC 2017
Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis.
Journal of immunology (Baltimore, Md. : 1950)
Björnfot Holmström S,Clark R,Zwicker S,Bureik D,Kvedaraite E,Bernasconi E,Nguyen Hoang AT,Johannsen G,Marsland BJ,Boström EA,Svensson M
Fri Dec 15 00:00:00 UTC 2017
Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Salio M,Gasser O,Gonzalez-Lopez C,Martens A,Veerapen N,Gileadi U,Verter JG,Napolitani G,Anderson R,Painter G,Besra GS,Hermans IF,Cerundolo V
Sun Oct 15 00:00:00 UTC 2017
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Gibson A,Faulkner L,Lichtenfels M,Ogese M,Al-Attar Z,Alfirevic A,Esser PR,Martin SF,Pirmohamed M,Park BK,Naisbitt DJ
Tue Aug 15 00:00:00 UTC 2017
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.
Scientific reports
Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E
Tue Oct 17 00:00:00 UTC 2017
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.
The Journal of biological chemistry
Takano T,Motozono C,Imai T,Sonoda KH,Nakanishi Y,Yamasaki S
Fri Oct 13 00:00:00 UTC 2017
Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.
Bio-protocol
Sontag S,Förster M,Seré K,Zenke M
300-03 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.
Sat Aug 05 00:00:00 UTC 2017
Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells.
Scientific reports
Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A
Mon Nov 06 00:00:00 UTC 2017
Analysis of Mitochondrial Transfer in Direct Co-cultures of Human Monocyte-derived Macrophages (MDM) and Mesenchymal Stem Cells (MSC).
Bio-protocol
Jackson MV,Krasnodembskaya AD
300-03 was used in In vitro experiments to study mesenchymal stem stromal cell contact-dependent communication with alveolar macrophages.
Fri May 05 00:00:00 UTC 2017
Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.
Scientific reports
Nie Y,Yang D,Trivett A,Han Z,Xin H,Chen X,Oppenheim JJ
Fri Oct 27 00:00:00 UTC 2017
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
The Journal of biological chemistry
Riess M,Fuchs NV,Idica A,Hamdorf M,Flory E,Pedersen IM,König R
Fri Jan 06 00:00:00 UTC 2017
Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells.
Scientific reports
Strasser L,Dang HH,Schwarz H,Asam C,Ferreira F,Horejs-Hoeck J,Huber CG
Thu Nov 30 00:00:00 UTC 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 UTC 2017
Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils.
Scientific reports
Alvarez KLF,Beldi M,Sarmanho F,Rossetti RAM,Silveira CRF,Mota GR,Andreoli MA,Caruso EDC,Kamillos MF,Souza AM,Mastrocalla H,Clavijo-Salomon MA,Barbuto JAM,Lorenzi NP,Longatto-Filho A,Baracat E,Lopez RVM,Villa LL,Tacla M,Lepique AP
Mon Aug 21 00:00:00 UTC 2017
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
The Journal of biological chemistry
Nadeau SA,An W,Mohapatra BC,Mushtaq I,Bielecki TA,Luan H,Zutshi N,Ahmad G,Storck MD,Sanada M,Ogawa S,Band V,Band H
Fri Mar 03 00:00:00 UTC 2017
Loss of the clock protein PER2 shortens the erythrocyte life span in mice.
The Journal of biological chemistry
Sun Q,Zhao Y,Yang Y,Yang X,Li M,Xu X,Wen D,Wang J,Zhang J
Fri Jul 28 00:00:00 UTC 2017
An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer.
Scientific reports
Chen Y,Zhao Z,Chen Y,Lv Z,Ding X,Wang R,Xiao H,Hou C,Shen B,Feng J,Guo R,Li Y,Peng H,Han G,Chen G
Tue Aug 15 00:00:00 UTC 2017
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
Nature communications
Veglia F,Tyurin VA,Mohammadyani D,Blasi M,Duperret EK,Donthireddy L,Hashimoto A,Kapralov A,Amoscato A,Angelini R,Patel S,Alicea-Torres K,Weiner D,Murphy ME,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
Thu Dec 14 00:00:00 UTC 2017
Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.
PloS one
Min C,Moore N,Shearstone JR,Quayle SN,Huang P,van Duzer JH,Jarpe MB,Jones SS,Yang M
300-03 was used in Sample Preparation (FC/FACS) to support the clinical evaluation of selective HDAC1/2 inhibitors in combination with azacitidine in AML patients.
Tue Aug 15 00:00:00 UTC 2017
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.
Nature medicine
Fang J,Liu X,Bolanos L,Barker B,Rigolino C,Cortelezzi A,Oliva EN,Cuzzola M,Grimes HL,Fontanillo C,Komurov K,MacBeth K,Starczynowski DT
300-03 was used in Cell Culture to examine the gene regulatory networks that mediate lenalidomide-responsiveness in a myelodysplastic syndrome cell line.
Fri Jul 01 00:00:00 UTC 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 UTC 2016
Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.
Blood
Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J
Thu Jan 28 00:00:00 UTC 2016
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.
The Journal of clinical investigation
Jin Y,Zhou J,Xu F,Jin B,Cui L,Wang Y,Du X,Li J,Li P,Ren R,Pan J
Mon Oct 03 00:00:00 UTC 2016
The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
The Journal of experimental medicine
Chorny A,Casas-Recasens S,Sintes J,Shan M,Polentarutti N,García-Escudero R,Walland AC,Yeiser JR,Cassis L,Carrillo J,Puga I,Cunha C,Bastos H,Rodrigues F,Lacerda JF,Morais A,Dieguez-Gonzalez R,Heeger PS,Salvatori G,Carvalho A,Garcia-Sastre A,Blander JM,Mantovani A,Garlanda C,Cerutti A
Mon Sep 19 00:00:00 UTC 2016
Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
The Journal of experimental medicine
Baron L,Paatero AO,Morel JD,Impens F,Guenin-Macé L,Saint-Auret S,Blanchard N,Dillmann R,Niang F,Pellegrini S,Taunton J,Paavilainen VO,Demangel C
Mon Dec 12 00:00:00 UTC 2016
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Cai B,Thorp EB,Doran AC,Subramanian M,Sansbury BE,Lin CS,Spite M,Fredman G,Tabas I
Tue Jun 07 00:00:00 UTC 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
Tue Oct 25 00:00:00 UTC 2016
Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus.
European journal of immunology
Pichulik T,Khatamzas E,Liu X,Brain O,Delmiro Garcia M,Leslie A,Danis B,Mayer A,Baban D,Ragoussis J,Weber AN,Simmons A
Fri Jan 01 00:00:00 UTC 2016
Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation.
Oncogenesis
Cheng JT,Deng YN,Yi HM,Wang GY,Fu BS,Chen WJ,Liu W,Tai Y,Peng YW,Zhang Q
Mon Feb 22 00:00:00 UTC 2016
The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
Journal of immunology (Baltimore, Md. : 1950)
Tosh KW,Mittereder L,Bonne-Annee S,Hieny S,Nutman TB,Singer SM,Sher A,Jankovic D
Fri Jan 01 00:00:00 UTC 2016
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950)
Paquin-Proulx D,Gibbs A,Bächle SM,Checa A,Introini A,Leeansyah E,Wheelock CE,Nixon DF,Broliden K,Tjernlund A,Moll M,Sandberg JK
Thu Sep 01 00:00:00 UTC 2016
MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.
Journal of immunology (Baltimore, Md. : 1950)
Wen Q,Zhou C,Xiong W,Su J,He J,Zhang S,Du X,Liu S,Wang J,Ma L
Fri Jul 15 00:00:00 UTC 2016
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A
Tue Nov 15 00:00:00 UTC 2016
Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Udgata A,Qureshi R,Mukhopadhyay S
Thu Sep 01 00:00:00 UTC 2016
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Galaine J,Kellermann G,Guillaume Y,Boidot R,Picard E,Loyon R,Queiroz L,Boullerot L,Beziaud L,Jary M,Mansi L,André C,Lethier L,Ségal-Bendirdjian E,Borg C,Godet Y,Adotévi O
Thu Sep 01 00:00:00 UTC 2016
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Cell cycle (Georgetown, Tex.)
Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A
300-03 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.
Mon May 02 00:00:00 UTC 2016
Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF.
FEBS open bio
Yamane K,Leung KP
Thu Sep 01 00:00:00 UTC 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 UTC 2016
Immunomodulation of Lactobacillus rhamnosus GG (LGG)-derived soluble factors on antigen-presenting cells of healthy blood donors.
Scientific reports
Fong FLY,Kirjavainen PV,El-Nezami H
Thu Mar 10 00:00:00 UTC 2016
CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.
Scientific reports
Su S,Hu B,Shao J,Shen B,Du J,Du Y,Zhou J,Yu L,Zhang L,Chen F,Sha H,Cheng L,Meng F,Zou Z,Huang X,Liu B
Thu Jan 28 00:00:00 UTC 2016
Subgroup J avian leukosis virus infection of chicken dendritic cells induces apoptosis via the aberrant expression of microRNAs.
Scientific reports
Liu D,Dai M,Zhang X,Cao W,Liao M
Mon Feb 01 00:00:00 UTC 2016
Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.
The Journal of biological chemistry
Song X,Ding Y,Liu G,Yang X,Zhao R,Zhang Y,Zhao X,Anderson GJ,Nie G
Fri Apr 15 00:00:00 UTC 2016
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Cell death & disease
Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G
Thu Sep 08 00:00:00 UTC 2016
Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Scientific reports
Chung IC,OuYang CN,Yuan SN,Li HP,Chen JT,Shieh HR,Chen YJ,Ojcius DM,Chu CL,Yu JS,Chang YS,Chen LC
Mon Oct 31 00:00:00 UTC 2016
Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.
Stem cell reports
Saxena S,Rönn RE,Guibentif C,Moraghebi R,Woods NB
Tue May 10 00:00:00 UTC 2016
Lactobacillus reuteri and Staphylococcus aureus differentially influence the generation of monocyte-derived dendritic cells and subsequent autologous T cell responses.
Immunity, inflammation and disease
Haileselassie Y,Navis M,Vu N,Qazi KR,Rethi B,Sverremark-Ekström E
Thu Sep 01 00:00:00 UTC 2016
The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling.
Cell death & disease
Vier J,Groth M,Sochalska M,Kirschnek S
Thu Feb 18 00:00:00 UTC 2016
MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.
Scientific reports
Fordham JB,Guilfoyle K,Naqvi AR,Nares S
Tue Apr 26 00:00:00 UTC 2016
Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.
