Product References
Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation.
Cells
Purvis GSD,McNeill E,Wright B,Channon KM,Greaves DR
300-02 was used in In vitro experiments to investigate the origin and transcriptional reprogramming of monocytes using a model of acute inflammation, zymosan-induced peritonitis.
Sun May 26 00:00:00 UTC 2024
Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiao H,Du X,Tao Z,Jing N,Bao S,Gao WQ,Dong B,Fang YX
300-02 was used in In vitro experiments to indicate a reciprocal interaction between PCa cells and TAMs as a positive feedback-loop to repress ferroptosis in PCa, mediated by TAM-secreted taurine and tumor EV-delivered miR-181a-5p.
Mon Jan 01 00:00:00 UTC 2024
Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14.
Antioxidants (Basel, Switzerland)
Sanjurjo L,Castelblanco E,Julve J,Villalmanzo N,Téllez É,Ramirez-Morros A,Alonso N,Mauricio D,Sarrias MR
300-02 was used in In vitro experiments to support an enhanced synergistic pro-inflammatory effect induced by HG and oxLDL in cultured human macrophages, possibly explained by increased sCD14 shedding.
Thu May 11 00:00:00 UTC 2023
Early human lung immune cell development and its role in epithelial cell fate.
Science immunology
Barnes JL,Yoshida M,He P,Worlock KB,Lindeboom RGH,Suo C,Pett JP,Wilbrey-Clark A,Dann E,Mamanova L,Richardson L,Polanski K,Pennycuick A,Allen-Hyttinen J,Herczeg IT,Arzili R,Hynds RE,Teixeira VH,Haniffa M,Lim K,Sun D,Rawlins EL,Oliver AJ,Lyons PA,Marioni JC,Ruhrberg C,Tuong ZK,Clatworthy MR,Reading JL,Janes SM,Teichmann SA,Meyer KB,Nikolić MZ
300-02 was used in In vitro experiments to profile human embryonic and foetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry to find that IL-1β drives epithelial progenitor exit from self-renewal and differentiation to basal cells in vitro.
Fri Dec 15 00:00:00 UTC 2023
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.
The FEBS journal
Lockwood KC,Lear TB,Rajbhandari S,McKelvey AC,Dunn SR,Boudreau ÁN,Liu Y,Chen BB
300-02 was used in In vitro experiments to provide insight into the regulation of colonic inflammation through a new mechanism of ubiquitin-based control of SOCS1 protein.
Tue Aug 01 00:00:00 UTC 2023
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
Cancer immunology research
Lao L,Zeng W,Huang P,Chen H,Jia Z,Wang P,Huang D,Chen J,Nie Y,Yang L,Wu W,Liu J
300-02 was used in Cell Culture to identify a subset of CD161-overexpressing CD8+ T cells enriched in chemoresistant tumors. CD161 engagement repressed the calcium influx and cytolytic capacity of CD8+ T cells through acid sphingomyelinase activation and ceramide generation.
Wed Mar 01 00:00:00 UTC 2023
Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.
iScience
Hilliard S,Mosoyan K,Branciamore S,Gogoshin G,Zhang A,Simons DL,Rockne RC,Lee PP,Rodin AS
300-02 was used in In vitro experiments to propose that the ubiquitous information-theoretic principles underlying the development of artificial neural networks are similar to the principles guiding the macro-evolution of biological networks and that insights gained from one field can be applied to the other.
Fri Feb 17 00:00:00 UTC 2023
Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich's Ataxia Cells.
International journal of molecular sciences
Luffarelli R,Panarello L,Quatrana A,Tiano F,Fortuni S,Rufini A,Malisan F,Testi R,Condò I
300-02 was used in In vitro experiments to indicate the presence of multiple pathways triggered by IFN-γ with therapeutic relevance to FRDA.
Fri Aug 11 00:00:00 UTC 2023
Proteasome-dependent senescent tumor cells mediate immunosuppression through CCL20 secretion and M2 polarization in pancreatic ductal adenocarcinoma.
Frontiers in immunology
Wu M,Han J,Wu H,Liu Z
300-02 was used in In vitro experiments to identify senescence as a tumour-specific, hazardous factor associated with immunosuppression in pancreatic ductal adenocarcinoma.
Wed Jul 05 00:00:00 UTC 2023
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
300-02 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 UTC 2023
Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.
Cell death & disease
Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M
300-02 was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.
Tue Apr 04 00:00:00 UTC 2023
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.
Science advances
Riera-Domingo C,Leite-Gomes E,Charatsidou I,Zhao P,Carrá G,Cappellesso F,Mourao L,De Schepper M,Liu D,Serneels J,Alameh MG,Shuvaev VV,Geukens T,Isnaldi E,Prenen H,Weissman D,Muzykantov VR,Soenen S,Desmedt C,Scheele CLGJ,Sablina A,Di Matteo M,Martín-Pérez R,Mazzone M
300-02 was used in In vitro experiments to find that ECs at the PMN coexpress tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5).
Wed Mar 22 00:00:00 UTC 2023
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Molecular & cellular proteomics : MCP
Tshilenge KT,Aguirre CG,Bons J,Gerencser AA,Basisty N,Song S,Rose J,Lopez-Ramirez A,Naphade S,Loureiro A,Battistoni E,Milani M,Wehrfritz C,Holtz A,Hetz C,Mooney SD,Schilling B,Ellerby LM
300-02 was used in Cell Culture to define the proteome of human Huntington's disease patient-derived medium-spiny projection neurons.
Mon May 01 00:00:00 UTC 2023
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
300-02 was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 UTC 2022
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.
Proceedings of the National Academy of Sciences of the United States of America
Oreskovic E,Wheeler EC,Mengwasser KE,Fujimura E,Martin TD,Tothova Z,Elledge SJ
300-02 was used in Sample Preparation (Western Blotting) to investigate potential of CRISPR/Cas9 intervention of tumor suppressor genes on PD-L1 expression for IFN immune signaling.
Tue Feb 15 00:00:00 UTC 2022
Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants.
Genes & diseases
Hu C,Shen M,Han X,Chen Q,Li L,Chen S,Zhang J,Gao F,Wang W,Wang Y,Li T,Li S,Huang J,Wang J,Zhu J,Chen D,Wu Q,Tao K,Pang D,Jin A
Sat Jan 01 00:00:00 UTC 2022
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Immunology
Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O
Sun May 01 00:00:00 UTC 2022
Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages.
Journal of leukocyte biology
An L,Michaeli J,Pallavi P,Breedijk A,Xu X,Dietrich N,Sigl M,Keese M,Nitschke K,Jarczyk J,Nuhn P,Krämer BK,Yard BA,Leipe J
Thu Sep 01 00:00:00 UTC 2022
IFN-γ Induces IL-15 Trans-Presentation by Epithelial Cells via IRF1.
Journal of immunology (Baltimore, Md. : 1950)
Kim TS,Rha MS,Shin EC
Sat Jan 15 00:00:00 UTC 2022
Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy.
Cancer research and treatment
Chen Y,Huang H,Liu Y,Wang Z,Wang L,Wang Q,Zhang Y,Wang H
300-02 was used in Cell Culture to optimize a peptide (nABP284) that binds to PD-1 by a computer-based protocol in order to increase its affinity.
Fri Apr 01 00:00:00 UTC 2022
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Nature metabolism
Chen F,Elgaher WAM,Winterhoff M,Büssow K,Waqas FH,Graner E,Pires-Afonso Y,Casares Perez L,de la Vega L,Sahini N,Czichon L,Zobl W,Zillinger T,Shehata M,Pleschka S,Bähre H,Falk C,Michelucci A,Schuchardt S,Blankenfeldt W,Hirsch AKH,Pessler F
300-02 was used in In vitro experiments to show that itaconate is partially converted to mesaconate intracellularly and that mesaconate accumulation in macrophage activation depends on prior itaconate synthesis.
Sun May 01 00:00:00 UTC 2022
Effect of JAK Inhibition on the Induction of Proinflammatory HLA-DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ.
Arthritis & rheumatology (Hoboken, N.J.)
Zhao S,Grieshaber-Bouyer R,Rao DA,Kolb P,Chen H,Andreeva I,Tretter T,Lorenz HM,Watzl C,Wabnitz G,Tykocinski LO,Merkt W
300-02 was used in Cell Culture to investigate the generation, function and therapeutically intended blockage of HLA-DR+CD90+ synovial fibroblasts.
Tue Mar 01 00:00:00 UTC 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
300-02 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 UTC 2022
An integrated toolbox to profile macrophage immunometabolism.
Cell reports methods
Verberk SGS,de Goede KE,Gorki FS,van Dierendonck XAMH,Argüello RJ,Van den Bossche J
300-02 was used in Cell Culture to propose an application of SCENITH technology for ex vivo metabolic profiling.
Mon Apr 25 00:00:00 UTC 2022
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.
Cell reports
Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ
300-02 was used in Cell Culture to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.
Tue Jan 25 00:00:00 UTC 2022
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in immunology
Gopalakrishnan S,Hansen MD,Skovdahl HK,Roseth IA,van Beelen Granlund A,Østvik AE,Bakke I,Sandvik AK,Bruland T
300-02 was used in Cell Culture to identify a regulatory role for IBD-relevant pro-inflammatory signals on MHC-II expression that is influenced by Tofacitinib.
Mon Jun 06 00:00:00 UTC 2022
Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells.
mBio
Zuniga M,Gomes C,Chen Z,Martinez C,Devlin JC,Loke P,Rodriguez A
300-02 was used in Sample Preparation (FC/FACS) to investigate TNF-α regulation of cerebral malaria infection across the blood-brain barrier.
Wed Oct 26 00:00:00 UTC 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
300-02 was used in In vitro experiments to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 UTC 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
300-02 was used in In vitro experiments to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 UTC 2022
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology.
NAR cancer
Mall R,Bynigeri RR,Karki R,Malireddi RKS,Sharma BR,Kanneganti TD
300-02 was used in Cell Culture to identify and validated key innate immune biomarkers from PANoptosis which can be targeted to improve patient outcomes in cancers.
Thu Dec 01 00:00:00 UTC 2022
Tanreqing Injection Attenuates Macrophage Activation and the Inflammatory Response via the lncRNA-SNHG1/HMGB1 Axis in Lipopolysaccharide-Induced Acute Lung Injury.
Frontiers in immunology
Hu C,Li J,Tan Y,Liu Y,Bai C,Gao J,Zhao S,Yao M,Lu X,Qiu L,Xing L
300-02 was used in Cell Culture to investigate the pathogenesis and potential therapeutic targets of acute lung injury (ALI) and to define the target gene of Tanreqing (TRQ), which is a traditional Chinese medicine formula composed of five medicines, scutellaria baicalensis, bear bile powder, goat horn powder, honeysuckle and forsythia.
Tue May 17 00:00:00 UTC 2022
Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging.
Hepatology communications
Hernandez JC,Yeh DW,Marh J,Choi HY,Kim J,Chopra S,Ding L,Thornton M,Grubbs B,Makowka L,Sher L,Machida K
Fri Jul 01 00:00:00 UTC 2022
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.
Journal for immunotherapy of cancer
Wang H,Zhou Y,Zhang Y,Fang S,Zhang M,Li H,Xu F,Liu L,Liu J,Zhao Q,Wang F
300-02 was used in Cell Culture to reveal that pMMR/MSS CRC is immunogenically heterogeneous and that GBP2 is a promising target for combinatorial therapy with ICB.
Fri Apr 01 00:00:00 UTC 2022
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.
Journal for immunotherapy of cancer
Wang H,Zhou Y,Zhang Y,Fang S,Zhang M,Li H,Xu F,Liu L,Liu J,Zhao Q,Wang F
300-02 was used in Cell Culture to reveal that pMMR/MSS CRC is immunogenically heterogeneous and that GBP2 is a promising target for combinatorial therapy with ICB.
Fri Apr 01 00:00:00 UTC 2022
Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells.
Stem cell research & therapy
Song C,Wang L,Li Q,Liao B,Qiao W,Li Q,Dong N,Li L
300-02 was used in In vitro experiments to generate HLA-matched iPSCs based on patient's HLA genotyping by HLA exchanging approach to express the required HLA allele.
Wed Feb 02 00:00:00 UTC 2022
Three-Dimensional Bio-Printed Cardiac Patch for Sustained Delivery of Extracellular Vesicles from the Interface.
Gels (Basel, Switzerland)
Bar A,Kryukov O,Cohen S
300-02 was used in Cell Culture to propose a bi-functional, 3D bio-printed cardiac patch (CP) design, composed of a cell-laden compartment at its core and an extracellular vesicle (EV)-laden compartment at its shell for better integration of the CP with the host tissue.
Fri Nov 25 00:00:00 UTC 2022
Secreted Fas Decoys Enhance the Antitumor Activity of Engineered and Bystander T Cells in Fas Ligand-Expressing Solid Tumors.
Cancer immunology research
Bajgain P,Torres Chavez AG,Balasubramanian K,Fleckenstein L,Lulla P,Heslop HE,Vera J,Leen AM
300-02 was used in Cell Culture to indicate that secreted Fas decoys can augment the efficacy of both adoptively transferred and endogenous tumor-specific effector cells in FasL-expressing solid tumors.
Wed Nov 02 00:00:00 UTC 2022
Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells.
Cell communication and signaling : CCS
Long C,Guo R,Han R,Li K,Wan Y,Xu J,Gong X,Zhao Y,Yao X,Liu J
300-02 was used in Cell Culture to study how macrophages affect the behavior of induced pluripotent stem cells (iPSCs) by generating three macrophage subtypes and assess their effects on the proliferation, cardiac differentiation, and maturation of iPSCs.
Mon Jul 18 00:00:00 UTC 2022
Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation.
Frontiers in immunology
Atene CG,Fiorcari S,Mesini N,Alboni S,Martinelli S,Maccaferri M,Leonardi G,Potenza L,Luppi M,Maffei R,Marasca R
300-02 was used in In vitro experiments to study the functional role of the IDO1/Kyn/AHR axis in chronic lymphocytic leukemia (CLL).
Fri Apr 08 00:00:00 UTC 2022
A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers.
International journal of molecular sciences
Singh S,Murillo G,Richner J,Singh SP,Berleth E,Kumar V,Mehta R,Ramiya V,Parihar AS
300-02 was used in Cell Culture to report a first-in-class molecule, a novel, single domain camelid VHH antibody (15 kDa), SBT-100, that binds to both STAT3 and KRAS and can penetrate the tumor cell membrane, and significantly inhibit cancer cell growth.
Fri Jul 08 00:00:00 UTC 2022
Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.
Nature communications
Apriamashvili G,Vredevoogd DW,Krijgsman O,Bleijerveld OB,Ligtenberg MA,de Bruijn B,Boshuizen J,Traets JJH,D'Empaire Altimari D,van Vliet A,Lin CP,Visser NL,Londino JD,Sanchez-Hodge R,Oswalt LE,Altinok S,Schisler JC,Altelaar M,Peeper DS
300-02 was used in Sample Preparation (FC/FACS) to uncover STUB1 as a critical regulator of IFNγ-R1, and highlight the context-dependency of STUB1-regulated IFNγ signaling for immune checkpoint blockade outcome.
Fri Apr 08 00:00:00 UTC 2022
IL-6 drives T cell death to participate in lymphopenia in COVID-19.
International immunopharmacology
Zhou X,Ye G,Lv Y,Guo Y,Pan X,Li Y,Shen G,He Y,Lei P
300-02 was used in In vitro experiments to confirm that the T-cell lymphopenia, especially CD4+ T cell reduction in COVID-19 patients, was a reliable indicator of severity and hospitalization in infected patients.
Sat Oct 01 00:00:00 UTC 2022
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.
Nature communications
D'Addio F,Maestroni A,Assi E,Ben Nasr M,Amabile G,Usuelli V,Loretelli C,Bertuzzi F,Antonioli B,Cardarelli F,El Essawy B,Solini A,Gerling IC,Bianchi C,Becchi G,Mazzucchelli S,Corradi D,Fadini GP,Foschi D,Markmann JF,Orsi E,Škrha J,Camboni MG,Abdi R,James Shapiro AM,Folli F,Ludvigsson J,Del Prato S,Zuccotti G,Fiorina P
300-02 was used in Cell Culture to show that the death receptor TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction.
Thu Feb 03 00:00:00 UTC 2022
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Cancer discovery
Fonteneau G,Redding A,Hoag-Lee H,Sim ES,Heinrich S,Gaida MM,Grabocka E
300-02 was used in In vitro experiments to show that stress adaptation via the phase-separation organelles stress granules (SGs) mediates pancreatic ductal adenocarcinoma (PDAC) development.
Fri Aug 05 00:00:00 UTC 2022
Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters.
Science advances
Sun X,Bieber JM,Hammerlindl H,Chalkley RJ,Li KH,Burlingame AL,Jacobson MP,Wu LF,Altschuler SJ
300-02 was used in Cell Culture to study the cellular mechanisms that promote the emergence of cancer persisters and to pinpoint actionable vulnerabilities that eliminate them.
Fri Jan 28 00:00:00 UTC 2022
Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor.
mBio
Wang J,Luo J,Wen Z,Wang X,Shuai L,Zhong G,Wang C,Sun Z,Chen W,Ge J,Liu R,Wang X,Bu Z
Tue Feb 22 00:00:00 UTC 2022
Fam72a enforces error-prone DNA repair during antibody diversification.
Nature
Rogier M,Moritz J,Robert I,Lescale C,Heyer V,Abello A,Martin O,Capitani K,Thomas M,Thomas-Claudepierre AS,Laffleur B,Jouan F,Pinaud E,Tarte K,Cogné M,Conticello SG,Soutoglou E,Deriano L,Reina-San-Martin B
Wed Dec 01 00:00:00 UTC 2021
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
300-02 was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 UTC 2021
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
300-02 was used in Enzyme-linked immunosorbent assay to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 UTC 2021
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell
Mills RJ,Humphrey SJ,Fortuna PRJ,Lor M,Foster SR,Quaife-Ryan GA,Johnston RL,Dumenil T,Bishop C,Rudraraju R,Rawle DJ,Le T,Zhao W,Lee L,Mackenzie-Kludas C,Mehdiabadi NR,Halliday C,Gilham D,Fu L,Nicholls SJ,Johansson J,Sweeney M,Wong NCW,Kulikowski E,Sokolowski KA,Tse BWC,Devilée L,Voges HK,Reynolds LT,Krumeich S,Mathieson E,Abu-Bonsrah D,Karavendzas K,Griffen B,Titmarsh D,Elliott DA,McMahon J,Suhrbier A,Subbarao K,Porrello ER,Smyth MJ,Engwerda CR,MacDonald KPA,Bald T,James DE,Hudson JE
Thu Apr 15 00:00:00 UTC 2021
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Immunity
Ramaswamy A,Brodsky NN,Sumida TS,Comi M,Asashima H,Hoehn KB,Li N,Liu Y,Shah A,Ravindra NG,Bishai J,Khan A,Lau W,Sellers B,Bansal N,Guerrerio P,Unterman A,Habet V,Rice AJ,Catanzaro J,Chandnani H,Lopez M,Kaminski N,Dela Cruz CS,Tsang JS,Wang Z,Yan X,Kleinstein SH,van Dijk D,Pierce RW,Hafler DA,Lucas CL
Tue May 11 00:00:00 UTC 2021
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.
Immunity
Dersh D,Phelan JD,Gumina ME,Wang B,Arbuckle JH,Holly J,Kishton RJ,Markowitz TE,Seedhom MO,Fridlyand N,Wright GW,Huang DW,Ceribelli M,Thomas CJ,Lack JB,Restifo NP,Kristie TM,Staudt LM,Yewdell JW
Tue Jan 12 00:00:00 UTC 2021
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
Circulation
Geisberger S,Bartolomaeus H,Neubert P,Willebrand R,Zasada C,Bartolomaeus T,McParland V,Swinnen D,Geuzens A,Maifeld A,Krampert L,Vogl M,Mähler A,Wilck N,Markó L,Tilic E,Forslund SK,Binger KJ,Stegbauer J,Dechend R,Kleinewietfeld M,Jantsch J,Kempa S,Müller DN
300-02 was used in Cell Culture to investigate effects of sodium changes on human and murine phagocytes.
Tue Jul 13 00:00:00 UTC 2021
Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer.
Cancer cell
Bagati A,Kumar S,Jiang P,Pyrdol J,Zou AE,Godicelj A,Mathewson ND,Cartwright ANR,Cejas P,Brown M,Giobbie-Hurder A,Dillon D,Agudo J,Mittendorf EA,Liu XS,Wucherpfennig KW
Mon Jan 11 00:00:00 UTC 2021
Differential immune responses in pregnant patients recovered from COVID-19.
Signal transduction and targeted therapy
Chen G,Zhang Y,Zhang Y,Ai J,Yang B,Cui M,Liao Q,Chen H,Bai H,Shang D,Chen J,Sun C,Liu H,Liu F,Mao B,Sun G,Chen L,Lin JW,Li K
Thu Jul 29 00:00:00 UTC 2021
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
Cell stem cell
Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD
300-02 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
Thu Jan 07 00:00:00 UTC 2021
Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.
