Product References
Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth.
iScience
Xie X,Gou F,Zheng Z,Zhang Y,Zhang Y,Dong F,Cheng T,Cheng H
200-02 was used in Cell Culture to elucidate the dynamics of fetal hematopoiesis in preparation for birth, offering valuable insights into the pathological processes underlying leukemia.
Fri Aug 16 00:00:00 UTC 2024
Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Cell reports. Medicine
Albanese M,Chen HR,Gapp M,Muenchhoff M,Yang HH,Peterhoff D,Hoffmann K,Xiao Q,Ruhle A,Ambiel I,Schneider S,Mejías-Pérez E,Stern M,Wratil PR,Hofmann K,Amann L,Jocham L,Fuchs T,Ulivi AF,Besson-Girard S,Weidlich S,Schneider J,Spinner CD,Sutter K,Dittmer U,Humpe A,Baumeister P,Wieser A,Rothenfusser S,Bogner J,Roider J,Knolle P,Hengel H,Wagner R,Laketa V,Fackler OT,Keppler OT
200-02 was used in Cell activation to report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer.
Tue Apr 16 00:00:00 UTC 2024
Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response.
Nature communications
Tan L,Yin T,Xiang H,Wang L,Mudgal P,Chen J,Ding Y,Wang G,Lim BJW,Huang Y,Huang D,Liang Y,Alexander PB,Xiang K,Wang E,Yan C,Ma Z,Tan M,Li QJ,Wang XF
200-02 was used in Cell Culture to show that the epigenetic regulator ubiquitin-like with PHD and ring finger domains 1 (UHRF1), exhibits altered expression and aberrant cytosolic localization in cancerous tissues, where it promotes MHC-I ubiquitination and degradation.
Thu Oct 03 00:00:00 UTC 2024
Imaging CAR-T Synapse as a Quality Control for CAR Engineering.
Methods in molecular biology (Clifton, N.J.)
Xiao Q,Su X
200-02 was used in In vitro experiments to describe two methods as a quality control for validating newly developed CARs: (1) the cell-cell conjugation assay as a reflection of efficient binding of CAR to antigen in the cellular context and (2) CD45 exclusion in the synapse as an indication of CAR signaling potential.
Mon May 01 00:00:00 UTC 2023
FTO negatively regulates the cytotoxic activity of natural killer cells.
EMBO reports
Kim SM,Oh SC,Lee SY,Kong LZ,Lee JH,Kim TD
200-02 was used in Cell Culture to suggest that FTO is an essential modulator of NK cell immunity, providing a new immunotherapeutic strategy for allogeneic NK cell therapies.
Wed Apr 05 00:00:00 UTC 2023
HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma.
Neuro-oncology advances
Wang SS,Davenport AJ,Iliopoulos M,Hughes-Parry HE,Watson KA,Arcucci V,Mulazzani M,Eisenstat DD,Hansford JR,Cross RS,Jenkins MR
200-02 was used in Cell Culture to provide strong preclinical evidence for the inclusion of Diffuse intrinsic pontine glioma patients in future paediatric CNS tumour HER2 Chimeric antigen receptor T cell clinical trials.
Tue May 09 00:00:00 UTC 2023
An evolved AAV variant enables efficient genetic engineering of murine T cells.
Cell
Nyberg WA,Ark J,To A,Clouden S,Reeder G,Muldoon JJ,Chung JY,Xie WH,Allain V,Steinhart Z,Chang C,Talbot A,Kim S,Rosales A,Havlik LP,Pimentel H,Asokan A,Eyquem J
200-02 was used in Cell Culture to demonstrate that Ark313 can be used for nucleofection-free DNA delivery, CRISPR-Cas9-mediated knockouts, and targeted integration of large transgenes.
Thu Jan 19 00:00:00 UTC 2023
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells.
Nature communications
Santos MF,Rappa G,Karbanová J,Diana P,Cirrincione G,Carbone D,Manna D,Aalam F,Wang D,Vanier C,Corbeil D,Lorico A
200-02 was used in Cell Culture to report that in HeLa cells and activated CD4+ T cells infected with HIV-1 pseudotyped with VSV-G and native Env protein, respectively, Rab7+ late endosomes containing endocytosed HIV-1 promote the formation of nuclear envelope invaginations (NEIs).
Thu Aug 10 00:00:00 UTC 2023
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design.
iScience
Li YR,Ochoa CJ,Zhu Y,Kramer A,Wilson M,Fang Y,Chen Y,Singh T,Di Bernardo G,Zhu E,Lee D,Moatamed NA,Bando J,Zhou JJ,Memarzadeh S,Yang L
200-02 was used in In vitro experiments to we conducted a comprehensive analysis of primary tumor cells and their microenvironment from 16 chemonaive and 10 recurrent ovarian cancer (OC) patient samples.
Fri Oct 20 00:00:00 UTC 2023
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.
Science advances
Hildenbrand K,Bohnacker S,Menon PR,Kerle A,Prodjinotho UF,Hartung F,Strasser PC,Catici DAM,Rührnößl F,Haslbeck M,Schumann K,Müller SI,da Costa CP,Esser-von Bieren J,Feige MJ
200-02 was used in Cell Culture to reveal IL-12α and EBI3, the subunits of IL-35, to be functionally active anti-inflammatory immune molecules on their own.
Fri Oct 27 00:00:00 UTC 2023
How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays.
Biomedicines
Pascucci GR,Morrocchi E,Pighi C,Rotili A,Neri A,Medri C,Olivieri G,Sanna M,Rasi G,Persaud D,Chahroudi A,Lichterfeld M,Nastouli E,Cancrini C,Amodio D,Rossi P,Cotugno N,Palma P
200-02 was used in In vitro experiments to suggest that for studies aiming at quantifying the magnitude of biological mechanisms under T cell activation, the autologous plasma could better approximate the in vivo environment.
Mon Mar 13 00:00:00 UTC 2023
Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes.
EBioMedicine
Wu F,Yin YY,Fan WH,Zhai Y,Yu MC,Wang D,Pan CQ,Zhao Z,Li GZ,Zhang W
200-02 was used in Cell Culture to provide further insights into patient stratification as well as presents opportunities for therapeutic development in human oligodendrogliomas.
Sun Jan 01 00:00:00 UTC 2023
IL-33 promotes double negative T cell survival via the NF-κB pathway.
Cell death & disease
Sun X,Zhang C,Sun F,Li S,Wang Y,Wang T,Li L
200-02 was used in In vitro experiments to demonstrated that the IL-33 receptor ST2 was expressed on double negative T (DNT) cells, and that IL-33 stimulation increased DNT cells proliferation and survival in vivo and in vitro.
Wed Apr 05 00:00:00 UTC 2023
Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling.
Nature communications
Nunes-Santos CJ,Kuehn H,Boast B,Hwang S,Kuhns DB,Stoddard J,Niemela JE,Fink DL,Pittaluga S,Abu-Asab M,Davies JS,Barr VA,Kawai T,Delmonte OM,Bosticardo M,Garofalo M,Carneiro-Sampaio M,Somech R,Gharagozlou M,Parvaneh N,Samelson LE,Fleisher TA,Puel A,Notarangelo LD,Boisson B,Casanova JL,Derfalvi B,Rosenzweig SD
200-02 was used in In vitro experiments to show that interleukin (IL)-6 signaling is distinctively impacted in this syndrome.
Thu Jun 22 00:00:00 UTC 2023
A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.
Advanced biology
Meng Z,Niu X,Xia L,Chen Y,Wang Z,Wang H,Ji P,Cui W,Wang Y,Lu S
200-02 was used in Cell Culture to establish that the 3D-HyGTIC system is not only inclined to mimic the early differentiation trajectories of tumor-infiltrating CD8+ T cells but also may facilitate an evaluation of the efficacy of IC blockades and guide the designing of combination immunotherapy.
Sat Jul 01 00:00:00 UTC 2023
Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model.
Cancer cell international
Kim HA,Kim H,Nam MK,Park JK,Lee MY,Chung S,Lee KM,Kuh HJ
200-02 was used in Cell Culture to invesitgate the effect of activated pancreatic stellate cells (aPSCs) on NK cell-mediated anticancer efficacy under three-dimensional (3D) coculture conditions.
Wed Sep 27 00:00:00 UTC 2023
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
Cancer immunology research
Lao L,Zeng W,Huang P,Chen H,Jia Z,Wang P,Huang D,Chen J,Nie Y,Yang L,Wu W,Liu J
200-02 was used in Cell Culture to identify a subset of CD161-overexpressing CD8+ T cells enriched in chemoresistant tumors. CD161 engagement repressed the calcium influx and cytolytic capacity of CD8+ T cells through acid sphingomyelinase activation and ceramide generation.
Wed Mar 01 00:00:00 UTC 2023
Tumor Cell-Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β-Oxidation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li J,Xia Q,Di C,Li C,Si H,Zhou B,Yu S,Li Y,Huang J,Lu Y,Huang M,Liang H,Liu X,Zhao Q
200-02 was used in Cell Culture to show that CD96 is frequently expressed in tumor cells from clinical breast cancer samples and is correlated with poor long-term prognosis in these patients.
Wed Mar 01 00:00:00 UTC 2023
SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters.
Cancers
Groß E,Hilger RA,Schümann FL,Bauer M,Bouska A,Rohde C,Willscher E,Lützkendorf J,Müller LP,Edemir B,Mueller T,Herling M,Binder M,Wickenhauser C,Iqbal J,Posern G,Weber T
200-02 was used in Cell Culture to investigate enhancer of zeste homologue 2 expression in two cohorts of T-cell lymphomas by mRNA-profiling and immunohistochemistry, both revealing overexpression to have a negative impact on patients' prognosis.
Sat Jun 03 00:00:00 UTC 2023
Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.
Scientific reports
Deering RP,Blumenberg L,Li L,Dhanik A,Jeong S,Pourpe S,Song H,Boucher L,Ragunathan S,Li Y,Zhong M,Kuhnert J,Adler C,Hawkins P,Gupta NT,Moore M,Ni M,Hansen J,Wei Y,Thurston G
200-02 was used in Cell Culture to demonstrate that RAPTER identified specific reactivities to viral and tumor antigens at sensitivities as low as 0.15% of total CD8+ T cells, and deconvoluted low-frequency circulating HPV16-specific T cell clones from a cervical cancer patient.
Thu May 25 00:00:00 UTC 2023
Bach2 in CD4+ T cells from SLE patients modulates B-cell differentiation and IgG production.
European journal of immunology
Long D,Yang B,Yang M,Xiong F,Zhu X,Tan Y,Wu H
200-02 was used in Flow cytometry/Cell sorting to assess Bach2 levels, bisulfite sequencing PCR was used to measure the methylation level, and silencing by electroporation and stimulation with a cytokine concentration gradient were used to investigate the effect of Bach2 on T cells.
Sat Apr 01 00:00:00 UTC 2023
Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.
iScience
Hilliard S,Mosoyan K,Branciamore S,Gogoshin G,Zhang A,Simons DL,Rockne RC,Lee PP,Rodin AS
200-02 was used in In vitro experiments to propose that the ubiquitous information-theoretic principles underlying the development of artificial neural networks are similar to the principles guiding the macro-evolution of biological networks and that insights gained from one field can be applied to the other.
Fri Feb 17 00:00:00 UTC 2023
SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.
Signal transduction and targeted therapy
Yi X,Wang H,Yang Y,Wang H,Zhang H,Guo S,Chen J,Du J,Tian Y,Ma J,Zhang B,Wu L,Shi Q,Gao T,Guo W,Li C
200-02 was used in Cell Culture to report that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.
Wed Mar 15 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
200-02 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
Soluble programmed death ligand-1-induced immunosuppressive effects on chimeric antigen receptor-natural killer cells targeting Glypican-3 in hepatocellular carcinoma.
Immunology
Chen L,Liu S,Adah D,Sun Q,Liang Z,Ho M,Sun B
200-02 was used in In vitro experiments to demonstrate that L3C7c-Fc could enhance the therapeutic effect of CAR-NK cells by reversing the suppression of sPD-L1, which provides the experimental evidence for the subsequent development of HCC immunotherapy strategies.
Thu Jun 01 00:00:00 UTC 2023
Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells.
JCI insight
Elmarsafawi AG,Hesterberg RS,Fernandez MR,Yang C,Darville LN,Liu M,Koomen JM,Phanstiel O,Atkins R,Mullinax JE,Pilon-Thomas SA,Locke FL,Epling-Burnette PK,Cleveland JL
200-02 was used in In vitro experiments to demonstrate that the glutamine/polyamine/hypusine axis controlled the expression of CD69, an important regulator of tissue-resident memory T cells.
Fri Sep 22 00:00:00 UTC 2023
Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines.
Biomacromolecules
Birnbaum LA,Sullivan EC,Do P,Uricoli B,Raikar SS,Porter CC,Henry CJ,Dreaden EC
200-02 was used in In vitro experiments to demonstrate a novel approach to control extracellular immune cell signals using light, a strategy that in the future may improve our understanding of and ability to treat cancer and other diseases.
Mon Mar 13 00:00:00 UTC 2023
NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy.
Biomaterials research
Kim D,Jo S,Lee D,Kim SM,Seok JM,Yeo SJ,Lee JH,Lee JJ,Lee K,Kim TD,Park SA
200-02 was used in Cell Culture to demonstrate that the hydrogel encapsulating Natural killer cells created an appropriate micro-macro environment for clinical applications of NK cell therapy for both leukaemia and solid tumours via 3D bioprinting.
Thu Jun 22 00:00:00 UTC 2023
EGFR as a potent CAR T target in triple negative breast cancer brain metastases.
Breast cancer research and treatment
Subham S,Jeppson JD,Worcester C,Schatmeyer B,Zhao J,Madan R,Lakis NS,Kimler BF,McGuirk JP,Chen RC,Stecklein SR,Akhavan D
200-02 was used in Cell Culture to demonstrate anti-tumor activity of EGFR806 CAR T cells against TNBC cells in vitro and in vivo.
Sun Jan 01 00:00:00 UTC 2023
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity.
Cellular and molecular gastroenterology and hepatology
Rivera KR,Bliton RJ,Burclaff J,Czerwinski MJ,Liu J,Trueblood JM,Hinesley CM,Breau KA,Deal HE,Joshi S,Pozdin VA,Yao M,Ziegler AL,Blikslager AT,Daniele MA,Magness ST
200-02 was used in In vitro experiments to present a new microphysiological system (MPS) to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolonged hypoxia modulates how hISCs respond to inflammation-associated interleukins (ILs).
Mon Oct 23 00:00:00 UTC 2023
WT1 Pulsed Human CD141+ Dendritic Cell Vaccine Has High Potential in Solid Tumor-Targeted Immunotherapy.
International journal of molecular sciences
Cho SY,Jeong SM,Jeon YJ,Yang SJ,Hwang JE,Yoo BM,Kim HS
200-02 was used in Cell Culture to develop a DC vaccine named CellgramDC-WT1 (CDW).
Thu Jan 12 00:00:00 UTC 2023
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma.
Journal of experimental & clinical cancer research : CR
Cui Y,Li J,Zhang P,Yin D,Wang Z,Dai J,Wang W,Zhang E,Guo R
200-02 was used in Cell Culture to reveal that B4GALT1 regulated LUAD cell proliferation and invasion both in vitro and in vivo and was related to the impaired antitumour capacity of CD8 + T cells.
Mon Jun 12 00:00:00 UTC 2023
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma.
Journal of experimental & clinical cancer research : CR
Cui Y,Li J,Zhang P,Yin D,Wang Z,Dai J,Wang W,Zhang E,Guo R
200-02 was used in Cell Culture to reveal that B4GALT1 regulated LUAD cell proliferation and invasion both in vitro and in vivo and was related to the impaired antitumour capacity of CD8 + T cells.
Mon Jun 12 00:00:00 UTC 2023
Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion.
Anticancer research
Lee DY,Kim Y,Park JS,Choi JU,Jeong HG,Park CH
200-02 was used in Cell Culture to develop feeder cells using synthetic biology techniques to obtain sufficient numbers of high-quality natural killer (NK) cells.
Fri Sep 01 00:00:00 UTC 2023
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
Nature cancer
Mandal K,Wicaksono G,Yu C,Adams JJ,Hoopmann MR,Temple WC,Izgutdina A,Escobar BP,Gorelik M,Ihling CH,Nix MA,Naik A,Xie WH,Hübner J,Rollins LA,Reid SM,Ramos E,Kasap C,Steri V,Serrano JAC,Salangsang F,Phojanakong P,McMillan M,Gavallos V,Leavitt AD,Logan AC,Rooney CM,Eyquem J,Sinz A,Huang BJ,Stieglitz E,Smith CC,Moritz RL,Sidhu SS,Huang L,Wiita AP
200-02 was used in Cell Culture to develop and characterize recombinant antibodies to this protein conformation and show that chimeric antigen receptor T cells eliminate acute myeloid leukemia (AML) cells and patient-derived xenografts without notable toxicity toward normal hematopoietic cells.
Wed Nov 01 00:00:00 UTC 2023
Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.
Frontiers in oncology
Babl N,Hofbauer J,Matos C,Voll F,Menevse AN,Rechenmacher M,Mair R,Beckhove P,Herr W,Siska PJ,Renner K,Kreutz M,Schnell A
200-02 was used in Cell Culture to investigate the effect of LDL on T cell activation and tumor immunity in-vitro.
Tue Feb 14 00:00:00 UTC 2023
Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1.
Journal of experimental & clinical cancer research : CR
Zhang Z,Yu Y,Zhang Z,Li D,Liang Z,Wang L,Chen Y,Liang Y,Niu H
200-02 was used in Cell Culture to reveal a novel mechanism for the role of CXCL12 in P62-mediated PDL1 autophagic regulation.
Sat Nov 25 00:00:00 UTC 2023
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance.
Cell reports. Medicine
Gerace D,Zhou Q,Kenty JH,Veres A,Sintov E,Wang X,Boulanger KR,Li H,Melton DA
200-02 was used in Cell Culture to show that targeting human leukocyte antigens (HLAs) and PD-L1 alone does not sufficiently protect SC-islet cells from xenograft (xeno)- or allograft (allo)-rejection.
Tue Jan 17 00:00:00 UTC 2023
Endogenous H3.3K27M derived peptide restricted to HLA-A∗02:01 is insufficient for immune-targeting in diffuse midline glioma.
Molecular therapy oncolytics
Wang SS,Pandey K,Watson KA,Abbott RC,Mifsud NA,Gracey FM,Ramarathinam SH,Cross RS,Purcell AW,Jenkins MR
200-02 was used in Cell Culture to suggest that targeting the H3 K27M26-35 mutation in context of HLA-A∗02:01 may not be a feasible immunotherapy strategy because of its lack of presentation.
Thu Sep 21 00:00:00 UTC 2023
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis.
Nature communications
Moon JS,Younis S,Ramadoss NS,Iyer R,Sheth K,Sharpe O,Rao NL,Becart S,Carman JA,James EA,Buckner JH,Deane KD,Holers VM,Goodman SM,Donlin LT,Davis MM,Robinson WH
200-02 was used in In vitro experiments to suggest that cytotoxic CD8+ T cells targeting citrullinated antigens contribute to synovitis and joint tissue destruction in ACPA+ RA.
Thu Jan 19 00:00:00 UTC 2023
TCR T cells overexpressing c-Jun have better functionality with improved tumor infiltration and persistence in hepatocellular carcinoma.
Frontiers in immunology
Hussein MS,Li Q,Mao R,Peng Y,He Y
200-02 was used in Cell Culture to study whether overexpression of c-Jun, a transcription factor required for T cell activation, in the TCR T cells could enhance their expansion, function, and persistence in hepatocellular carcinoma tumor models.
Wed May 24 00:00:00 UTC 2023
High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays.
Nature biomedical engineering
Ansaryan S,Liu YC,Li X,Economou AM,Eberhardt CS,Jandus C,Altug H
200-02 was used in In vitro experiments to describe a microwell array for the real-time spatiotemporal monitoring of extracellular secretions from hundreds of single cells in parallel.
Sat Jul 01 00:00:00 UTC 2023
Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment.
iScience
Wilson JJ,Wei J,Daamen AR,Sears JD,Bechtel E,Mayberry CL,Stafford GA,Bechtold L,Grammer AC,Lipsky PE,Roopenian DC,Chang CH
200-02 was used in Cell Culture to discover that in lupus, activated B cells, including germinal center B (GCB) cells, have remarkably high glycolytic requirement for survival over T cell populations, as demonstrated by increased metabolic activity in lupus-activated B cells compared to immunization-induced cells.
Fri Sep 15 00:00:00 UTC 2023
Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment.
iScience
Wilson JJ,Wei J,Daamen AR,Sears JD,Bechtel E,Mayberry CL,Stafford GA,Bechtold L,Grammer AC,Lipsky PE,Roopenian DC,Chang CH
200-02 was used in Cell Culture to discover that in lupus, activated B cells, including germinal center B (GCB) cells, have remarkably high glycolytic requirement for survival over T cell populations, as demonstrated by increased metabolic activity in lupus-activated B cells compared to immunization-induced cells.
Fri Sep 15 00:00:00 UTC 2023
CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.
Nature biotechnology
Petri K,Zhang W,Ma J,Schmidts A,Lee H,Horng JE,Kim DY,Kurt IC,Clement K,Hsu JY,Pinello L,Maus MV,Joung JK,Yeh JJ
200-02 was used in Cell Culture to show that in HEK293T and primary human T cells, prime editing with purified ribonucleoprotein complexes introduced desired edits with frequencies of up to 21 and 7.5%, respectively.
Tue Feb 01 00:00:00 UTC 2022
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.
Cell
Banskota S,Raguram A,Suh S,Du SW,Davis JR,Choi EH,Wang X,Nielsen SC,Newby GA,Randolph PB,Osborn MJ,Musunuru K,Palczewski K,Liu DR
Thu Jan 20 00:00:00 UTC 2022
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection.
Nature immunology
Di Pietro A,Polmear J,Cooper L,Damelang T,Hussain T,Hailes L,O'Donnell K,Udupa V,Mi T,Preston S,Shtewe A,Hershberg U,Turner SJ,La Gruta NL,Chung AW,Tarlinton DM,Scharer CD,Good-Jacobson KL
Sat Jan 01 00:00:00 UTC 2022
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts.
The Journal of experimental medicine
Kerdidani D,Aerakis E,Verrou KM,Angelidis I,Douka K,Maniou MA,Stamoulis P,Goudevenou K,Prados A,Tzaferis C,Ntafis V,Vamvakaris I,Kaniaris E,Vachlas K,Sepsas E,Koutsopoulos A,Potaris K,Tsoumakidou M
Mon Feb 07 00:00:00 UTC 2022
Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.
The Journal of experimental medicine
Liu G,Chen Y,Wang Y,Deng X,Xiao Q,Zhang L,Xu H,Han X,Lei A,He J,Li X,Cao Y,Zhou P,He C,Wu P,Jiang W,Tan M,Chen C,Yang Q,Lu L,Deng K,Yao Z,Zhou J
Mon Mar 07 00:00:00 UTC 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
200-02 was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 UTC 2022
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
200-02 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 UTC 2022
Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
EMBO molecular medicine
Letizia M,Wang YH,Kaufmann U,Gerbeth L,Sand A,Brunkhorst M,Weidner P,Ziegler JF,Böttcher C,Schlickeiser S,Fernández C,Yamashita M,Stauderman K,Sun K,Kunkel D,Prakriya M,Sanders A,Siegmund B,Feske S,Weidinger C
200-02 was used in Sample Preparation (FC/FACS) to indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.
Wed Sep 07 00:00:00 UTC 2022
NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes.
The EMBO journal
Fan J,Shi J,Zhang Y,Liu J,An C,Zhu H,Wu P,Hu W,Qin R,Yao D,Shou X,Xu Y,Tong Z,Wen X,Xu J,Zhang J,Fang W,Lou J,Yin W,Chen W
200-02 was used in Sample Preparation (FC/FACS) to study whether and how NKG2D recognizes and discriminates diverse ligands to elicit differential anti-tumor and anti-virus immune responses by characterizing the in situ binding kinetics of NKG2D interacting with different ligands in the absence and presence of mechanical force.
Sat Dec 17 00:00:00 UTC 2022
Epigenetic state determines inflammatory sensing in neuroblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Wolpaw AJ,Grossmann LD,Dessau JL,Dong MM,Aaron BJ,Brafford PA,Volgina D,Pascual-Pasto G,Rodriguez-Garcia A,Uzun Y,Arsenian-Henriksson M,Powell DJ,Bosse KR,Kossenkov A,Tan K,Hogarty MD,Maris JM,Dang CV
200-02 was used in In vitro experiments to investigate inflammatory signaling pathways in neuroblastoma which was found to rely on epigentic state of the tumor.
Tue Feb 08 00:00:00 UTC 2022
V-CARMA: A tool for the detection and modification of antigen-specific T cells.
Proceedings of the National Academy of Sciences of the United States of America
Guo XJ,Elledge SJ
Tue Jan 25 00:00:00 UTC 2022
CD81 costimulation skews CAR transduction toward naive T cells.
Proceedings of the National Academy of Sciences of the United States of America
Schultz LM,Czerwinski DK,Levy R,Levy S
Tue Feb 01 00:00:00 UTC 2022
CD81 costimulation skews CAR transduction toward naive T cells.
Proceedings of the National Academy of Sciences of the United States of America
Schultz LM,Czerwinski DK,Levy R,Levy S
Tue Feb 01 00:00:00 UTC 2022
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.
Cancer immunology research
Celus W,Oliveira AI,Rivis S,Van Acker HH,Landeloos E,Serneels J,Cafarello ST,Van Herck Y,Mastrantonio R,Köhler A,Garg AD,Flamand V,Tamagnone L,Marine JC,Di Matteo M,Costa BM,Bechter O,Mazzone M
200-02 was used in Cell Culture to show that expression of the axon guidance molecule Plexin-A4 (Plxna4) in cytotoxic T cells (CTLs), especially in effector/memory CD8+ T cells, is induced upon T-cell activation, sustained in the circulation, but reduced when entering the tumor bed and that upon deletion of Plxna4, CTLs acquire improved homing capacity to the lymph nodes and to the tumor.
Sat Jan 01 00:00:00 UTC 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
200-02 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 UTC 2022
Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination.
British journal of haematology
Riise J,Meyer S,Blaas I,Chopra A,Tran TT,Delic-Sarac M,Hestdalen ML,Brodin E,Rustad EH,Dai KZ,Vaage JT,Nissen-Meyer LSH,Sund F,Wader KF,Bjornevik AT,Meyer PA,Nygaard GO,König M,Smeland S,Lund-Johansen F,Olweus J,Kolstad A
Wed Jun 01 00:00:00 UTC 2022
Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants.
Genes & diseases
Hu C,Shen M,Han X,Chen Q,Li L,Chen S,Zhang J,Gao F,Wang W,Wang Y,Li T,Li S,Huang J,Wang J,Zhu J,Chen D,Wu Q,Tao K,Pang D,Jin A
Sat Jan 01 00:00:00 UTC 2022
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model.
Cancer gene therapy
Ng YY,Du Z,Zhang X,Chng WJ,Wang S
Sun May 01 00:00:00 UTC 2022
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model.
Cancer gene therapy
Ng YY,Du Z,Zhang X,Chng WJ,Wang S
Sun May 01 00:00:00 UTC 2022
Enhanced Calcium Signal Induces NK Cell Degranulation but Inhibits Its Cytotoxic Activity.
Journal of immunology (Baltimore, Md. : 1950)
Li Y,Yu M,Yin J,Yan H,Wang X
Sat Jan 15 00:00:00 UTC 2022
Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy.
Cancer research and treatment
Chen Y,Huang H,Liu Y,Wang Z,Wang L,Wang Q,Zhang Y,Wang H
200-02 was used in Cell Culture to optimize a peptide (nABP284) that binds to PD-1 by a computer-based protocol in order to increase its affinity.
Fri Apr 01 00:00:00 UTC 2022
Chimeric antigen receptor T cells targeting CD147 for non-small cell lung cancer therapy.
Translational oncology
Chen XH,Chen R,Shi MY,Tian RF,Zhang H,Xin ZQ,Chen ZN,Wang K
200-02 was used in Flow cytometry/Cell sorting to show that CD147-CART immunotherapy for NSCLC is safe and effective, which is an ideal and promising medical patch for treating NSCLC.
Tue Feb 01 00:00:00 UTC 2022
Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.
Journal of clinical laboratory analysis
Xu W,Li S,Li M,Zhou H,Yang X
200-02 was used in Cell Culture to investigate myeloid-derived suppressor cells in immunotherapy of cancer.
Sat Jan 01 00:00:00 UTC 2022
Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing.
Frontiers in medical technology
Gatla H,Uth N,Levinson Y,Navaei A,Sargent A,Ramaswamy S,Friedrich Ben-Nun I
200-02 was used in Cell activation to present a closed and scalable platform for T cell manufacturing to meet clinical demand.
Sat Jul 16 00:00:00 UTC 2022
Differential Effects on the Translation of Immune-Related Alternatively Polyadenylated mRNAs in Melanoma and T Cells by eIF4A Inhibition.
Cancers
Biswas B,Guemiri R,Cadix M,Labbé CM,Chakraborty A,Dutertre M,Robert C,Vagner S
200-02 was used in Sample Preparation (FC/FACS) to investigate molecular mechanisms of anti-cancer, implicating eIF4F,STAT1,and others.
Thu Feb 24 00:00:00 UTC 2022
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Cell metabolism
Hochrein SM,Wu H,Eckstein M,Arrigoni L,Herman JS,Schumacher F,Gerecke C,Rosenfeldt M,Grün D,Kleuser B,Gasteiger G,Kastenmüller W,Ghesquière B,Van den Bossche J,Abel ED,Vaeth M
200-02 was used in In vitro experiments to show that GLUT3-dependent glucose uptake controls a metabolic-transcriptional circuit that regulates the pathogenicity of Th17 cells.
Tue Apr 05 00:00:00 UTC 2022
Effect of JAK Inhibition on the Induction of Proinflammatory HLA-DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ.
Arthritis & rheumatology (Hoboken, N.J.)
Zhao S,Grieshaber-Bouyer R,Rao DA,Kolb P,Chen H,Andreeva I,Tretter T,Lorenz HM,Watzl C,Wabnitz G,Tykocinski LO,Merkt W
200-02 was used in Cell Culture to investigate the generation, function and therapeutically intended blockage of HLA-DR+CD90+ synovial fibroblasts.
Tue Mar 01 00:00:00 UTC 2022
Shear Stress Enhances the Paracrine-Mediated Immunoregulatory Function of Human Periodontal Ligament Stem Cells via the ERK Signalling Pathway.
International journal of molecular sciences
Suwittayarak R,Klincumhom N,Ngaokrajang U,Namangkalakul W,Ferreira JN,Pavasant P,Osathanon T
200-02 was used in In vitro experiments to reveals that shear stress increased messanger ribonucleic acid (mRNA) expression of indoleamine 2,3-deoxygenase (IDO) and cyclooxygenase-2 (COX2) but not transforming growth factor beta-1 (TGF-β1) and interferon gamma (IFN-γ).
Mon Jun 27 00:00:00 UTC 2022
Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.
Nature communications
Chang HF,Schirra C,Ninov M,Hahn U,Ravichandran K,Krause E,Becherer U,Bálint Š,Harkiolaki M,Urlaub H,Valitutti S,Baldari CT,Dustin ML,Jahn R,Rettig J
200-02 was used in Cell Culture to propose that CTLs use SCG fusion to fill the synaptic cleft with active cytotoxic proteins instantly and parallel MCG fusion to deliver latent SMAPs for delayed killing of refractory targets.
Thu Feb 24 00:00:00 UTC 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.
Frontiers in immunology
Ng L,Wang X,Yang C,Su C,Li M,Cheung AKL
200-02 was used in Cell Culture to conclude that regulating the intracellular trafficking/processing of α-syn by DCs can be a potential approach to control the progression of PD, in which Celastrol is a potential candidate to accomplish this.
Mon May 02 00:00:00 UTC 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
200-02 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 UTC 2022
Predicting T-cell quality during manufacturing through an artificial intelligence-based integrative multiomics analytical platform.
Bioengineering & translational medicine
Odeh-Couvertier VY,Dwarshuis NJ,Colonna MB,Levine BL,Edison AS,Kotanchek T,Roy K,Torres-Garcia W
200-02 was used in Cell Culture to investigate computational models for reliable therapeutic cell production.
Sun May 01 00:00:00 UTC 2022
Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections.
Cell reports. Medicine
Chandran A,Rosenheim J,Nageswaran G,Swadling L,Pollara G,Gupta RK,Burton AR,Guerra-Assunção JA,Woolston A,Ronel T,Pade C,Gibbons JM,Sanz-Magallon Duque De Estrada B,Robert de Massy M,Whelan M,Semper A,Brooks T,Altmann DM,Boyton RJ,McKnight Á,Captur G,Manisty C,Treibel TA,Moon JC,Tomlinson GS,Maini MK,Chain BM,Noursadeghi M
200-02 was used in Cell Culture to support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines.
Tue Mar 15 00:00:00 UTC 2022
Discovery and validation of human genomic safe harbor sites for gene and cell therapies.
Cell reports methods
Aznauryan E,Yermanos A,Kinzina E,Devaux A,Kapetanovic E,Milanova D,Church GM,Reddy ST
200-02 was used in Cell Culture to investigate methods of gene editing in humans.
Mon Jan 24 00:00:00 UTC 2022
USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.
The EMBO journal
Xie F,Zhou X,Li H,Su P,Liu S,Li R,Zou J,Wei X,Pan C,Zhang Z,Zheng M,Liu Z,Meng X,Ovaa H,Ten Dijke P,Zhou F,Zhang L
200-02 was used in Cell Culture to demonstrate the therapeutic advantages of engineering USP8 inhibitors to simultaneously suppress metastasis and improve the efficacy of cancer immunotherapy.
Tue Aug 16 00:00:00 UTC 2022
Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.
Cell reports
Cortes JR,Filip I,Albero R,Patiño-Galindo JA,Quinn SA,Lin WW,Laurent AP,Shih BB,Brown JA,Cooke AJ,Mackey A,Einson J,Zairis S,Rivas-Delgado A,Laginestra MA,Pileri S,Campo E,Bhagat G,Ferrando AA,Rabadan R,Palomero T
200-02 was used in Cell Culture to study the specific role and mechanism of peripheral T cell lymphoma not otherwise specified (PTCL-NOS).
Tue Apr 19 00:00:00 UTC 2022
Simultaneous Genetic Ablation of PD-1, LAG-3, and TIM-3 in CD8 T Cells Delays Tumor Growth and Improves Survival Outcome.
International journal of molecular sciences
Ciraolo E,Althoff S,Ruß J,Rosnev S,Butze M,Pühl M,Frentsch M,Bullinger L,Na IK
200-02 was used in Cell Culture to suggest that antigen-specific adoptive T cell therapy with concomitant genetic disruption of multiple checkpoint inhibitory receptors could represent an effective antitumor immunotherapy approach with improved tolerability profile.
Wed Mar 16 00:00:00 UTC 2022
High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer.
iScience
Ke S,Xie F,Guo Y,Chen J,Wang Z,Yu Y,Geng H,Xu D,Liu X,Xia X,Yu F,Zhu C,Zhang Z,Zhao G,Li B,Zhao W
200-02 was used in Cell Culture to analyze single-cell RNA sequencing (scRNA-seq) data of human gastric cancer (GC) and use flow to explore the glucocorticoid-induced TNFR-related protein expression across T cell subsets and tissue types in GC patients.
Thu Dec 22 00:00:00 UTC 2022
Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability.
Frontiers in immunology
Hu JF,Wang ZW,Liao CY,Chen ZW,Kang FP,Lin CF,Lin TS,Huang L,Tian YF,Chen S
200-02 was used in Cell Culture to demonstrate that mesoCAR-N19 can be specifically expressed in CAR-T cells activated by tumor cells compared with conventional mesothelin CAR-T (mesoCAR) cells.