Scientific reports
Gröger M,Rennert K,Giszas B,Weiß E,Dinger J,Funke H,Kiehntopf M,Peters FT,Lupp A,Bauer M,Claus RA,Huber O,Mosig AS
Tue Feb 23 00:00:00 UTC 2016
Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome.
Scientific reports
Wood LW,Cox NI,Phelps CA,Lai SC,Poddar A,Talbot C,Mu D
Thu Feb 25 00:00:00 UTC 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
Wed Apr 06 00:00:00 UTC 2016
miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.
Scientific reports
Naqvi AR,Fordham JB,Ganesh B,Nares S
Fri Sep 09 00:00:00 UTC 2016
Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype.
Scientific reports
Harfuddin Z,Dharmadhikari B,Wong SC,Duan K,Poidinger M,Kwajah S,Schwarz H
Tue Jul 19 00:00:00 UTC 2016
Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity.
mAbs
Karle A,Spindeldreher S,Kolbinger F
300-03 was used in Cell Culture to evaluate its immunogenicity potential by applying 2 different in vitro assays: T-cell activation and major histocompatibility complex-associated peptide proteomics (MAPPs).
Tue Dec 13 00:00:00 UTC 2016
Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure.
Scientific reports
Hogan LE,Jones DC,Allen RL
Wed Feb 24 00:00:00 UTC 2016
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
Nature medicine
Tada T,Zhang Y,Koyama T,Tobiume M,Tsunetsugu-Yokota Y,Yamaoka S,Fujita H,Tokunaga K
Tue Dec 01 00:00:00 UTC 2015
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Nature
Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG
Thu May 07 00:00:00 UTC 2015
Real-time deformability cytometry: on-the-fly cell mechanical phenotyping.
Nature methods
Otto O,Rosendahl P,Mietke A,Golfier S,Herold C,Klaue D,Girardo S,Pagliara S,Ekpenyong A,Jacobi A,Wobus M,Töpfner N,Keyser UF,Mansfeld J,Fischer-Friedrich E,Guck J
Sun Mar 01 00:00:00 UTC 2015
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Blood
Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R
Thu Jan 08 00:00:00 UTC 2015
Circulating precursors of human CD1c+ and CD141+ dendritic cells.
The Journal of experimental medicine
Breton G,Lee J,Zhou YJ,Schreiber JJ,Keler T,Puhr S,Anandasabapathy N,Schlesinger S,Caskey M,Liu K,Nussenzweig MC
Mon Mar 09 00:00:00 UTC 2015
Bee venom processes human skin lipids for presentation by CD1a.
The Journal of experimental medicine
Bourgeois EA,Subramaniam S,Cheng TY,De Jong A,Layre E,Ly D,Salimi M,Legaspi A,Modlin RL,Salio M,Cerundolo V,Moody DB,Ogg G
Mon Feb 09 00:00:00 UTC 2015
CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
The Journal of experimental medicine
Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C
Mon Jul 27 00:00:00 UTC 2015
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.
The Journal of experimental medicine
Lee J,Breton G,Oliveira TY,Zhou YJ,Aljoufi A,Puhr S,Cameron MJ,Sékaly RP,Nussenzweig MC,Liu K
Mon Mar 09 00:00:00 UTC 2015
Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response.
Proceedings of the National Academy of Sciences of the United States of America
Chen JT,Chen CH,Ku KL,Hsiao M,Chiang CP,Hsu TL,Chen MH,Wong CH
Tue Oct 20 00:00:00 UTC 2015
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.
Proceedings of the National Academy of Sciences of the United States of America
McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R
Tue Mar 31 00:00:00 UTC 2015
Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.
European journal of immunology
Kelly C,Swadling L,Brown A,Capone S,Folgori A,Salio M,Klenerman P,Barnes E
Thu Jan 01 00:00:00 UTC 2015
miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Naqvi AR,Fordham JB,Nares S
Sun Feb 15 00:00:00 UTC 2015
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hou TZ,Qureshi OS,Wang CJ,Baker J,Young SP,Walker LS,Sansom DM
Sun Mar 01 00:00:00 UTC 2015
Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Baharom F,Thomas S,Bieder A,Hellmér M,Volz J,Sandgren KJ,McInerney GM,Karlsson Hedestam GB,Mellman I,Smed-Sörensen A
Fri May 01 00:00:00 UTC 2015
The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Svensson-Arvelund J,Mehta RB,Lindau R,Mirrasekhian E,Rodriguez-Martinez H,Berg G,Lash GE,Jenmalm MC,Ernerudh J
Sun Feb 15 00:00:00 UTC 2015
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950)
Hong SS,Choi JH,Lee SY,Park YH,Park KY,Lee JY,Kim J,Gajulapati V,Goo JI,Singh S,Lee K,Kim YK,Im SH,Ahn SH,Rose-John S,Heo TH,Choi Y
Wed Jul 01 00:00:00 UTC 2015
LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.
Journal of immunology (Baltimore, Md. : 1950)
Tatematsu M,Funami K,Ishii N,Seya T,Obuse C,Matsumoto M
Sun Nov 15 00:00:00 UTC 2015
Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.
Journal of immunology (Baltimore, Md. : 1950)
Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH
Thu Oct 15 00:00:00 UTC 2015
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Journal of immunology (Baltimore, Md. : 1950)
Rossetti M,Spreafico R,Saidin S,Chua C,Moshref M,Leong JY,Tan YK,Thumboo J,van Loosdregt J,Albani S
Thu Jan 01 00:00:00 UTC 2015
Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Toniolo PA,Liu S,Yeh JE,Moraes-Vieira PM,Walker SR,Vafaizadeh V,Barbuto JA,Frank DA
Wed Apr 01 00:00:00 UTC 2015
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.
The Journal of biological chemistry
Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS
Fri Jan 23 00:00:00 UTC 2015
Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy.
Oncotarget
Hemminki O,Parviainen S,Juhila J,Turkki R,Linder N,Lundin J,Kankainen M,Ristimäki A,Koski A,Liikanen I,Oksanen M,Nettelbeck DM,Kairemo K,Partanen K,Joensuu T,Kanerva A,Hemminki A
300-03 was used in In vitro experiments to suggest that virus induced oncolysis can enhance anti-tumor immunity and break immune tolerance.
Sat Feb 28 00:00:00 UTC 2015
Serial analysis of 38 proteins during the progression of human breast tumor in mice using an antibody colocalization microarray.
Molecular & cellular proteomics : MCP
Li H,Bergeron S,Annis MG,Siegel PM,Juncker D
Wed Apr 01 00:00:00 UTC 2015
Human dendritic cell DC-SIGN and TLR-2 mediate complementary immune regulatory activities in response to Lactobacillus rhamnosus JB-1.
PloS one
Konieczna P,Schiavi E,Ziegler M,Groeger D,Healy S,Grant R,O'Mahony L
300-03 was used in Sample Preparation (FC/FACS) to study the mechanisms underlying the immunoregulatory and protective effects of lactobacilli strains in the mammalian large intestine.
Tue Mar 15 00:00:00 UTC 2016
IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.
Blood cancer journal
Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM
Fri Jul 31 00:00:00 UTC 2015
Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements.
Scientific reports
Shrivastava A,Prasad A,Kuzontkoski PM,Yu J,Groopman JE
Thu Nov 19 00:00:00 UTC 2015
The effect of short-chain fatty acids on human monocyte-derived dendritic cells.
Scientific reports
Nastasi C,Candela M,Bonefeld CM,Geisler C,Hansen M,Krejsgaard T,Biagi E,Andersen MH,Brigidi P,Ødum N,Litman T,Woetmann A
Fri Nov 06 00:00:00 UTC 2015
Galectin-1 regulates tissue exit of specific dendritic cell populations.
The Journal of biological chemistry
Thiemann S,Man JH,Chang MH,Lee B,Baum LG
Fri Sep 11 00:00:00 UTC 2015
Mica Nanoparticle, STB-HO Eliminates the Human Breast Carcinoma Cells by Regulating the Interaction of Tumor with its Immune Microenvironment.
Scientific reports
Kang TW,Kim HS,Lee BC,Shin TH,Choi SW,Kim YJ,Lee HY,Jung YK,Seo KW,Kang KS
Thu Dec 03 00:00:00 UTC 2015
Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation.
Scientific reports
Bächle SM,Sauter D,Sibitz S,Sandberg JK,Kirchhoff F,Moll M
Wed Apr 15 00:00:00 UTC 2015
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Cancer cell
Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E
Mon May 12 00:00:00 UTC 2014
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Blood
Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE
Thu Oct 02 00:00:00 UTC 2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.
Blood
Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK
Thu Feb 20 00:00:00 UTC 2014
Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages.
Blood
Nagelkerke SQ,Dekkers G,Kustiawan I,van de Bovenkamp FS,Geissler J,Plomp R,Wuhrer M,Vidarsson G,Rispens T,van den Berg TK,Kuijpers TW
Thu Dec 11 00:00:00 UTC 2014
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 UTC 2014
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
The Journal of clinical investigation
Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL
Wed Jan 01 00:00:00 UTC 2014
Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.
The Journal of experimental medicine
Williams GR,Fierens K,Preston SG,Lunn D,Rysnik O,De Prijck S,Kool M,Buckley HC,Lambrecht BN,O'Hare D,Austyn JM
Mon Jun 02 00:00:00 UTC 2014
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
The Journal of experimental medicine
Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE
Mon Apr 07 00:00:00 UTC 2014
Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication.
Proceedings of the National Academy of Sciences of the United States of America
Guo Z,Tilburgs T,Wong B,Strominger JL
Tue Sep 30 00:00:00 UTC 2014
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
Proceedings of the National Academy of Sciences of the United States of America
Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M
Tue Oct 14 00:00:00 UTC 2014
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
Cell death and differentiation
Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW
Wed Jan 01 00:00:00 UTC 2014
Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy.
British journal of cancer
Tazzari M,Negri T,Rini F,Vergani B,Huber V,Villa A,Dagrada P,Colombo C,Fiore M,Gronchi A,Stacchiotti S,Casali PG,Pilotti S,Rivoltini L,Castelli C
Tue Sep 23 00:00:00 UTC 2014
ABCG1-mediated generation of extracellular cholesterol microdomains.
Journal of lipid research
Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS
Wed Jan 01 00:00:00 UTC 2014
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
Stem cells (Dayton, Ohio)
Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM
Mon Dec 01 00:00:00 UTC 2014
Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Yu J,Wang Y,Yan F,Zhang P,Li H,Zhao H,Yan C,Yan F,Ren X
Mon Sep 01 00:00:00 UTC 2014
Activin A as a mediator of NK-dendritic cell functional interactions.