The Journal of clinical investigation
Furlong-Silva J,Cross SD,Marriott AE,Pionnier N,Archer J,Steven A,Merker SS,Mack M,Hong YK,Taylor MJ,Turner JD
Mon Mar 01 00:00:00 UTC 2021
The key role of NLRP3 and STING in APOL1-associated podocytopathy.
The Journal of clinical investigation
Wu J,Raman A,Coffey NJ,Sheng X,Wahba J,Seasock MJ,Ma Z,Beckerman P,Laczkó D,Palmer MB,Kopp JB,Kuo JJ,Pullen SS,Boustany-Kari CM,Linkermann A,Susztak K
Fri Oct 15 00:00:00 UTC 2021
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.
The Journal of experimental medicine
Lee-Chang C,Miska J,Hou D,Rashidi A,Zhang P,Burga RA,Jusué-Torres I,Xiao T,Arrieta VA,Zhang DY,Lopez-Rosas A,Han Y,Sonabend AM,Horbinski CM,Stupp R,Balyasnikova IV,Lesniak MS
Mon Jan 04 00:00:00 UTC 2021
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
Journal of internal medicine
Baumgartner R,Berg M,Matic L,Polyzos KP,Forteza MJ,Hjorth SA,Schwartz TW,Paulsson-Berne G,Hansson GK,Hedin U,Ketelhuth DFJ
Fri Jan 01 00:00:00 UTC 2021
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.
Cancer immunology research
Liu SQ,Grantham A,Landry C,Granda B,Chopra R,Chakravarthy S,Deutsch S,Vogel M,Russo K,Seiss K,Tschantz WR,Rejtar T,Ruddy DA,Hu T,Aardalen K,Wagner JP,Dranoff G,D'Alessio JA
300-02 was used in In vitro experiments to reveal multiple mechanisms that can be targeted to enhance the clinical potential of current and future T-cell-engaging CD3-bispecific antibody therapies.
Fri Jan 01 00:00:00 UTC 2021
lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration.
Molecular therapy. Nucleic acids
Zhao Y,Yu Z,Ma R,Zhang Y,Zhao L,Yan Y,Lv X,Zhang L,Su P,Bi J,Xu H,He M,Wei M
Fri Mar 05 00:00:00 UTC 2021
HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer.
Oncogene
Liu Y,Li X,Zhang H,Zhang M,Wei Y
Mon Mar 01 00:00:00 UTC 2021
Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis.
Blood advances
Le K,Sun J,Khawaja H,Shibata M,Maggirwar SB,Smith MR,Gupta M
Tue Jul 27 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
300-02 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 UTC 2021
Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature.
Journal of immunology (Baltimore, Md. : 1950)
Wu Z,Lau CM,Sottile R,Le Luduec JB,Panjwani MK,Conaty PM,Srpan K,Laib Sampaio K,Mertens T,Adler SP,Hill AB,Barker JN,Cheung NV,Sun JC,Hsu KC
Mon Nov 15 00:00:00 UTC 2021
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death.
Journal of immunology (Baltimore, Md. : 1950)
Bolívar BE,Brown-Suedel AN,Rohrman BA,Charendoff CI,Yazdani V,Belcher JD,Vercellotti GM,Flanagan JM,Bouchier-Hayes L
Thu Apr 15 00:00:00 UTC 2021
IFNs Reset the Differential Capacity of Human Monocyte Subsets to Produce IL-12 in Response to Microbial Stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Muglia Amancio A,Mittereder L,Carletti A,Tosh KW,Green D,Antonelli LR,Gazzinelli RT,Sher A,Jankovic D
Thu Apr 01 00:00:00 UTC 2021
Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.
Journal of cellular and molecular medicine
Liu Y,Du M,Lin HY
Sun Aug 01 00:00:00 UTC 2021
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition.
American journal of physiology. Gastrointestinal and liver physiology
Her JY,Lee Y,Kim SJ,Heo G,Choo J,Kim Y,Howe C,Rhee SH,Yu HS,Chung HY,Pothoulakis C,Im E
Fri Jan 01 00:00:00 UTC 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 UTC 2021
Anti-Inflammatory Effects of Lagerstroemia ovalifolia Teijsm. & Binn. in TNFα/IFNγ-Stimulated Keratinocytes.
Evidence-based complementary and alternative medicine : eCAM
Lee HS,Paik JH,Kwon OK,Paryanto I,Yuniato P,Ryu HW,Choi SH,Oh SR,Han SB,Park JW,Ahn KS
Sat Nov 20 00:00:00 UTC 2021
N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells.
Journal for immunotherapy of cancer
Sun Y,Jing J,Xu H,Xu L,Hu H,Tang C,Liu S,Wei Q,Duan R,Guo J,Yang L
300-02 was used in Sample Preparation to explore the significance of ADH-1 as a potential treatment strategy in prostate cancer.
Mon Mar 01 00:00:00 UTC 2021
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.
Cell discovery
Lv J,Wang Z,Qu Y,Zhu H,Zhu Q,Tong W,Bao L,Lv Q,Cong J,Li D,Deng W,Yu P,Song J,Tong WM,Liu J,Liu Y,Qin C,Huang B
Tue Apr 13 00:00:00 UTC 2021
PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.
Frontiers in immunology
Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y
300-02 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.
Mon Oct 25 00:00:00 UTC 2021
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Cell death & disease
Woznicki JA,Saini N,Flood P,Rajaram S,Lee CM,Stamou P,Skowyra A,Bustamante-Garrido M,Regazzoni K,Crawford N,McDade SS,Longley DB,Aza-Blanc P,Shanahan F,Zulquernain SA,McCarthy J,Melgar S,McRae BL,Nally K
300-02 was used in In vitro experiments to identify JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human IECs by IFN-γ/TNF-α.
Thu Sep 23 00:00:00 UTC 2021
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
Cell reports
Parent AV,Faleo G,Chavez J,Saxton M,Berrios DI,Kerper NR,Tang Q,Hebrok M
Tue Aug 17 00:00:00 UTC 2021
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Nature communications
Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M
Fri May 21 00:00:00 UTC 2021
Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.
Nature communications
Morris R,Zhang Y,Ellyard JI,Vinuesa CG,Murphy JM,Laktyushin A,Kershaw NJ,Babon JJ
Wed Oct 20 00:00:00 UTC 2021
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Cell reports
Ghosh S,Nataraj NB,Noronha A,Patkar S,Sekar A,Mukherjee S,Winograd-Katz S,Kramarski L,Verma A,Lindzen M,Garcia DD,Green J,Eisenberg G,Gil-Henn H,Basu A,Lender Y,Weiss S,Oren M,Lotem M,Geiger B,Ruppin E,Yarden Y
Tue May 25 00:00:00 UTC 2021
Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate.
Metabolites
Winterhoff M,Chen F,Sahini N,Ebensen T,Kuhn M,Kaever V,Bähre H,Pessler F
300-02 was used in In vitro experiments to establish a sensitive high performance liquid chromatography-tandem mass spectrometry assay for the quantification of itaconate, mesaconate, citraconate, the pro-drug 4-octyl-itaconate, and selected TCA intermediates.
Mon Apr 26 00:00:00 UTC 2021
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Cancer discovery
Picco G,Cattaneo CM,van Vliet EJ,Crisafulli G,Rospo G,Consonni S,Vieira SF,Rodríguez IS,Cancelliere C,Banerjee R,Schipper LJ,Oddo D,Dijkstra KK,Cinatl J,Michaelis M,Yang F,Di Nicolantonio F,Sartore-Bianchi A,Siena S,Arena S,Voest EE,Bardelli A,Garnett MJ
300-02 was used in Cell Culture to inform the development of WRN as a therapeutic target, we performed WRN knockout or knockdown in 60 heterogeneous dMMR colorectal cancer preclinical models, demonstrating that WRN dependency is an almost universal feature and a robust marker for patient selection.
Sun Aug 01 00:00:00 UTC 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
Tue May 18 00:00:00 UTC 2021
ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes.
iScience
Ma M,Li H,Wang P,Yang W,Mi R,Zhuang J,Jiang Y,Lu Y,Shen X,Wu Y,Shen H
300-02 was used in Cell Culture to find that activating transcription factor 6 and fibroblast growth factor 2 levels were higher in SKG mice and in cartilage of pateints with ankylosing spondylitis-1.
Fri Jul 23 00:00:00 UTC 2021
Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer.
International journal of breast cancer
Ghimirey N,Steele C,Czerniecki BJ,Koski GK,Showalter LE
Tue May 04 00:00:00 UTC 2021
Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s.
Cancer immunology research
Daugan MV,Revel M,Russick J,Dragon-Durey MA,Gaboriaud C,Robe-Rybkine T,Poillerat V,Grunenwald A,Lacroix G,Bougouin A,Meylan M,Verkarre V,Oudard SM,Mejean A,Vano YA,Perkins G,Validire P,Cathelineau X,Sanchez-Salas R,Damotte D,Fremeaux-Bacchi V,Cremer I,Sautès-Fridman C,Fridman WH,Roumenina LT
300-02 was used in Cell Culture to find that complement activation, as reflected by high plasma C4d or as C4d deposits at the tumor site, was associated with poor prognosis in two cohorts of patients with ccRCC.
Sun Aug 01 00:00:00 UTC 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 UTC 2021
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells.
Scientific reports
Giese AA,Babendreyer A,Krappen P,Gross A,Strnad P,Düsterhöft S,Ludwig A
Mon Dec 20 00:00:00 UTC 2021
Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy.
iScience
Sureshchandra S,Marshall NE,Mendoza N,Jankeel A,Zulu MZ,Messaoudi I
Fri Jun 25 00:00:00 UTC 2021
Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease.
Scientific reports
Roberts KJ,Cubitt MF,Carlton TM,Rodrigues-Duarte L,Maggiore L,Chai R,Clare S,Harcourt K,MacDonald TT,Ray KP,Vossenkämper A,West MR,Crowe JS
Thu Sep 30 00:00:00 UTC 2021
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Cell
Raghavan S,Winter PS,Navia AW,Williams HL,DenAdel A,Lowder KE,Galvez-Reyes J,Kalekar RL,Mulugeta N,Kapner KS,Raghavan MS,Borah AA,Liu N,Väyrynen SA,Costa AD,Ng RWS,Wang J,Hill EK,Ragon DY,Brais LK,Jaeger AM,Spurr LF,Li YY,Cherniack AD,Booker MA,Cohen EF,Tolstorukov MY,Wakiro I,Rotem A,Johnson BE,McFarland JM,Sicinska ET,Jacks TE,Sullivan RJ,Shapiro GI,Clancy TE,Perez K,Rubinson DA,Ng K,Cleary JM,Crawford L,Manalis SR,Nowak JA,Wolpin BM,Hahn WC,Aguirre AJ,Shalek AK
300-02 was used in In vitro experiments to study distinct site and state-specific tumour microevironments in pancreatic cancer.
Thu Dec 09 00:00:00 UTC 2021
Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes.
Frontiers in immunology
Ardighieri L,Missale F,Bugatti M,Gatta LB,Pezzali I,Monti M,Gottardi S,Zanotti L,Bignotti E,Ravaggi A,Tognon G,Odicino F,Calza S,Missolo-Koussou Y,Ries CH,Helft J,Vermi W
300-02 was used in Cell Culture to investigate the use of high CD3+ T-cells and CD163+ tumor-associated macrophages on ovarian carcinomas therapy.
Wed Oct 27 00:00:00 UTC 2021
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Frontiers in immunology
Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP
300-02 was used in Cell Culture to investigate whether Cytochrome P450 26A1 (CYP26A1) regulates the polarization of uterine macrophages in early pregnancy.
Thu Feb 10 00:00:00 UTC 2022
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
300-02 was used in In vitro experiments to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 UTC 2021
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Cell reports
Trauelsen M,Hiron TK,Lin D,Petersen JE,Breton B,Husted AS,Hjorth SA,Inoue A,Frimurer TM,Bouvier M,O'Callaghan CA,Schwartz TW
Tue Jun 15 00:00:00 UTC 2021
IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy.
International journal of molecular sciences
Tsai ML,Tsai YG,Lin YC,Hsu YL,Chen YT,Tsai MK,Liao WT,Lin YC,Hung CH
300-02 was used in Cell Culture to induce mitophagy to stimulate M2 macrophage polarization in monocytes.
Tue Dec 21 00:00:00 UTC 2021
The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides.
Molecular & cellular proteomics : MCP
Komov L,Melamed Kadosh D,Barnea E,Admon A
Mon Mar 21 00:00:00 UTC 2022
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.
Communications biology
Lee HK,Jung O,Hennighausen L
Wed Jun 02 00:00:00 UTC 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
Tue Apr 20 00:00:00 UTC 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
Tue Apr 20 00:00:00 UTC 2021
Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics.
Advanced biology
Jain P,Nishiguchi A,Linz G,Wessling M,Ludwig A,Rossaint R,Möller M,Singh S
Sun Aug 01 00:00:00 UTC 2021
Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.
Cell reports
Crump NT,Hadjinicolaou AV,Xia M,Walsby-Tickle J,Gileadi U,Chen JL,Setshedi M,Olsen LR,Lau IJ,Godfrey L,Quek L,Yu Z,Ballabio E,Barnkob MB,Napolitani G,Salio M,Koohy H,Kessler BM,Taylor S,Vyas P,McCullagh JSO,Milne TA,Cerundolo V
Tue May 11 00:00:00 UTC 2021
Necroptosis Underlies Neutrophilic Inflammation Associated with the Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
Journal of inflammation research
Xie Y,Li M,Chen K,Zhu H,Tang M,Zhou C,Zheng Y,Wen J,Han M,Zhang J,Zhao K,Xiao H,Li H
300-02 was used in Enzyme-linked immunosorbent assay to investigate necroptosis in chronic rhinosinusitis with nasal polyps.
Tue Apr 26 00:00:00 UTC 2022
IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells.
Cancers
Carbotti G,Dozin B,Martini S,Giordano C,Scordamaglia F,Croce M,Filaci G,Ferrini S,Fabbi M
300-02 was used in Cell Culture to suggest a potential role of IL-27 in PD-L1-driven immune resistance in Malignant mesothelioma (MM).
Mon Aug 09 00:00:00 UTC 2021
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation.
Cancers
Shen Y,Liu L,Wang M,Xu B,Lyu R,Shi YG,Tan L
300-02 was used in In vitro experiments to identify a new epigenetic regulatory mechanism of PD-L1 gene transcription, linking the catalytic activity-independent role of TET2 to the anti-tumor immunity in breast cancer.
Tue May 04 00:00:00 UTC 2021
The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.
Nature communications
Yuan T,Annamalai K,Naik S,Lupse B,Geravandi S,Pal A,Dobrowolski A,Ghawali J,Ruhlandt M,Gorrepati KDD,Azizi Z,Lim DS,Maedler K,Ardestani A
Fri Aug 13 00:00:00 UTC 2021
The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.
Nature communications
Yuan T,Annamalai K,Naik S,Lupse B,Geravandi S,Pal A,Dobrowolski A,Ghawali J,Ruhlandt M,Gorrepati KDD,Azizi Z,Lim DS,Maedler K,Ardestani A
Fri Aug 13 00:00:00 UTC 2021
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.
Nature communications
Bolis M,Bossi D,Vallerga A,Ceserani V,Cavalli M,Impellizzieri D,Di Rito L,Zoni E,Mosole S,Elia AR,Rinaldi A,Pereira Mestre R,D'Antonio E,Ferrari M,Stoffel F,Jermini F,Gillessen S,Bubendorf L,Schraml P,Calcinotto A,Corey E,Moch H,Spahn M,Thalmann G,Kruithof-de Julio M,Rubin MA,Theurillat JP
300-02 was used in In vitro experiments to provide a user-friendly web-resource enabling the investigation of dynamic transcriptional perturbations linked to disease progression.
Thu Dec 02 00:00:00 UTC 2021
Titanium Nanoparticles Enhance Production and Suppress Stabilin-1-Mediated Clearance of GDF-15 in Human Primary Macrophages.
Frontiers in immunology
Silva-Bermudez LS,Sevastyanova TN,Schmuttermaier C,De La Torre C,Schumacher L,Klüter H,Kzhyshkowska J
300-02 was used in In vitro experiments to study how titanium nanoparticles (TiNPs) affect the healing activities of macrophages and their release of circulating cytokines to identify the transcriptional program induced and suppressed by TiNPs in human pro-inflammatory and healing macrophages.
Wed Feb 16 00:00:00 UTC 2022
CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.
Hepatology communications
Yugawa K,Itoh S,Yoshizumi T,Iseda N,Tomiyama T,Morinaga A,Toshima T,Harada N,Kohashi K,Oda Y,Mori M
Mon Feb 01 00:00:00 UTC 2021
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Cell reports
Lupse B,Annamalai K,Ibrahim H,Kaur S,Geravandi S,Sarma B,Pal A,Awal S,Joshi A,Rafizadeh S,Madduri MK,Khazaei M,Liu H,Yuan T,He W,Gorrepati KDD,Azizi Z,Qi Q,Ye K,Oberholzer J,Maedler K,Ardestani A
Tue Aug 03 00:00:00 UTC 2021
Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function.
Scientific reports
Stephens M,Liao S,von der Weid PY
Thu Jan 14 00:00:00 UTC 2021
Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.
Nature communications
Fisher AL,Sangkhae V,Balušíková K,Palaskas NJ,Ganz T,Nemeth E
Tue Jun 29 00:00:00 UTC 2021
Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
Communications biology
Hou XX,Wang XQ,Zhou WJ,Li DJ
Fri Apr 23 00:00:00 UTC 2021
Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro.
International journal of molecular sciences
Tamò L,Fytianos K,Caldana F,Simillion C,Feki A,Nita I,Heller M,Geiser T,Gazdhar A
300-02 was used in Cell Culture to investigate macrophage recruitment in tissue repair by induced pluripotent stem cell secretome.
Tue Jan 19 00:00:00 UTC 2021
JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.
iScience
Jankowski J,Lee HK,Wilflingseder J,Hennighausen L
Fri Aug 20 00:00:00 UTC 2021
TNF-α and IL-1β sensitize human MSC for IFN-γ signaling and enhance neutrophil recruitment.
European journal of immunology
Hackel A,Aksamit A,Bruderek K,Lang S,Brandau S
Mon Feb 01 00:00:00 UTC 2021
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain.
Journal of leukocyte biology
Kiianitsa K,Kurtz I,Beeman N,Matsushita M,Chien WM,Raskind WH,Korvatska O
300-02 was used in In vitro experiments to suggest that changes in the balance of two mutually exclusive TREM2 isoforms may modify the dosage of full-length transcript potentially weakening some TREM2 receptor functions in the human brain.
Mon Nov 01 00:00:00 UTC 2021
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Science immunology
Niyonzima N,Rahman J,Kunz N,West EE,Freiwald T,Desai JV,Merle NS,Gidon A,Sporsheim B,Lionakis MS,Evensen K,Lindberg B,Skagen K,Skjelland M,Singh P,Haug M,Ruseva MM,Kolev M,Bibby J,Marshall O,O'Brien B,Deeks N,Afzali B,Clark RJ,Woodruff TM,Pryor M,Yang ZH,Remaley AT,Mollnes TE,Hewitt SM,Yan B,Kazemian M,Kiss MG,Binder CJ,Halvorsen B,Espevik T,Kemper C
300-02 was used in Sample Preparation (Western Blotting) to suggest that the complosome is a contributor to the biologic processes underlying sterile inflammation and indicate that targeting this system could be beneficial in macrophage-dependent diseases, such as atherosclerosis.
Fri Dec 24 00:00:00 UTC 2021
Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis.
Scientific reports
Kanai R,Nakashima A,Doi S,Kimura T,Yoshida K,Maeda S,Ishiuchi N,Yamada Y,Ike T,Doi T,Kato Y,Masaki T
Wed Jan 13 00:00:00 UTC 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation.
Nature communications
Arenas EJ,Martínez-Sabadell A,Rius Ruiz I,Román Alonso M,Escorihuela M,Luque A,Fajardo CA,Gros A,Klein C,Arribas J
Tue Feb 23 00:00:00 UTC 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 UTC 2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons
Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD
300-02 was used in Cell Culture to investigate correlations between cytokine expression and mortality.
Wed Jul 21 00:00:00 UTC 2021
CASB: a concanavalin A-based sample barcoding strategy for single-cell sequencing.
Molecular systems biology
Fang L,Li G,Sun Z,Zhu Q,Cui H,Li Y,Zhang J,Liang W,Wei W,Hu Y,Chen W
Thu Apr 01 00:00:00 UTC 2021
ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes.
Cell death & disease
Pezzè L,Meškytė EM,Forcato M,Pontalti S,Badowska KA,Rizzotto D,Skvortsova II,Bicciato S,Ciribilli Y
Tue Jul 27 00:00:00 UTC 2021
Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy.
Cell reports
Roverato ND,Sailer C,Catone N,Aichem A,Stengel F,Groettrup M
Tue Mar 16 00:00:00 UTC 2021
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
Thu Apr 16 00:00:00 UTC 2020
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.