Tue Aug 23 00:00:00 UTC 2022
The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas.
Cancer prevention research (Philadelphia, Pa.)
Wei J,Zhang J,Wang D,Cen B,Lang JD,DuBois RN
200-02 was used in Cell Culture to provide a potential explanation underlying the chemopreventive effect of NSAIDs on reducing colorectal cancer incidence during premalignancy and provide a rationale for developing EP4 antagonists for colorectal cancer prevention and treatment.
Tue May 03 00:00:00 UTC 2022
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
The Journal of general physiology
Wang L,Noyer L,Wang YH,Tao AY,Li W,Zhu J,Saavedra P,Hoda ST,Yang J,Feske S
200-02 was used in In vitro experiments to investigate the plasma membrane protein ORAI3 function in immune cells in mice.
Mon Oct 03 00:00:00 UTC 2022
Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance.
iScience
Choe YJ,Min JY,Lee H,Lee SY,Kwon J,Kim HJ,Lee J,Kim HM,Park HS,Cho MY,Hyun JY,Kim HM,Chung YH,Ha SK,Jeong HG,Choi I,Kim TD,Hong KS,Han EH
200-02 was used in Cell Culture to investigate CIC structures of cancer and immune cells in drug resistance.
Fri Sep 16 00:00:00 UTC 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
200-02 was used in In vitro experiments to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.
Mon Aug 01 00:00:00 UTC 2022
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Clinical and translational medicine
Zhang Z,Ji W,Huang J,Zhang Y,Zhou Y,Zhang J,Dong Y,Yuan T,Yang Q,Ding X,Tang L,Li H,Yin J,Wang Y,Ji T,Fei J,Zhang B,Chen P,Hu H
200-02 was used in In vitro experiments to study the cellular contexts of malignant pleural effusion (MPE) to provide a novel cellular atlas of MPE and primary tumour (PT) in patients with advanced osteosarcoma.
Tue Nov 01 00:00:00 UTC 2022
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
Life science alliance
Schneider MM,Emmenegger M,Xu CK,Condado Morales I,Meisl G,Turelli P,Zografou C,Zimmermann MR,Frey BM,Fiedler S,Denninger V,Jacquat RP,Madrigal L,Ilsley A,Kosmoliaptsis V,Fiegler H,Trono D,Knowles TP,Aguzzi A
Tue Feb 01 00:00:00 UTC 2022
Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection.
Science advances
Wang YH,Noyer L,Kahlfuss S,Raphael D,Tao AY,Kaufmann U,Zhu J,Mitchell-Flack M,Sidhu I,Zhou F,Vaeth M,Thomas PG,Saunders SP,Stauderman K,Curotto de Lafaille MA,Feske S
200-02 was used in Cell Culture to investigate how store-operated Ca2+ entry controls T cell function in pulmonary inflammation during a T helper 1 (TH1) cell-mediated response to influenza A virus (IAV) infection and TH2 cell-mediated allergic airway inflammation.
Fri Oct 07 00:00:00 UTC 2022
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.
Cell reports
McMurray JL,von Borstel A,Taher TE,Syrimi E,Taylor GS,Sharif M,Rossjohn J,Remmerswaal EBM,Bemelman FJ,Vieira Braga FA,Chen X,Teichmann SA,Mohammed F,Berry AA,Lyke KE,Williamson KC,Stubbington MJT,Davey MS,Willcox CR,Willcox BE
200-02 was used in Cell Culture to show that adult Vδ1+ T cells segregate into TCF7+LEF1+Granzyme Bneg (Tnaive) or T-bet+Eomes+BLIMP-1+Granzyme B+.
Tue May 24 00:00:00 UTC 2022
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.
Immunity
Giles JR,Manne S,Freilich E,Oldridge DA,Baxter AE,George S,Chen Z,Huang H,Chilukuri L,Carberry M,Giles L,Weng NP,Young RM,June CH,Schuchter LM,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Huang AC,Shi J,Wherry EJ
200-02 was used in In vitro experiments to define epigenetic and transcriptional regulation of human T cells and illustrate the utility of interrogating disease in the context of a healthy T cell atlas.
Tue Mar 08 00:00:00 UTC 2022
Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim S,Nam H,Cha B,Park J,Sung HJ,Jeon JS
Wed Jun 01 00:00:00 UTC 2022
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Nature communications
Erdogmus S,Concepcion AR,Yamashita M,Sidhu I,Tao AY,Li W,Rocha PP,Huang B,Garippa R,Lee B,Lee A,Hell JW,Lewis RS,Prakriya M,Feske S
200-02 was used in Sample Preparation (FC/FACS) to demonstrate that although CaVβ1 regulates T cell function, these effects are independent of VGCC channel activity.
Tue Apr 19 00:00:00 UTC 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
200-02 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 UTC 2022
Blocking LAIR1 signaling in immune cells inhibits tumor development.
Frontiers in immunology
Xie J,Gui X,Deng M,Chen H,Chen Y,Liu X,Ku Z,Tan L,Huang R,He Y,Zhang B,Lewis C,Chen K,Xu L,Xu J,Huang T,Liao XC,Zhang N,An Z,Zhang CC
200-02 was used in In vitro experiments to suggest that blocking LAIR1 signaling with antagonist antibodies represents a new attractive anticancer strategy.
Tue Oct 11 00:00:00 UTC 2022
Shuterin Enhances the Cytotoxicity of the Natural Killer Leukemia Cell Line KHYG-1 by Increasing the Expression Levels of Granzyme B and IFN-γ through the MAPK and Ras/Raf Signaling Pathways.
International journal of molecular sciences
Lin JT,Chuang YC,Chen MK,Lo YS,Lin CC,Ho HY,Liu YT,Hsieh MJ
200-02 was used in Cell Culture to explore the possible capacity of shuterin to enhance the proliferation and activity of KHYG-1 cells (an NK leukemia cell line).
Mon Oct 24 00:00:00 UTC 2022
Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques.
Microbial biotechnology
Wang H,Li P,Zhang M,Bi J,He Y,Li F,Yu R,Gao F,Kong W,Yu B,Chen L,Yu X
Fri Jul 01 00:00:00 UTC 2022
Temporal Expression of Transcription Factor ID2 Improves Natural Killer Cell Differentiation from Human Pluripotent Stem Cells.
ACS synthetic biology
Jung J,Chang Y,Jin G,Lian X,Bao X
200-02 was used in Cell Culture to genetically engineer human pluripotent stem cells with inducible overexpression of transcription factors via CRISPR/Cas9-mediated gene knock-in and investigate their temporal roles during NK cell differentiation.
Fri Jun 17 00:00:00 UTC 2022
Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15.
Cytokine
MacMullan MA,Wang P,Graham NA
200-02 was used in In vitro experiments to compare the early signalling dynamics induced by the cytokines interleukin (IL)-2 and IL-15 using liquid chromatography-mass spectrometry-based phospho-proteomics in NK-92 cells.
Thu Sep 01 00:00:00 UTC 2022
Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability.
Frontiers in oncology
Yu G,Wang W,He X,Xu J,Xu R,Wan T,Wu Y
200-02 was used in Cell Culture to show that NY-ESO-1 TCR-T cell therapy could inhibit A375 tumor growth and prolonged the survival time.
Sat Jul 16 00:00:00 UTC 2022
Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.
STAR protocols
Moosmann C,Müller TR,Busch DH,Schober K
Fri Mar 18 00:00:00 UTC 2022
Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).
Frontiers in immunology
Ogbechi J,Huang YS,Clanchy FIL,Pantazi E,Topping LM,Darlington LG,Williams RO,Stone TW
200-02 was used in Sample Preparation (FC/FACS) to study the ability of Pseudomonas Quorum Sensor (PQS) to influence cytokine expression under conditions of inflammatory stress to show that PQS decreased the expression of indoleamine-2, 3-dioxygenase genes (IDO1 and IDO2), IDO1 protein expression and enzyme activity in mouse and human macrophages.
Mon Nov 21 00:00:00 UTC 2022
Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers.
iScience
Li YR,Zeng S,Dunn ZS,Zhou Y,Li Z,Yu J,Wang YC,Ku J,Cook N,Kramer A,Yang L
200-02 was used in In vitro experiments to report the successful generation of third-party HSC-engineered human iNKT (3rdHSC-iNKT) cells using a method combining HSC gene engineering and in vitro HSC differentiation.
Fri Sep 16 00:00:00 UTC 2022
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
Nature medicine
Ogishi M,Yang R,Aytekin C,Langlais D,Bourgey M,Khan T,Ali FA,Rahman M,Delmonte OM,Chrabieh M,Zhang P,Gruber C,Pelham SJ,Spaan AN,Rosain J,Lei WT,Drutman S,Hellmann MD,Callahan MK,Adamow M,Wong P,Wolchok JD,Rao G,Ma CS,Nakajima Y,Yaguchi T,Chamoto K,Williams SC,Emile JF,Rozenberg F,Glickman MS,Rapaport F,Kerner G,Allington G,Tezcan I,Cagdas D,Hosnut FO,Dogu F,Ikinciogullari A,Rao VK,Kainulainen L,Béziat V,Bustamante J,Vilarinho S,Lifton RP,Boisson B,Abel L,Bogunovic D,Marr N,Notarangelo LD,Tangye SG,Honjo T,Gros P,Boisson-Dupuis S,Casanova JL
200-02 was used in Cell Culture to highlight the indispensable role of human PD-1 in governing both antimycobacterial immunity and self-tolerance, while identifying potentially actionable molecular targets for the diagnostic and therapeutic management of TB and autoimmunity in patients on PD-1 blockade.
Wed Sep 01 00:00:00 UTC 2021
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
Nature medicine
Ogishi M,Yang R,Aytekin C,Langlais D,Bourgey M,Khan T,Ali FA,Rahman M,Delmonte OM,Chrabieh M,Zhang P,Gruber C,Pelham SJ,Spaan AN,Rosain J,Lei WT,Drutman S,Hellmann MD,Callahan MK,Adamow M,Wong P,Wolchok JD,Rao G,Ma CS,Nakajima Y,Yaguchi T,Chamoto K,Williams SC,Emile JF,Rozenberg F,Glickman MS,Rapaport F,Kerner G,Allington G,Tezcan I,Cagdas D,Hosnut FO,Dogu F,Ikinciogullari A,Rao VK,Kainulainen L,Béziat V,Bustamante J,Vilarinho S,Lifton RP,Boisson B,Abel L,Bogunovic D,Marr N,Notarangelo LD,Tangye SG,Honjo T,Gros P,Boisson-Dupuis S,Casanova JL
200-02 was used in Cell Culture to highlight the indispensable role of human PD-1 in governing both antimycobacterial immunity and self-tolerance, while identifying potentially actionable molecular targets for the diagnostic and therapeutic management of TB and autoimmunity in patients on PD-1 blockade.
Wed Sep 01 00:00:00 UTC 2021
Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer.
Nature
Eberhardt CS,Kissick HT,Patel MR,Cardenas MA,Prokhnevska N,Obeng RC,Nasti TH,Griffith CC,Im SJ,Wang X,Shin DM,Carrington M,Chen ZG,Sidney J,Sette A,Saba NF,Wieland A,Ahmed R
Wed Sep 01 00:00:00 UTC 2021
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Cell
Koikawa K,Kibe S,Suizu F,Sekino N,Kim N,Manz TD,Pinch BJ,Akshinthala D,Verma A,Gaglia G,Nezu Y,Ke S,Qiu C,Ohuchida K,Oda Y,Lee TH,Wegiel B,Clohessy JG,London N,Santagata S,Wulf GM,Hidalgo M,Muthuswamy SK,Nakamura M,Gray NS,Zhou XZ,Lu KP
Thu Sep 02 00:00:00 UTC 2021
The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell
Dejnirattisai W,Zhou D,Ginn HM,Duyvesteyn HME,Supasa P,Case JB,Zhao Y,Walter TS,Mentzer AJ,Liu C,Wang B,Paesen GC,Slon-Campos J,López-Camacho C,Kafai NM,Bailey AL,Chen RE,Ying B,Thompson C,Bolton J,Fyfe A,Gupta S,Tan TK,Gilbert-Jaramillo J,James W,Knight M,Carroll MW,Skelly D,Dold C,Peng Y,Levin R,Dong T,Pollard AJ,Knight JC,Klenerman P,Temperton N,Hall DR,Williams MA,Paterson NG,Bertram FKR,Siebert CA,Clare DK,Howe A,Radecke J,Song Y,Townsend AR,Huang KA,Fry EE,Mongkolsapaya J,Diamond MS,Ren J,Stuart DI,Screaton GR
Thu Apr 15 00:00:00 UTC 2021
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.
Cell
Mathewson ND,Ashenberg O,Tirosh I,Gritsch S,Perez EM,Marx S,Jerby-Arnon L,Chanoch-Myers R,Hara T,Richman AR,Ito Y,Pyrdol J,Friedrich M,Schumann K,Poitras MJ,Gokhale PC,Gonzalez Castro LN,Shore ME,Hebert CM,Shaw B,Cahill HL,Drummond M,Zhang W,Olawoyin O,Wakimoto H,Rozenblatt-Rosen O,Brastianos PK,Liu XS,Jones PS,Cahill DP,Frosch MP,Louis DN,Freeman GJ,Ligon KL,Marson A,Chiocca EA,Reardon DA,Regev A,Suvà ML,Wucherpfennig KW
Thu Mar 04 00:00:00 UTC 2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
200-02 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 UTC 2021
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Cell
Sokal A,Chappert P,Barba-Spaeth G,Roeser A,Fourati S,Azzaoui I,Vandenberghe A,Fernandez I,Meola A,Bouvier-Alias M,Crickx E,Beldi-Ferchiou A,Hue S,Languille L,Michel M,Baloul S,Noizat-Pirenne F,Luka M,Mégret J,Ménager M,Pawlotsky JM,Fillatreau S,Rey FA,Weill JC,Reynaud CA,Mahévas M
Thu Mar 04 00:00:00 UTC 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 UTC 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 UTC 2021
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Cell
Chen PJ,Hussmann JA,Yan J,Knipping F,Ravisankar P,Chen PF,Chen C,Nelson JW,Newby GA,Sahin M,Osborn MJ,Weissman JS,Adamson B,Liu DR
Thu Oct 28 00:00:00 UTC 2021
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection.
Immunity
Gabriel SS,Tsui C,Chisanga D,Weber F,Llano-León M,Gubser PM,Bartholin L,Souza-Fonseca-Guimaraes F,Huntington ND,Shi W,Utzschneider DT,Kallies A
Tue Aug 10 00:00:00 UTC 2021
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Immunity
Sokal A,Barba-Spaeth G,Fernández I,Broketa M,Azzaoui I,de La Selle A,Vandenberghe A,Fourati S,Roeser A,Meola A,Bouvier-Alias M,Crickx E,Languille L,Michel M,Godeau B,Gallien S,Melica G,Nguyen Y,Zarrouk V,Canoui-Poitrine F,Pirenne F,Mégret J,Pawlotsky JM,Fillatreau S,Bruhns P,Rey FA,Weill JC,Reynaud CA,Chappert P,Mahévas M
Tue Dec 14 00:00:00 UTC 2021
Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease.
Immunity
Huang LJ,Mao XT,Li YY,Liu DD,Fan KQ,Liu RB,Wu TT,Wang HL,Zhang Y,Yang B,Ye CQ,Zhong JY,Chai RJ,Cao Q,Jin J
Tue Aug 10 00:00:00 UTC 2021
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.
Immunity
Pan YG,Aiamkitsumrit B,Bartolo L,Wang Y,Lavery C,Marc A,Holec PV,Rappazzo CG,Eilola T,Gimotty PA,Hensley SE,Antia R,Zarnitsyna VI,Birnbaum ME,Su LF
200-02 was used in In vitro experiments to examine how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus vaccine.
Tue Jun 08 00:00:00 UTC 2021
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.
Immunity
Chiou SH,Tseng D,Reuben A,Mallajosyula V,Molina IS,Conley S,Wilhelmy J,McSween AM,Yang X,Nishimiya D,Sinha R,Nabet BY,Wang C,Shrager JB,Berry MF,Backhus L,Lui NS,Wakelee HA,Neal JW,Padda SK,Berry GJ,Delaidelli A,Sorensen PH,Sotillo E,Tran P,Benson JA,Richards R,Labanieh L,Klysz DD,Louis DM,Feldman SA,Diehn M,Weissman IL,Zhang J,Wistuba II,Futreal PA,Heymach JV,Garcia KC,Mackall CL,Davis MM
Tue Mar 09 00:00:00 UTC 2021
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Immunity
Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C
Tue Apr 13 00:00:00 UTC 2021
Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Immunity
Yan Y,Ramanan D,Rozenberg M,McGovern K,Rastelli D,Vijaykumar B,Yaghi O,Voisin T,Mosaheb M,Chiu I,Itzkovitz S,Rao M,Mathis D,Benoist C
Tue Mar 09 00:00:00 UTC 2021
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Cancer cell
Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I
Mon Jun 14 00:00:00 UTC 2021
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
Wed Jun 23 00:00:00 UTC 2021
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.
Cell metabolism
Li C,Wang G,Sivasami P,Ramirez RN,Zhang Y,Benoist C,Mathis D
200-02 was used in Cell Culture to show that these cells were directly toxic to PPARγ+ VAT-Tregs.
Tue Aug 03 00:00:00 UTC 2021
A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1.
Cell host & microbe
Li W,Hang S,Fang Y,Bae S,Zhang Y,Zhang M,Wang G,McCurry MD,Bae M,Paik D,Franzosa EA,Rastinejad F,Huttenhower C,Yao L,Devlin AS,Huh JR
Wed Sep 08 00:00:00 UTC 2021
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Cell host & microbe
Bou-Nader C,Muecksch F,Brown JB,Gordon JM,York A,Peng C,Ghirlando R,Summers MF,Bieniasz PD,Zhang J
Wed Sep 08 00:00:00 UTC 2021
The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr.
Cell host & microbe
Dupont L,Bloor S,Williamson JC,Cuesta SM,Shah R,Teixeira-Silva A,Naamati A,Greenwood EJD,Sarafianos SG,Matheson NJ,Lehner PJ
Wed May 12 00:00:00 UTC 2021
Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
Nature immunology
Yao Y,Chen Z,Zhang H,Chen C,Zeng M,Yunis J,Wei Y,Wan Y,Wang N,Zhou M,Qiu C,Zeng Q,Ong HS,Wang H,Makota FV,Yang Y,Yang Z,Wang N,Deng J,Shen C,Xia Y,Yuan L,Lian Z,Deng Y,Guo C,Huang A,Zhou P,Shi H,Zhang W,Yi H,Li D,Xia M,Fu J,Wu N,de Haan JB,Shen N,Zhang W,Liu Z,Yu D
Wed Sep 01 00:00:00 UTC 2021
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.
Blood
Zheng W,Wei J,Zebley CC,Jones LL,Dhungana Y,Wang YD,Mavuluri J,Long L,Fan Y,Youngblood B,Chi H,Geiger TL
Thu Jul 15 00:00:00 UTC 2021
Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.
The Journal of clinical investigation
Harro CM,Perez-Sanz J,Costich TL,Payne KK,Anadon CM,Chaurio RA,Biswas S,Mandal G,Rigolizzo KE,Sprenger KB,Mine JA,Showe LC,Yu X,Liu K,Rodriguez PC,Pinilla-Ibarz J,Sokol L,Conejo-Garcia JR
Mon Feb 01 00:00:00 UTC 2021
Human skin is colonized by T cells that recognize CD1a independently of lipid.
The Journal of clinical investigation
Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB
Mon Jan 04 00:00:00 UTC 2021
Histone deficiency and accelerated replication stress in T cell aging.
The Journal of clinical investigation
Kim C,Jin J,Ye Z,Jadhav RR,Gustafson CE,Hu B,Cao W,Tian L,Weyand CM,Goronzy JJ
Tue Jun 01 00:00:00 UTC 2021
BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease.
The Journal of clinical investigation
Gonzalez MM,Bamidele AO,Svingen PA,Sagstetter MR,Smyrk TC,Gaballa JM,Hamdan FH,Kosinsky RL,Gibbons HR,Sun Z,Ye Z,Nair A,Ramos GP,Braga Neto MB,Wixom AQ,Mathison AJ,Johnsen SA,Urrutia R,Faubion WA
Tue Jun 15 00:00:00 UTC 2021
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus.
The Journal of clinical investigation
Vlahava VM,Murrell I,Zhuang L,Aicheler RJ,Lim E,Miners KL,Ladell K,Suárez NM,Price DA,Davison AJ,Wilkinson GW,Wills MR,Weekes MP,Wang EC,Stanton RJ
Mon Feb 15 00:00:00 UTC 2021
Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity.
The Journal of experimental medicine
Zong X,Hao X,Xu B,Crawford JC,Wright S,Li J,Zhang Y,Bai L,He M,Jiang M,Fan Y,Connelly JP,Pruett-Miller SM,Berns H,Janke L,Li C,Feng Y
Mon Aug 02 00:00:00 UTC 2021
CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
The Journal of experimental medicine
Cotton RN,Wegrecki M,Cheng TY,Chen YL,Veerapen N,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis R,Altman JD,de Jong A,Van Rhijn I,Clark RA,Besra GS,Ogg G,Rossjohn J,Moody DB
Mon Jul 05 00:00:00 UTC 2021
αβγδ T cells play a vital role in fetal human skin development and immunity.
The Journal of experimental medicine
Reitermaier R,Krausgruber T,Fortelny N,Ayub T,Vieyra-Garcia PA,Kienzl P,Wolf P,Scharrer A,Fiala C,Kölz M,Hiess M,Vierhapper M,Schuster C,Spittler A,Worda C,Weninger W,Bock C,Eppel W,Elbe-Bürger A
Mon Apr 05 00:00:00 UTC 2021
Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
The Journal of experimental medicine
Lev A,Lee YN,Sun G,Hallumi E,Simon AJ,Zrihen KS,Levy S,Beit Halevi T,Papazian M,Shwartz N,Somekh I,Levy-Mendelovich S,Wolach B,Gavrieli R,Vernitsky H,Barel O,Javasky E,Stauber T,Ma CA,Zhang Y,Amariglio N,Rechavi G,Hendel A,Yablonski D,Milner JD,Somech R
Mon Mar 01 00:00:00 UTC 2021
Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.
The Journal of experimental medicine
Xu H,Wu L,Nguyen HH,Mesa KR,Raghavan V,Episkopou V,Littman DR
Mon Nov 01 00:00:00 UTC 2021
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
Mon Feb 01 00:00:00 UTC 2021
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
The Journal of experimental medicine
Lu X,Hosono Y,Nagae M,Ishizuka S,Ishikawa E,Motooka D,Ozaki Y,Sax N,Maeda Y,Kato Y,Morita T,Shinnakasu R,Inoue T,Onodera T,Matsumura T,Shinkai M,Sato T,Nakamura S,Mori S,Kanda T,Nakayama EE,Shioda T,Kurosaki T,Takeda K,Kumanogoh A,Arase H,Nakagami H,Yamashita K,Takahashi Y,Yamasaki S
Mon Dec 06 00:00:00 UTC 2021
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
The Journal of experimental medicine
Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F
Mon Jan 04 00:00:00 UTC 2021
Single-cell imaging of T cell immunotherapy responses in vivo.
The Journal of experimental medicine
Yan C,Yang Q,Zhang S,Millar DG,Alpert EJ,Do D,Veloso A,Brunson DC,Drapkin BJ,Stanzione M,Scarfò I,Moore JC,Iyer S,Qin Q,Wei Y,McCarthy KM,Rawls JF,Dyson NJ,Cobbold M,Maus MV,Langenau DM
Mon Oct 04 00:00:00 UTC 2021
The SIRPα-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S
Mon Mar 01 00:00:00 UTC 2021
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
The Journal of experimental medicine
Pieters T,T'Sas S,Vanhee S,Almeida A,Driege Y,Roels J,Van Loocke W,Daneels W,Baens M,Marchand A,Van Trimpont M,Matthijssens F,Morscio J,Lemeire K,Lintermans B,Reunes L,Chaltin P,Offner F,Van Dorpe J,Hochepied T,Berx G,Beyaert R,Staal J,Van Vlierberghe P,Goossens S
Mon Oct 04 00:00:00 UTC 2021
A robust platform for expansion and genome editing of primary human natural killer cells.
The Journal of experimental medicine
Huang RS,Lai MC,Shih HA,Lin S
Mon Mar 01 00:00:00 UTC 2021
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome.
The Journal of experimental medicine
Stackowicz J,Gaudenzio N,Serhan N,Conde E,Godon O,Marichal T,Starkl P,Balbino B,Roers A,Bruhns P,Jönsson F,Moguelet P,Georgin-Lavialle S,Broderick L,Hoffman HM,Galli SJ,Reber LL
Mon Oct 04 00:00:00 UTC 2021
T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.
The Journal of experimental medicine
Kuehn HS,Chang J,Yamashita M,Niemela JE,Zou C,Okuyama K,Harada J,Stoddard JL,Nunes-Santos CJ,Boast B,Baxter RM,Hsieh EWY,Garofalo M,Fleisher TA,Morio T,Taniuchi I,Dutmer CM,Rosenzweig SD
Mon Dec 06 00:00:00 UTC 2021
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.
The Journal of experimental medicine
Lee-Chang C,Miska J,Hou D,Rashidi A,Zhang P,Burga RA,Jusué-Torres I,Xiao T,Arrieta VA,Zhang DY,Lopez-Rosas A,Han Y,Sonabend AM,Horbinski CM,Stupp R,Balyasnikova IV,Lesniak MS
Mon Jan 04 00:00:00 UTC 2021
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.
The Journal of experimental medicine
Lee-Chang C,Miska J,Hou D,Rashidi A,Zhang P,Burga RA,Jusué-Torres I,Xiao T,Arrieta VA,Zhang DY,Lopez-Rosas A,Han Y,Sonabend AM,Horbinski CM,Stupp R,Balyasnikova IV,Lesniak MS
Mon Jan 04 00:00:00 UTC 2021
Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.
Arthritis & rheumatology (Hoboken, N.J.)
Vecellio M,Chen L,Cohen CJ,Cortes A,Li Y,Bonham S,Selmi C,Brown MA,Fischer R,Knight JC,Wordsworth BP
Tue Jun 01 00:00:00 UTC 2021
NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development.
EMBO molecular medicine
Tsai HI,Zeng X,Liu L,Xin S,Wu Y,Xu Z,Zhang H,Liu G,Bi Z,Su D,Yang M,Tao Y,Wang C,Zhao J,Eriksson JE,Deng W,Cheng F,Chen H
Fri Mar 05 00:00:00 UTC 2021
Immunodynamics of explanted human tumors for immuno-oncology.
EMBO molecular medicine
Dubuisson A,Fahrner JE,Goubet AG,Terrisse S,Voisin N,Bayard C,Lofek S,Drubay D,Bredel D,Mouraud S,Susini S,Cogdill A,Rebuffet L,Ballot E,Jacquelot N,Thomas de Montpreville V,Casiraghi O,Radulescu C,Ferlicot S,Figueroa DJ,Yadavilli S,Waight JD,Ballas M,Hoos A,Condamine T,Parier B,Gaudillat C,Routy B,Ghiringhelli F,Derosa L,Breuskin I,Rouanne M,André F,Lebacle C,Baumert H,Wislez M,Fadel E,Cremer I,Albiges L,Geoerger B,Scoazec JY,Loriot Y,Kroemer G,Marabelle A,Bonvalet M,Zitvogel L
Mon Jan 11 00:00:00 UTC 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 UTC 2021
Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection.
EMBO molecular medicine
Huang KY,Lin MS,Kuo TC,Chen CL,Lin CC,Chou YC,Chao TL,Pang YH,Kao HC,Huang RS,Lin S,Chang SY,Yang PC
Mon Jan 11 00:00:00 UTC 2021
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
The EMBO journal
Robles-Valero J,Fernández-Nevado L,Lorenzo-Martín LF,Cuadrado M,Fernández-Pisonero I,Rodríguez-Fdez S,Astorga-Simón EN,Abad A,Caloto R,Bustelo XR
200-02 was used in Sample Preparation (FC/FACS) to reveal the genetic constraints associated with the lymphomagenic potential of VAV1 mutant subsets, similarities with other PTCL driver genes, and potential therapeutic vulnerabilities.
Mon Nov 15 00:00:00 UTC 2021
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
The EMBO journal
Robles-Valero J,Fernández-Nevado L,Lorenzo-Martín LF,Cuadrado M,Fernández-Pisonero I,Rodríguez-Fdez S,Astorga-Simón EN,Abad A,Caloto R,Bustelo XR
200-02 was used in Sample Preparation (FC/FACS) to reveal the genetic constraints associated with the lymphomagenic potential of VAV1 mutant subsets, similarities with other PTCL driver genes, and potential therapeutic vulnerabilities.
Mon Nov 15 00:00:00 UTC 2021
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.
Autophagy
Yang G,Song W,Postoak JL,Chen J,Martinez J,Zhang J,Wu L,Van Kaer L
200-02 was used in Cell Culture to study the contribution of PIK3C3 to T cell metabolism and function to show that Pik3c3-deficient T cells exhibit impaired cellular metabolism, and that Pik3c3-deficient CD4+ T cells fail to differentiate into T helper 1 cells, changes which are associated with reduced levels of active mitochondria upon T cell activation.
Sat May 01 00:00:00 UTC 2021
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Chen Y,Li Y,Huang F,Luo B,Yuan Y,Xia B,Ma X,Yang T,Yu F,Liu J,Liu B,Song Z,Chen J,Yan S,Wu L,Pan T,Zhang X,Li R,Huang W,He X,Xiao F,Zhang J,Zhang H
Tue Jun 08 00:00:00 UTC 2021
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice.
Proceedings of the National Academy of Sciences of the United States of America
Nakajima Y,Chamoto K,Oura T,Honjo T
Tue Jun 08 00:00:00 UTC 2021
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Proceedings of the National Academy of Sciences of the United States of America
Clement M,Knezevic L,Dockree T,McLaren JE,Ladell K,Miners KL,Llewellyn-Lacey S,Rubina A,Francis O,Cole DK,Sewell AK,Bridgeman JS,Price DA,van den Berg HA,Wooldridge L
Tue Jul 20 00:00:00 UTC 2021
Functional heterogeneity of IFN-γ-licensed mesenchymal stromal cell immunosuppressive capacity on biomaterials.
Proceedings of the National Academy of Sciences of the United States of America
Kwee BJ,Lam J,Akue A,KuKuruga MA,Zhang K,Gu L,Sung KE
Tue Aug 31 00:00:00 UTC 2021
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
Proceedings of the National Academy of Sciences of the United States of America
O'Sullivan D,Stanczak MA,Villa M,Uhl FM,Corrado M,Klein Geltink RI,Sanin DE,Apostolova P,Rana N,Edwards-Hicks J,Grzes KM,Kabat AM,Kyle RL,Fabri M,Curtis JD,Buck MD,Patterson AE,Regina A,Field CS,Baixauli F,Puleston DJ,Pearce EJ,Zeiser R,Pearce EL
Tue Jun 22 00:00:00 UTC 2021
Dynamic chromatin regulatory landscape of human CAR T cell exhaustion.
Proceedings of the National Academy of Sciences of the United States of America
Gennert DG,Lynn RC,Granja JM,Weber EW,Mumbach MR,Zhao Y,Duren Z,Sotillo E,Greenleaf WJ,Wong WH,Satpathy AT,Mackall CL,Chang HY
Tue Jul 27 00:00:00 UTC 2021
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.
Experimental & molecular medicine
Du F,Qi X,Zhang A,Sui F,Wang X,Proud CG,Lin C,Fan X,Li J
Wed Sep 01 00:00:00 UTC 2021
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.
Cancer immunology research
Liu SQ,Grantham A,Landry C,Granda B,Chopra R,Chakravarthy S,Deutsch S,Vogel M,Russo K,Seiss K,Tschantz WR,Rejtar T,Ruddy DA,Hu T,Aardalen K,Wagner JP,Dranoff G,D'Alessio JA
200-02 was used in In vitro experiments to reveal multiple mechanisms that can be targeted to enhance the clinical potential of current and future T-cell-engaging CD3-bispecific antibody therapies.
Fri Jan 01 00:00:00 UTC 2021
Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
Oncogene
Cen B,Wei J,Wang D,Xiong Y,Shay JW,DuBois RN
Fri Oct 01 00:00:00 UTC 2021
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Mucosal immunology
Qiu J,Zhang J,Ji Y,Sun H,Gu Z,Sun Q,Bai M,Gong J,Tang J,Zhang Y,Li S,Shao Z,Li J,Sheng H,Shen L,Qiu J
Mon Nov 01 00:00:00 UTC 2021
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection.
Mucosal immunology
Egedal JH,Xie G,Packard TA,Laustsen A,Neidleman J,Georgiou K,Pillai SK,Greene WC,Jakobsen MR,Roan NR
Wed Sep 01 00:00:00 UTC 2021
Large-Scale Identification of T-Cell Epitopes Derived From Severe Acute Respiratory Syndrome Coronavirus 2 for the Development of Peptide Vaccines Against Coronavirus Disease 2019.
The Journal of infectious diseases
Ma Y,Liu F,Lin T,Chen L,Jiang A,Tian G,Nielsen M,Wang M
Fri Sep 17 00:00:00 UTC 2021
Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells.
Blood advances
Parri E,Kuusanmäki H,Bulanova D,Mustjoki S,Wennerberg K
Tue Apr 13 00:00:00 UTC 2021
Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
International journal of cancer
Herda S,Heimann A,Obermayer B,Ciraolo E,Althoff S,Ruß J,Grunert C,Busse A,Bullinger L,Pezzutto A,Blankenstein T,Beule D,Na IK
Tue Jun 15 00:00:00 UTC 2021
Mutant B2M-HLA-E and B2M-HLA-G fusion proteins protects universal chimeric antigen receptor-modified T cells from allogeneic NK cell-mediated lysis.
European journal of immunology
Guo Y,Xu B,Wu Z,Bo J,Tong C,Chen D,Wang J,Wang H,Wang Y,Han W
Fri Oct 01 00:00:00 UTC 2021
Human CXCR5+ PD-1+ CD8 T cells in healthy individuals and patients with hematologic malignancies.
European journal of immunology
Hofland T,Martens AWJ,van Bruggen JAC,de Boer R,Schetters S,Remmerswaal EBM,Bemelman FJ,Levin MD,Bins AD,Eldering E,Kater AP,Tonino SH
Mon Mar 01 00:00:00 UTC 2021
PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma.
Oncogenesis
Wang MY,Qi B,Wang F,Lin ZR,Li MY,Yin WJ,Zhu YY,He L,Yu Y,Yang F,Liu JQ,Chen DP
200-02 was used in In Vitro experiments to investigate the role of CD276 in cancer oncogenes signaling, specifically as regulated by PBK.
Tue Jan 05 00:00:00 UTC 2021
Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.
Cancer science
Mori T,Tanaka H,Suzuki S,Deguchi S,Yamakoshi Y,Yoshii M,Miki Y,Tamura T,Toyokawa T,Lee S,Muguruma K,Wanibuchi H,Ohira M
200-02 was used in Sample Preparation (FC/FACS) to perform immunohistochemical and immunofluorescence staining to detect the presence of CD103+ T cells and assess the association between CD103+ T cells and tertiary lymphoid structures (TLSs) in the tumor immune microenvironment in gastric cancer (GC).
Sat May 01 00:00:00 UTC 2021
Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection.
Cytotherapy
Soni M,Migliori E,Assal A,Chan HT,Ciubotariu R,Pan JB,Cicero K,Pereira M,Mapara MY,Muranski P
Mon Nov 01 00:00:00 UTC 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
200-02 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Apr 03 00:00:00 UTC 2024
Attenuation of canonical NF-κB signaling maintains function and stability of human Treg.