Journal of immunology (Baltimore, Md. : 1950)
Seeger P,Bosisio D,Parolini S,Badolato R,Gismondi A,Santoni A,Sozzani S
Sat Feb 01 00:00:00 UTC 2014
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M
Fri Aug 15 00:00:00 UTC 2014
Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.
Journal of immunology (Baltimore, Md. : 1950)
Madan-Lala R,Sia JK,King R,Adekambi T,Monin L,Khader SA,Pulendran B,Rengarajan J
Thu May 01 00:00:00 UTC 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
Tue Apr 15 00:00:00 UTC 2014
Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kawasaki N,Rillahan CD,Cheng TY,Van Rhijn I,Macauley MS,Moody DB,Paulson JC
Fri Aug 15 00:00:00 UTC 2014
IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
Journal of immunology (Baltimore, Md. : 1950)
Morandi F,Di Carlo E,Ferrone S,Petretto A,Pistoia V,Airoldi I
Sat Mar 15 00:00:00 UTC 2014
Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.
Journal of immunology (Baltimore, Md. : 1950)
Kis-Toth K,Tsokos GC
Thu May 01 00:00:00 UTC 2014
Human dendritic cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction.
Journal of immunology (Baltimore, Md. : 1950)
Favila MA,Geraci NS,Zeng E,Harker B,Condon D,Cotton RN,Jayakumar A,Tripathi V,McDowell MA
Sun Jun 15 00:00:00 UTC 2014
Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.
Journal of immunology (Baltimore, Md. : 1950)
Burgon J,Robertson AL,Sadiku P,Wang X,Hooper-Greenhill E,Prince LR,Walker P,Hoggett EE,Ward JR,Farrow SN,Zuercher WJ,Jeffrey P,Savage CO,Ingham PW,Hurlstone AF,Whyte MK,Renshaw SA
Sat Feb 15 00:00:00 UTC 2014
Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Ishii N,Funami K,Tatematsu M,Seya T,Matsumoto M
Sat Nov 15 00:00:00 UTC 2014
IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.
Journal of immunology (Baltimore, Md. : 1950)
Cao Y,Zhang R,Zhang W,Zhu C,Yu Y,Song Y,Wang Q,Bai L,Liu Y,Wu K,Wu J
Wed Jan 15 00:00:00 UTC 2014
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.
Journal of immunology (Baltimore, Md. : 1950)
Colak E,Leslie A,Zausmer K,Khatamzas E,Kubarenko AV,Pichulik T,Klimosch SN,Mayer A,Siggs O,Hector A,Fischer R,Klesser B,Rautanen A,Frank M,Hill AV,Manoury B,Beutler B,Hartl D,Simmons A,Weber AN
Sun Jun 15 00:00:00 UTC 2014
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
The Journal of biological chemistry
Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H
Fri Mar 21 00:00:00 UTC 2014
Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.
The Journal of biological chemistry
Shao Z,Morser J,Leung LLK
Fri Sep 26 00:00:00 UTC 2014
Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.
Cell death & disease
Hashimoto M,Nasser H,Chihara T,Suzu S
Thu May 29 00:00:00 UTC 2014
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 UTC 2014
Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.
The Journal of biological chemistry
Ishida A,Akita K,Mori Y,Tanida S,Toda M,Inoue M,Nakada H
Fri Sep 05 00:00:00 UTC 2014
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Nature
Kane M,Yadav SS,Bitzegeio J,Kutluay SB,Zang T,Wilson SJ,Schoggins JW,Rice CM,Yamashita M,Hatziioannou T,Bieniasz PD
Thu Oct 24 00:00:00 UTC 2013
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.
Immunity
Brain O,Owens BM,Pichulik T,Allan P,Khatamzas E,Leslie A,Steevels T,Sharma S,Mayer A,Catuneanu AM,Morton V,Sun MY,Jewell D,Coccia M,Harrison O,Maloy K,Schönefeldt S,Bornschein S,Liston A,Simmons A
Thu Sep 19 00:00:00 UTC 2013
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
Blood
Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S
Thu Feb 28 00:00:00 UTC 2013
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 UTC 2013
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
Kung Sutherland MS,Walter RB,Jeffrey SC,Burke PJ,Yu C,Kostner H,Stone I,Ryan MC,Sussman D,Lyon RP,Zeng W,Harrington KH,Klussman K,Westendorf L,Meyer D,Bernstein ID,Senter PD,Benjamin DR,Drachman JG,McEarchern JA
Thu Aug 22 00:00:00 UTC 2013
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.
Blood
Mussai F,De Santo C,Abu-Dayyeh I,Booth S,Quek L,McEwen-Smith RM,Qureshi A,Dazzi F,Vyas P,Cerundolo V
Thu Aug 01 00:00:00 UTC 2013
Regulation of dendritic cell activation by microRNA let-7c and BLIMP1.
The Journal of clinical investigation
Kim SJ,Gregersen PK,Diamond B
Fri Feb 01 00:00:00 UTC 2013
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.
The Journal of experimental medicine
Cohn L,Chatterjee B,Esselborn F,Smed-Sörensen A,Nakamura N,Chalouni C,Lee BC,Vandlen R,Keler T,Lauer P,Brockstedt D,Mellman I,Delamarre L
Mon May 06 00:00:00 UTC 2013
Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.
Proceedings of the National Academy of Sciences of the United States of America
Barber JS,Yokomizo LK,Sheikh V,Freeman AF,Garabedian E,van Dijk E,Sokolic R,Candotti F,Weng NP,Sereti I,Milner JD
Tue May 14 00:00:00 UTC 2013
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.
Proceedings of the National Academy of Sciences of the United States of America
Yamaguchi T,Kishi A,Osaki M,Morikawa H,Prieto-Martin P,Wing K,Saito T,Sakaguchi S
Tue Jun 04 00:00:00 UTC 2013
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation.
Proceedings of the National Academy of Sciences of the United States of America
Kawasaki N,Vela JL,Nycholat CM,Rademacher C,Khurana A,van Rooijen N,Crocker PR,Kronenberg M,Paulson JC
Tue May 07 00:00:00 UTC 2013
An upstream open reading frame modulates ebola virus polymerase translation and virus replication.
PLoS pathogens
Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF
Tue Jan 01 00:00:00 UTC 2013
E-cadherin interactions are required for Langerhans cell differentiation.
European journal of immunology
Mayumi N,Watanabe E,Norose Y,Watari E,Kawana S,Geijtenbeek TB,Takahashi H
Tue Jan 01 00:00:00 UTC 2013
Technical advance. Measurement of iNKT cell responses at the single-cell level against rare HIV-1-infected dendritic cells in a mixed culture.
Journal of leukocyte biology
Andersson SK,Paquin-Proulx D,Kroll M,Sandberg JK,Moll M
Fri Mar 01 00:00:00 UTC 2013
Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.
Journal of immunology (Baltimore, Md. : 1950)
Seow V,Lim J,Iyer A,Suen JY,Ariffin JK,Hohenhaus DM,Sweet MJ,Fairlie DP
Tue Oct 15 00:00:00 UTC 2013
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M
Wed May 01 00:00:00 UTC 2013
IFN-α induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mohanram V,Sköld AE,Bächle SM,Pathak SK,Spetz AL
Mon Apr 01 00:00:00 UTC 2013
Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.
Journal of immunology (Baltimore, Md. : 1950)
Sandgren KJ,Smed-Sörensen A,Forsell MN,Soldemo M,Adams WC,Liang F,Perbeck L,Koup RA,Wyatt RT,Karlsson Hedestam GB,Loré K
Mon Jul 01 00:00:00 UTC 2013
Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.
Journal of immunology (Baltimore, Md. : 1950)
Chen HW,Chen HY,Wang LT,Wang FH,Fang LW,Lai HY,Chen HH,Lu J,Hung MS,Cheng Y,Chen MY,Liu SJ,Chong P,Lee OK,Hsu SC
Wed May 15 00:00:00 UTC 2013
The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
Journal of immunology (Baltimore, Md. : 1950)
Mimura K,Shiraishi K,Mueller A,Izawa S,Kua LF,So J,Yong WP,Fujii H,Seliger B,Kiessling R,Kono K
Sun Dec 15 00:00:00 UTC 2013
The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang Q,Franks HA,Lax SJ,El Refaee M,Malecka A,Shah S,Spendlove I,Gough MJ,Seedhouse C,Madhusudan S,Patel PM,Jackson AM
Mon Apr 01 00:00:00 UTC 2013
IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Cohen PL
Wed May 15 00:00:00 UTC 2013
Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Seshadri C,Turner MT,Lewinsohn DM,Moody DB,Van Rhijn I
Tue Jan 01 00:00:00 UTC 2013
IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Vallières F,Girard D
Fri Mar 15 00:00:00 UTC 2013
Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Kahlenberg JM,Carmona-Rivera C,Smith CK,Kaplan MJ
Fri Feb 01 00:00:00 UTC 2013
Involvement of placental/umbilical cord blood acid-base status and gas values on the radiosensitivity of human fetal/neonatal hematopoietic stem/progenitor cells.
Journal of radiation research
Yamaguchi M,Ebina S,Kashiwakura I
Fri Mar 01 00:00:00 UTC 2013
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one
Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M
Fri Sep 27 00:00:00 UTC 2013
Chemoresistance of human monocyte-derived dendritic cells is regulated by IL-17A.
PloS one
Olsson Åkefeldt S,Maisse C,Belot A,Mazzorana M,Salvatore G,Bissay N,Jurdic P,Aricò M,Rabourdin-Combe C,Henter JI,Delprat C
Tue Aug 13 00:00:00 UTC 2013
Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.
Scientific reports
Kakazu E,Kondo Y,Kogure T,Ninomiya M,Kimura O,Ueno Y,Shimosegawa T
Tue Dec 10 00:00:00 UTC 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 UTC 2013
Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
PloS one
Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR
Tue Jul 09 00:00:00 UTC 2013
Leptin inhibits neutrophil apoptosis in children via ERK/NF-κB-dependent pathways.
PloS one
Sun Z,Dragon S,Becker A,Gounni AS
Mon Jul 22 00:00:00 UTC 2013
Differential activity of type I interferon subtypes for dendritic cell differentiation.
PloS one
Garcin G,Bordat Y,Chuchana P,Monneron D,Law HK,Piehler J,Uzé G
Tue Dec 03 00:00:00 UTC 2013
Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.
PloS one
Yu Q,Chow EM,McCaw SE,Hu N,Byrd D,Amet T,Hu S,Ostrowski MA,Gray-Owen SD
Thu Aug 08 00:00:00 UTC 2013
Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.