Cell
Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S
Thu Mar 19 00:00:00 UTC 2020
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
Nature genetics
Kinker GS,Greenwald AC,Tal R,Orlova Z,Cuoco MS,McFarland JM,Warren A,Rodman C,Roth JA,Bender SA,Kumar B,Rocco JW,Fernandes PACM,Mader CC,Keren-Shaul H,Plotnikov A,Barr H,Tsherniak A,Rozenblatt-Rosen O,Krizhanovsky V,Puram SV,Regev A,Tirosh I
Sun Nov 01 00:00:00 UTC 2020
Impact of checkpoint blockade on cancer vaccine-activated CD8+ T cell responses.
The Journal of experimental medicine
Santos PM,Adamik J,Howes TR,Du S,Vujanovic L,Warren S,Gambotto A,Kirkwood JM,Butterfield LH
Mon Jul 06 00:00:00 UTC 2020
Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies.
EMBO molecular medicine
Huyghe L,Van Parys A,Cauwels A,Van Lint S,De Munter S,Bultinck J,Zabeau L,Hostens J,Goethals A,Vanderroost N,Verhee A,Uzé G,Kley N,Peelman F,Vandekerckhove B,Brouckaert P,Tavernier J
Fri Feb 07 00:00:00 UTC 2020
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.
Proceedings of the National Academy of Sciences of the United States of America
Preciado-Llanes L,Aulicino A,Canals R,Moynihan PJ,Zhu X,Jambo N,Nyirenda TS,Kadwala I,Sousa Gerós A,Owen SV,Jambo KC,Kumwenda B,Veerapen N,Besra GS,Gordon MA,Hinton JCD,Napolitani G,Salio M,Simmons A
Tue Aug 25 00:00:00 UTC 2020
AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy.
Journal of cachexia, sarcopenia and muscle
Abou-Samra M,Selvais CM,Boursereau R,Lecompte S,Noel L,Brichard SM
Wed Apr 01 00:00:00 UTC 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 UTC 2020
Major histocompatibility complexes are up-regulated in glomerular endothelial cells via activation of c-Jun N-terminal kinase in 5/6 nephrectomy mice.
British journal of pharmacology
Zhu D,Tang Q,Yu B,Meng M,Liu W,Li J,Zhu T,Vanhoutte PM,Leung SWS,Zhang Y,Shi Y
Sun Nov 01 00:00:00 UTC 2020
Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis.
Clinical and translational medicine
Strack E,Rolfe PA,Fink AF,Bankov K,Schmid T,Solbach C,Savai R,Sha W,Pradel L,Hartmann S,Brüne B,Weigert A
Tue Dec 01 00:00:00 UTC 2020
Pleiotropic effects of vitamin D3 on CD4+ T lymphocytes mediated by human periodontal ligament cells and inflammatory environment.
Journal of clinical periodontology
Behm C,Blufstein A,Gahn J,Kubin B,Moritz A,Rausch-Fan X,Andrukhov O
Mon Jun 01 00:00:00 UTC 2020
Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes.
Molecular oncology
Pribyl M,Hubackova S,Moudra A,Vancurova M,Polackova H,Stopka T,Jonasova A,Bokorova R,Fuchs O,Stritesky J,Salovska B,Bartek J,Hodny Z
Thu Oct 01 00:00:00 UTC 2020
Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data.
Immunology
Toufiq M,Roelands J,Alfaki M,Syed Ahamed Kabeer B,Saadaoui M,Lakshmanan AP,Bangarusamy DK,Murugesan S,Bedognetti D,Hendrickx W,Al Khodor S,Terranegra A,Rinchai D,Chaussabel D,Garand M
Tue Dec 01 00:00:00 UTC 2020
Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane-bound and secreted β2m-HLA-G fusion proteins.
Stem cells (Dayton, Ohio)
Shi L,Li W,Liu Y,Chen Z,Hui Y,Hao P,Xu X,Zhang S,Feng H,Zhang B,Zhou S,Li N,Xiao L,Liu L,Ma L,Zhang X
Sun Nov 01 00:00:00 UTC 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 UTC 2020
A human co-culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Leite DM,Zvar Baskovic B,Civita P,Neto C,Gumbleton M,Pilkington GJ
Wed Jan 01 00:00:00 UTC 2020
Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity.
Frontiers in oncology
Sam J,Colombetti S,Fauti T,Roller A,Biehl M,Fahrni L,Nicolini V,Perro M,Nayak T,Bommer E,Schoenle A,Karagianni M,Le Clech M,Steinhoff N,Klein C,Umaña P,Bacac M
300-02 was used in Sample Preparation (FC/FACS) to show that the elucidation of additional resistance mechanisms beyond the PD-1/PD-L1 axis will constitute an important milestone for our understanding of factors determining tumor escape and deepening of TCB anti-tumor responses in both solid tumors and hematological disorders.
Fri Sep 24 00:00:00 UTC 2021
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Fu M,Li M,Hu H,Gong S,Hu Q
Tue Sep 01 00:00:00 UTC 2020
The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Rijvers L,Melief MJ,van Langelaar J,van der Vuurst de Vries RM,Wierenga-Wolf AF,Koetzier SC,Priatel JJ,Jorritsma T,van Ham SM,Hintzen RQ,van Luijn MM
Sat Aug 15 00:00:00 UTC 2020
Effect of Ibrutinib on the IFN Response of Chronic Lymphocytic Leukemia Cells.
Journal of immunology (Baltimore, Md. : 1950)
Xia M,Luo TY,Shi Y,Wang G,Tsui H,Harari D,Spaner DE
Sun Nov 15 00:00:00 UTC 2020
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.
Journal of immunology (Baltimore, Md. : 1950)
Taylor S,Whitfield M,Barratt J,Didangelos A
Thu Oct 15 00:00:00 UTC 2020
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.
Journal of immunology (Baltimore, Md. : 1950)
Brouwers H,Jónasdóttir HS,Kuipers ME,Kwekkeboom JC,Auger JL,Gonzalez-Torres M,López-Vicario C,Clària J,Freysdottir J,Hardardottir I,Garrido-Mesa J,Norling LV,Perretti M,Huizinga TWJ,Kloppenburg M,Toes REM,Binstadt B,Giera M,Ioan-Facsinay A
Sun Nov 15 00:00:00 UTC 2020
Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
Molecular carcinogenesis
Toews K,Grunewald L,Schwiebert S,Klaus A,Winkler A,Ali S,Zirngibl F,Astrahantseff K,Wagner DL,Henssen AG,Deubzer HE,Schulte JH,Ochsenreither S,Eggert A,Künkele A
Wed Jul 01 00:00:00 UTC 2020
Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy.
Cancer biology & therapy
Lin X,Zeng T,Lin J,Zhang Q,Cheng H,Fang S,Lin S,Chen Y,Xu Y,Lin J
300-02 was used in In vivo experiments to investigate PD-L1 and TIL presence in the tumour microenvironment of inflammatory cancers.
Mon Mar 29 00:00:00 UTC 2021
Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy.
Cancer biology & therapy
Lin X,Zeng T,Lin J,Zhang Q,Cheng H,Fang S,Lin S,Chen Y,Xu Y,Lin J
300-02 was used in In vivo experiments to investigate PD-L1 and TIL presence in the tumour microenvironment of inflammatory cancers.
Mon Mar 29 00:00:00 UTC 2021
Isolation and characterization of microvesicles from mesenchymal stem cells.
Methods (San Diego, Calif.)
Mohammadi MR,Riazifar M,Pone EJ,Yeri A,Van Keuren-Jensen K,Lässer C,Lotvall J,Zhao W
300-02 was used in Cell Culture to examine the potential of MVs to exert immunomodulatory effects through induction of regulatory T cells.
Fri May 01 00:00:00 UTC 2020
Suppression of complement component 2 expression by hepatitis B virus contributes to the viral persistence in chronic hepatitis B patients.
Journal of viral hepatitis
Ning G,Zhen LM,Xu WX,Li XJ,Wu LN,Liu Y,Xie C,Peng L
Thu Oct 01 00:00:00 UTC 2020
BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin.
Cell adhesion & migration
Verma S,Kang AK,Pal R,Gupta SK
300-02 was used in In vitro experiments to show that IFN-γ decreases the invasion of HTR-8/SVneo cells by STAT1 and AKT activation via increased expression of BST2 and E-cadherin.
Tue Dec 01 00:00:00 UTC 2020
Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus.
European journal of oral sciences
Schreurs O,Karatsaidis A,Balta MG,Grung B,Hals EKB,Schenck K
Sat Feb 01 00:00:00 UTC 2020
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Nature communications
Santos JC,Boucher D,Schneider LK,Demarco B,Dilucca M,Shkarina K,Heilig R,Chen KW,Lim RYH,Broz P
Wed Jun 24 00:00:00 UTC 2020
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Nature communications
Santos JC,Boucher D,Schneider LK,Demarco B,Dilucca M,Shkarina K,Heilig R,Chen KW,Lim RYH,Broz P
Wed Jun 24 00:00:00 UTC 2020
Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage.
The Journal of biological chemistry
Jobin PG,Solis N,Machado Y,Bell PA,Rai SK,Kwon NH,Kim S,Overall CM,Butler GS
Fri Feb 21 00:00:00 UTC 2020
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s.
Nature communications
Tunbak H,Enriquez-Gasca R,Tie CHC,Gould PA,Mlcochova P,Gupta RK,Fernandes L,Holt J,van der Veen AG,Giampazolias E,Burns KH,Maillard PV,Rowe HM
Tue Nov 03 00:00:00 UTC 2020
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells.
Cell reports
Leite NC,Sintov E,Meissner TB,Brehm MA,Greiner DL,Harlan DM,Melton DA
300-02 was used in Cell activation to demonstrate a cell-type-specific response by autologous immune cells against induced pluripotent stem cell-derived β cells, along with a reduced effect on α cells.
Tue Jul 14 00:00:00 UTC 2020
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Cell death & disease
Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC
Mon Mar 02 00:00:00 UTC 2020
Down-regulation of UL16-binding protein 3 mediated by interferon-gamma impairs immune killing in nasopharyngeal carcinoma.
American journal of translational research
Guo L,Chen Y,Wang J,Chen C
300-02 was used in In vitro experiments to investigate the effect of IFN-γ on the expression of natural killer group 2, member D ligands (NKG2DLs), a series of immune-activating proteins, and their further effect on immune killing in NPC.
Tue Nov 17 00:00:00 UTC 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 UTC 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 UTC 2020
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
Frontiers in immunology
Korvatska O,Kiianitsa K,Ratushny A,Matsushita M,Beeman N,Chien WM,Satoh JI,Dorschner MO,Keene CD,Bammler TK,Bird TD,Raskind WH
300-02 was used in Cell Culture to point to a role of the TREM2 receptor in the control of the interferon type I response in myeloid cells and provide insight regarding the contribution of R47H TREM2 to AD pathology.
Fri Apr 30 00:00:00 UTC 2021
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
Wed Feb 26 00:00:00 UTC 2020
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
Wed Feb 26 00:00:00 UTC 2020
mTOR sustains inflammatory response in celiac disease.
Scientific reports
Sedda S,Dinallo V,Marafini I,Franzè E,Paoluzi OA,Izzo R,Giuffrida P,Di Sabatino A,Corazza GR,Monteleone G
Wed Jul 01 00:00:00 UTC 2020
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
International journal of biological sciences
Xiang Z,Liu J,Shi D,Chen W,Li J,Yan R,Bi Y,Hu W,Zhu Z,Yu Y,Yang Z
Mon Aug 24 00:00:00 UTC 2020
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Nature communications
Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B
Tue Apr 14 00:00:00 UTC 2020
Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer.
Endocrine connections
Aghajani MJ,Yang T,Schmitz U,James A,McCafferty CE,de Souza P,Niles N,Roberts TL
300-02 was used in Cell Culture to investigate the relationship between PD-L1 and EMT in thyroid cancer.
Thu Oct 01 00:00:00 UTC 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 UTC 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 UTC 2020
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma.
Nature communications
Tao W,Chu C,Zhou W,Huang Z,Zhai K,Fang X,Huang Q,Zhang A,Wang X,Yu X,Huang H,Wu Q,Sloan AE,Yu JS,Li X,Stark GR,Rich JN,Bao S
Mon Jun 15 00:00:00 UTC 2020
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Cell death & disease
Woznicki JA,Flood P,Bustamante-Garrido M,Stamou P,Moloney G,Fanning A,Zulquernain SA,McCarthy J,Shanahan F,Melgar S,Nally K
Mon Jan 27 00:00:00 UTC 2020
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Cell death & disease
Woznicki JA,Flood P,Bustamante-Garrido M,Stamou P,Moloney G,Fanning A,Zulquernain SA,McCarthy J,Shanahan F,Melgar S,Nally K
Mon Jan 27 00:00:00 UTC 2020
Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection.
Nature communications
Sandu I,Cerletti D,Claassen M,Oxenius A
Tue Sep 08 00:00:00 UTC 2020
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
bioRxiv : the preprint server for biology
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
300-02 was used in In vitro experiments to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.
Fri Nov 13 00:00:00 UTC 2020
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.
Cell death & disease
Faergeman SL,Evans H,Attfield KE,Desel C,Kuttikkatte SB,Sommerlund M,Jensen LT,Frokiaer J,Friese MA,Matthews PM,Luchtenborg C,Brügger B,Oturai AB,Dendrou CA,Fugger L
Fri May 01 00:00:00 UTC 2020
Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors.
Molecular & cellular proteomics : MCP
Vainer ED,Kania-Almog J,Zatara G,Levin Y,Vainer GW
Thu Oct 01 00:00:00 UTC 2020
Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus.
Molecular cell
Mineo M,Lyons SM,Zdioruk M,von Spreckelsen N,Ferrer-Luna R,Ito H,Alayo QA,Kharel P,Giantini Larsen A,Fan WY,Auduong S,Grauwet K,Passaro C,Khalsa JK,Shah K,Reardon DA,Ligon KL,Beroukhim R,Nakashima H,Ivanov P,Anderson PJ,Lawler SE,Chiocca EA
300-02 was used in In vitro experiments to identify the IFN-stimulated non-coding RNA 1 (INCR1) as a long noncoding RNA (lncRNA) transcribed from the PD-L1 locus and show that INCR1 controls IFNγ signaling in multiple tumor types.
Thu Jun 18 00:00:00 UTC 2020
EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation.
Cell death & disease
Zhang T,Yang L,Ke Y,Lei J,Shen S,Shao S,Zhang C,Zhu Z,Dang E,Wang G
Sat Oct 03 00:00:00 UTC 2020
The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation.
The Journal of biological chemistry
Boehm AN,Bialas J,Catone N,Sacristan-Reviriego A,van der Spuy J,Groettrup M,Aichem A
Fri Oct 16 00:00:00 UTC 2020
Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer.
Scientific reports
Capellero S,Erriquez J,Melano C,Mesiano G,Genta S,Pisacane A,Mittica G,Ghisoni E,Olivero M,Di Renzo MF,Aglietta M,Sangiolo D,Valabrega G
Wed Apr 15 00:00:00 UTC 2020
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.
Cell systems
Morinishi L,Kochanowski K,Levine RL,Wu LF,Altschuler SJ
300-02 was used in Cell Culture to study the functional and phenotypic effects of a TET2 mutation in AML and illustrate how a single gene mutation can alter a cells' phenotypic plasticity.
Wed Jul 22 00:00:00 UTC 2020
Predicting toxins found in toxin-antitoxin systems with a role in host-induced Burkholderia pseudomallei persistence.
Scientific reports
Ross BN,Thiriot JD,Wilson SM,Torres AG
Fri Oct 09 00:00:00 UTC 2020
Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.
Cells
Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N
300-02 was used in In vitro experiments to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.
Wed Feb 19 00:00:00 UTC 2020
Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures.
Scientific reports
Lowin T,Anssar TM,Bäuml M,Classen T,Schneider M,Pongratz G
Tue Jan 21 00:00:00 UTC 2020
CD163+ tumor-associated macrophage accumulation in breast cancer patients reflects both local differentiation signals and systemic skewing of monocytes.
Clinical & translational immunology
Ramos RN,Rodriguez C,Hubert M,Ardin M,Treilleux I,Ries CH,Lavergne E,Chabaud S,Colombe A,Trédan O,Guedes HG,Laginha F,Richer W,Piaggio E,Barbuto JAM,Caux C,Ménétrier-Caux C,Bendriss-Vermare N
Tue Apr 12 00:00:00 UTC 2022
CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer.
Scientific reports
Friese C,Harbst K,Borch TH,Westergaard MCW,Pedersen M,Kverneland A,Jönsson G,Donia M,Svane IM,Met Ö
Tue Mar 03 00:00:00 UTC 2020
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Nature communications
Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H
Thu Dec 10 00:00:00 UTC 2020
Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.
Cancers
Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L
300-02 was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.
Tue Oct 20 00:00:00 UTC 2020
Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis.
Scientific reports
Dijkman K,Lubbers R,Borggreven NV,Ottenhoff THM,Joosten SA,Trouw LA,Verreck FAW
Tue Apr 14 00:00:00 UTC 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 UTC 2020
RPTPε promotes M2-polarized macrophage migration through ROCK2 signaling and podosome formation.
Journal of cell science
Lapointe F,Turcotte S,Roy J,Bissonnette E,Rola-Pleszczynski M,Stankova J
300-02 was used in Cell Culture to show that differentiation and polarization of monocytes into M2-polarized hMDMs modulates the expression of PTPε isoforms and RPTPε is involved in podosome distribution, ROCK2 activation and migration in response to LTD4.
Tue Jan 21 00:00:00 UTC 2020
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells.
Cancers
Carbotti G,Petretto A,Naschberger E,Stürzl M,Martini S,Mingari MC,Filaci G,Ferrini S,Fabbi M
300-02 was used in Cell Culture to study novel extracellular mediators which are potentially involved in pithelial ovarian cancer (EOC) biology by analyzing the effect of IL-27 or IFN-γ on the secretome of cultured EOC cells by mass-spectrometry (nano-UHPLC-MS/MS).
Wed Feb 19 00:00:00 UTC 2020
TLR8 Is a Sensor of RNase T2 Degradation Products.
Cell
Greulich W,Wagner M,Gaidt MM,Stafford C,Cheng Y,Linder A,Carell T,Hornung V
Wed Nov 27 00:00:00 UTC 2019
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.
Cell
Poggio M,Hu T,Pai CC,Chu B,Belair CD,Chang A,Montabana E,Lang UE,Fu Q,Fong L,Blelloch R
Thu Apr 04 00:00:00 UTC 2019
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
Cell
Liu CX,Li X,Nan F,Jiang S,Gao X,Guo SK,Xue W,Cui Y,Dong K,Ding H,Qu B,Zhou Z,Shen N,Yang L,Chen LL
Thu May 02 00:00:00 UTC 2019
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Cell
Georgouli M,Herraiz C,Crosas-Molist E,Fanshawe B,Maiques O,Perdrix A,Pandya P,Rodriguez-Hernandez I,Ilieva KM,Cantelli G,Karagiannis P,Mele S,Lam H,Josephs DH,Matias-Guiu X,Marti RM,Nestle FO,Orgaz JL,Malanchi I,Fruhwirth GO,Karagiannis SN,Sanz-Moreno V
Thu Feb 07 00:00:00 UTC 2019
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.
Immunity
Pai CS,Huang JT,Lu X,Simons DM,Park C,Chang A,Tamaki W,Liu E,Roybal KT,Seagal J,Chen M,Hagihara K,Wei XX,DuPage M,Kwek SS,Oh DY,Daud A,Tsai KK,Wu C,Zhang L,Fasso M,Sachidanandam R,Jayaprakash A,Lin I,Casbon AJ,Kinsbury GA,Fong L
Tue Feb 19 00:00:00 UTC 2019
Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.
Immunity
Takeda A,Hollmén M,Dermadi D,Pan J,Brulois KF,Kaukonen R,Lönnberg T,Boström P,Koskivuo I,Irjala H,Miyasaka M,Salmi M,Butcher EC,Jalkanen S
Tue Sep 17 00:00:00 UTC 2019
Low-dose chidamide restores immune tolerance in ITP in mice and humans.
Blood
Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M
Thu Feb 14 00:00:00 UTC 2019
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
Blood
Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A
Thu May 09 00:00:00 UTC 2019
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes.
The Journal of clinical investigation
Gros A,Tran E,Parkhurst MR,Ilyas S,Pasetto A,Groh EM,Robbins PF,Yossef R,Garcia-Garijo A,Fajardo CA,Prickett TD,Jia L,Gartner JJ,Ray S,Ngo L,Wunderllich JR,Yang JC,Rosenberg SA
Fri Nov 01 00:00:00 UTC 2019
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
The Journal of clinical investigation
Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC
Mon Jul 15 00:00:00 UTC 2019
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors.
The Journal of clinical investigation
Chen F,Zou Z,Du J,Su S,Shao J,Meng F,Yang J,Xu Q,Ding N,Yang Y,Liu Q,Wang Q,Sun Z,Zhou S,Du S,Wei J,Liu B
Wed May 01 00:00:00 UTC 2019
Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade.