The FEBS journal
Ziegler LS,Gerner MC,Schmidt RLJ,Trapin D,Steinberger P,Pickl WF,Sillaber C,Egger G,Schwarzinger I,Schmetterer KG
Fri Jan 01 00:00:00 UTC 2021
TCR Affinity Controls the Dynamics but Not the Functional Specification of the Antimycobacterial CD4+ T Cell Response.
Journal of immunology (Baltimore, Md. : 1950)
Bhattacharyya ND,Counoupas C,Daniel L,Zhang G,Cook SJ,Cootes TA,Stifter SA,Bowen DG,Triccas JA,Bertolino P,Britton WJ,Feng CG
Tue Jun 15 00:00:00 UTC 2021
Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Lee YJ,Park EH,Park JW,Jung KC,Lee EB
Thu Jul 15 00:00:00 UTC 2021
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
O'Connell P,Hyslop S,Blake MK,Godbehere S,Amalfitano A,Aldhamen YA
Fri Jan 01 00:00:00 UTC 2021
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation.
Journal of immunology (Baltimore, Md. : 1950)
Price MJ,Scharer CD,Kania AK,Randall TD,Boss JM
Thu Apr 01 00:00:00 UTC 2021
Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease.
Journal of immunology (Baltimore, Md. : 1950)
Keir ME,Fuh F,Ichikawa R,Acres M,Hackney JA,Hulme G,Carey CD,Palmer J,Jones CJ,Long AK,Jiang J,Klabunde S,Mansfield JC,Looney CM,Faubion WA,Filby A,Kirby JA,McBride J,Lamb CA
Mon Nov 01 00:00:00 UTC 2021
Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.
Journal of immunology (Baltimore, Md. : 1950)
Perry N,Wasko K,Cheng J,Tabbaa D,Marco E,Giannoukos G,Albright CF,Borges CM
Fri Jan 15 00:00:00 UTC 2021
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI
Thu Apr 01 00:00:00 UTC 2021
Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option.
Journal of cellular and molecular medicine
Naseri M,Zöller M,Hadjati J,Ghods R,Ranaei Pirmardan E,Kiani J,Eini L,Bozorgmehr M,Madjd Z
Thu Apr 01 00:00:00 UTC 2021
SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia.
Stem cells international
Chen Z,Zhou S,Li J,Li H,Huang C,Guo Q,Zhang T,Yang B,Tu C,Guo C
Fri Nov 19 00:00:00 UTC 2021
Gastric Cancer Mesenchymal Stem Cells Inhibit NK Cell Function through mTOR Signalling to Promote Tumour Growth.
Stem cells international
Guo S,Huang C,Han F,Chen B,Ding Y,Zhao Y,Chen Z,Wen S,Wang M,Shen B,Zhu W
Tue Jul 27 00:00:00 UTC 2021
GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.
Translational oncology
Sujjitjoon J,Sayour E,Tsao ST,Uiprasertkul M,Sanpakit K,Buaboonnam J,Yenchitsomanus PT,Atchaneeyasakul LO,Chang LJ
Mon Feb 01 00:00:00 UTC 2021
Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation.
Journal of immunology research
Yan W,Zhao YS,Xie K,Xing Y,Xu F
Wed Dec 15 00:00:00 UTC 2021
Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization.
American journal of translational research
Xun X,Zhang C,Wang S,Hu S,Xiang X,Cheng Q,Li Z,Wang Y,Zhu J
200-02 was used in In vitro experiments to investigate the COX-2-dependent immune regulation pathway.
Tue Jun 22 00:00:00 UTC 2021
Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.
Cell adhesion & migration
Roncato F,Regev O,Yadav SK,Alon R
200-02 was used in In vitro experiments on human lymphocytes.
Wed Dec 01 00:00:00 UTC 2021
The S Protein of SARS-CoV-2 Injures Cardiomyocytes Indirectly through the Release of Cytokines Instead of Direct Action.
Acta Cardiologica Sinica
Chang WT,Lin YW,Chen ZC,Liu PY
Mon Nov 01 00:00:00 UTC 2021
Numerical optimization of microfluidic vortex shedding for genome editing T cells with Cas9.
Scientific reports
Jarrell JA,Sytsma BJ,Wilson LH,Pan FL,Lau KHWJ,Kirby GTS,Lievano AA,Pawell RS
Thu Jun 03 00:00:00 UTC 2021
Rapid, label-free classification of tumor-reactive T cell killing with quantitative phase microscopy and machine learning.
Scientific reports
Kim DNH,Lim AA,Teitell MA
Thu Sep 30 00:00:00 UTC 2021
PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.
Frontiers in immunology
Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y
200-02 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.
Mon Oct 25 00:00:00 UTC 2021
Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.
iScience
Portillo AL,Hogg R,Poznanski SM,Rojas EA,Cashell NJ,Hammill JA,Chew MV,Shenouda MM,Ritchie TM,Cao QT,Hirota JA,Dhesy-Thind S,Bramson JL,Ashkar AA
Fri Jun 25 00:00:00 UTC 2021
NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.
Cell reports
Cazzetta V,Bruni E,Terzoli S,Carenza C,Franzese S,Piazza R,Marzano P,Donadon M,Torzilli G,Cimino M,Simonelli M,Bello L,Villa A,Tan L,Ravens S,Prinz I,Supino D,Colombo FS,Lugli E,Marcenaro E,Vivier E,Della Bella S,Mikulak J,Mavilio D
Tue Oct 19 00:00:00 UTC 2021
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.
Cell reports
Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B
Tue Oct 12 00:00:00 UTC 2021
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Nature communications
Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M
Fri May 21 00:00:00 UTC 2021
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.
FEBS open bio
Zhang H,Liu P,Zhang Y,Han L,Hu Z,Cai Z,Cai J
Mon Mar 01 00:00:00 UTC 2021
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.
Frontiers in immunology
Wurzer H,Filali L,Hoffmann C,Krecke M,Biolato AM,Mastio J,De Wilde S,François JH,Largeot A,Berchem G,Paggetti J,Moussay E,Thomas C
200-02 was used in Cell Culture to study the role of the chronic lymphocytic leukemia (CLL) cell actin cytoskeleton during natural killer (NK) cell attack to show CLL cells can undergo fast actin cytoskeleton remodeling which is characterized by a NK cell contact-induced accumulation of actin filaments at the immunological synapse (IS).
Mon Jun 28 00:00:00 UTC 2021
Soluble trivalent engagers redirect cytolytic T cell activity toward tumor endothelial marker 1.
Cell reports. Medicine
Fierle JK,Brioschi M,de Tiani M,Wetterwald L,Atsaves V,Abram-Saliba J,Petrova TV,Coukos G,Dunn SM
Tue Aug 17 00:00:00 UTC 2021
Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes.
Communications biology
Panea C,Zhang R,VanValkenburgh J,Ni M,Adler C,Wei Y,Ochoa F,Schmahl J,Tang Y,Siao CJ,Poueymirou W,Espert J,Lim WK,Atwal GS,Murphy AJ,Sleeman MA,Hovhannisyan Z,Haxhinasto S
Mon Jul 26 00:00:00 UTC 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
Tue Nov 23 00:00:00 UTC 2021
Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development.
Cell reports
Zhang H,Dai D,Hu Q,Yang F,Xue Y,Li F,Shen N,Zhang M,Huang C
Tue May 11 00:00:00 UTC 2021
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Cell death & disease
Li Y,Zhang N,Ma C,Xu W,Jin G,Zheng Y,Zhang L,Liu B,Gao C,Liu S
Tue Oct 26 00:00:00 UTC 2021
Different endurance exercises modulate NK cell cytotoxic and inhibiting receptors.
European journal of applied physiology
Pal A,Schneider J,Schlüter K,Steindorf K,Wiskemann J,Rosenberger F,Zimmer P
200-02 was used in Cell Culture to investigate whether AhR and IDO levels as well as activating (NKG2D) and inhibiting (KIR2DL1) NK cell receptors are influenced by acute exercise and different chronic endurance exercise programs.
Wed Dec 01 00:00:00 UTC 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
200-02 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 UTC 2021
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.
Nature communications
Giuffrida L,Sek K,Henderson MA,Lai J,Chen AXY,Meyran D,Todd KL,Petley EV,Mardiana S,Mølck C,Stewart GD,Solomon BJ,Parish IA,Neeson PJ,Harrison SJ,Kats LM,House IG,Darcy PK,Beavis PA
Fri May 28 00:00:00 UTC 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 UTC 2021
Integrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders.
NPJ systems biology and applications
Puniya BL,Amin R,Lichter B,Moore R,Ciurej A,Bennett SJ,Shah AR,Barberis M,Helikar T
Fri Jan 22 00:00:00 UTC 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 UTC 2021
Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression.
Blood cancer journal
Quijada-Álamo M,Hernández-Sánchez M,Rodríguez-Vicente AE,Pérez-Carretero C,Rodríguez-Sánchez A,Martín-Izquierdo M,Alonso-Pérez V,García-Tuñón I,Bastida JM,Vidal-Manceñido MJ,Galende J,Aguilar C,Queizán JA,González-Gascón Y Marín I,Hernández-Rivas JÁ,Benito R,Ordóñez JL,Hernández-Rivas JM
Fri Jul 09 00:00:00 UTC 2021
HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.
Cell reports
Nesterenko PA,McLaughlin J,Tsai BL,Burton Sojo G,Cheng D,Zhao D,Mao Z,Bangayan NJ,Obusan MB,Su Y,Ng RH,Chour W,Xie J,Li YR,Lee D,Noguchi M,Carmona C,Phillips JW,Kim JT,Yang L,Heath JR,Boutros PC,Witte ON
Tue Dec 28 00:00:00 UTC 2021
An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.
Cell chemical biology
Carbonneau S,Sharma S,Peng L,Rajan V,Hainzl D,Henault M,Yang C,Hale J,Shulok J,Tallarico J,Porter J,Brogdon JL,Dranoff G,Bradner JE,Hild M,Guimaraes CP
Thu Jun 17 00:00:00 UTC 2021
Quantitative modeling predicts competitive advantages of a next generation anti-NKG2A monoclonal antibody over monalizumab for the treatment of cancer.
CPT: pharmacometrics & systems pharmacology
Spinosa P,Musial-Siwek M,Presler M,Betts A,Rosentrater E,Villali J,Wille L,Zhao Y,McCaughtry T,Subramanian K,Liu H
Mon Mar 01 00:00:00 UTC 2021
SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.
Blood cancer journal
Maiti GP,Sinha S,Mahmud H,Boysen J,Mendez MT,Vesely SK,Holter-Chakrabarty J,Kay NE,Ghosh AK
Mon May 17 00:00:00 UTC 2021
An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip.
Scientific reports
Subedi N,Van Eyndhoven LC,Hokke AM,Houben L,Van Turnhout MC,Bouten CVC,Eyer K,Tel J
Tue Aug 24 00:00:00 UTC 2021
An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip.
Scientific reports
Subedi N,Van Eyndhoven LC,Hokke AM,Houben L,Van Turnhout MC,Bouten CVC,Eyer K,Tel J
Tue Aug 24 00:00:00 UTC 2021
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.
STAR protocols
Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ
200-02 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.
Fri Dec 17 00:00:00 UTC 2021
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.
STAR protocols
Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ
200-02 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.
Fri Dec 17 00:00:00 UTC 2021
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.
Scientific reports
Sivapalan R,Liu J,Chakraborty K,Arthofer E,Choudhry M,Barie PS,Barouch DH,Henley T
Tue Jul 27 00:00:00 UTC 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Fri Jun 25 00:00:00 UTC 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 UTC 2021
Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury.
NPJ precision oncology
Williamson LM,Rive CM,Di Francesco D,Titmuss E,Chun HE,Brown SD,Milne K,Pleasance E,Lee AF,Yip S,Rosenbaum DG,Hasselblatt M,Johann PD,Kool M,Harvey M,Dix D,Renouf DJ,Holt RA,Nelson BH,Hirst M,Jones SJM,Laskin J,Rassekh SR,Deyell RJ,Marra MA
Mon Dec 20 00:00:00 UTC 2021
Control of the activity of CAR-T cells within tumours via focused ultrasound.
Nature biomedical engineering
Wu Y,Liu Y,Huang Z,Wang X,Jin Z,Li J,Limsakul P,Zhu L,Allen M,Pan Y,Bussell R,Jacobson A,Liu T,Chien S,Wang Y
Mon Nov 01 00:00:00 UTC 2021
P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.
Nature communications
Rousso-Noori L,Mastandrea I,Talmor S,Waks T,Globerson Levin A,Haugas M,Teesalu T,Alvarez-Vallina L,Eshhar Z,Friedmann-Morvinski D
Mon Jun 14 00:00:00 UTC 2021
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.
bioRxiv : the preprint server for biology
Yu B,Qi Y,Li R,Shi Q,Satpathy A,Chang HY
Tue Jan 05 00:00:00 UTC 2021
Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder.
eLife
Wu B,Rice L,Shrimpton J,Lawless D,Walker K,Carter C,McKeown L,Anwar R,Doody GM,Srikanth S,Gwack Y,Savic S
200-02 was used in Cell Culture to identify variants in CRACR2A that led to late-stage combined immunodeficiency characterized by loss of function in T cells.
Wed Dec 15 00:00:00 UTC 2021
MICA-G129R: A bifunctional fusion protein increases PRLR-positive breast cancer cell death in co-culture with natural killer cells.
PloS one
Ding H,Buzzard GW,Huang S,Sehorn MG,Marcus RK,Wei Y
200-02 was used in Cell Culture to investigate prolactin receptor in breast cancer growth.
Fri Nov 12 00:00:00 UTC 2021
Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function.
International journal of molecular sciences
Fante MA,Decking SM,Bruss C,Schreml S,Siska PJ,Kreutz M,Renner K
200-02 was used in Cell Culture to demonstrate a beneficial effect of heat-inactivation of human sera for T cell experiments but indicate that beside complement regulators and immune complexes other components might be relevant.
Fri Mar 05 00:00:00 UTC 2021
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Nature communications
Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A
Thu Nov 25 00:00:00 UTC 2021
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells.
Cell reports
Wu B,Woo JS,Vila P,Jew M,Leung J,Sun Z,Srikanth S,Gwack Y
Tue Aug 24 00:00:00 UTC 2021
Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity.
Scientific reports
Ottolenghi A,Bolel P,Sarkar R,Greenshpan Y,Iraqi M,Ghosh S,Bhattacharya B,Taylor ZV,Kundu K,Radinsky O,Gazit R,Stepensky D,Apte RN,Voronov E,Porgador A
Wed Apr 07 00:00:00 UTC 2021
Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity.
Cell reports
Vono M,Huttner A,Lemeille S,Martinez-Murillo P,Meyer B,Baggio S,Sharma S,Thiriard A,Marchant A,Godeke GJ,Reusken C,Alvarez C,Perez-Rodriguez F,Eckerle I,Kaiser L,Loevy N,Eberhardt CS,Blanchard-Rohner G,Siegrist CA,Didierlaurent AM
200-02 was used in Cell Culture to reveal that better early control of inflammation as observed in children may be key for rapidly controlling infection and limiting the disease course.
Tue Oct 05 00:00:00 UTC 2021
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer.
Nature communications
Huang Y,Zhang HL,Li ZL,Du T,Chen YH,Wang Y,Ni HH,Zhang KM,Mai J,Hu BX,Huang JH,Zhou LH,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
Tue May 11 00:00:00 UTC 2021
MAIT cells regulate NK cell-mediated tumor immunity.
Nature communications
Petley EV,Koay HF,Henderson MA,Sek K,Todd KL,Keam SP,Lai J,House IG,Li J,Zethoven M,Chen AXY,Oliver AJ,Michie J,Freeman AJ,Giuffrida L,Chan JD,Pizzolla A,Mak JYW,McCulloch TR,Souza-Fonseca-Guimaraes F,Kearney CJ,Millen R,Ramsay RG,Huntington ND,McCluskey J,Oliaro J,Fairlie DP,Neeson PJ,Godfrey DI,Beavis PA,Darcy PK
Fri Aug 06 00:00:00 UTC 2021
High-resolution positron emission microscopy of patient-derived tumor organoids.
Nature communications
Khan S,Shin JH,Ferri V,Cheng N,Noel JE,Kuo C,Sunwoo JB,Pratx G
Thu Oct 07 00:00:00 UTC 2021
Live imaging of chromatin distribution reveals novel principles of nuclear architecture and chromatin compartmentalization.
Science advances
Amiad-Pavlov D,Lorber D,Bajpai G,Reuveny A,Roncato F,Alon R,Safran S,Volk T
200-02 was used in Cell Culture to reveal a novel mode of mesoscale organization of peripheral chromatin sensitive to lamina composition, which is evolutionary conserved.
Tue Jun 01 00:00:00 UTC 2021
Pseurotin D Inhibits the Activation of Human Lymphocytes.
International journal of molecular sciences
Rubanova D,Dadova P,Vasicek O,Kubala L
200-02 was used in Cell Culture to perform complex characterization of the effects of pseurotin D on human lymphocyte activation to understand the potential of pseurotin to modulate immune response in humans.
Tue Feb 16 00:00:00 UTC 2021
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
Molecular therapy. Methods & clinical development
Haeseleer F,Fukazawa Y,Park H,Varco-Merth B,Rust BJ,Smedley JV,Eichholz K,Peterson CW,Mason R,Kiem HP,Roederer M,Picker LJ,Okoye AA,Corey L
Fri Sep 10 00:00:00 UTC 2021
Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment.
Cell death & disease
Xu R,Wu M,Liu S,Shang W,Li R,Xu J,Huang L,Wang F
Thu Jan 07 00:00:00 UTC 2021
Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications.
STAR protocols
Kumar A,Lee SJ,Liu Q,Chan AKN,Pokharel SP,Yu J,Chen CW,Swaminathan S
200-02 was used in Cell Culture to show that our CRISPR-engineered NK-92 cell platforms can be modified for research and off-the-shelf therapeutic applications.
Fri Dec 17 00:00:00 UTC 2021
In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM
Thu Jul 01 00:00:00 UTC 2021
Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors.
Science advances
Hörner M,Jerez-Longres C,Hudek A,Hook S,Yousefi OS,Schamel WWA,Hörner C,Zurbriggen MD,Ye H,Wagner HJ,Weber W
200-02 was used in Cell Culture to engineer an adeno-associated viral (AAV) vector system that transfers genetic information into native target cells upon illumination with cell-compatible red light.
Tue Jun 01 00:00:00 UTC 2021
A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
de Weerdt I,Lameris R,Ruben JM,de Boer R,Kloosterman J,King LA,Levin MD,Parren PWHI,de Gruijl TD,Kater AP,van der Vliet HJ
200-02 was used in Cell Culture to investigate T cell immunotherapies for B cell malignancies.
Mon Mar 15 00:00:00 UTC 2021
A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
Cell reports
Nakagawa T,Jörg DJ,Watanabe H,Mizuno S,Han S,Ikeda T,Omatsu Y,Nishimura K,Fujita M,Takahashi S,Kondoh G,Simons BD,Yoshida S,Nagasawa T
Tue Oct 19 00:00:00 UTC 2021
Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19.
Journal of nanobiotechnology
Zhu T,Xiao Y,Meng X,Tang L,Li B,Zhao Z,Tan Q,Shan H,Liu L,Huang X
Thu Nov 25 00:00:00 UTC 2021
Activated Lymphocytes and Increased Risk of Dermatologic Adverse Events during Sorafenib Therapy for Hepatocellular Carcinoma.
Cancers
Corominas J,Sapena V,Sanduzzi-Zamparelli M,Millán C,Samper E,Llarch N,Iserte G,Torres F,Da Fonseca LG,Muñoz-Martínez S,Forner A,Bruix J,Boix L,Reig M
200-02 was used in In vitro experiments to investigate immune implication accompanying better prognosis and dermatological adverse effects of sorafenib treatment of advanced hepatocellular carcinoma.
Sat Jan 23 00:00:00 UTC 2021
TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1.
Cell death & disease
Lake CM,Voss K,Bauman BM,Pohida K,Jiang T,Dveksler G,Snow AL
Wed Apr 14 00:00:00 UTC 2021
A Novel Peptide-MHC Targeted Chimeric Antigen Receptor T Cell Forms a T Cell-like Immune Synapse.
Biomedicines
Wang SS,Luong K,Gracey FM,Jabar S,McColl B,Cross RS,Jenkins MR
200-02 was used in Cell Culture to investigate the effects of Chimeric Antigen Receptor T cell expression to target peptide-MHC tumour.
Fri Dec 10 00:00:00 UTC 2021
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
Nature communications
Fischer DS,Ansari M,Wagner KI,Jarosch S,Huang Y,Mayr CH,Strunz M,Lang NJ,D'Ippolito E,Hammel M,Mateyka L,Weber S,Wolff LS,Witter K,Fernandez IE,Leuschner G,Milger K,Frankenberger M,Nowak L,Heinig-Menhard K,Koch I,Stoleriu MG,Hilgendorff A,Behr J,Pichlmair A,Schubert B,Theis FJ,Busch DH,Schiller HB,Schober K
Mon Jul 26 00:00:00 UTC 2021
On-Chip Biogenesis of Circulating NK Cell-Derived Exosomes in Non-Small Cell Lung Cancer Exhibits Antitumoral Activity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kang YT,Niu Z,Hadlock T,Purcell E,Lo TW,Zeinali M,Owen S,Keshamouni VG,Reddy R,Ramnath N,Nagrath S
Mon Mar 01 00:00:00 UTC 2021
miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells.
Cancers
Qin Z,Hu H,Sun W,Chen L,Jin S,Xu Q,Liu Y,Yu L,Zeng S
200-02 was used in Cell Culture to indicate that miR-224-5p was significantly upregulated in urinary EVs of RCC patients compared to healthy volunteers.
Thu Feb 04 00:00:00 UTC 2021
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses.
Science immunology
Agerer B,Koblischke M,Gudipati V,Montaño-Gutierrez LF,Smyth M,Popa A,Genger JW,Endler L,Florian DM,Mühlgrabner V,Graninger M,Aberle SW,Husa AM,Shaw LE,Lercher A,Gattinger P,Torralba-Gombau R,Trapin D,Penz T,Barreca D,Fae I,Wenda S,Traugott M,Walder G,Pickl WF,Thiel V,Allerberger F,Stockinger H,Puchhammer-Stöckl E,Weninger W,Fischer G,Hoepler W,Pawelka E,Zoufaly A,Valenta R,Bock C,Paster W,Geyeregger R,Farlik M,Halbritter F,Huppa JB,Aberle JH,Bergthaler A
Thu Mar 04 00:00:00 UTC 2021
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies.
Cell reports
Brohl AS,Sindiri S,Wei JS,Milewski D,Chou HC,Song YK,Wen X,Kumar J,Reardon HV,Mudunuri US,Collins JR,Nagaraj S,Gangalapudi V,Tyagi M,Zhu YJ,Masih KE,Yohe ME,Shern JF,Qi Y,Guha U,Catchpoole D,Orentas RJ,Kuznetsov IB,Llosa NJ,Ligon JA,Turpin BK,Leino DG,Iwata S,Andrulis IL,Wunder JS,Toledo SRC,Meltzer PS,Lau C,Teicher BA,Magnan H,Ladanyi M,Khan J
200-02 was used in In vitro experiments to provide a critical framework for immune targeting of extracranial solid tumors using parallel immuno-transcriptomic and -peptidomic approaches.
Tue Nov 23 00:00:00 UTC 2021
Next Generation Sequencing-Based Identification of T-Cell Receptors for Immunotherapy Against Hepatocellular Carcinoma.
Hepatology communications
Ma Y,Ou J,Lin T,Chen L,Chen J,Wang M
Tue Jun 01 00:00:00 UTC 2021
Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow.
Cell reports
Magod P,Mastandrea I,Rousso-Noori L,Agemy L,Shapira G,Shomron N,Friedmann-Morvinski D
Tue Aug 03 00:00:00 UTC 2021
Morphological profiling of human T and NK lymphocytes by high-content cell imaging.
Cell reports
German Y,Vulliard L,Kamnev A,Pfajfer L,Huemer J,Mautner AK,Rubio A,Kalinichenko A,Boztug K,Ferrand A,Menche J,Dupré L
Tue Jul 06 00:00:00 UTC 2021
A resource of high-quality and versatile nanobodies for drug delivery.
iScience
Shen Z,Xiang Y,Vergara S,Chen A,Xiao Z,Santiago U,Jin C,Sang Z,Luo J,Chen K,Schneidman-Duhovny D,Camacho C,Calero G,Hu B,Shi Y
Fri Sep 24 00:00:00 UTC 2021
A resource of high-quality and versatile nanobodies for drug delivery.
iScience
Shen Z,Xiang Y,Vergara S,Chen A,Xiao Z,Santiago U,Jin C,Sang Z,Luo J,Chen K,Schneidman-Duhovny D,Camacho C,Calero G,Hu B,Shi Y
Fri Sep 24 00:00:00 UTC 2021
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.
Nature communications
Schmidt NM,Wing PAC,Diniz MO,Pallett LJ,Swadling L,Harris JM,Burton AR,Jeffery-Smith A,Zakeri N,Amin OE,Kucykowicz S,Heemskerk MH,Davidson B,Meyer T,Grove J,Stauss HJ,Pineda-Torra I,Jolly C,Jury EC,McKeating JA,Maini MK
Fri May 14 00:00:00 UTC 2021
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.
Cell reports. Medicine
Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH
Tue Aug 17 00:00:00 UTC 2021
Sample preparation strategies for efficient correlation of 3D SIM and soft X-ray tomography data at cryogenic temperatures.
Nature protocols
Okolo CA,Kounatidis I,Groen J,Nahas KL,Balint S,Fish TM,Koronfel MA,Cortajarena AL,Dobbie IM,Pereiro E,Harkiolaki M
200-02 was used in Cell Culture to present here sample preparation strategies and a direct comparison of different working fiducialization regimes that facilitate 3D correlation of cryo-structured illumination microscopy and cryo-soft X-ray tomography.
Tue Jun 01 00:00:00 UTC 2021
Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells.
Scientific reports
Ding M,Malhotra R,Ottosson T,Lundqvist M,Mebrahtu A,Brengdahl J,Gehrmann U,Bäck E,Ross-Thriepland D,Isaksson I,Magnusson B,Sachsenmeier KF,Tegel H,Hober S,Uhlén M,Mayr LM,Davies R,Rockberg J,Schiavone LH
Wed Aug 18 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment.
Cell death discovery
Yu Y,Liang Y,Li D,Wang L,Liang Z,Chen Y,Ma G,Wu H,Jiao W,Niu H
Mon Jan 18 00:00:00 UTC 2021
Co-expression of IL-7 and PH20 promote anti-GPC3 CAR-T tumour suppressor activity in vivo and in vitro.
Liver international : official journal of the International Association for the Study of the Liver
Xiong X,Xi J,Liu Q,Wang C,Jiang Z,Yue SY,Shi L,Rong Y
200-02 was used in In vitro experiments to find (G3CAR-7 × 20) exhibited better proliferation in vivo and in vitro than G3CAR, reduced the level of apoptosis after stimulation by tumour cells, and maintained the memory phenotype of CAR-T cells.
Sat May 01 00:00:00 UTC 2021
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control.
Nature biomedical engineering
Miller IC,Zamat A,Sun LK,Phuengkham H,Harris AM,Gamboa L,Yang J,Murad JP,Priceman SJ,Kwong GA
Mon Nov 01 00:00:00 UTC 2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons
Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD
200-02 was used in Cell Culture to investigate correlations between cytokine expression and mortality.
Wed Jul 21 00:00:00 UTC 2021
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Frontiers in immunology
Luff DH,Wojdyla K,Oxley D,Chessa T,Hudson K,Hawkins PT,Stephens LR,Barry ST,Okkenhaug K
200-02 was used in Cell activation to show how the PI3Kδ interactome is remodeled as CD4+ T cells differentiate from naïve T cells to activated T cell blasts.
Wed Sep 15 00:00:00 UTC 2021
A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain.
Nature communications
Seidel E,Dassa L,Kahlon S,Tirosh B,Halenius A,Seidel Malkinson T,Mandelboim O
Tue Apr 06 00:00:00 UTC 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
HIV-1 Vpu Promotes Phagocytosis of Infected CD4+ T Cells by Macrophages through Downregulation of CD47.
mBio
Cong L,Sugden SM,Leclair P,Lim CJ,Pham TNQ,Cohen ÉA
200-02 was used in Cell Culture to investigate the effects of HIV-1 on CD47 expression in macrophages.
Tue Aug 31 00:00:00 UTC 2021
Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.
Vaccines
Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y
200-02 was used in In vitro experiments to investigate treatment for esophageal squamous cell carcinoma.
Fri Oct 01 00:00:00 UTC 2021
Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus.
Frontiers in immunology
Kato H,Perl A
200-02 was used in Cell Culture to study the effects of IL-2 on pro-inflammatory cytokine production by CD4+ and CD8+ T cells in parallel with Treg development following CD3/CD28 co-stimulation.
Tue Sep 21 00:00:00 UTC 2021
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
Nature communications
Liu Y,Debo B,Li M,Shi Z,Sheng W,Shi Y
Wed Nov 24 00:00:00 UTC 2021
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
Nature communications
Liu Y,Debo B,Li M,Shi Z,Sheng W,Shi Y
Wed Nov 24 00:00:00 UTC 2021
SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.
Nature communications
Hou G,Harley ITW,Lu X,Zhou T,Xu N,Yao C,Qin Y,Ouyang Y,Ma J,Zhu X,Yu X,Xu H,Dai D,Ding H,Yin Z,Ye Z,Deng J,Zhou M,Tang Y,Namjou B,Guo Y,Weirauch MT,Kottyan LC,Harley JB,Shen N
Fri Jan 08 00:00:00 UTC 2021
3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity.
Communications biology
Gopal S,Kwon SJ,Ku B,Lee DW,Kim J,Dordick JS
Wed Jul 21 00:00:00 UTC 2021
Retracted: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
Morita K,He S,Nowak RP,Wang J,Zimmerman MW,Fu C,Durbin AD,Martel MW,Prutsch N,Gray NS,Fischer ES,Look AT
Thu Apr 30 00:00:00 UTC 2020
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Cell
Sekine T,Perez-Potti A,Rivera-Ballesteros O,Strålin K,Gorin JB,Olsson A,Llewellyn-Lacey S,Kamal H,Bogdanovic G,Muschiol S,Wullimann DJ,Kammann T,Emgård J,Parrot T,Folkesson E,Rooyackers O,Eriksson LI,Henter JI,Sönnerborg A,Allander T,Albert J,Nielsen M,Klingström J,Gredmark-Russ S,Björkström NK,Sandberg JK,Price DA,Ljunggren HG,Aleman S,Buggert M
Thu Oct 01 00:00:00 UTC 2020
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
Cell
Oh DY,Kwek SS,Raju SS,Li T,McCarthy E,Chow E,Aran D,Ilano A,Pai CS,Rancan C,Allaire K,Burra A,Sun Y,Spitzer MH,Mangul S,Porten S,Meng MV,Friedlander TW,Ye CJ,Fong L
Thu Jun 25 00:00:00 UTC 2020
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
Cell
Oh DY,Kwek SS,Raju SS,Li T,McCarthy E,Chow E,Aran D,Ilano A,Pai CS,Rancan C,Allaire K,Burra A,Sun Y,Spitzer MH,Mangul S,Porten S,Meng MV,Friedlander TW,Ye CJ,Fong L
Thu Jun 25 00:00:00 UTC 2020
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
Cell
Wang J,Xu Y,Chen Z,Liang J,Lin Z,Liang H,Xu Y,Wu Q,Guo X,Nie J,Lu B,Huang B,Xian H,Wang X,Wu Q,Zeng J,Chai C,Zhang M,Lin Y,Zhang L,Zhao S,Tong Y,Zeng L,Gu X,Chen ZG,Yi S,Zhang T,Delfouneso D,Zhang Y,Nutt SL,Lew AM,Lu L,Bai F,Xia H,Wen Z,Zhang Y
Wed Dec 23 00:00:00 UTC 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
Thu Mar 19 00:00:00 UTC 2020
CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.
Immunity
Braun M,Aguilera AR,Sundarrajan A,Corvino D,Stannard K,Krumeich S,Das I,Lima LG,Meza Guzman LG,Li K,Li R,Salim N,Jorge MV,Ham S,Kelly G,Vari F,Lepletier A,Raghavendra A,Pearson S,Madore J,Jacquelin S,Effern M,Quine B,Koufariotis LT,Casey M,Nakamura K,Seo EY,Hölzel M,Geyer M,Kristiansen G,Taheri T,Ahern E,Hughes BGM,Wilmott JS,Long GV,Scolyer RA,Batstone MD,Landsberg J,Dietrich D,Pop OT,Flatz L,Dougall WC,Veillette A,Nicholson SE,Möller A,Johnston RJ,Martinet L,Smyth MJ,Bald T
Tue Oct 13 00:00:00 UTC 2020
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.
Immunity
Kolev M,West EE,Kunz N,Chauss D,Moseman EA,Rahman J,Freiwald T,Balmer ML,Lötscher J,Dimeloe S,Rosser EC,Wedderburn LR,Mayer-Barber KD,Bohrer A,Lavender P,Cope A,Wang L,Kaplan MJ,Moutsopoulos NM,McGavern D,Holland SM,Hess C,Kazemian M,Afzali B,Kemper C
Tue Mar 17 00:00:00 UTC 2020
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Immunity
Ferretti AP,Kula T,Wang Y,Nguyen DMV,Weinheimer A,Dunlap GS,Xu Q,Nabilsi N,Perullo CR,Cristofaro AW,Whitton HJ,Virbasius A,Olivier KJ,Buckner LR,Alistar AT,Whitman ED,Bertino SA,Chattopadhyay S,MacBeath G
Tue Nov 17 00:00:00 UTC 2020
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Immunity
Ferretti AP,Kula T,Wang Y,Nguyen DMV,Weinheimer A,Dunlap GS,Xu Q,Nabilsi N,Perullo CR,Cristofaro AW,Whitton HJ,Virbasius A,Olivier KJ,Buckner LR,Alistar AT,Whitman ED,Bertino SA,Chattopadhyay S,MacBeath G
Tue Nov 17 00:00:00 UTC 2020
Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma.
Immunity
Effern M,Glodde N,Braun M,Liebing J,Boll HN,Yong M,Bawden E,Hinze D,van den Boorn-Konijnenberg D,Daoud M,Aymans P,Landsberg J,Smyth MJ,Flatz L,Tüting T,Bald T,Gebhardt T,Hölzel M
Tue Sep 15 00:00:00 UTC 2020
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Immunity
Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H
200-02 was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.
Tue Dec 15 00:00:00 UTC 2020
Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells.
Signal transduction and targeted therapy
Ni C,Fang QQ,Chen WZ,Jiang JX,Jiang Z,Ye J,Zhang T,Yang L,Meng FB,Xia WJ,Zhong M,Huang J
Wed Apr 29 00:00:00 UTC 2020
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
Cell metabolism
Hamaidi I,Zhang L,Kim N,Wang MH,Iclozan C,Fang B,Liu M,Koomen JM,Berglund AE,Yoder SJ,Yao J,Engelman RW,Creelan BC,Conejo-Garcia JR,Antonia SJ,Mulé JJ,Kim S
200-02 was used in In vitro experiments to unveil Sirt2 as an unexpected actionable target for reprogramming T cell metabolism to augment a broad spectrum of cancer immunotherapies.
Tue Sep 01 00:00:00 UTC 2020
Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma.
Blood
Gaydosik AM,Queen DS,Trager MH,Akilov OE,Geskin LJ,Fuschiotti P
Thu Oct 08 00:00:00 UTC 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 UTC 2020
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.
Blood
Rust BJ,Kean LS,Colonna L,Brandenstein KE,Poole NH,Obenza W,Enstrom MR,Maldini CR,Ellis GI,Fennessey CM,Huang ML,Keele BF,Jerome KR,Riley JL,Kiem HP,Peterson CW
Thu Oct 08 00:00:00 UTC 2020
TCR-pMHC bond conformation controls TCR ligand discrimination.
