Product References
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.
Cancer cell
Wienke J,Visser LL,Kholosy WM,Keller KM,Barisa M,Poon E,Munnings-Tomes S,Himsworth C,Calton E,Rodriguez A,Bernardi R,van den Ham F,van Hooff SR,Matser YAH,Tas ML,Langenberg KPS,Lijnzaad P,Borst AL,Zappa E,Bergsma FJ,Strijker JGM,Verhoeven BM,Mei S,Kramdi A,Restuadi R,Sanchez-Bernabeu A,Cornel AM,Holstege FCP,Gray JC,Tytgat GAM,Scheijde-Vermeulen MA,Wijnen MHWA,Dierselhuis MP,Straathof K,Behjati S,Wu W,Heck AJR,Koster J,Nierkens S,Janoueix-Lerosey I,de Krijger RR,Baryawno N,Chesler L,Anderson J,Caron HN,Margaritis T,van Noesel MM,Molenaar JJ
100-21 was used in In vitro experiments to dissect the immunoregulatory interactions in neuroblastoma by single-cell RNA-sequencing of 24 tumors (10 pre- and 14 post-chemotherapy, including 5 pairs) to identify strategies for optimizing immunotherapy efficacy.
Mon Feb 12 00:00:00 UTC 2024
Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.
iScience
Liu F,Lin Q,Shen S,Li Z,Xie X,Cheng Q,Wang L,Long Y,Wang J,Liu L
100-21 was used in In vitro experiments to design an extracellular matrix (ECM)-adhesion mimic hydrogel for intrauterine administration, which was more effective than direct injection in treating intrauterine adhesions.
Fri Jun 21 00:00:00 UTC 2024
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.
The European respiratory journal
Shu T,Zhang J,Zhou Y,Chen Z,Li J,Tang Q,Lei W,Xing Y,Wang J,Wang C
100-21 was used in In vitro experiments to show that in PH development without external inflammatory stimulus, peripheral blood exhibits a low EOS level, in which EOS play a protective role through suppressing perivascular inflammation and maintaining PASMC homeostasis via 14/17-HDHA.
Wed Mar 01 00:00:00 UTC 2023
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell metabolism
Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A
100-21 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.
Tue May 02 00:00:00 UTC 2023
Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration.
Cellular & molecular biology letters
Li X,Shi W,Wei G,Lv J,Wang D,Xing B,Zhou J,Zhao J,Sun H
100-21 was used in Tissue/organ culture to find that Galectin-1 (GAL-1), which can be used as a marker in some tumors, is highly expressed in ASCs.
Mon May 15 00:00:00 UTC 2023
Transcriptional regulation of Glis2 in hepatic fibrosis.
Experimental & molecular medicine
Gong HY,Zhou PC,Zhang HY,Chen LM,Zhou YM,Liu ZG
100-21 was used in Cell Culture to investigate the functional and molecular mechanisms involved in the Glis2-mediated activation of hepatic stellate cells (HSCs).
Sat Jul 01 00:00:00 UTC 2023
Early human lung immune cell development and its role in epithelial cell fate.
Science immunology
Barnes JL,Yoshida M,He P,Worlock KB,Lindeboom RGH,Suo C,Pett JP,Wilbrey-Clark A,Dann E,Mamanova L,Richardson L,Polanski K,Pennycuick A,Allen-Hyttinen J,Herczeg IT,Arzili R,Hynds RE,Teixeira VH,Haniffa M,Lim K,Sun D,Rawlins EL,Oliver AJ,Lyons PA,Marioni JC,Ruhrberg C,Tuong ZK,Clatworthy MR,Reading JL,Janes SM,Teichmann SA,Meyer KB,Nikolić MZ
100-21 was used in Cell activation to profile human embryonic and foetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry to find that IL-1β drives epithelial progenitor exit from self-renewal and differentiation to basal cells in vitro.
Fri Dec 15 00:00:00 UTC 2023
USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.
Cellular oncology (Dordrecht, Netherlands)
Zhao B,Huo W,Yu X,Shi X,Lv L,Yang Y,Kang J,Li S,Wu H
100-21 was used in In vitro experiments to show that USP13 may play an essential role in breast cancer metastasis by regulating Twist1 and, as such, provide a potential target for the clinical treatment of breast cancer.
Thu Jun 01 00:00:00 UTC 2023
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Immunity
Kiss MG,Mindur JE,Yates AG,Lee D,Fullard JF,Anzai A,Poller WC,Christie KA,Iwamoto Y,Roudko V,Downey J,Chan CT,Huynh P,Janssen H,Ntranos A,Hoffmann JD,Jacob W,Goswami S,Singh S,Leppert D,Kuhle J,Kim-Schulze S,Nahrendorf M,Kleinstiver BP,Probert F,Roussos P,Swirski FK,McAlpine CS
100-21 was used in Cell Culture to establish IL-3:IL-3RA as a glial-peripheral immune network that prompts immune cell recruitment to the CNS and worsens MS.
Tue Jul 11 00:00:00 UTC 2023
Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis.
Clinical and experimental pharmacology & physiology
Wang H,Zhang X,Liu Y,Zhang Y,Wang Y,Peng Y,Ding Y
100-21 was used in In vitro experiments to suggest that the diosmetin-7-O-glucoside can regulate EndMT through ER stress, at least in part via Src-dependent pathways.
Sun Oct 01 00:00:00 UTC 2023
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Journal of translational medicine
Qu Y,Zhai R,Wang D,Wang Z,Hou G,Wu C,Tang M,Xiao X,Jiao J,Ba Y,Zhou F,Qiu J,Yao W
100-21 was used in Cell Culture to suggest that mitochondrial folate pathway regulates myofibroblast differentiation and could serve as a potential target for ameliorating silica-induced pulmonary fibrosis.
Tue Jun 06 00:00:00 UTC 2023
Generation and characterization of NGLY1 patient-derived midbrain organoids.
Frontiers in cell and developmental biology
Abbott J,Tambe M,Pavlinov I,Farkhondeh A,Nguyen HN,Xu M,Pradhan M,York T,Might M,Baumgärtel K,Rodems S,Zheng W
100-21 was used in Cell Culture to provide a relevant NGLY1 disease model to investigate disease mechanisms and evaluate therapeutics for treatments of NGLY1 deficiency.
Tue Mar 07 00:00:00 UTC 2023
Exposure to oxLDL impairs TGF-β activity in human tendon cells.
BMC musculoskeletal disorders
Mousavizadeh R,Waugh CM,DeBruin E,McCormack RG,Duronio V,Scott A
100-21 was used in Cell Culture to discover novel mechanistic effects of oxidized LDL on tendon cells and the mediators regulating matrix remodelling by analysing the expression and activity of related proteins and enzymes.
Thu Mar 16 00:00:00 UTC 2023
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.
Stem cell research & therapy
Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H
100-21 was used in Cell Culture to provides not only a potential therapeutic target for the treatment of allergic conjuctivitis (AC) but also other T cell-mediated diseases.
Mon Oct 02 00:00:00 UTC 2023
Invasion and Secondary Site Colonization as a Function of In Vitro Primary Tumor Matrix Stiffness: Breast to Bone Metastasis.
Advanced healthcare materials
Shah L,Latif A,Williams KJ,Mancuso E,Tirella A
100-21 was used in Cell Culture to understand the causal effect of primary tumor stiffness on metastatic potential, a new breast-to-bone in vitro model is described.
Sun Jan 01 00:00:00 UTC 2023
Chondrogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Steam Sterilized Gelatin/Chitosan/Polyvinyl Alcohol Hydrogels.
Polymers
Pérez-Díaz MA,Martínez-Colin EJ,González-Torres M,Ortega-Sánchez C,Sánchez-Sánchez R,Delgado-Meza J,Machado-Bistraín F,Martínez-López V,Giraldo D,Márquez-Gutiérrez ÉA,Jiménez-Ávalos JA,García-Carvajal ZY,Melgarejo-Ramírez Y
100-21 was used in In vitro experiments to support the biocompatibility of AD-hMSC onto steam-sterilized GE/CS/PVA hydrogels and its improved potential for chondrocyte differentiation.
Fri Sep 29 00:00:00 UTC 2023
Protocol for capturing trophectoderm stem cells reflecting the blastocyst stage.
STAR protocols
Seong J,Rivron NC
100-21 was used in Cell Culture to captures trophectoderm stem cells with enhanced transcriptomic similarity to the blastocyst trophectoderm and self-renewal, reduced differentiation.
Thu Mar 16 00:00:00 UTC 2023
Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells.
Cancers
Monti N,Dinicola S,Querqui A,Fabrizi G,Fedeli V,Gesualdi L,Catizone A,Unfer V,Bizzarri M
100-21 was used in In vitro experiments to demonstrate the capability of myo-inositol (myo-Ins) to revert the pithelial-Mesenchymal Transition process induced by TGF-β1 on MCF-10A breast cells.
Sat Apr 15 00:00:00 UTC 2023
Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation.
Antioxidants (Basel, Switzerland)
Kim J,Lee J,Yoon D,Son M,Kim MJ,Ha S,Kim D,Yoo JA,Kim D,Chung HY,Moon HR,Chung KW
100-21 was used in Cell Culture to investigate the potential of the thiobarbiturate-derived compound MHY1025 to alleviate chronic kidney disease by reducing oxidative stress and inflammatory responses.
Tue Oct 31 00:00:00 UTC 2023
Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.
Cell death & disease
Du Y,Shang Y,Qian Y,Guo Y,Chen S,Lin X,Cao W,Tang X,Zhou A,Huang S,Zhang A,Jia Z,Zhang Y
100-21 was used in In vitro experiments to show that Polo-like kinase 1 (Plk1) was upregulated in the kidneys of chronic kidney disease patients and mice subjected to unilateral ureteral obstruction (UUO) with location in proximal tubules and tubulointerstitial fibroblasts.
Tue Aug 29 00:00:00 UTC 2023
Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.
Cell death & disease
Du Y,Shang Y,Qian Y,Guo Y,Chen S,Lin X,Cao W,Tang X,Zhou A,Huang S,Zhang A,Jia Z,Zhang Y
100-21 was used in In vitro experiments to show that Polo-like kinase 1 (Plk1) was upregulated in the kidneys of chronic kidney disease patients and mice subjected to unilateral ureteral obstruction (UUO) with location in proximal tubules and tubulointerstitial fibroblasts.
Tue Aug 29 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
100-21 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Cancer discovery
Khan AO,Rodriguez-Romera A,Reyat JS,Olijnik AA,Colombo M,Wang G,Wen WX,Sousos N,Murphy LC,Grygielska B,Perrella G,Mahony CB,Ling RE,Elliott NE,Karali CS,Stone AP,Kemble S,Cutler EA,Fielding AK,Croft AP,Bassett D,Poologasundarampillai G,Roy A,Gooding S,Rayes J,Machlus KR,Psaila B
100-21 was used in In vitro experiments to present a human bone marrow organoid that supports the growth of primary cells from patients with myeloid and lymphoid blood cancers.
Mon Feb 06 00:00:00 UTC 2023
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
Frontiers in cellular neuroscience
Zhang W,Zhao X,Qi X,Kimber SJ,Hooper NM,Wang T
100-21 was used in Cell Culture to establish induced pluripotent stem cell (iPSC) models from Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy patients and differentiated the iPSCs into the major neurovascular unit cell types including brain microvascular endothelial-like cells (BMECs), vascular mural cells (MCs), astrocytes and cortical projection neurons.
Wed Feb 14 00:00:00 UTC 2024
Acidity-mediated induction of FoxP3+ regulatory T cells.
European journal of immunology
Rao D,Stunnenberg JA,Lacroix R,Dimitriadis P,Kaplon J,Verburg F,van van Royen PT,Hoefsmit EP,Renner K,Blank CU,Peeper DS
100-21 was used in Sample Preparation (FC/FACS) to conclude that acidity augments Treg induction and propose that therapeutic targeting of acidity in the tumor microenvironment (TME) might reduce Treg-mediated immune suppression within tumors.
Thu Jun 01 00:00:00 UTC 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
100-21 was used in Cell Culture to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 UTC 2023
Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway.
Pharmaceutical biology
Lin P,Qiu F,Wu M,Xu L,Huang D,Wang C,Yang X,Ye C
100-21 was used in Cell Culture to investigate the effect of Salvianolic acid B on renal tubulointerstitial fibrosis and explore its underlying mechanisms.
Fri Dec 01 00:00:00 UTC 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
100-21 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 UTC 2023
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.
Science advances
Riera-Domingo C,Leite-Gomes E,Charatsidou I,Zhao P,Carrá G,Cappellesso F,Mourao L,De Schepper M,Liu D,Serneels J,Alameh MG,Shuvaev VV,Geukens T,Isnaldi E,Prenen H,Weissman D,Muzykantov VR,Soenen S,Desmedt C,Scheele CLGJ,Sablina A,Di Matteo M,Martín-Pérez R,Mazzone M
100-21 was used in In vitro experiments to find that ECs at the PMN coexpress tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5).
Wed Mar 22 00:00:00 UTC 2023
Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis.
Respiratory research
Huang WC,Chuang CF,Huang YT,Chung IC,Chen ML,Chuang TY,Yang XL,Chou YY,Liu CH,Chen NY,Chen CJ,Yuan TT
100-21 was used in In vitro experiments to suggest multi-faceted roles of cell surface ENO1 and a potential therapeutic approach for pulmonary fibrosis.
Tue Nov 14 00:00:00 UTC 2023
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
Immunology
Zhang H,Pan B,Huang W,Ma M,Zhang F,Jiang L,Qian C,Wan X,Cao C
100-21 was used in Cell Culture to demonstrate that IKKα aggravated renal fibrogenesis by activating Wnt/β-catenin signalling pathway, providing a new target for the treatment of kidney fibrosis.
Sun Jan 01 00:00:00 UTC 2023
YTHDF2/m6 A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs.
The EMBO journal
Zhang L,Dou X,Zheng Z,Ye C,Lu TX,Liang HL,Wang L,Weichselbaum RR,He C
100-21 was used in Cell Culture to discover that the loss of YTHDF2 in regulatory T (Treg) cells reduces tumour growth in mice.
Tue Aug 01 00:00:00 UTC 2023
Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer.
Journal of experimental & clinical cancer research : CR
Kong D,Ye C,Zhang C,Sun X,Wang F,Chen R,Xiao G,He S,Xu J,Rao X,Ai J,Gao X,Li H,Su L
100-21 was used in Cell Culture to provide a drug screening strategy based on the cancer-host microenvironment and demonstrate that Procoxacin effectively inhibits both osteoblastic and osteoclastic lesions in prostate cancer-involved bones, which makes it a promising therapeutic agent for prostate cancer bone metastasis.
Thu Feb 09 00:00:00 UTC 2023
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
Signal transduction and targeted therapy
Wang Z,Zeng FL,Hu YW,Wang XY,Zhao FL,Zhou P,Hu J,Xiao YY,Hu ZL,Guo MF,Wei XQ,Liu X,Huang NY,Zhang J,Chen SW,Cheng J,Zheng HP,Zhou H,Zhao QX,Zhang C,Hao Y,Zou S,Gui YY,Yu JD,Gu LN,Yue CC,Zhang HZ,Wu WL,Zhou YF,Zhou XK,Shen GB,Teng X,Li J
Thu Jan 20 00:00:00 UTC 2022
Tissue Engineering with Mechanically Induced Solid-Fluid Transitions.