PloS one
Basso D,Fogar P,Falconi M,Fadi E,Sperti C,Frasson C,Greco E,Tamburrino D,Teolato S,Moz S,Bozzato D,Pelloso M,Padoan A,De Franchis G,Gnatta E,Facco M,Zambon CF,Navaglia F,Pasquali C,Basso G,Semenzato G,Pedrazzoli S,Pederzoli P,Plebani M
Fri Sep 06 00:00:00 UTC 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 UTC 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 UTC 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 UTC 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 UTC 2013
High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes.
PloS one
Currao M,Balduini CL,Balduini A
Fri Sep 06 00:00:00 UTC 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 UTC 2013
Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques.
Blood
Sköld AE,Hasan M,Vargas L,Saidi H,Bosquet N,Le Grand R,Smith CI,Spetz AL
Thu Jul 26 00:00:00 UTC 2012
Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells.
Blood
Toubai T,Tawara I,Sun Y,Liu C,Nieves E,Evers R,Friedman T,Korngold R,Reddy P
Thu Apr 19 00:00:00 UTC 2012
DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.
Blood
Hosszu KK,Valentino A,Vinayagasundaram U,Vinayagasundaram R,Joyce MG,Ji Y,Peerschke EI,Ghebrehiwet B
Thu Aug 09 00:00:00 UTC 2012
IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.
Blood
Spadaro F,Lapenta C,Donati S,Abalsamo L,Barnaba V,Belardelli F,Santini SM,Ferrantini M
Thu Feb 09 00:00:00 UTC 2012
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
Blood
Hutter C,Kauer M,Simonitsch-Klupp I,Jug G,Schwentner R,Leitner J,Bock P,Steinberger P,Bauer W,Carlesso N,Minkov M,Gadner H,Stingl G,Kovar H,Kriehuber E
Thu Dec 20 00:00:00 UTC 2012
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.
The Journal of experimental medicine
Junker Y,Zeissig S,Kim SJ,Barisani D,Wieser H,Leffler DA,Zevallos V,Libermann TA,Dillon S,Freitag TL,Kelly CP,Schuppan D
Mon Dec 17 00:00:00 UTC 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 UTC 2012
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.
The Journal of experimental medicine
Chu CC,Ali N,Karagiannis P,Di Meglio P,Skowera A,Napolitano L,Barinaga G,Grys K,Sharif-Paghaleh E,Karagiannis SN,Peakman M,Lombardi G,Nestle FO
Mon May 07 00:00:00 UTC 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 UTC 2012
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.
Autophagy
Phadwal K,Alegre-Abarrategui J,Watson AS,Pike L,Anbalagan S,Hammond EM,Wade-Martins R,McMichael A,Klenerman P,Simon AK
Sun Apr 01 00:00:00 UTC 2012
Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling.
Proceedings of the National Academy of Sciences of the United States of America
Sadik CD,Kim ND,Iwakura Y,Luster AD
Tue Nov 13 00:00:00 UTC 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 UTC 2012
C1q limits dendritic cell differentiation and activation by engaging LAIR-1.
Proceedings of the National Academy of Sciences of the United States of America
Son M,Santiago-Schwarz F,Al-Abed Y,Diamond B
Tue Nov 13 00:00:00 UTC 2012
Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Proceedings of the National Academy of Sciences of the United States of America
Ashraf SQ,Nicholls AM,Wilding JL,Ntouroupi TG,Mortensen NJ,Bodmer WF
Tue Dec 18 00:00:00 UTC 2012
Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia.
Journal of clinical immunology
Liu Y,Wu Y,Lam KT,Lee PP,Tu W,Lau YL
Fri Jun 01 00:00:00 UTC 2012
Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.
PLoS pathogens
Skyberg JA,Rollins MF,Holderness JS,Marlenee NL,Schepetkin IA,Goodyear A,Dow SW,Jutila MA,Pascual DW
Mon Jul 09 00:00:00 UTC 2012
DENV inhibits type I IFN production in infected cells by cleaving human STING.
PLoS pathogens
Aguirre S,Maestre AM,Pagni S,Patel JR,Savage T,Gutman D,Maringer K,Bernal-Rubio D,Shabman RS,Simon V,Rodriguez-Madoz JR,Mulder LC,Barber GN,Fernandez-Sesma A
Thu Apr 04 00:00:00 UTC 2013
GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.
PLoS pathogens
Fuks JM,Arrighi RB,Weidner JM,Kumar Mendu S,Jin Z,Wallin RP,Rethi B,Birnir B,Barragan A
Thu May 23 00:00:00 UTC 2013
Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells.
PLoS pathogens
Smed-Sörensen A,Chalouni C,Chatterjee B,Cohn L,Blattmann P,Nakamura N,Delamarre L,Mellman I
Mon Jul 09 00:00:00 UTC 2012
Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.
Arthritis research & therapy
Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE
Wed May 23 00:00:00 UTC 2012
Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.
Laboratory investigation; a journal of technical methods and pathology
Tsakiris I,Torocsik D,Gyongyosi A,Dozsa A,Szatmari I,Szanto A,Soos G,Nemes Z,Igali L,Marton I,Takats Z,Nagy L,Dezso B
Thu Mar 01 00:00:00 UTC 2012
Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura H,Kobayashi M,Wakita D,Nishimura T
Tue May 01 00:00:00 UTC 2012
Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells.
Journal of immunology (Baltimore, Md. : 1950)
Himoudi N,Morgenstern DA,Yan M,Vernay B,Saraiva L,Wu Y,Cohen CJ,Gustafsson K,Anderson J
Wed Feb 15 00:00:00 UTC 2012
Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Carrion J,Scisci E,Miles B,Sabino GJ,Zeituni AE,Gu Y,Bear A,Genco CA,Brown DL,Cutler CW
Sat Sep 15 00:00:00 UTC 2012
HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Chihara T,Hashimoto M,Osman A,Hiyoshi-Yoshidomi Y,Suzu I,Chutiwitoonchai N,Hiyoshi M,Okada S,Suzu S
Sun Apr 15 00:00:00 UTC 2012
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Hilliard BA,Monestier M,Cohen PL
Mon Oct 01 00:00:00 UTC 2012
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM
Sat Dec 01 00:00:00 UTC 2012
Enhancing immunostimulatory function of human embryonic stem cell-derived dendritic cells by CD1d overexpression.
Journal of immunology (Baltimore, Md. : 1950)
Zeng J,Shahbazi M,Wu C,Toh HC,Wang S
Tue May 01 00:00:00 UTC 2012
Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Journal of immunology (Baltimore, Md. : 1950)
Gallo RM,Khan MA,Shi J,Kapur R,Wei L,Bailey JC,Liu J,Brutkiewicz RR
Wed Aug 15 00:00:00 UTC 2012
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Zhang T,Wu MR,Sentman CL
Sat Sep 01 00:00:00 UTC 2012
Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Driessen NN,Boshoff HI,Maaskant JJ,Gilissen SA,Vink S,van der Sar AM,Vandenbroucke-Grauls CM,Bewley CA,Appelmelk BJ,Geurtsen J
Mon Oct 01 00:00:00 UTC 2012
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Saito Y,Kunisawa J,Kurashima Y,Wake T,Suzuki N,Shultz LD,Kiyono H,Ishikawa F
Fri Jun 15 00:00:00 UTC 2012
Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan A,Ma J,Kyme P,Wolf AJ,Becker CA,Tseng CW,Liu GY,Underhill DM
Thu Nov 01 00:00:00 UTC 2012
Activation of human neutrophils by the anti-inflammatory mediator Esenbeckia leiocarpa leads to atypical apoptosis.
Mediators of inflammation
de Liz R,Horst H,Pizzolatti MG,Fröde TS,Girard D
Wed Sep 26 00:00:00 UTC 2012
Elevated circulating interleukin-27 in patients with coronary artery disease is associated with dendritic cells, oxidized low-density lipoprotein, and severity of coronary artery stenosis.
Mediators of inflammation
Jin W,Zhao Y,Yan W,Cao L,Zhang W,Wang M,Zhang T,Fu Q,Li Z
Wed Nov 28 00:00:00 UTC 2012
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Gene therapy
Silk KM,Silk JD,Ichiryu N,Davies TJ,Nolan KF,Leishman AJ,Carpenter L,Watt SM,Cerundolo V,Fairchild PJ
Mon Oct 01 00:00:00 UTC 2012
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity.
Aging
Agrawal A,Su H,Chen J,Osann K,Agrawal S,Gupta S
Sat Sep 01 00:00:00 UTC 2012
Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe.
Scientific reports
Dufton N,Natividad J,Verdu EF,Wallace JL
Sun Mar 17 00:00:00 UTC 2013
Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment.
PloS one
Li CY,Chiang CS,Cheng WC,Wang SC,Cheng HT,Chen CR,Shu WY,Tsai ML,Hseu RS,Chang CW,Huang CY,Fang SH,Hsu IC
Fri Dec 07 00:00:00 UTC 2012
Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.
Blood cancer journal
Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S
Fri Jun 01 00:00:00 UTC 2012
Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.
PloS one
Dolganiuc A,Kodys K,Marshall C,Saha B,Zhang S,Bala S,Szabo G
Tue Apr 02 00:00:00 UTC 2013
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 UTC 2013
Enhancement of myeloma development mediated though myeloma cell-Th2 cell interactions after microbial antigen presentation by myeloma cells and DCs.
Blood cancer journal
Tian F,Li J,Li Y,Luo S
Fri Jun 01 00:00:00 UTC 2012
Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors.
The Journal of biological chemistry
Comas-Casellas E,Martínez-Barriocanal Á,Miró F,Ejarque-Ortiz A,Schwartz S,Martín M,Sayós J
Fri Mar 23 00:00:00 UTC 2012
Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.
PloS one
Benhamron S,Reiner I,Zcharia E,Atallah M,Grau A,Vlodavsky I,Mevorach D
Wed Sep 19 00:00:00 UTC 2012
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 UTC 2012
TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.
Clinical & developmental immunology
Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R
Fri Mar 01 00:00:00 UTC 2013
Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.
Scientific reports
Cobos Jiménez V,Booiman T,de Taeye SW,van Dort KA,Rits MA,Hamann J,Kootstra NA
Thu Mar 21 00:00:00 UTC 2013
IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
The Journal of biological chemistry
Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H
Fri Dec 07 00:00:00 UTC 2012
Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.
PloS one
Hoeve MA,Nash AA,Jackson D,Randall RE,Dransfield I
Mon May 14 00:00:00 UTC 2012
Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway.
The Journal of biological chemistry
Lee CL,Lam EY,Lam KK,Koistinen H,Seppälä M,Ng EH,Yeung WS,Chiu PC
Fri Oct 26 00:00:00 UTC 2012
Molecular mimics of the tumour antigen MUC1.