Cellular & molecular immunology
Sasmal DK,Feng W,Roy S,Leung P,He Y,Cai C,Cao G,Lian H,Qin J,Hui E,Schreiber H,Adams EJ,Huang J
Sun Mar 01 00:00:00 UTC 2020
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
The Journal of clinical investigation
Cao W,Fang F,Gould T,Li X,Kim C,Gustafson C,Lambert S,Weyand CM,Goronzy JJ
Wed Jul 01 00:00:00 UTC 2020
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells.
The Journal of clinical investigation
Yang Y,Neo SY,Chen Z,Cui W,Chen Y,Guo M,Wang Y,Xu H,Kurzay A,Alici E,Holmgren L,Haglund F,Wang K,Lundqvist A
Thu Oct 01 00:00:00 UTC 2020
Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.
The Journal of clinical investigation
Perez-Diez A,Wong CS,Liu X,Mystakelis H,Song J,Lu Y,Sheikh V,Bourgeois JS,Lisco A,Laidlaw E,Cudrici C,Zhu C,Li QZ,Freeman AF,Williamson PR,Anderson M,Roby G,Tsang JS,Siegel R,Sereti I
Thu Oct 01 00:00:00 UTC 2020
Autologous tumor cell vaccine induces antitumor T cell immune responses in patients with mantle cell lymphoma: A phase I/II trial.
The Journal of experimental medicine
Frank MJ,Khodadoust MS,Czerwinski DK,Haabeth OAW,Chu MP,Miklos DB,Advani RH,Alizadeh AA,Gupta NK,Maeda LS,Reddy SA,Laport GG,Meyer EH,Negrin RS,Rezvani AR,Weng WK,Sheehan K,Faham M,Okada A,Moore AH,Phillips DL,Wapnir IL,Brody JD,Levy R
Mon Sep 07 00:00:00 UTC 2020
Mechanosensing through YAP controls T cell activation and metabolism.
The Journal of experimental medicine
Meng KP,Majedi FS,Thauland TJ,Butte MJ
200-02 was used in Sample Preparation (FC/FACS) to study how the YAP mechanosensor is required for sensing the microenvironment mechanical changes which cause lymph nodes to become mechanically stiff as immune cells activate and proliferate within their encapsulated environments.
Mon Aug 03 00:00:00 UTC 2020
Resolving mechanisms of immune-mediated disease in primary CD4 T cells.
EMBO molecular medicine
Bourges C,Groff AF,Burren OS,Gerhardinger C,Mattioli K,Hutchinson A,Hu T,Anand T,Epping MW,Wallace C,Smith KG,Rinn JL,Lee JC
Fri May 08 00:00:00 UTC 2020
CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition.
Leukemia
Quijada-Álamo M,Hernández-Sánchez M,Alonso-Pérez V,Rodríguez-Vicente AE,García-Tuñón I,Martín-Izquierdo M,Hernández-Sánchez JM,Herrero AB,Bastida JM,San Segundo L,Gruber M,García JL,Yin S,Ten Hacken E,Benito R,Ordóñez JL,Wu CJ,Hernández-Rivas JM
Mon Jun 01 00:00:00 UTC 2020
Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America
Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ
Tue May 19 00:00:00 UTC 2020
Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Anton OM,Peterson ME,Hollander MJ,Dorward DW,Arora G,Traba J,Rajagopalan S,Snapp EL,Garcia KC,Waldmann TA,Long EO
Tue Jan 07 00:00:00 UTC 2020
Autoantibodies against central nervous system antigens in a subset of B cell-dominant multiple sclerosis patients.
Proceedings of the National Academy of Sciences of the United States of America
Kuerten S,Lanz TV,Lingampalli N,Lahey LJ,Kleinschnitz C,Mäurer M,Schroeter M,Braune S,Ziemssen T,Ho PP,Robinson WH,Steinman L
Tue Sep 01 00:00:00 UTC 2020
Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes.
Proceedings of the National Academy of Sciences of the United States of America
Affandi AJ,Grabowska J,Olesek K,Lopez Venegas M,Barbaria A,Rodríguez E,Mulder PPG,Pijffers HJ,Ambrosini M,Kalay H,O'Toole T,Zwart ES,Kazemier G,Nazmi K,Bikker FJ,Stöckl J,van den Eertwegh AJM,de Gruijl TD,Storm G,van Kooyk Y,den Haan JMM
Tue Nov 03 00:00:00 UTC 2020
Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins.
Proceedings of the National Academy of Sciences of the United States of America
Tanno H,Gould TM,McDaniel JR,Cao W,Tanno Y,Durrett RE,Park D,Cate SJ,Hildebrand WH,Dekker CL,Tian L,Weyand CM,Georgiou G,Goronzy JJ
Tue Jan 07 00:00:00 UTC 2020
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Proceedings of the National Academy of Sciences of the United States of America
Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR
Tue Mar 17 00:00:00 UTC 2020
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Proceedings of the National Academy of Sciences of the United States of America
Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR
Tue Mar 17 00:00:00 UTC 2020
Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells.
Cancer immunology research
Ferrari de Andrade L,Kumar S,Luoma AM,Ito Y,Alves da Silva PH,Pan D,Pyrdol JW,Yoon CH,Wucherpfennig KW
200-02 was used in Cell Culture to investigate if resistant tumours can be targeted by natural killer cells with sufficient activating signals.
Mon Jun 01 00:00:00 UTC 2020
Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells.
Cancer immunology research
Ferrari de Andrade L,Kumar S,Luoma AM,Ito Y,Alves da Silva PH,Pan D,Pyrdol JW,Yoon CH,Wucherpfennig KW
200-02 was used in Cell Culture to investigate if resistant tumours can be targeted by natural killer cells with sufficient activating signals.
Mon Jun 01 00:00:00 UTC 2020
Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells.
Cancer immunology research
Ferrari de Andrade L,Kumar S,Luoma AM,Ito Y,Alves da Silva PH,Pan D,Pyrdol JW,Yoon CH,Wucherpfennig KW
200-02 was used in Cell Culture to investigate if resistant tumours can be targeted by natural killer cells with sufficient activating signals.
Mon Jun 01 00:00:00 UTC 2020
High-efficient generation of VCAM-1+ mesenchymal stem cells with multidimensional superiorities in signatures and efficacy on aplastic anaemia mice.
Cell proliferation
Wei Y,Zhang L,Chi Y,Ren X,Gao Y,Song B,Li C,Han Z,Zhang L,Han Z
Sat Aug 01 00:00:00 UTC 2020
The septin cytoskeleton regulates natural killer cell lytic granule release.
The Journal of cell biology
Phatarpekar PV,Overlee BL,Leehan A,Wilton KM,Ham H,Billadeau DD
Mon Nov 02 00:00:00 UTC 2020
Chimeric antigen receptor-modified T-cell therapy for platelet-derived growth factor receptor α-positive rhabdomyosarcoma.
Cancer
Xiao W,Wang J,Wen X,Xu B,Que Y,Yu K,Xu L,Zhao J,Pan Q,Zhou P,Zhang X
Fri May 01 00:00:00 UTC 2020
Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype.
European journal of immunology
Povoleri GAM,Lalnunhlimi S,Steel KJA,Agrawal S,O'Byrne AM,Ridley M,Kordasti S,Frederiksen KS,Roberts CA,Taams LS
Sun Mar 01 00:00:00 UTC 2020
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors.
mAbs
Hatterer E,Chauchet X,Richard F,Barba L,Moine V,Chatel L,Broyer L,Pontini G,Bautzova T,Juan F,Calloud S,Bosson N,Charreton M,Masternak K,Buatois V,Shang L
200-02 was used in Cell Culture to show that MSLN targeted by bispecific antibodies (bsAbs)optimized ADCC activity by augmenting FcγR-IIIA activation and enhanced ADCP via a more efficient blockade of the CD47/SIRPα axis.
Fri Feb 12 00:00:00 UTC 2021
IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huang Y,Li D,Zhang PF,Liu M,Liang X,Yang X,Jiang L,Zhang LF,Zhou WL,Su JH,Gong YL,Gou HF,Wei YQ,Wang W
Wed Jan 01 00:00:00 UTC 2020
The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gerner MC,Ziegler LS,Schmidt RLJ,Krenn M,Zimprich F,Uyanik-Ünal K,Konstantopoulou V,Derdak S,Del Favero G,Schwarzinger I,Boztug K,Schmetterer KG
Mon Jun 01 00:00:00 UTC 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
Wed Jan 01 00:00:00 UTC 2020
Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shen T,Huang Z,Shi C,Pu X,Xu X,Wu Z,Ding G,Cao L
Mon Jun 01 00:00:00 UTC 2020
Enhancement of the antitumor effect of HER2-directed CAR-T cells through blocking epithelial-mesenchymal transition in tumor cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang PF,Huang Y,Liang X,Li D,Jiang L,Yang X,Zhu M,Gou HF,Gong YL,Wei YQ,Li Q,Wang W
Sat Aug 01 00:00:00 UTC 2020
Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance.
Journal of immunology (Baltimore, Md. : 1950)
Liu GY,Deng XH,Li X,Cao YJ,Xing YF,Zhou P,Lei AH,Yang Q,Deng K,Zhang H,Zhou J
Wed Jul 01 00:00:00 UTC 2020
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D
Mon Jun 01 00:00:00 UTC 2020
A Cross-Species Reactive TIGIT-Blocking Antibody Fc Dependently Confers Potent Antitumor Effects.
Journal of immunology (Baltimore, Md. : 1950)
Yang F,Zhao L,Wei Z,Yang Y,Liu J,Li Y,Tian X,Liu X,Lü X,Sui J
Thu Oct 15 00:00:00 UTC 2020
Cord Blood Low-Density Granulocytes Correspond to an Immature Granulocytic Subset with Low Expression of S100A12.
Journal of immunology (Baltimore, Md. : 1950)
Weinhage T,Kölsche T,Rieger-Fackeldey E,Schmitz R,Antoni AC,Ahlmann M,Foell D,Wittkowski H
Wed Jul 01 00:00:00 UTC 2020
A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02-Expressing Individuals.
Journal of immunology (Baltimore, Md. : 1950)
Rowntree LC,Nguyen THO,Farenc C,Halim H,Hensen L,Rossjohn J,Kotsimbos TC,Purcell AW,Kedzierska K,Gras S,Mifsud NA
Tue Sep 15 00:00:00 UTC 2020
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Oba T,Hoki T,Yamauchi T,Keler T,Marsh HC,Cao X,Ito F
Thu Oct 01 00:00:00 UTC 2020
IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ridley ML,Fleskens V,Roberts CA,Lalnunhlimi S,Alnesf A,O'Byrne AM,Steel KJA,Povoleri GAM,Sumner J,Lavender P,Taams LS
Mon Jun 01 00:00:00 UTC 2020
Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression.
Journal of immunology (Baltimore, Md. : 1950)
Batra L,Shrestha P,Zhao H,Woodward KB,Togay A,Tan M,Grimany-Nuno O,Malik MT,Coronel MM,García AJ,Shirwan H,Yolcu ES
Fri May 15 00:00:00 UTC 2020
A Sequential Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events.
Journal of immunology (Baltimore, Md. : 1950)
Bouchard-Boivin F,Désy O,Béland S,Gama A,Lapointe I,Lesage J,Côté I,Singbo N,Houde I,De Serres SA
Tue Dec 15 00:00:00 UTC 2020
Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function.
Journal of immunology (Baltimore, Md. : 1950)
Yarosz EL,Ye C,Kumar A,Black C,Choi EK,Seo YA,Chang CH
Wed Apr 01 00:00:00 UTC 2020
Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function.
Journal of immunology (Baltimore, Md. : 1950)
Yarosz EL,Ye C,Kumar A,Black C,Choi EK,Seo YA,Chang CH
Wed Apr 01 00:00:00 UTC 2020
Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Høgh RI,Droujinine A,Møller SH,Jepsen SD,Mellergaard M,Andresen L,Skov S
Wed Apr 01 00:00:00 UTC 2020
Cutting Edge: CRISPR-Based Transcriptional Regulators Reveal Transcription-Dependent Establishment of Epigenetic Memory of Foxp3 in Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Cameron J,Martino P,Nguyen L,Li X
Tue Dec 01 00:00:00 UTC 2020
Characterization of Clozapine-Responsive Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ogese MO,Lister A,Jenkins RE,Meng X,Alfirevic A,Douglas L,Mcloughlin R,Silva E,Park BK,Pirmohamed M,Naisbitt DJ
Sun Nov 01 00:00:00 UTC 2020
An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Andrä I,Ulrich H,Dürr S,Soll D,Henkel L,Angerpointner C,Ritter J,Przibilla S,Stadler H,Effenberger M,Busch DH,Schiemann M
Sat Feb 01 00:00:00 UTC 2020
IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro.
Journal of Cancer
Hu JQ,Lei BW,Wen D,Ma B,Zhang TT,Lu ZW,Wei WJ,Wang YL,Wang Y,Li DS,Ji QH,Liao T
200-02 was used in Cell Culture to investigate the effect of IL-2 on MHC class I expression in PTC cells and immune activation with experimental treatment for PTC using PTC cell lines.
Mon Sep 28 00:00:00 UTC 2020
A novel CD2 staining-based flow cytometric assay for assessment of natural killer cell cytotoxicity.
Journal of clinical laboratory analysis
Zhang D,Teng R,Lv N,Lei L,Wang Y,Williamson RA,Chen P,Gao P,O'Dwyer M,Li A,Hu J
Tue Dec 01 00:00:00 UTC 2020
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
Cell death & disease
Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA
Fri Aug 14 00:00:00 UTC 2020
An Integrated Strategy for Identifying Targets of Ubiquitin-Mediated Degradation in CD4+ T Cells.
Methods in molecular biology (Clifton, N.J.)
Field NS,O'Leary CE,Dybas JM,Ding H,Oliver PM
200-02 was used in Cell Culture to describe a strategy integrating RNA, protein, and posttranslational modification datasets to identify targets of ubiquitin-mediated degradation.
Tue Jan 26 00:00:00 UTC 2021
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.
Nature cancer
Zavidij O,Haradhvala NJ,Mouhieddine TH,Sklavenitis-Pistofidis R,Cai S,Reidy M,Rahmat M,Flaifel A,Ferland B,Su NK,Agius MP,Park J,Manier S,Bustoros M,Huynh D,Capelletti M,Berrios B,Liu CJ,He MX,Braggio E,Fonseca R,Maruvka YE,Guerriero JL,Goldman M,Van Allen EM,McCarroll SA,Azzi J,Getz G,Ghobrial IM
200-02 was used in Cell Culture to demonstrate early immune changes during patient progression.
Fri May 01 00:00:00 UTC 2020
The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.
Cells
Langer S,Yin X,Diaz A,Portillo AJ,Gordon DE,Rogers UH,Marlett JM,Krogan NJ,Young JAT,Pache L,Chanda SK
200-02 was used in Cell Culture to indicate that Cul3 is a negative regulator of HIV-1 transcription which governs productive viral replication in infected cells.
Tue Sep 01 00:00:00 UTC 2020
T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Current protocols in immunology
Rollins MR,Spartz EJ,Stromnes IM
200-02 was used in Cell Culture to synthesize and expand upon methodologies to generate, isolate, and engineer human T cells with tumor-reactive TCRs for adoptive cell therapy.
Mon Jun 01 00:00:00 UTC 2020
Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.
FASEB bioAdvances
Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T
Sat Aug 01 00:00:00 UTC 2020
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Cell death & disease
Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC
Mon Mar 02 00:00:00 UTC 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
Tue Jan 14 00:00:00 UTC 2020
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes.
Science advances
Menasche BL,Davis EM,Wang S,Ouyang Y,Li S,Yu H,Shen J
200-02 was used in Cell Culture to identify mechanisms utilised by major histocompatibility complex-unrestricted cytotoxic lymphocytes in tumour killing.
Sun Nov 01 00:00:00 UTC 2020
Bioactivity and safety of B7-H3-targeted chimeric antigen receptor T cells against anaplastic meningioma.
Clinical & translational immunology
Tang X,Liu F,Liu Z,Cao Y,Zhang Z,Wang Y,Huang J,Fan S,Zhao S,Chen Y,Li G,Wang S,Zheng M,Hu Y,Li H,Jiang C,Yang M,Yang H,Xu J,Guo G,Tong A,Zhou L
Fri Apr 15 00:00:00 UTC 2022
Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities.
Scientific reports
Fertey J,Thoma M,Beckmann J,Bayer L,Finkensieper J,Reißhauer S,Berneck BS,Issmail L,Schönfelder J,Casado JP,Poremba A,Rögner FH,Standfest B,Makert GR,Walcher L,Kistenmacher AK,Fricke S,Grunwald T,Ulbert S
Thu Jul 30 00:00:00 UTC 2020
Human mast cells exhibit an individualized pattern of antimicrobial responses.
Immunity, inflammation and disease
Garcia-Rodriguez KM,Bahri R,Sattentau C,Roberts IS,Goenka A,Bulfone-Paus S
Mon Jun 01 00:00:00 UTC 2020
Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag.
The Journal of biological chemistry
Ozono S,Zhang Y,Tobiume M,Kishigami S,Tokunaga K
Fri Sep 11 00:00:00 UTC 2020
Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma.
Oncoimmunology
Sneddon S,Rive CM,Ma S,Dick IM,Allcock RJN,Brown SD,Holt RA,Watson M,Leary S,Lee YCG,Robinson BWS,Creaney J
200-02 was used in Cell Culture to use leural effusions to gain access to malignant mesothelioma (MM) tumor cells as well as immune cells in order to characterize the tumor-immune interface in MM and characterize the landscape of potential neoantigens from SNVs. To determine the existence of candidate neoantigens in MM depsite low mutation burden.
Wed Jul 28 00:00:00 UTC 2021
CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation.
Scientific reports
Elmetwali T,Salman A,Wei W,Hussain SA,Young LS,Palmer DH
Wed Jan 15 00:00:00 UTC 2020
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
Nature communications
Evnouchidou I,Chappert P,Benadda S,Zucchetti A,Weimershaus M,Bens M,Caillens V,Koumantou D,Lotersztajn S,van Endert P,Davoust J,Guermonprez P,Hivroz C,Gross DA,Saveanu L
Tue Jun 02 00:00:00 UTC 2020
Promoter choice: Who should drive the CAR in T cells?
PloS one
Rad S M AH,Poudel A,Tan GMY,McLellan AD
200-02 was used in Cell Culture to compare the ability of the strong well-characterized promoters CMV, EF-1, hPGK and RPBSA to drive functional expression of a single RNA encoding three products: GFP, CAR, plus an additional cell-survival gene, Mcl-1.
Tue Sep 08 00:00:00 UTC 2020
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals.
The Journal of biological chemistry
Philips EA,Garcia-España A,Tocheva AS,Ahearn IM,Adam KR,Pan R,Mor A,Kong XP
Fri Apr 03 00:00:00 UTC 2020
Development and characterisation of NKp44-based chimeric antigen receptors that confer T cells with NK cell-like specificity.
Clinical & translational immunology
Kasahara Y,Shin C,Kubo N,Mihara K,Iwabuchi H,Takachi T,Imamura M,Saitoh A,Imai C
Fri Apr 15 00:00:00 UTC 2022
Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta.
Cell reports
Tang Y,Woodward BO,Pastor L,George AM,Petrechko O,Nouvet FJ,Haas DW,Jiang G,Hildreth JEK
200-02 was used in Cell Culture to find that syncytin, the envelope glycoprotein of human endogenous retrovirus family W1 expressed on placental trophoblasts, triggers cell fusion with HIV-infected T cells.
Tue Mar 31 00:00:00 UTC 2020
Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability.
European journal of immunology
Field NS,Elbulok OA,Dybas JM,Moser EK,Dar AA,Spruce LA,Fazelinia H,Seeholzer SH,Oliver PM
200-02 was used in Cell Culture to identify novel roles for Itch and WBP2 in regulating CD4 T cell proliferation, providing insight into how Itch may prevent inflammation.
Thu Oct 01 00:00:00 UTC 2020
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.
Nature communications
Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
Thu Jul 30 00:00:00 UTC 2020
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells.
Theranostics
Miao L,Qi J,Zhao Q,Wu QN,Wei DL,Wei XL,Liu J,Chen J,Zeng ZL,Ju HQ,Luo HY,Xu RH
200-02 was used in In vitro experiments to unveil a novel function of STING to activate the IL6R-JAK-IL24 pathway in macrophages.
Wed Apr 21 00:00:00 UTC 2021
Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID.
Frontiers in immunology
Deal C,Thauland TJ,Stiehm ER,Garcia-Lloret MI,Butte MJ
200-02 was used in Sample Preparation (FC/FACS) to demonstrate that satisfactory B-cell function can arise as a consequence of both intact IL-21 signaling due to a hypomorphic γc variant, and close HLA matching with the donor to allow for effective T-cell help.
Mon Mar 08 00:00:00 UTC 2021
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.
Nature communications
Tseng HC,Xiong W,Badeti S,Yang Y,Ma M,Liu T,Ramos CA,Dotti G,Fritzky L,Jiang JG,Yi Q,Guarrera J,Zong WX,Liu C,Liu D
Wed Sep 23 00:00:00 UTC 2020
B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells.
Oncoimmunology
Lu H,Shi T,Wang M,Li X,Gu Y,Zhang X,Zhang G,Chen W
200-02 was used in In vitro experiments to study the effect of B7-H3 inhibition or blockade in colon cancer.
Wed Jul 14 00:00:00 UTC 2021
Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Nalin AP,Kowalski JJ,Sprague AC,Schumacher BK,Gerhardt AG,Youssef Y,Vedantam KV,Zhang X,Siebel CW,Mace EM,Caligiuri MA,Mundy-Bosse BL,Freud AG
Sun Nov 15 00:00:00 UTC 2020
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment.
Nature communications
Zheng Y,Chen Z,Han Y,Han L,Zou X,Zhou B,Hu R,Hao J,Bai S,Xiao H,Li WV,Bueker A,Ma Y,Xie G,Yang J,Chen S,Li H,Cao J,Shen L
Tue Dec 08 00:00:00 UTC 2020
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9.
Nature communications
Liu L,Bi E,Ma X,Xiong W,Qian J,Ye L,Su P,Wang Q,Xiao L,Yang M,Lu Y,Yi Q
Thu Nov 19 00:00:00 UTC 2020
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.
Communications biology
Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC
200-02 was used in Sample Preparation (FC/FACS) to demonstrate that the exclusive ligand-receptor partnering enabled the targeted delivery of a mutant form of IL-2 to selectively promote the expansion of convertibleCAR-T cells in vitro and in vivo.
Tue Jun 09 00:00:00 UTC 2020
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.
Communications biology
Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC
200-02 was used in Sample Preparation (FC/FACS) to demonstrate that the exclusive ligand-receptor partnering enabled the targeted delivery of a mutant form of IL-2 to selectively promote the expansion of convertibleCAR-T cells in vitro and in vivo.
Tue Jun 09 00:00:00 UTC 2020
Calreticulin increases growth and progression of natural killer/T-cell lymphoma.
Aging
Zheng Y,Li C,Xin P,Peng Q,Zhang W,Liu S,Zhu X
200-02 was used in Cell Culture to study the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL) to show that CALR regulates the growth and progression of NKTCL cells by modulating G1-to-S cell cycle progression and epithelial-to-mesenchymal transition (EMT).
Wed Nov 18 00:00:00 UTC 2020
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.
Nature communications
Salzer B,Schueller CM,Zajc CU,Peters T,Schoeber MA,Kovacic B,Buri MC,Lobner E,Dushek O,Huppa JB,Obinger C,Putz EM,Holter W,Traxlmayr MW,Lehner M
Thu Aug 20 00:00:00 UTC 2020
Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions.
The Journal of biological chemistry
Tocheva AS,Peled M,Strazza M,Adam KR,Lerrer S,Nayak S,Azoulay-Alfaguter I,Foster CJR,Philips EA,Neel BG,Ueberheide B,Mor A
Fri Dec 25 00:00:00 UTC 2020
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Nature communications
Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H
Thu Dec 10 00:00:00 UTC 2020
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.
Cell stem cell
Vora P,Venugopal C,Salim SK,Tatari N,Bakhshinyan D,Singh M,Seyfrid M,Upreti D,Rentas S,Wong N,Williams R,Qazi MA,Chokshi C,Ding A,Subapanditha M,Savage N,Mahendram S,Ford E,Adile AA,McKenna D,McFarlane N,Huynh V,Wylie RG,Pan J,Bramson J,Hope K,Moffat J,Singh S
200-02 was used in Cell Culture to investigate if CD133-specific chimeric antigen receptor T cells may be a therapeutically tractable strategy to target CD133+ cancer stem cells in human glioblastoma or other treatment-resistant primary cancers.
Thu Jun 04 00:00:00 UTC 2020
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction.
Nature metabolism
Wang T,Gnanaprakasam JNR,Chen X,Kang S,Xu X,Sun H,Liu L,Rodgers H,Miller E,Cassel TA,Sun Q,Vicente-Muñoz S,Warmoes MO,Lin P,Piedra-Quintero ZL,Guerau-de-Arellano M,Cassady KA,Zheng SG,Yang J,Lane AN,Song X,Fan TW,Wang R
Wed Jul 01 00:00:00 UTC 2020
Radiation-induced small extracellular vesicles as "carriages" promote tumor antigen release and trigger antitumor immunity.
Theranostics
Lin W,Xu Y,Chen X,Liu J,Weng Y,Zhuang Q,Lin F,Huang Z,Wu S,Ding J,Chen L,Qiu X,Zhang L,Wu J,Lin D,Qiu S
200-02 was used in In vitro experiments to study the role of small extracellular vesicles (sEVs) in radiation therapy induced antitumor immunity to demonstrate that the use of sEVs secreted by irradiated tumor cells constitutes an efficient approach for tumor antigen delivery and presentation and highlight the role of sEVs in radiation-triggered antitumor immunity.
Thu May 13 00:00:00 UTC 2021
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule.
Cell reports. Medicine
Berezhnoy A,Sumrow BJ,Stahl K,Shah K,Liu D,Li J,Hao SS,De Costa A,Kaul S,Bendell J,Cote GM,Luke JJ,Sanborn RE,Sharma MR,Chen F,Li H,Diedrich G,Bonvini E,Moore PA
200-02 was used in Cell Culture to conclude that MGD019 demonstrates encouraging activity in tumors traditionally unresponsive to checkpoint blockade.
Tue Dec 22 00:00:00 UTC 2020
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
Cancer research
Sun L,Li CW,Chung EM,Yang R,Kim YS,Park AH,Lai YJ,Yang Y,Wang YH,Liu J,Qiu Y,Khoo KH,Yao J,Hsu JL,Cha JH,Chan LC,Hsu JM,Lee HH,Yoo SS,Hung MC
200-02 was used in Cell Culture to demonstrate that glycosylation of PD-1 is functionally significant and targeting glycosylated PD-1 may serve as a means to improve immunotherapy response.
Mon Jun 01 00:00:00 UTC 2020
Metabolism of short-chain fatty acid propionate induces surface expression of NKG2D ligands on cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Høgh RI,Møller SH,Jepsen SD,Mellergaard M,Lund A,Pejtersen M,Fitzner E,Andresen L,Skov S
200-02 was used in In vitro experiments to support that propionate causes metabolic changes resulting in NKG2D ligand surface expression, which holds potential as an immune activating anticancer therapy.
Sun Nov 01 00:00:00 UTC 2020
Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells.
Nature biotechnology
Good Z,Borges L,Vivanco Gonzalez N,Sahaf B,Samusik N,Tibshirani R,Nolan GP,Bendall SC
200-02 was used in Sample Preparation (FC/FACS) to trace proteins implicated in division state and time of stem cell memory-like T cells.
Fri Mar 01 00:00:00 UTC 2019
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
Thu May 16 00:00:00 UTC 2019
Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection.
Cell
Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,Glass PJ,Boyd SD,Ahmed R
Thu May 30 00:00:00 UTC 2019
Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
Cell
Watanabe A,McCarthy KR,Kuraoka M,Schmidt AG,Adachi Y,Onodera T,Tonouchi K,Caradonna TM,Bajic G,Song S,McGee CE,Sempowski GD,Feng F,Urick P,Kepler TB,Takahashi Y,Harrison SC,Kelsoe G
Thu May 16 00:00:00 UTC 2019
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Immunity
Yang Y,Li L,Yuan L,Zhou X,Duan J,Xiao H,Cai N,Han S,Ma X,Liu W,Chen CC,Wang L,Li X,Chen J,Kang N,Chen J,Shen Z,Malwal SR,Liu W,Shi Y,Oldfield E,Guo RT,Zhang Y
Tue Apr 16 00:00:00 UTC 2019
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.
Immunity
Pai CS,Huang JT,Lu X,Simons DM,Park C,Chang A,Tamaki W,Liu E,Roybal KT,Seagal J,Chen M,Hagihara K,Wei XX,DuPage M,Kwek SS,Oh DY,Daud A,Tsai KK,Wu C,Zhang L,Fasso M,Sachidanandam R,Jayaprakash A,Lin I,Casbon AJ,Kinsbury GA,Fong L
Tue Feb 19 00:00:00 UTC 2019
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.
Immunity
Bachem A,Makhlouf C,Binger KJ,de Souza DP,Tull D,Hochheiser K,Whitney PG,Fernandez-Ruiz D,Dähling S,Kastenmüller W,Jönsson J,Gressier E,Lew AM,Perdomo C,Kupz A,Figgett W,Mackay F,Oleshansky M,Russ BE,Parish IA,Kallies A,McConville MJ,Turner SJ,Gebhardt T,Bedoui S
Tue Aug 20 00:00:00 UTC 2019
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.
Immunity
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR
Tue Jun 18 00:00:00 UTC 2019
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 UTC 2019
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Immunity
Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG
Tue Aug 20 00:00:00 UTC 2019
GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Cancer cell
Mondragón L,Mhaidly R,De Donatis GM,Tosolini M,Dao P,Martin AR,Pons C,Chiche J,Jacquin M,Imbert V,Proïcs E,Boyer L,Doye A,Luciano F,Neels JG,Coutant F,Fabien N,Sormani L,Rubio-Patiño C,Bossowski JP,Muller F,Marchetti S,Villa E,Peyron JF,Gaulard P,Lemonnier F,Asnafi V,Genestier L,Benhida R,Fournié JJ,Passeron T,Ricci JE,Verhoeyen E
Mon Sep 16 00:00:00 UTC 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
200-02 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 UTC 2019
Low-dose chidamide restores immune tolerance in ITP in mice and humans.
Blood
Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M
Thu Feb 14 00:00:00 UTC 2019
Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade.
Blood
Rauch DA,Conlon KC,Janakiram M,Brammer JE,Harding JC,Ye BH,Zang X,Ren X,Olson S,Cheng X,Miljkovic MD,Sundaramoorthi H,Joseph A,Skidmore ZL,Griffith O,Griffith M,Waldmann TA,Ratner L
Thu Oct 24 00:00:00 UTC 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
200-02 was used in In vitro experiments to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 UTC 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
200-02 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 UTC 2019
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy.
The Journal of clinical investigation
Xu YP,Lv L,Liu Y,Smith MD,Li WC,Tan XM,Cheng M,Li Z,Bovino M,Aubé J,Xiong Y
Tue Jul 16 00:00:00 UTC 2019
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors.
The Journal of clinical investigation
Chen F,Zou Z,Du J,Su S,Shao J,Meng F,Yang J,Xu Q,Ding N,Yang Y,Liu Q,Wang Q,Sun Z,Zhou S,Du S,Wei J,Liu B
Wed May 01 00:00:00 UTC 2019
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.
The Journal of experimental medicine
Prager I,Liesche C,van Ooijen H,Urlaub D,Verron Q,Sandström N,Fasbender F,Claus M,Eils R,Beaudouin J,Önfelt B,Watzl C
Mon Sep 02 00:00:00 UTC 2019
The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control.
The Journal of experimental medicine
Zhu Y,Zhao Y,Zou L,Zhang D,Aki D,Liu YC
Mon Jul 01 00:00:00 UTC 2019
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
The Journal of experimental medicine
Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ
Mon Jun 03 00:00:00 UTC 2019
A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
The Journal of experimental medicine
Fernandez IZ,Baxter RM,Garcia-Perez JE,Vendrame E,Ranganath T,Kong DS,Lundquist K,Nguyen T,Ogolla S,Black J,Galambos C,Gumbart JC,Dawany N,Kelsen JR,de Zoeten EF,Quinones R,Eissa H,Verneris MR,Sullivan KE,Rochford R,Blish CA,Kedl RM,Dutmer CM,Hsieh EWY
200-02 was used in Enzyme-linked immunosorbent assay to investigate the clinical and immunological phenotypes of two siblings with the first described human IL-2Rβ defect.
Mon Jun 03 00:00:00 UTC 2019
Breaking tolerance with engineered class I antigen-presenting molecules.
Proceedings of the National Academy of Sciences of the United States of America
Parks CA,Henning KR,Pavelko KD,Hansen MJ,Van Keulen VP,Reed BK,Stone JD,Schrum AG,Gil D,Kranz DM,Bordner AJ,Barry MA,Pease LR
Tue Feb 19 00:00:00 UTC 2019
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis.
Proceedings of the National Academy of Sciences of the United States of America
Yu F,Hubrack SZ,Chakraborty S,Sun L,Alcantara-Adap E,Kulkarni R,Billing AM,Graumann J,Taylor CW,Machaca K
Tue May 21 00:00:00 UTC 2019
Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America
Bedard M,Shrestha D,Priestman DA,Wang Y,Schneider F,Matute JD,Iyer SS,Gileadi U,Prota G,Kandasamy M,Veerapen N,Besra G,Fritzsche M,Zeissig S,Shevchenko A,Christianson JC,Platt FM,Eggeling C,Blumberg RS,Salio M,Cerundolo V
Tue Nov 19 00:00:00 UTC 2019
T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces.
Proceedings of the National Academy of Sciences of the United States of America
Jin W,Tamzalit F,Chaudhuri PK,Black CT,Huse M,Kam LC
Tue Oct 01 00:00:00 UTC 2019
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.
Aging cell
Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ
Thu Aug 01 00:00:00 UTC 2019
Human dental pulp stem cells regulate allogeneic NK cells' function via induction of anti-inflammatory purinergic signalling in activated NK cells.
Cell proliferation
Yan F,Liu O,Zhang H,Zhou Y,Zhou D,Zhou Z,He Y,Tang Z,Wang S
Wed May 01 00:00:00 UTC 2019
Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites.
Mucosal immunology
Filbey KJ,Camberis M,Chandler J,Turner R,Kettle AJ,Eichenberger RM,Giacomin P,Le Gros G
Fri Mar 01 00:00:00 UTC 2019
Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses.
Journal of immunology (Baltimore, Md. : 1950)
Onodera T,Hashi K,Shukla RK,Miki M,Takai-Todaka R,Fujimoto A,Kuraoka M,Miyoshi T,Kobayashi K,Hasegawa H,Ato M,Kelsoe G,Katayama K,Takahashi Y
Sun Dec 15 00:00:00 UTC 2019
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Anderson W,Thorpe J,Long SA,Rawlings DJ
Sun Dec 15 00:00:00 UTC 2019
Pyocyanin induces NK92 cell apoptosis via mitochondrial damage and elevated intracellular Ca2.
Innate immunity
Li T,Huang X,Yuan Z,Wang L,Chen M,Su F,Ling X,Piao Z
200-02 was used in Cell Culture to study how pseudomonas aeruginosa-derived pigment pyocyanin (PCN)-induced NK92 cell apoptosis occurs through mitochondrial damage despite inhibiting intracellular reactive oxygen species (ROS) generation.
Tue Jan 01 00:00:00 UTC 2019
Approaches for investigating the extracellular signaling function of ISG15.