Advanced materials (Deerfield Beach, Fla.)
Mailand E,Özelçi E,Kim J,Rüegg M,Chaliotis O,Märki J,Bouklas N,Sakar MS
Sat Jan 01 00:00:00 UTC 2022
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Nature cell biology
Kathiriya JJ,Wang C,Zhou M,Brumwell A,Cassandras M,Le Saux CJ,Cohen M,Alysandratos KD,Wang B,Wolters P,Matthay M,Kotton DN,Chapman HA,Peng T
Sat Jan 01 00:00:00 UTC 2022
Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
EMBO molecular medicine
Letizia M,Wang YH,Kaufmann U,Gerbeth L,Sand A,Brunkhorst M,Weidner P,Ziegler JF,Böttcher C,Schlickeiser S,Fernández C,Yamashita M,Stauderman K,Sun K,Kunkel D,Prakriya M,Sanders A,Siegmund B,Feske S,Weidinger C
100-21 was used in Sample Preparation (FC/FACS) to indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.
Wed Sep 07 00:00:00 UTC 2022
SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.
Oncogene
Frey P,Devisme A,Rose K,Schrempp M,Freihen V,Andrieux G,Boerries M,Hecht A
Tue Feb 01 00:00:00 UTC 2022
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.
Cell proliferation
Li T,Lu H,Zhou L,Jia M,Zhang L,Wu H,Shan L
Fri Apr 01 00:00:00 UTC 2022
NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.
International journal of cancer
Borst L,Sluijter M,Sturm G,Charoentong P,Santegoets SJ,van Gulijk M,van Elsas MJ,Groeneveldt C,van Montfoort N,Finotello F,Trajanoski Z,Kiełbasa SM,van der Burg SH,van Hall T
Tue Feb 15 00:00:00 UTC 2022
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Development (Cambridge, England)
Vrij EJ,Scholte Op Reimer YS,Roa Fuentes L,Misteli Guerreiro I,Holzmann V,Frias Aldeguer J,Sestini G,Koo BK,Kind J,van Blitterswijk CA,Rivron NC
100-21 was used in Cell Culture to create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn) to suggest that self-organization can arise from lineage bifurcation followed by a pendulum of induction that propagates over time.
Sat Oct 15 00:00:00 UTC 2022
Salvianolic acid B acts against non‑small cell lung cancer A549 cells via inactivation of the MAPK and Smad2/3 signaling pathways.
Molecular medicine reports
Han G,Wang Y,Liu T,Gao J,Duan F,Chen M,Yang Y,Wu C
100-21 was used in Cell Culture to investigate effects of salvianolic acid B on cancer progression, and its molecular interactions.
Sun May 01 00:00:00 UTC 2022
SAHA could inhibit TGF-β1/p38 pathway in MI-induced cardiac fibrosis through DUSP4 overexpression.
Heart and vessels
Wang K,Tang R,Wang S,Wang W,Zhang K,Li J,Li P,Tang YD
100-21 was used in In vitro experiments to evaluate if SAHA could suppress cardiac fibrosis, by treating mice with MI-induced cardiac fibrosis with SAHA by intraperitoneal injection. Results of western blotting and qRT-PCR in heart tissues suggested that TGFβ1/P38 pathway was activated in MI mice, and this effect was reversed by SAHA. Cell proliferation assay suggested that SAHA could suppress TGF-β1-induced cardiac fibroblasts proliferation.
Sat Jan 01 00:00:00 UTC 2022
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.
Cell reports
Levy S,Somasundaram L,Raj IX,Ic-Mex D,Phal A,Schmidt S,Ng WI,Mar D,Decarreau J,Moss N,Alghadeer A,Honkanen H,Sarthy J,Vitanza A,Hawkins RD,Mathieu J,Wang Y,Baker D,Bomsztyk K,Ruohola-Baker H
100-21 was used in Cell Culture to identify a PRC2-controlled, functional TATA box >500 bp upstream of the TBX18 transcription start site (TSS) using EBdCas9.
Tue Mar 01 00:00:00 UTC 2022
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nature communications
Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A
100-21 was used in Competition Assay to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.
Mon Jul 18 00:00:00 UTC 2022
Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells.
Communications biology
Quicke P,Sun Y,Arias-Garcia M,Beykou M,Acker CD,Djamgoz MBA,Bakal C,Foust AJ
100-21 was used in Cell Culture to suggest that the ability to generate Vm fluctuations may be a property of hybrid epithelial-mesenchymal cells or those originated from luminal progenitors.
Fri Nov 11 00:00:00 UTC 2022
DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.
Brain : a journal of neurology
Cheng F,Zheng W,Barbuti PA,Bonsi P,Liu C,Casadei N,Ponterio G,Meringolo M,Admard J,Dording CM,Yu-Taeger L,Nguyen HP,Grundmann-Hauser K,Ott T,Houlden H,Pisani A,Krüger R,Riess O
100-21 was used in Cell Culture to characterize the function of THAP1 and contributes to the understanding of the pathogenesis of primary dystonia in humans and rats.
Mon Nov 21 00:00:00 UTC 2022
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Cell metabolism
Hochrein SM,Wu H,Eckstein M,Arrigoni L,Herman JS,Schumacher F,Gerecke C,Rosenfeldt M,Grün D,Kleuser B,Gasteiger G,Kastenmüller W,Ghesquière B,Van den Bossche J,Abel ED,Vaeth M
100-21 was used in In vitro experiments to show that GLUT3-dependent glucose uptake controls a metabolic-transcriptional circuit that regulates the pathogenicity of Th17 cells.
Tue Apr 05 00:00:00 UTC 2022
Inhibition of renal fibrosis with a human CXCL9-derived glycosaminoglycan-binding peptide.
Clinical & translational immunology
Poosti F,Soebadi MA,Crijns H,De Zutter A,Metzemaekers M,Berghmans N,Vanheule V,Albersen M,Opdenakker G,Van Damme J,Sprangers B,Proost P,Struyf S
Sun May 01 00:00:00 UTC 2022
Type XXVIII Collagen Regulates Renal Interstitial Fibrosis and Epithelial-Mesenchymal Transition by SREBP1-Mediated HKDC1 Expression.
Journal of the renin-angiotensin-aldosterone system : JRAAS
Li L,Zou Q,Li B,Huang L,Wei L
100-21 was used in Cell Culture to analyze the differential expression of genes in the stable COL28 overexpression HK-2 cell lines by RNA-sequencing analysis.
Mon Dec 19 00:00:00 UTC 2022
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
eLife
Jairaman A,McQuade A,Granzotto A,Kang YJ,Chadarevian JP,Gandhi S,Parker I,Smith I,Cho H,Sensi SL,Othy S,Blurton-Jones M,Cahalan MD
100-21 was used in In vitro experiments to show that loss of TREM2 confers a defect in microglial Ca2+ response to purinergic signals, suggesting a window of Ca2+ signaling for optimal microglial motility.
Tue Feb 22 00:00:00 UTC 2022
Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo.
Science advances
Cheng F,Zheng W,Liu C,Barbuti PA,Yu-Taeger L,Casadei N,Huebener-Schmid J,Admard J,Boldt K,Junger K,Ueffing M,Houlden H,Sharma M,Kruger R,Grundmann-Hauser K,Ott T,Riess O
100-21 was used in Cell Culture to identify that the DYT6 gene product THAP1 (THAP domain-containing apoptosis-associated protein 1) and its interaction partner CTCF (CCCTC-binding factor) act as transcription regulators of SNCA.
Fri Nov 25 00:00:00 UTC 2022
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Cell reports
Dudek M,Lohr K,Donakonda S,Baumann T,Lüdemann M,Hegenbarth S,Dübbel L,Eberhagen C,Michailidou S,Yassin A,Prinz M,Popper B,Rose-John S,Zischka H,Knolle PA
100-21 was used in Cell Culture to report that high-level mitochondrial respiration and constitutive low-level glycolysis support LSEC scavenger and sentinel functions.
Tue Feb 15 00:00:00 UTC 2022
Long Non-Coding RNA MIR31HG Promotes the Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma Cells.
International journal of molecular sciences
Ko CC,Hsieh YY,Yang PM
100-21 was used in In vitro experiments to analyse the effects of MIR31HG overexpression on the correlation of the survival of pancreatic ductal adenocarcinoma patients.
Sun Jun 12 00:00:00 UTC 2022
Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis.
The Journal of pathology
Chan KK,Hon TC,Au KY,Choi HL,Wong DK,Chan AC,Yuen MF,Lai CL,Lo RC
100-21 was used in In vitro experiments to show that the serum STC1 level in chronic hepatitis B patients was positively correlated with the degree of liver fibrosis and showed a stepwise increase in accordance with the severity of fibrosis.
Wed Jun 01 00:00:00 UTC 2022
Scalable Generation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Methods in molecular biology (Clifton, N.J.)
Hamad S,Derichsweiler D,Hescheler J,Pfannkuche K
100-21 was used in Cell Culture to describe a refined protocol for scalable generation of hiPSC-CMs that manipulates porcupine and tankyrase sub-pathways of Wnt signaling for tight inhibition of non-canonical Wnt signaling.
Thu Jun 23 00:00:00 UTC 2022
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl- concentration.
British journal of pharmacology
Li XL,Liu J,Chen XS,Cheng LM,Liu WL,Chen XF,Li YJ,Guan YY,Zeng X,Du YH
100-21 was used in In vitro experiments to examine whether transmembrane member 16A (TMEM16A), a Ca2+ -activated chloride channel, contributes to the progression of renal fibrosis.
Wed Jun 01 00:00:00 UTC 2022
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
The Journal of general physiology
Wang L,Noyer L,Wang YH,Tao AY,Li W,Zhu J,Saavedra P,Hoda ST,Yang J,Feske S
100-21 was used in In vitro experiments to investigate the plasma membrane protein ORAI3 function in immune cells in mice.
Mon Oct 03 00:00:00 UTC 2022
Dynamic regulation of myofibroblast phenotype in cellular senescence.
Aging cell
López-Antona I,Contreras-Jurado C,Luque-Martín L,Carpintero-Leyva A,González-Méndez P,Palmero I
100-21 was used in In vitro experiments to study the impact of senescence on the regulation of cell plasticity, focusing on the regulation of the myofibroblastic phenotype in primary fibroblasts.
Fri Apr 01 00:00:00 UTC 2022
Dynamic regulation of myofibroblast phenotype in cellular senescence.
Aging cell
López-Antona I,Contreras-Jurado C,Luque-Martín L,Carpintero-Leyva A,González-Méndez P,Palmero I
100-21 was used in In vitro experiments to study the impact of senescence on the regulation of cell plasticity, focusing on the regulation of the myofibroblastic phenotype in primary fibroblasts.
Fri Apr 01 00:00:00 UTC 2022
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
Viruses
Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I
100-21 was used in Sample Preparation (FC/FACS) to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.
Tue Oct 18 00:00:00 UTC 2022
Efficient TGF-β1 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes.
International journal of molecular sciences
Velot É,Elkhoury K,Kahn C,Kempf H,Linder M,Arab-Tehrany E,Bianchi A
100-21 was used in In vitro experiments to deliver encapsulated transforming growth factor (TGF-β1) to rat chondrocytes using agro-based rapeseed liposomes, which contains a high level of mono- and poly-unsaturated fatty acids.
Sat Mar 05 00:00:00 UTC 2022
SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4.
Communications biology
Bertrand-Chapel A,Caligaris C,Fenouil T,Savary C,Aires S,Martel S,Huchedé P,Chassot C,Chauvet V,Cardot-Ruffino V,Morel AP,Subtil F,Mohkam K,Mabrut JY,Tonon L,Viari A,Cassier P,Hervieu V,Castets M,Mauviel A,Sentis S,Bartholin L
100-21 was used in Sample Preparation (Western Blotting) to study the role of SMAD2/3 in pancreatic ductal adenocarcinoma (PDAC) using SMAD4 null human PDAC cancer cells.
Fri Oct 07 00:00:00 UTC 2022
Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.
Glia
Usui-Ouchi A,Eade K,Giles S,Ideguchi Y,Ouchi Y,Aguilar E,Wei G,Marra KV,Berlow RB,Friedlander M
100-21 was used in Cell Culture to show that Tgfβ signaling in microglia is essential for microglial homeostasis and that the disruption of Tgfβ signaling in microglia exacerbates retinal NV in OIR by promoting leukostasis and Igf1 expression.
Thu Sep 01 00:00:00 UTC 2022
Recombinant truncated latency-associated peptide alleviates liver fibrosis in vitro and in vivo via inhibition of TGF-β/Smad pathway.
Molecular medicine (Cambridge, Mass.)
Song X,Shi J,Liu J,Liu Y,Yu Y,Qiu Y,Cao Z,Pan Y,Yuan X,Chu Y,Wu D
100-21 was used in In vitro experiments to provide new ideas for the treatment of liver fibrosis.
Sat Jul 16 00:00:00 UTC 2022
Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury.
British journal of pharmacology
Benitez R,Caro M,Andres-Leon E,O'Valle F,Delgado M
100-21 was used in Cell Culture to identify cortistatin as an endogenous molecular brake on liver fibrosis and its deficiency as a potential poor-prognosis marker for chronic hepatic disorders that link with fibrosis.
Sun May 01 00:00:00 UTC 2022
Evaluation of Glutaminolysis in T Cells.
Current protocols
Tajima M,Strober W
100-21 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.
Thu Sep 01 00:00:00 UTC 2022
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
Nature communications
Ramirez NP,Lee J,Zheng Y,Li L,Dennis B,Chen D,Challa A,Planelles V,Westover KD,Alto NM,D'Orso I
100-21 was used in Flow cytometry/Cell sorting to define ADAP1 as an unexpected tuner of T cell programs facilitating HIV-1 latency escape.
Tue Mar 01 00:00:00 UTC 2022
RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification.
Science advances
Tachibana N,Chijimatsu R,Okada H,Oichi T,Taniguchi Y,Maenohara Y,Miyahara J,Ishikura H,Iwanaga Y,Arino Y,Nagata K,Nakamoto H,Kato S,Doi T,Matsubayashi Y,Oshima Y,Terashima A,Omata Y,Yano F,Maeda S,Ikegawa S,Seki M,Suzuki Y,Tanaka S,Saito T
100-21 was used in Cell Culture to investigate the characteristics of Prg4-positive (+) cells and identified that R-spondin 2, a WNT activator, is specifically expressed in a distinct Prg4+ Tendon stem/progenitor cell cluster.
Fri Aug 19 00:00:00 UTC 2022
RNA -methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer.
Theranostics
Tan B,Zhou K,Liu W,Prince E,Qing Y,Li Y,Han L,Qin X,Su R,Pokharel SP,Yang L,Zhao Z,Shen C,Li W,Chen Z,Zhang Z,Deng X,Small A,Wang K,Leung K,Chen CW,Shen B,Chen J
100-21 was used in In vitro experiments to demonstrate that YTHDC1 is vital for TNBC progression by enhancing TNBC cell survival and TGF-β-mediated EMT via SMAD3 to enable the formation of distant metastasis and highlights the therapeutic potential of targeting the YTHDC1/m6A/SMAD3 axis for TNBC treatment.