PloS one
James TC,Bond U
Thu Jun 20 00:00:00 UTC 2013
Genome-wide RNAi screen in IFN-γ-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis.
PloS one
Zhou H,DeLoid G,Browning E,Gregory DJ,Tan F,Bedugnis AS,Imrich A,Koziel H,Kramnik I,Lu Q,Kobzik L
Fri Aug 03 00:00:00 UTC 2012
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.
PloS one
Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R
Wed Apr 24 00:00:00 UTC 2013
Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.
Bone marrow research
Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O
Mon Oct 22 00:00:00 UTC 2012
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 UTC 2012
Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells.
PloS one
Mazurek J,Ignatowicz L,Kallenius G,Svenson SB,Pawlowski A,Hamasur B
Thu Jan 10 00:00:00 UTC 2013
Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.
The Journal of biological chemistry
Pathak SK,Sköld AE,Mohanram V,Persson C,Johansson U,Spetz AL
Fri Apr 20 00:00:00 UTC 2012
Rho GTPase expression in human myeloid cells.
PloS one
van Helden SF,Anthony EC,Dee R,Hordijk PL
Wed May 15 00:00:00 UTC 2013
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 UTC 2013
Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp.
PloS one
Prasad A,Kuzontkoski PM,Shrivastava A,Zhu W,Li DY,Groopman JE
Mon May 06 00:00:00 UTC 2013
IL-12 and GM-CSF in DNA/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and quality.
PloS one
Rodríguez AM,Pascutti MF,Maeto C,Falivene J,Holgado MP,Turk G,Gherardi MM
Thu Sep 27 00:00:00 UTC 2012
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.
Immunity
Chae JJ,Cho YH,Lee GS,Cheng J,Liu PP,Feigenbaum L,Katz SI,Kastner DL
Fri May 27 00:00:00 UTC 2011
Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.
Immunity
Mouchess ML,Arpaia N,Souza G,Barbalat R,Ewald SE,Lau L,Barton GM
Wed Nov 23 00:00:00 UTC 2011
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity
Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A
Fri Dec 23 00:00:00 UTC 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 UTC 2011
IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.
Blood
Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E
Thu Jun 16 00:00:00 UTC 2011
Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT.
Blood
Sivori S,Carlomagno S,Falco M,Romeo E,Moretta L,Moretta A
Thu Apr 21 00:00:00 UTC 2011
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Blood
Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L
Thu Mar 03 00:00:00 UTC 2011
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.
Blood
Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P
Thu Apr 14 00:00:00 UTC 2011
NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies.
Blood
Magri G,Muntasell A,Romo N,Sáez-Borderías A,Pende D,Geraghty DE,Hengel H,Angulo A,Moretta A,López-Botet M
Thu Jan 20 00:00:00 UTC 2011
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood
Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F
Thu Mar 17 00:00:00 UTC 2011
Monocytes from HTLV-1-infected patients are unable to fully mature into dendritic cells.
Blood
Nascimento CR,Lima MA,de Andrada Serpa MJ,Espindola O,Leite AC,Echevarria-Lima J
Thu Jan 13 00:00:00 UTC 2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Blood
Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R
Thu Apr 21 00:00:00 UTC 2011
Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML.
Blood
Du W,Li XE,Sipple J,Pang Q
Thu Apr 21 00:00:00 UTC 2011
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation.
The Journal of clinical investigation
Wu X,Gao H,Ke W,Giese RW,Zhu Z
Fri Jul 01 00:00:00 UTC 2011
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.
The Journal of experimental medicine
Séror C,Melki MT,Subra F,Raza SQ,Bras M,Saïdi H,Nardacci R,Voisin L,Paoletti A,Law F,Martins I,Amendola A,Abdul-Sater AA,Ciccosanti F,Delelis O,Niedergang F,Thierry S,Said-Sadier N,Lamaze C,Métivier D,Estaquier J,Fimia GM,Falasca L,Casetti R,Modjtahedi N,Kanellopoulos J,Mouscadet JF,Ojcius DM,Piacentini M,Gougeon ML,Kroemer G,Perfettini JL
Mon Aug 29 00:00:00 UTC 2011
In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates.
The Journal of experimental medicine
Jung KC,Park CG,Jeon YK,Park HJ,Ban YL,Min HS,Kim EJ,Kim JH,Kang BH,Park SP,Bae Y,Yoon IH,Kim YH,Lee JI,Kim JS,Shin JS,Yang J,Kim SJ,Rostlund E,Muller WA,Park SH
Mon Nov 21 00:00:00 UTC 2011
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.
The Journal of experimental medicine
Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Nonoyama S,Karasuyama H,Minegishi Y
Mon Feb 14 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.
PLoS biology
Palendira U,Low C,Chan A,Hislop AD,Ho E,Phan TG,Deenick E,Cook MC,Riminton DS,Choo S,Loh R,Alvaro F,Booth C,Gaspar HB,Moretta A,Khanna R,Rickinson AB,Tangye SG
Tue Nov 01 00:00:00 UTC 2011
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.
PLoS pathogens
Varga ZT,Ramos I,Hai R,Schmolke M,García-Sastre A,Fernandez-Sesma A,Palese P
Wed Jun 01 00:00:00 UTC 2011
Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.
PLoS pathogens
Portevin D,Gagneux S,Comas I,Young D
Tue Mar 01 00:00:00 UTC 2011
Effects of receptor binding specificity of avian influenza virus on the human innate immune response.
Journal of virology
Ramos I,Bernal-Rubio D,Durham N,Belicha-Villanueva A,Lowen AC,Steel J,Fernandez-Sesma A
Sun May 01 00:00:00 UTC 2011
Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms.
Stem cells (Dayton, Ohio)
Su WR,Zhang QZ,Shi SH,Nguyen AL,Le AD
Tue Nov 01 00:00:00 UTC 2011
Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kolli D,Bao X,Liu T,Hong C,Wang T,Garofalo RP,Casola A
Fri Jul 01 00:00:00 UTC 2011
Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Fragale A,Stellacci E,Ilari R,Remoli AL,Lanciotti A,Perrotti E,Shytaj I,Orsatti R,Lawrence HR,Lawrence NJ,Wu J,Rehli M,Ozato K,Battistini A
Tue Feb 15 00:00:00 UTC 2011
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors.
Journal of immunology (Baltimore, Md. : 1950)
Iwata-Kajihara T,Sumimoto H,Kawamura N,Ueda R,Takahashi T,Mizuguchi H,Miyagishi M,Takeda K,Kawakami Y
Fri Jul 01 00:00:00 UTC 2011
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J
Sat Oct 01 00:00:00 UTC 2011
Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Simard JC,Simon MM,Tessier PA,Girard D
Tue Mar 15 00:00:00 UTC 2011
Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Young TW,Straub C,Stafford S,Kurosky A
Wed Jun 01 00:00:00 UTC 2011
IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis.
Journal of immunology (Baltimore, Md. : 1950)
Bauler TJ,Chase JC,Bosio CM
Mon Aug 15 00:00:00 UTC 2011
Thymic stromal lymphopoietin is produced by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ
Mon Aug 01 00:00:00 UTC 2011
Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K
Tue Feb 01 00:00:00 UTC 2011
Pulmonary collectins play distinct roles in host defense against Mycobacterium avium.
Journal of immunology (Baltimore, Md. : 1950)
Ariki S,Kojima T,Gasa S,Saito A,Nishitani C,Takahashi M,Shimizu T,Kurimura Y,Sawada N,Fujii N,Kuroki Y
Thu Sep 01 00:00:00 UTC 2011
Platelet-activating factor induces Th17 cell differentiation.
Mediators of inflammation
Drolet AM,Thivierge M,Turcotte S,Hanna D,Maynard B,Stankovà J,Rola-Pleszczynski M
Tue May 15 00:00:00 UTC 2012
The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
Cellular immunology
Hölzl MA,Hofer J,Kovarik JJ,Roggenbuck D,Reinhold D,Goihl A,Gärtner M,Steinberger P,Zlabinger GJ
Mon Apr 18 00:00:00 UTC 2011
Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms.
Blood cancer journal
Rice KL,Lin X,Wolniak K,Ebert BL,Berkofsky-Fessler W,Buzzai M,Sun Y,Xi C,Elkin P,Levine R,Golub T,Gilliland DG,Crispino JD,Licht JD,Zhang W
Tue Nov 01 00:00:00 UTC 2011
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 UTC 2011
KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.
PloS one
Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P
Fri Dec 23 00:00:00 UTC 2011
Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers.
BMC complementary and alternative medicine
de Oliveira CC,Abud AP,de Oliveira SM,Guimarães Fde S,de Andrade LF,Di Bernardi RP,Coletto EL,Kuczera D,Da Lozzo EJ,Gonçalves JP,Trindade Eda S,Buchi Dde F
Wed Oct 26 00:00:00 UTC 2011
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.
PloS one
Zou Z,Chastain A,Moir S,Ford J,Trandem K,Martinelli E,Cicala C,Crocker P,Arthos J,Sun PD
Fri Jun 08 00:00:00 UTC 2012
Modulation of human immune responses by bovine interleukin-10.
PloS one
den Hartog G,Savelkoul HF,Schoemaker R,Tijhaar E,Westphal AH,de Ruiter T,van de Weg-Schrijver E,van Neerven RJ
Fri Mar 25 00:00:00 UTC 2011
Modulation of human immune responses by bovine interleukin-10.
PloS one
den Hartog G,Savelkoul HF,Schoemaker R,Tijhaar E,Westphal AH,de Ruiter T,van de Weg-Schrijver E,van Neerven RJ
Fri Mar 25 00:00:00 UTC 2011
Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells.
PloS one
Alen MM,De Burghgraeve T,Kaptein SJ,Balzarini J,Neyts J,Schols D
Thu Dec 01 00:00:00 UTC 2011
Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.
PloS one
Climent N,Guerra S,García F,Rovira C,Miralles L,Gómez CE,Piqué N,Gil C,Gatell JM,Esteban M,Gallart T
Mon Nov 28 00:00:00 UTC 2011
Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate.
Journal of translational medicine
Chiang CL,Maier DA,Kandalaft LE,Brennan AL,Lanitis E,Ye Q,Levine BL,Czerniecki BJ,Powell DJ,Coukos G
Mon Nov 14 00:00:00 UTC 2011
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
The Journal of biological chemistry
Watanabe A,Tatematsu M,Saeki K,Shibata S,Shime H,Yoshimura A,Obuse C,Seya T,Matsumoto M
Fri Mar 25 00:00:00 UTC 2011
Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs.