Methods in enzymology
Swaim CD,Canadeo LA,Huibregtse JM
200-02 was used in Cell Culture to describe methods for purification of ISG15, preparation, and culture of primary peripheral blood mononuclear cells (PBMCs) and NK-92 cells, assays for IL-12- and ISG15-dependent cytokine (IFN-γ and IL-10) secretion, and assays for initial intracellular signaling events triggered by extracellular ISG15.
Mon Nov 11 00:00:00 UTC 2019
Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells.
Cell reports
Niven J,Madelon N,Page N,Caruso A,Harlé G,Lemeille S,Seemayer CA,Hugues S,Gannagé M
200-02 was used in Sample Preparation (FC/FACS) to study how Tregs are expanded and have phenotypic alterations and impaired suppressive functions in mice with autophagy-deficient dendritic cells (DCs).
Tue Jul 02 00:00:00 UTC 2019
Expansion, isolation and first characterization of bovine Th17 lymphocytes.
Scientific reports
Cunha P,Vern YL,Gitton C,Germon P,Foucras G,Rainard P
Wed Nov 06 00:00:00 UTC 2019
Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection.
The Journal of biological chemistry
Zhang Y,Tada T,Ozono S,Yao W,Tanaka M,Yamaoka S,Kishigami S,Fujita H,Tokunaga K
Fri Mar 08 00:00:00 UTC 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
200-02 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 UTC 2019
Identification of HIV transmitting CD11c+ human epidermal dendritic cells.
Nature communications
Bertram KM,Botting RA,Baharlou H,Rhodes JW,Rana H,Graham JD,Patrick E,Fletcher J,Plasto TM,Truong NR,Royle C,Doyle CM,Tong O,Nasr N,Barnouti L,Kohout MP,Brooks AJ,Wines MP,Haertsch P,Lim J,Gosselink MP,Ctercteko G,Estes JD,Churchill MJ,Cameron PU,Hunter E,Haniffa MA,Cunningham AL,Harman AN
Fri Jun 21 00:00:00 UTC 2019
Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB.
The Journal of biological chemistry
Coorens M,Rao A,Gräfe SK,Unelius D,Lindforss U,Agerberth B,Mjösberg J,Bergman P
Fri Apr 12 00:00:00 UTC 2019
Methamphetamine functions as a novel CD4+ T-cell activator via the sigma-1 receptor to enhance HIV-1 infection.
Scientific reports
Prasad A,Kulkarni R,Shrivastava A,Jiang S,Lawson K,Groopman JE
Wed Jan 30 00:00:00 UTC 2019
High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis.
Scientific reports
Yamin R,Berhani O,Peleg H,Aamar S,Stein N,Gamliel M,Hindi I,Scheiman-Elazary A,Gur C
Mon Feb 04 00:00:00 UTC 2019
Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma.
Cells
Yazdanifar M,Zhou R,Grover P,Williams C,Bose M,Moore LJ,Wu ST,Maher J,Dreau D,Mukherjee AP
200-02 was used in In vitro experiments to show that combination of CAR T cells and biological inhibitors of IDO1, COX1/2, and Gal-9 resulted in significant enhancement of CAR T cell cytotoxicity against PDA cells.
Wed Sep 11 00:00:00 UTC 2019
CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse.
Scientific reports
Taouk G,Hussein O,Zekak M,Abouelghar A,Al-Sarraj Y,Abdelalim EM,Karam M
Wed Jun 19 00:00:00 UTC 2019
Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer.
Cancers
Pan MR,Wu CC,Kan JY,Li QL,Chang SJ,Wu CC,Li CL,Ou-Yang F,Hou MF,Yip HK,Luo CW
200-02 was used in In vitro experiments to find that focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase that regulates several cellular functions in different cells, has the potential to regulate tumor cells sensitized to CIK cells.
Mon Dec 30 00:00:00 UTC 2019
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens.
Nature communications
Pedersen NW,Holm A,Kristensen NP,Bjerregaard AM,Bentzen AK,Marquard AM,Tamhane T,Burgdorf KS,Ullum H,Jennum P,Knudsen S,Hadrup SR,Kornum BR
Tue Feb 19 00:00:00 UTC 2019
iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.
Nature communications
Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B
Fri Mar 22 00:00:00 UTC 2019
Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.
Scientific reports
Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B
Mon Aug 05 00:00:00 UTC 2019
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Nature communications
Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J
Fri Jul 05 00:00:00 UTC 2019
Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity.
The Journal of biological chemistry
Nguyen KG,Gillam FB,Hopkins JJ,Jayanthi S,Gundampati RK,Su G,Bear J,Pilkington GR,Jalah R,Felber BK,Liu J,Thallapuranam SK,Zaharoff DA
Fri Mar 22 00:00:00 UTC 2019
Decidual stromal cells promote the differentiation of CD56bright CD16- NK cells by secreting IL-24 in early pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989)
Yang HL,Zhou WJ,Lu H,Lei ST,Ha SY,Lai ZZ,Zheng ZM,Ruan LY,He YY,Li DJ,Li MQ,Shao J
200-02 was used in Cell Culture to suggest that DSCs promote the differentiation of CD56bright CD16- NK with high levels of inhibitory receptors, immunotolerant, and angiogenic cytokines by secreting IL-24 during decidualization in early pregnancy.
Sat Jun 01 00:00:00 UTC 2019
Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy.
Nature communications
Huang H,Liu Y,Liao W,Cao Y,Liu Q,Guo Y,Lu Y,Xie Z
Tue Oct 22 00:00:00 UTC 2019
Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients.
Scientific reports
Reijnders TDY,Stegeman CA,Huitema MG,Rutgers A,Heeringa P,Abdulahad WH
Tue Jun 04 00:00:00 UTC 2019
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication.
The Journal of biological chemistry
Tirumuru N,Wu L
Fri Mar 01 00:00:00 UTC 2019
T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Han Y,Pan H,Li W,Chen Z,Ma A,Yin T,Liang R,Chen F,Ma Y,Jin Y,Zheng M,Li B,Cai L
Wed Aug 07 00:00:00 UTC 2019
Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.
Scientific reports
Sarkar B,Nishikata I,Nakahata S,Ichikawa T,Shiraga T,Saha HR,Fujii M,Tanaka Y,Shimoda K,Morishita K
Tue Mar 05 00:00:00 UTC 2019
Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding.
Scientific reports
Jarrell JA,Twite AA,Lau KHWJ,Kashani MN,Lievano AA,Acevedo J,Priest C,Nieva J,Gottlieb D,Pawell RS
Fri Mar 01 00:00:00 UTC 2019
Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures.
Scientific reports
van der Waals LM,Laoukili J,Jongen JMJ,Raats DA,Borel Rinkes IHM,Kranenburg O
Mon Jan 28 00:00:00 UTC 2019
Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling.
The Journal of biological chemistry
De Wit F,Pillalamarri SR,Sebastián-Martín A,Venkatesham A,Van Aerschot A,Debyser Z
Fri Aug 02 00:00:00 UTC 2019
Circulating NKp46+ Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer.
Oncoimmunology
Picard E,Godet Y,Laheurte C,Dosset M,Galaine J,Beziaud L,Loyon R,Boullerot L,Lauret Marie Joseph E,Spehner L,Jacquin M,Eberst G,Gaugler B,Le Pimpec-Barthes F,Fabre E,Westeel V,Caignard A,Borg C,Adotévi O
200-02 was used in Cell Culture to investigate subset of NK cell immunosurveillance of non-small cell lung carcinoma.
Tue Jan 12 00:00:00 UTC 2021
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 UTC 2019
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 UTC 2019
LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Frontiers in immunology
Mathew D,Kremer KN,Strauch P,Tigyi G,Pelanda R,Torres RM
200-02 was used in Cell Culture to show that lysophosphatidic acid (LPA) engagement selectively by LPA5 on human and mouse CD8 T cells leads to the inhibition of several early T cell antigen receptor (TCR) signaling events including intracellular calcium mobilization and ERK activation.
Mon Aug 17 00:00:00 UTC 2020
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.
Nature communications
Myers LM,Tal MC,Torrez Dulgeroff LB,Carmody AB,Messer RJ,Gulati G,Yiu YY,Staron MM,Angel CL,Sinha R,Markovic M,Pham EA,Fram B,Ahmed A,Newman AM,Glenn JS,Davis MM,Kaech SM,Weissman IL,Hasenkrug KJ
Fri Feb 15 00:00:00 UTC 2019
A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155.
Molecular & cellular proteomics : MCP
Husain B,Ramani SR,Chiang E,Lehoux I,Paduchuri S,Arena TA,Patel A,Wilson B,Chan P,Franke Y,Wong AW,Lill JR,Turley SJ,Gonzalez LC,Grogan JL,Martinez-Martin N
Fri Nov 01 00:00:00 UTC 2019
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.
Scientific reports
Nyanhete TE,Frisbee AL,Bradley T,Faison WJ,Robins E,Payne T,Freel SA,Sawant S,Weinhold KJ,Wiehe K,Haynes BF,Ferrari G,Li QJ,Moody MA,Tomaras GD
Mon Jul 15 00:00:00 UTC 2019
Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.
Scientific reports
Bonne-Année S,Bush MC,Nutman TB
Fri Oct 04 00:00:00 UTC 2019
Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery.
Scientific reports
Fierle JK,Abram-Saliba J,Brioschi M,deTiani M,Coukos G,Dunn SM
Fri Sep 06 00:00:00 UTC 2019
Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries.
Nature communications
Sharma G,Rive CM,Holt RA
Mon Oct 07 00:00:00 UTC 2019
Vaccination to prevent T cell subversion can protect against persistent hepacivirus infection.
Nature communications
Hartlage AS,Murthy S,Kumar A,Trivedi S,Dravid P,Sharma H,Walker CM,Kapoor A
Thu Mar 07 00:00:00 UTC 2019
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
Nature communications
Li Z,Zhang X,Xue W,Zhang Y,Li C,Song Y,Mei M,Lu L,Wang Y,Zhou Z,Jin M,Bian Y,Zhang L,Wang X,Li L,Li X,Fu X,Sun Z,Wu J,Nan F,Chang Y,Yan J,Yu H,Feng X,Wang G,Zhang D,Fu X,Zhang Y,Young KH,Li W,Zhang M
Mon Sep 16 00:00:00 UTC 2019
The WNT/β-catenin signaling inhibitor XAV939 enhances the elimination of LNCaP and PC-3 prostate cancer cells by prostate cancer patient lymphocytes in vitro.
Scientific reports
Stakheev D,Taborska P,Strizova Z,Podrazil M,Bartunkova J,Smrz D
Mon Mar 18 00:00:00 UTC 2019
Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor.
Cell reports
Shen E,Rabe H,Luo L,Wang L,Wang Q,Yin J,Yang X,Liu W,Sido JM,Nakagawa H,Ao L,Kim HJ,Cantor H,Leavenworth JW
200-02 was used in Cell Culture to show that expression of Blimp1 by FoxP3+ TFR cells is essential for TFR lineage stability, entry into the GC, and expression of regulatory activity.
Tue Nov 12 00:00:00 UTC 2019
Significantly increased anti-tumor activity of carcinoembryonic antigen-specific chimeric antigen receptor T cells in combination with recombinant human IL-12.
Cancer medicine
Chi X,Yang P,Zhang E,Gu J,Xu H,Li M,Gao X,Li X,Zhang Y,Xu H,Hu J
Thu Aug 01 00:00:00 UTC 2019
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
Nature communications
Adachi Y,Tonouchi K,Nithichanon A,Kuraoka M,Watanabe A,Shinnakasu R,Asanuma H,Ainai A,Ohmi Y,Yamamoto T,Ishii KJ,Hasegawa H,Takeyama H,Lertmemongkolchai G,Kurosaki T,Ato M,Kelsoe G,Takahashi Y
Wed Aug 28 00:00:00 UTC 2019
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
Cell chemical biology
Mo X,Tang C,Niu Q,Ma T,Du Y,Fu H
200-02 was used in Cell Culture to develop a high-throughput immunomodulator phenotypic screening platform, HTiP, which integrates the immune and cancer cell co-culture system with imaging- and biochemical-based multiplexed readouts.
Thu Mar 21 00:00:00 UTC 2019
Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers.
Cell reports
Vono M,Eberhardt CS,Auderset F,Mastelic-Gavillet B,Lemeille S,Christensen D,Andersen P,Lambert PH,Siegrist CA
200-02 was used in Cell Culture to understand the mechanisms that allow maternal antibodies to protect offspring from infections but limit their responses to vaccination.
Tue Aug 13 00:00:00 UTC 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 UTC 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 UTC 2019
Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iTR35 conversion.
Nature communications
Liu J,Hao S,Chen X,Zhao H,Du L,Ren H,Wang C,Mao H
Thu Oct 10 00:00:00 UTC 2019
Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Scientific reports
Vautrin A,Manchon L,Garcel A,Campos N,Lapasset L,Laaref AM,Bruno R,Gislard M,Dubois E,Scherrer D,Ehrlich JH,Tazi J
Mon Jan 28 00:00:00 UTC 2019
Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.
Current protocols in immunology
Souter MNT,Loh L,Li S,Meehan BS,Gherardin NA,Godfrey DI,Rossjohn J,Fairlie DP,Kedzierska K,Pellicci DG,Chen Z,Kjer-Nielsen L,Corbett AJ,McCluskey J,Eckle SBG
200-02 was used in Cell Culture to describe protocols to characterize the phenotype of human MAIT cells in blood and tissues by flow cytometry using fluorescently labeled human MR1 tetramers alongside antibodies specific for MAIT cell markers.
Sun Dec 01 00:00:00 UTC 2019
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Nature communications
Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R
Tue May 07 00:00:00 UTC 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 UTC 2019
Continuous targeted kinase inhibitors treatment induces upregulation of PD-L1 in resistant NSCLC.
Scientific reports
Jiang L,Guo F,Liu X,Li X,Qin Q,Shu P,Li Y,Wang Y
Wed Mar 06 00:00:00 UTC 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 UTC 2018
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 UTC 2018
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 UTC 2018
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Cell
Bradley T,Peppa D,Pedroza-Pacheco I,Li D,Cain DW,Henao R,Venkat V,Hora B,Chen Y,Vandergrift NA,Overman RG,Edwards RW,Woods CW,Tomaras GD,Ferrari G,Ginsburg GS,Connors M,Cohen MS,Moody MA,Borrow P,Haynes BF
Thu Oct 04 00:00:00 UTC 2018
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell
Sibener LV,Fernandes RA,Kolawole EM,Carbone CB,Liu F,McAffee D,Birnbaum ME,Yang X,Su LF,Yu W,Dong S,Gee MH,Jude KM,Davis MM,Groves JT,Goddard WA,Heath JR,Evavold BD,Vale RD,Garcia KC
Thu Jul 26 00:00:00 UTC 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 UTC 2018
Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
Immunity
McCarthy KR,Watanabe A,Kuraoka M,Do KT,McGee CE,Sempowski GD,Kepler TB,Schmidt AG,Kelsoe G,Harrison SC
Tue Jan 16 00:00:00 UTC 2018
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
Immunity
Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler G,Huang SC,Pearce EL,Pearce EJ
Tue Dec 18 00:00:00 UTC 2018
CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.
Immunity
Chen L,Youssef Y,Robinson C,Ernst GF,Carson MY,Young KA,Scoville SD,Zhang X,Harris R,Sekhri P,Mansour AG,Chan WK,Nalin AP,Mao HC,Hughes T,Mace EM,Pan Y,Rustagi N,Chatterjee SS,Gunaratne PH,Behbehani GK,Mundy-Bosse BL,Caligiuri MA,Freud AG
Tue Sep 18 00:00:00 UTC 2018
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Immunity
Burrack KS,Huggins MA,Taras E,Dougherty P,Henzler CM,Yang R,Alter S,Jeng EK,Wong HC,Felices M,Cichocki F,Miller JS,Hart GT,Johnson AJ,Jameson SC,Hamilton SE
Tue Apr 17 00:00:00 UTC 2018
Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.
Immunity
Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X
Tue Jul 17 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.
The Journal of clinical investigation
Mathews DV,Dong Y,Higginbotham LB,Kim SC,Breeden CP,Stobert EA,Jenkins J,Tso JY,Larsen CP,Adams AB
Mon Oct 01 00:00:00 UTC 2018
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors.
The Journal of experimental medicine
Brummelman J,Mazza EMC,Alvisi G,Colombo FS,Grilli A,Mikulak J,Mavilio D,Alloisio M,Ferrari F,Lopci E,Novellis P,Veronesi G,Lugli E
Mon Oct 01 00:00:00 UTC 2018
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Chheda ZS,Kohanbash G,Okada K,Jahan N,Sidney J,Pecoraro M,Yang X,Carrera DA,Downey KM,Shrivastav S,Liu S,Lin Y,Lagisetti C,Chuntova P,Watchmaker PB,Mueller S,Pollack IF,Rajalingam R,Carcaboso AM,Mann M,Sette A,Garcia KC,Hou Y,Okada H
Tue Jan 02 00:00:00 UTC 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 UTC 2018
Mechanogenetics for the remote and noninvasive control of cancer immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Pan Y,Yoon S,Sun J,Huang Z,Lee C,Allen M,Wu Y,Chang YJ,Sadelain M,Shung KK,Chien S,Wang Y
Tue Jan 30 00:00:00 UTC 2018
Transdifferentiation of human adult peripheral blood T cells into neurons.
Proceedings of the National Academy of Sciences of the United States of America
Tanabe K,Ang CE,Chanda S,Olmos VH,Haag D,Levinson DF,Südhof TC,Wernig M
Tue Jun 19 00:00:00 UTC 2018
Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America
Mahgoub M,Yasunaga JI,Iwami S,Nakaoka S,Koizumi Y,Shimura K,Matsuoka M
Tue Feb 06 00:00:00 UTC 2018
Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America
Bethune MT,Li XH,Yu J,McLaughlin J,Cheng D,Mathis C,Moreno BH,Woods K,Knights AJ,Garcia-Diaz A,Wong S,Hu-Lieskovan S,Puig-Saus C,Cebon J,Ribas A,Yang L,Witte ON,Baltimore D
Tue Nov 06 00:00:00 UTC 2018
Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes.
Experimental & molecular medicine
Min J,Yang D,Kim M,Haam K,Yoo A,Choi JH,Schraml BU,Kim YS,Kim D,Kang SJ
Fri Mar 16 00:00:00 UTC 2018
Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation.
Cancer immunology research
Borrelli C,Ricci B,Vulpis E,Fionda C,Ricciardi MR,Petrucci MT,Masuelli L,Peri A,Cippitelli M,Zingoni A,Santoni A,Soriani A
200-02 was used in In vitro experiments to demonstrate that low doses of chemotherapeutic drugs induce tumour cell senescence and a senescence-associated secretory phenotype thus promoting IL15 trans-presentation to NK cells leading to their activation and proliferation.
Sun Jul 01 00:00:00 UTC 2018
Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels.
Molecular oncology
Xu L,Chen X,Shen M,Yang DR,Fang L,Weng G,Tsai Y,Keng PC,Chen Y,Lee SO
200-02 was used in Cell Culture to investigate whether IL-6 signaling affects the susceptibility of castration resistant prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells.
Thu Mar 01 00:00:00 UTC 2018
Recombinant Adenovirus KGHV500 and CIK Cells Codeliver Anti-p21-Ras scFv for the Treatment of Gastric Cancer with Wild-Type Ras Overexpression.
Molecular therapy oncolytics
Wang M,Hong Y,Feng Q,Pan X,Song S,Cui J,Lei J,Fang H,Yang J
200-02 was used in Cell Culture to study the antitumor effects of the recombinant oncolytic adenovirus carried by cytokine-induced killer (CIK) cells on n human gastric SGC7901 cells that overexpress wild-type Ras.
Fri Dec 21 00:00:00 UTC 2018
Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells.
International journal of oncology
Shen M,Chen Y,Xu L,Zhu R,Xue X,Tsai Y,Keng PC,Lee SO,Chen Y
200-02 was used in Cell Culture to suggest the existence of a malignant loop characterized by increased macrophage infiltration into radioresistant lung cancer cells which, in turn, promotes the development of the additional resistance of these cells to NK cell cytotoxicity.
Sun Jul 01 00:00:00 UTC 2018
Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Akkaya B,Roesler AS,Miozzo P,Theall BP,Al Souz J,Smelkinson MG,Kabat J,Traba J,Sack MN,Brzostowski JA,Pena M,Dorward DW,Pierce SK,Akkaya M
Sat Dec 01 00:00:00 UTC 2018
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
Journal of immunology (Baltimore, Md. : 1950)
Woo JS,Srikanth S,Kim KD,Elsaesser H,Lu J,Pellegrini M,Brooks DG,Sun Z,Gwack Y
Wed Aug 15 00:00:00 UTC 2018
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Journal of immunology (Baltimore, Md. : 1950)
Nissen SK,Pedersen JG,Helleberg M,Kjær K,Thavachelvam K,Obel N,Tolstrup M,Jakobsen MR,Mogensen TH
Tue May 15 00:00:00 UTC 2018
miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Zhang T,Zhang Z,Li F,Ping Y,Qin G,Zhang C,Zhang Y
Mon Oct 01 00:00:00 UTC 2018
Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Aue G,Sun C,Liu D,Park JH,Pittaluga S,Tian X,Lee E,Soto S,Valdez J,Maric I,Stetler-Stevenson M,Yuan C,Nakamura Y,Muranski P,Wiestner A
Mon Oct 01 00:00:00 UTC 2018
Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Tan X,Ding Y,Zhu P,Dou R,Liang Z,Yang D,Huang Z,Wang W,Wu X,Weng X
Tue May 15 00:00:00 UTC 2018
CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses.
Journal of immunology (Baltimore, Md. : 1950)
Rogers MC,Lamens KD,Shafagati N,Johnson M,Oury TD,Joyce S,Williams JV
Wed Aug 15 00:00:00 UTC 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 UTC 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 UTC 2018
Multiplexed FluoroSpot for the Analysis of Dengue Virus- and Zika Virus-Specific and Cross-Reactive Memory B Cells.
Journal of immunology (Baltimore, Md. : 1950)
Adam A,Woda M,Kounlavouth S,Rothman AL,Jarman RG,Cox JH,Ledgerwood JE,Gromowski GD,Currier JR,Friberg H,Mathew A
Sat Dec 15 00:00:00 UTC 2018
Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Maricic I,Marrero I,Eguchi A,Nakamura R,Johnson CD,Dasgupta S,Hernandez CD,Nguyen PS,Swafford AD,Knight R,Feldstein AE,Loomba R,Kumar V
Thu Nov 15 00:00:00 UTC 2018
VASP Regulates NK Cell Lytic Granule Convergence.
Journal of immunology (Baltimore, Md. : 1950)
Wilton KM,Billadeau DD
Thu Nov 15 00:00:00 UTC 2018
A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Liu W,Chen Y,Liu J,Wu K,Su L,Zhang W,Jiang Y,Zhang X,Zhang Y,Liu C,Tao L,Liu B,Zhang H
Thu Feb 01 00:00:00 UTC 2018
LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Sharma A,Lawry SM,Klein BS,Wang X,Sherer NM,Zumwalde NA,Gumperz JE
Mon Oct 15 00:00:00 UTC 2018
Multiplexed Division Tracking Dyes for Proliferation-Based Clonal Lineage Tracing.
Journal of immunology (Baltimore, Md. : 1950)
Horton MB,Prevedello G,Marchingo JM,Zhou JHS,Duffy KR,Heinzel S,Hodgkin PD
Wed Aug 01 00:00:00 UTC 2018
SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β.
Nanoscale research letters
Liu H,Dong H,Zhou N,Dong S,Chen L,Zhu Y,Hu HM,Mou Y
200-02 was used in Cell Culture to study the the maturation and migration of interleukin-1β.
Thu Dec 20 00:00:00 UTC 2018
Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Tang YY,Sheng SY,Lu CG,Zhang YQ,Zou JY,Lei YY,Gu Y,Hong H
200-02 was used in Sample Preparation (FC/FACS) to study glycogen synthase kinase-3β inhibitor TWS119 effects on CD4 and CD8 T cells in tumor-infiltrating lymphocytes.
Sat Sep 01 00:00:00 UTC 2018
Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Tang YY,Sheng SY,Lu CG,Zhang YQ,Zou JY,Lei YY,Gu Y,Hong H
200-02 was used in Sample Preparation (FC/FACS) to study glycogen synthase kinase-3β inhibitor TWS119 effects on CD4 and CD8 T cells in tumor-infiltrating lymphocytes.
Sat Sep 01 00:00:00 UTC 2018
The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ.
OncoTargets and therapy
Wang L,Yang X,Li D,Liang Z,Chen Y,Ma G,Wang Y,Li Y,Liang Y,Niu H
200-02 was used in Cell Culture to show that inhibiting glutamine metabolism in bladder cancer cells could reduce the elevation in PD-L1 expression induced by interferon-y (IFN-γ).
Sat Apr 09 00:00:00 UTC 2022
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
200-02 was used in Cell Culture to explore the mechanism of regulatory T cell/Th17 imbalance and the role of high mobility group box-1 protein on the balance in atherosclerosis.
Sat Sep 01 00:00:00 UTC 2018
Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.
Scientific reports
Vasko T,Hoffmann J,Gostek S,Schettgen T,Quinete N,Preisinger C,Kraus T,Ziegler P
Thu Nov 15 00:00:00 UTC 2018
Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression.
Retrovirology
Wang M,Yang W,Chen Y,Wang J,Tan J,Qiao W
200-02 was used in Sample Preparation to investigate the mechanisms of RelB on TAR-independent Tat-mediated LTR transactivation.
Fri Sep 21 00:00:00 UTC 2018
Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages.
Cell death & disease
Xue Y,Xiao H,Guo S,Xu B,Liao Y,Wu Y,Zhang G
Fri Mar 02 00:00:00 UTC 2018
A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity.
Cell death & disease
Xie X,Zhou W,Hu Y,Chen Y,Zhang H,Li Y
Wed Mar 07 00:00:00 UTC 2018
Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells.
Cell reports
Chen J,Li N,Yin Y,Zheng N,Min M,Lin B,Zhang L,Long X,Zhang Y,Cai Z,Zhai S,Qin J,Wang X
200-02 was used in Conjugation assay to conclude that Nsd2 coordinates GCB positive selection by enhancing both BCR signaling and T cell help.
Tue Dec 18 00:00:00 UTC 2018
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.
Nature communications
Dufva O,Kankainen M,Kelkka T,Sekiguchi N,Awad SA,Eldfors S,Yadav B,Kuusanmäki H,Malani D,Andersson EI,Pietarinen P,Saikko L,Kovanen PE,Ojala T,Lee DA,Loughran TP,Nakazawa H,Suzumiya J,Suzuki R,Ko YH,Kim WS,Chuang SS,Aittokallio T,Chan WC,Ohshima K,Ishida F,Mustjoki S
Thu Apr 19 00:00:00 UTC 2018
CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.
Cell reports
Holz LE,Prier JE,Freestone D,Steiner TM,English K,Johnson DN,Mollard V,Cozijnsen A,Davey GM,Godfrey DI,Yui K,Mackay LK,Lahoud MH,Caminschi I,McFadden GI,Bertolino P,Fernandez-Ruiz D,Heath WR
200-02 was used in Cell Culture to investigate the effects of different conditions for liver tissue-resident memory T cell formation.
Tue Oct 02 00:00:00 UTC 2018
IFITM proteins inhibit HIV-1 protein synthesis.
Scientific reports
Lee WJ,Fu RM,Liang C,Sloan RD
Fri Sep 28 00:00:00 UTC 2018
Diminished TLR2-TLR9 mediated CD4+ T cell responses are associated with increased inflammation in intraocular tuberculosis.
Scientific reports
Sharma RK,Sharma J,Khan ZK,Pattekar A,Gupta V,Bansal R,Sharma K,Aggarwal AN,Gupta A,Sachdeva N
Fri Sep 14 00:00:00 UTC 2018
Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.
Nature communications
Issuree PD,Day K,Au C,Raviram R,Zappile P,Skok JA,Xue HH,Myers RM,Littman DR
Wed Sep 05 00:00:00 UTC 2018
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.
Nature communications
Meng X,Grötsch B,Luo Y,Knaup KX,Wiesener MS,Chen XX,Jantsch J,Fillatreau S,Schett G,Bozec A
Wed Jan 17 00:00:00 UTC 2018
Resting T cells are hypersensitive to DNA damage due to defective DNA repair pathway.
Cell death & disease
Hu Q,Xie Y,Ge Y,Nie X,Tao J,Zhao Y
Thu May 31 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure.
Cell discovery
El-Daher MT,Cagnard N,Gil M,Da Cruz MC,Leveau C,Sepulveda F,Zarhrate M,Tores F,Legoix P,Baulande S,de Villartay JP,Almouzni G,Quivy JP,Fischer A,de Saint Basile G
Thu Oct 01 00:00:00 UTC 2020
CD45+CD33lowCD11bdim myeloid-derived suppressor cells suppress CD8+ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer.
Cell death & disease
Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y
Mon Jul 09 00:00:00 UTC 2018
MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.
The Journal of biological chemistry
Shams K,Kurowska-Stolarska M,Schütte F,Burden AD,McKimmie CS,Graham GJ
Fri Feb 23 00:00:00 UTC 2018
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release.
Nature communications
Kononchik J,Ireland J,Zou Z,Segura J,Holzapfel G,Chastain A,Wang R,Spencer M,He B,Stutzman N,Kano D,Arthos J,Fischer E,Chun TW,Moir S,Sun P
Thu Jul 19 00:00:00 UTC 2018
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
eLife
Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R
200-02 was used in Cell Culture to examine the role of glutamine catabolism in fuelling the de novo synthesis of glutathionine, and directing the lineage choice of T cells.
Mon Sep 10 00:00:00 UTC 2018
A cancer vaccine approach for personalized treatment of Lynch Syndrome.
Scientific reports
Majumder S,Shah R,Elias J,Manoharan M,Shah P,Kumari A,Chakraborty P,Kode V,Mistry Y,Coral K,Mittal B,Sm SM,Mahadevan L,Gupta R,Chaudhuri A,Khanna-Gupta A
Tue Aug 14 00:00:00 UTC 2018
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Nature communications
Helsen CW,Hammill JA,Lau VWC,Mwawasi KA,Afsahi A,Bezverbnaya K,Newhook L,Hayes DL,Aarts C,Bojovic B,Denisova GF,Kwiecien JM,Brain I,Derocher H,Milne K,Nelson BH,Bramson JL
Fri Aug 03 00:00:00 UTC 2018
A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells.
Scientific reports
Brey CU,Proff J,Teufert N,Salzer B,Brozy J,Münz M,Pendzialek J,Ensser A,Holter W,Lehner M
Wed Nov 28 00:00:00 UTC 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
200-02 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
Mon Aug 06 00:00:00 UTC 2018
Directed evolution of CRISPR-Cas9 to increase its specificity.
Nature communications
Lee JK,Jeong E,Lee J,Jung M,Shin E,Kim YH,Lee K,Jung I,Kim D,Kim S,Kim JS
Mon Aug 06 00:00:00 UTC 2018
Frequent adaptive immune responses against arginase-1.
Oncoimmunology
Martinenaite E,Mortensen REJ,Hansen M,Orebo Holmström M,Munir Ahmad S,Grønne Dahlager Jørgensen N,Met Ö,Donia M,Svane IM,Andersen MH
200-02 was used in Cell Culture to show that arginase-1-specific T cells were capable of recognizing arginase-1-expressing cells.
Tue Jan 12 00:00:00 UTC 2021
Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.
Scientific reports
Gherardin NA,Loh L,Admojo L,Davenport AJ,Richardson K,Rogers A,Darcy PK,Jenkins MR,Prince HM,Harrison SJ,Quach H,Fairlie DP,Kedzierska K,McCluskey J,Uldrich AP,Neeson PJ,Ritchie DS,Godfrey DI
Wed Mar 07 00:00:00 UTC 2018
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
Cell reports
Kim C,Hu B,Jadhav RR,Jin J,Zhang H,Cavanagh MM,Akondy RS,Ahmed R,Weyand CM,Goronzy JJ
200-02 was used in In vitro experiments to suggest that curbing miR-21 upregulation or activity in older individuals may improve their ability to mount effective vaccine responses.
Tue Nov 20 00:00:00 UTC 2018
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.
Nature communications
Gaddis DE,Padgett LE,Wu R,McSkimming C,Romines V,Taylor AM,McNamara CA,Kronenberg M,Crotty S,Thomas MJ,Sorci-Thomas MG,Hedrick CC
Thu Mar 15 00:00:00 UTC 2018
Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.
Scientific reports
Abrahamsen G,Sundvold-Gjerstad V,Habtamu M,Bogen B,Spurkland A
Thu Sep 06 00:00:00 UTC 2018
A dynamic transcriptomic atlas of cytokine-induced killer cells.
The Journal of biological chemistry
Meng M,Li L,Li R,Wang W,Chen Y,Xie Y,Han R,Zhu K,Huang W,Yang L,Li S,Shi J,Tan W,Gao H,Zhao Y,Yang L,Tan J,Hou Z
Fri Dec 21 00:00:00 UTC 2018
A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses.
Scientific reports
Kasprowicz R,Rand E,O'Toole PJ,Signoret N
Tue May 22 00:00:00 UTC 2018
DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.
Nature communications
Kagoya Y,Nakatsugawa M,Saso K,Guo T,Anczurowski M,Wang CH,Butler MO,Arrowsmith CH,Hirano N
Tue May 15 00:00:00 UTC 2018
δ-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8+ T cell activation.
Oncoimmunology
Huang F,Chen J,Lan R,Wang Z,Chen R,Lin J,Zhang L,Fu L
200-02 was used in Cell Culture to demonstrate that δ-Catenin can be used as a potential tumor-associated antigen for HCC. δ-Catenin peptide vaccines enhance the activation of cytotoxic T lymphocytes, infiltration of CD8+ T cells into tumors, secretion of IFN-γ and the killing of tumor cells by T cells. Therefore δ-Catenin peptide vaccines can enhance activation of T cells via MAPK/ERK signaling and the transcriptional factors Eomes and T-bet.
Tue Jan 12 00:00:00 UTC 2021
Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy.
Scientific reports
Zhang C,Peng Y,Hublitz P,Zhang H,Dong T
Tue Apr 03 00:00:00 UTC 2018
Dysfunctional immunoregulation in human liver allograft rejection associated with compromised galectin-1/CD7 pathway function.
Cell death & disease
Wei S,Cao D,Liu Z,Li J,Wu H,Gong J,Liu Y,Wu Y
Tue Feb 20 00:00:00 UTC 2018
Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma.
Frontiers in immunology
Tognarelli S,Wirsching S,von Metzler I,Rais B,Jacobs B,Serve H,Bader P,Ullrich E
200-02 was used in Cell Culture to investigate the potential use of natural killer cell-specific check point inhibitors in multiple myeloma.
Mon Sep 30 00:00:00 UTC 2019
Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.
Frontiers in immunology
Zhang M,Deng X,Guan X,Geng L,Fu M,Zhang B,Chen R,Hu H,Hu K,Zhang D,Li M,Liu Y,Gong S,Hu Q
200-02 was used in Cell Culture to study the mechanisms of CXCR3 ligands during HSV-2 infection.
Fri Oct 25 00:00:00 UTC 2019
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Nature
Wartewig T,Kurgyis Z,Keppler S,Pechloff K,Hameister E,Öllinger R,Maresch R,Buch T,Steiger K,Winter C,Rad R,Ruland J
200-02 was used in In vitro experiments to evaluate the role of the receptor, Programmed Death 1, in T cell lymphomagenesis, and the potential implications of this in lymphoma therapy.
Thu Dec 07 00:00:00 UTC 2017
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Nature
Burr ML,Sparbier CE,Chan YC,Williamson JC,Woods K,Beavis PA,Lam EYN,Henderson MA,Bell CC,Stolzenburg S,Gilan O,Bloor S,Noori T,Morgens DW,Bassik MC,Neeson PJ,Behren A,Darcy PK,Dawson SJ,Voskoboinik I,Trapani JA,Cebon J,Lehner PJ,Dawson MA
Thu Sep 07 00:00:00 UTC 2017
Mitochondrial Priming by CD28.