Tue Aug 16 00:00:00 UTC 2022
Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations.
JCI insight
Kilari S,Wang Y,Singh A,Graham RP,Iyer V,Thompson SM,Torbenson MS,Mukhopadhyay D,Misra S
100-21 was used in Cell Culture to investigate genetic mutations in hemorrhagic telangictasia.
Mon May 09 00:00:00 UTC 2022
Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.
Frontiers in pharmacology
Xie S,Xu F,Lu Y,Zhang Y,Li X,Yu M,Cui W
100-21 was used in Cell Culture to stimulate human peritoneal mesothelial cell (HPMCs) using transforming growth factor-beta 1 (TGF-β1) in cell experiments performed in vitro.
Sat Jul 16 00:00:00 UTC 2022
Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication.
iScience
Froese N,Cordero J,Abouissa A,Trogisch FA,Grein S,Szaroszyk M,Wang Y,Gigina A,Korf-Klingebiel M,Bosnjak B,Davenport CF,Wiehlmann L,Geffers R,Riechert E,Jürgensen L,Boileau E,Lin Y,Dieterich C,Förster R,Bauersachs J,Ola R,Dobreva G,Völkers M,Heineke J
100-21 was used in Cell Culture to isolate cardiomyocytes, endothelial cells, and fibroblasts as most abundant cell types from mouse hearts in the subacute and chronic stages after transverse aortic constriction (TAC) and performe RNA-sequencing.
Fri Mar 18 00:00:00 UTC 2022
α-Catenin links integrin adhesions to F-actin to regulate ECM mechanosensing and rigidity dependence.
The Journal of cell biology
Mukherjee A,Melamed S,Damouny-Khoury H,Amer M,Feld L,Nadjar-Boger E,Sheetz MP,Wolfenson H
100-21 was used in In vitro experiments to show that α-catenin, a mechanosensitive protein that is classically linked with cadherin-based adhesions, associates with and regulates integrin adhesions.
Mon Aug 01 00:00:00 UTC 2022
A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.
Cell discovery
Karpf L,Trichot C,Faucheux L,Legbre I,Grandclaudon M,Lahoute C,Mattoo H,Pasquier B,Soumelis V
Tue Jan 04 00:00:00 UTC 2022
PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis.
JCI insight
Xu D,Bhattacharyya S,Wang W,Ifergan I,Wong MAC,Procissi D,Yeldandi A,Bale S,Marangoni RG,Horbinski C,Miller SD,Varga J
100-21 was used in In vitro experiments to show that MARCO+ monocytes are potent effector cells of skin and lung fibrosis and can be therapeutically targeted in systemic sclerosis (SSc) using PLG nanoparticles.
Tue Mar 08 00:00:00 UTC 2022
Mapping the cardiac vascular niche in heart failure.
Nature communications
Peisker F,Halder M,Nagai J,Ziegler S,Kaesler N,Hoeft K,Li R,Bindels EMJ,Kuppe C,Moellmann J,Lehrke M,Stoppe C,Schaub MT,Schneider RK,Costa I,Kramann R
100-21 was used in In vitro experiments to provide an extensive resource of transcriptomic changes in the vascular niche in hypertrophic cardiac remodeling.
Tue May 31 00:00:00 UTC 2022
Transcriptional response of murine microglia in Alzheimer's disease and inflammation.
BMC genomics
Shippy DC,Watters JJ,Ulland TK
100-21 was used in Sample Preparation (FC/FACS) to study the microglial gene networks to identify new targets for therapeutic strategies for Alzheimer's disease (AD).
Sat Mar 05 00:00:00 UTC 2022
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
Nature
Witkowski M,Tizian C,Ferreira-Gomes M,Niemeyer D,Jones TC,Heinrich F,Frischbutter S,Angermair S,Hohnstein T,Mattiola I,Nawrath P,McEwen S,Zocche S,Viviano E,Heinz GA,Maurer M,Kölsch U,Chua RL,Aschman T,Meisel C,Radke J,Sawitzki B,Roehmel J,Allers K,Moos V,Schneider T,Hanitsch L,Mall MA,Conrad C,Radbruch H,Duerr CU,Trapani JA,Marcenaro E,Kallinich T,Corman VM,Kurth F,Sander LE,Drosten C,Treskatsch S,Durek P,Kruglov A,Radbruch A,Mashreghi MF,Diefenbach A
100-21 was used in Cell Culture to investigate if a decline in viral load in COVID-19 correlates with Natural killer (NK) cell status and if NK cells can control SARS-CoV-2 replication by recognizing infected target cells.
Wed Dec 01 00:00:00 UTC 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
100-21 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 UTC 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
100-21 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 UTC 2021
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Nature
Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA
100-21 was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.
Thu Apr 01 00:00:00 UTC 2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
100-21 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 UTC 2021
Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.
Immunity
Golebski K,Layhadi JA,Sahiner U,Steveling-Klein EH,Lenormand MM,Li RCY,Bal SM,Heesters BA,Vilà-Nadal G,Hunewald O,Montamat G,He FQ,Ollert M,Fedina O,Lao-Araya M,Vijverberg SJH,Maitland-van der Zee AH,van Drunen CM,Fokkens WJ,Durham SR,Spits H,Shamji MH
Tue Feb 09 00:00:00 UTC 2021
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection.
Immunity
Gabriel SS,Tsui C,Chisanga D,Weber F,Llano-León M,Gubser PM,Bartholin L,Souza-Fonseca-Guimaraes F,Huntington ND,Shi W,Utzschneider DT,Kallies A
Tue Aug 10 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 UTC 2021
A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1.
Cell host & microbe
Li W,Hang S,Fang Y,Bae S,Zhang Y,Zhang M,Wang G,McCurry MD,Bae M,Paik D,Franzosa EA,Rastinejad F,Huttenhower C,Yao L,Devlin AS,Huh JR
Wed Sep 08 00:00:00 UTC 2021
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer.
Nature immunology
Osman A,Yan B,Li Y,Pavelko KD,Quandt J,Saadalla A,Singh MP,Kazemian M,Gounari F,Khazaie K
Wed Sep 01 00:00:00 UTC 2021
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity.
Nature immunology
Christo SN,Evrard M,Park SL,Gandolfo LC,Burn TN,Fonseca R,Newman DM,Alexandre YO,Collins N,Zamudio NM,Souza-Fonseca-Guimaraes F,Pellicci DG,Chisanga D,Shi W,Bartholin L,Belz GT,Huntington ND,Lucas A,Lucas M,Mueller SN,Heath WR,Ginhoux F,Speed TP,Carbone FR,Kallies A,Mackay LK
Wed Sep 01 00:00:00 UTC 2021
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Nature neuroscience
Kang Y,Zhou Y,Li Y,Han Y,Xu J,Niu W,Li Z,Liu S,Feng H,Huang W,Duan R,Xu T,Raj N,Zhang F,Dou J,Xu C,Wu H,Bassell GJ,Warren ST,Allen EG,Jin P,Wen Z
Fri Oct 01 00:00:00 UTC 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-21 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-21 was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Cell stem cell
Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH
Thu Sep 02 00:00:00 UTC 2021
Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.
International journal of oral science
Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y
Thu Sep 30 00:00:00 UTC 2021
Human skin is colonized by T cells that recognize CD1a independently of lipid.
The Journal of clinical investigation
Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB
Mon Jan 04 00:00:00 UTC 2021
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
The Journal of clinical investigation
Chen YT,Jhao PY,Hung CT,Wu YF,Lin SJ,Chiang WC,Lin SL,Yang KC
Mon Mar 01 00:00:00 UTC 2021
Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
Nucleic acids research
Khan M,Hou S,Azam S,Lei H
100-21 was used in Cell Culture to report the identification of a cytoplasmic accumulation region (CAR-N) in the intronless lncRNA, NKILA.
Mon Jun 21 00:00:00 UTC 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
100-21 was used in In vitro experiments to better understand the roles of intestinal epithelial cells.
Mon Apr 05 00:00:00 UTC 2021
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation.
The Journal of experimental medicine
Derakhshan T,Samuchiwal SK,Hallen N,Bankova LG,Boyce JA,Barrett NA,Austen KF,Dwyer DF
Mon Jan 04 00:00:00 UTC 2021
MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
The Journal of experimental medicine
Wigton EJ,Mikami Y,McMonigle RJ,Castellanos CA,Wade-Vallance AK,Zhou SK,Kageyama R,Litterman A,Roy S,Kitamura D,Dykhuizen EC,Allen CDC,Hu H,O'Shea JJ,Ansel KM
Mon Nov 01 00:00:00 UTC 2021
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
The Journal of experimental medicine
Kiuchi M,Onodera A,Kokubo K,Ichikawa T,Morimoto Y,Kawakami E,Takayama N,Eto K,Koseki H,Hirahara K,Nakayama T
Mon Apr 05 00:00:00 UTC 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 UTC 2021
Liver Sinusoidal Endothelial Cells Suppress Bone Morphogenetic Protein 2 Production in Response to TGFβ Pathway Activation.
Hepatology (Baltimore, Md.)
Colucci S,Altamura S,Marques O,Dropmann A,Horvat NK,Müdder K,Hammad S,Dooley S,Muckenthaler MU
Fri Oct 01 00:00:00 UTC 2021
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain : a journal of neurology
Magusali N,Graham AC,Piers TM,Panichnantakul P,Yaman U,Shoai M,Reynolds RH,Botia JA,Brookes KJ,Guetta-Baranes T,Bellou E,Bayram S,Sokolova D,Ryten M,Sala Frigerio C,Escott-Price V,Morgan K,Pocock JM,Hardy J,Salih DA
Fri Dec 31 00:00:00 UTC 2021
WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.
Molecular psychiatry
Wang M,Tang C,Xing R,Liu X,Han X,Liu Y,Wang L,Yang C,Guo W
Mon Feb 01 00:00:00 UTC 2021
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition.
Developmental cell
Price CJ,Stavish D,Gokhale PJ,Stevenson BA,Sargeant S,Lacey J,Rodriguez TA,Barbaric I
Mon Sep 13 00:00:00 UTC 2021
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.
Autophagy
Yang G,Song W,Postoak JL,Chen J,Martinez J,Zhang J,Wu L,Van Kaer L
100-21 was used in Cell Culture to study the contribution of PIK3C3 to T cell metabolism and function to show that Pik3c3-deficient T cells exhibit impaired cellular metabolism, and that Pik3c3-deficient CD4+ T cells fail to differentiate into T helper 1 cells, changes which are associated with reduced levels of active mitochondria upon T cell activation.
Sat May 01 00:00:00 UTC 2021
Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche.
Proceedings of the National Academy of Sciences of the United States of America
Hupfer A,Brichkina A,Koeniger A,Keber C,Denkert C,Pfefferle P,Helmprobst F,Pagenstecher A,Visekruna A,Lauth M
Tue Oct 05 00:00:00 UTC 2021
Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche.
Proceedings of the National Academy of Sciences of the United States of America
Hupfer A,Brichkina A,Koeniger A,Keber C,Denkert C,Pfefferle P,Helmprobst F,Pagenstecher A,Visekruna A,Lauth M
Tue Oct 05 00:00:00 UTC 2021
Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Hao F,Tian M,Zhang X,Jin X,Jiang Y,Sun X,Wang Y,Peng P,Liu J,Xia C,Feng Y,Wei M
Tue Jun 01 00:00:00 UTC 2021
Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
Proceedings of the National Academy of Sciences of the United States of America
Ducimetière L,Lucchiari G,Litscher G,Nater M,Heeb L,Nuñez NG,Wyss L,Burri D,Vermeer M,Gschwend J,Moor AE,Becher B,van den Broek M,Tugues S
Tue Jul 06 00:00:00 UTC 2021
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.
Experimental & molecular medicine
Du F,Qi X,Zhang A,Sui F,Wang X,Proud CG,Lin C,Fan X,Li J
Wed Sep 01 00:00:00 UTC 2021
The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells.
Cancer immunology research
Paavola KJ,Roda JM,Lin VY,Chen P,O'Hollaren KP,Ventura R,Crawley SC,Li B,Chen HH,Malmersjö S,Sharkov NA,Horner G,Guo W,Kutach AK,Mondal K,Zhang Z,Lichtman JS,Song C,Rivera LB,Liu W,Luo J,Wang Y,Solloway MJ,Allan BB,Kekatpure A,Starck SR,Haldankar R,Fan B,Chu C,Tang J,Molgora M,Colonna M,Kaplan DD,Hsu JY
100-21 was used in In vitro experiments to show that, by blocking this interaction, tumor-associated myeloid cells may acquire a stimulatory phenotype, potentially resulting in increased antitumor T-cell responses.
Mon Nov 01 00:00:00 UTC 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
Fri Jan 01 00:00:00 UTC 2021
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption.
Current biology : CB
Adams SD,Csere J,D'angelo G,Carter EP,Romao M,Arnandis T,Dodel M,Kocher HM,Grose R,Raposo G,Mardakheh F,Godinho SA
Mon Apr 12 00:00:00 UTC 2021
RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis.
Angiogenesis
Gao S,Griffin CT
100-21 was used in In vitro experiments to study the potential role of receptor-interacting protein kinase 3 (RIPK3) in angiogenesis to reveal unexpected non-necroptotic roles for RIPK3 in endothelial cells (ECs) and evidence that RIPK3 promotes developmental angiogenesis in vivo.
Sun Aug 01 00:00:00 UTC 2021
IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kawai K,Uchiyama M,Hester J,Issa F
Mon Mar 01 00:00:00 UTC 2021
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
Glia
Parajuli B,Saito H,Shinozaki Y,Shigetomi E,Miwa H,Yoneda S,Tanimura M,Omachi S,Asaki T,Takahashi K,Fujita M,Nakashima K,Koizumi S
Fri Oct 01 00:00:00 UTC 2021
Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.
Glia
Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E
Mon Mar 01 00:00:00 UTC 2021
Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.
Stem cells translational medicine
Yamashita A,Yoshitomi H,Kihara S,Toguchida J,Tsumaki N
Fri Jan 01 00:00:00 UTC 2021
Small extracellular vesicles deliver TGF-β1 and promote adriamycin resistance in breast cancer cells.
Molecular oncology
Tan C,Sun W,Xu Z,Zhu S,Hu W,Wang X,Zhang Y,Zhang G,Wang Z,Xu Y,Tang J
Sat May 01 00:00:00 UTC 2021
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Oxidative medicine and cellular longevity
Zhang M,Luo C,Lin D,Cui K,Chen Z,Liu J
Fri Nov 12 00:00:00 UTC 2021
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Oxidative medicine and cellular longevity
Su X,Yang Y,Guo C,Zhang R,Sun S,Wang Y,Qiao Q,Fu Y,Pang Q
Wed Jan 05 00:00:00 UTC 2022
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Oxidative medicine and cellular longevity
Su X,Yang Y,Guo C,Zhang R,Sun S,Wang Y,Qiao Q,Fu Y,Pang Q
Wed Jan 05 00:00:00 UTC 2022
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
100-21 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 UTC 2021
Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway.