Science translational medicine
Shekarian T,Sivado E,Jallas AC,Depil S,Kielbassa J,Janoueix-Lerosey I,Hutter G,Goutagny N,Bergeron C,Viari A,Valsesia-Wittmann S,Caux C,Marabelle A
300-02 was used in Sample Preparation (FC/FACS) to study whether anti-infectious disease vaccines could be used as a commercially available source of immunostimulatory agents for cancer immunotherapy.
Wed Oct 23 00:00:00 UTC 2019
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Proceedings of the National Academy of Sciences of the United States of America
Lu Y,Stuart JH,Talbot-Cooper C,Agrawal-Singh S,Huntly B,Smid AI,Snowden JS,Dupont L,Smith GL
Tue Jun 11 00:00:00 UTC 2019
Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release.
Proceedings of the National Academy of Sciences of the United States of America
Göbel K,Asaridou CM,Merker M,Eichler S,Herrmann AM,Geuß E,Ruck T,Schüngel L,Groeneweg L,Narayanan V,Schneider-Hohendorf T,Gross CC,Wiendl H,Kehrel BE,Kleinschnitz C,Meuth SG
Wed Jan 02 00:00:00 UTC 2019
TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium.
Mucosal immunology
Birkl D,Quiros M,García-Hernández V,Zhou DW,Brazil JC,Hilgarth R,Keeney J,Yulis M,Bruewer M,García AJ,O Leary MN,Parkos CA,Nusrat A
300-02 was used in In vitro experiments to show that TNFα promotes intestinal mucosal repair through upregulation of the GPCR platelet activating factor receptor (PAFR) in the intestinal epithelium.
Mon Jul 01 00:00:00 UTC 2019
The IFN-γ-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition.
Mucosal immunology
Lee M,Kim DW,Khalmuratova R,Shin SH,Kim YM,Han DH,Kim HJ,Kim DY,Rhee CS,Park JW,Shin HW
Wed May 01 00:00:00 UTC 2019
Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production.
Glia
Kamermans A,Planting KE,Jalink K,van Horssen J,de Vries HE
Tue Jan 01 00:00:00 UTC 2019
Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.
Stem cells translational medicine
Chahal J,Gómez-Aristizábal A,Shestopaloff K,Bhatt S,Chaboureau A,Fazio A,Chisholm J,Weston A,Chiovitti J,Keating A,Kapoor M,Ogilvie-Harris DJ,Syed KA,Gandhi R,Mahomed NN,Marshall KW,Sussman MS,Naraghi AM,Viswanathan S
Thu Aug 01 00:00:00 UTC 2019
Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies.
Molecular oncology
Hubackova S,Pribyl M,Kyjacova L,Moudra A,Dzijak R,Salovska B,Strnad H,Tambor V,Imrichova T,Svec J,Vodicka P,Vaclavikova R,Rob L,Bartek J,Hodny Z
Mon Jul 01 00:00:00 UTC 2019
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells.
Acta pharmacologica Sinica
Shan H,Yao S,Ye Y,Yu Q
300-02 was used in Sample Preparation to investigate STAT3 targeting by B6 in cancer.
Sun Dec 01 00:00:00 UTC 2019
Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.
European journal of immunology
Maeda A,Digifico E,Andon FT,Mantovani A,Allavena P
Wed May 01 00:00:00 UTC 2019
Supplementary granulocyte macrophage colony-stimulating factor to chemotherapy and programmed death-ligand 1 blockade decreases local recurrence after surgery in bladder cancer.
Cancer science
Miyake M,Hori S,Ohnishi S,Toritsuka M,Fujii T,Shimizu T,Owari T,Morizawa Y,Gotoh D,Itami Y,Nakai Y,Anai S,Torimoto K,Tanaka N,Fujimoto K
Tue Oct 01 00:00:00 UTC 2019
Mutational activation of the epidermal growth factor receptor down-regulates major histocompatibility complex class I expression via the extracellular signal-regulated kinase in non-small cell lung cancer.
Cancer science
Watanabe S,Hayashi H,Haratani K,Shimizu S,Tanizaki J,Sakai K,Kawakami H,Yonesaka K,Tsurutani J,Togashi Y,Nishio K,Ito A,Nakagawa K
Tue Jan 01 00:00:00 UTC 2019
Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.
Cancer science
Harada K,Ihara F,Takami M,Kamata T,Mise N,Yoshizawa H,Hishiki T,Saito T,Terui K,Nakata M,Komatsu S,Ikeuchi T,Nakayama T,Yoshida H,Motohashi S
Fri Mar 01 00:00:00 UTC 2019
dPGS Regulates the Phenotype of Macrophages via Metabolic Switching.
Macromolecular bioscience
Wu H,Reimann S,Siddiqui S,Haag R,Siegmund B,Dernedde J,Glauben R
Sun Dec 01 00:00:00 UTC 2019
Targeted Migration of Human Adipose-Derived Stem Cells to Secondary Lymphoid Organs Enhances Their Immunomodulatory Effect and Prolongs the Survival of Allografted Vascularized Composites.
Stem cells (Dayton, Ohio)
Ma T,Luan S,Tao R,Lu D,Guo L,Liu J,Shu J,Zhou X,Han Y,Jia Y,Li G,Zhang H,Han W,Han Y,Li H
Sun Dec 01 00:00:00 UTC 2019
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Anderson W,Thorpe J,Long SA,Rawlings DJ
Sun Dec 15 00:00:00 UTC 2019
HBD3 Induces PD-L1 Expression on Head and Neck Squamous Cell Carcinoma Cell Lines.
Antibiotics (Basel, Switzerland)
Gomez Hernandez MP,Bates AM,Starman EE,Lanzel EA,Comnick C,Xie XJ,Brogden KA
300-02 was used in In vitro experiments to investigate human β-defensin 3 in head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Tue Sep 24 00:00:00 UTC 2019
Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes.
Experimental and therapeutic medicine
Lee HS,Park JW,Kwon OK,Lim Y,Kim JH,Kim SY,Zamora N,Rosales K,Choi S,Oh SR,Ahn KS
300-02 was used in Sample Preparation (ELISA) to investigate the therapeutic effects of C. odorata L. methanol extract on TNF-α and IFN-γ-stimulated HaCaT keratinocyte cells.
Mon Jul 01 00:00:00 UTC 2019
Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments.
The Journal of biological chemistry
Contreras-Baeza Y,Sandoval PY,Alarcón R,Galaz A,Cortés-Molina F,Alegría K,Baeza-Lehnert F,Arce-Molina R,Guequén A,Flores CA,San Martín A,Barros LF
Fri Dec 27 00:00:00 UTC 2019
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.
Nature communications
Takeda AJ,Maher TJ,Zhang Y,Lanahan SM,Bucklin ML,Compton SR,Tyler PM,Comrie WA,Matsuda M,Olivier KN,Pittaluga S,McElwee JJ,Long Priel DA,Kuhns DB,Williams RL,Mustillo PJ,Wymann MP,Koneti Rao V,Lucas CL
Wed Sep 25 00:00:00 UTC 2019
The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro.
Scientific reports
Helbig KJ,Teh MY,Crosse KM,Monson EA,Smith M,Tran EN,Standish AJ,Morona R,Beard MR
Wed Oct 30 00:00:00 UTC 2019
Umbilical cord as a long-term source of activatable mesenchymal stromal cells for immunomodulation.
Stem cell research & therapy
Selich A,Zimmermann K,Tenspolde M,Dittrich-Breiholz O,von Kaisenberg C,Schambach A,Rothe M
Mon Sep 23 00:00:00 UTC 2019
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease.
Nature communications
Szabo PA,Levitin HM,Miron M,Snyder ME,Senda T,Yuan J,Cheng YL,Bush EC,Dogra P,Thapa P,Farber DL,Sims PA
Thu Oct 17 00:00:00 UTC 2019
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion.
Science advances
Johnston JM,Angyal A,Bauer RC,Hamby S,Suvarna SK,Baidžajevas K,Hegedus Z,Dear TN,Turner M,Wilson HL,Goodall AH,Rader DJ,Shoulders CC,Francis SE,Kiss-Toth E
300-02 was used in Cell Culture to suggest that a conserved, TRIB1-mediated mechanism drives foam cell formation in atherosclerotic plaque and that inhibiting mTRIB1 could be used therapeutically to reduce CHD.
Tue Oct 01 00:00:00 UTC 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 UTC 2019
Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ.
Frontiers in immunology
Zhuang X,Veltri DP,Long EO
300-02 was used in In vitro experiments to investigate guide RNA and other protein involvement in NK cells in leukemia relapse following hematopoietic stem cell transplant.
Thu Oct 22 00:00:00 UTC 2020
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.
Nature communications
Martínez-García JJ,Martínez-Banaclocha H,Angosto-Bazarra D,de Torre-Minguela C,Baroja-Mazo A,Alarcón-Vila C,Martínez-Alarcón L,Amores-Iniesta J,Martín-Sánchez F,Ercole GA,Martínez CM,González-Lisorge A,Fernández-Pacheco J,Martínez-Gil P,Adriouch S,Koch-Nolte F,Luján J,Acosta-Villegas F,Parrilla P,García-Palenciano C,Pelegrin P
Thu Jun 20 00:00:00 UTC 2019
The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1.
The Journal of biological chemistry
Bialas J,Boehm AN,Catone N,Aichem A,Groettrup M
Fri Mar 22 00:00:00 UTC 2019
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
Nature communications
Wu X,Lei C,Xia T,Zhong X,Yang Q,Shu HB
Wed Sep 11 00:00:00 UTC 2019
Proinflammatory profile of neonatal monocytes induced by microbial ligands is downmodulated by histamine.
Scientific reports
Branco ACCC,Pereira NZ,Yoshikawa FSY,Oliveira LMDS,Teixeira FME,Oliveira LM,Pietrobon AJ,Torrealba MP,de Lima JF,Duarte AJDS,Sato MN
Mon Sep 23 00:00:00 UTC 2019
Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.
Scientific reports
Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B
Mon Aug 05 00:00:00 UTC 2019
ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.
Cell death & disease
Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A
Mon Oct 07 00:00:00 UTC 2019
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation.
Scientific reports
Castellanos-Rubio A,Santin I,Olazagoitia-Garmendia A,Romero-Garmendia I,Jauregi-Miguel A,Legarda M,Bilbao JR
Tue Mar 12 00:00:00 UTC 2019
Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer.
Cancers
Pan MR,Wu CC,Kan JY,Li QL,Chang SJ,Wu CC,Li CL,Ou-Yang F,Hou MF,Yip HK,Luo CW
300-02 was used in In vitro experiments to find that focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase that regulates several cellular functions in different cells, has the potential to regulate tumor cells sensitized to CIK cells.
Mon Dec 30 00:00:00 UTC 2019
The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.
Scientific reports
Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW
Thu Jun 06 00:00:00 UTC 2019
The ubiquitin-like modifier FAT10 interferes with SUMO activation.
Nature communications
Aichem A,Sailer C,Ryu S,Catone N,Stankovic-Valentin N,Schmidtke G,Melchior F,Stengel F,Groettrup M
Tue Oct 01 00:00:00 UTC 2019
Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation.
Cell death & disease
Zhang H,Qiu SL,Tang QY,Zhou X,Zhang JQ,He ZY,Bai J,Li MH,Deng JM,Liang Y,Zhong XN
Thu Sep 12 00:00:00 UTC 2019
Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells.
Scientific reports
Shokri MR,Bozorgmehr M,Ghanavatinejad A,Falak R,Aleahmad M,Kazemnejad S,Shokri F,Zarnani AH
Wed Jul 10 00:00:00 UTC 2019
Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses.
Scientific reports
Song JY,Kang HJ,Ju HM,Park A,Park H,Hong JS,Kim CJ,Shim JY,Yu J,Choi J
Mon Apr 29 00:00:00 UTC 2019
Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection.
Scientific reports
Krisnawati DI,Liu YC,Lee YJ,Wang YT,Chen CL,Tseng PC,Lin CF
Fri Apr 05 00:00:00 UTC 2019
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.
The Journal of biological chemistry
Feng K,Deng F,Hu Z,Wang H,Ning YJ
Fri Jun 14 00:00:00 UTC 2019
Neratinib protects pancreatic beta cells in diabetes.
Nature communications
Ardestani A,Li S,Annamalai K,Lupse B,Geravandi S,Dobrowolski A,Yu S,Zhu S,Baguley TD,Surakattula M,Oetjen J,Hauberg-Lotte L,Herranz R,Awal S,Altenhofen D,Nguyen-Tran V,Joseph S,Schultz PG,Chatterjee AK,Rogers N,Tremblay MS,Shen W,Maedler K
Fri Nov 01 00:00:00 UTC 2019
Neratinib protects pancreatic beta cells in diabetes.
Nature communications
Ardestani A,Li S,Annamalai K,Lupse B,Geravandi S,Dobrowolski A,Yu S,Zhu S,Baguley TD,Surakattula M,Oetjen J,Hauberg-Lotte L,Herranz R,Awal S,Altenhofen D,Nguyen-Tran V,Joseph S,Schultz PG,Chatterjee AK,Rogers N,Tremblay MS,Shen W,Maedler K
Fri Nov 01 00:00:00 UTC 2019
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine.
Cell death & disease
Tian CQ,Chen L,Chen HD,Huan XJ,Hu JP,Shen JK,Xiong B,Wang YQ,Miao ZH
300-02 was used in In vitro experiments to investigate bromodomain and extra terminal domain regulation on the targeting of IDO1.
Fri Jul 19 00:00:00 UTC 2019
Novel Human Anti-PD-L1 mAbs Inhibit Immune-Independent Tumor Cell Growth and PD-L1 Associated Intracellular Signalling.
Scientific reports
Passariello M,D'Alise AM,Esposito A,Vetrei C,Froechlich G,Scarselli E,Nicosia A,De Lorenzo C
Wed Sep 11 00:00:00 UTC 2019
In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.
Scientific reports
Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B
Wed Feb 13 00:00:00 UTC 2019
Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication.
Scientific reports
Park MK,Cho H,Roh SW,Kim SJ,Myoung J
Wed Feb 20 00:00:00 UTC 2019
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Cell death & disease
Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A
Tue May 28 00:00:00 UTC 2019
Identification of stably expressed housekeeping miRNAs in endothelial cells and macrophages in an inflammatory setting.
Scientific reports
Link F,Krohn K,Schumann J
Wed Sep 04 00:00:00 UTC 2019
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Cell death & disease
Yuan J,Tan L,Yin Z,Zhu W,Tao K,Wang G,Shi W,Gao J
Tue Jun 11 00:00:00 UTC 2019
HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway.
Cell death & disease
Aljabri A,Vijayan V,Stankov M,Nikolin C,Figueiredo C,Blasczyk R,Becker JU,Linkermann A,Immenschuh S
Fri Mar 08 00:00:00 UTC 2019
Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.
Theranostics
Rodell CB,Ahmed MS,Garris CS,Pittet MJ,Weissleder R
300-02 was used in Cell Culture to describe the development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy.
Mon Sep 14 00:00:00 UTC 2020
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Nature communications
Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C
Tue Dec 10 00:00:00 UTC 2019
T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients.
Oncoimmunology
Viborg N,Ramskov S,Andersen RS,Sturm T,Fugmann T,Bentzen AK,Rafa VM,Straten PT,Svane IM,Met Ö,Hadrup SR
300-02 was used in Sample Preparation (FC/FACS) to identify T cell targets in breast cancer for future treatment options.
Tue Jan 12 00:00:00 UTC 2021
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.
Frontiers in immunology
Lara-Reyna S,Scambler T,Holbrook J,Wong C,Jarosz-Griffiths HH,Martinon F,Savic S,Peckham D,McDermott MF
300-02 was used in Cell Culture to investigate signalling pathways following cystic fibrosis transmembrane conductance regulator mutations.
Tue Oct 13 00:00:00 UTC 2020
Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase.
The Journal of biological chemistry
Jobin PG,Solis N,Machado Y,Bell PA,Kwon NH,Kim S,Overall CM,Butler GS
Fri Aug 30 00:00:00 UTC 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 UTC 2018
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.
Nature
Chen G,Huang AC,Zhang W,Zhang G,Wu M,Xu W,Yu Z,Yang J,Wang B,Sun H,Xia H,Man Q,Zhong W,Antelo LF,Wu B,Xiong X,Liu X,Guan L,Li T,Liu S,Yang R,Lu Y,Dong L,McGettigan S,Somasundaram R,Radhakrishnan R,Mills G,Lu Y,Kim J,Chen YH,Dong H,Zhao Y,Karakousis GC,Mitchell TC,Schuchter LM,Herlyn M,Wherry EJ,Xu X,Guo W
Wed Aug 01 00:00:00 UTC 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 UTC 2018
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
300-02 was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.
Thu Oct 04 00:00:00 UTC 2018
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.
Cell
Wroblewska A,Dhainaut M,Ben-Zvi B,Rose SA,Park ES,Amir ED,Bektesevic A,Baccarini A,Merad M,Rahman AH,Brown BD
Thu Nov 01 00:00:00 UTC 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 UTC 2018
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Immunity
Lian H,Zang R,Wei J,Ye W,Hu MM,Chen YD,Zhang XN,Guo Y,Lei CQ,Yang Q,Luo WW,Li S,Shu HB
Tue Sep 18 00:00:00 UTC 2018
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
Immunity
He W,Holtkamp S,Hergenhan SM,Kraus K,de Juan A,Weber J,Bradfield P,Grenier JMP,Pelletier J,Druzd D,Chen CS,Ince LM,Bierschenk S,Pick R,Sperandio M,Aurrand-Lions M,Scheiermann C
Tue Dec 18 00:00:00 UTC 2018
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.
Cancer cell
Tsoi J,Robert L,Paraiso K,Galvan C,Sheu KM,Lay J,Wong DJL,Atefi M,Shirazi R,Wang X,Braas D,Grasso CS,Palaskas N,Ribas A,Graeber TG
Mon May 14 00:00:00 UTC 2018
CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia.
The Journal of clinical investigation
Lewinsky H,Barak AF,Huber V,Kramer MP,Radomir L,Sever L,Orr I,Mirkin V,Dezorella N,Shapiro M,Cohen Y,Shvidel L,Seiffert M,Herishanu Y,Becker-Herman S,Shachar I
Mon Dec 03 00:00:00 UTC 2018
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
The Journal of clinical investigation
Chen HM,van der Touw W,Wang YS,Kang K,Mai S,Zhang J,Alsina-Beauchamp D,Duty JA,Mungamuri SK,Zhang B,Moran T,Flavell R,Aaronson S,Hu HM,Arase H,Ramanathan S,Flores R,Pan PY,Chen SH
Mon Dec 03 00:00:00 UTC 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 UTC 2018
Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.
Clinical cancer research : an official journal of the American Association for Cancer Research
L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST
300-02 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.
Sun Jul 15 00:00:00 UTC 2018
Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.
Proceedings of the National Academy of Sciences of the United States of America
Ilca FT,Neerincx A,Wills MR,de la Roche M,Boyle LH
Tue Oct 02 00:00:00 UTC 2018
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.
Cellular and molecular gastroenterology and hepatology
Wang Y,Kim R,Gunasekara DB,Reed MI,DiSalvo M,Nguyen DL,Bultman SJ,Sims CE,Magness ST,Allbritton NL
300-02 was used in In vitro experiments to show the in vitro human colon crypt array accurately mimicked the architecture, luminal accessibility, tissue polarity, cell migration, and cellular responses of in vivo intestinal crypts.
Mon Mar 18 00:00:00 UTC 2024
Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States.
Frontiers in immunology
Danziger O,Pupko T,Bacharach E,Ehrlich M
300-02 was used in Sample Preparation (FC/FACS) to investigate the effects of JAK-STAT signaling on tumor development and therapy efficacy.
Thu Feb 28 00:00:00 UTC 2019
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Frontiers in immunology
Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M
300-02 was used in In vitro experiments to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.
Mon Apr 08 00:00:00 UTC 2019
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Frontiers in immunology
Ohradanova-Repic A,Machacek C,Charvet C,Lager F,Le Roux D,Platzer R,Leksa V,Mitulovic G,Burkard TR,Zlabinger GJ,Fischer MB,Feuillet V,Renault G,Blüml S,Benko M,Suchanek M,Huppa JB,Matsuyama T,Cavaco-Paulo A,Bismuth G,Stockinger H
Fri Jun 14 00:00:00 UTC 2019
Multiple Autologous Bone Marrow-Derived CD271+ Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children.
Stem cells translational medicine
Milczarek O,Jarocha D,Starowicz-Filip A,Kwiatkowski S,Badyra B,Majka M
Mon Jan 01 00:00:00 UTC 2018
Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia.
Blood advances
Jalali S,Price-Troska T,Paludo J,Villasboas J,Kim HJ,Yang ZZ,Novak AJ,Ansell SM
Tue Aug 14 00:00:00 UTC 2018
Recombinant Adenovirus KGHV500 and CIK Cells Codeliver Anti-p21-Ras scFv for the Treatment of Gastric Cancer with Wild-Type Ras Overexpression.