Cell
Klein Geltink RI,O'Sullivan D,Corrado M,Bremser A,Buck MD,Buescher JM,Firat E,Zhu X,Niedermann G,Caputa G,Kelly B,Warthorst U,Rensing-Ehl A,Kyle RL,Vandersarren L,Curtis JD,Patterson AE,Lawless S,Grzes K,Qiu J,Sanin DE,Kretz O,Huber TB,Janssens S,Lambrecht BN,Rambold AS,Pearce EJ,Pearce EL
Thu Oct 05 00:00:00 UTC 2017
Systemic Immunity Is Required for Effective Cancer Immunotherapy.
Cell
Spitzer MH,Carmi Y,Reticker-Flynn NE,Kwek SS,Madhireddy D,Martins MM,Gherardini PF,Prestwood TR,Chabon J,Bendall SC,Fong L,Nolan GP,Engleman EG
Thu Jan 26 00:00:00 UTC 2017
Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.
Cell
Galarza-Muñoz G,Briggs FBS,Evsyukova I,Schott-Lerner G,Kennedy EM,Nyanhete T,Wang L,Bergamaschi L,Widen SG,Tomaras GD,Ko DC,Bradrick SS,Barcellos LF,Gregory SG,Garcia-Blanco MA
Thu Mar 23 00:00:00 UTC 2017
Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.
Immunity
Man K,Gabriel SS,Liao Y,Gloury R,Preston S,Henstridge DC,Pellegrini M,Zehn D,Berberich-Siebelt F,Febbraio MA,Shi W,Kallies A
Tue Dec 19 00:00:00 UTC 2017
Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.
Immunity
Zhivaki D,Lemoine S,Lim A,Morva A,Vidalain PO,Schandene L,Casartelli N,Rameix-Welti MA,Hervé PL,Dériaud E,Beitz B,Ripaux-Lefevre M,Miatello J,Lemercier B,Lorin V,Descamps D,Fix J,Eléouët JF,Riffault S,Schwartz O,Porcheray F,Mascart F,Mouquet H,Zhang X,Tissières P,Lo-Man R
Tue Feb 21 00:00:00 UTC 2017
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
Tue Nov 21 00:00:00 UTC 2017
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
Tue Oct 17 00:00:00 UTC 2017
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.
Immunity
Mowel WK,McCright SJ,Kotzin JJ,Collet MA,Uyar A,Chen X,DeLaney A,Spencer SP,Virtue AT,Yang E,Villarino A,Kurachi M,Dunagin MC,Pritchard GH,Stein J,Hughes C,Fonseca-Pereira D,Veiga-Fernandes H,Raj A,Kambayashi T,Brodsky IE,O'Shea JJ,Wherry EJ,Goff LA,Rinn JL,Williams A,Flavell RA,Henao-Mejia J
Tue Sep 19 00:00:00 UTC 2017
Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb.
Immunity
Dias S,D'Amico A,Cretney E,Liao Y,Tellier J,Bruggeman C,Almeida FF,Leahy J,Belz GT,Smyth GK,Shi W,Nutt SL
Tue Jan 17 00:00:00 UTC 2017
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Cancer cell
Spranger S,Dai D,Horton B,Gajewski TF
Mon May 08 00:00:00 UTC 2017
Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes.
Blood
Blázquez-Moreno A,Pérez-Portilla A,Agúndez-Llaca M,Dukovska D,Valés-Gómez M,Aydogmus C,Ikinciogullari A,Regueiro JR,Reyburn HT
Thu Sep 07 00:00:00 UTC 2017
ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.
The Journal of experimental medicine
Lyons JJ,Liu Y,Ma CA,Yu X,O'Connell MP,Lawrence MG,Zhang Y,Karpe K,Zhao M,Siegel AM,Stone KD,Nelson C,Jones N,DiMaggio T,Darnell DN,Mendoza-Caamal E,Orozco L,Hughes JD,McElwee J,Hohman RJ,Frischmeyer-Guerrerio PA,Rothenberg ME,Freeman AF,Holland SM,Milner JD
Mon Mar 06 00:00:00 UTC 2017
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.
The Journal of experimental medicine
Abolhassani H,Edwards ES,Ikinciogullari A,Jing H,Borte S,Buggert M,Du L,Matsuda-Lennikov M,Romano R,Caridha R,Bade S,Zhang Y,Frederiksen J,Fang M,Bal SK,Haskologlu S,Dogu F,Tacyildiz N,Matthews HF,McElwee JJ,Gostick E,Price DA,Palendira U,Aghamohammadi A,Boisson B,Rezaei N,Karlsson AC,Lenardo MJ,Casanova JL,Hammarström L,Tangye SG,Su HC,Pan-Hammarström Q
Sun Jan 01 00:00:00 UTC 2017
Injection of T3SS effectors not resulting in invasion is the main targeting mechanism of Shigella toward human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Pinaud L,Samassa F,Porat Z,Ferrari ML,Belotserkovsky I,Parsot C,Sansonetti PJ,Campbell-Valois FX,Phalipon A
Tue Sep 12 00:00:00 UTC 2017
Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.
Proceedings of the National Academy of Sciences of the United States of America
He N,Fan W,Henriquez B,Yu RT,Atkins AR,Liddle C,Zheng Y,Downes M,Evans RM
Tue Nov 21 00:00:00 UTC 2017
Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy.
The Journal of infectious diseases
Gay CL,Bosch RJ,Ritz J,Hataye JM,Aga E,Tressler RL,Mason SW,Hwang CK,Grasela DM,Ray N,Cyktor JC,Coffin JM,Acosta EP,Koup RA,Mellors JW,Eron JJ
200-02 was used in Cell Culture to conduct a phase I, randomized, double-blind, placebo-controlled, dose-escalating study of BMS-936559, including HIV-1-infected adults aged >18 to 70 years on suppressive antiretroviral therapy with CD4+ counts >350 cells/µL and detectable plasma HIV-1 RNA by single-copy assay.
Thu Jun 01 00:00:00 UTC 2017
Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.
European journal of immunology
Ellinghaus U,Cortini A,Pinder CL,Le Friec G,Kemper C,Vyse TJ
Sat Jul 01 00:00:00 UTC 2017
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Immunology and cell biology
Dockree T,Holland CJ,Clement M,Ladell K,McLaren JE,van den Berg HA,Gostick E,L Miners K,Llewellyn-Lacey S,Bridgeman JS,Man S,Bailey M,Burrows SR,Price DA,Wooldridge L
Sun Jan 01 00:00:00 UTC 2017
Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.
Stem cells (Dayton, Ohio)
Davies LC,Heldring N,Kadri N,Le Blanc K
Wed Mar 01 00:00:00 UTC 2017
Enrichment of Human CCR6+ Regulatory T Cells with Superior Suppressive Activity in Oral Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Lee JJ,Kao KC,Chiu YL,Jung CJ,Liu CJ,Cheng SJ,Chang YL,Ko JY,Chia JS
Sat Jul 15 00:00:00 UTC 2017
Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hutton AJ,Polak ME,Spalluto CM,Wallington JC,Pickard C,Staples KJ,Warner JA,Wilkinson TM
Sun Jan 01 00:00:00 UTC 2017
Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Read KA,Powell MD,Baker CE,Sreekumar BK,Ringel-Scaia VM,Bachus H,Martin RE,Cooley ID,Allen IC,Ballesteros-Tato A,Oestreich KJ
Sun Oct 01 00:00:00 UTC 2017
Sensitivity to Restimulation-Induced Cell Death Is Linked to Glycolytic Metabolism in Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Larsen SE,Bilenkin A,Tarasenko TN,Arjunaraja S,Stinson JR,McGuire PJ,Snow AL
Sun Jan 01 00:00:00 UTC 2017
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chauhan AK
Thu Jun 15 00:00:00 UTC 2017
The Cooperative Role of CD326+ and CD11b+ Dendritic Cell Subsets for a Hapten-Induced Th2 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Cho Y,Kwon D,Kang SJ
Wed Nov 01 00:00:00 UTC 2017
A20 Restrains Thymic Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Fischer JC,Otten V,Kober M,Drees C,Rosenbaum M,Schmickl M,Heidegger S,Beyaert R,van Loo G,Li XC,Peschel C,Schmidt-Supprian M,Haas T,Spoerl S,Poeck H
Sun Oct 01 00:00:00 UTC 2017
TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.
Journal of immunology (Baltimore, Md. : 1950)
Sabins NC,Chornoguz O,Leander K,Kaplan F,Carter R,Kinder M,Bachman K,Verona R,Shen S,Bhargava V,Santulli-Marotto S
Fri Dec 15 00:00:00 UTC 2017
Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ventura E,Weller M,Burghardt I
Thu Jun 15 00:00:00 UTC 2017
Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition.
Scientific reports
Yang L,Shen M,Xu LJ,Yang X,Tsai Y,Keng PC,Chen Y,Lee SO
Fri Aug 11 00:00:00 UTC 2017
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Nature communications
Jespersen H,Lindberg MF,Donia M,Söderberg EMV,Andersen R,Keller U,Ny L,Svane IM,Nilsson LM,Nilsson JA
Wed Sep 27 00:00:00 UTC 2017
Exosomes Derived from HIV-1 Infected DCs Mediate Viral trans-Infection via Fibronectin and Galectin-3.
Scientific reports
Kulkarni R,Prasad A
Wed Nov 01 00:00:00 UTC 2017
Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia.
Scientific reports
Hong CS,Sharma P,Yerneni SS,Simms P,Jackson EK,Whiteside TL,Boyiadzis M
Tue Oct 31 00:00:00 UTC 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
Mon Oct 09 00:00:00 UTC 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
Mon Oct 09 00:00:00 UTC 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
Fri Dec 01 00:00:00 UTC 2017
Absence of Grail promotes CD8+ T cell anti-tumour activity.
Nature communications
Haymaker C,Yang Y,Wang J,Zou Q,Sahoo A,Alekseev A,Singh D,Ritthipichai K,Hailemichael Y,Hoang ON,Qin H,Schluns KS,Wang T,Overwijk WW,Sun SC,Bernatchez C,Kwak LW,Neelapu SS,Nurieva R
Thu Aug 10 00:00:00 UTC 2017
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
The Journal of biological chemistry
Cole DK,van den Berg HA,Lloyd A,Crowther MD,Beck K,Ekeruche-Makinde J,Miles JJ,Bulek AM,Dolton G,Schauenburg AJ,Wall A,Fuller A,Clement M,Laugel B,Rizkallah PJ,Wooldridge L,Sewell AK
Fri Jan 20 00:00:00 UTC 2017
Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.
International journal of molecular sciences
Metzemaekers M,Mortier A,Janssens R,Boff D,Vanbrabant L,Lamoen N,Van Damme J,Teixeira MM,De Meester I,Amaral FA,Proost P
Thu Jul 13 00:00:00 UTC 2017
Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.
Scientific reports
Vahedi F,Nham T,Poznanski SM,Chew MV,Shenouda MM,Lee D,Ashkar AA
Thu Sep 21 00:00:00 UTC 2017
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Scientific reports
Liaskou E,Jeffery L,Chanouzas D,Soskic B,Seldin MF,Harper L,Sansom D,Hirschfield GM
Wed Aug 09 00:00:00 UTC 2017
Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone.
Scientific reports
Lee JH,Park CS,Jang S,Kim JW,Kim SH,Song S,Kim K,Lee CK
Wed Nov 08 00:00:00 UTC 2017
Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins.
Scientific reports
Speir M,Authier-Hall A,Brooks CR,Farrand KJ,Compton BJ,Anderson RJ,Heiser A,Osmond TL,Tang CW,Berzofsky JA,Terabe M,Painter GF,Hermans IF,Weinkove R
Fri Oct 27 00:00:00 UTC 2017
Increased tumor-infiltrating CD45RA-CCR7- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Cell death & disease
Mao FY,Kong H,Zhao YL,Peng LS,Chen W,Zhang JY,Cheng P,Wang TT,Lv YP,Teng YS,Fu XL,Liu YG,Wu XL,Hao CJ,You N,Luo P,Yu PW,Zou QM,Guo G,Zhuang Y
Thu Aug 17 00:00:00 UTC 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 UTC 2017
Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Nature communications
Brownlie RJ,Garcia C,Ravasz M,Zehn D,Salmond RJ,Zamoyska R
Tue Nov 07 00:00:00 UTC 2017
Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.
Nature communications
Al-Mossawi MH,Chen L,Fang H,Ridley A,de Wit J,Yager N,Hammitzsch A,Pulyakhina I,Fairfax BP,Simone D,Yi Y,Bandyopadhyay S,Doig K,Gundle R,Kendrick B,Powrie F,Knight JC,Bowness P
Wed Nov 15 00:00:00 UTC 2017
Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells.
Frontiers in immunology
Battisti F,Napoletano C,Rahimi Koshkaki H,Belleudi F,Zizzari IG,Ruscito I,Palchetti S,Bellati F,Benedetti Panici P,Torrisi MR,Caracciolo G,Altieri F,Nuti M,Rughetti A
200-02 was used in Cell Culture to present pieces of evidence that the internalization of tumor-derived microvesicles modulates antigen-processing machinery of dendritic cells.
Wed Nov 20 00:00:00 UTC 2019
Multiplex single-cell visualization of nucleic acids and protein during HIV infection.
Nature communications
Puray-Chavez M,Tedbury PR,Huber AD,Ukah OB,Yapo V,Liu D,Ji J,Wolf JJ,Engelman AN,Sarafianos SG
Fri Dec 01 00:00:00 UTC 2017
Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection.
Scientific reports
Zhong H,Hu X,Janowski AB,Storch GA,Su L,Cao L,Yu J,Xu J
Tue Dec 19 00:00:00 UTC 2017
Fluorine-19 nuclear magnetic resonance of chimeric antigen receptor T cell biodistribution in murine cancer model.
Scientific reports
Chapelin F,Gao S,Okada H,Weber TG,Messer K,Ahrens ET
Mon Dec 18 00:00:00 UTC 2017
Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway.
Oncotarget
Shen MJ,Xu LJ,Yang L,Tsai Y,Keng PC,Chen Y,Lee SO,Chen Y
200-02 was used in Cell Culture to discover that radiation treatment leads to upregulation of PD-L1 and down-regulation of NKG2D ligands in non-small cell lung cancer cells, thus rendering them resistant to cytotoxic actions of NK cells.
Fri Oct 06 00:00:00 UTC 2017
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.
Cell
Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wendel HG
Thu Oct 06 00:00:00 UTC 2016
Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.
Immunity
Gherardin NA,Keller AN,Woolley RE,Le Nours J,Ritchie DS,Neeson PJ,Birkinshaw RW,Eckle SBG,Waddington JN,Liu L,Fairlie DP,Uldrich AP,Pellicci DG,McCluskey J,Godfrey DI,Rossjohn J
Tue Jan 19 00:00:00 UTC 2016
Inflammasome-Dependent Induction of Adaptive NK Cell Memory.
Immunity
van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V
Tue Jun 21 00:00:00 UTC 2016
A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.
Immunity
Scoville SD,Mundy-Bosse BL,Zhang MH,Chen L,Zhang X,Keller KA,Hughes T,Chen L,Cheng S,Bergin SM,Mao HC,McClory S,Yu J,Carson WE,Caligiuri MA,Freud AG
Tue May 17 00:00:00 UTC 2016
A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.
Immunity
Scoville SD,Mundy-Bosse BL,Zhang MH,Chen L,Zhang X,Keller KA,Hughes T,Chen L,Cheng S,Bergin SM,Mao HC,McClory S,Yu J,Carson WE,Caligiuri MA,Freud AG
Tue May 17 00:00:00 UTC 2016
IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.
Blood
Mao Y,van Hoef V,Zhang X,Wennerberg E,Lorent J,Witt K,Masvidal L,Liang S,Murray S,Larsson O,Kiessling R,Lundqvist A
Thu Sep 15 00:00:00 UTC 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 UTC 2016
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.
The Journal of clinical investigation
Kagoya Y,Nakatsugawa M,Yamashita Y,Ochi T,Guo T,Anczurowski M,Saso K,Butler MO,Arrowsmith CH,Hirano N
Thu Sep 01 00:00:00 UTC 2016
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.
The Journal of clinical investigation
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E
Tue Nov 01 00:00:00 UTC 2016
Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.
The Journal of clinical investigation
Ohmura S,Mizuno S,Oishi H,Ku CJ,Hermann M,Hosoya T,Takahashi S,Engel JD
Tue Mar 01 00:00:00 UTC 2016
ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.
The Journal of clinical investigation
Kupz A,Zedler U,Stäber M,Perdomo C,Dorhoi A,Brosch R,Kaufmann SH
Wed Jun 01 00:00:00 UTC 2016
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
The Journal of experimental medicine
Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G
Mon Oct 17 00:00:00 UTC 2016
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
The Journal of experimental medicine
Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C
Mon Aug 22 00:00:00 UTC 2016
Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.
The Journal of experimental medicine
Chopra M,Biehl M,Steinfatt T,Brandl A,Kums J,Amich J,Vaeth M,Kuen J,Holtappels R,Podlech J,Mottok A,Kraus S,Jordán-Garrote AL,Bäuerlein CA,Brede C,Ribechini E,Fick A,Seher A,Polz J,Ottmüller KJ,Baker J,Nishikii H,Ritz M,Mattenheimer K,Schwinn S,Winter T,Schäfer V,Krappmann S,Einsele H,Müller TD,Reddehase MJ,Lutz MB,Männel DN,Berberich-Siebelt F,Wajant H,Beilhack A
Mon Aug 22 00:00:00 UTC 2016
Control of Foxp3 stability through modulation of TET activity.
The Journal of experimental medicine
Yue X,Trifari S,Äijö T,Tsagaratou A,Pastor WA,Zepeda-Martínez JA,Lio CW,Li X,Huang Y,Vijayanand P,Lähdesmäki H,Rao A
Mon Mar 07 00:00:00 UTC 2016
Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals.
Proceedings of the National Academy of Sciences of the United States of America
Ryan PL,Sumaria N,Holland CJ,Bradford CM,Izotova N,Grandjean CL,Jawad AS,Bergmeier LA,Pennington DJ
Tue Dec 13 00:00:00 UTC 2016
Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America
Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC
Tue Aug 16 00:00:00 UTC 2016
Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR.
Proceedings of the National Academy of Sciences of the United States of America
Munson DJ,Egelston CA,Chiotti KE,Parra ZE,Bruno TC,Moore BL,Nakano TA,Simons DL,Jimenez G,Yim JH,Rozanov DV,Falta MT,Fontenot AP,Reynolds PR,Leach SM,Borges VF,Kappler JW,Spellman PT,Lee PP,Slansky JE
Tue Jul 19 00:00:00 UTC 2016
The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.
Proceedings of the National Academy of Sciences of the United States of America
Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR
Tue Mar 15 00:00:00 UTC 2016
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Proceedings of the National Academy of Sciences of the United States of America
Zhang B,Chikuma S,Hori S,Fagarasan S,Honjo T
Tue Jul 26 00:00:00 UTC 2016
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.
Proceedings of the National Academy of Sciences of the United States of America
Gross CC,Schulte-Mecklenbeck A,Rünzi A,Kuhlmann T,Posevitz-Fejfár A,Schwab N,Schneider-Hohendorf T,Herich S,Held K,Konjević M,Hartwig M,Dornmair K,Hohlfeld R,Ziemssen T,Klotz L,Meuth SG,Wiendl H
Tue May 24 00:00:00 UTC 2016
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America
He W,Tan GS,Mullarkey CE,Lee AJ,Lam MM,Krammer F,Henry C,Wilson PC,Ashkar AA,Palese P,Miller MS
Tue Oct 18 00:00:00 UTC 2016
Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
Molecular therapy. Nucleic acids
Romano Ibarra GS,Paul B,Sather BD,Younan PM,Sommer K,Kowalski JP,Hale M,Stoddard B,Jarjour J,Astrakhan A,Kiem HP,Rawlings DJ
Tue Aug 23 00:00:00 UTC 2016
pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.
Molecular therapy. Nucleic acids
Grier AE,Burleigh S,Sahni J,Clough CA,Cardot V,Choe DC,Krutein MC,Rawlings DJ,Jensen MC,Scharenberg AM,Jacoby K
Tue Apr 19 00:00:00 UTC 2016
Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals.
European journal of immunology
Subramaniam S,Aslam A,Misbah SA,Salio M,Cerundolo V,Moody DB,Ogg G
Fri Jan 01 00:00:00 UTC 2016
LZTFL1 Upregulated by All-Trans Retinoic Acid during CD4+ T Cell Activation Enhances IL-5 Production.
Journal of immunology (Baltimore, Md. : 1950)
Jiang H,Promchan K,Lin BR,Lockett S,Chen D,Marshall H,Badralmaa Y,Natarajan V
Mon Feb 01 00:00:00 UTC 2016
The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
Journal of immunology (Baltimore, Md. : 1950)
Tosh KW,Mittereder L,Bonne-Annee S,Hieny S,Nutman TB,Singer SM,Sher A,Jankovic D
Fri Jan 01 00:00:00 UTC 2016
Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Felley LE,Sharma A,Theisen E,Romero-Masters JC,Sauer JD,Gumperz JE
Thu Sep 15 00:00:00 UTC 2016
Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.
Journal of immunology (Baltimore, Md. : 1950)
Chheda ZS,Sharma RK,Jala VR,Luster AD,Haribabu B
Thu Sep 01 00:00:00 UTC 2016
LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling-Dependent Notch Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Verma NK,Fazil MH,Ong ST,Chalasani ML,Low JH,Kottaiswamy A,P P,Kizhakeyil A,Kumar S,Panda AK,Freeley M,Smith SM,Boehm BO,Kelleher D
Fri Jul 01 00:00:00 UTC 2016
The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions.
Journal of immunology (Baltimore, Md. : 1950)
Dimeloe S,Mehling M,Frick C,Loeliger J,Bantug GR,Sauder U,Fischer M,Belle R,Develioglu L,Tay S,Langenkamp A,Hess C
Fri Jan 01 00:00:00 UTC 2016
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Journal of immunology (Baltimore, Md. : 1950)
Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T
Sun May 15 00:00:00 UTC 2016
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950)
Paquin-Proulx D,Gibbs A,Bächle SM,Checa A,Introini A,Leeansyah E,Wheelock CE,Nixon DF,Broliden K,Tjernlund A,Moll M,Sandberg JK
Thu Sep 01 00:00:00 UTC 2016
Acetylation Modulates IL-2 Receptor Signaling in T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuwabara T,Kasai H,Kondo M
Thu Dec 01 00:00:00 UTC 2016
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Journal of immunology (Baltimore, Md. : 1950)
Hu X,Valentin A,Dayton F,Kulkarni V,Alicea C,Rosati M,Chowdhury B,Gautam R,Broderick KE,Sardesai NY,Martin MA,Mullins JI,Pavlakis GN,Felber BK
Tue Nov 15 00:00:00 UTC 2016
A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.
Journal of immunology (Baltimore, Md. : 1950)
Akkaya B,Miozzo P,Holstein AH,Shevach EM,Pierce SK,Akkaya M
Thu Sep 01 00:00:00 UTC 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 UTC 2016
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A
Tue Nov 15 00:00:00 UTC 2016
Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
Journal of immunology (Baltimore, Md. : 1950)
Su KY,Watanabe A,Yeh CH,Kelsoe G,Kuraoka M
Tue Nov 15 00:00:00 UTC 2016
Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wendt E,White GE,Ferry H,Huhn M,Greaves DR,Keshav S
Sun May 01 00:00:00 UTC 2016
HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins.
Journal of immunology (Baltimore, Md. : 1950)
Reches A,Nachmani D,Berhani O,Duev-Cohen A,Shreibman D,Ophir Y,Seliger B,Mandelboim O
Wed Jun 15 00:00:00 UTC 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 UTC 2016
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Nature communications
Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C
Tue Mar 15 00:00:00 UTC 2016
TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles).
Cell death & disease
Xing Y,Cao R,Hu HM
Thu Aug 04 00:00:00 UTC 2016
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
The Journal of biological chemistry
Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H
Fri Nov 04 00:00:00 UTC 2016
CEACAM1 mediates B cell aggregation in central nervous system autoimmunity.
Scientific reports
Rovituso DM,Scheffler L,Wunsch M,Kleinschnitz C,Dörck S,Ulzheimer J,Bayas A,Steinman L,Ergün S,Kuerten S
Wed Jul 20 00:00:00 UTC 2016
All-trans retinoic acid and interferon-α increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors.
Blood cancer journal
Mihara K,Yoshida T,Ishida S,Takei Y,Kitanaka A,Shimoda K,Morishita K,Takihara Y,Ichinohe T
Fri May 13 00:00:00 UTC 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 UTC 2016
Generation and protective efficacy of a cold-adapted attenuated avian H9N2 influenza vaccine.
Scientific reports
Wei Y,Qi L,Gao H,Sun H,Pu J,Sun Y,Liu J
Tue Jul 26 00:00:00 UTC 2016
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.
Scientific reports
Zhang ZQ,Ren SC,Tan Y,Li ZZ,Tang X,Wang TT,Hao DL,Zhao X,Chen HZ,Liu DP
Tue Apr 05 00:00:00 UTC 2016
Staphylococcus aureus-derived factors induce IL-10, IFN-γ and IL-17A-expressing FOXP3+CD161+ T-helper cells in a partly monocyte-dependent manner.
Scientific reports
Björkander S,Hell L,Johansson MA,Forsberg MM,Lasaviciute G,Roos S,Holmlund U,Sverremark-Ekström E
Fri Feb 26 00:00:00 UTC 2016
Staphylococcus aureus-derived factors induce IL-10, IFN-γ and IL-17A-expressing FOXP3+CD161+ T-helper cells in a partly monocyte-dependent manner.
Scientific reports
Björkander S,Hell L,Johansson MA,Forsberg MM,Lasaviciute G,Roos S,Holmlund U,Sverremark-Ekström E
Fri Feb 26 00:00:00 UTC 2016
DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity.
Cell death & disease
Wang Y,Sun H,Wang J,Wang H,Meng L,Xu C,Jin M,Wang B,Zhang Y,Zhang Y,Zhu T
Thu Jul 28 00:00:00 UTC 2016
Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.
Scientific reports
Lee WW,Teo TH,Lum FM,Andiappan AK,Amrun SN,Rénia L,Rötzschke O,Ng LF
Fri Nov 25 00:00:00 UTC 2016
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Scientific reports
Clement M,Pearson JA,Gras S,van den Berg HA,Lissina A,Llewellyn-Lacey S,Willis MD,Dockree T,McLaren JE,Ekeruche-Makinde J,Gostick E,Robertson NP,Rossjohn J,Burrows SR,Price DA,Wong FS,Peakman M,Skowera A,Wooldridge L
Mon Oct 17 00:00:00 UTC 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
Fri Aug 05 00:00:00 UTC 2016
Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells.
The Journal of biological chemistry
Ali RA,Camick C,Wiles K,Walseth TF,Slama JT,Bhattacharya S,Giovannucci DR,Wall KA
Fri Feb 26 00:00:00 UTC 2016
The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.
The Journal of biological chemistry
Lykken EA,Li QJ
Fri Nov 04 00:00:00 UTC 2016
T-cell stimuli independently sum to regulate an inherited clonal division fate.
Nature communications
Marchingo JM,Prevedello G,Kan A,Heinzel S,Hodgkin PD,Duffy KR
Mon Nov 21 00:00:00 UTC 2016
Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner.
Scientific reports
Kim H,Choi MS,Inn KS,Kim BJ
Fri Jul 01 00:00:00 UTC 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
Mon Nov 28 00:00:00 UTC 2016
MicroRNA-491 regulates the proliferation and apoptosis of CD8(+) T cells.
Scientific reports
Yu T,Zuo QF,Gong L,Wang LN,Zou QM,Xiao B
Wed Aug 03 00:00:00 UTC 2016
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
Nature medicine
Tada T,Zhang Y,Koyama T,Tobiume M,Tsunetsugu-Yokota Y,Yamaoka S,Fujita H,Tokunaga K
Tue Dec 01 00:00:00 UTC 2015
A hardwired HIV latency program.
Cell
Razooky BS,Pai A,Aull K,Rouzine IM,Weinberger LS
Thu Feb 26 00:00:00 UTC 2015
The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Immunity
Rapaport AS,Schriewer J,Gilfillan S,Hembrador E,Crump R,Plougastel BF,Wang Y,Le Friec G,Gao J,Cella M,Pircher H,Yokoyama WM,Buller RM,Colonna M
Tue Dec 15 00:00:00 UTC 2015
Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.
Immunity
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Oe T,Wu R,Lavoie A,Walter JE,Notarangelo LD,Al-Herz W,Kilic SS,Ochs HD,Nonoyama S,Durandy A,Meffre E
Tue Nov 17 00:00:00 UTC 2015
Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.
Blood
Geskin LJ,Viragova S,Stolz DB,Fuschiotti P
Thu Apr 30 00:00:00 UTC 2015
Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.
Blood
Leone P,Berardi S,Frassanito MA,Ria R,De Re V,Cicco S,Battaglia S,Ditonno P,Dammacco F,Vacca A,Racanelli V
Thu Sep 17 00:00:00 UTC 2015
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
The Journal of clinical investigation
Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L
Tue Sep 01 00:00:00 UTC 2015
Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.
The Journal of clinical investigation
Quast I,Keller CW,Maurer MA,Giddens JP,Tackenberg B,Wang LX,Münz C,Nimmerjahn F,Dalakas MC,Lünemann JD
Mon Nov 02 00:00:00 UTC 2015
Follicular helper T cell signature in type 1 diabetes.
The Journal of clinical investigation
Kenefeck R,Wang CJ,Kapadi T,Wardzinski L,Attridge K,Clough LE,Heuts F,Kogimtzis A,Patel S,Rosenthal M,Ono M,Sansom DM,Narendran P,Walker LS
Thu Jan 01 00:00:00 UTC 2015
Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.
The Journal of clinical investigation
McCracken MN,Vatakis DN,Dixit D,McLaughlin J,Zack JA,Witte ON
Fri May 01 00:00:00 UTC 2015
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
The Journal of clinical investigation
Chauvin JM,Pagliano O,Fourcade J,Sun Z,Wang H,Sander C,Kirkwood JM,Chen TH,Maurer M,Korman AJ,Zarour HM
Fri May 01 00:00:00 UTC 2015
Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.
The Journal of experimental medicine
Jenkins MR,Rudd-Schmidt JA,Lopez JA,Ramsbottom KM,Mannering SI,Andrews DM,Voskoboinik I,Trapani JA
Mon Mar 09 00:00:00 UTC 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
Mon May 04 00:00:00 UTC 2015
Bee venom processes human skin lipids for presentation by CD1a.
The Journal of experimental medicine
Bourgeois EA,Subramaniam S,Cheng TY,De Jong A,Layre E,Ly D,Salimi M,Legaspi A,Modlin RL,Salio M,Cerundolo V,Moody DB,Ogg G
Mon Feb 09 00:00:00 UTC 2015
Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.
The Journal of experimental medicine
Frye M,Dierkes M,Küppers V,Vockel M,Tomm J,Zeuschner D,Rossaint J,Zarbock A,Koh GY,Peters K,Nottebaum AF,Vestweber D
Mon Dec 14 00:00:00 UTC 2015
The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Evans JH,Crespo ÂC,Strominger JL
Tue Oct 27 00:00:00 UTC 2015
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Liu J,Yuan Y,Chen W,Putra J,Suriawinata AA,Schenk AD,Miller HE,Guleria I,Barth RJ,Huang YH,Wang L
Tue May 26 00:00:00 UTC 2015
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
Proceedings of the National Academy of Sciences of the United States of America
Hammitzsch A,Tallant C,Fedorov O,O'Mahony A,Brennan PE,Hay DA,Martinez FO,Al-Mossawi MH,de Wit J,Vecellio M,Wells C,Wordsworth P,Müller S,Knapp S,Bowness P
Tue Aug 25 00:00:00 UTC 2015
TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.
Proceedings of the National Academy of Sciences of the United States of America
Sperandio S,Barat C,Cabrita MA,Gargaun A,Berezovski MV,Tremblay MJ,de Belle I
Tue Jun 30 00:00:00 UTC 2015
Myosin VI regulates gene pairing and transcriptional pause release in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Zorca CE,Kim LK,Kim YJ,Krause MR,Zenklusen D,Spilianakis CG,Flavell RA
Tue Mar 31 00:00:00 UTC 2015
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.
Aging cell
van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM
Thu Oct 01 00:00:00 UTC 2015
Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly.
Molecular therapy. Nucleic acids
Khamaikawin W,Saoin S,Nangola S,Chupradit K,Sakkhachornphop S,Hadpech S,Onlamoon N,Ansari AA,Byrareddy SN,Boulanger P,Hong SS,Torbett BE,Tayapiwatana C
Tue Aug 25 00:00:00 UTC 2015
Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses.
Cancer gene therapy
Kuramitsu S,Ohno M,Ohka F,Shiina S,Yamamichi A,Kato A,Tanahashi K,Motomura K,Kondo G,Kurimoto M,Senga T,Wakabayashi T,Natsume A
Thu Oct 01 00:00:00 UTC 2015
Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.
Stem cells (Dayton, Ohio)
Pan QZ,Pan K,Wang QJ,Weng DS,Zhao JJ,Zheng HX,Zhang XF,Jiang SS,Lv L,Tang Y,Li YQ,He J,Liu Q,Chen CL,Zhang HX,Xia JC
Sun Feb 01 00:00:00 UTC 2015
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.
Stem cells (Dayton, Ohio)
Amarnath S,Foley JE,Farthing DE,Gress RE,Laurence A,Eckhaus MA,Métais JY,Rose JJ,Hakim FT,Felizardo TC,Cheng AV,Robey PG,Stroncek DE,Sabatino M,Battiwalla M,Ito S,Fowler DH,Barrett AJ
Wed Apr 01 00:00:00 UTC 2015
T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells.
Clinical and experimental immunology
Tan MP,Gerry AB,Brewer JE,Melchiori L,Bridgeman JS,Bennett AD,Pumphrey NJ,Jakobsen BK,Price DA,Ladell K,Sewell AK
Fri May 01 00:00:00 UTC 2015
MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development.
Journal of immunology (Baltimore, Md. : 1950)
Sakaguchi S,Hainberger D,Tizian C,Tanaka H,Okuda T,Taniuchi I,Ellmeier W
Tue Sep 15 00:00:00 UTC 2015
UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.
Journal of immunology (Baltimore, Md. : 1950)
Iizuka Y,Cichocki F,Sieben A,Sforza F,Karim R,Coughlin K,Isaksson Vogel R,Gavioli R,McCullar V,Lenvik T,Lee M,Miller J,Bazzaro M
Sun Nov 15 00:00:00 UTC 2015
CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Leitner J,Herndler-Brandstetter D,Zlabinger GJ,Grubeck-Loebenstein B,Steinberger P
Wed Jul 15 00:00:00 UTC 2015
Relative expression levels of the HLA class-I proteins in normal and HIV-infected cells.
Journal of immunology (Baltimore, Md. : 1950)
Apps R,Meng Z,Del Prete GQ,Lifson JD,Zhou M,Carrington M
Wed Apr 15 00:00:00 UTC 2015
5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p.
Journal of immunology (Baltimore, Md. : 1950)
Busch S,Auth E,Scholl F,Huenecke S,Koehl U,Suess B,Steinhilber D
Sun Feb 15 00:00:00 UTC 2015
Id3 Controls Cell Death of 2B4+ Virus-Specific CD8+ T Cells in Chronic Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Menner AJ,Rauch KS,Aichele P,Pircher H,Schachtrup C,Schachtrup K
Tue Sep 01 00:00:00 UTC 2015
Eomesodermin Expression in CD4+ T Cells Restricts Peripheral Foxp3 Induction.