Journal of inflammation (London, England)
Ebrahimpour A,Wang M,Li L,Jegga AG,Bonnen MD,Eissa NT,Raghu G,Jyothula S,Kheradmand F,Hanania NA,Rosas IO,Ghebre YT
100-21 was used in Cell Culture to investigate molecular mechanism(s) by which proton pump inhibitors favorably regulate the process of idiopathic pulmonary fibrosis.
Wed May 19 00:00:00 UTC 2021
Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.
Frontiers in cell and developmental biology
Wu X,Dong W,Kong M,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X
100-21 was used in Cell Culture to unveil a novel transcriptional mechanism contributing to HSC activation and liver fibrosis.
Sat Oct 09 00:00:00 UTC 2021
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells.
Stem cells (Dayton, Ohio)
Mishra S,Taelman J,Popovic M,Tilleman L,Duthoo E,van der Jeught M,Deforce D,van Nieuwerburgh F,Menten B,de Sutter P,Boel A,Chuva De Sousa Lopes SM,Heindryckx B
Sat May 01 00:00:00 UTC 2021
Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1-/- ) mice affects the skin wound healing process.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Machcinska S,Kopcewicz M,Bukowska J,Walendzik K,Gawronska-Kozak B
Mon Feb 01 00:00:00 UTC 2021
Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jiang Y,Xie F,Lv X,Wang S,Liao X,Yu Y,Dai Q,Zhang Y,Meng J,Hu G,Peng Z,Tao L
Fri Jan 01 00:00:00 UTC 2021
Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jiang Y,Xie F,Lv X,Wang S,Liao X,Yu Y,Dai Q,Zhang Y,Meng J,Hu G,Peng Z,Tao L
Fri Jan 01 00:00:00 UTC 2021
Modulation of microRNA processing by 5-lipoxygenase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Uebbing S,Kreiß M,Scholl F,Häfner AK,Sürün D,Garscha U,Werz O,Basavarajappa D,Samuelsson B,Rådmark O,Suess B,Steinhilber D
Mon Feb 01 00:00:00 UTC 2021
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.
The American journal of pathology
O'Hare M,Amarnani D,Whitmore HAB,An M,Marino C,Ramos L,Delgado-Tirado S,Hu X,Chmielewska N,Chandrahas A,Fitzek A,Heinrich F,Steurer S,Ondruschka B,Glatzel M,Krasemann S,Sepulveda-Falla D,Lagares D,Pedron J,Bushweller JH,Liu P,Arboleda-Velasquez JF,Kim LA
Thu Jul 01 00:00:00 UTC 2021
Transforming Growth Factor-Beta-Regulated LncRNA-MUF Promotes Invasion by Modulating the miR-34a Snail1 Axis in Glioblastoma Multiforme.
Frontiers in oncology
Shree B,Tripathi S,Sharma V
100-21 was used in Cell Culture to suggest lncRNA-MUF as an attractive therapeutic target for GBM.
Tue Mar 01 00:00:00 UTC 2022
Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus.
Journal of immunology (Baltimore, Md. : 1950)
Sonoda S,Murata S,Kato H,Zakaria F,Kyumoto-Nakamura Y,Uehara N,Yamaza H,Kukita T,Yamaza T
Tue Jun 15 00:00:00 UTC 2021
Layilin Anchors Regulatory T Cells in Skin.
Journal of immunology (Baltimore, Md. : 1950)
Mehta P,Gouirand V,Boda DP,Zhang J,Gearty SV,Zirak B,Lowe MM,Clancy S,Boothby I,Mahuron KM,Fries A,Krummel MF,Mankoo P,Chang HW,Liu J,Moreau JM,Scharschmidt TC,Daud A,Kim E,Neuhaus IM,Harris HW,Liao W,Rosenblum MD
Fri Oct 01 00:00:00 UTC 2021
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Journal of cellular and molecular medicine
Yu Q,Cheng P,Wu J,Guo C
Mon Feb 01 00:00:00 UTC 2021
TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners.
Journal of cellular and molecular medicine
Zou LL,Li JR,Li H,Tan JL,Wang MX,Liu NN,Gao RM,Yan HY,Wang XK,Dong B,Li YH,Peng ZG
Thu Apr 01 00:00:00 UTC 2021
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Journal of cellular and molecular medicine
Song Z,Wu T,Sun J,Wang H,Hua F,Nicolas YSM,Kc R,Chen K,Jin Z,Liu J,Zhang M
Thu Apr 01 00:00:00 UTC 2021
Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model.
Stem cells international
Chang YH,Ding DC,Wu KC
Tue Nov 02 00:00:00 UTC 2021
Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.
Stem cells international
Lee Y,Park YS,Choi NY,Kim YI,Koh YG
Tue Jul 27 00:00:00 UTC 2021
Notch2 suppression mimicking changes in human pulmonary hypertension modulates Notch1 and promotes endothelial cell proliferation.
American journal of physiology. Heart and circulatory physiology
Sahoo S,Li Y,de Jesus D,Sembrat J,Rojas MM,Goncharova E,Cifuentes-Pagano E,Straub AC,Pagano PJ
Wed Sep 01 00:00:00 UTC 2021
Assessment of Allergen-Responsive Regulatory T Cells in Experimental Asthma Induced in Different Mouse Strains.
Mediators of inflammation
Azevedo CT,Cotias AC,Arantes ACS,Ferreira TPT,Martins MA,Olsen PC
Mon Mar 28 00:00:00 UTC 2022
HMGA2-induced epithelial-mesenchymal transition is reversed by let-7d in intrauterine adhesions.
Molecular human reproduction
Song M,Cao C,Zhou Z,Yao S,Jiang P,Wang H,Zhao G,Hu Y
100-21 was used in Cell Culture to study the pathogenesis of intrauterine adhesions (IUAs) to understand how it could be managed and reveal that high mobility group AT-hook 2 (HMGA2) promotes IUA formation which could be targeted for clinical management of IUA.
Fri Feb 05 00:00:00 UTC 2021
Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation.
Journal of immunology research
Yan W,Zhao YS,Xie K,Xing Y,Xu F
Wed Dec 15 00:00:00 UTC 2021
HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation.
Journal of immunology research
Yu S,Tripod M,Atasoy U,Chen J
Mon Jan 10 00:00:00 UTC 2022
Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration.
Physiological genomics
Parrish A,Srivastava A,Juskeviciute E,Hoek JB,Vadigepalli R
Wed Dec 01 00:00:00 UTC 2021
The expression of tenascin-C in neural stem/progenitor cells is stimulated by the growth factors EGF and FGF-2, but not by TGFβ1.
Cell and tissue research
Theocharidis U,Roll L,Faissner A
100-21 was used in Cell Culture to evaluate the use of neural stem/progenitor cells to regulate Tnc gene expression under the influence of different growth factors.
Wed Sep 01 00:00:00 UTC 2021
Cell sheet technology: Influence of culture conditions on in vitro-cultivated corneal stromal tissue for regenerative therapies of the ocular surface.
Journal of biomedical materials research. Part B, Applied biomaterials
Hasenzahl M,Müsken M,Mertsch S,Schrader S,Reichl S
Fri Oct 01 00:00:00 UTC 2021
Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1.
BioMed research international
Sun M,Zhuang X,Lv G,Lin Z,Huang X,Zhao J,Lin H,Wang Y
Wed Jan 19 00:00:00 UTC 2022
FTZ Ameliorates Diabetic Cardiomyopathy by Inhibiting Inflammation and Cardiac Fibrosis in the Streptozotocin-Induced Model.
Evidence-based complementary and alternative medicine : eCAM
Wang L,Wu H,Deng Y,Zhang S,Wei Q,Yang Q,Piao S,Bei W,Rong X,Guo J
Wed Apr 27 00:00:00 UTC 2022
Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration.
Communications biology
Herberg S,Varghai D,Alt DS,Dang PN,Park H,Cheng Y,Shin JY,Dikina AD,Boerckel JD,Rolle MW,Alsberg E
Tue Jan 19 00:00:00 UTC 2021
Broadly active zinc finger protein-guided transcriptional activation of HIV-1.
Molecular therapy. Methods & clinical development
Scott TA,O'Meally D,Grepo NA,Soemardy C,Lazar DC,Zheng Y,Weinberg MS,Planelles V,Morris KV
Fri Mar 12 00:00:00 UTC 2021
The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis.
Cells
Henderson J,Dayalan Naidu S,Dinkova-Kostova AT,Przyborski S,Stratton R,O Reilly S
100-21 was used in In vitro experiments to study the role of the cell-permeable derivative of itaconate, 4-octyl itaconate (4-OI), in systemic sclerosis (SSc).
Tue Aug 10 00:00:00 UTC 2021
Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis.
The Journal of biological chemistry
Matsuzawa T,Morita M,Shimane A,Otsuka R,Mei Y,Irie F,Yamaguchi Y,Yanai K,Yoshikawa T
Wed Sep 01 00:00:00 UTC 2021
Direct and Indirect endocrine-mediated suppression of human endometrial CD8+T cell cytotoxicity.
Scientific reports
Shen Z,Rodriguez-Garcia M,Patel MV,Wira CR
Tue Jan 19 00:00:00 UTC 2021
PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR.
Cell reports
Ghosh S,Nataraj NB,Noronha A,Patkar S,Sekar A,Mukherjee S,Winograd-Katz S,Kramarski L,Verma A,Lindzen M,Garcia DD,Green J,Eisenberg G,Gil-Henn H,Basu A,Lender Y,Weiss S,Oren M,Lotem M,Geiger B,Ruppin E,Yarden Y
Tue May 25 00:00:00 UTC 2021
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Cell death & disease
Li Y,Zhang N,Ma C,Xu W,Jin G,Zheng Y,Zhang L,Liu B,Gao C,Liu S
Tue Oct 26 00:00:00 UTC 2021
Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair.
Communications biology
Molenaar B,Timmer LT,Droog M,Perini I,Versteeg D,Kooijman L,Monshouwer-Kloots J,de Ruiter H,Gladka MM,van Rooij E
Fri Jan 29 00:00:00 UTC 2021
Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation.
Scientific reports
Amamou A,Rouland M,Yaker L,Goichon A,Guérin C,Aziz M,Savoye G,Marion-Letellier R
Fri Jul 23 00:00:00 UTC 2021
An intermediate state in trans-differentiation with proliferation, metabolic, and epigenetic switching.
iScience
Ye Z,Li W,Jiang Z,Wang E,Wang J
Fri Sep 24 00:00:00 UTC 2021
Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development.
Cell reports
Zhang H,Dai D,Hu Q,Yang F,Xue Y,Li F,Shen N,Zhang M,Huang C
Tue May 11 00:00:00 UTC 2021
Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro.
The Journal of biological chemistry
Eisele BS,Luka Z,Wu AJ,Yang F,Hale AT,York JD
Mon Nov 01 00:00:00 UTC 2021
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
iScience
Morozzi G,Rothen J,Toussaint G,De Lange K,Westritschnig K,Doelemeyer A,Ueberschlag VP,Kahle P,Lambert C,Obrecht M,Beckmann N,Ritter V,Panesar M,Stauffer D,Garnier I,Mueller M,Guerini D,Keller CG,Knehr J,Roma G,Bidinosti M,Brachat S,Morvan F,Fornaro M
100-21 was used in In vitro experiments to investigate relationship between peripheral nerve injury and inflammation.
Fri Dec 17 00:00:00 UTC 2021
Development of an In Vitro Airway Epithelial-Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells.
Membranes
Pasman T,Baptista D,van Riet S,Truckenmüller RK,Hiemstra PS,Rottier RJ,Hamelmann NM,Paulusse JMJ,Stamatialis D,Poot AA
100-21 was used in Cell Culture to show that the model can form the basis for biomimetic airway epithelial-endothelial and alveolar-endothelial models with primary lung epithelial cells.
Thu Mar 11 00:00:00 UTC 2021
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Cell
Raghavan S,Winter PS,Navia AW,Williams HL,DenAdel A,Lowder KE,Galvez-Reyes J,Kalekar RL,Mulugeta N,Kapner KS,Raghavan MS,Borah AA,Liu N,Väyrynen SA,Costa AD,Ng RWS,Wang J,Hill EK,Ragon DY,Brais LK,Jaeger AM,Spurr LF,Li YY,Cherniack AD,Booker MA,Cohen EF,Tolstorukov MY,Wakiro I,Rotem A,Johnson BE,McFarland JM,Sicinska ET,Jacks TE,Sullivan RJ,Shapiro GI,Clancy TE,Perez K,Rubinson DA,Ng K,Cleary JM,Crawford L,Manalis SR,Nowak JA,Wolpin BM,Hahn WC,Aguirre AJ,Shalek AK
100-21 was used in In vitro experiments to study distinct site and state-specific tumour microevironments in pancreatic cancer.
Thu Dec 09 00:00:00 UTC 2021
αvβ3 Integrin induces partial EMT independent of TGF-β signaling.
Communications biology
Kariya Y,Oyama M,Suzuki T,Kariya Y
Wed Apr 21 00:00:00 UTC 2021
Protocol for intracellular and extracellular metabolite detection in human embryonic stem cells.
STAR protocols
Xu F,Song C,Liu W,Chen G
100-21 was used in Cell Culture to describe a procedure for both cell culture and detection of intracellular and extracellular metabolites in hESCs by liquid chromatography-mass spectrometry.
Fri Sep 17 00:00:00 UTC 2021
Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.
Scientific reports
Ishikawa S,Nishida N,Fujino S,Ogino T,Takahashi H,Miyoshi N,Uemura M,Satoh T,Yamamoto H,Mizushima T,Doki Y,Eguchi H
Thu Jun 03 00:00:00 UTC 2021
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses.
Nature communications
Deng J,Chen Q,Chen Z,Liang K,Gao X,Wang X,Makota FV,Ong HS,Wan Y,Luo K,Gong D,Yu X,Camuglia S,Zeng Q,Zhou T,Xue F,He J,Wei Y,Xiao F,Ma J,Hill DL,Pierson W,Nguyen THO,Zhou H,Wang Y,Shen W,Sun L,Li Z,Xia Q,Qian K,Ye L,Rockman S,Linterman MA,Kedzierska K,Shen N,Lu L,Yu D
Mon May 24 00:00:00 UTC 2021
BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs.
Stem cell research & therapy
Jin J,Ou Q,Wang Z,Tian H,Xu JY,Gao F,Hu S,Chen J,Wang J,Zhang J,Lu L,Jin C,Xu GT,Zhao J
100-21 was used in Cell Culture to investigate development of skin cells and bone-marrow mesenchymal stem cells in systemic sclerosis.
Sat Jun 05 00:00:00 UTC 2021
RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2.
Cell death discovery
Zhang J,Chen H,Weng X,Liu H,Chen Z,Huang Q,Wang L,Liu X
Wed Oct 27 00:00:00 UTC 2021
The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.
Cell death & disease
He C,Li A,Lai Q,Ding J,Yan Q,Liu S,Li Q
Tue Jan 12 00:00:00 UTC 2021
Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling.
