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Invitrogen
Human R-Spondin 1 (aa 1-146) His-tag Recombinant Protein
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Product Details
RP-88158
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Met1-Ala146
Tag
His-tag
Molecular weight
23 kDa
Class
Recombinant
Type
Protein
Purity
>98% as determined by SDS-PAGE.
Activity
1. Measured by its ability to bind recombinant mouse CD36 in a functional ELISA. 2. Measured by its ability to induce activation of beta-catenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. The ED50 for this effect is typically 0.1-0.5 µg/mL in the presence of 5 ng/mL recombinant mouse Wnt3a.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (4000 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40906; hRspo1; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1
Gene Aliases: CRISTIN3; RSPO; RSPO1
UniProt ID: (Human) Q2MKA7
Entrez Gene ID: (Human) 284654
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