Journal of immunology (Baltimore, Md. : 1950)
Lupar E,Brack M,Garnier L,Laffont S,Rauch KS,Schachtrup K,Arnold SJ,Guéry JC,Izcue A
Sun Nov 15 00:00:00 UTC 2015
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
Journal of immunology (Baltimore, Md. : 1950)
Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D
Tue Sep 15 00:00:00 UTC 2015
Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
Journal of immunology (Baltimore, Md. : 1950)
Nielsen CM,White MJ,Bottomley C,Lusa C,Rodríguez-Galán A,Turner SE,Goodier MR,Riley EM
Fri May 15 00:00:00 UTC 2015
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
Journal of immunology (Baltimore, Md. : 1950)
Hsu P,Santner-Nanan B,Hu M,Skarratt K,Lee CH,Stormon M,Wong M,Fuller SJ,Nanan R
Thu Oct 15 00:00:00 UTC 2015
IL-4-Producing Dendritic Cells Induced during Schistosoma japonica Infection Promote Th2 Cells via IL-4-Dependent Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma YL,Huang FJ,Cong L,Gong WC,Bai HM,Li J,Chen CX,Zhou NY,Jiang XL,Yin L,Chen XP
Thu Oct 15 00:00:00 UTC 2015
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.
Journal of immunology (Baltimore, Md. : 1950)
Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT
Sun Mar 15 00:00:00 UTC 2015
Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Salmond RJ,Brownlie RJ,Meyuhas O,Zamoyska R
Sun Nov 15 00:00:00 UTC 2015
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells.
Journal of immunology (Baltimore, Md. : 1950)
Forslund E,Sohlberg E,Enqvist M,Olofsson PE,Malmberg KJ,Önfelt B
Thu Oct 01 00:00:00 UTC 2015
CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients.
Journal of immunology (Baltimore, Md. : 1950)
Kaltenmeier C,Gawanbacht A,Beyer T,Lindner S,Trzaska T,van der Merwe JA,Härter G,Grüner B,Fabricius D,Lotfi R,Schwarz K,Schütz C,Hönig M,Schulz A,Kern P,Bommer M,Schrezenmeier H,Kirchhoff F,Jahrsdörfer B
Wed Apr 15 00:00:00 UTC 2015
ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
Journal of immunology (Baltimore, Md. : 1950)
Buckley MW,Trampont PC,Arandjelovic S,Fond AM,Juncadella IJ,Ravichandran KS
Sun Feb 15 00:00:00 UTC 2015
Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
Journal of immunology (Baltimore, Md. : 1950)
Liu Y,Bezverbnaya K,Zhao T,Parsons MJ,Shi M,Treanor B,Ehrhardt GR
Mon Jun 15 00:00:00 UTC 2015
Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.
Journal of immunology (Baltimore, Md. : 1950)
Kim MT,Richer MJ,Gross BP,Norian LA,Badovinac VP,Harty JT
Sun Nov 01 00:00:00 UTC 2015
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bornancin F,Renner F,Touil R,Sic H,Kolb Y,Touil-Allaoui I,Rush JS,Smith PA,Bigaud M,Junker-Walker U,Burkhart C,Dawson J,Niwa S,Katopodis A,Nuesslein-Hildesheim B,Weckbecker G,Zenke G,Kinzel B,Traggiai E,Brenner D,Brüstle A,St Paul M,Zamurovic N,McCoy KD,Rolink A,Régnier CH,Mak TW,Ohashi PS,Patel DD,Calzascia T
Wed Apr 15 00:00:00 UTC 2015
Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.
Journal of community health
Vamos CA,Calvo AE,Daley EM,Giuliano AR,López Castillo H
Tue Dec 01 00:00:00 UTC 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
Fri Feb 20 00:00:00 UTC 2015
Batf is important for IL-4 expression in T follicular helper cells.
Nature communications
Sahoo A,Alekseev A,Tanaka K,Obertas L,Lerman B,Haymaker C,Clise-Dwyer K,McMurray JS,Nurieva R
Mon Aug 17 00:00:00 UTC 2015
Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production.
Scientific reports
Daszkiewicz L,Vázquez-Mateo C,Rackov G,Ballesteros-Tato A,Weber K,Madrigal-Avilés A,Di Pilato M,Fotedar A,Fotedar R,Flores JM,Esteban M,Martínez-A C,Balomenos D
Fri Jan 09 00:00:00 UTC 2015
MicroRNA-155 Reinforces HIV Latency.
The Journal of biological chemistry
Ruelas DS,Chan JK,Oh E,Heidersbach AJ,Hebbeler AM,Chavez L,Verdin E,Rape M,Greene WC
Fri May 29 00:00:00 UTC 2015
Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo.
Nature communications
Chen X,Tang S,Zheng JS,Zhao R,Wang ZP,Shao W,Chang HN,Cheng JY,Zhao H,Liu L,Qi H
Tue May 26 00:00:00 UTC 2015
IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.
Scientific reports
Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J
Tue Oct 06 00:00:00 UTC 2015
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors.
Journal for immunotherapy of cancer
Hammill JA,VanSeggelen H,Helsen CW,Denisova GF,Evelegh C,Tantalo DG,Bassett JD,Bramson JL
200-02 was used in Cell Culture to investigate the production of chimeric antigen receptors with novel antigen binding attributes.
Thu Dec 17 00:00:00 UTC 2015
The brain antigen-specific B cell response correlates with glatiramer acetate responsiveness in relapsing-remitting multiple sclerosis patients.
Scientific reports
Rovituso DM,Duffy CE,Schroeter M,Kaiser CC,Kleinschnitz C,Bayas A,Elsner R,Kuerten S
Mon Sep 21 00:00:00 UTC 2015
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
PloS one
Bremser A,Brack M,Izcue A
200-02 was used in Cell Culture to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.
Tue May 24 00:00:00 UTC 2016
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
The Journal of biological chemistry
Nata T,Basheer A,Cocchi F,van Besien R,Massoud R,Jacobson S,Azimi N,Tagaya Y
Fri Sep 11 00:00:00 UTC 2015
Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues.
Scientific reports
Scoville SD,Keller KA,Cheng S,Zhang M,Zhang X,Caligiuri MA,Freud AG
Thu Jul 30 00:00:00 UTC 2015
High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.
Scientific reports
Pink D,Luhrs KA,Zhou L,Schulte W,Chase J,Frosch C,Haberl U,Nguyen V,Roy AI,Lewis JD,Zijlstra A,Parseghian MH
Thu Oct 29 00:00:00 UTC 2015
High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.
Scientific reports
Pink D,Luhrs KA,Zhou L,Schulte W,Chase J,Frosch C,Haberl U,Nguyen V,Roy AI,Lewis JD,Zijlstra A,Parseghian MH
Thu Oct 29 00:00:00 UTC 2015
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function.
Scientific reports
Ni F,Guo C,Sun R,Fu B,Yang Y,Wu L,Ren S,Tian Z,Wei H
Fri Apr 24 00:00:00 UTC 2015
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function.
Scientific reports
Ni F,Guo C,Sun R,Fu B,Yang Y,Wu L,Ren S,Tian Z,Wei H
Fri Apr 24 00:00:00 UTC 2015
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Cell
Li X,Liang Y,LeBlanc M,Benner C,Zheng Y
Thu Aug 14 00:00:00 UTC 2014
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity.
Cell
Bournazos S,Klein F,Pietzsch J,Seaman MS,Nussenzweig MC,Ravetch JV
Thu Sep 11 00:00:00 UTC 2014
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 UTC 2014
Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation.
Immunity
Hong C,Luckey MA,Ligons DL,Waickman AT,Park JY,Kim GY,Keller HR,Etzensperger R,Tai X,Lazarevic V,Feigenbaum L,Catalfamo M,Walsh ST,Park JH
Thu Jun 19 00:00:00 UTC 2014
Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.
Blood
Speak AO,Te Vruchte D,Davis LC,Morgan AJ,Smith DA,Yanjanin NM,Simmons L,Hartung R,Runz H,Mengel E,Beck M,Imrie J,Jacklin E,Wraith JE,Hendriksz C,Lachmann R,Cognet C,Sidhu R,Fujiwara H,Ory DS,Galione A,Porter FD,Vivier E,Platt FM
Thu Jan 02 00:00:00 UTC 2014
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53.
Blood
Fecteau JF,Corral LG,Ghia EM,Gaidarova S,Futalan D,Bharati IS,Cathers B,Schwaederlé M,Cui B,Lopez-Girona A,Messmer D,Kipps TJ
Thu Sep 04 00:00:00 UTC 2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.
Blood
Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK
Thu Feb 20 00:00:00 UTC 2014
p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells.
The Journal of clinical investigation
Henson SM,Lanna A,Riddell NE,Franzese O,Macaulay R,Griffiths SJ,Puleston DJ,Watson AS,Simon AK,Tooze SA,Akbar AN
Mon Sep 01 00:00:00 UTC 2014
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
The Journal of experimental medicine
Weber GF,Chousterman BG,Hilgendorf I,Robbins CS,Theurl I,Gerhardt LM,Iwamoto Y,Quach TD,Ali M,Chen JW,Rothstein TL,Nahrendorf M,Weissleder R,Swirski FK
Mon Jun 02 00:00:00 UTC 2014
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
The Journal of experimental medicine
Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT
Mon Jun 02 00:00:00 UTC 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
Fri Aug 01 00:00:00 UTC 2014
Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fisher JP,Yan M,Heuijerjans J,Carter L,Abolhassani A,Frosch J,Wallace R,Flutter B,Capsomidis A,Hubank M,Klein N,Callard R,Gustafsson K,Anderson J
200-02 was used in Cell Culture to demonstrate that polyclonal-expanded populations of γδ T cells are capable of both antibody-dependent and -independent effector functions in neuroblastoma.
Sat Nov 15 00:00:00 UTC 2014
Stretched cell cycle model for proliferating lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Dowling MR,Kan A,Heinzel S,Zhou JH,Marchingo JM,Wellard CJ,Markham JF,Hodgkin PD
Tue Apr 29 00:00:00 UTC 2014
TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Donatelli SS,Zhou JM,Gilvary DL,Eksioglu EA,Chen X,Cress WD,Haura EB,Schabath MB,Coppola D,Wei S,Djeu JY
Tue Mar 18 00:00:00 UTC 2014
Essential role for autophagy during invariant NKT cell development.
Proceedings of the National Academy of Sciences of the United States of America
Salio M,Puleston DJ,Mathan TS,Shepherd D,Stranks AJ,Adamopoulou E,Veerapen N,Besra GS,Hollander GA,Simon AK,Cerundolo V
Tue Dec 30 00:00:00 UTC 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
Tue Oct 14 00:00:00 UTC 2014
Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy.
British journal of cancer
Oppenheim DE,Spreafico R,Etuk A,Malone D,Amofah E,Peña-Murillo C,Murray T,McLaughlin L,Choi BS,Allan S,Belousov A,Passioukov A,Gerdes C,Umaña P,Farzaneh F,Ross P
Tue Mar 04 00:00:00 UTC 2014
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
Mucosal immunology
Yu X,Pappu R,Ramirez-Carrozzi V,Ota N,Caplazi P,Zhang J,Yan D,Xu M,Lee WP,Grogan JL
Thu May 01 00:00:00 UTC 2014
Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.
Immunology and cell biology
Ghamlouch H,Ouled-Haddou H,Guyart A,Regnier A,Trudel S,Claisse JF,Fuentes V,Royer B,Marolleau JP,Gubler B
Fri Aug 01 00:00:00 UTC 2014
TLR ligands stimulation protects MSC from NK killing.
Stem cells (Dayton, Ohio)
Giuliani M,Bennaceur-Griscelli A,Nanbakhsh A,Oudrhiri N,Chouaib S,Azzarone B,Durrbach A,Lataillade JJ
Wed Jan 01 00:00:00 UTC 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
Tue Jul 15 00:00:00 UTC 2014
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kim KD,Srikanth S,Tan YV,Yee MK,Jew M,Damoiseaux R,Jung ME,Shimizu S,An DS,Ribalet B,Waschek JA,Gwack Y
Wed Jan 01 00:00:00 UTC 2014
Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.
Journal of immunology (Baltimore, Md. : 1950)
Arneja A,Johnson H,Gabrovsek L,Lauffenburger DA,White FM
Wed Jan 01 00:00:00 UTC 2014
The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.
Journal of immunology (Baltimore, Md. : 1950)
Uhlenbrock F,Hagemann-Jensen M,Kehlet S,Andresen L,Pastorekova S,Skov S
Fri Aug 15 00:00:00 UTC 2014
A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Wickström SL,Öberg L,Kärre K,Johansson MH
Sat Feb 15 00:00:00 UTC 2014
B cell-intrinsic MyD88 signaling is essential for IgE responses in lungs exposed to pollen allergens.
Journal of immunology (Baltimore, Md. : 1950)
Matsushita K,Yoshimoto T
Mon Dec 15 00:00:00 UTC 2014
SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.
Journal of immunology (Baltimore, Md. : 1950)
Katz G,Krummey SM,Larsen SE,Stinson JR,Snow AL
Thu May 01 00:00:00 UTC 2014
Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity.
Journal of immunology (Baltimore, Md. : 1950)
Lee J,Walsh MC,Hoehn KL,James DE,Wherry EJ,Choi Y
Tue Apr 01 00:00:00 UTC 2014
Involvement of Notch in activation and effector functions of γδ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Gogoi D,Dar AA,Chiplunkar SV
Sat Mar 01 00:00:00 UTC 2014
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C
Wed Jan 01 00:00:00 UTC 2014
Tumor-derived α-fetoprotein impairs the differentiation and T cell stimulatory activity of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Pardee AD,Shi J,Butterfield LH
Mon Dec 01 00:00:00 UTC 2014
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B
Sat Mar 15 00:00:00 UTC 2014
Th17 cells demonstrate stable cytokine production in a proallergic environment.
Journal of immunology (Baltimore, Md. : 1950)
Glosson-Byers NL,Sehra S,Stritesky GL,Yu Q,Awe O,Pham D,Bruns HA,Kaplan MH
Mon Sep 15 00:00:00 UTC 2014
Identification and clinical relevance of naturally occurring human CD8+HLA-DR+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Arruvito L,Payaslián F,Baz P,Podhorzer A,Billordo A,Pandolfi J,Semeniuk G,Arribalzaga E,Fainboim L
Sat Nov 01 00:00:00 UTC 2014
The two human CXCR4 isoforms display different HIV receptor activities: consequences for the emergence of X4 strains.
Journal of immunology (Baltimore, Md. : 1950)
Duquenne C,Psomas C,Gimenez S,Guigues A,Carles MJ,Barbuat C,Lavigne JP,Sotto A,Reynes J,Guglielmi P,Mettling C,François V,Corbeau P
Wed Oct 15 00:00:00 UTC 2014
IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Matta BM,Lott JM,Mathews LR,Liu Q,Rosborough BR,Blazar BR,Turnquist HR
Wed Oct 15 00:00:00 UTC 2014
Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.
The Journal of biological chemistry
Ong ST,Freeley M,Skubis-Zegadło J,Fazil MH,Kelleher D,Fresser F,Baier G,Verma NK,Long A
Fri Jul 11 00:00:00 UTC 2014
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Nature
Kane M,Yadav SS,Bitzegeio J,Kutluay SB,Zang T,Wilson SJ,Schoggins JW,Rice CM,Yamashita M,Hatziioannou T,Bieniasz PD
Thu Oct 24 00:00:00 UTC 2013
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
Immunity
Carrera Silva EA,Chan PY,Joannas L,Errasti AE,Gagliani N,Bosurgi L,Jabbour M,Perry A,Smith-Chakmakova F,Mucida D,Cheroutre H,Burstyn-Cohen T,Leighton JA,Lemke G,Ghosh S,Rothlin CV
Thu Jul 25 00:00:00 UTC 2013
The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.
Blood
Das R,Bassiri H,Guan P,Wiener S,Banerjee PP,Zhong MC,Veillette A,Orange JS,Nichols KE
Thu Apr 25 00:00:00 UTC 2013
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Blood
May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T
Thu Apr 18 00:00:00 UTC 2013
Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.
Blood
Miyazaki Y,Fujiwara H,Asai H,Ochi F,Ochi T,Azuma T,Ishida T,Okamoto S,Mineno J,Kuzushima K,Shiku H,Yasukawa M
Thu Jun 13 00:00:00 UTC 2013
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
Blood
Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C
Thu Jan 24 00:00:00 UTC 2013
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.
The Journal of experimental medicine
Gasteiger G,Hemmers S,Firth MA,Le Floc'h A,Huse M,Sun JC,Rudensky AY
Mon Jun 03 00:00:00 UTC 2013
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.
The Journal of experimental medicine
Kotlarz D,Ziętara N,Uzel G,Weidemann T,Braun CJ,Diestelhorst J,Krawitz PM,Robinson PN,Hecht J,Puchałka J,Gertz EM,Schäffer AA,Lawrence MG,Kardava L,Pfeifer D,Baumann U,Pfister ED,Hanson EP,Schambach A,Jacobs R,Kreipe H,Moir S,Milner JD,Schwille P,Mundlos S,Klein C
Mon Mar 11 00:00:00 UTC 2013
BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid.
The Journal of experimental medicine
Wang C,Thangamani S,Kim M,Gu BH,Lee JH,Taparowsky EJ,Kim CH
Mon Mar 11 00:00:00 UTC 2013
ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death.
Autophagy
Garg AD,Dudek AM,Ferreira GB,Verfaillie T,Vandenabeele P,Krysko DV,Mathieu C,Agostinis P
200-02 was used in Cell Culture to unravel a role for ROS-induced autophagy in weakening functional interaction between dying cancer cells and the immune system.
Sun Sep 01 00:00:00 UTC 2013
Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections.
Proceedings of the National Academy of Sciences of the United States of America
Kupz A,Scott TA,Belz GT,Andrews DM,Greyer M,Lew AM,Brooks AG,Smyth MJ,Curtiss R,Bedoui S,Strugnell RA
Tue Feb 05 00:00:00 UTC 2013
Lymphocyte-derived ACh regulates local innate but not adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America
Reardon C,Duncan GS,Brüstle A,Brenner D,Tusche MW,Olofsson PS,Rosas-Ballina M,Tracey KJ,Mak TW
Tue Jan 22 00:00:00 UTC 2013
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
Mucosal immunology
Barnes MJ,Griseri T,Johnson AM,Young W,Powrie F,Izcue A
Fri Mar 01 00:00:00 UTC 2013
Technical advance. Measurement of iNKT cell responses at the single-cell level against rare HIV-1-infected dendritic cells in a mixed culture.
Journal of leukocyte biology
Andersson SK,Paquin-Proulx D,Kroll M,Sandberg JK,Moll M
Fri Mar 01 00:00:00 UTC 2013
An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.
Stem cells (Dayton, Ohio)
Okita K,Yamakawa T,Matsumura Y,Sato Y,Amano N,Watanabe A,Goshima N,Yamanaka S
Fri Mar 01 00:00:00 UTC 2013
An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.
Stem cells (Dayton, Ohio)
Okita K,Yamakawa T,Matsumura Y,Sato Y,Amano N,Watanabe A,Goshima N,Yamanaka S
Fri Mar 01 00:00:00 UTC 2013
Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor.
Journal of immunology (Baltimore, Md. : 1950)
López-Soto A,Huergo-Zapico L,Galván JA,Rodrigo L,de Herreros AG,Astudillo A,Gonzalez S
Mon Apr 15 00:00:00 UTC 2013
T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sandy AR,Chung J,Toubai T,Shan GT,Tran IT,Friedman A,Blackwell TS,Reddy P,King PD,Maillard I
Sat Jun 01 00:00:00 UTC 2013
Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.
Journal of immunology (Baltimore, Md. : 1950)
Lopez JA,Jenkins MR,Rudd-Schmidt JA,Brennan AJ,Danne JC,Mannering SI,Trapani JA,Voskoboinik I
Sun Sep 01 00:00:00 UTC 2013
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM
Sat Jun 01 00:00:00 UTC 2013
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH
Mon Jul 15 00:00:00 UTC 2013
Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NE,Bashir Z,Vossenkämper A,Hedin CR,Giles EM,Bhattacharjee S,Brown SG,Sanders TJ,Whelan K,MacDonald TT,Lindsay JO,Stagg AJ
Sun Sep 01 00:00:00 UTC 2013
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Yu J,Du W,Yan F,Wang Y,Li H,Cao S,Yu W,Shen C,Liu J,Ren X
Mon Apr 01 00:00:00 UTC 2013
CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.
Journal of immunology (Baltimore, Md. : 1950)
Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G
Sun Dec 01 00:00:00 UTC 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
Mon Apr 01 00:00:00 UTC 2013
Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity.
Journal of immunology (Baltimore, Md. : 1950)
Ankri C,Shamalov K,Horovitz-Fried M,Mauer S,Cohen CJ
Tue Oct 15 00:00:00 UTC 2013
A distinct subpopulation of human NK cells restricts B cell transformation by EBV.
Journal of immunology (Baltimore, Md. : 1950)
Lünemann A,Vanoaica LD,Azzi T,Nadal D,Münz C
Fri Nov 15 00:00:00 UTC 2013
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
Journal of immunology (Baltimore, Md. : 1950)
Ding BB,Bi E,Chen H,Yu JJ,Ye BH
Fri Feb 15 00:00:00 UTC 2013
Characterization of cell seeding and specific capture of B cells in microbubble well arrays.
Biomedical microdevices
Jones MC,Kobie JJ,Delouise LA
200-02 was used in Cell Culture to investigate the development of microbubble well array technology for sorting antigen-specific B-cells.
Sat Jun 01 00:00:00 UTC 2013
MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells.
Cell death & disease
Liu X,Chen Q,Yan J,Wang Y,Zhu C,Chen C,Zhao X,Xu M,Sun Q,Deng R,Zhang H,Qu Y,Huang J,Jiang B,Yu J
Thu Nov 21 00:00:00 UTC 2013
The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes.
Oncoimmunology
Carlson LM,De Geer A,Sveinbjørnsson B,Orrego A,Martinsson T,Kogner P,Levitskaya J
200-02 was used in Cell Culture to support the hypothesis that CD8(+) T cells are specifically activated within the neuroblastoma microenvironment.
Fri Mar 01 00:00:00 UTC 2013
The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis.
Journal of translational medicine
Santos JM,Bárcia RN,Simões SI,Gaspar MM,Calado S,Agua-Doce A,Almeida SC,Almeida J,Filipe M,Teixeira M,Martins JP,Graça L,Cruz ME,Cruz P,Cruz H
Thu Jan 17 00:00:00 UTC 2013
Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation- A Short Protocol.
Bio-protocol
Clarke EV,Benoit ME,Tenner AJ
200-02 was used in Cell Culture to outline human blood monocyte isolation with counterflow elutriation.
Thu Dec 05 00:00:00 UTC 2013
Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals.
PloS one
Du W,Shen YW,Lee WH,Wang D,Paz S,Kandeel F,Liu CP
Mon Jul 29 00:00:00 UTC 2013
Natural killer cell cytokine response to M. bovis BCG Is associated with inhibited proliferation, increased apoptosis and ultimate depletion of NKp44(+)CD56(bright) cells.
PloS one
Portevin D,Young D
Wed Mar 05 00:00:00 UTC 2014
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
The Journal of biological chemistry
Li C,Ebert PJ,Li QJ
Fri Jun 28 00:00:00 UTC 2013
Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma.
PloS one
Zhang QB,Sun HC,Zhang KZ,Jia QA,Bu Y,Wang M,Chai ZT,Zhang QB,Wang WQ,Kong LQ,Zhu XD,Lu L,Wu WZ,Wang L,Tang ZY
Mon Aug 05 00:00:00 UTC 2013
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Blood
Zocchi MR,Catellani S,Canevali P,Tavella S,Garuti A,Villaggio B,Zunino A,Gobbi M,Fraternali-Orcioni G,Kunkl A,Ravetti JL,Boero S,Musso A,Poggi A
Thu Feb 09 00:00:00 UTC 2012
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma.
Blood
Cedeno-Laurent F,Watanabe R,Teague JE,Kupper TS,Clark RA,Dimitroff CJ
Thu Apr 12 00:00:00 UTC 2012
Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD.
Blood
Sawamukai N,Satake A,Schmidt AM,Lamborn IT,Ojha P,Tanaka Y,Kambayashi T
Thu Jun 07 00:00:00 UTC 2012
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity.
Blood
Ndhlovu LC,Lopez-Vergès S,Barbour JD,Jones RB,Jha AR,Long BR,Schoeffler EC,Fujita T,Nixon DF,Lanier LL
Thu Apr 19 00:00:00 UTC 2012
Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).
Blood
Couzi L,Pitard V,Sicard X,Garrigue I,Hawchar O,Merville P,Moreau JF,Déchanet-Merville J
Thu Feb 09 00:00:00 UTC 2012
Mast cells play a protumorigenic role in primary cutaneous lymphoma.
Blood
Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K
Thu Sep 06 00:00:00 UTC 2012
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.
Blood
Kim YC,Bhairavabhotla R,Yoon J,Golding A,Thornton AM,Tran DQ,Shevach EM
Thu Mar 22 00:00:00 UTC 2012
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.
The Journal of clinical investigation
Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS
Fri Jun 01 00:00:00 UTC 2012
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.
The Journal of clinical investigation
Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS
Fri Jun 01 00:00:00 UTC 2012
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation
Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW
Sat Dec 01 00:00:00 UTC 2012
Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ("FILS syndrome").
The Journal of experimental medicine
Pachlopnik Schmid J,Lemoine R,Nehme N,Cormier-Daire V,Revy P,Debeurme F,Debré M,Nitschke P,Bole-Feysot C,Legeai-Mallet L,Lim A,de Villartay JP,Picard C,Durandy A,Fischer A,de Saint Basile G
Mon Dec 17 00:00:00 UTC 2012
Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
The Journal of experimental medicine
Snow AL,Xiao W,Stinson JR,Lu W,Chaigne-Delalande B,Zheng L,Pittaluga S,Matthews HF,Schmitz R,Jhavar S,Kuchen S,Kardava L,Wang W,Lamborn IT,Jing H,Raffeld M,Moir S,Fleisher TA,Staudt LM,Su HC,Lenardo MJ
Mon Nov 19 00:00:00 UTC 2012
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
The Journal of experimental medicine
Weiss JM,Bilate AM,Gobert M,Ding Y,Curotto de Lafaille MA,Parkhurst CN,Xiong H,Dolpady J,Frey AB,Ruocco MG,Yang Y,Floess S,Huehn J,Oh S,Li MO,Niec RE,Rudensky AY,Dustin ML,Littman DR,Lafaille JJ
Mon Sep 24 00:00:00 UTC 2012
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Proceedings of the National Academy of Sciences of the United States of America
Benson MJ,Aijö T,Chang X,Gagnon J,Pape UJ,Anantharaman V,Aravind L,Pursiheimo JP,Oberdoerffer S,Liu XS,Lahesmaa R,Lähdesmäki H,Rao A
Tue Oct 02 00:00:00 UTC 2012
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.
Proceedings of the National Academy of Sciences of the United States of America
Ostrov DA,Grant BJ,Pompeu YA,Sidney J,Harndahl M,Southwood S,Oseroff C,Lu S,Jakoncic J,de Oliveira CA,Yang L,Mei H,Shi L,Shabanowitz J,English AM,Wriston A,Lucas A,Phillips E,Mallal S,Grey HM,Sette A,Hunt DF,Buus S,Peters B
Tue Jun 19 00:00:00 UTC 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 UTC 2012
Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.
British journal of cancer
De Giovanni C,Nicoletti G,Landuzzi L,Romani F,Croci S,Palladini A,Murgo A,Antognoli A,Ianzano ML,Stivani V,Grosso V,Iezzi M,Stramucci L,Barbieri E,Lemoli RM,Nanni P,Lollini PL
Tue Oct 09 00:00:00 UTC 2012
Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.
British journal of cancer
De Giovanni C,Nicoletti G,Landuzzi L,Romani F,Croci S,Palladini A,Murgo A,Antognoli A,Ianzano ML,Stivani V,Grosso V,Iezzi M,Stramucci L,Barbieri E,Lemoli RM,Nanni P,Lollini PL
Tue Oct 09 00:00:00 UTC 2012
Relatively low level of antigen-specific monocytes detected in blood from untreated tuberculosis patients using CD4+ T-cell receptor tetramers.
PLoS pathogens
Huang Y,Huang Y,Fang Y,Wang J,Li Y,Wang N,Zhang J,Gao M,Huang L,Yang F,Wang C,Lin S,Yao Y,Ren L,Chen Y,Du X,Xie D,Wu R,Zhang K,Jiang L,Yu X,Lai X
Fri Apr 19 00:00:00 UTC 2013
Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD
Sun Apr 01 00:00:00 UTC 2012
Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.
Arthritis research & therapy
Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE
Wed May 23 00:00:00 UTC 2012
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
Journal of molecular medicine (Berlin, Germany)
Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL
Wed Feb 01 00:00:00 UTC 2012
Crosstalk between human IgG isotypes and murine effector cells.
Journal of immunology (Baltimore, Md. : 1950)
Overdijk MB,Verploegen S,Ortiz Buijsse A,Vink T,Leusen JH,Bleeker WK,Parren PW
Mon Oct 01 00:00:00 UTC 2012
Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tkach M,Coria L,Rosemblit C,Rivas MA,Proietti CJ,Díaz Flaqué MC,Beguelin W,Frahm I,Charreau EH,Cassataro J,Elizalde PV,Schillaci R
Wed Aug 01 00:00:00 UTC 2012
Expression of Helios in peripherally induced Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Gottschalk RA,Corse E,Allison JP
Wed Feb 01 00:00:00 UTC 2012
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
Journal of immunology (Baltimore, Md. : 1950)
Hervas-Stubbs S,Mancheño U,Riezu-Boj JI,Larraga A,Ochoa MC,Alignani D,Alfaro C,Morales-Kastresana A,Gonzalez I,Larrea E,Pircher H,Le Bon A,Lopez-Picazo JM,Martín-Algarra S,Prieto J,Melero I
Mon Oct 01 00:00:00 UTC 2012
TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity.
Journal of immunology (Baltimore, Md. : 1950)
Pasetto A,Frelin L,Aleman S,Holmström F,Brass A,Ahlén G,Brenndörfer ED,Lohmann V,Bartenschlager R,Sällberg M,Bertoletti A,Chen M
Thu Nov 01 00:00:00 UTC 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 UTC 2012
Primary MHC-class II(+) cells are necessary to promote resting Vδ2 cell expansion in response to (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate and isopentenyl pyrophosphate.
Journal of immunology (Baltimore, Md. : 1950)
Soriano-Sarabia N,Sandvold H,Jomaa H,Kubin T,Bein G,Hackstein H
Sat Dec 01 00:00:00 UTC 2012
L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Freeley M,O'Dowd F,Paul T,Kashanin D,Davies A,Kelleher D,Long A
Fri Jun 15 00:00:00 UTC 2012
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM
Sat Dec 01 00:00:00 UTC 2012
Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.
Journal of immunology (Baltimore, Md. : 1950)
Antal Z,Baker JC,Smith C,Jarchum I,Babad J,Mukherjee G,Yang Y,Sidney J,Sette A,Santamaria P,DiLorenzo TP
Fri Jun 01 00:00:00 UTC 2012
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
Benoit ME,Clarke EV,Morgado P,Fraser DA,Tenner AJ
Fri Jun 01 00:00:00 UTC 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 UTC 2012
Selective dependence of H2-M3-restricted CD8 responses on IL-15.
Journal of immunology (Baltimore, Md. : 1950)
Müller JR,Waldmann TA,Dubois S
Thu Mar 15 00:00:00 UTC 2012
Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells.
Journal of immunology (Baltimore, Md. : 1950)
Bosnjak L,Sahlström P,Paquin-Proulx D,Leeansyah E,Moll M,Sandberg JK
Fri Jun 15 00:00:00 UTC 2012
Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype.
Cellular microbiology
Portevin D,Via LE,Eum S,Young D
Thu Nov 01 00:00:00 UTC 2012
Characterization of T-cell responses against IκBα in cancer patients.
Oncoimmunology
Munir S,Frøsig TM,Hansen M,Svane IM,Andersen MH
Thu Nov 01 00:00:00 UTC 2012
Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.
Retrovirology
Meuwissen PJ,Stolp B,Iannucci V,Vermeire J,Naessens E,Saksela K,Geyer M,Vanham G,Arien KK,Fackler OT,Verhasselt B
Fri Apr 27 00:00:00 UTC 2012
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity.
Cell death & disease
Husak Z,Dworzak MN
Thu Nov 15 00:00:00 UTC 2012
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch.
PloS one
Wang C,Lee JH,Kim CH
Mon Jun 04 00:00:00 UTC 2012
Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.
PloS one
Dolganiuc A,Kodys K,Marshall C,Saha B,Zhang S,Bala S,Szabo G
Tue Apr 02 00:00:00 UTC 2013
The scaffolding protein Dlg1 is a negative regulator of cell-free virus infectivity but not of cell-to-cell HIV-1 transmission in T cells.
PloS one
Nzounza P,Chazal M,Guedj C,Schmitt A,Massé JM,Randriamampita C,Pique C,Ramirez BC
Mon Jun 11 00:00:00 UTC 2012
Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro.
The Journal of biological chemistry
Lv LH,Wan YL,Lin Y,Zhang W,Yang M,Li GL,Lin HM,Shang CZ,Chen YJ,Min J
Fri May 04 00:00:00 UTC 2012
Enhancement of myeloma development mediated though myeloma cell-Th2 cell interactions after microbial antigen presentation by myeloma cells and DCs.
Blood cancer journal
Tian F,Li J,Li Y,Luo S
Fri Jun 01 00:00:00 UTC 2012
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
The Journal of biological chemistry
Ekeruche-Makinde J,Clement M,Cole DK,Edwards ES,Ladell K,Miles JJ,Matthews KK,Fuller A,Lloyd KA,Madura F,Dolton GM,Pentier J,Lissina A,Gostick E,Baxter TK,Baker BM,Rizkallah PJ,Price DA,Wooldridge L,Sewell AK
Fri Oct 26 00:00:00 UTC 2012
Authentication of primordial characteristics of the CLBL-1 cell line prove the integrity of a canine B-cell lymphoma in a murine in vivo model.
PloS one
Rütgen BC,Willenbrock S,Reimann-Berg N,Walter I,Fuchs-Baumgartinger A,Wagner S,Kovacic B,Essler SE,Schwendenwein I,Nolte I,Saalmüller A,Murua Escobar H
Fri Jan 04 00:00:00 UTC 2013
Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells.
The Journal of biological chemistry
Macaire H,Riquet A,Moncollin V,Biémont-Trescol MC,Duc Dodon M,Hermine O,Debaud AL,Mahieux R,Mesnard JM,Pierre M,Gazzolo L,Bonnefoy N,Valentin H
Fri Jun 15 00:00:00 UTC 2012
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 UTC 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 UTC 2012
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
PloS one
Qi Y,Operario DJ,Georas SN,Mosmann TR
Thu Dec 13 00:00:00 UTC 2012
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.
PloS one
Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R
Wed Apr 24 00:00:00 UTC 2013
Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.
PloS one
Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW
Thu May 30 00:00:00 UTC 2013
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 UTC 2012
Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor.
The Journal of biological chemistry
Lai CB,Mager DL
Fri Mar 02 00:00:00 UTC 2012
Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor.
The Journal of biological chemistry
Lai CB,Mager DL
Fri Mar 02 00:00:00 UTC 2012
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.
PloS one
Kunisawa J,Hashimoto E,Ishikawa I,Kiyono H
Fri Jun 29 00:00:00 UTC 2012
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex.
The Journal of biological chemistry
Wun KS,Ross F,Patel O,Besra GS,Porcelli SA,Richardson SK,Keshipeddy S,Howell AR,Godfrey DI,Rossjohn J
Fri Nov 09 00:00:00 UTC 2012
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
The Journal of biological chemistry
Verma NK,Dempsey E,Long A,Davies A,Barry SP,Fallon PG,Volkov Y,Kelleher D
Fri Aug 03 00:00:00 UTC 2012
Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation.