Cancer medicine
Jia M,Wang Y,Guo Y,Yu P,Sun Y,Song Y,Zhao L
Sat May 01 00:00:00 UTC 2021
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Nature communications
Sundberg M,Pinson H,Smith RS,Winden KD,Venugopal P,Tai DJC,Gusella JF,Talkowski ME,Walsh CA,Tegmark M,Sahin M
Tue May 18 00:00:00 UTC 2021
Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis.
Cell death & disease
Gudiño V,Cammareri P,Billard CV,Myant KB
Sat Sep 25 00:00:00 UTC 2021
Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys.
Frontiers in pharmacology
Xu L,Tan B,Huang D,Yuan M,Li T,Wu M,Ye C
Tue Nov 07 00:00:00 UTC 2023
Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys.
Frontiers in pharmacology
Xu L,Tan B,Huang D,Yuan M,Li T,Wu M,Ye C
Tue Nov 07 00:00:00 UTC 2023
Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells' maturation and function.
Open life sciences
Guo B,Peng Y,Gu Y,Zhong Y,Su C,Liu L,Chai D,Song T,Zhao N,Yan X,Xu T
100-21 was used in In vitro experiments to indicate that resveratrol (RES) participated in protecting against the pathological process of ALI by modulating the maturation and function of cDCs.
Fri Aug 16 00:00:00 UTC 2024
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.
Cell death & disease
Egea V,Kessenbrock K,Lawson D,Bartelt A,Weber C,Ries C
Thu May 20 00:00:00 UTC 2021
EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas.
Neuropsychiatric disease and treatment
Chen K,Li G,Kang X,Liu P,Qian L,Shi Y,Osman RA,Yang Z,Zhang G
100-21 was used in Cell Culture to investigate pituitary adenomas invasiveness using non-invasive techniques and biomarkers.
Fri Apr 29 00:00:00 UTC 2022
GABARAP ameliorates IL-1β-induced inflammatory responses and osteogenic differentiation in bone marrow-derived stromal cells by activating autophagy.
Scientific reports
Guo X,Wu Z
Wed Jun 02 00:00:00 UTC 2021
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases.
Communications biology
Rada M,Kapelanski-Lamoureux A,Petrillo S,Tabariès S,Siegel P,Reynolds AR,Lazaris A,Metrakos P
Tue Aug 10 00:00:00 UTC 2021
Integrated computational and experimental pipeline for quantifying local cell-matrix interactions.
Scientific reports
Xiao H,Nguyen RY,LaRanger R,Herzog EL,Mak M
Thu Aug 12 00:00:00 UTC 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
100-21 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 UTC 2021
ILB® resolves inflammatory scarring and promotes functional tissue repair.
NPJ Regenerative medicine
Hill LJ,Botfield HF,Begum G,Qureshi O,Vigneswara V,Masood I,Barnes NM,Bruce L,Logan A
Thu Jan 07 00:00:00 UTC 2021
FZD2 promotes TGF-β-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway.
Cancer cell international
Tuluhong D,Chen T,Wang J,Zeng H,Li H,Dunzhu W,Li Q,Wang S
100-21 was used in In vitro experiments to investigate the role of FZD2 in advanced breast cancer and breast cancer progression.
Thu Apr 08 00:00:00 UTC 2021
The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation.
British journal of pharmacology
Pan Y,You Y,Sun L,Sui Q,Liu L,Yuan H,Chen C,Liu J,Wen X,Dai L,Sun H
100-21 was used in In vitro experiments to show that inhibition of STING signalling pathway may represent a novel therapeutic approach to psoriasis and related complications.
Wed Dec 01 00:00:00 UTC 2021
A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells.
Communications biology
Futrega K,Robey PG,Klein TJ,Crawford RW,Doran MR
Mon Jan 04 00:00:00 UTC 2021
The killing effect of Tanshinol on breast cancer cells: insight into the reversion of TGF-β1-mediated suppression of NK cell functions.
Frontiers in bioscience (Landmark edition)
Yang C,Qian C,Zhang T,Zheng W,Zhang S,Wang S,Wang A,Zhao Y,Lu Y
100-21 was used in In vitro experiments to conclude that Tanshinol enables NK cells to activate and release multiple killing mediators to carry out immune attacks on tumor cells.
Tue Nov 30 00:00:00 UTC 2021
The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching.
Cell reports
Bai W,Zhu G,Xu J,Chen P,Meng F,Xue H,Chen C,Dong J
Tue Sep 28 00:00:00 UTC 2021
The FibromiR miR-214-3p Is Upregulated in Duchenne Muscular Dystrophy and Promotes Differentiation of Human Fibro-Adipogenic Muscle Progenitors.
Cells
Arrighi N,Moratal C,Savary G,Fassy J,Nottet N,Pons N,Clément N,Fellah S,Larrue R,Magnone V,Lebrigand K,Pottier N,Dechesne C,Vassaux G,Dani C,Peraldi P,Mari B
100-21 was used in In vitro experiments to show that expression of the TGFβ1-induced miR-199a~214 cluster was strongly correlated with DMD and a miR-214-3p inhibitor efficiently blocked expression of fibrogenic markers in FAPs and thus acts as the key activator of FAP fibrogenesis.
Tue Jul 20 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Cell death & disease
Zhang W,Yin G,Zhao H,Ling H,Xie Z,Xiao C,Chen Y,Lin Y,Jiang T,Jin S,Wang J,Yang X
Wed Jan 20 00:00:00 UTC 2021
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Nature communications
Zehender A,Li YN,Lin NY,Stefanica A,Nüchel J,Chen CW,Hsu HH,Zhu H,Ding X,Huang J,Shen L,Györfi AH,Soare A,Rauber S,Bergmann C,Ramming A,Plomann M,Eckes B,Schett G,Distler JHW
Tue Jul 20 00:00:00 UTC 2021
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Nature communications
Zehender A,Li YN,Lin NY,Stefanica A,Nüchel J,Chen CW,Hsu HH,Zhu H,Ding X,Huang J,Shen L,Györfi AH,Soare A,Rauber S,Bergmann C,Ramming A,Plomann M,Eckes B,Schett G,Distler JHW
Tue Jul 20 00:00:00 UTC 2021
Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.
iScience
Chen X,Zhang Y,Qian W,Han L,Li W,Duan W,Wu Z,Wang Z,Ma Q
100-21 was used in Control to uncover that high Arl4c expression is associated with cell proliferation, drug resistance, and PSC activation, suggesting its vitality in pancreatic cancer progression.
Fri Dec 17 00:00:00 UTC 2021
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Scientific reports
Hasegawa H,Mizoguchi I,Orii N,Inoue S,Katahira Y,Yoneto T,Xu M,Miyazaki T,Yoshimoto T
Thu Mar 04 00:00:00 UTC 2021
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.
Communications biology
Herdenberg C,Mutie PM,Billing O,Abdullah A,Strawbridge RJ,Dahlman I,Tuck S,Holmlund C,Arner P,Henriksson R,Franks PW,Hedman H
Tue Jan 19 00:00:00 UTC 2021
A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models.
Scientific reports
Daou N,Viader A,Cokol M,Nitzel A,Chakravarthy MV,Afeyan R,Tramontin T,Marukian S,Hamill MJ
Fri Jun 04 00:00:00 UTC 2021
Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus.
Frontiers in immunology
Kato H,Perl A
100-21 was used in Cell Culture to study the effects of IL-2 on pro-inflammatory cytokine production by CD4+ and CD8+ T cells in parallel with Treg development following CD3/CD28 co-stimulation.
Tue Sep 21 00:00:00 UTC 2021
Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy.
Nature communications
Srivastava SP,Zhou H,Setia O,Liu B,Kanasaki K,Koya D,Dardik A,Fernandez-Hernando C,Goodwin J
Thu Apr 22 00:00:00 UTC 2021
The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions.
NPJ Regenerative medicine
Di Luca M,Fitzpatrick E,Burtenshaw D,Liu W,Helt JC,Hakimjavadi R,Corcoran E,Gusti Y,Sheridan D,Harman S,Lally C,Redmond EM,Cahill PA
Mon Mar 01 00:00:00 UTC 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 UTC 2021
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
100-21 was used in Enzyme-linked immunosorbent assay to present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins.
Thu Aug 06 00:00:00 UTC 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
100-21 was used in Enzyme-linked immunosorbent assay to present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins.
Thu Aug 06 00:00:00 UTC 2020
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
Thu Aug 06 00:00:00 UTC 2020
Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development.
Cell
Utz SG,See P,Mildenberger W,Thion MS,Silvin A,Lutz M,Ingelfinger F,Rayan NA,Lelios I,Buttgereit A,Asano K,Prabhakar S,Garel S,Becher B,Ginhoux F,Greter M
Thu Apr 30 00:00:00 UTC 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
Thu Jan 09 00:00:00 UTC 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
Thu Jan 09 00:00:00 UTC 2020
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
Cell
Wang J,Xu Y,Chen Z,Liang J,Lin Z,Liang H,Xu Y,Wu Q,Guo X,Nie J,Lu B,Huang B,Xian H,Wang X,Wu Q,Zeng J,Chai C,Zhang M,Lin Y,Zhang L,Zhao S,Tong Y,Zeng L,Gu X,Chen ZG,Yi S,Zhang T,Delfouneso D,Zhang Y,Nutt SL,Lew AM,Lu L,Bai F,Xia H,Wen Z,Zhang Y
Wed Dec 23 00:00:00 UTC 2020
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Immunity
Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B
Tue Sep 15 00:00:00 UTC 2020
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
Nature genetics
Kinker GS,Greenwald AC,Tal R,Orlova Z,Cuoco MS,McFarland JM,Warren A,Rodman C,Roth JA,Bender SA,Kumar B,Rocco JW,Fernandes PACM,Mader CC,Keren-Shaul H,Plotnikov A,Barr H,Tsherniak A,Rozenblatt-Rosen O,Krizhanovsky V,Puram SV,Regev A,Tirosh I
Sun Nov 01 00:00:00 UTC 2020
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Signal transduction and targeted therapy
Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q
Wed May 13 00:00:00 UTC 2020
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Cell metabolism
Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG
100-21 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.
Tue Feb 04 00:00:00 UTC 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 UTC 2020
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.
The Journal of clinical investigation
Faust HJ,Zhang H,Han J,Wolf MT,Jeon OH,Sadtler K,Peña AN,Chung L,Maestas DR,Tam AJ,Pardoll DM,Campisi J,Housseau F,Zhou D,Bingham CO,Elisseeff JH
Thu Oct 01 00:00:00 UTC 2020
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
The Journal of experimental medicine
Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C
Mon Apr 06 00:00:00 UTC 2020
Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
The Journal of experimental medicine
Liu T,Zhu B,Liu Y,Zhang X,Yin J,Li X,Jiang L,Hodges AP,Rosenthal SB,Zhou L,Yancey J,McQuade A,Blurton-Jones M,Tanzi RE,Huang TY,Xu H
Mon Dec 07 00:00:00 UTC 2020
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
EMBO molecular medicine
Kahlfuss S,Kaufmann U,Concepcion AR,Noyer L,Raphael D,Vaeth M,Yang J,Pancholi P,Maus M,Muller J,Kozhaya L,Khodadadi-Jamayran A,Sun Z,Shaw P,Unutmaz D,Stathopulos PB,Feist C,Cameron SB,Turvey SE,Feske S
Fri Aug 07 00:00:00 UTC 2020
A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming.
EMBO molecular medicine
Cangkrama M,Wietecha M,Mathis N,Okumura R,Ferrarese L,Al-Nuaimi D,Antsiferova M,Dummer R,Innocenti M,Werner S
Tue Apr 07 00:00:00 UTC 2020
Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.
The EMBO journal
Feldker N,Ferrazzi F,Schuhwerk H,Widholz SA,Guenther K,Frisch I,Jakob K,Kleemann J,Riegel D,Bönisch U,Lukassen S,Eccles RL,Schmidl C,Stemmler MP,Brabletz T,Brabletz S
Tue Sep 01 00:00:00 UTC 2020
PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kwon M,Kim CG,Lee H,Cho H,Kim Y,Lee EC,Choi SJ,Park J,Seo IH,Bogen B,Song IC,Jo DY,Kim JS,Park SH,Choi I,Choi YS,Shin EC
100-21 was used in Cell Culture to indicate that combined blockade of PD-1 and TGFβ may be useful for the treatment of multiple myeloma.
Wed Apr 01 00:00:00 UTC 2020
Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling.
Cancer research
Georgess D,Padmanaban V,Sirka OK,Coutinho K,Choi A,Frid G,Neumann NM,Inoue T,Ewald AJ
100-21 was used in Cell Culture to investigate the mechanisms involved Twist1-induced epithelial dissemination.
Wed Jan 15 00:00:00 UTC 2020
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Proceedings of the National Academy of Sciences of the United States of America
Cribbs AP,Terlecki-Zaniewicz S,Philpott M,Baardman J,Ahern D,Lindow M,Obad S,Oerum H,Sampey B,Mander PK,Penn H,Wordsworth P,Bowness P,de Winther M,Prinjha RK,Feldmann M,Oppermann U
Tue Mar 17 00:00:00 UTC 2020
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
Aging cell
Shang D,Sun D,Shi C,Xu J,Shen M,Hu X,Liu H,Tu Z
Fri May 01 00:00:00 UTC 2020
Major histocompatibility complexes are up-regulated in glomerular endothelial cells via activation of c-Jun N-terminal kinase in 5/6 nephrectomy mice.
British journal of pharmacology
Zhu D,Tang Q,Yu B,Meng M,Liu W,Li J,Zhu T,Vanhoutte PM,Leung SWS,Zhang Y,Shi Y
Sun Nov 01 00:00:00 UTC 2020
Regulation of ICa,L and force by PDEs in human-induced pluripotent stem cell-derived cardiomyocytes.
British journal of pharmacology
Saleem U,Ismaili D,Mannhardt I,Pinnschmidt H,Schulze T,Christ T,Eschenhagen T,Hansen A
Wed Jul 01 00:00:00 UTC 2020
Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.
Clinical and translational medicine
Huang X,He C,Hua X,Kan A,Mao Y,Sun S,Duan F,Wang J,Huang P,Li S
Mon Jun 01 00:00:00 UTC 2020
SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis.
Glia
Malik AR,Lips J,Gorniak-Walas M,Broekaart DWM,Asaro A,Kuffner MTC,Hoffmann CJ,Kikhia M,Dopatka M,Boehm-Sturm P,Mueller S,Dirnagl U,Aronica E,Harms C,Willnow TE
Mon Jun 01 00:00:00 UTC 2020
GARP is a key molecule for mesenchymal stromal cell responses to TGF-β and fundamental to control mitochondrial ROS levels.
Stem cells translational medicine
Carrillo-Gálvez AB,Gálvez-Peisl S,González-Correa JE,de Haro-Carrillo M,Ayllón V,Carmona-Sáez P,Ramos-Mejía V,Galindo-Moreno P,Cara FE,Granados-Principal S,Muñoz P,Martin F,Anderson P
Fri May 01 00:00:00 UTC 2020
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.
Molecular oncology
Navarro R,Tapia-Galisteo A,Martín-García L,Tarín C,Corbacho C,Gómez-López G,Sánchez-Tirado E,Campuzano S,González-Cortés A,Yáñez-Sedeño P,Compte M,Álvarez-Vallina L,Sanz L
Thu Oct 01 00:00:00 UTC 2020
Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma.