Molecular therapy oncolytics
Wang M,Hong Y,Feng Q,Pan X,Song S,Cui J,Lei J,Fang H,Yang J
300-02 was used in Cell Culture to study the antitumor effects of the recombinant oncolytic adenovirus carried by cytokine-induced killer (CIK) cells on n human gastric SGC7901 cells that overexpress wild-type Ras.
Fri Dec 21 00:00:00 UTC 2018
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Journal of leukocyte biology
Kirchmeyer M,Servais FA,Hamdorf M,Nazarov PV,Ginolhac A,Halder R,Vallar L,Glanemann M,Rubie C,Lammert F,Kreis S,Behrmann I
Thu Nov 01 00:00:00 UTC 2018
A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.
Journal of enzyme inhibition and medicinal chemistry
Xu G,Wang T,Li Y,Huang Z,Wang X,Zheng J,Yang S,Fan Y,Xiang R
300-02 was used in In vitro experiments to discover a novel inhibitor of indoleamine 2,3-dioxygenase 1 with an increased potent activity compared with other inhibitors in clinical trials.
Sat Dec 01 00:00:00 UTC 2018
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Ringleb J,Strack E,Angioni C,Geisslinger G,Steinhilber D,Weigert A,Brüne B
Mon Jan 15 00:00:00 UTC 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 UTC 2018
LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Sharma A,Lawry SM,Klein BS,Wang X,Sherer NM,Zumwalde NA,Gumperz JE
Mon Oct 15 00:00:00 UTC 2018
miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling.
Oncology reports
Wu Q,Zhao Y,Sun Y,Yan X,Wang P
300-02 was used in Cell Culture to investigate the effects of miR-375 on programmed death 1 ligand 1 (PD-L1) expression in head and neck squamous cell carcinoma (HNSCC) and suggest that by attenuating PD-1/PD-L1 signaling, miR-375 may also serve as a modulator to increase the cell immune responses to HNSCC.
Thu Mar 01 00:00:00 UTC 2018
The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.
Cell death & disease
Gu Y,Ding X,Huang J,Xue M,Zhang J,Wang Q,Yu H,Wang Y,Zhao F,Wang H,Jin M,Wu Y,Zhang Y
Tue May 01 00:00:00 UTC 2018
Immunity drives TET1 regulation in cancer through NF-κB.
Science advances
Collignon E,Canale A,Al Wardi C,Bizet M,Calonne E,Dedeurwaerder S,Garaud S,Naveaux C,Barham W,Wilson A,Bouchat S,Hubert P,Van Lint C,Yull F,Sotiriou C,Willard-Gallo K,Noel A,Fuks F
300-02 was used in In vitro experiments to suggest a novel mode of regulation for TET1 in cancer and highlight a new paradigm in which the immune system can influence cancer cell epigenetics.
Fri Jun 01 00:00:00 UTC 2018
Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis.
Scientific reports
Di Domenico EG,Cavallo I,Bordignon V,Prignano G,Sperduti I,Gurtner A,Trento E,Toma L,Pimpinelli F,Capitanio B,Ensoli F
Thu Jun 28 00:00:00 UTC 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 UTC 2018
Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening.
Frontiers in pharmacology
Zhang G,Xing J,Wang Y,Wang L,Ye Y,Lu D,Zhao J,Luo X,Zheng M,Yan S
300-02 was used in Cell Culture to investigate IDO1 in the kynurenine pathway in T cell development.
Tue Sep 29 00:00:00 UTC 2020
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.
Cell death & disease
Yulis M,Quiros M,Hilgarth R,Parkos CA,Nusrat A
Fri Mar 09 00:00:00 UTC 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 UTC 2018
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.
EBioMedicine
Rhys HI,Dell'Accio F,Pitzalis C,Moore A,Norling LV,Perretti M
300-02 was used in In vitro experiments to present new mechanistic evidence underpinning the anti-inflammatory and anti-arthritic properties of neutrophil microvesicles.
Thu Mar 01 00:00:00 UTC 2018
Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-α and IFN-γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models.
Scientific reports
Allen H,Shraga-Heled N,Blumenfeld M,Dego-Ashto T,Fuchs-Telem D,Gilert A,Aberman Z,Ofir R
Fri Jan 12 00:00:00 UTC 2018
Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.
Scientific reports
Zardoya-Laguardia P,Blaschitz A,Hirschmugl B,Lang I,Herzog SA,Nikitina L,Gauster M,Häusler M,Cervar-Zivkovic M,Karpf E,Maghzal GJ,Stanley CP,Stocker R,Wadsack C,Frank S,Sedlmayr P
Tue Apr 03 00:00:00 UTC 2018
Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes.
Scientific reports
Domenis R,Cifù A,Quaglia S,Pistis C,Moretti M,Vicario A,Parodi PC,Fabris M,Niazi KR,Soon-Shiong P,Curcio F
Thu Sep 06 00:00:00 UTC 2018
C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.
Nature communications
Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM
Wed Jun 20 00:00:00 UTC 2018
TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.
Nature communications
Zhang HX,Xu ZS,Lin H,Li M,Xia T,Cui K,Wang SY,Li Y,Shu HB,Wang YY
Fri Aug 24 00:00:00 UTC 2018
MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis.
Cell death & disease
Zhang W,Yi X,An Y,Guo S,Li S,Song P,Chang Y,Zhang S,Gao T,Wang G,Li C
Tue May 01 00:00:00 UTC 2018
Cytokine-induced killer cells as a feasible adoptive immunotherapy for the treatment of lung cancer.
Cell death & disease
Chen D,Sha H,Hu T,Dong S,Zhang J,Liu S,Cao H,Ma R,Wu Y,Jing C,Wang Z,Wu J,Feng J
Tue Mar 06 00:00:00 UTC 2018
Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch.
Scientific reports
Cheatham AM,Davis SE,Khatua AK,Popik W
Thu Jun 07 00:00:00 UTC 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Nature communications
Schubert M,Klinger B,Klünemann M,Sieber A,Uhlitz F,Sauer S,Garnett MJ,Blüthgen N,Saez-Rodriguez J
Tue Jan 02 00:00:00 UTC 2018
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Nature communications
Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH
Fri Sep 14 00:00:00 UTC 2018
A dynamic transcriptomic atlas of cytokine-induced killer cells.
The Journal of biological chemistry
Meng M,Li L,Li R,Wang W,Chen Y,Xie Y,Han R,Zhu K,Huang W,Yang L,Li S,Shi J,Tan W,Gao H,Zhao Y,Yang L,Tan J,Hou Z
Fri Dec 21 00:00:00 UTC 2018
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.
Scientific reports
Silvola JMU,Li XG,Virta J,Marjamäki P,Liljenbäck H,Hytönen JP,Tarkia M,Saunavaara V,Hurme S,Palani S,Hakovirta H,Ylä-Herttuala S,Saukko P,Chen Q,Low PS,Knuuti J,Saraste A,Roivainen A
Tue Jun 26 00:00:00 UTC 2018
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.
Nature communications
Schott K,Fuchs NV,Derua R,Mahboubi B,Schnellbächer E,Seifried J,Tondera C,Schmitz H,Shepard C,Brandariz-Nuñez A,Diaz-Griffero F,Reuter A,Kim B,Janssens V,König R
Fri Jun 08 00:00:00 UTC 2018
Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Stem cell reports
Idelson M,Alper R,Obolensky A,Yachimovich-Cohen N,Rachmilewitz J,Ejzenberg A,Beider E,Banin E,Reubinoff B
Tue Sep 11 00:00:00 UTC 2018
Integrin CD11b activation drives anti-tumor innate immunity.
Nature communications
Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA
Wed Dec 19 00:00:00 UTC 2018
Integrin CD11b activation drives anti-tumor innate immunity.
Nature communications
Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA
Wed Dec 19 00:00:00 UTC 2018
CDK4/6 inhibition triggers anti-tumour immunity.
Nature
Goel S,DeCristo MJ,Watt AC,BrinJones H,Sceneay J,Li BB,Khan N,Ubellacker JM,Xie S,Metzger-Filho O,Hoog J,Ellis MJ,Ma CX,Ramm S,Krop IE,Winer EP,Roberts TM,Kim HJ,McAllister SS,Zhao JJ
Thu Aug 24 00:00:00 UTC 2017
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Nature
Mezzadra R,Sun C,Jae LT,Gomez-Eerland R,de Vries E,Wu W,Logtenberg MEW,Slagter M,Rozeman EA,Hofland I,Broeks A,Horlings HM,Wessels LFA,Blank CU,Xiao Y,Heck AJR,Borst J,Brummelkamp TR,Schumacher TNM
Thu Sep 07 00:00:00 UTC 2017
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Nature
Wartewig T,Kurgyis Z,Keppler S,Pechloff K,Hameister E,Öllinger R,Maresch R,Buch T,Steiger K,Winter C,Rad R,Ruland J
Thu Dec 07 00:00:00 UTC 2017
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Cell
Gaidt MM,Ebert TS,Chauhan D,Ramshorn K,Pinci F,Zuber S,O'Duill F,Schmid-Burgk JL,Hoss F,Buhmann R,Wittmann G,Latz E,Subklewe M,Hornung V
Thu Nov 16 00:00:00 UTC 2017
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Cell
Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X
300-02 was used in In vitro experiments to identify STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral immunity and indicates potential of SETD2 in controlling viral infections.
Thu Jul 27 00:00:00 UTC 2017
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Blood
Tarafdar A,Hopcroft LE,Gallipoli P,Pellicano F,Cassels J,Hair A,Korfi K,Jørgensen HG,Vetrie D,Holyoake TL,Michie AM
Thu Jan 12 00:00:00 UTC 2017
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
The Journal of clinical investigation
Kim J,Park DY,Bae H,Park DY,Kim D,Lee CK,Song S,Chung TY,Lim DH,Kubota Y,Hong YK,He Y,Augustin HG,Oliver G,Koh GY
Mon Oct 02 00:00:00 UTC 2017
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
The Journal of experimental medicine
Young HL,Rowling EJ,Bugatti M,Giurisato E,Luheshi N,Arozarena I,Acosta JC,Kamarashev J,Frederick DT,Cooper ZA,Reuben A,Gil J,Flaherty KT,Wargo JA,Vermi W,Smith MP,Wellbrock C,Hurlstone A
Mon Jun 05 00:00:00 UTC 2017
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
The Journal of experimental medicine
Zhang Y,Ma CA,Lawrence MG,Break TJ,O'Connell MP,Lyons JJ,López DB,Barber JS,Zhao Y,Barber DL,Freeman AF,Holland SM,Lionakis MS,Milner JD
Mon Sep 04 00:00:00 UTC 2017
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
The Journal of experimental medicine
Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH
Mon Sep 04 00:00:00 UTC 2017
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
The Journal of experimental medicine
Rodero MP,Decalf J,Bondet V,Hunt D,Rice GI,Werneke S,McGlasson SL,Alyanakian MA,Bader-Meunier B,Barnerias C,Bellon N,Belot A,Bodemer C,Briggs TA,Desguerre I,Frémond ML,Hully M,van den Maagdenberg AMJM,Melki I,Meyts I,Musset L,Pelzer N,Quartier P,Terwindt GM,Wardlaw J,Wiseman S,Rieux-Laucat F,Rose Y,Neven B,Hertel C,Hayday A,Albert ML,Rozenberg F,Crow YJ,Duffy D
Mon May 01 00:00:00 UTC 2017
TRPM2-mediated rise in mitochondrial Zn2+ promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.
Cell death and differentiation
Li F,Munsey TS,Sivaprasadarao A
Fri Dec 01 00:00:00 UTC 2017
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Cell systems
Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS
300-02 was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.
Wed Apr 26 00:00:00 UTC 2017
Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-γ.
European journal of immunology
Dixon KO,O'Flynn J,Klar-Mohamad N,Daha MR,van Kooten C
Wed Mar 01 00:00:00 UTC 2017
IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.
Journal of immunology (Baltimore, Md. : 1950)
Victor AR,Nalin AP,Dong W,McClory S,Wei M,Mao C,Kladney RD,Youssef Y,Chan WK,Briercheck EL,Hughes T,Scoville SD,Pitarresi JR,Chen C,Manz S,Wu LC,Zhang J,Ostrowski MC,Freud AG,Leone GW,Caligiuri MA,Yu J
Sun Oct 01 00:00:00 UTC 2017
Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hutton AJ,Polak ME,Spalluto CM,Wallington JC,Pickard C,Staples KJ,Warner JA,Wilkinson TM
Sun Jan 01 00:00:00 UTC 2017
Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes.
Journal of immunology (Baltimore, Md. : 1950)
Leone DA,Peschel A,Brown M,Schachner H,Ball MJ,Gyuraszova M,Salzer-Muhar U,Fukuda M,Vizzardelli C,Bohle B,Rees AJ,Kain R
Sat Jul 15 00:00:00 UTC 2017
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Barik S,Ellis JS,Cascio JA,Miller MM,Ukah TK,Cattin-Roy AN,Zaghouani H
Sun Oct 01 00:00:00 UTC 2017
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
Journal of immunology (Baltimore, Md. : 1950)
Resheq YJ,Menzner AK,Bosch J,Tickle J,Li KK,Wilhelm A,Hepburn E,Murihead G,Ward ST,Curbishley SM,Zimmermann HW,Bruns T,Gilbert DF,Tripal P,Mackensen A,Adams DH,Weston CJ
Fri Sep 01 00:00:00 UTC 2017
Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.
Journal of cellular and molecular medicine
Darvin P,Joung YH,Kang DY,Sp N,Byun HJ,Hwang TS,Sasidharakurup H,Lee CH,Cho KH,Park KD,Lee HK,Yang YM
Sat Apr 01 00:00:00 UTC 2017
IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.
Scientific reports
Ovsiy I,Riabov V,Manousaridis I,Michel J,Moganti K,Yin S,Liu T,Sticht C,Kremmer E,Harmsen MC,Goerdt S,Gratchev A,Kzhyshkowska J
Mon Dec 04 00:00:00 UTC 2017
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
The Journal of biological chemistry
Cunha DA,Cito M,Grieco FA,Cosentino C,Danilova T,Ladrière L,Lindahl M,Domanskyi A,Bugliani M,Marchetti P,Eizirik DL,Cnop M
Fri Sep 08 00:00:00 UTC 2017
Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival.
The Journal of biological chemistry
Juan-Mateu J,Rech TH,Villate O,Lizarraga-Mollinedo E,Wendt A,Turatsinze JV,Brondani LA,Nardelli TR,Nogueira TC,Esguerra JLS,Alvelos MI,Marchetti P,Eliasson L,Eizirik DL
Fri Feb 24 00:00:00 UTC 2017
Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.
Scientific reports
Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T
Wed Aug 30 00:00:00 UTC 2017
Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.
Scientific reports
Holdsworth G,Bon H,Bergin M,Qureshi O,Paveley R,Atkinson J,Huang L,Tewari R,Twomey B,Johnson T
Wed Aug 30 00:00:00 UTC 2017
Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation.
Immunity, inflammation and disease
Shaw EJ,Smith EE,Whittingham-Dowd J,Hodges MD,Else KJ,Rigby RJ
Fri Sep 01 00:00:00 UTC 2017
Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation.
The Journal of biological chemistry
Fujiki R,Hijikata A,Shirai T,Okada S,Kobayashi M,Ohara O
Fri Apr 14 00:00:00 UTC 2017
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.
Scientific reports
Patten DA,Kamarajah SK,Rose JM,Tickle J,Shepherd EL,Adams DH,Weston CJ,Shetty S
Thu Dec 14 00:00:00 UTC 2017
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.
Scientific reports
Mayer U,Benditz A,Grässel S
Mon Oct 16 00:00:00 UTC 2017
Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.
Scientific reports
Sakakibara S,Arimori T,Yamashita K,Jinzai H,Motooka D,Nakamura S,Li S,Takeda K,Katayama J,El Hussien MA,Narazaki M,Tanaka T,Standley DM,Takagi J,Kikutani H
Mon Nov 27 00:00:00 UTC 2017
Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis.
Oncotarget
Tang WG,Hu B,Sun HX,Sun QM,Sun C,Fu PY,Yang ZF,Zhang X,Zhou CH,Fan J,Ren N,Xu Y
300-02 was used in Sample Preparation (Western Blotting) to use microarray to identify an interferon (IFN)-γ-induced long non-coding RNA (lncRNA) called LncRNA00364 in hepatocellular carcinoma (HCC).
Fri Nov 24 00:00:00 UTC 2017
MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells.
The Journal of biological chemistry
Yee D,Shah KM,Coles MC,Sharp TV,Lagos D
Fri Dec 15 00:00:00 UTC 2017
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
The Journal of biological chemistry
Riess M,Fuchs NV,Idica A,Hamdorf M,Flory E,Pedersen IM,König R
Fri Jan 06 00:00:00 UTC 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 UTC 2017
Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.
Cell death & disease
Zhang J,Zhang Y,Wu W,Wang F,Liu X,Shui G,Nie C
Thu Oct 26 00:00:00 UTC 2017
Nanosized UCMSC-derived extracellular vesicles but not conditioned medium exclusively inhibit the inflammatory response of stimulated T cells: implications for nanomedicine.
Theranostics
Monguió-Tortajada M,Roura S,Gálvez-Montón C,Pujal JM,Aran G,Sanjurjo L,Franquesa M,Sarrias MR,Bayes-Genis A,Borràs FE
300-02 was used in Cell Culture to highlight the importance of well-purified and defined preparations of MSC-derived EVs to achieve the immunosuppressive effect.
Fri Oct 20 00:00:00 UTC 2017
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.
The Journal of clinical investigation
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E
Tue Nov 01 00:00:00 UTC 2016
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.
Proceedings of the National Academy of Sciences of the United States of America
Brook M,Tomlinson GH,Miles K,Smith RW,Rossi AG,Hiemstra PS,van 't Wout EF,Dean JL,Gray NK,Lu W,Gray M
Tue Apr 19 00:00:00 UTC 2016
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.
Proceedings of the National Academy of Sciences of the United States of America
Gross CC,Schulte-Mecklenbeck A,Rünzi A,Kuhlmann T,Posevitz-Fejfár A,Schwab N,Schneider-Hohendorf T,Herich S,Held K,Konjević M,Hartwig M,Dornmair K,Hohlfeld R,Ziemssen T,Klotz L,Meuth SG,Wiendl H
Tue May 24 00:00:00 UTC 2016
SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes.
Experimental & molecular medicine
Ha YJ,Choi YS,Kang EH,Shin K,Kim TK,Song YW,Lee YJ
Fri Jun 24 00:00:00 UTC 2016
Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.
Experimental & molecular medicine
Hong CY,Lee HJ,Choi NR,Jung SH,Vo MC,Hoang MD,Kim HJ,Lee JJ
Fri Aug 19 00:00:00 UTC 2016
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.
Stem cells (Dayton, Ohio)
Barcellos-de-Souza P,Comito G,Pons-Segura C,Taddei ML,Gori V,Becherucci V,Bambi F,Margheri F,Laurenzana A,Del Rosso M,Chiarugi P
Sat Oct 01 00:00:00 UTC 2016
MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Kunert A,van Brakel M,van Steenbergen-Langeveld S,da Silva M,Coulie PG,Lamers C,Sleijfer S,Debets R
Thu Sep 15 00:00:00 UTC 2016
Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.
Journal of immunology (Baltimore, Md. : 1950)
Machacek C,Supper V,Leksa V,Mitulovic G,Spittler A,Drbal K,Suchanek M,Ohradanova-Repic A,Stockinger H
Thu Sep 15 00:00:00 UTC 2016
Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R.
Journal of immunology (Baltimore, Md. : 1950)
Do KH,Park SH,Kim J,Yu M,Moon Y
Mon Aug 01 00:00:00 UTC 2016
Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response.
Journal of immunology (Baltimore, Md. : 1950)
Peng N,Liu S,Xia Z,Ren S,Feng J,Jing M,Gao X,Wiemer EA,Zhu Y
Tue Mar 15 00:00:00 UTC 2016
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata.
Journal of immunology (Baltimore, Md. : 1950)
Dai Z,Xing L,Cerise J,Wang EH,Jabbari A,de Jong A,Petukhova L,Christiano AM,Clynes R
Mon Aug 15 00:00:00 UTC 2016
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A
Tue Nov 15 00:00:00 UTC 2016
IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.
Journal of immunology (Baltimore, Md. : 1950)
Popescu I,Pipeling MR,Mannem H,Shah PD,Orens JB,Connors M,Migueles SA,McDyer JF
Fri Jan 15 00:00:00 UTC 2016
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Galaine J,Kellermann G,Guillaume Y,Boidot R,Picard E,Loyon R,Queiroz L,Boullerot L,Beziaud L,Jary M,Mansi L,André C,Lethier L,Ségal-Bendirdjian E,Borg C,Godet Y,Adotévi O
Thu Sep 01 00:00:00 UTC 2016
Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells.
Journal of cellular and molecular medicine
Ah-Koon L,Lesage D,Lemadre E,Souissi I,Fagard R,Varin-Blank N,Fabre EE,Schischmanoff O
Sat Oct 01 00:00:00 UTC 2016
Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia.