Retrovirology
Bonnet A,Randrianarison-Huetz V,Nzounza P,Nedelec M,Chazal M,Waast L,Pene S,Bazarbachi A,Mahieux R,Bénit L,Pique C
Tue Sep 25 00:00:00 UTC 2012
Pegylated interferon α enhances recovery of memory T cells in e antigen positive chronic hepatitis B patients.
Virology journal
Liu YZ,Hou FQ,Ding P,Ren YY,Li SH,Wang GQ
Fri Nov 16 00:00:00 UTC 2012
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.
BMC cancer
Blix ES,Irish JM,Husebekk A,Delabie J,Forfang L,Tierens AM,Myklebust JH,Kolstad A
Tue Oct 16 00:00:00 UTC 2012
Macrophages help NK cells to attack tumor cells by stimulatory NKG2D ligand but protect themselves from NK killing by inhibitory ligand Qa-1.
PloS one
Zhou Z,Zhang C,Zhang J,Tian Z
Mon Dec 17 00:00:00 UTC 2012
T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating chemotherapy-resistant B-cell lymphoma cells overexpressing survivin induced by BMI-1.
Blood cancer journal
Bhattacharyya J,Mihara K,Kitanaka A,Yanagihara K,Kubo T,Takei Y,Kimura A,Takihara Y
Fri Jun 01 00:00:00 UTC 2012
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
Oncoimmunology
Mandapathil M,Szczepanski M,Harasymczuk M,Ren J,Cheng D,Jackson EK,Gorelik E,Johnson J,Lang S,Whiteside TL
Wed Aug 01 00:00:00 UTC 2012
Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model.
PloS one
Yang Z,Zhang Q,Xu K,Shan J,Shen J,Liu L,Xu Y,Xia F,Bie P,Zhang X,Cui Y,Bian XW,Qian C
Tue Mar 05 00:00:00 UTC 2013
Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype.
PloS one
Forget MA,Huon Y,Reuben A,Grange C,Liberman M,Martin J,Mes-Masson AM,Arbour N,Lapointe R
Thu Apr 11 00:00:00 UTC 2013
Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase.
PloS one
Munir S,Larsen SK,Iversen TZ,Donia M,Klausen TW,Svane IM,Straten PT,Andersen MH
Mon Sep 10 00:00:00 UTC 2012
Antibody-based protection against HIV infection by vectored immunoprophylaxis.
Nature
Balazs AB,Chen J,Hong CM,Rao DS,Yang L,Baltimore D
Wed Nov 30 00:00:00 UTC 2011
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 UTC 2011
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Immunity
Siegel AM,Heimall J,Freeman AF,Hsu AP,Brittain E,Brenchley JM,Douek DC,Fahle GH,Cohen JI,Holland SM,Milner JD
Wed Nov 23 00:00:00 UTC 2011
Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.
Cancer cell
Challa-Malladi M,Lieu YK,Califano O,Holmes AB,Bhagat G,Murty VV,Dominguez-Sola D,Pasqualucci L,Dalla-Favera R
Tue Dec 13 00:00:00 UTC 2011
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
Thu Feb 03 00:00:00 UTC 2011
CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.
Blood
Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G
Thu Apr 28 00:00:00 UTC 2011
DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction.
Blood
Ardolino M,Zingoni A,Cerboni C,Cecere F,Soriani A,Iannitto ML,Santoni A
Thu May 05 00:00:00 UTC 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 UTC 2011
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes.
Blood
Fox JM,Letellier E,Oliphant CJ,Signoret N
Thu Feb 10 00:00:00 UTC 2011
Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells.
Blood
Carlier J,Martin H,Mariamé B,Rauwel B,Mengelle C,Weclawiak H,Coaquette A,Vauchy C,Rohrlich P,Kamar N,Rostaing L,Herbein G,Davrinche C
Thu Dec 22 00:00:00 UTC 2011
Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.
Blood
Costa G,Loizon S,Guenot M,Mocan I,Halary F,de Saint-Basile G,Pitard V,Déchanet-Merville J,Moreau JF,Troye-Blomberg M,Mercereau-Puijalon O,Behr C
Thu Dec 22 00:00:00 UTC 2011
T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets.
Blood
Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG
Thu Sep 22 00:00:00 UTC 2011
Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity.
Blood
Kim TD,Lee SU,Yun S,Sun HN,Lee SH,Kim JW,Kim HM,Park SK,Lee CW,Yoon SR,Greenberg PD,Choi I
Thu Nov 17 00:00:00 UTC 2011
Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.
Blood
Chung JS,Shiue LH,Duvic M,Pandya A,Cruz PD,Ariizumi K
Thu Mar 24 00:00:00 UTC 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
Mon Mar 14 00:00:00 UTC 2011
Mobilization of natural killer cells inhibits development of collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Leavenworth JW,Wang X,Wenander CS,Spee P,Cantor H
Tue Aug 30 00:00:00 UTC 2011
Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.
Proceedings of the National Academy of Sciences of the United States of America
Adams WC,Gujer C,McInerney G,Gall JG,Petrovas C,Karlsson Hedestam GB,Koup RA,Loré K
Tue May 03 00:00:00 UTC 2011
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
PLoS biology
Tauzin S,Chaigne-Delalande B,Selva E,Khadra N,Daburon S,Contin-Bordes C,Blanco P,Le Seyec J,Ducret T,Counillon L,Moreau JF,Hofman P,Vacher P,Legembre P
Wed Jun 01 00:00:00 UTC 2011
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
PLoS pathogens
Pido-Lopez J,Kwok WW,Mitchell TJ,Heyderman RS,Williams NA
Thu Dec 01 00:00:00 UTC 2011
Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.
Cancer immunology, immunotherapy : CII
Andersen RS,Sørensen RB,Ritter C,Svane IM,Becker JC,thor Straten P,Andersen MH
Tue Feb 01 00:00:00 UTC 2011
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.
Journal of virology
Ferrari G,Pollara J,Kozink D,Harms T,Drinker M,Freel S,Moody MA,Alam SM,Tomaras GD,Ochsenbauer C,Kappes JC,Shaw GM,Hoxie JA,Robinson JE,Haynes BF
Fri Jul 01 00:00:00 UTC 2011
Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells.
Journal of immunology (Baltimore, Md. : 1950)
Neunkirchner A,Leb-Reichl VM,Schmetterer KG,Mutschlechner S,Kueng HJ,Haiderer D,Schuch K,Wallner M,Jahn-Schmid B,Bohle B,Pickl WF
Sat Oct 15 00:00:00 UTC 2011
Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1.
Journal of immunology (Baltimore, Md. : 1950)
Kudela P,Sun Z,Fourcade J,Janjic B,Kirkwood JM,Maillere B,Zarour HM
Sat Jan 01 00:00:00 UTC 2011
The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Baeke F,Korf H,Overbergh L,Verstuyf A,Thorrez L,Van Lommel L,Waer M,Schuit F,Gysemans C,Mathieu C
Sat Jan 01 00:00:00 UTC 2011
Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague.
Journal of immunology (Baltimore, Md. : 1950)
Lin JS,Szaba FM,Kummer LW,Chromy BA,Smiley ST
Fri Jul 15 00:00:00 UTC 2011
Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect.
Journal of immunology (Baltimore, Md. : 1950)
Lee FE,Halliley JL,Walsh EE,Moscatiello AP,Kmush BL,Falsey AR,Randall TD,Kaminiski DA,Miller RK,Sanz I
Sun May 01 00:00:00 UTC 2011
A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Zhou R,Horai R,Mattapallil MJ,Caspi RR
Sat Oct 15 00:00:00 UTC 2011
A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Zhou R,Horai R,Mattapallil MJ,Caspi RR
Sat Oct 15 00:00:00 UTC 2011
Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K
Tue Feb 01 00:00:00 UTC 2011
IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.
PloS one
Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B
Mon Aug 27 00:00:00 UTC 2012
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
The Journal of biological chemistry
San Luis B,Sondgeroth B,Nassar N,Carpino N
Fri May 06 00:00:00 UTC 2011
Growth of human colorectal cancer SW1116 cells is inhibited by cytokine-induced killer cells.
Clinical & developmental immunology
Wang Y,Dai H,Li H,Lv H,Wang T,Fu X,Han W
Tue Aug 02 00:00:00 UTC 2011
Human ovarian tumor cells escape γδ T cell recognition partly by down regulating surface expression of MICA and limiting cell cycle related molecules.
PloS one
Lu J,Aggarwal R,Kanji S,Das M,Joseph M,Pompili V,Das H
Fri Apr 13 00:00:00 UTC 2012
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
PloS one
Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X
Mon Aug 27 00:00:00 UTC 2012
HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells.
Retrovirology
Gibellini D,Alviano F,Miserocchi A,Tazzari PL,Ricci F,Clò A,Morini S,Borderi M,Viale P,Pasquinelli G,Pagliaro P,Bagnara GP,Re MC
Wed May 25 00:00:00 UTC 2011
A practical approach to T-cell receptor cloning and expression.
PloS one
Wälchli S,Løset GÅ,Kumari S,Johansen JN,Yang W,Sandlie I,Olweus J
Mon Apr 02 00:00:00 UTC 2012
Cell docking, movement and cell-cell interactions of heterogeneous cell suspensions in a cell manipulation microdevice.
Sensors (Basel, Switzerland)
Lai FL,Wang YH,Chung YW,Hwang SM,Huang LS
Tue Jun 05 00:00:00 UTC 2012
Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.
Journal of neuroinflammation
Dao MA,Tate CC,Aizman I,McGrogan M,Case CC
Fri Oct 07 00:00:00 UTC 2011
Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.
PloS one
Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G
Mon Aug 27 00:00:00 UTC 2012
Host-based Th2 cell therapy for prolongation of cardiac allograft viability.
PloS one
Amarnath S,Chen H,Foley JE,Costanzo CM,Sennesh JD,Solomon MA,Fowler DH
Fri Apr 29 00:00:00 UTC 2011
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg.
PloS one
Yamamoto M,Kondo E,Takeuchi M,Harashima A,Otani T,Tsuji-Takayama K,Yamasaki F,Kumon H,Kibata M,Nakamura S
Thu Feb 03 00:00:00 UTC 2011
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg.
PloS one
Yamamoto M,Kondo E,Takeuchi M,Harashima A,Otani T,Tsuji-Takayama K,Yamasaki F,Kumon H,Kibata M,Nakamura S
Thu Feb 03 00:00:00 UTC 2011
Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials.
Journal of translational medicine
Fučíková J,Rožková D,Ulčová H,Budinský V,Sochorová K,Pokorná K,Bartůňková J,Špíšek R
Fri Dec 30 00:00:00 UTC 2011
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 UTC 2011
Ex vivo expansion of tumor-reactive T cells by means of bryostatin 1/ionomycin and the common gamma chain cytokines formulation.
Journal of visualized experiments : JoVE
Kmieciak M,Toor A,Graham L,Bear HD,Manjili MH
Fri Jan 14 00:00:00 UTC 2011
Enhanced transduction and replication of RGD-fiber modified adenovirus in primary T cells.
PloS one
Sengupta S,Ulasov IV,Thaci B,Ahmed AU,Lesniak MS
Mon Mar 28 00:00:00 UTC 2011
Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression.
PloS one
Gutierrez A,Arendt BK,Tschumper RC,Kay NE,Zent CS,Jelinek DF
Mon Feb 13 00:00:00 UTC 2012
CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
BMC immunology
Wang XB,Fan ZZ,Anton D,Vollenhoven AV,Ni ZH,Chen XF,Lefvert AK
Fri Mar 18 00:00:00 UTC 2011
Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.
BMC immunology
Awong G,Herer E,La Motte-Mohs RN,Zúñiga-Pflücker JC
Wed Mar 23 00:00:00 UTC 2011
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
PloS one
Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T
Mon Mar 26 00:00:00 UTC 2012
Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies.
Journal of translational medicine
Tischer S,Basila M,Maecker-Kolhoff B,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B
Wed Oct 12 00:00:00 UTC 2011
Evaluation of Epstein-Barr virus latent membrane protein 2 specific T-cell receptors driven by T-cell specific promoters using lentiviral vector.
Clinical & developmental immunology
Yang D,Shao Q,Sun H,Mu X,Gao Y,Jiang R,Hou J,Yao K,Chen Y,Sun B
Wed Jan 18 00:00:00 UTC 2012
Plasmodium falciparum-infected erythrocytes and IL-12/IL-18 induce diverse transcriptomes in human NK cells: IFN-α/β pathway versus TREM signaling.
PloS one
Grangeiro de Carvalho E,Bonin M,Kremsner PG,Kun JF
Fri Feb 03 00:00:00 UTC 2012
MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27.
Blood
Frenquelli M,Muzio M,Scielzo C,Fazi C,Scarfò L,Rossi C,Ferrari G,Ghia P,Caligaris-Cappio F
Thu May 13 00:00:00 UTC 2010
LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis.
Blood
Gutierrez A,Tschumper RC,Wu X,Shanafelt TD,Eckel-Passow J,Huddleston PM,Slager SL,Kay NE,Jelinek DF
Thu Oct 21 00:00:00 UTC 2010
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.
Blood
Racanelli V,Leone P,Frassanito MA,Brunetti C,Perosa F,Ferrone S,Dammacco F
Thu Feb 11 00:00:00 UTC 2010
Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates.
Blood
Lugli E,Goldman CK,Perera LP,Smedley J,Pung R,Yovandich JL,Creekmore SP,Waldmann TA,Roederer M
Thu Oct 28 00:00:00 UTC 2010
Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4.
Blood
Scott-Algara D,Balabanian K,Chakrabarti LA,Mouthon L,Dromer F,Didier C,Arenzana-Seisdedos F,Lortholary O
Thu May 06 00:00:00 UTC 2010
Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection.
Blood
Muntasell A,Magri G,Pende D,Angulo A,López-Botet M
Thu Jun 24 00:00:00 UTC 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 UTC 2010
Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells.
Cellular & molecular immunology
Suzuki T,Oo Chang M,Kitajima M,Takaku H
Mon Nov 01 00:00:00 UTC 2010
OX40 is required for regulatory T cell-mediated control of colitis.
The Journal of experimental medicine
Griseri T,Asquith M,Thompson C,Powrie F
Mon Apr 12 00:00:00 UTC 2010
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
The Journal of experimental medicine
Fourcade J,Sun Z,Benallaoua M,Guillaume P,Luescher IF,Sander C,Kirkwood JM,Kuchroo V,Zarour HM
Mon Sep 27 00:00:00 UTC 2010
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.
The Journal of experimental medicine
Gottschalk RA,Corse E,Allison JP
Mon Aug 02 00:00:00 UTC 2010
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates.
The Journal of experimental medicine
Sundling C,Forsell MN,O'Dell S,Feng Y,Chakrabarti B,Rao SS,Loré K,Mascola JR,Wyatt RT,Douagi I,Karlsson Hedestam GB
Mon Aug 30 00:00:00 UTC 2010
Immunotherapy for human renal cell carcinoma by adoptive transfer of autologous transforming growth factor beta-insensitive CD8+ T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Wang L,Wen W,Yuan J,Helfand B,Li Y,Shi C,Tian F,Zheng J,Wang F,Chen L,Liang L,Zhou L,Lee C,Chen Z,Guo Y,Wang H,Zhang Q,Qin W
Fri Jan 01 00:00:00 UTC 2010
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Autophagy
Amarnath S,Flomerfelt FA,Costanzo CM,Foley JE,Mariotti J,Konecki DM,Gangopadhyay A,Eckhaus M,Wong S,Levine BL,June CH,Fowler DH
200-02 was used in Cell Culture to study the nature and mechanism by which rapamycin maintains the ability of Tregs to differentiate.
Sat May 01 00:00:00 UTC 2010
Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2.
Proceedings of the National Academy of Sciences of the United States of America
Leavenworth JW,Schellack C,Kim HJ,Lu L,Spee P,Cantor H
Tue Feb 09 00:00:00 UTC 2010
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS biology
Amarnath S,Costanzo CM,Mariotti J,Ullman JL,Telford WG,Kapoor V,Riley JL,Levine BL,June CH,Fong T,Warner NL,Fowler DH
Tue Feb 02 00:00:00 UTC 2010
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.
Journal of clinical immunology
Heidemann SC,Chavez V,Landers CJ,Kucharzik T,Prehn JL,Targan SR
Thu Jul 01 00:00:00 UTC 2010
Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1.
PLoS pathogens
Melki MT,Saïdi H,Dufour A,Olivo-Marin JC,Gougeon ML
Thu Apr 15 00:00:00 UTC 2010
In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors.
Cancer immunology, immunotherapy : CII
Berthon C,Driss V,Liu J,Kuranda K,Leleu X,Jouy N,Hetuin D,Quesnel B
Wed Dec 01 00:00:00 UTC 2010
PRDM1/Blimp-1 controls effector cytokine production in human NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Smith MA,Maurin M,Cho HI,Becknell B,Freud AG,Yu J,Wei S,Djeu J,Celis E,Caligiuri MA,Wright KL
Mon Nov 15 00:00:00 UTC 2010
Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Ni L,Gayet I,Zurawski S,Duluc D,Flamar AL,Li XH,O'Bar A,Clayton S,Palucka AK,Zurawski G,Banchereau J,Oh S
Wed Sep 15 00:00:00 UTC 2010
Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer.
Journal of immunology (Baltimore, Md. : 1950)
Tabi Z,Spary LK,Coleman S,Clayton A,Mason MD,Staffurth J
Thu Jul 15 00:00:00 UTC 2010
CD8 controls T cell cross-reactivity.
Journal of immunology (Baltimore, Md. : 1950)
Wooldridge L,Laugel B,Ekeruche J,Clement M,van den Berg HA,Price DA,Sewell AK
Fri Oct 15 00:00:00 UTC 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 UTC 2010
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Yeh N,Glosson NL,Wang N,Guindon L,McKinley C,Hamada H,Li Q,Dutton RW,Shrikant P,Zhou B,Brutkiewicz RR,Blum JS,Kaplan MH
Sun Aug 15 00:00:00 UTC 2010
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Tan AH,Lam KP
Mon Feb 15 00:00:00 UTC 2010
Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.
Journal of immunology (Baltimore, Md. : 1950)
Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J
Wed Dec 01 00:00:00 UTC 2010
Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950)
Fourcade J,Sun Z,Kudela P,Janjic B,Kirkwood JM,El-Hafnawy T,Zarour HM
Tue Jun 15 00:00:00 UTC 2010
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions.
Journal of immunology (Baltimore, Md. : 1950)
Zou T,Caton AJ,Koretzky GA,Kambayashi T
Wed Sep 01 00:00:00 UTC 2010
Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.
Journal of immunology (Baltimore, Md. : 1950)
Jarchum I,DiLorenzo TP
Fri Jan 15 00:00:00 UTC 2010
A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression.
Journal of immunology (Baltimore, Md. : 1950)
Liu J,Shaji D,Cho S,Du W,Gervay-Hague J,Brutkiewicz RR
Sat May 01 00:00:00 UTC 2010
CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Nesbeth YC,Martinez DG,Toraya S,Scarlett UK,Cubillos-Ruiz JR,Rutkowski MR,Conejo-Garcia JR
Sat May 15 00:00:00 UTC 2010
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Journal of immunology (Baltimore, Md. : 1950)
Wooldridge L,Clement M,Lissina A,Edwards ES,Ladell K,Ekeruche J,Hewitt RE,Laugel B,Gostick E,Cole DK,Debets R,Berrevoets C,Miles JJ,Burrows SR,Price DA,Sewell AK
Thu Apr 01 00:00:00 UTC 2010
An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Martin JF,Perry JS,Jakhete NR,Wang X,Bielekova B
Thu Jul 15 00:00:00 UTC 2010
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Suchard SJ,Stetsko DK,Davis PM,Skala S,Potin D,Launay M,Dhar TG,Barrish JC,Susulic V,Shuster DJ,McIntyre KW,McKinnon M,Salter-Cid L
Thu Apr 01 00:00:00 UTC 2010
Adenovirus F protein as a delivery vehicle for botulinum B.
BMC immunology
Clapp B,Golden S,Maddaloni M,Staats HF,Pascual DW
Wed Jul 07 00:00:00 UTC 2010
Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation.
Journal of translational medicine
Li Y,Kurlander RJ
Tue Oct 26 00:00:00 UTC 2010
Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.
PloS one
Morteau O,Blundell S,Chakera A,Bennett S,Christou CM,Mason PD,Cornall RJ,O'Callaghan CA
Tue Oct 12 00:00:00 UTC 2010
Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells.
PloS one
Wu X,Tschumper RC,Gutierrez A,Mihalcik SA,Nowakowski GS,Jelinek DF
Thu Dec 16 00:00:00 UTC 2010
miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy.
Journal of translational medicine
Sasaki K,Kohanbash G,Hoji A,Ueda R,McDonald HA,Reinhart TA,Martinson J,Lotze MT,Marincola FM,Wang E,Fujita M,Okada H
Thu Feb 18 00:00:00 UTC 2010
miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy.
Journal of translational medicine
Sasaki K,Kohanbash G,Hoji A,Ueda R,McDonald HA,Reinhart TA,Martinson J,Lotze MT,Marincola FM,Wang E,Fujita M,Okada H
Thu Feb 18 00:00:00 UTC 2010
CXCL10 can inhibit endothelial cell proliferation independently of CXCR3.
PloS one
Campanella GS,Colvin RA,Luster AD
Mon Sep 13 00:00:00 UTC 2010
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes.
PloS one
Brown ME,Rondon E,Rajesh D,Mack A,Lewis R,Feng X,Zitur LJ,Learish RD,Nuwaysir EF
Tue Jun 29 00:00:00 UTC 2010
Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.
Journal of immune based therapies and vaccines
Drozdowski B,Zhou Y,Kline B,Spidel J,Chan YY,Albone E,Turchin H,Chao Q,Henry M,Balogach J,Routhier E,Bavari S,Nicolaides NC,Sass PM,Grasso L
Tue Dec 21 00:00:00 UTC 2010
Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms.
The Journal of biological chemistry
Thielen BK,McNevin JP,McElrath MJ,Hunt BV,Klein KC,Lingappa JR
Fri Sep 03 00:00:00 UTC 2010
CC chemokine receptor 5 (CCR5) desensitization: cycling receptors accumulate in the trans-Golgi network.
The Journal of biological chemistry
Escola JM,Kuenzi G,Gaertner H,Foti M,Hartley O
Fri Dec 31 00:00:00 UTC 2010
Retroviral transduction of T-cell receptors in mouse T-cells.
Journal of visualized experiments : JoVE
Zhong S,Malecek K,Perez-Garcia A,Krogsgaard M
Fri Oct 22 00:00:00 UTC 2010
Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.
Blood
Azakami K,Sato T,Araya N,Utsunomiya A,Kubota R,Suzuki K,Hasegawa D,Izumi T,Fujita H,Aratani S,Fujii R,Yagishita N,Kamijuku H,Kanekura T,Seino K,Nishioka K,Nakajima T,Yamano Y
Thu Oct 08 00:00:00 UTC 2009
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.
Blood
Rezvani K,Yong AS,Tawab A,Jafarpour B,Eniafe R,Mielke S,Savani BN,Keyvanfar K,Li Y,Kurlander R,Barrett AJ
Thu Mar 05 00:00:00 UTC 2009
Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.
Blood
Kawaguchi A,Orba Y,Kimura T,Iha H,Ogata M,Tsuji T,Ainai A,Sata T,Okamoto T,Hall WW,Sawa H,Hasegawa H
Thu Oct 01 00:00:00 UTC 2009
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.
Blood
Tran DQ,Andersson J,Hardwick D,Bebris L,Illei GG,Shevach EM
Thu May 21 00:00:00 UTC 2009
Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans.
Blood
Fenoglio D,Poggi A,Catellani S,Battaglia F,Ferrera A,Setti M,Murdaca G,Zocchi MR
Thu Jun 25 00:00:00 UTC 2009
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.
Blood
Yong AS,Keyvanfar K,Hensel N,Eniafe R,Savani BN,Berg M,Lundqvist A,Adams S,Sloand EM,Goldman JM,Childs R,Barrett AJ
Thu Jan 22 00:00:00 UTC 2009
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.
Blood
Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B
Thu Mar 26 00:00:00 UTC 2009
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
Blood
Calado RT,Yewdell WT,Wilkerson KL,Regal JA,Kajigaya S,Stratakis CA,Young NS
Thu Sep 10 00:00:00 UTC 2009
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.
Blood
Ahlen MT,Husebekk A,Killie MK,Skogen B,Stuge TB
Thu Apr 16 00:00:00 UTC 2009
Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells.
Blood
Cerboni C,Ardolino M,Santoni A,Zingoni A
Thu Mar 26 00:00:00 UTC 2009
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.
The Journal of clinical investigation
Snow AL,Marsh RA,Krummey SM,Roehrs P,Young LR,Zhang K,van Hoff J,Dhar D,Nichols KE,Filipovich AH,Su HC,Bleesing JJ,Lenardo MJ
Thu Oct 01 00:00:00 UTC 2009
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.
The Journal of clinical investigation
Côte M,Ménager MM,Burgess A,Mahlaoui N,Picard C,Schaffner C,Al-Manjomi F,Al-Harbi M,Alangari A,Le Deist F,Gennery AR,Prince N,Cariou A,Nitschke P,Blank U,El-Ghazali G,Ménasché G,Latour S,Fischer A,de Saint Basile G
Tue Dec 01 00:00:00 UTC 2009
Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.
The Journal of clinical investigation
Song L,Asgharzadeh S,Salo J,Engell K,Wu HW,Sposto R,Ara T,Silverman AM,DeClerck YA,Seeger RC,Metelitsa LS
Mon Jun 01 00:00:00 UTC 2009
Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ueda R,Fujita M,Zhu X,Sasaki K,Kastenhuber ER,Kohanbash G,McDonald HA,Harper J,Lonning S,Okada H
Sun Nov 01 00:00:00 UTC 2009
A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3.
Clinical cancer research : an official journal of the American Association for Cancer Research
Trimble CL,Peng S,Kos F,Gravitt P,Viscidi R,Sugar E,Pardoll D,Wu TC
Thu Jan 01 00:00:00 UTC 2009
Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.
Cancer research
Kawabe M,Mandic M,Taylor JL,Vasquez CA,Wesa AK,Neckers LM,Storkus WJ
Tue Sep 01 00:00:00 UTC 2009
A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.
Molecular therapy : the journal of the American Society of Gene Therapy
Scobie L,Hector RD,Grant L,Bell M,Nielsen AA,Meikle S,Philbey A,Thrasher AJ,Cameron ER,Blyth K,Neil JC
Mon Jun 01 00:00:00 UTC 2009
Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles.
Leukemia
Plander M,Seegers S,Ugocsai P,Diermeier-Daucher S,Iványi J,Schmitz G,Hofstädter F,Schwarz S,Orsó E,Knüchel R,Brockhoff G
Sun Nov 01 00:00:00 UTC 2009
Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Parish IA,Waithman J,Davey GM,Belz GT,Mintern JD,Kurts C,Sutherland RM,Carbone FR,Heath WR
Tue Mar 10 00:00:00 UTC 2009
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Tran DQ,Andersson J,Wang R,Ramsey H,Unutmaz D,Shevach EM
Tue Aug 11 00:00:00 UTC 2009
IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.
Cell death and differentiation
Czystowska M,Han J,Szczepanski MJ,Szajnik M,Quadrini K,Brandwein H,Hadden JW,Signorelli K,Whiteside TL
Fri May 01 00:00:00 UTC 2009
High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.
PLoS pathogens
Enose-Akahata Y,Matsuura E,Oh U,Jacobson S
Tue Dec 01 00:00:00 UTC 2009
Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates.
Immunology and cell biology
Brady JL,Mannering SI,Kireta S,Coates PT,Proietto AI,Cowan PJ,D'Apice AJ,Lew AM
Wed Jul 01 00:00:00 UTC 2009
Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers.
Journal of immunology (Baltimore, Md. : 1950)
Rayment R,Kooij TW,Zhang W,Siebold C,Murphy MF,Allen D,Willcox N,Roberts DJ
Wed Jul 01 00:00:00 UTC 2009
Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1.
Journal of immunology (Baltimore, Md. : 1950)
Ouaked N,Mantel PY,Bassin C,Burgler S,Siegmund K,Akdis CA,Schmidt-Weber CB
Thu Jan 15 00:00:00 UTC 2009
Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide.
Journal of immunology (Baltimore, Md. : 1950)
Pozo D,Anderson P,Gonzalez-Rey E
Thu Oct 01 00:00:00 UTC 2009
The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics.
Journal of immunology (Baltimore, Md. : 1950)
Pickard C,Louafi F,McGuire C,Lowings K,Kumar P,Cooper H,Dearman RJ,Cumberbatch M,Kimber I,Healy E,Friedmann PS
Tue Dec 01 00:00:00 UTC 2009
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
Journal of immunology (Baltimore, Md. : 1950)
Tran DQ,Glass DD,Uzel G,Darnell DA,Spalding C,Holland SM,Shevach EM
Sun Mar 01 00:00:00 UTC 2009
Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro.
Journal of immunology (Baltimore, Md. : 1950)
Lipscomb MW,Chen L,Taylor JL,Goldbach C,Watkins SC,Kalinski P,Butterfield LH,Wesa AK,Storkus WJ
Tue Dec 01 00:00:00 UTC 2009
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.
Journal of immunology (Baltimore, Md. : 1950)
Chang BY,Zhao F,He X,Ren H,Braselmann S,Taylor V,Wicks J,Payan DG,Grossbard EB,Pine PR,Bullard DC
Sat Aug 01 00:00:00 UTC 2009
Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment.
Journal of immunology (Baltimore, Md. : 1950)
Gonzalez VD,Falconer K,Björkström NK,Blom KG,Weiland O,Ljunggren HG,Alaeus A,Sandberg JK
Sun Nov 15 00:00:00 UTC 2009
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Tomala J,Chmelova H,Mrkvan T,Rihova B,Kovar M
Thu Oct 15 00:00:00 UTC 2009
Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway.
Journal of immunology (Baltimore, Md. : 1950)
Noursadeghi M,Tsang J,Miller RF,Straschewski S,Kellam P,Chain BM,Katz DR
Thu Jan 01 00:00:00 UTC 2009
PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950)
Fourcade J,Kudela P,Sun Z,Shen H,Land SR,Lenzner D,Guillaume P,Luescher IF,Sander C,Ferrone S,Kirkwood JM,Zarour HM
Fri May 01 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance.
Journal of immunology (Baltimore, Md. : 1950)
Godin-Ethier J,Pelletier S,Hanafi LA,Gannon PO,Forget MA,Routy JP,Boulassel MR,Krzemien U,Tanguay S,Lattouf JB,Arbour N,Lapointe R
Tue Dec 15 00:00:00 UTC 2009
JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1.
Journal of immunology (Baltimore, Md. : 1950)
Kumar D,Hosse J,von Toerne C,Noessner E,Nelson PJ
Thu Jan 15 00:00:00 UTC 2009
Helios deficiency has minimal impact on T cell development and function.
Journal of immunology (Baltimore, Md. : 1950)
Cai Q,Dierich A,Oulad-Abdelghani M,Chan S,Kastner P
Sat Aug 15 00:00:00 UTC 2009
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
Journal of immunology (Baltimore, Md. : 1950)
Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L
Fri May 15 00:00:00 UTC 2009
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 UTC 2009
Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes.
Human gene therapy
Rabinovich PM,Komarovskaya ME,Wrzesinski SH,Alderman JL,Budak-Alpdogan T,Karpikov A,Guo H,Flavell RA,Cheung NK,Weissman SM,Bahceci E
Thu Jan 01 00:00:00 UTC 2009
Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis.
PLoS pathogens
Chung JW,Piao ZH,Yoon SR,Kim MS,Jeong M,Lee SH,Min JK,Kim JW,Cho YH,Kim JC,Ahn JK,Kim KE,Choi I
200-02 was used in Cell Culture to suggest that the phagocytosis of PA by NK cells is a critical event that affects the relapse of diseases in immunocompromised patients, such as those with cancer, and provides important insights into the interactions between PA and NK cells.
Sat Aug 01 00:00:00 UTC 2009
The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.
PloS one
Sørensen RB,Berge-Hansen L,Junker N,Hansen CA,Hadrup SR,Schumacher TN,Svane IM,Becker JC,thor Straten P,Andersen MH
Mon Sep 07 00:00:00 UTC 2009
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
Journal of translational medicine
Kmieciak M,Gowda M,Graham L,Godder K,Bear HD,Marincola FM,Manjili MH
Thu Oct 22 00:00:00 UTC 2009
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.
Blood
Loos T,Mortier A,Gouwy M,Ronsse I,Put W,Lenaerts JP,Van Damme J,Proost P
Wed Oct 01 00:00:00 UTC 2008
Induction of CD4+ T-cell anergy and apoptosis by activated human B cells.
Blood
Tretter T,Venigalla RK,Eckstein V,Saffrich R,Sertel S,Ho AD,Lorenz HM
Mon Dec 01 00:00:00 UTC 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 UTC 2008
alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
Proceedings of the National Academy of Sciences of the United States of America
Lewis EC,Mizrahi M,Toledano M,Defelice N,Wright JL,Churg A,Shapiro L,Dinarello CA
Tue Oct 21 00:00:00 UTC 2008
Galectin-1 promotes immunoglobulin production during plasma cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CM,Chiu YK,Hsu TL,Lin IY,Hsieh SL,Lin KI
Wed Oct 01 00:00:00 UTC 2008
Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists.
Journal of immunology (Baltimore, Md. : 1950)
Wesa AK,Herrem CJ,Mandic M,Taylor JL,Vasquez C,Kawabe M,Tatsumi T,Leibowitz MS,Finke JH,Bukowski RM,Bruckheimer E,Kinch MS,Storkus WJ
Mon Dec 01 00:00:00 UTC 2008
Interferon-alpha controls IL-17 expression in vitro and in vivo.
Immunobiology
Moschen AR,Geiger S,Krehan I,Kaser A,Tilg H
Thu Feb 05 00:00:00 UTC 2009
HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk.
PloS one
Saïdi H,Melki MT,Gougeon ML
Thu Feb 12 00:00:00 UTC 2009
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
PloS one
Bauler TJ,Hendriks WJ,King PD
Thu Feb 19 00:00:00 UTC 2009
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature
Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ
Thu Aug 31 00:00:00 UTC 2006
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 UTC 2006
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.
Blood
Howard OM,Dong HF,Su SB,Caspi RR,Chen X,Plotz P,Oppenheim JJ
Wed Jun 01 00:00:00 UTC 2005
Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors.
Journal of immunology (Baltimore, Md. : 1950)
Poggi A,Prevosto C,Massaro AM,Negrini S,Urbani S,Pierri I,Saccardi R,Gobbi M,Zocchi MR
Tue Nov 15 00:00:00 UTC 2005
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950)
van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P
Tue Feb 15 00:00:00 UTC 2005
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 UTC 2004
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.
The Journal of clinical investigation
Courtois G,Smahi A,Reichenbach J,Döffinger R,Cancrini C,Bonnet M,Puel A,Chable-Bessia C,Yamaoka S,Feinberg J,Dupuis-Girod S,Bodemer C,Livadiotti S,Novelli F,Rossi P,Fischer A,Israël A,Munnich A,Le Deist F,Casanova JL
Wed Oct 01 00:00:00 UTC 2003
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 UTC 2003
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.
Journal of immunology (Baltimore, Md. : 1950)
Nibbs RJ,Salcedo TW,Campbell JD,Yao XT,Li Y,Nardelli B,Olsen HS,Morris TS,Proudfoot AE,Patel VP,Graham GJ
Tue Feb 01 00:00:00 UTC 2000
Disturbed CD4+ T cell homeostasis and in vitro HIV-1 susceptibility in transgenic mice expressing T cell line-tropic HIV-1 receptors.
The Journal of experimental medicine
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Mon May 04 00:00:00 UTC 1998