Molecular oncology
Steins A,Klaassen R,Jacobs I,Schabel MC,van Lier MGJTB,Ebbing EA,Hectors SJ,Tas SW,Maracle CX,Punt CJA,Siebes M,Bergman JJGHM,Medema JP,Wilmink JW,Mathot RAA,Strijkers GJ,Bijlsma MF,van Laarhoven HWM
Wed Apr 01 00:00:00 UTC 2020
Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation.
Frontiers in cell and developmental biology
Wu X,Dong W,Zhang T,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X,Xu Y
100-21 was used in Cell Culture to study the transcription regulation of epiregulin (EREG), an EGFR ligand, during hepatic stellate cell (HSC) activation.
Tue Feb 02 00:00:00 UTC 2021
Endochondral Bone Regeneration by Non-autologous Mesenchymal Stem Cells.
Frontiers in bioengineering and biotechnology
Longoni A,Pennings I,Cuenca Lopera M,van Rijen MHP,Peperzak V,Rosenberg AJWP,Levato R,Gawlitta D
100-21 was used in Cell Culture to investigate the cause of MSCs triggering undesired immune response during bone regeneration.
Mon Sep 28 00:00:00 UTC 2020
Attenuated pulmonary fibrosis in sialidase-3 knockout () mice.
American journal of physiology. Lung cellular and molecular physiology
Karhadkar TR,Chen W,Gomer RH
Wed Jan 01 00:00:00 UTC 2020
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu Q,Dong H,Bukhari AA,Zhao A,Li M,Sun Y,Zhang X,Cao C,Su D,Liang X
Sun Mar 01 00:00:00 UTC 2020
The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gerner MC,Ziegler LS,Schmidt RLJ,Krenn M,Zimprich F,Uyanik-Ünal K,Konstantopoulou V,Derdak S,Del Favero G,Schwarzinger I,Boztug K,Schmetterer KG
Mon Jun 01 00:00:00 UTC 2020
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D
Mon Jun 01 00:00:00 UTC 2020
Pembrolizumab Interferes with the Differentiation of Human FOXP3+-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR.
Journal of immunology (Baltimore, Md. : 1950)
Sasidharan Nair V,Toor SM,Taouk G,Pfister G,Ouararhni K,Alajez NM,Elkord E
Wed Jan 01 00:00:00 UTC 2020
GPA33: A Marker to Identify Stable Human Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Opstelten R,de Kivit S,Slot MC,van den Biggelaar M,Iwaszkiewicz-Grześ D,Gliwiński M,Scott AM,Blom B,Trzonkowski P,Borst J,Cuadrado E,Amsen D
Mon Jun 15 00:00:00 UTC 2020
miR-145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy.
Journal of cellular and molecular medicine
Wang W,Chen L,Shang C,Jin Z,Yao F,Bai L,Wang R,Zhao S,Liu E
Mon Jun 01 00:00:00 UTC 2020
Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved in the pathogenesis of intrauterine adhesion.
Journal of cellular and molecular medicine
Chen G,Liu L,Sun J,Zeng L,Cai H,He Y
Sun Mar 01 00:00:00 UTC 2020
Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
Journal of cellular and molecular medicine
Qian W,Cai X,Qian Q,Zhang W,Tian L
Mon Jun 01 00:00:00 UTC 2020
MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88.
Journal of cellular and molecular medicine
Xu T,Pan L,Li L,Hu S,Zhou H,Yang C,Yang J,Li H,Liu Y,Meng X,Li J
Wed Jul 01 00:00:00 UTC 2020
Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway.
Journal of cellular and molecular medicine
Yang JJ,Yang Y,Zhang C,Li J,Yang Y
Sat Feb 01 00:00:00 UTC 2020
Endothelial S1pr1 regulates pressure overload-induced cardiac remodelling through AKT-eNOS pathway.
Journal of cellular and molecular medicine
Liu X,Wu J,Zhu C,Liu J,Chen X,Zhuang T,Kuang Y,Wang Y,Hu H,Yu P,Fan H,Zhang Y,Liu Z,Zhang L
Wed Jan 01 00:00:00 UTC 2020
Stromal cells cultivated from the choroid of human eyes display a mesenchymal stromal cell (MSC) phenotype and inhibit the proliferation of choroidal vascular endothelial cells in vitro.
Experimental eye research
Alexander N,Walshe J,Richardson NA,Futrega K,Doran MR,Harkin DG,Shadforth AMA
100-21 was used in Cell Culture to evaluate the use of choroidal stromal cells to generate choroidal vascular endothelial cells.
Sun Nov 01 00:00:00 UTC 2020
TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions.
Molecular biology of the cell
Aki S,Yoshioka K,Takuwa N,Takuwa Y
100-21 was used in In vitro experiments to investigate which enzymes are involved in phosphoinositide conversions for receptor endocytosis.
Sun Mar 01 00:00:00 UTC 2020
Involvement of the TGF-β1 pathway in caveolin-1-associated regulation of head and neck tumor cell metastasis.
Oncology letters
Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X
100-21 was used in Cell Culture to indicate that Cav-1 inhibits cell metastasis in HNSCC, suggesting the involvement of the TGF-β signaling pathway.
Sat Feb 01 00:00:00 UTC 2020
TGF β-1 and WNT Signaling Pathways Collaboration Associated with Cochlear Implantation Trauma-Induced Fibrosis.
Anatomical record (Hoboken, N.J. : 2007)
Bas E,Anwar MR,Van De Water TR
100-21 was used in Tissue/organ culture to show that in light of our observations from the current study, manipulation of the WNT pathway by gene therapy techniques in the pathological ear seems a very complex process with an increased risk of inducing excessive fibrosis thereby compromising the efficacy of implant function.
Sun Mar 01 00:00:00 UTC 2020
Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix.
eLife
Zamboulis DE,Thorpe CT,Ashraf Kharaz Y,Birch HL,Screen HR,Clegg PD
100-21 was used in Sample Preparation (PCR) to explore functional adaptation and specialisation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which the collagen (fascicle) and surrounding predominantly non-collagenous matrix (interfascicular matrix) can be interrogated independently.
Fri Oct 16 00:00:00 UTC 2020
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.
Oncoimmunology
Stokes J,Hoffman EA,Molina MS,Kummet N,Simpson RJ,Zeng Y,Katsanis E
100-21 was used in Cell Culture to demonstrate that BEN-TBI reduces graft-versus-host disease (GvHD) compared to CY-TBI independently of T regulatory cells (Tregs).
Wed Jul 14 00:00:00 UTC 2021
The long noncoding RNA TUG1 is required for TGF-β/TWIST1/EMT-mediated metastasis in colorectal cancer cells.
Cell death & disease
Shen X,Hu X,Mao J,Wu Y,Liu H,Shen J,Yu J,Chen W
Mon Jan 27 00:00:00 UTC 2020
Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage.
Scientific reports
Takei Y,Morioka M,Yamashita A,Kobayashi T,Shima N,Tsumaki N
Thu Jul 30 00:00:00 UTC 2020
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
eLife
Alonso-Herranz L,Sahún-Español Á,Paredes A,Gonzalo P,Gkontra P,Núñez V,Clemente C,Cedenilla M,Villalba-Orero M,Inserte J,García-Dorado D,Arroyo AG,Ricote M
100-21 was used in In vitro experiments to indicate the contribution of EndMT to cardiac fibrosis and adverse remodeling post-MI and identify Mφ MT1-MMP as a key regulator of this process.
Fri Oct 16 00:00:00 UTC 2020
Transforming growth factor-beta stimulates human bone marrow-derived mesenchymal stem/stromal cell chondrogenesis more so than kartogenin.
Scientific reports
Music E,Klein TJ,Lott WB,Doran MR
Wed May 20 00:00:00 UTC 2020
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.
The Journal of biological chemistry
Shi Y,Wang X,Xu Z,He Y,Guo C,He L,Huan C,Cai C,Huang J,Zhang J,Li Y,Zeng C,Zhang X,Wang L,Ke Y,Cheng H
Fri Oct 02 00:00:00 UTC 2020
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Cell death & disease
Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC
Mon Mar 02 00:00:00 UTC 2020
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection.
Stem cell reports
Ryan SK,Gonzalez MV,Garifallou JP,Bennett FC,Williams KS,Sotuyo NP,Mironets E,Cook K,Hakonarson H,Anderson SA,Jordan-Sciutto KL
Tue Apr 14 00:00:00 UTC 2020
Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nilsson Hall G,Mendes LF,Gklava C,Geris L,Luyten FP,Papantoniou I
Wed Jan 01 00:00:00 UTC 2020
The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs.
Nature communications
Zorzan I,Pellegrini M,Arboit M,Incarnato D,Maldotti M,Forcato M,Tagliazucchi GM,Carbognin E,Montagner M,Oliviero S,Martello G
Tue May 12 00:00:00 UTC 2020
Quantitative proteomics reveal lineage-specific protein profiles in iPSC-derived Marfan syndrome smooth muscle cells.
Scientific reports
Iosef C,Pedroza AJ,Cui JZ,Dalal AR,Arakawa M,Tashima Y,Koyano TK,Burdon G,Churovich SMP,Orrick JO,Pariani M,Fischbein MP
Mon Nov 23 00:00:00 UTC 2020
An electrochemical biosensor for the detection of epithelial-mesenchymal transition.
Nature communications
Du X,Zhang Z,Zheng X,Zhang H,Dong D,Zhang Z,Liu M,Zhou J
Fri Jan 10 00:00:00 UTC 2020
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.
Nature communications
Zafeiriou MP,Bao G,Hudson J,Halder R,Blenkle A,Schreiber MK,Fischer A,Schild D,Zimmermann WH
Wed Jul 29 00:00:00 UTC 2020
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Molecular systems biology
Morshed N,Ralvenius WT,Nott A,Watson LA,Rodriguez FH,Akay LA,Joughin BA,Pao PC,Penney J,LaRocque L,Mastroeni D,Tsai LH,White FM
Tue Dec 01 00:00:00 UTC 2020
CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response.
Cell reports
Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD
100-21 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.
Tue Sep 01 00:00:00 UTC 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
Tue Jan 14 00:00:00 UTC 2020
MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.
Cell death & disease
Tang H,Wang X,Zhang M,Yan Y,Huang S,Ji J,Xu J,Zhang Y,Cai Y,Yang B,Lan W,Huang M,Zhang L
Thu Oct 29 00:00:00 UTC 2020
Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells.
Cell reports
Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P
100-21 was used in In vitro experiments to establish that BMPs, a large cytokine family, are an essential link between stromal tissues and the adaptive immune system involved in sustaining tissue homeostasis by promoting immunological tolerance.
Tue Oct 06 00:00:00 UTC 2020
Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-β and paclitaxel in A549 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Bacon NA,Larre I,Lawag AA,Merritt C,Smith M,Rosolen M,Sollars VE
100-21 was used in In vitro experiments to indicate that HSP90 inhibition with AUY922 can limit the acquisition of metastatic and drug resistant phenotypes in A549 cells at low, clinically appropriate doses.
Tue Sep 01 00:00:00 UTC 2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Scientific reports
Cai S,Choi JY,Borges TJ,Zhang H,Miao J,Ichimura T,Li X,Xu S,Chu P,Eskandari SK,Allos H,Alhaddad JB,Muhsin SA,Yatim K,Riella LV,Sage PT,Chandraker AK,Azzi JR
Fri Aug 28 00:00:00 UTC 2020
PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation.
Scientific reports
Shimizu T,Maruyama K,Kawamura T,Urade Y,Wada Y
Wed Nov 18 00:00:00 UTC 2020
Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
EBioMedicine
Lu HH,Lin SY,Weng RR,Juan YH,Chen YW,Hou HH,Hung ZC,Oswita GA,Huang YJ,Guu SY,Khoo KH,Shih JY,Yu CJ,Tsai HC
100-21 was used in Cell Culture to study the molecular mechanisms of the key fucosyltransferase with prognostic significance in lung cancer patients and the enzyme's intracellular targets to demonstrate that FUT4 can be a prognostic predictor and therapeutic target in lung cancer metastasis.
Wed Jul 01 00:00:00 UTC 2020
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer.
The Journal of biological chemistry
Takahashi K,Akatsu Y,Podyma-Inoue KA,Matsumoto T,Takahashi H,Yoshimatsu Y,Koinuma D,Shirouzu M,Miyazono K,Watabe T
Fri Sep 04 00:00:00 UTC 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
100-21 was used in Cell Culture to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 UTC 2020
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Nature communications
Lee TH,Yeh CF,Lee YT,Shih YC,Chen YT,Hung CT,You MY,Wu PC,Shentu TP,Huang RT,Lin YS,Wu YF,Lin SJ,Lu FL,Tsao PN,Lin TH,Lo SC,Tseng YS,Wu WL,Chen CN,Wu CC,Lin SL,Sperling AI,Guzy RD,Fang Y,Yang KC
Wed Aug 26 00:00:00 UTC 2020
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Nature communications
Lee TH,Yeh CF,Lee YT,Shih YC,Chen YT,Hung CT,You MY,Wu PC,Shentu TP,Huang RT,Lin YS,Wu YF,Lin SJ,Lu FL,Tsao PN,Lin TH,Lo SC,Tseng YS,Wu WL,Chen CN,Wu CC,Lin SL,Sperling AI,Guzy RD,Fang Y,Yang KC
Wed Aug 26 00:00:00 UTC 2020
Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.
STAR protocols
Ryan SK,Jordan-Sciutto KL,Anderson SA
Fri Dec 18 00:00:00 UTC 2020
Interference of miR-107 with Atg12 is inhibited by HULC to promote metastasis of hepatocellular carcinoma.
MedComm
Zhang H,Li S,Xu H,Sun L,Zhu Z,Yao Z
Tue Sep 01 00:00:00 UTC 2020
Tissue-scale tensional homeostasis in skin regulates structure and physiological function.
Communications biology
Kimura S,Tsuchiya A,Ogawa M,Ono M,Suda N,Sekimoto K,Takeo M,Tsuji T
Fri Oct 30 00:00:00 UTC 2020
Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.
Stem cell research & therapy
Shi Z,Wang Q,Zhang Y,Jiang D
100-21 was used in In vitro experiments to show that BMSC-EVs containing MFG-E8 attenuate renal fibrosis in a rat model of renal fibrosis, partly through RhoA/ROCK pathway inhibition.
Fri Jun 26 00:00:00 UTC 2020
Irradiated Tumor Fibroblasts Avoid Immune Recognition and Retain Immunosuppressive Functions Over Natural Killer Cells.
Frontiers in immunology
Yang N,Lode K,Berzaghi R,Islam A,Martinez-Zubiaurre I,Hellevik T
100-21 was used in In vitro experiments to study whether ionizing radiation alters cancer-associated fibroblast (CAF)-mediated immunoregulatory effects on natural killer (NK) cells.
Thu Jun 17 00:00:00 UTC 2021
Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
The Journal of biological chemistry
Lear TB,Lockwood KC,Larsen M,Tuncer F,Kennerdell JR,Morse C,Valenzi E,Tabib T,Jurczak MJ,Kass DJ,Evankovich JW,Finkel T,Lafyatis R,Liu Y,Chen BB
Fri Mar 27 00:00:00 UTC 2020
Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.