Innate immunity
Erbel C,Rupp G,Domschke G,Linden F,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA
300-02 was used in Cell Culture to show that aldose reductase (AR) expression in macrophages is associated with atherosclerosis and diabetes, and that AR expression is increased under hyperglycaemic conditions.
Fri Apr 01 00:00:00 UTC 2016
TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein.
Scientific reports
Wang S,Chen Y,Li C,Wu Y,Guo L,Peng C,Huang Y,Cheng G,Qin FX
Wed Aug 31 00:00:00 UTC 2016
TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway.
Cell death & disease
Zhu X,Xie C,Li YM,Huang ZL,Zhao QY,Hu ZX,Wang PP,Gu YR,Gao ZL,Peng L
Thu Jun 02 00:00:00 UTC 2016
TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway.
Cell death & disease
Zhu X,Xie C,Li YM,Huang ZL,Zhao QY,Hu ZX,Wang PP,Gu YR,Gao ZL,Peng L
Thu Jun 02 00:00:00 UTC 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 UTC 2016
Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells.
The Journal of biological chemistry
Brozzi F,Gerlo S,Grieco FA,Juusola M,Balhuizen A,Lievens S,Gysemans C,Bugliani M,Mathieu C,Marchetti P,Tavernier J,Eizirik DL
Fri Jun 03 00:00:00 UTC 2016
Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus.
Scientific reports
Garcia J,Wright K,Roberts S,Kuiper JH,Mangham C,Richardson J,Mennan C
Wed Apr 13 00:00:00 UTC 2016
Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy.
Scientific reports
Gramlich OW,Burand AJ,Brown AJ,Deutsch RJ,Kuehn MH,Ankrum JA
Mon May 23 00:00:00 UTC 2016
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.
Scientific reports
Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M
Wed Nov 09 00:00:00 UTC 2016
miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.
Scientific reports
Wang Z,Xu L,Hu Y,Huang Y,Zhang Y,Zheng X,Wang S,Wang Y,Yu Y,Zhang M,Yuan K,Min W
Mon May 09 00:00:00 UTC 2016
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
Scientific reports
Yamada K,Miyamoto Y,Tsujii A,Moriyama T,Ikuno Y,Shiromizu T,Serada S,Fujimoto M,Tomonaga T,Naka T,Yoneda Y,Oka M
Thu Feb 18 00:00:00 UTC 2016
MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.
Scientific reports
Vagaska B,New SE,Alvarez-Gonzalez C,D'Acquisto F,Gomez SG,Bulstrode NW,Madrigal A,Ferretti P
Fri Apr 15 00:00:00 UTC 2016
Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR.
Oncotarget
Guo X,Xue H,Shao Q,Wang J,Guo X,Chen X,Zhang J,Xu S,Li T,Zhang P,Gao X,Qiu W,Liu Q,Li G
300-02 was used in Cell Culture to investigate tumour-associated macrophage infiltration on glioma.
Tue Dec 06 00:00:00 UTC 2016
Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.
The Journal of biological chemistry
Song X,Ding Y,Liu G,Yang X,Zhao R,Zhang Y,Zhao X,Anderson GJ,Nie G
Fri Apr 15 00:00:00 UTC 2016
Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway.
Scientific reports
Li D,Lei C,Xu Z,Yang F,Liu H,Zhu Z,Li S,Liu X,Shu H,Zheng H
Wed Feb 17 00:00:00 UTC 2016
Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway.
Scientific reports
Li D,Lei C,Xu Z,Yang F,Liu H,Zhu Z,Li S,Liu X,Shu H,Zheng H
Wed Feb 17 00:00:00 UTC 2016
Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.
Scientific reports
Zheng X,Ma S,Kang A,Wu M,Wang L,Wang Q,Wang G,Hao H
Tue Jan 19 00:00:00 UTC 2016
Gene Expression and Antiviral Activity of Interleukin-35 in Response to Influenza A Virus Infection.
The Journal of biological chemistry
Wang L,Zhu S,Xu G,Feng J,Han T,Zhao F,She YL,Liu S,Ye L,Zhu Y
Fri Aug 05 00:00:00 UTC 2016
Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function.
International journal of molecular medicine
Xie C,Liu C,Wu B,Lin Y,Ma T,Xiong H,Wang Q,Li Z,Ma C,Tu Z
300-02 was used in Cell Culture to provide a novel antitumor strategy for targeted cancer therapy.
Fri Jul 01 00:00:00 UTC 2016
Proteomic analysis uncovers common effects of IFN-γ and IL-27 on the HLA class I antigen presentation machinery in human cancer cells.
Oncotarget
Petretto A,Carbotti G,Inglese E,Lavarello C,Pistillo MP,Rigo V,Croce M,Longo L,Martini S,Vacca P,Ferrini S,Fabbi M
300-02 was used in In vitro experiments to add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation.
Tue Nov 08 00:00:00 UTC 2016
Bioelectric modulation of macrophage polarization.
Scientific reports
Li C,Levin M,Kaplan DL
Fri Feb 12 00:00:00 UTC 2016
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Scientific reports
Sommer AF,Rivière L,Qu B,Schott K,Riess M,Ni Y,Shepard C,Schnellbächer E,Finkernagel M,Himmelsbach K,Welzel K,Kettern N,Donnerhak C,Münk C,Flory E,Liese J,Kim B,Urban S,König R
Fri May 27 00:00:00 UTC 2016
Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration.
Scientific reports
Pfalzgraff A,Heinbockel L,Su Q,Gutsmann T,Brandenburg K,Weindl G
Thu Aug 11 00:00:00 UTC 2016
Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.
The Journal of biological chemistry
Hong K,Xu G,Grayson TB,Shalev A
Fri Apr 15 00:00:00 UTC 2016
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
The Journal of clinical investigation
Chen PY,Qin L,Baeyens N,Li G,Afolabi T,Budatha M,Tellides G,Schwartz MA,Simons M
Mon Oct 26 00:00:00 UTC 2015
Survivin-specific T cell receptor targets tumor but not T cells.
The Journal of clinical investigation
Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B
Thu Jan 01 00:00:00 UTC 2015
Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne muscular dystrophy.
EMBO molecular medicine
Cossu G,Previtali SC,Napolitano S,Cicalese MP,Tedesco FS,Nicastro F,Noviello M,Roostalu U,Natali Sora MG,Scarlato M,De Pellegrin M,Godi C,Giuliani S,Ciotti F,Tonlorenzi R,Lorenzetti I,Rivellini C,Benedetti S,Gatti R,Marktel S,Mazzi B,Tettamanti A,Ragazzi M,Imro MA,Marano G,Ambrosi A,Fiori R,Sormani MP,Bonini C,Venturini M,Politi LS,Torrente Y,Ciceri F
Tue Dec 01 00:00:00 UTC 2015
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Proceedings of the National Academy of Sciences of the United States of America
Hammarén HM,Ungureanu D,Grisouard J,Skoda RC,Hubbard SR,Silvennoinen O
Tue Apr 14 00:00:00 UTC 2015
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Proceedings of the National Academy of Sciences of the United States of America
Hammarén HM,Ungureanu D,Grisouard J,Skoda RC,Hubbard SR,Silvennoinen O
Tue Apr 14 00:00:00 UTC 2015
Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.
Proceedings of the National Academy of Sciences of the United States of America
Li X,Wang D,Chen Z,Lu E,Wang Z,Duan J,Tian W,Wang Y,You L,Zou Y,Cheng Y,Zhu Q,Wan X,Xi T,Jiang M,Han Y,Cao C,Birnbaumer L,Chu WM,Yang Y
Tue Apr 14 00:00:00 UTC 2015
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
The Journal of cell biology
Kimura T,Jain A,Choi SW,Mandell MA,Schroder K,Johansen T,Deretic V
Mon Sep 14 00:00:00 UTC 2015
Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A.
Journal of lipid research
Salvatore G,Bernoud-Hubac N,Bissay N,Debard C,Daira P,Meugnier E,Proamer F,Hanau D,Vidal H,Aricò M,Delprat C,Mahtouk K
Mon Jun 01 00:00:00 UTC 2015
Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells.
Stem cells (Dayton, Ohio)
Estève D,Boulet N,Volat F,Zakaroff-Girard A,Ledoux S,Coupaye M,Decaunes P,Belles C,Gaits-Iacovoni F,Iacovoni JS,Rémaury A,Castel B,Ferrara P,Heymes C,Lafontan M,Bouloumié A,Galitzky J
Wed Apr 01 00:00:00 UTC 2015
PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization.
Stem cells (Dayton, Ohio)
Mounayar M,Kefaloyianni E,Smith B,Solhjou Z,Maarouf OH,Azzi J,Chabtini L,Fiorina P,Kraus M,Briddell R,Fodor W,Herrlich A,Abdi R
Mon Jun 01 00:00:00 UTC 2015
The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Journal of immunology (Baltimore, Md. : 1950)
Pundir P,MacDonald CA,Kulka M
Tue Sep 15 00:00:00 UTC 2015
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
Journal of immunology (Baltimore, Md. : 1950)
Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D
Tue Sep 15 00:00:00 UTC 2015
Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.
Journal of immunology (Baltimore, Md. : 1950)
Ostrop J,Jozefowski K,Zimmermann S,Hofmann K,Strasser E,Lepenies B,Lang R
Tue Sep 01 00:00:00 UTC 2015
Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
McCully ML,Collins PJ,Hughes TR,Thomas CP,Billen J,O'Donnell VB,Moser B
Wed Jul 01 00:00:00 UTC 2015
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA
Thu Jan 15 00:00:00 UTC 2015
Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.
Journal of immunology (Baltimore, Md. : 1950)
Compan V,Martín-Sánchez F,Baroja-Mazo A,López-Castejón G,Gomez AI,Verkhratsky A,Brough D,Pelegrín P
Sun Feb 01 00:00:00 UTC 2015
A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
Journal of immunology (Baltimore, Md. : 1950)
White MJ,Galvis-Carvajal E,Gomer RH
Thu Jan 01 00:00:00 UTC 2015
Activated pancreatic stellate cells can impair pancreatic islet function in mice.
Upsala journal of medical sciences
Zang G,Sandberg M,Carlsson PO,Welsh N,Jansson L,Barbu A
300-02 was used in Cell Culture to investigate the morphology and relationships of pancreatic stellate cells and islets in mice.
Tue May 03 00:00:00 UTC 2016
Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Wu S,Xue J,Yang Y,Zhu H,Chen F,Wang J,Lou G,Liu Y,Shi Y,Yu Y,Xia C,Hu Y,Chen Z
300-02 was used in Cell Culture to study the effect of isoliquiritigenin (ISL) on the expression of genes induced by interferon-γ (IFN-γ) in vitro, and to elucidate the underlying molecular mechanisms involved in liver diseases.
Mon Jun 27 00:00:00 UTC 2016
MicroRNA-155-IFN-γ Feedback Loop in CD4(+)T Cells of Erosive type Oral Lichen Planus.
Scientific reports
Hu JY,Zhang J,Ma JZ,Liang XY,Chen GY,Lu R,Du GF,Zhou G
Mon Nov 23 00:00:00 UTC 2015
Multiple structural and epigenetic defects in the human leukocyte antigen class I antigen presentation pathway in a recurrent metastatic melanoma following immunotherapy.
The Journal of biological chemistry
Chang CC,Pirozzi G,Wen SH,Chung IH,Chiu BL,Errico S,Luongo M,Lombardi ML,Ferrone S
Fri Oct 30 00:00:00 UTC 2015
IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.
Blood cancer journal
Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM
Fri Jul 31 00:00:00 UTC 2015
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
Nature communications
Baruch K,Rosenzweig N,Kertser A,Deczkowska A,Sharif AM,Spinrad A,Tsitsou-Kampeli A,Sarel A,Cahalon L,Schwartz M
Tue Aug 18 00:00:00 UTC 2015
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.
Nature communications
Adoro S,Cubillos-Ruiz JR,Chen X,Deruaz M,Vrbanac VD,Song M,Park S,Murooka TT,Dudek TE,Luster AD,Tager AM,Streeck H,Bowman B,Walker BD,Kwon DS,Lazarevic V,Glimcher LH
Thu Jun 25 00:00:00 UTC 2015
Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.
Scientific reports
Becker M,De Bastiani MA,Parisi MM,Guma FT,Markoski MM,Castro MA,Kaplan MH,Barbé-Tuana FM,Klamt F
Tue Aug 25 00:00:00 UTC 2015
Differentiation of THP1 Cells into Macrophages for Transwell Co-culture Assay with Melanoma Cells.
Bio-protocol
Smith MP,Young H,Hurlstone A,Wellbrock C
300-02 was used in In vitro experiments to study the effects of the macrophage secretome on cancer cells (on e.g. growth, drug response or gene expression) in co-cultures without direct cell contact interactions.
Mon May 11 00:00:00 UTC 2015
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Nature communications
Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E
Mon Oct 05 00:00:00 UTC 2015
Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.
Scientific reports
Kumai T,Ohkuri T,Nagato T,Matsuda Y,Oikawa K,Aoki N,Kimura S,Celis E,Harabuchi Y,Kobayashi H
Thu Nov 05 00:00:00 UTC 2015
Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.
Scientific reports
Kumai T,Ohkuri T,Nagato T,Matsuda Y,Oikawa K,Aoki N,Kimura S,Celis E,Harabuchi Y,Kobayashi H
Thu Nov 05 00:00:00 UTC 2015
Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.
Scientific reports
Kumai T,Ohkuri T,Nagato T,Matsuda Y,Oikawa K,Aoki N,Kimura S,Celis E,Harabuchi Y,Kobayashi H
Thu Nov 05 00:00:00 UTC 2015
Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.
Scientific reports
Zhu H,Wan X,Li J,Han L,Bo X,Chen W,Lu C,Shen Z,Xu C,Chen L,Yu C,Xu G
Fri Jul 17 00:00:00 UTC 2015
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Nature communications
Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M
Wed Nov 04 00:00:00 UTC 2015
Mica Nanoparticle, STB-HO Eliminates the Human Breast Carcinoma Cells by Regulating the Interaction of Tumor with its Immune Microenvironment.
Scientific reports
Kang TW,Kim HS,Lee BC,Shin TH,Choi SW,Kim YJ,Lee HY,Jung YK,Seo KW,Kang KS
Thu Dec 03 00:00:00 UTC 2015
Galectin-1 regulates tissue exit of specific dendritic cell populations.
The Journal of biological chemistry
Thiemann S,Man JH,Chang MH,Lee B,Baum LG
Fri Sep 11 00:00:00 UTC 2015
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 UTC 2014
Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells.
Nature protocols
Wölfl M,Greenberg PD
300-02 was used in Cell Culture to develop an assay for antigen-specific priming of CD8(+) T cells after a single specific stimulation event.
Tue Apr 01 00:00:00 UTC 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
Fri Aug 01 00:00:00 UTC 2014
Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow.
Molecular therapy : the journal of the American Society of Gene Therapy
Lin P,Correa D,Kean TJ,Awadallah A,Dennis JE,Caplan AI
Wed Jan 01 00:00:00 UTC 2014
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Sundberg TB,Choi HG,Song JH,Russell CN,Hussain MM,Graham DB,Khor B,Gagnon J,O'Connell DJ,Narayan K,Dančík V,Perez JR,Reinecker HC,Gray NS,Schreiber SL,Xavier RJ,Shamji AF
Tue Aug 26 00:00:00 UTC 2014
Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proceedings of the National Academy of Sciences of the United States of America
Brennan PJ,Tatituri RV,Heiss C,Watts GF,Hsu FF,Veerapen N,Cox LR,Azadi P,Besra GS,Brenner MB
Tue Sep 16 00:00:00 UTC 2014
Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody. A potential strategy to enhance anti-TNF therapy.
mAbs
Hristodorov D,Mladenov R,Brehm H,Fischer R,Barth S,Thepen T
300-02 was used in Cell Culture to demonstrate the specific blocking of CD64 by H22(scFv) could be used as a mechanism for potentiating the effect of anti-TNF antibodies.
Mon Aug 24 00:00:00 UTC 2015
Endothelial microparticles interact with and support the proliferation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wheway J,Latham SL,Combes V,Grau GE
Wed Oct 01 00:00:00 UTC 2014
Endothelial microparticles interact with and support the proliferation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wheway J,Latham SL,Combes V,Grau GE
Wed Oct 01 00:00:00 UTC 2014
Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950)
Herter S,Birk MC,Klein C,Gerdes C,Umana P,Bacac M
Sat Mar 01 00:00:00 UTC 2014
Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
Wang YC,Chen CL,Sheu BS,Yang YJ,Tseng PC,Hsieh CY,Lin CF
Wed Oct 15 00:00:00 UTC 2014
Haplotypes of FcγRIIa and FcγRIIIb polymorphic variants influence IgG-mediated responses in neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
van der Heijden J,Nagelkerke S,Zhao X,Geissler J,Rispens T,van den Berg TK,Kuijpers TW
Sat Mar 15 00:00:00 UTC 2014
Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Ohshima J,Lee Y,Sasai M,Saitoh T,Su Ma J,Kamiyama N,Matsuura Y,Pann-Ghill S,Hayashi M,Ebisu S,Takeda K,Akira S,Yamamoto M
Tue Apr 01 00:00:00 UTC 2014
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C
Wed Jan 01 00:00:00 UTC 2014
The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y
Tue Jul 01 00:00:00 UTC 2014
Functional characterization of ocular-derived human alphaherpesvirus cross-reactive CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ouwendijk WJ,Geluk A,Smits SL,Getu S,Osterhaus AD,Verjans GM
Tue Apr 15 00:00:00 UTC 2014
Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.
Journal of immunology (Baltimore, Md. : 1950)
Kis-Toth K,Tsokos GC
Thu May 01 00:00:00 UTC 2014
Tumor-derived α-fetoprotein impairs the differentiation and T cell stimulatory activity of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Pardee AD,Shi J,Butterfield LH
Mon Dec 01 00:00:00 UTC 2014
IL-32 promotes angiogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Nold-Petry CA,Rudloff I,Baumer Y,Ruvo M,Marasco D,Botti P,Farkas L,Cho SX,Zepp JA,Azam T,Dinkel H,Palmer BE,Boisvert WA,Cool CD,Taraseviciene-Stewart L,Heinhuis B,Joosten LA,Dinarello CA,Voelkel NF,Nold MF
Wed Jan 15 00:00:00 UTC 2014
Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.
Journal of immunology (Baltimore, Md. : 1950)
Cupi ML,Sarra M,Marafini I,Monteleone I,Franzè E,Ortenzi A,Colantoni A,Sica G,Sileri P,Rosado MM,Carsetti R,MacDonald TT,Pallone F,Monteleone G
Sun Jun 15 00:00:00 UTC 2014
Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.
The Journal of biological chemistry
Sokolowska M,Chen LY,Eberlein M,Martinez-Anton A,Liu Y,Alsaaty S,Qi HY,Logun C,Horton M,Shelhamer JH
Fri Feb 14 00:00:00 UTC 2014
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
300-02 was used in Cell Culture to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 UTC 2015
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
300-02 was used in Cell Culture to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 UTC 2015
Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.
The Journal of biological chemistry
He L,Marneros AG
Fri Mar 21 00:00:00 UTC 2014
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
The Journal of biological chemistry
Brozzi F,Gerlo S,Grieco FA,Nardelli TR,Lievens S,Gysemans C,Marselli L,Marchetti P,Mathieu C,Tavernier J,Eizirik DL
Fri Jul 25 00:00:00 UTC 2014
A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.
The Journal of biological chemistry
Moll HP,Lee A,Minussi DC,da Silva CG,Csizmadia E,Bhasin M,Ferran C
Fri Nov 07 00:00:00 UTC 2014
Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.
The Journal of biological chemistry
Hanihara-Tatsuzawa F,Miura H,Kobayashi S,Isagawa T,Okuma A,Manabe I,MaruYama T
Fri Nov 07 00:00:00 UTC 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 UTC 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 UTC 2014
Regulation of activation-associated microRNA accumulation rates during monocyte-to-macrophage differentiation.
The Journal of biological chemistry
Eigsti RL,Sudan B,Wilson ME,Graff JW
Fri Oct 10 00:00:00 UTC 2014
Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory T cells.
Journal of translational medicine
Ye W,Xing Y,Paustian C,van de Ven R,Moudgil T,Hilton TL,Fox BA,Urba WJ,Zhao W,Hu HM
300-02 was used in Cell Culture to examine the activity of Defective ribosomal products in blebs (DRibbles) in humans.
Wed Apr 16 00:00:00 UTC 2014
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Scientific reports
Chen CF,Feng X,Liao HY,Jin WJ,Zhang J,Wang Y,Gong LL,Liu JJ,Yuan XH,Zhao BB,Zhang D,Chen GF,Wan Y,Guo J,Yan HP,He YW
Mon Sep 15 00:00:00 UTC 2014
A reversible gene trap collection empowers haploid genetics in human cells.