BMC immunology
Wang Y,Xiong X,Wu D,Wang X,Wen B
Sat Sep 03 00:00:00 UTC 2011
Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients.
PloS one
Lasigliè D,Traggiai E,Federici S,Alessio M,Buoncompagni A,Accogli A,Chiesa S,Penco F,Martini A,Gattorno M
Thu Sep 29 00:00:00 UTC 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 UTC 2011
Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.
The Journal of biological chemistry
Germain C,Meier A,Jensen T,Knapnougel P,Poupon G,Lazzari A,Neisig A,Håkansson K,Dong T,Wagtmann N,Galsgaard ED,Spee P,Braud VM
Fri Nov 04 00:00:00 UTC 2011
Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function.
BMC infectious diseases
Wu Y,Mao H,Ling MT,Chow KH,Ho PL,Tu W,Lau YL
Wed Jul 20 00:00:00 UTC 2011
Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.
Journal of neuroinflammation
Dao MA,Tate CC,Aizman I,McGrogan M,Case CC
Fri Oct 07 00:00:00 UTC 2011
Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.
PloS one
Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G
Mon Aug 27 00:00:00 UTC 2012
Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.
PloS one
Santini SM,Lapenta C,Donati S,Spadaro F,Belardelli F,Ferrantini M
Mon Feb 28 00:00:00 UTC 2011
Exposure to apoptotic activated CD4+ T cells induces maturation and APOBEC3G-mediated inhibition of HIV-1 infection in dendritic cells.
PloS one
Mohanram V,Johansson U,Sköld AE,Fink J,Kumar Pathak S,Mäkitalo B,Walther-Jallow L,Spetz AL
Mon Nov 07 00:00:00 UTC 2011
Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.
Journal of biological engineering
Tai A,Froelich S,Joo KI,Wang P
Fri Jan 28 00:00:00 UTC 2011
Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells.
Scientific reports
Harada Y,Okada-Nakanishi Y,Ueda Y,Tsujitani S,Saito S,Fuji-Ogawa T,Iida A,Hasegawa M,Ichikawa T,Yonemitsu Y
Tue Sep 10 00:00:00 UTC 2013
MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4.
The Journal of biological chemistry
Tserel L,Runnel T,Kisand K,Pihlap M,Bakhoff L,Kolde R,Peterson H,Vilo J,Peterson P,Rebane A
Fri Jul 29 00:00:00 UTC 2011
Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen.
Reproductive biology and endocrinology : RB&E
Escribese MM,Rodríguez-García M,Sperling R,Engel SM,Gallart T,Moran TM
Tue Aug 23 00:00:00 UTC 2011
CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
BMC immunology
Wang XB,Fan ZZ,Anton D,Vollenhoven AV,Ni ZH,Chen XF,Lefvert AK
Fri Mar 18 00:00:00 UTC 2011
Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide.
BMC immunology
Wang M,Zhang Y,Chen Y,Zhang L,Lu X,Chen Z
Sat Jan 01 00:00:00 UTC 2011
Lipoglycans contribute to innate immune detection of mycobacteria.
PloS one
Krishna S,Ray A,Dubey SK,Larrouy-Maumus G,Chalut C,Castanier R,Noguera A,Gilleron M,Puzo G,Vercellone A,Nampoothiri KM,Nigou J
Fri Jul 20 00:00:00 UTC 2012
Mature autologous dendritic cell vaccines in advanced non-small cell lung cancer: a phase I pilot study.
Journal of experimental & clinical cancer research : CR
Perroud MW,Honma HN,Barbeiro AS,Gilli SC,Almeida MT,Vassallo J,Saad ST,Zambon L
Fri Jun 17 00:00:00 UTC 2011
Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus.
PloS one
Johnson TR,Johnson CN,Corbett KS,Edwards GC,Graham BS
Fri Jan 28 00:00:00 UTC 2011
Evidence for a cross-talk between human neutrophils and Th17 cells.
Blood
Pelletier M,Maggi L,Micheletti A,Lazzeri E,Tamassia N,Costantini C,Cosmi L,Lunardi C,Annunziato F,Romagnani S,Cassatella MA
Thu Jan 14 00:00:00 UTC 2010
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.
Blood
Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD
Thu Oct 14 00:00:00 UTC 2010
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.
Blood
Racanelli V,Leone P,Frassanito MA,Brunetti C,Perosa F,Ferrone S,Dammacco F
Thu Feb 11 00:00:00 UTC 2010
Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.
Blood
Goh FG,Thomson SJ,Krausgruber T,Lanfrancotti A,Copley RR,Udalova IA
Thu Dec 16 00:00:00 UTC 2010
The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.
Blood
Van Handel B,Prashad SL,Hassanzadeh-Kiabi N,Huang A,Magnusson M,Atanassova B,Chen A,Hamalainen EI,Mikkola HK
Thu Oct 28 00:00:00 UTC 2010
Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
Blood
Valeri VW,Hryniewicz A,Andresen V,Jones K,Fenizia C,Bialuk I,Chung HK,Fukumoto R,Parks RW,Ferrari MG,Nicot C,Cecchinato V,Ruscetti F,Franchini G
Thu Nov 11 00:00:00 UTC 2010
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Blood
Tewary P,Yang D,de la Rosa G,Li Y,Finn MW,Krensky AM,Clayberger C,Oppenheim JJ
Thu Nov 04 00:00:00 UTC 2010
Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments.
Blood
Moll M,Andersson SK,Smed-Sörensen A,Sandberg JK
Thu Sep 16 00:00:00 UTC 2010
Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.
Blood
Guo PF,Du MR,Wu HX,Lin Y,Jin LP,Li DJ
Thu Sep 23 00:00:00 UTC 2010
IRF5 is required for late-phase TNF secretion by human dendritic cells.
Blood
Krausgruber T,Saliba D,Ryzhakov G,Lanfrancotti A,Blazek K,Udalova IA
Thu Jun 03 00:00:00 UTC 2010
Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
The Journal of clinical investigation
Kreindler JL,Steele C,Nguyen N,Chan YR,Pilewski JM,Alcorn JF,Vyas YM,Aujla SJ,Finelli P,Blanchard M,Zeigler SF,Logar A,Hartigan E,Kurs-Lasky M,Rockette H,Ray A,Kolls JK
Wed Sep 01 00:00:00 UTC 2010
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
The Journal of experimental medicine
Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H
Mon Nov 22 00:00:00 UTC 2010
Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.
The Journal of experimental medicine
Robinson RT,Khader SA,Martino CA,Fountain JJ,Teixeira-Coelho M,Pearl JE,Smiley ST,Winslow GM,Woodland DL,Walter MJ,Conejo-Garcia JR,Gubler U,Cooper AM
Mon Mar 15 00:00:00 UTC 2010
Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.
Proceedings of the National Academy of Sciences of the United States of America
Meuter S,Eberl M,Moser B
Tue May 11 00:00:00 UTC 2010
Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection.
Proceedings of the National Academy of Sciences of the United States of America
Takahashi K,Asabe S,Wieland S,Garaigorta U,Gastaminza P,Isogawa M,Chisari FV
Tue Apr 20 00:00:00 UTC 2010
Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells.
The Journal of investigative dermatology
Kagatani S,Sasaki Y,Hirota M,Mizuashi M,Suzuki M,Ohtani T,Itagaki H,Aiba S
Fri Jan 01 00:00:00 UTC 2010
Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.
PLoS pathogens
Tabouret G,Astarie-Dequeker C,Demangel C,Malaga W,Constant P,Ray A,Honoré N,Bello NF,Perez E,Daffé M,Guilhot C
Thu Oct 21 00:00:00 UTC 2010
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
PLoS pathogens
Hanley TM,Blay Puryear W,Gummuluru S,Viglianti GA
Thu Jul 01 00:00:00 UTC 2010
Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1.
PLoS pathogens
Melki MT,Saïdi H,Dufour A,Olivo-Marin JC,Gougeon ML
Thu Apr 15 00:00:00 UTC 2010
A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod.
PLoS pathogens
Neumann AK,Jacobson K
Fri Feb 12 00:00:00 UTC 2010
Antiviral response dictated by choreographed cascade of transcription factors.
Journal of immunology (Baltimore, Md. : 1950)
Zaslavsky E,Hershberg U,Seto J,Pham AM,Marquez S,Duke JL,Wetmur JG,Tenoever BR,Sealfon SC,Kleinstein SH
Mon Mar 15 00:00:00 UTC 2010
Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.
Journal of immunology (Baltimore, Md. : 1950)
Vossenkämper A,Marchès O,Fairclough PD,Warnes G,Stagg AJ,Lindsay JO,Evans PC,Luong le A,Croft NM,Naik S,Frankel G,MacDonald TT
Fri Oct 01 00:00:00 UTC 2010
The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Takao S,Ishikawa T,Yamashita K,Uchiyama T
Mon Nov 15 00:00:00 UTC 2010
Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
Esmann L,Idel C,Sarkar A,Hellberg L,Behnen M,Möller S,van Zandbergen G,Klinger M,Köhl J,Bussmeyer U,Solbach W,Laskay T
Fri Jan 01 00:00:00 UTC 2010
Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.
Journal of immunology (Baltimore, Md. : 1950)
Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J
Wed Dec 01 00:00:00 UTC 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 UTC 2010
Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils.
Journal of immunology (Baltimore, Md. : 1950)
Bates ME,Sedgwick JB,Zhu Y,Liu LY,Heuser RG,Jarjour NN,Kita H,Bertics PJ
Tue Jun 15 00:00:00 UTC 2010
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Hu J,Nistal-Villán E,Voho A,Ganee A,Kumar M,Ding Y,García-Sastre A,Wetmur JG
Thu Jul 01 00:00:00 UTC 2010
Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein.
Journal of immunology (Baltimore, Md. : 1950)
Mukai T,Maeda Y,Tamura T,Matsuoka M,Tsukamoto Y,Makino M
Mon Nov 15 00:00:00 UTC 2010
A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression.
Journal of immunology (Baltimore, Md. : 1950)
Liu J,Shaji D,Cho S,Du W,Gervay-Hague J,Brutkiewicz RR
Sat May 01 00:00:00 UTC 2010
Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Murphy AJ,Guyre PM,Pioli PA
Sat May 01 00:00:00 UTC 2010
A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,van den Bosch A,van der Kooij SW,Janssen HL,Coffer PJ,van Kooten C,Woltman AM
Wed Dec 15 00:00:00 UTC 2010
Transcription factor E2F1 suppresses dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Fang F,Wang Y,Li R,Zhao Y,Guo Y,Jiang M,Sun J,Ma Y,Ren Z,Tian Z,Wei F,Yang D,Xiao W
Tue Jun 01 00:00:00 UTC 2010
Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression.