Scientific reports
Wang J,Roberts S,Kuiper JH,Zhang W,Garcia J,Cui Z,Wright K
Thu Dec 10 00:00:00 UTC 2020
CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model.
Frontiers in immunology
Wang N,Yi H,Fang L,Jin J,Ma Q,Shen Y,Li J,Liang S,Xiong J,Li Z,Zeng H,Jiang F,Jin B,Chen L
100-21 was used in Cell Culture to investigate the importance of CD226 in immune cell activation, utilizing mouse models.
Mon Apr 19 00:00:00 UTC 2021
β-arrestin2 deficiency protects against hepatic fibrosis in mice and prevents synthesis of extracellular matrix.
Cell death & disease
Sun WY,Gu YJ,Li XR,Sun JC,Du JJ,Chen JY,Ma Y,Wang QT,Wei W
Thu May 21 00:00:00 UTC 2020
Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly.
Scientific reports
Parfenov VA,Mironov VA,Koudan EV,Nezhurina EK,Karalkin PA,Pereira FD,Petrov SV,Krokhmal AA,Aydemir T,Vakhrushev IV,Zobkov YV,Smirnov IV,Fedotov AY,Demirci U,Khesuani YD,Komlev VS
Wed Mar 04 00:00:00 UTC 2020
Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts.
Scientific reports
El-Hattab MY,Nagumo Y,Gourronc FA,Klingelhutz AJ,Ankrum JA,Sander EA
100-21 was used in In vitro experiments to investigate interactions between adipocytes and precursors with surrounding cell types in wound healing via secreted factors in vitro.
Wed Jun 24 00:00:00 UTC 2020
The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
The Journal of biological chemistry
Kiepas A,Voorand E,Senecal J,Ahn R,Annis MG,Jacquet K,Tali G,Bisson N,Ursini-Siegel J,Siegel PM,Brown CM
Fri Jul 31 00:00:00 UTC 2020
Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition.
Cell death & disease
Quaresma MC,Pankonien I,Clarke LA,Sousa LS,Silva IAL,Railean V,Doušová T,Fuxe J,Amaral MD
Mon Oct 26 00:00:00 UTC 2020
Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming.
Nature communications
Krawczyk K,Scheller L,Kim H,Fussenegger M
Thu Jan 30 00:00:00 UTC 2020
Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis.
Stem cell research & therapy
Lee M,Kim SH,Jhee JH,Kim TY,Choi HY,Kim HJ,Park HC
100-21 was used in In vitro experiments to demonstrate that hEPO-MPs modulate TGF-β1-induced EMT in MDCK cells via the Smad2, Smad3, and p38 MAPK pathways and significantly attenuated renal TIF in UUO kidneys.
Tue Sep 29 00:00:00 UTC 2020
Microparticles derived from human erythropoietin mRNA-transfected mesenchymal stem cells inhibit epithelial-to-mesenchymal transition and ameliorate renal interstitial fibrosis.
Stem cell research & therapy
Lee M,Kim SH,Jhee JH,Kim TY,Choi HY,Kim HJ,Park HC
100-21 was used in In vitro experiments to demonstrate that hEPO-MPs modulate TGF-β1-induced EMT in MDCK cells via the Smad2, Smad3, and p38 MAPK pathways and significantly attenuated renal TIF in UUO kidneys.
Tue Sep 29 00:00:00 UTC 2020
A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.
Cell
Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V
Thu Oct 03 00:00:00 UTC 2019
A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.
Cell
Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V
Thu Oct 03 00:00:00 UTC 2019
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Cell
Huang B,Chen Z,Geng L,Wang J,Liang H,Cao Y,Chen H,Huang W,Su M,Wang H,Xu Y,Liu Y,Lu B,Xian H,Li H,Li H,Ren L,Xie J,Ye L,Wang H,Zhao J,Chen P,Zhang L,Zhao S,Zhang T,Xu B,Che D,Si W,Gu X,Zeng L,Wang Y,Li D,Zhan Y,Delfouneso D,Lew AM,Cui J,Tang WH,Zhang Y,Gong S,Bai F,Yang M,Zhang Y
Thu Nov 14 00:00:00 UTC 2019
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Cell
Garcia-Campos MA,Edelheit S,Toth U,Safra M,Shachar R,Viukov S,Winkler R,Nir R,Lasman L,Brandis A,Hanna JH,Rossmanith W,Schwartz S
Thu Jul 25 00:00:00 UTC 2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
Thu Jan 24 00:00:00 UTC 2019
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
Immunity
Schmidleithner L,Thabet Y,Schönfeld E,Köhne M,Sommer D,Abdullah Z,Sadlon T,Osei-Sarpong C,Subbaramaiah K,Copperi F,Haendler K,Varga T,Schanz O,Bourry S,Bassler K,Krebs W,Peters AE,Baumgart AK,Schneeweiss M,Klee K,Schmidt SV,Nüssing S,Sander J,Ohkura N,Waha A,Sparwasser T,Wunderlich FT,Förster I,Ulas T,Weighardt H,Sakaguchi S,Pfeifer A,Blüher M,Dannenberg AJ,Ferreirós N,Muglia LJ,Wickenhauser C,Barry SC,Schultze JL,Beyer M
Tue May 21 00:00:00 UTC 2019
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity
Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA
Tue Sep 17 00:00:00 UTC 2019
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity
Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA
Tue Sep 17 00:00:00 UTC 2019
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell
Gomes AP,Ilter D,Low V,Rosenzweig A,Shen ZJ,Schild T,Rivas MA,Er EE,McNally DR,Mutvei AP,Han J,Ou YH,Cavaliere P,Mullarky E,Nagiec M,Shin S,Yoon SO,Dephoure N,Massagué J,Melnick AM,Cantley LC,Tyler JK,Blenis J
Mon Oct 14 00:00:00 UTC 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
100-21 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 UTC 2019
CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion.
The Journal of clinical investigation
Park J,Zhang X,Lee SK,Song NY,Son SH,Kim KR,Shim JH,Park KK,Chung WY
Mon Dec 02 00:00:00 UTC 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 UTC 2019
Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation.
The Journal of clinical investigation
Papaioannou E,Yánez DC,Ross S,Lau CI,Solanki A,Chawda MM,Virasami A,Ranz I,Ono M,O'Shaughnessy RFL,Crompton T
Tue Jul 02 00:00:00 UTC 2019
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.
Molecular cell
Modic M,Grosch M,Rot G,Schirge S,Lepko T,Yamazaki T,Lee FCY,Rusha E,Shaposhnikov D,Palo M,Merl-Pham J,Cacchiarelli D,Rogelj B,Hauck SM,von Mering C,Meissner A,Lickert H,Hirose T,Ule J,Drukker M
100-21 was used in Cell Culture to study the joint role of RNA binding proteins and long non-coding RNAs in coordinating cell fate decisions.
Thu Jun 06 00:00:00 UTC 2019
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Neuron
Hasselmann J,Coburn MA,England W,Figueroa Velez DX,Kiani Shabestari S,Tu CH,McQuade A,Kolahdouzan M,Echeverria K,Claes C,Nakayama T,Azevedo R,Coufal NG,Han CZ,Cummings BJ,Davtyan H,Glass CK,Healy LM,Gandhi SP,Spitale RC,Blurton-Jones M
Wed Sep 25 00:00:00 UTC 2019
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.
The Journal of experimental medicine
Rana BMJ,Jou E,Barlow JL,Rodriguez-Rodriguez N,Walker JA,Knox C,Jolin HE,Hardman CS,Sivasubramaniam M,Szeto A,Cohen ES,Scott IC,Sleeman MA,Chidomere CI,Cruz Migoni S,Caamano J,Jorgensen HF,Carobbio S,Vidal-Puig A,McKenzie ANJ
Mon Sep 02 00:00:00 UTC 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
The Journal of experimental medicine
Sun X,Cui Y,Feng H,Liu H,Liu X
Mon Dec 02 00:00:00 UTC 2019
Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
The Journal of experimental medicine
Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S
Mon Jun 03 00:00:00 UTC 2019
Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses.
The Journal of experimental medicine
Durand M,Walter T,Pirnay T,Naessens T,Gueguen P,Goudot C,Lameiras S,Chang Q,Talaei N,Ornatsky O,Vassilevskaia T,Baulande S,Amigorena S,Segura E
Mon Jul 01 00:00:00 UTC 2019
A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.
EMBO molecular medicine
Lin CL,Hsu YC,Huang YT,Shih YH,Wang CJ,Chiang WC,Chang PJ
Wed May 01 00:00:00 UTC 2019
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.
Cell death and differentiation
Battistelli C,Sabarese G,Santangelo L,Montaldo C,Gonzalez FJ,Tripodi M,Cicchini C
Wed May 01 00:00:00 UTC 2019
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.
Aging cell
Martini H,Iacovoni JS,Maggiorani D,Dutaur M,Marsal DJ,Roncalli J,Itier R,Dambrin C,Pizzinat N,Mialet-Perez J,Cussac D,Parini A,Lefevre L,Douin-Echinard V
Tue Oct 01 00:00:00 UTC 2019
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.
Aging cell
Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ
Thu Aug 01 00:00:00 UTC 2019
Perlecan domain I gradients establish stable biomimetic heparin binding growth factor gradients for cell migration in hydrogels.
Acta biomaterialia
Hubka KM,Carson DD,Harrington DA,Farach-Carson MC
100-21 was used in Cell Culture to demonstrate the ability of a variety of cells, including primary salivary stem/progenitor cells, pre-osteoblastic cells and an invasive breast cancer cell line, to be co-encapsulated in gradient hydrogels by flowing them together through the MGMD.
Tue Oct 01 00:00:00 UTC 2019
VISTA expressed in tumour cells regulates T cell function.
British journal of cancer
Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M
Tue Jan 01 00:00:00 UTC 2019
JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling.
Mucosal immunology
Katagiri T,Yamazaki S,Fukui Y,Aoki K,Yagita H,Nishina T,Mikami T,Katagiri S,Shiraishi A,Kimura S,Tateda K,Sumimoto H,Endo S,Kameda H,Nakano H
Sun Sep 01 00:00:00 UTC 2019
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.
Mucosal immunology
Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J
Sun Sep 01 00:00:00 UTC 2019
Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
Glia
Baror R,Neumann B,Segel M,Chalut KJ,Fancy SPJ,Schafer DP,Franklin RJM
Mon Jul 01 00:00:00 UTC 2019
Integrin α5 subunit is required for the tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic marker.
Molecular oncology
Lu L,Xie R,Wei R,Cai C,Bi D,Yin D,Liu H,Zheng J,Zhang Y,Song F,Gao Y,Tan L,Wei Q,Qin H
Sun Dec 01 00:00:00 UTC 2019
Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.
International journal of cancer
Steins A,Ebbing EA,Creemers A,van der Zalm AP,Jibodh RA,Waasdorp C,Meijer SL,van Delden OM,Krishnadath KK,Hulshof MCCM,Bennink RJ,Punt CJA,Medema JP,Bijlsma MF,van Laarhoven HWM
Fri Nov 15 00:00:00 UTC 2019
LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.
Oncogenesis
Morén A,Bellomo C,Tsubakihara Y,Kardassis D,Mikulits W,Heldin CH,Moustakas A
Thu May 16 00:00:00 UTC 2019
Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition.
Journal of cellular physiology
de Jong OG,van der Waals LM,Kools FRW,Verhaar MC,van Balkom BWM
Mon Jul 01 00:00:00 UTC 2019
Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling.
American journal of physiology. Lung cellular and molecular physiology
Mukherjee S,Sheng W,Michkov A,Sriarm K,Sun R,Dvorkin-Gheva A,Insel PA,Janssen LJ
Wed May 01 00:00:00 UTC 2019
Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liu YG,Teng YS,Cheng P,Kong H,Lv YP,Mao FY,Wu XL,Hao CJ,Chen W,Yang SM,Zhang JY,Peng LS,Wang TT,Han B,Ma Q,Zou QM,Zhuang Y
100-21 was used in In vitro experiments to investigate the role of Cathepsin C expression on the gastric epithelial cell of Helicobacter pylori infection.
Mon Apr 01 00:00:00 UTC 2019
FAM3C-YY1 axis is essential for TGFβ-promoted proliferation and migration of human breast cancer MDA-MB-231 cells via the activation of HSF1.
Journal of cellular and molecular medicine
Yang W,Feng B,Meng Y,Wang J,Geng B,Cui Q,Zhang H,Yang Y,Yang J
Wed May 01 00:00:00 UTC 2019
The Akt/FoxO/p27Kip1 axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars.
Journal of cellular and molecular medicine
Yang F,Chen E,Yang Y,Han F,Han S,Wu G,Zhang M,Zhang J,Han J,Su L,Hu D
Sun Sep 01 00:00:00 UTC 2019
Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis.
Journal of cellular and molecular medicine
Feng J,Wang C,Liu T,Li J,Wu L,Yu Q,Li S,Zhou Y,Zhang J,Chen J,Ji J,Chen K,Mao Y,Wang F,Dai W,Fan X,Wu J,Guo C
Sun Sep 01 00:00:00 UTC 2019
Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.
Journal of cellular and molecular medicine
Liu G,Wang Y,Yang L,Zou B,Gao S,Song Z,Lin Z
Wed May 01 00:00:00 UTC 2019
Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.
Journal of cellular and molecular medicine
Liu G,Wang Y,Yang L,Zou B,Gao S,Song Z,Lin Z
Wed May 01 00:00:00 UTC 2019
Deletion of transcription factor AP-2α gene attenuates fibroblast differentiation into myofibroblast.
Journal of cellular and molecular medicine
Ross GR,Edwards S,Warner C,Homar P,Downey FX,Emelyanova L,Rizvi F,Jahangir A
Sun Sep 01 00:00:00 UTC 2019
Knockdown of CD44 expression decreases valve interstitial cell calcification in vitro.
American journal of physiology. Heart and circulatory physiology
Baugh L,Watson MC,Kemmerling EC,Hinds PW,Huggins GS,Black LD
100-21 was used in Cell Culture to study how the relationship between valve interstitial cells (VICs) and the extracellular matrix (ECM) may lead to a better understand of calcific aortic valve disease (CAVD) mechanisms and potential pharmaceutical targets.
Mon Jul 01 00:00:00 UTC 2019
A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition.
American journal of physiology. Renal physiology
Ó hAinmhire E,Wu H,Muto Y,Donnelly EL,Machado FG,Fan LX,Chang-Panesso M,Humphreys BD
100-21 was used in In vitro experiments to develop a strategy to isolate kidney-Gli1 cells and observe their differentiation to myofibroblasts.
Tue Jan 01 00:00:00 UTC 2019
CCN5 Reduces Ligamentum Flavum Hypertrophy by Modulating the TGF-β Pathway.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Ye S,Kwon WK,Bae T,Kim S,Lee JB,Cho TH,Park JY,Kim K,Hur JK,Hur JW
Sun Dec 01 00:00:00 UTC 2019
Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis.