Nature methods
Bürckstümmer T,Banning C,Hainzl P,Schobesberger R,Kerzendorfer C,Pauler FM,Chen D,Them N,Schischlik F,Rebsamen M,Smida M,Fece de la Cruz F,Lapao A,Liszt M,Eizinger B,Guenzl PM,Blomen VA,Konopka T,Gapp B,Parapatics K,Maier B,Stöckl J,Fischl W,Salic S,Taba Casari MR,Knapp S,Bennett KL,Bock C,Colinge J,Kralovics R,Ammerer G,Casari G,Brummelkamp TR,Superti-Furga G,Nijman SM
Tue Oct 01 00:00:00 UTC 2013
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
Immunity
Obermoser G,Presnell S,Domico K,Xu H,Wang Y,Anguiano E,Thompson-Snipes L,Ranganathan R,Zeitner B,Bjork A,Anderson D,Speake C,Ruchaud E,Skinner J,Alsina L,Sharma M,Dutartre H,Cepika A,Israelsson E,Nguyen P,Nguyen QA,Harrod AC,Zurawski SM,Pascual V,Ueno H,Nepom GT,Quinn C,Blankenship D,Palucka K,Banchereau J,Chaussabel D
Thu Apr 18 00:00:00 UTC 2013
Human iPS cell-derived hematopoietic progenitor cells induce T-cell anergy in in vitro-generated alloreactive CD8(+) T cells.
Blood
Kim EM,Manzar G,Zavazava N
Thu Jun 27 00:00:00 UTC 2013
An analysis of the function and expression of D6 on lymphatic endothelial cells.
Blood
McKimmie CS,Singh MD,Hewit K,Lopez-Franco O,Le Brocq M,Rose-John S,Lee KM,Baker AH,Wheat R,Blackbourn DJ,Nibbs RJ,Graham GJ
Thu May 02 00:00:00 UTC 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 UTC 2013
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.
The Journal of experimental medicine
Kotlarz D,Ziętara N,Uzel G,Weidemann T,Braun CJ,Diestelhorst J,Krawitz PM,Robinson PN,Hecht J,Puchałka J,Gertz EM,Schäffer AA,Lawrence MG,Kardava L,Pfeifer D,Baumann U,Pfister ED,Hanson EP,Schambach A,Jacobs R,Kreipe H,Moir S,Milner JD,Schwille P,Mundlos S,Klein C
Mon Mar 11 00:00:00 UTC 2013
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H
Tue Jan 15 00:00:00 UTC 2013
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models.
Molecular cancer therapeutics
Herter S,Herting F,Mundigl O,Waldhauer I,Weinzierl T,Fauti T,Muth G,Ziegler-Landesberger D,Van Puijenbroek E,Lang S,Duong MN,Reslan L,Gerdes CA,Friess T,Baer U,Burtscher H,Weidner M,Dumontet C,Umana P,Niederfellner G,Bacac M,Klein C
300-02 was used in Sample Preparation (FC/FACS) to show that the glyoengineered type II CD20 antibody GA101 is differentiated from the two approved type I CD20 antibodies rituximab and ofatumumab by its overall preclinical activity, further supporting its clinical investigation.
Tue Oct 01 00:00:00 UTC 2013
Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1.
Journal of immunology (Baltimore, Md. : 1950)
Gao B,Wang Y,Xu W,Li S,Li Q,Xiong S
Mon Jul 01 00:00:00 UTC 2013
Evidence for postinitiation regulation of mRNA biogenesis in tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Salamon H,Qiao Y,Cheng JC,Yamaguchi KD,Soteropoulos P,Weiden M,Gennaro ML,Pine R
Fri Mar 15 00:00:00 UTC 2013
Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Hagberg N,Theorell J,Schlums H,Eloranta ML,Bryceson YT,Rönnblom L
Sun Sep 15 00:00:00 UTC 2013
SOCS3 regulates BAFF in human enterocytes under ribosomal stress.
Journal of immunology (Baltimore, Md. : 1950)
Do KH,Choi HJ,Kim J,Park SH,Kim KH,Moon Y
Sat Jun 15 00:00:00 UTC 2013
The road to memory: an early rest for the long journey.
Journal of immunology (Baltimore, Md. : 1950)
Ho LP,Yit PS,Ng LH,Linn YC,Zhao Y,Sun L,Ling KL,Chai Koh MB,Monica Shih MC,Li S,Wang XY,Tien SL,Goh YT
Sun Dec 01 00:00:00 UTC 2013
Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Matsumoto T,Hasegawa H,Onishi S,Ishizaki J,Suemori K,Yasukawa M
Sun Sep 01 00:00:00 UTC 2013
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M
Wed May 01 00:00:00 UTC 2013
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950)
Van Rompaey L,Galien R,van der Aar EM,Clement-Lacroix P,Nelles L,Smets B,Lepescheux L,Christophe T,Conrath K,Vandeghinste N,Vayssiere B,De Vos S,Fletcher S,Brys R,van 't Klooster G,Feyen JH,Menet C
Tue Oct 01 00:00:00 UTC 2013
Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.
Journal of immunology (Baltimore, Md. : 1950)
Eigenbrod T,Bode KA,Dalpke AH
Sat Jun 15 00:00:00 UTC 2013
Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Sohlberg E,Saghafian-Hedengren S,Rasul E,Marchini G,Nilsson C,Klein E,Nagy N,Sverremark-Ekström E
Sun Dec 01 00:00:00 UTC 2013
Enzymatic discovery of a HER-2/neu epitope that generates cross-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950)
Henle AM,Erskine CL,Benson LM,Clynes R,Knutson KL
Tue Jan 01 00:00:00 UTC 2013
PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Chang HH,Miaw SC,Tseng W,Sun YW,Liu CC,Tsao HW,Ho IC
Sun Sep 01 00:00:00 UTC 2013
A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
PloS one
Ucero AC,Berzal S,Ocaña-Salceda C,Sancho M,Orzáez M,Messeguer A,Ruiz-Ortega M,Egido J,Vicent MJ,Ortiz A,Ramos AM
Tue Aug 20 00:00:00 UTC 2013
Chemoresistance of human monocyte-derived dendritic cells is regulated by IL-17A.
PloS one
Olsson Åkefeldt S,Maisse C,Belot A,Mazzorana M,Salvatore G,Bissay N,Jurdic P,Aricò M,Rabourdin-Combe C,Henter JI,Delprat C
Tue Aug 13 00:00:00 UTC 2013
Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells.
Oncoimmunology
Sapkota B,Hill CE,Pollack BP
Tue Jan 01 00:00:00 UTC 2013
JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations.
Scientific reports
Ren Y,Zhang Y,Liu RZ,Fenstermacher DA,Wright KL,Teer JK,Wu J
Thu Oct 24 00:00:00 UTC 2013
Oral administration of transforming growth factor-β1 (TGF-β1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor κB (NF-κB) signaling and proinflammatory cytokine production.
The Journal of biological chemistry
Shiou SR,Yu Y,Guo Y,Westerhoff M,Lu L,Petrof EO,Sun J,Claud EC
Fri Nov 29 00:00:00 UTC 2013
Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1).
The Journal of biological chemistry
Li Y,Xie J,Xu X,Liu L,Wan Y,Liu Y,Zhu C,Zhu Y
Fri Jul 19 00:00:00 UTC 2013
The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.
PloS one
Szabo A,Gogolak P,Pazmandi K,Kis-Toth K,Riedl K,Wizel B,Lingnau K,Bacsi A,Rethi B,Rajnavolgyi E
Mon Dec 02 00:00:00 UTC 2013
Human retinal pigment epithelial cells express the long pentraxin PTX3.
Molecular vision
Woo JM,Kwon MY,Shin DY,Kang YH,Hwang N,Chung SW
Fri Sep 06 00:00:00 UTC 2013
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Nature
Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T
Thu Oct 18 00:00:00 UTC 2012
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation.
Blood
Weissmüller S,Semmler LY,Kalinke U,Christians S,Müller-Berghaus J,Waibler Z
Thu Jun 28 00:00:00 UTC 2012
The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34(+) stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin.
Cellular & molecular immunology
Proietto AI,Mittag D,Roberts AW,Sprigg N,Wu L
Thu Nov 01 00:00:00 UTC 2012
Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment.
The Journal of clinical investigation
Tarek N,Le Luduec JB,Gallagher MM,Zheng J,Venstrom JM,Chamberlain E,Modak S,Heller G,Dupont B,Cheung NK,Hsu KC
Sat Sep 01 00:00:00 UTC 2012
EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.
The Journal of clinical investigation
White RE,Rämer PC,Naresh KN,Meixlsperger S,Pinaud L,Rooney C,Savoldo B,Coutinho R,Bödör C,Gribben J,Ibrahim HA,Bower M,Nourse JP,Gandhi MK,Middeldorp J,Cader FZ,Murray P,Münz C,Allday MJ
Sun Apr 01 00:00:00 UTC 2012
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
The Journal of experimental medicine
Hirschhorn-Cymerman D,Budhu S,Kitano S,Liu C,Zhao F,Zhong H,Lesokhin AM,Avogadri-Connors F,Yuan J,Li Y,Houghton AN,Merghoub T,Wolchok JD
Mon Oct 22 00:00:00 UTC 2012
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.
The Journal of experimental medicine
Theocharides AP,Jin L,Cheng PY,Prasolava TK,Malko AV,Ho JM,Poeppl AG,van Rooijen N,Minden MD,Danska JS,Dick JE,Wang JC
Mon Sep 24 00:00:00 UTC 2012
Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Proceedings of the National Academy of Sciences of the United States of America
Ashraf SQ,Nicholls AM,Wilding JL,Ntouroupi TG,Mortensen NJ,Bodmer WF
Tue Dec 18 00:00:00 UTC 2012
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
Journal of molecular medicine (Berlin, Germany)
Eaton A,Nagy E,Pacault M,Fauconnier J,Bäck M
Mon Oct 01 00:00:00 UTC 2012
Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.
Laboratory investigation; a journal of technical methods and pathology
Tsakiris I,Torocsik D,Gyongyosi A,Dozsa A,Szatmari I,Szanto A,Soos G,Nemes Z,Igali L,Marton I,Takats Z,Nagy L,Dezso B
Thu Mar 01 00:00:00 UTC 2012
Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura H,Kobayashi M,Wakita D,Nishimura T
Tue May 01 00:00:00 UTC 2012
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Agbanoma G,Li C,Ennis D,Palfreeman AC,Williams LM,Brennan FM
Wed Feb 01 00:00:00 UTC 2012
Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Meda C,Molla F,De Pizzol M,Regano D,Maione F,Capano S,Locati M,Mantovani A,Latini R,Bussolino F,Giraudo E
Sun Apr 15 00:00:00 UTC 2012
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM
Sat Dec 01 00:00:00 UTC 2012
Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Ioannou M,Alissafi T,Lazaridis I,Deraos G,Matsoukas J,Gravanis A,Mastorodemos V,Plaitakis A,Sharpe A,Boumpas D,Verginis P
Wed Feb 01 00:00:00 UTC 2012
Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model.
Human molecular genetics
Tomassini B,Arcuri G,Fortuni S,Sandi C,Ezzatizadeh V,Casali C,Condò I,Malisan F,Al-Mahdawi S,Pook M,Testi R
Sun Jul 01 00:00:00 UTC 2012
Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors.
PloS one
Belderbos ME,Levy O,Stalpers F,Kimpen JL,Meyaard L,Bont L
Mon Jul 23 00:00:00 UTC 2012
A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen.
PloS one
Zhao RY,Mifsud NA,Xiao K,Chan KF,Oveissi S,Jackson HM,Dimopoulos N,Guillaume P,Knights AJ,Lowen T,Robson NC,Russell SE,Scotet E,Davis ID,Maraskovsky E,Cebon J,Luescher IF,Chen W
Thu Mar 07 00:00:00 UTC 2013
Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.
The Journal of biological chemistry
Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T
Fri Jul 20 00:00:00 UTC 2012
Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.
PloS one
van Lierop MJ,Alkema W,Laskewitz AJ,Dijkema R,van der Maaden HM,Smit MJ,Plate R,Conti PG,Jans CG,Timmers CM,van Boeckel CA,Lusher SJ,McGuire R,van Schaik RC,de Vlieg J,Smeets RL,Hofstra CL,Boots AM,van Duin M,Ingelse BA,Schoonen WG,Grefhorst A,van Dijk TH,Kuipers F,Dokter WH
Wed May 01 00:00:00 UTC 2013
Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.
The Journal of biological chemistry
Panter MS,Jain A,Leonhardt RM,Ha T,Cresswell P
Fri Sep 07 00:00:00 UTC 2012
Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors.
The Journal of biological chemistry
Comas-Casellas E,Martínez-Barriocanal Á,Miró F,Ejarque-Ortiz A,Schwartz S,Martín M,Sayós J
Fri Mar 23 00:00:00 UTC 2012
TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.
Clinical & developmental immunology
Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R
Fri Mar 01 00:00:00 UTC 2013
Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer.
BMC cancer
Fleming JM,Ginsburg E,Oliver SD,Goldsmith P,Vonderhaar BK
Fri Jun 22 00:00:00 UTC 2012
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 UTC 2012
Oxidative stress induced interleukin-32 mRNA expression in human bronchial epithelial cells.
Respiratory research
Kudo M,Ogawa E,Kinose D,Haruna A,Takahashi T,Tanabe N,Marumo S,Hoshino Y,Hirai T,Sakai H,Muro S,Date H,Mishima M
Wed Mar 14 00:00:00 UTC 2012
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.
PloS one
Zhao T,Gao S,Wang X,Liu J,Duan Y,Yuan Z,Sheng J,Li S,Wang F,Yu M,Ren H,Hao J
Tue Feb 19 00:00:00 UTC 2013
Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades.
Molecular cancer
Kunigal S,Ponnusamy MP,Momi N,Batra SK,Chellappan SP
Thu Apr 26 00:00:00 UTC 2012
IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
The Journal of biological chemistry
Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H
Fri Dec 07 00:00:00 UTC 2012
Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.
PloS one
Choi NM,Boss JM
Thu Oct 18 00:00:00 UTC 2012
Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways.
BMC microbiology
Yang YJ,Chuang CC,Yang HB,Lu CC,Sheu BS
Mon Mar 19 00:00:00 UTC 2012
Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways.
BMC microbiology
Yang YJ,Chuang CC,Yang HB,Lu CC,Sheu BS
Mon Mar 19 00:00:00 UTC 2012
Genome-wide RNAi screen in IFN-γ-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis.
PloS one
Zhou H,DeLoid G,Browning E,Gregory DJ,Tan F,Bedugnis AS,Imrich A,Koziel H,Kramnik I,Lu Q,Kobzik L
Fri Aug 03 00:00:00 UTC 2012
Identifying functional microRNAs in macrophages with polarized phenotypes.
The Journal of biological chemistry
Graff JW,Dickson AM,Clay G,McCaffrey AP,Wilson ME
Fri Jun 22 00:00:00 UTC 2012
The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ.
Journal of neuroinflammation
Hashioka S,Klegeris A,McGeer PL
Wed May 30 00:00:00 UTC 2012
A study of mifepristone/IFN-γ-induced apoptosis of human cholangiocarcinoma cell line FRH-0201 in vitro.
OncoTargets and therapy
Sun QL,Zhang XG,Xing QT,Ding P,Feng JB,Wu XP,Wang ZM
Wed Nov 28 00:00:00 UTC 2012
A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation.
PloS one
Guo CJ,Yang LS,Zhang YF,Wu YY,Weng SP,Yu XQ,He JG
Wed Nov 28 00:00:00 UTC 2012
A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation.
PloS one
Guo CJ,Yang LS,Zhang YF,Wu YY,Weng SP,Yu XQ,He JG
Wed Nov 28 00:00:00 UTC 2012
A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation.
PloS one
Guo CJ,Yang LS,Zhang YF,Wu YY,Weng SP,Yu XQ,He JG
Wed Nov 28 00:00:00 UTC 2012
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
PloS one
Suh HS,Choi N,Tarassishin L,Lee SC
Tue Aug 07 00:00:00 UTC 2012
Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy.
PloS one
Jin WJ,Chen CF,Liao HY,Gong LL,Yuan XH,Zhao BB,Zhang D,Feng X,Liu JJ,Wang Y,Chen GF,Yan HP,He YW
Mon Aug 20 00:00:00 UTC 2012
Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model.
PloS one
Yang Z,Zhang Q,Xu K,Shan J,Shen J,Liu L,Xu Y,Xia F,Bie P,Zhang X,Cui Y,Bian XW,Qian C
Tue Mar 05 00:00:00 UTC 2013
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.
Immunity
Chae JJ,Cho YH,Lee GS,Cheng J,Liu PP,Feigenbaum L,Katz SI,Kastner DL
Fri May 27 00:00:00 UTC 2011
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity
Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A
Fri Dec 23 00:00:00 UTC 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 UTC 2011
The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib.
Blood
Meyer dos Santos S,Klinkhardt U,Scholich K,Nelson K,Monsefi N,Deckmyn H,Kuczka K,Zorn A,Harder S
Thu May 05 00:00:00 UTC 2011
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
Thu Sep 01 00:00:00 UTC 2011
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood
Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F
Thu Mar 17 00:00:00 UTC 2011
Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.
Blood
Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R
Thu Aug 18 00:00:00 UTC 2011
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
The Journal of clinical investigation
Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K
Tue Mar 01 00:00:00 UTC 2011
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.
The Journal of experimental medicine
Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Nonoyama S,Karasuyama H,Minegishi Y
Mon Feb 14 00:00:00 UTC 2011
CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.
Proceedings of the National Academy of Sciences of the United States of America
Zhao XW,van Beek EM,Schornagel K,Van der Maaden H,Van Houdt M,Otten MA,Finetti P,Van Egmond M,Matozaki T,Kraal G,Birnbaum D,van Elsas A,Kuijpers TW,Bertucci F,van den Berg TK
Tue Nov 08 00:00:00 UTC 2011
A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.
PLoS pathogens
Beham AW,Puellmann K,Laird R,Fuchs T,Streich R,Breysach C,Raddatz D,Oniga S,Peccerella T,Findeisen P,Kzhyshkowska J,Gratchev A,Schweyer S,Saunders B,Wessels JT,Möbius W,Keane J,Becker H,Ganser A,Neumaier M,Kaminski WE
Tue Nov 01 00:00:00 UTC 2011
Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Harui A,Kiertscher SM,Roth MD
Tue Mar 01 00:00:00 UTC 2011
Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.
European journal of immunology
Tomlinson GS,Cashmore TJ,Elkington PT,Yates J,Lehloenya RJ,Tsang J,Brown M,Miller RF,Dheda K,Katz DR,Chain BM,Noursadeghi M
Tue Nov 01 00:00:00 UTC 2011
Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.
Journal of immunology (Baltimore, Md. : 1950)
Mittag D,Proietto AI,Loudovaris T,Mannering SI,Vremec D,Shortman K,Wu L,Harrison LC
Wed Jun 01 00:00:00 UTC 2011
Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950)
Rizvi SM,Del Cid N,Lybarger L,Raghavan M
Tue Feb 15 00:00:00 UTC 2011
Cohesin regulates MHC class II genes through interactions with MHC class II insulators.
Journal of immunology (Baltimore, Md. : 1950)
Majumder P,Boss JM
Sat Oct 15 00:00:00 UTC 2011
Glycogen synthase kinase-3 facilitates con a-induced IFN-γ-- mediated immune hepatic injury.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CC,Huang WC,Chen CL,Hsieh CY,Lin YS,Chen SH,Yang KC,Lin CF
Sat Oct 01 00:00:00 UTC 2011
Two unique human decidual macrophage populations.
Journal of immunology (Baltimore, Md. : 1950)
Houser BL,Tilburgs T,Hill J,Nicotra ML,Strominger JL
Tue Feb 15 00:00:00 UTC 2011
Cytotoxic dendritic cells generated from cancer patients.
Journal of immunology (Baltimore, Md. : 1950)
Lakomy D,Janikashvili N,Fraszczak J,Trad M,Audia S,Samson M,Ciudad M,Vinit J,Vergely C,Caillot D,Foucher P,Lagrost L,Chouaib S,Katsanis E,Larmonier N,Bonnotte B
Thu Sep 01 00:00:00 UTC 2011
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J
Sat Oct 01 00:00:00 UTC 2011
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Journal of immunology (Baltimore, Md. : 1950)
Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH
Fri Apr 01 00:00:00 UTC 2011
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Ansari NA,Kumar R,Gautam S,Nylén S,Singh OP,Sundar S,Sacks D
Fri Apr 01 00:00:00 UTC 2011
Protection from RNA and DNA viruses by IL-32.
Journal of immunology (Baltimore, Md. : 1950)
Zepp JA,Nold-Petry CA,Dinarello CA,Nold MF
Fri Apr 01 00:00:00 UTC 2011
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Chevalier N,Jarrossay D,Ho E,Avery DT,Ma CS,Yu D,Sallusto F,Tangye SG,Mackay CR
Sun May 15 00:00:00 UTC 2011
A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Qi HY,Daniels MP,Liu Y,Chen LY,Alsaaty S,Levine SJ,Shelhamer JH
Tue Nov 15 00:00:00 UTC 2011
Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.
Experimental cell research
Burton VJ,Butler LM,McGettrick HM,Stone PC,Jeffery HC,Savage CO,Rainger GE,Nash GB
Tue Feb 01 00:00:00 UTC 2011
Growth of human colorectal cancer SW1116 cells is inhibited by cytokine-induced killer cells.