Journal of immunology (Baltimore, Md. : 1950)
Semnani RT,Mahapatra L,Dembele B,Konate S,Metenou S,Dolo H,Coulibaly ME,Soumaoro L,Coulibaly SY,Sanogo D,Seriba Doumbia S,Diallo AA,Traoré SF,Klion A,Nutman TB,Mahanty S
Mon Nov 15 00:00:00 UTC 2010
Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis.
Journal of immunology (Baltimore, Md. : 1950)
Mittal R,Gonzalez-Gomez I,Prasadarao NV
Wed Sep 01 00:00:00 UTC 2010
Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Elsheikh A,Lavergne SN,Castrejon JL,Farrell J,Wang H,Sathish J,Pichler WJ,Park BK,Naisbitt DJ
Wed Dec 01 00:00:00 UTC 2010
Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.
The Journal of biological chemistry
Walseng E,Furuta K,Goldszmid RS,Weih KA,Sher A,Roche PA
Fri Dec 31 00:00:00 UTC 2010
Bifidobacterium animalis AHC7 protects against pathogen-induced NF-κB activation in vivo.
BMC immunology
O'Mahony D,Murphy S,Boileau T,Park J,O'Brien F,Groeger D,Konieczna P,Ziegler M,Scully P,Shanahan F,Kiely B,O'Mahony L
Wed Dec 22 00:00:00 UTC 2010
In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.
PloS one
Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR
Fri Aug 27 00:00:00 UTC 2010
Global analysis of circulating immune cells by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
PloS one
Ouedraogo R,Flaudrops C,Ben Amara A,Capo C,Raoult D,Mege JL
Wed Oct 27 00:00:00 UTC 2010
Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.
The Journal of biological chemistry
Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ
Fri Jul 02 00:00:00 UTC 2010
Age-associated epigenetic modifications in human DNA increase its immunogenicity.
Aging
Agrawal A,Tay J,Yang GE,Agrawal S,Gupta S
Sat Mar 20 00:00:00 UTC 2010
Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.
The Journal of biological chemistry
Mao AP,Li S,Zhong B,Li Y,Yan J,Li Q,Teng C,Shu HB
Fri Mar 26 00:00:00 UTC 2010
Characterization of alternatively spliced transcript variants of CLEC2D gene.
The Journal of biological chemistry
Germain C,Bihl F,Zahn S,Poupon G,Dumaurier MJ,Rampanarivo HH,Padkjær SB,Spee P,Braud VM
Fri Nov 12 00:00:00 UTC 2010
Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses.
PloS one
Agrawal S,Gupta S,Agrawal A
Mon Oct 18 00:00:00 UTC 2010
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.
BMC systems biology
Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A
Wed Jun 16 00:00:00 UTC 2010
Hypoxia modulates human eosinophil function.
Clinical and molecular allergy : CMA
Nissim Ben Efraim AH,Eliashar R,Levi-Schaffer F
Mon Jul 19 00:00:00 UTC 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 UTC 2010
Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells.
PloS one
Ochiel DO,Ochsenbauer C,Kappes JC,Ghosh M,Fahey JV,Wira CR
Tue Dec 14 00:00:00 UTC 2010
Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.
Journal of inflammation (London, England)
Jensen SS,Gad M
Tue Jul 27 00:00:00 UTC 2010
Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.
PloS one
Rodríguez-García M,Climent N,Oliva H,Casanova V,Franco R,Leon A,Gatell JM,García F,Gallart T
Thu Feb 25 00:00:00 UTC 2010
The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus.
PloS one
Ben-Zvi I,Aranow C,Mackay M,Stanevsky A,Kamen DL,Marinescu LM,Collins CE,Gilkeson GS,Diamond B,Hardin JA
Tue Feb 16 00:00:00 UTC 2010
Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment.
PLoS neglected tropical diseases
Donaghy L,Cabillic F,Corlu A,Rostan O,Toutirais O,Guguen-Guillouzo C,Guiguen C,Gangneux JP
Tue Jun 08 00:00:00 UTC 2010
ErythRED, a hESC line enabling identification of erythroid cells.
Nature methods
Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG
Tue Sep 01 00:00:00 UTC 2009
Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models.
Cell research
Pomper MG,Hammond H,Yu X,Ye Z,Foss CA,Lin DD,Fox JJ,Cheng L
Sun Mar 01 00:00:00 UTC 2009
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
Immunity
Zhong B,Zhang L,Lei C,Li Y,Mao AP,Yang Y,Wang YY,Zhang XL,Shu HB
Fri Mar 20 00:00:00 UTC 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 UTC 2009
NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.
Blood
Starnes LM,Sorrentino A,Pelosi E,Ballarino M,Morsilli O,Biffoni M,Santoro S,Felli N,Castelli G,De Marchis ML,Mastroberardino G,Gabbianelli M,Fatica A,Bozzoni I,Nervi C,Peschle C
Thu Aug 27 00:00:00 UTC 2009
HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1.
Blood
Anand AR,Prasad A,Bradley RR,Deol YS,Nagaraja T,Ren X,Terwilliger EF,Ganju RK
Thu Oct 22 00:00:00 UTC 2009
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.
Blood
Ding Y,Harada Y,Imagawa J,Kimura A,Harada H
Thu Dec 10 00:00:00 UTC 2009
Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption.
Blood
Chakravarti A,Raquil MA,Tessier P,Poubelle PE
Thu Aug 20 00:00:00 UTC 2009
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.
Blood
Spaggiari GM,Abdelrazik H,Becchetti F,Moretta L
Thu Jun 25 00:00:00 UTC 2009
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.
The Journal of experimental medicine
Iwakiri D,Zhou L,Samanta M,Matsumoto M,Ebihara T,Seya T,Imai S,Fujieda M,Kawa K,Takada K
Mon Sep 28 00:00:00 UTC 2009
Salmonella regulates polyubiquitination and surface expression of MHC class II antigens.
Proceedings of the National Academy of Sciences of the United States of America
Lapaque N,Hutchinson JL,Jones DC,Méresse S,Holden DW,Trowsdale J,Kelly AP
Tue Aug 18 00:00:00 UTC 2009
Identification of tumor-associated, MHC class II-restricted phosphopeptides as targets for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Depontieu FR,Qian J,Zarling AL,McMiller TL,Salay TM,Norris A,English AM,Shabanowitz J,Engelhard VH,Hunt DF,Topalian SL
Tue Jul 21 00:00:00 UTC 2009
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Proceedings of the National Academy of Sciences of the United States of America
Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH
Tue Oct 06 00:00:00 UTC 2009
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Ceppi M,Pereira PM,Dunand-Sauthier I,Barras E,Reith W,Santos MA,Pierre P
Tue Feb 24 00:00:00 UTC 2009
The role of transposable elements in the regulation of IFN-lambda1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America
Thomson SJ,Goh FG,Banks H,Krausgruber T,Kotenko SV,Foxwell BM,Udalova IA
Tue Jul 14 00:00:00 UTC 2009
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Brandes M,Willimann K,Bioley G,Lévy N,Eberl M,Luo M,Tampé R,Lévy F,Romero P,Moser B
Tue Feb 17 00:00:00 UTC 2009
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS biology
Fox LM,Cox DG,Lockridge JL,Wang X,Chen X,Scharf L,Trott DL,Ndonye RM,Veerapen N,Besra GS,Howell AR,Cook ME,Adams EJ,Hildebrand WH,Gumperz JE
Thu Oct 01 00:00:00 UTC 2009
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.
The Journal of cell biology
Chong HC,Tan MJ,Philippe V,Tan SH,Tan CK,Ku CW,Goh YY,Wahli W,Michalik L,Tan NS
Mon Mar 23 00:00:00 UTC 2009
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.
PLoS pathogens
Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B
Sun Feb 01 00:00:00 UTC 2009
Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy.
Cancer gene therapy
Tosch C,Geist M,Ledoux C,Ziller-Remi C,Paul S,Erbs P,Corvaia N,Von Hoegen P,Balloul JM,Haegel H
Wed Apr 01 00:00:00 UTC 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 UTC 2009
Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.
Laboratory investigation; a journal of technical methods and pathology
Chakravarti A,Rusu D,Flamand N,Borgeat P,Poubelle PE
Thu Oct 01 00:00:00 UTC 2009
Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.
Journal of immunology (Baltimore, Md. : 1950)
Mittal R,Bulgheresi S,Emami C,Prasadarao NV
Sun Nov 15 00:00:00 UTC 2009
Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.
Journal of immunology (Baltimore, Md. : 1950)
Geurtsen J,Chedammi S,Mesters J,Cot M,Driessen NN,Sambou T,Kakutani R,Ummels R,Maaskant J,Takata H,Baba O,Terashima T,Bovin N,Vandenbroucke-Grauls CM,Nigou J,Puzo G,Lemassu A,Daffé M,Appelmelk BJ
Thu Oct 15 00:00:00 UTC 2009
Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins.
Journal of immunology (Baltimore, Md. : 1950)
Thivierge M,Stankova J,Rola-Pleszczynski M
Sun Nov 15 00:00:00 UTC 2009
Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein.
Journal of immunology (Baltimore, Md. : 1950)
Mukai T,Maeda Y,Tamura T,Matsuoka M,Tsukamoto Y,Makino M
Sun Nov 15 00:00:00 UTC 2009
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.
Journal of immunology (Baltimore, Md. : 1950)
Chang BY,Zhao F,He X,Ren H,Braselmann S,Taylor V,Wicks J,Payan DG,Grossbard EB,Pine PR,Bullard DC
Sat Aug 01 00:00:00 UTC 2009
A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.
Journal of immunology (Baltimore, Md. : 1950)
Andersen CS,Agger EM,Rosenkrands I,Gomes JM,Bhowruth V,Gibson KJ,Petersen RV,Minnikin DE,Besra GS,Andersen P
Thu Jan 01 00:00:00 UTC 2009
Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Podgrabinska S,Kamalu O,Mayer L,Shimaoka M,Snoeck H,Randolph GJ,Skobe M
Sat Aug 01 00:00:00 UTC 2009
Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Scutera S,Fraone T,Musso T,Cappello P,Rossi S,Pierobon D,Orinska Z,Paus R,Bulfone-Paus S,Giovarelli M
Tue Sep 01 00:00:00 UTC 2009
Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion.
Journal of immunology (Baltimore, Md. : 1950)
Deuretzbacher A,Czymmeck N,Reimer R,Trülzsch K,Gaus K,Hohenberg H,Heesemann J,Aepfelbacher M,Ruckdeschel K
Sun Nov 01 00:00:00 UTC 2009
IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Goodman WA,Levine AD,Massari JV,Sugiyama H,McCormick TS,Cooper KD
Tue Sep 01 00:00:00 UTC 2009
Potent induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus.