Clinical & developmental immunology
Wang Y,Dai H,Li H,Lv H,Wang T,Fu X,Han W
Tue Aug 02 00:00:00 UTC 2011
Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.
Journal of inflammation (London, England)
Asp L,Johansson AS,Mann A,Owe-Larsson B,Urbanska EM,Kocki T,Kegel M,Engberg G,Lundkvist GB,Karlsson H
Sat Oct 08 00:00:00 UTC 2011
The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide.
Clinical & developmental immunology
Tan G,Zhang X,Feng H,Luo H,Wang Z
Wed Jun 06 00:00:00 UTC 2012
Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms.
BMC physiology
Lillvis JH,Erdman R,Schworer CM,Golden A,Derr K,Gatalica Z,Cox LA,Shen J,Vander Heide RS,Lenk GM,Hlavaty L,Li L,Elmore JR,Franklin DP,Gray JL,Garvin RP,Carey DJ,Lancaster WD,Tromp G,Kuivaniemi H
Tue May 31 00:00:00 UTC 2011
Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate.
Journal of translational medicine
Chiang CL,Maier DA,Kandalaft LE,Brennan AL,Lanitis E,Ye Q,Levine BL,Czerniecki BJ,Powell DJ,Coukos G
Mon Nov 14 00:00:00 UTC 2011
A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response.
Journal of translational medicine
Chakera A,Bennett SC,Cornall RJ
Fri Aug 26 00:00:00 UTC 2011
Binding of albumin promotes bacterial survival at the epithelial surface.
The Journal of biological chemistry
Egesten A,Frick IM,Mörgelin M,Olin AI,Björck L
Fri Jan 28 00:00:00 UTC 2011
Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro.
PloS one
Mokhtari D,Li T,Lu T,Welsh N
Tue Feb 28 00:00:00 UTC 2012
Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis.
The Journal of biological chemistry
Shiou SR,Yu Y,Chen S,Ciancio MJ,Petrof EO,Sun J,Claud EC
Fri Apr 08 00:00:00 UTC 2011
Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms.
Infectious diseases in obstetrics and gynecology
Ibana JA,Schust DJ,Sugimoto J,Nagamatsu T,Greene SJ,Quayle AJ
Fri Oct 28 00:00:00 UTC 2011
Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.
PloS one
Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G
Mon Aug 27 00:00:00 UTC 2012
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway.
Journal of neuroinflammation
Tarassishin L,Suh HS,Lee SC
Fri Dec 30 00:00:00 UTC 2011
Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption.
PloS one
Chang CP,Yang MC,Lei HY
Fri Jul 20 00:00:00 UTC 2012
Detection and monitoring of the multiple inflammatory responses by photoacoustic molecular imaging using selectively targeted gold nanorods.
Biomedical optics express
Ha S,Carson A,Agarwal A,Kotov NA,Kim K
Wed Feb 23 00:00:00 UTC 2011
Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis.
The Journal of biological chemistry
Kamata Y,Yamamoto M,Kawakami F,Tsuboi R,Takeda A,Ishihara K,Hibino T
Fri Mar 11 00:00:00 UTC 2011
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
The Journal of biological chemistry
Lobito AA,Ramani SR,Tom I,Bazan JF,Luis E,Fairbrother WJ,Ouyang W,Gonzalez LC
Fri May 27 00:00:00 UTC 2011
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.
BMC complementary and alternative medicine
Schwager J,Hoeller U,Wolfram S,Richard N
Thu Nov 03 00:00:00 UTC 2011
Deactivation of STAT6 through serine 707 phosphorylation by JNK.
The Journal of biological chemistry
Shirakawa T,Kawazoe Y,Tsujikawa T,Jung D,Sato S,Uesugi M
Fri Feb 04 00:00:00 UTC 2011
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 UTC 2010
Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery.
Blood
Robson NC,McAlpine T,Knights AJ,Schnurr M,Shin A,Chen W,Maraskovsky E,Cebon J
Thu Jul 15 00:00:00 UTC 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 UTC 2010
Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
Blood
Vujanovic L,Szymkowski DE,Alber S,Watkins SC,Vujanovic NL,Butterfield LH
Thu Jul 29 00:00:00 UTC 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
Thu Oct 07 00:00:00 UTC 2010
Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity.
Blood
Lemoine R,Velge-Roussel F,Herr F,Felix R,Nivet H,Lebranchu Y,Baron C
Thu Oct 21 00:00:00 UTC 2010
Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection.
Blood
Muntasell A,Magri G,Pende D,Angulo A,López-Botet M
Thu Jun 24 00:00:00 UTC 2010
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
The Journal of experimental medicine
Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H
Mon Nov 22 00:00:00 UTC 2010
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.
Proceedings of the National Academy of Sciences of the United States of America
Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E
Tue Jan 12 00:00:00 UTC 2010
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.
Journal of biomedical science
Gutwein P,Schramme A,Abdel-Bakky MS,Doberstein K,Hauser IA,Ludwig A,Altevogt P,Gauer S,Hillmann A,Weide T,Jespersen C,Eberhardt W,Pfeilschifter J
Wed Jan 13 00:00:00 UTC 2010
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.
Journal of clinical immunology
Heidemann SC,Chavez V,Landers CJ,Kucharzik T,Prehn JL,Targan SR
Thu Jul 01 00:00:00 UTC 2010
Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium.
Immunology
McGettrick HM,Buckley CD,Filer A,Rainger GE,Nash GB
Mon Nov 01 00:00:00 UTC 2010
In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors.
Cancer immunology, immunotherapy : CII
Berthon C,Driss V,Liu J,Kuranda K,Leleu X,Jouy N,Hetuin D,Quesnel B
Wed Dec 01 00:00:00 UTC 2010
Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
Esmann L,Idel C,Sarkar A,Hellberg L,Behnen M,Möller S,van Zandbergen G,Klinger M,Köhl J,Bussmeyer U,Solbach W,Laskay T
Fri Jan 01 00:00:00 UTC 2010
Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.
Journal of immunology (Baltimore, Md. : 1950)
Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J
Wed Dec 01 00:00:00 UTC 2010
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Journal of immunology (Baltimore, Md. : 1950)
Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH
Mon Mar 15 00:00:00 UTC 2010
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.
Journal of immunology (Baltimore, Md. : 1950)
McLaren JE,Calder CJ,McSharry BP,Sexton K,Salter RC,Singh NN,Wilkinson GW,Wang EC,Ramji DP
Sat May 15 00:00:00 UTC 2010
ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Li N,McLaren JE,Michael DR,Clement M,Fielding CA,Ramji DP
Wed Sep 01 00:00:00 UTC 2010
The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
Journal of immunology (Baltimore, Md. : 1950)
James DE,Nestor BJ,Sculco TP,Ivashkiv LB,Ross FP,Goldring SR,Purdue PE
Thu Jul 15 00:00:00 UTC 2010
Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Matsuzaki S,Ishizuka T,Hisada T,Aoki H,Komachi M,Ichimonji I,Utsugi M,Ono A,Koga Y,Dobashi K,Kurose H,Tomura H,Mori M,Okajima F
Fri Oct 15 00:00:00 UTC 2010
Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility.
Journal of immunology (Baltimore, Md. : 1950)
Solinas G,Schiarea S,Liguori M,Fabbri M,Pesce S,Zammataro L,Pasqualini F,Nebuloni M,Chiabrando C,Mantovani A,Allavena P
Thu Jul 01 00:00:00 UTC 2010
IL-17 immunity in human type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Honkanen J,Nieminen JK,Gao R,Luopajarvi K,Salo HM,Ilonen J,Knip M,Otonkoski T,Vaarala O
Sun Aug 01 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.
Epigenetics & chromatin
Koues OI,Mehta NT,Truax AD,Dudley RK,Brooks JK,Greer SF
Thu Feb 04 00:00:00 UTC 2010
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells.
The Journal of biological chemistry
Pruessmeyer J,Martin C,Hess FM,Schwarz N,Schmidt S,Kogel T,Hoettecke N,Schmidt B,Sechi A,Uhlig S,Ludwig A
Fri Jan 01 00:00:00 UTC 2010
Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages.
BMC immunology
Joshi AD,Oak SR,Hartigan AJ,Finn WG,Kunkel SL,Duffy KE,Das A,Hogaboam CM
Tue Oct 19 00:00:00 UTC 2010
Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.
The Journal of biological chemistry
Chang YP,Tsai CC,Huang WC,Wang CY,Chen CL,Lin YS,Kai JI,Hsieh CY,Cheng YL,Choi PC,Chen SH,Chang SP,Liu HS,Lin CF
Fri Sep 10 00:00:00 UTC 2010
Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis.
PloS one
Nold-Petry CA,Lehrnbecher T,Jarisch A,Schwabe D,Pfeilschifter JM,Muhl H,Nold MF
Wed Jan 13 00:00:00 UTC 2010
SH2 modified STAT1 induces HLA-I expression and improves IFN-γ signaling in IFN-α resistant HCV replicon cells.
PloS one
Poat B,Hazari S,Chandra PK,Gunduz F,Balart LA,Alvarez X,Dash S
Thu Sep 30 00:00:00 UTC 2010
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.
PloS one
Van Grol J,Subauste C,Andrade RM,Fujinaga K,Nelson J,Subauste CS
Thu Jul 22 00:00:00 UTC 2010
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
PloS one
Fred RG,Bang-Berthelsen CH,Mandrup-Poulsen T,Grunnet LG,Welsh N
Wed May 26 00:00:00 UTC 2010
Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.
PloS one
Edwards LA,Nistala K,Mills DC,Stephenson HN,Zilbauer M,Wren BW,Dorrell N,Lindley KJ,Wedderburn LR,Bajaj-Elliott M
Tue Nov 09 00:00:00 UTC 2010
Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.
Journal of inflammation (London, England)
Jensen SS,Gad M
Tue Jul 27 00:00:00 UTC 2010
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.
Nature communications
Aichem A,Pelzer C,Lukasiak S,Kalveram B,Sheppard PW,Rani N,Schmidtke G,Groettrup M
Tue May 04 00:00:00 UTC 2010
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Blood
Caruso R,Stolfi C,Sarra M,Rizzo A,Fantini MC,Pallone F,MacDonald TT,Monteleone G
Thu Apr 09 00:00:00 UTC 2009
C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function.
Blood
Bossi F,Rizzi L,Bulla R,Debeus A,Tripodo C,Picotti P,Betto E,Macor P,Pucillo C,Würzner R,Tedesco F
Thu Apr 09 00:00:00 UTC 2009
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
Blood
Van den Bossche J,Bogaert P,van Hengel J,Guérin CJ,Berx G,Movahedi K,Van den Bergh R,Pereira-Fernandes A,Geuns JM,Pircher H,Dorny P,Grooten J,De Baetselier P,Van Ginderachter JA
Thu Nov 19 00:00:00 UTC 2009
Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa.
Blood
Dai X,Jayapal M,Tay HK,Reghunathan R,Lin G,Too CT,Lim YT,Chan SH,Kemeny DM,Floto RA,Smith KG,Melendez AJ,MacAry PA
Thu Jul 09 00:00:00 UTC 2009
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.
Blood
Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC
Thu Feb 12 00:00:00 UTC 2009
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Blood
Koenen RR,Pruessmeyer J,Soehnlein O,Fraemohs L,Zernecke A,Schwarz N,Reiss K,Sarabi A,Lindbom L,Hackeng TM,Weber C,Ludwig A
Thu May 07 00:00:00 UTC 2009
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.
The Journal of experimental medicine
Minegishi Y,Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Karasuyama H
Mon Jun 08 00:00:00 UTC 2009
Characterization and regulation of bv8 in human blood cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhong C,Qu X,Tan M,Meng YG,Ferrara N
Wed Apr 15 00:00:00 UTC 2009
Melan-A-specific cytotoxic T cells are associated with tumor regression and autoimmunity following treatment with anti-CTLA-4.
Clinical cancer research : an official journal of the American Association for Cancer Research
Klein O,Ebert LM,Nicholaou T,Browning J,Russell SE,Zuber M,Jackson HM,Dimopoulos N,Tan BS,Hoos A,Luescher IF,Davis ID,Chen W,Cebon J
Wed Apr 01 00:00:00 UTC 2009
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.
Proceedings of the National Academy of Sciences of the United States of America
Porta C,Rimoldi M,Raes G,Brys L,Ghezzi P,Di Liberto D,Dieli F,Ghisletti S,Natoli G,De Baetselier P,Mantovani A,Sica A
Tue Sep 01 00:00:00 UTC 2009
Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.
Clinical immunology (Orlando, Fla.)
Okumura S,Yuki K,Kobayashi R,Okamura S,Ohmori K,Saito H,Ra C,Okayama Y
Sun Feb 01 00:00:00 UTC 2009
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.
PLoS pathogens
Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B
Sun Feb 01 00:00:00 UTC 2009
Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration.
Journal of leukocyte biology
McGettrick HM,Hunter K,Moss PA,Buckley CD,Rainger GE,Nash GB
Thu Jan 01 00:00:00 UTC 2009
Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype.
The American journal of pathology
Boyle JJ,Harrington HA,Piper E,Elderfield K,Stark J,Landis RC,Haskard DO
Sun Mar 01 00:00:00 UTC 2009
HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Tabayoyong WB,Salas JG,Bonde S,Zavazava N
Sun Nov 01 00:00:00 UTC 2009
HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Tabayoyong WB,Salas JG,Bonde S,Zavazava N
Sun Nov 01 00:00:00 UTC 2009
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins.
Journal of immunology (Baltimore, Md. : 1950)
Miles K,Clarke DJ,Lu W,Sibinska Z,Beaumont PE,Davidson DJ,Barr TA,Campopiano DJ,Gray M
Sat Aug 01 00:00:00 UTC 2009
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kurowska-Stolarska M,Stolarski B,Kewin P,Murphy G,Corrigan CJ,Ying S,Pitman N,Mirchandani A,Rana B,van Rooijen N,Shepherd M,McSharry C,McInnes IB,Xu D,Liew FY
Sun Nov 15 00:00:00 UTC 2009
IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Sundstrom JB,Hair GA,Ansari AA,Secor WE,Gilfillan AM,Metcalfe DD,Kirshenbaum AS
Fri May 15 00:00:00 UTC 2009
Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway.
Journal of immunology (Baltimore, Md. : 1950)
Noursadeghi M,Tsang J,Miller RF,Straschewski S,Kellam P,Chain BM,Katz DR
Thu Jan 01 00:00:00 UTC 2009
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses.
Journal of immunology (Baltimore, Md. : 1950)
Haan C,Kroy DC,Wüller S,Sommer U,Nöcker T,Rolvering C,Behrmann I,Heinrich PC,Haan S
Sun Mar 01 00:00:00 UTC 2009
Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CC,Kai JI,Huang WC,Wang CY,Wang Y,Chen CL,Fang YT,Lin YS,Anderson R,Chen SH,Tsao CW,Lin CF
Wed Jul 15 00:00:00 UTC 2009
Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Q,Shi S,Liu Y,Uyanne J,Shi Y,Shi S,Le AD
Tue Dec 15 00:00:00 UTC 2009
A novel antiangiogenic effect for telomerase-specific virotherapy through host immune system.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda Y,Kojima T,Kuroda S,Endo Y,Sakai R,Hioki M,Kishimoto H,Uno F,Kagawa S,Watanabe Y,Hashimoto Y,Urata Y,Tanaka N,Fujiwara T
Sun Feb 01 00:00:00 UTC 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 UTC 2009
Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential.
Tissue engineering. Part A
Lombardo E,DelaRosa O,Mancheño-Corvo P,Menta R,Ramírez C,Büscher D
Wed Jul 01 00:00:00 UTC 2009
Inhibition of hepatitis C virus infection by interferon-gamma through downregulating claudin-1.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Wei X,Jia ZS,Lian JQ,Zhang Y,Li J,Ma L,Ye L,Wang JP,Pan L,Wang PZ,Bai XF
Sun Mar 01 00:00:00 UTC 2009
A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury.
PloS one
Santamaría B,Benito-Martin A,Ucero AC,Aroeira LS,Reyero A,Vicent MJ,Orzáez M,Celdrán A,Esteban J,Selgas R,Ruíz-Ortega M,Cabrera ML,Egido J,Pérez-Payá E,Ortiz A
Thu Aug 13 00:00:00 UTC 2009
Human TRIM gene expression in response to interferons.
PloS one
Carthagena L,Bergamaschi A,Luna JM,David A,Uchil PD,Margottin-Goguet F,Mothes W,Hazan U,Transy C,Pancino G,Nisole S
Thu May 28 00:00:00 UTC 2009
Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.
PloS one
Pilling D,Fan T,Huang D,Kaul B,Gomer RH
Fri Oct 16 00:00:00 UTC 2009
Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.
The Journal of biological chemistry
Song W,Liu G,Bosworth CA,Walker JR,Megaw GA,Lazrak A,Abraham E,Sullender WM,Matalon S
Fri Mar 13 00:00:00 UTC 2009
SufA of the opportunistic pathogen finegoldia magna modulates actions of the antibacterial chemokine MIG/CXCL9, promoting bacterial survival during epithelial inflammation.
The Journal of biological chemistry
Karlsson C,Eliasson M,Olin AI,Mörgelin M,Karlsson A,Malmsten M,Egesten A,Frick IM
Fri Oct 23 00:00:00 UTC 2009
Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis.
Blood
Stefanescu R,Bassett D,Modarresi R,Santiago F,Fakruddin M,Laurence J
Tue Jul 15 00:00:00 UTC 2008
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.
Blood
Loos T,Mortier A,Gouwy M,Ronsse I,Put W,Lenaerts JP,Van Damme J,Proost P
Wed Oct 01 00:00:00 UTC 2008
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.
Clinical immunology (Orlando, Fla.)
Bradshaw EM,Kent SC,Tripuraneni V,Orban T,Ploegh HL,Hafler DA,Love JC
Wed Oct 01 00:00:00 UTC 2008
Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells.
Stem cells (Dayton, Ohio)
Johansson S,Price J,Modo M
Mon Sep 01 00:00:00 UTC 2008
Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus.
Arthritis research & therapy
Monrad SU,Rea K,Thacker S,Kaplan MJ
Fri Feb 20 00:00:00 UTC 2009
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Journal of immunology (Baltimore, Md. : 1950)
Hartl D,Krauss-Etschmann S,Koller B,Hordijk PL,Kuijpers TW,Hoffmann F,Hector A,Eber E,Marcos V,Bittmann I,Eickelberg O,Griese M,Roos D
Mon Dec 01 00:00:00 UTC 2008
IFN-gamma impairs release of IL-8 by IL-1beta-stimulated A549 lung carcinoma cells.
BMC cancer
Boost KA,Sadik CD,Bachmann M,Zwissler B,Pfeilschifter J,Mühl H
Thu Sep 18 00:00:00 UTC 2008
CXCL10 promotes invasion-related properties in human colorectal carcinoma cells.
Cancer research
Zipin-Roitman A,Meshel T,Sagi-Assif O,Shalmon B,Avivi C,Pfeffer RM,Witz IP,Ben-Baruch A
Sun Apr 01 00:00:00 UTC 2007
Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus.
Proceedings of the National Academy of Sciences of the United States of America
Huang J,Smirnov SV,Lewis-Antes A,Balan M,Li W,Tang S,Silke GV,Pütz MM,Smith GL,Kotenko SV
Tue Jun 05 00:00:00 UTC 2007
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.
The Journal of biological chemistry
Ziesché E,Bachmann M,Kleinert H,Pfeilschifter J,Mühl H
Fri Jun 01 00:00:00 UTC 2007
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 UTC 2006
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
Journal of immunology (Baltimore, Md. : 1950)
Eksteen B,Miles A,Curbishley SM,Tselepis C,Grant AJ,Walker LS,Adams DH
Sat Jul 01 00:00:00 UTC 2006
Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L.
Blood
Kemp TJ,Ludwig AT,Earel JK,Moore JM,Vanoosten RL,Moses B,Leidal K,Nauseef WM,Griffith TS
Tue Nov 15 00:00:00 UTC 2005
Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response.
Journal of immunology (Baltimore, Md. : 1950)
Ohtani T,Nakagawa S,Kurosawa M,Mizuashi M,Ozawa M,Aiba S
Tue Feb 15 00:00:00 UTC 2005
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.
The European respiratory journal
Pilette C,Francis JN,Till SJ,Durham SR
Tue Jun 01 00:00:00 UTC 2004
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.
The European respiratory journal
Pilette C,Francis JN,Till SJ,Durham SR
Tue Jun 01 00:00:00 UTC 2004
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
Cancer research
Azenshtein E,Luboshits G,Shina S,Neumark E,Shahbazian D,Weil M,Wigler N,Keydar I,Ben-Baruch A
Fri Feb 15 00:00:00 UTC 2002
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Maertzdorf J,Osterhaus AD,Verjans GM
Fri Nov 15 00:00:00 UTC 2002
Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119.
Immunology
Garraud O,Diouf A,Holm I,Perraut R,Longacre S
Thu Jul 01 00:00:00 UTC 1999