Journal of immunology (Baltimore, Md. : 1950)
Santer DM,Yoshio T,Minota S,Möller T,Elkon KB
Thu Jan 15 00:00:00 UTC 2009
Dendritic cell anergy results from endotoxemia in severe malnutrition.
Journal of immunology (Baltimore, Md. : 1950)
Hughes SM,Amadi B,Mwiya M,Nkamba H,Tomkins A,Goldblatt D
Sat Aug 15 00:00:00 UTC 2009
Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Douagi I,Gujer C,Sundling C,Adams WC,Smed-Sörensen A,Seder RA,Karlsson Hedestam GB,Loré K
Sun Feb 15 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.
Journal of immunology (Baltimore, Md. : 1950)
Qu C,Nguyen VA,Merad M,Randolph GJ
Sun Mar 15 00:00:00 UTC 2009
Developmental switch of the expression of ion channels in human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G
Thu Oct 01 00:00:00 UTC 2009
IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M
Thu Jan 15 00:00:00 UTC 2009
The Toxoplasma gondii-shuttling function of dendritic cells is linked to the parasite genotype.
Infection and immunity
Lambert H,Vutova PP,Adams WC,Loré K,Barragan A
Wed Apr 01 00:00:00 UTC 2009
Anthrax edema toxin induces maturation of dendritic cells and enhances chemotaxis towards macrophage inflammatory protein 3beta.
Infection and immunity
Maldonado-Arocho FJ,Bradley KA
Fri May 01 00:00:00 UTC 2009
Short communication: Methamphetamine treatment increases in vitro and in vivo HIV replication.
AIDS research and human retroviruses
Toussi SS,Joseph A,Zheng JH,Dutta M,Santambrogio L,Goldstein H
Sun Nov 01 00:00:00 UTC 2009
Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy.
PloS one
Mileti E,Matteoli G,Iliev ID,Rescigno M
Wed Sep 16 00:00:00 UTC 2009
The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.
BMC immunology
Brown DP,Jones DC,Anderson KJ,Lapaque N,Buerki RA,Trowsdale J,Allen RL
Tue Oct 27 00:00:00 UTC 2009
Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.
Immunome research
Ceppi M,Clavarino G,Gatti E,Schmidt EK,de Gassart A,Blankenship D,Ogola G,Banchereau J,Chaussabel D,Pierre P
Fri Nov 27 00:00:00 UTC 2009
Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals.
PLoS neglected tropical diseases
Fujiwara RT,Cançado GG,Freitas PA,Santiago HC,Massara CL,Dos Santos Carvalho O,Corrêa-Oliveira R,Geiger SM,Bethony J
Mon Mar 08 00:00:00 UTC 2010
Thrombospondin-1-N-terminal domain induces a phagocytic state and thrombospondin-1-C-terminal domain induces a tolerizing phenotype in dendritic cells.
PloS one
Tabib A,Krispin A,Trahtemberg U,Verbovetski I,Lebendiker M,Danieli T,Mevorach D
Mon Aug 31 00:00:00 UTC 2009
Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.
PloS one
St-Onge M,Dumas A,Michaud A,Laflamme C,Dussault AA,Pouliot M
Thu May 14 00:00:00 UTC 2009
The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation.
PloS one
Gur-Wahnon D,Borovsky Z,Liebergall M,Rachmilewitz J
Mon Aug 31 00:00:00 UTC 2009
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Cancer cell
Kotecha N,Flores NJ,Irish JM,Simonds EF,Sakai DS,Archambeault S,Diaz-Flores E,Coram M,Shannon KM,Nolan GP,Loh ML
Tue Oct 07 00:00:00 UTC 2008
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Cancer cell
Kotecha N,Flores NJ,Irish JM,Simonds EF,Sakai DS,Archambeault S,Diaz-Flores E,Coram M,Shannon KM,Nolan GP,Loh ML
Tue Oct 07 00:00:00 UTC 2008
Estrogen inhibits dendritic cell maturation to RNA viruses.
Blood
Escribese MM,Kraus T,Rhee E,Fernandez-Sesma A,López CB,Moran TM
Mon Dec 01 00:00:00 UTC 2008
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation
De Santo C,Salio M,Masri SH,Lee LY,Dong T,Speak AO,Porubsky S,Booth S,Veerapen N,Besra GS,Gröne HJ,Platt FM,Zambon M,Cerundolo V
Mon Dec 01 00:00:00 UTC 2008
Induction of both CD8+ and CD4+ T-cell-mediated responses in colorectal cancer patients by colon antigen-1.
Clinical cancer research : an official journal of the American Association for Cancer Research
Maccalli C,Di Cristanziano V,Fodale V,Corsi D,D'Agostino G,Petrangeli V,Laurenti L,Guida S,Mazzocchi A,Arienti F,Perrone MP,Castelli C,Rivoltini L,Zagonel V,Tartaglia M,Parmiani G,Belardelli F
Sat Nov 15 00:00:00 UTC 2008
Preclinical characterization of SGN-70, a humanized antibody directed against CD70.
Clinical cancer research : an official journal of the American Association for Cancer Research
McEarchern JA,Smith LM,McDonagh CF,Klussman K,Gordon KA,Morris-Tilden CA,Duniho S,Ryan M,Boursalian TE,Carter PJ,Grewal IS,Law CL
Mon Dec 01 00:00:00 UTC 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 UTC 2008
Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus.
PLoS pathogens
Phipps-Yonas H,Seto J,Sealfon SC,Moran TM,Fernandez-Sesma A
Wed Oct 01 00:00:00 UTC 2008
Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus.
Arthritis research & therapy
Monrad SU,Rea K,Thacker S,Kaplan MJ
Fri Feb 20 00:00:00 UTC 2009
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.
Journal of immunology (Baltimore, Md. : 1950)
Itoh K,Watanabe A,Funami K,Seya T,Matsumoto M
Wed Oct 15 00:00:00 UTC 2008
Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.
Journal of immunology (Baltimore, Md. : 1950)
Semnani RT,Venugopal PG,Mahapatra L,Skinner JA,Meylan F,Chien D,Dorward DW,Chaussabel D,Siegel RM,Nutman TB
Sat Nov 15 00:00:00 UTC 2008
Lipoxin A4 counterregulates GM-CSF signaling in eosinophilic granulocytes.
Journal of immunology (Baltimore, Md. : 1950)
Starosta V,Pazdrak K,Boldogh I,Svider T,Kurosky A
Mon Dec 15 00:00:00 UTC 2008
Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.
Journal of immunology (Baltimore, Md. : 1950)
Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R
Mon Dec 15 00:00:00 UTC 2008
Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5.
Journal of immunology (Baltimore, Md. : 1950)
Gomez FJ,Pilcher-Roberts R,Alborzi A,Newman SL
Sat Nov 15 00:00:00 UTC 2008
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Journal of immunology (Baltimore, Md. : 1950)
Hartl D,Krauss-Etschmann S,Koller B,Hordijk PL,Kuijpers TW,Hoffmann F,Hector A,Eber E,Marcos V,Bittmann I,Eickelberg O,Griese M,Roos D
Mon Dec 01 00:00:00 UTC 2008
Antiviral-activated dendritic cells: a paracrine-induced response state.
Journal of immunology (Baltimore, Md. : 1950)
Bordería AV,Hartmann BM,Fernandez-Sesma A,Moran TM,Sealfon SC
Sat Nov 15 00:00:00 UTC 2008
Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia.
Journal of immunology (Baltimore, Md. : 1950)
Lambert C,Desbarats J,Arbour N,Hall JA,Olivier A,Bar-Or A,Antel JP
Mon Dec 15 00:00:00 UTC 2008
Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.
Human gene therapy
Theoret MR,Cohen CJ,Nahvi AV,Ngo LT,Suri KB,Powell DJ,Dudley ME,Morgan RA,Rosenberg SA
Sat Nov 01 00:00:00 UTC 2008
Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.
BMC immunology
Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A
Wed Oct 01 00:00:00 UTC 2008
HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk.
PloS one
Saïdi H,Melki MT,Gougeon ML
Thu Feb 12 00:00:00 UTC 2009
Direct contact of platelets and their released products exert different effects on human dendritic cell maturation.
BMC immunology
Hamzeh-Cognasse H,Cognasse F,Palle S,Chavarin P,Olivier T,Delézay O,Pozzetto B,Garraud O
Thu Sep 25 00:00:00 UTC 2008
Activin A induces Langerhans cell differentiation in vitro and in human skin explants.
PloS one
Musso T,Scutera S,Vermi W,Daniele R,Fornaro M,Castagnoli C,Alotto D,Ravanini M,Cambieri I,Salogni L,Elia AR,Giovarelli M,Facchetti F,Girolomoni G,Sozzani S
Wed Sep 24 00:00:00 UTC 2008
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Blood
Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K
Mon Oct 01 00:00:00 UTC 2007
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Cassatella MA,Pereira-da-Silva G,Tinazzi I,Facchetti F,Scapini P,Calzetti F,Tamassia N,Wei P,Nardelli B,Roschke V,Vecchi A,Mantovani A,Bambara LM,Edwards SW,Carletto A
Fri Jun 01 00:00:00 UTC 2007
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.
Blood
Della Chiesa M,Romagnani C,Thiel A,Moretta L,Moretta A
Fri Dec 01 00:00:00 UTC 2006
Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.
Blood
Mennechet FJ,Uzé G
Thu Jun 01 00:00:00 UTC 2006
Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.
Blood
Mennechet FJ,Uzé G
Thu Jun 01 00:00:00 UTC 2006
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 UTC 2006
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M
Wed Nov 01 00:00:00 UTC 2006
NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.
Blood
Vitale M,Della Chiesa M,Carlomagno S,Pende D,Aricò M,Moretta L,Moretta A
Fri Jul 15 00:00:00 UTC 2005
MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation.
The Journal of biological chemistry
Kim MS,Day CJ,Morrison NA
Fri Apr 22 00:00:00 UTC 2005
Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?
Blood
Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC
Wed Dec 15 00:00:00 UTC 2004
Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo.
Blood
Biragyn A,Ruffini PA,Coscia M,Harvey LK,Neelapu SS,Baskar S,Wang JM,Kwak LW
Fri Oct 01 00:00:00 UTC 2004
Studies of thiamine metabolism in man; thiamine and pyrimidine excretion with special reference to the relationship between injected and excreted thiamine in normal and abnormal subjects.
The Journal of clinical investigation
ALEXANDER B,LANDWEHR G,MITCHELL F
Wed May 01 00:00:00 UTC 1946