Nature communications
Shen WC,Lai YC,Li LH,Liao K,Lai HC,Kao SY,Wang J,Chuong CM,Hung SC
Mon May 20 00:00:00 UTC 2019
EMT is associated with an epigenetic signature of ECM remodeling genes.
Cell death & disease
Peixoto P,Etcheverry A,Aubry M,Missey A,Lachat C,Perrard J,Hendrick E,Delage-Mourroux R,Mosser J,Borg C,Feugeas JP,Herfs M,Boyer-Guittaut M,Hervouet E
Wed Feb 27 00:00:00 UTC 2019
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
The Journal of biological chemistry
Kolliopoulos C,Raja E,Razmara M,Heldin P,Heldin CH,Moustakas A,van der Heide LP
Fri Mar 15 00:00:00 UTC 2019
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
The Journal of biological chemistry
Kolliopoulos C,Raja E,Razmara M,Heldin P,Heldin CH,Moustakas A,van der Heide LP
Fri Mar 15 00:00:00 UTC 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
100-21 was used in In vitro experiments to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 UTC 2019
Transcriptional Circuit Fragility Influences HIV Proviral Fate.
Cell reports
Morton EL,Forst CV,Zheng Y,DePaula-Silva AB,Ramirez NP,Planelles V,D'Orso I
100-21 was used in In vitro experiments to study the effect of transcriptional fragility on HIV viral fate and cure efforts.
Tue Apr 02 00:00:00 UTC 2019
Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis.
Cell death & disease
Liu D,Wang K,Li K,Xu R,Chang X,Zhu Y,Sun P,Han X
Wed Jun 12 00:00:00 UTC 2019
Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting.
Cell reports
Langer EM,Allen-Petersen BL,King SM,Kendsersky ND,Turnidge MA,Kuziel GM,Riggers R,Samatham R,Amery TS,Jacques SL,Sheppard BC,Korkola JE,Muschler JL,Thibault G,Chang YH,Gray JW,Presnell SC,Nguyen DG,Sears RC
100-21 was used in In vitro experiments to demonstrate that multi-cell-type bioprinted tissues can recapitulate aspects of in vivo neoplastic tissues and provide a manipulable system for the interrogation of multiple tumorigenic endpoints in the context of distinct tumor microenvironments.
Tue Jan 15 00:00:00 UTC 2019
ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.
Cell death & disease
Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A
Mon Oct 07 00:00:00 UTC 2019
Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage.
Scientific reports
Sasaki N,Hirabayashi K,Michishita M,Takahashi K,Hasegawa F,Gomi F,Itakura Y,Nakamura N,Toyoda M,Ishiwata T
Wed Dec 18 00:00:00 UTC 2019
Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells.
Scientific reports
Cai BH,Wu PH,Chou CK,Huang HC,Chao CC,Chung HY,Lee HY,Chen JY,Kannagi R
Wed Jan 30 00:00:00 UTC 2019
Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters.
Frontiers in immunology
Li W,Qu G,Choi SC,Cornaby C,Titov A,Kanda N,Teng X,Wang H,Morel L
100-21 was used in Cell Culture to suggest that blocking glucose uptake with a small molecule inhibitor ameliorates autoimmune activation, at least partially due to its inhibition of glycolysis in CD4+ T cells.
Thu Sep 24 00:00:00 UTC 2020
P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
Communications biology
Schiff L,Boles NC,Fernandes M,Nachmani B,Gentile R,Blenkinsop TA
Mon Apr 20 00:00:00 UTC 2020
Characterization of polydactyly chondrocytes and their use in cartilage engineering.
Scientific reports
Cavalli E,Levinson C,Hertl M,Broguiere N,Brück O,Mustjoki S,Gerstenberg A,Weber D,Salzmann G,Steinwachs M,Barreto G,Zenobi-Wong M
Tue Mar 12 00:00:00 UTC 2019
Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor.
PloS one
Hammond CL,Roztocil E,Phipps RP,Feldon SE,Woeller CF
100-21 was used in Cell Culture to show that the proton pump inhibitors (PPIs), esomeprazole and lansoprazole, can prevent transforming growth factor beta (TGFβ)-mediated differentiation of TED orbital fibroblasts to myofibroblasts, a critical step in scar formation.
Mon Mar 23 00:00:00 UTC 2020
Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice.
Scientific reports
Takagaki Y,Shi S,Katoh M,Kitada M,Kanasaki K,Koya D
Fri May 17 00:00:00 UTC 2019
Long non-coding RNA Taurine upregulated gene 1 promotes osteosarcoma cell metastasis by mediating HIF-1α via miR-143-5p.
Cell death & disease
Yu X,Hu L,Li S,Shen J,Wang D,Xu R,Yang H
Mon Mar 25 00:00:00 UTC 2019
Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Moratal C,Arrighi N,Dechesne CA,Dani C
100-21 was used in Cell Culture to investigate the role of human myogenic progenitors in the regulation of human fibro-adipogenic progenitors.
Tue Jan 07 00:00:00 UTC 2020
Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.
Scientific reports
Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA
Thu Jun 20 00:00:00 UTC 2019
Deciphering the complex role of thrombospondin-1 in glioblastoma development.
Nature communications
Daubon T,Léon C,Clarke K,Andrique L,Salabert L,Darbo E,Pineau R,Guérit S,Maitre M,Dedieu S,Jeanne A,Bailly S,Feige JJ,Miletic H,Rossi M,Bello L,Falciani F,Bjerkvig R,Bikfalvi A
Fri Mar 08 00:00:00 UTC 2019
Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells.
Nature communications
Estève D,Boulet N,Belles C,Zakaroff-Girard A,Decaunes P,Briot A,Veeranagouda Y,Didier M,Remaury A,Guillemot JC,Ledoux S,Dani C,Bouloumié A,Galitzky J
Tue Jun 11 00:00:00 UTC 2019
Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.
The Journal of biological chemistry
Yin W,Song Y,Chang X
Fri Jan 04 00:00:00 UTC 2019
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.
Stem cell reports
Kelleher J,Dickinson A,Cain S,Hu Y,Bates N,Harvey A,Ren J,Zhang W,Moreton FC,Muir KW,Ward C,Touyz RM,Sharma P,Xu Q,Kimber SJ,Wang T
Tue Nov 12 00:00:00 UTC 2019
Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.
Scientific reports
Bonne-Année S,Bush MC,Nutman TB
Fri Oct 04 00:00:00 UTC 2019
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
The Journal of biological chemistry
Frossi B,Antoniali G,Yu K,Akhtar N,Kaplan MH,Kelley MR,Tell G,Pucillo CEM
Fri Mar 29 00:00:00 UTC 2019
Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3.
Scientific reports
Choi HI,Kim DH,Park JS,Kim IJ,Kim CS,Bae EH,Ma SK,Lee TH,Kim SW
Wed Jun 19 00:00:00 UTC 2019
Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations.
Theranostics
Hamad S,Derichsweiler D,Papadopoulos S,Nguemo F,Šarić T,Sachinidis A,Brockmeier K,Hescheler J,Boukens BJ,Pfannkuche K
100-21 was used in Cell Culture to show that batch-to-batch variations were reduced by combinatorial use of ascorbate, IWP2, and XAV939. Conclusion: Combined inhibition of porcupine and tankyrase sub-pathways of Wnt signaling and continuous ascorbate supplementation, enable robust and efficient production of hiPSC-CMs.
Fri Sep 11 00:00:00 UTC 2020
Identification of SERPINE1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling.
Cancers
Seker F,Cingoz A,Sur-Erdem İ,Erguder N,Erkent A,Uyulur F,Esai Selvan M,Gümüş ZH,Gönen M,Bayraktar H,Wakimoto H,Bagci-Onder T
100-21 was used in Cell Culture to analyze transcriptome of motile (dispersive) and non-motile (core) glioblastoma (GBM) cells using an in vitro spheroid dispersal model and identify SERPINE1 as a modulator of GBM cell dispersal, providing insight for future anti-invasive therapy design.
Fri Oct 25 00:00:00 UTC 2019
Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate.
eLife
Cibi DM,Mia MM,Guna Shekeran S,Yun LS,Sandireddy R,Gupta P,Hota M,Sun L,Ghosh S,Singh MK
100-21 was used in Sample Preparation (Western Blotting) to demonstrate that splicing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCCs leads to cleft palate and defects in craniofacial bone development and identify a positive feedback loop in which TGF-β signaling promotes expression of Rbfox2 in NCCs.
Wed Jun 26 00:00:00 UTC 2019
TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors.
Nature communications
Guerin MV,Regnier F,Feuillet V,Vimeux L,Weiss JM,Bismuth G,Altan-Bonnet G,Guilbert T,Thoreau M,Finisguerra V,Donnadieu E,Trautmann A,Bercovici N
Wed Sep 11 00:00:00 UTC 2019
Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression.
Cell death & disease
Hasselluhn MC,Schmidt GE,Ellenrieder V,Johnsen SA,Hessmann E
Thu Jun 06 00:00:00 UTC 2019
Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells.
Scientific reports
Bertolo A,Baur M,Guerrero J,Pötzel T,Stoyanov J
Thu Feb 14 00:00:00 UTC 2019
Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Brauer E,Lippens E,Klein O,Nebrich G,Schreivogel S,Korus G,Duda GN,Petersen A
Fri May 03 00:00:00 UTC 2019
TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.
Scientific reports
Kanda A,Noda K,Hirose I,Ishida S
Thu Jan 24 00:00:00 UTC 2019
Swainsonine inhibits proliferation and collagen synthesis of NIH-3T3 cells by declining miR-21.
Artificial cells, nanomedicine, and biotechnology
Li C,Wang P,Fu Z,Li Y,Li S
100-21 was used in Cell Culture to explore the effects of SW on mouse embryo fibroblast NIH-3T3 cell proliferation and collagen synthesis, as well as potential molecule mechanisms.
Sun Dec 01 00:00:00 UTC 2019
Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.
Developmental cell
Sozen B,Cox AL,De Jonghe J,Bao M,Hollfelder F,Glover DM,Zernicka-Goetz M
100-21 was used in Cell Culture to show that mouse embryonic stem cells cultured under extended pluripotent conditions (EPSCs) can be partnered with trophoblast stem cells to self-organize into blastocyst-like structures with all three embryonic and extra-embryonic lineages.
Mon Dec 16 00:00:00 UTC 2019
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling.
Nature communications
Batlle R,Andrés E,Gonzalez L,Llonch E,Igea A,Gutierrez-Prat N,Berenguer-Llergo A,Nebreda AR
Thu Jul 11 00:00:00 UTC 2019
Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer.
International journal of molecular sciences
Chang WF,Wu YH,Xu J,Sung LY
100-21 was used in In vitro experiments to investigate the germ layer development competence of Terc-/-, Terc+/- and wild-type (Terc+/+) ntESCs.
Tue Mar 12 00:00:00 UTC 2019
TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome.
Aging
You W,Hong Y,He H,Huang X,Tao W,Liang X,Zhang Y,Li X
100-21 was used in Sample Preparation to investigate TGF-β signalling in Marfan syndrome.
Thu May 30 00:00:00 UTC 2019
CD271-selected mesenchymal stem cells from adipose tissue enhance cartilage repair and are less angiogenic than plastic adherent mesenchymal stem cells.
Scientific reports
Kohli N,Al-Delfi IRT,Snow M,Sakamoto T,Miyazaki T,Nakajima H,Uchida K,Johnson WEB
Thu Feb 28 00:00:00 UTC 2019
circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.
Cell death & disease
Zhang JX,Lu J,Xie H,Wang DP,Ni HE,Zhu Y,Ren LH,Meng XX,Wang RL
Fri Feb 22 00:00:00 UTC 2019
Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.
Scientific reports
Pecha S,Yorgan K,Röhl M,Geertz B,Hansen A,Weinberger F,Sehner S,Ehmke H,Reichenspurner H,Eschenhagen T,Schwoerer AP
Mon Jul 08 00:00:00 UTC 2019
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
The Journal of biological chemistry
Dupont L,Du L,Poulter M,Choi S,McIntosh M,Reeves MB
Fri Aug 30 00:00:00 UTC 2019
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
eLife
Achberger K,Probst C,Haderspeck J,Bolz S,Rogal J,Chuchuy J,Nikolova M,Cora V,Antkowiak L,Haq W,Shen N,Schenke-Layland K,Ueffing M,Liebau S,Loskill P
100-21 was used in Cell Culture to show that this interaction enhances the formation of outer segment-like structures and the establishment of in vivo-like physiological processes such as outer segment phagocytosis and calcium dynamics.
Tue Aug 27 00:00:00 UTC 2019
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity.
eLife
Martinez-Fabregas J,Wilmes S,Wang L,Hafer M,Pohler E,Lokau J,Garbers C,Cozzani A,Fyfe PK,Piehler J,Kazemian M,Mitra S,Moraga I
100-21 was used in Sample Preparation (FC/FACS) to show that the elucidation of additional resistance mechanisms beyond the PD-1/PD-L1 axis will constitute an important milestone for our understanding of factors determining tumor escape and deepening of TCB anti-tumor responses in both solid tumors and hematological disorders.
Wed Nov 27 00:00:00 UTC 2019
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 UTC 2018
Blastocyst-like structures generated solely from stem cells.
Nature
Rivron NC,Frias-Aldeguer J,Vrij EJ,Boisset JC,Korving J,Vivié J,Truckenmüller RK,van Oudenaarden A,van Blitterswijk CA,Geijsen N
Tue May 01 00:00:00 UTC 2018
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.
Cell
van Dijk D,Sharma R,Nainys J,Yim K,Kathail P,Carr AJ,Burdziak C,Moon KR,Chaffer CL,Pattabiraman D,Bierie B,Mazutis L,Wolf G,Krishnaswamy S,Pe'er D
Thu Jul 26 00:00:00 UTC 2018
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.
Immunity
Li S,Bostick JW,Ye J,Qiu J,Zhang B,Urban JF,Avram D,Zhou L
Tue Nov 20 00:00:00 UTC 2018
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Immunity
Tyagi AM,Yu M,Darby TM,Vaccaro C,Li JY,Owens JA,Hsu E,Adams J,Weitzmann MN,Jones RM,Pacifici R
Tue Dec 18 00:00:00 UTC 2018
Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity.
International journal of oral science
Asparuhova MB,Caballé-Serrano J,Buser D,Chappuis V
Tue Jun 12 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.
The Journal of experimental medicine
Guan T,Dominguez CX,Amezquita RA,Laidlaw BJ,Cheng J,Henao-Mejia J,Williams A,Flavell RA,Lu J,Kaech SM
Mon Apr 02 00:00:00 UTC 2018
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.
The Journal of experimental medicine
Kelly A,Gunaltay S,McEntee CP,Shuttleworth EE,Smedley C,Houston SA,Fenton TM,Levison S,Mann ER,Travis MA
Mon Nov 05 00:00:00 UTC 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 UTC 2018
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.
Hepatology (Baltimore, Md.)
Lu M,Wu J,Hao ZW,Shang YK,Xu J,Nan G,Li X,Chen ZN,Bian H
100-21 was used in In vitro experiments to show that cluster of differentiation 147 (CD147) is basolaterally polarized in hepatocyte membrane of liver tissues and HepG2 cells.
Sun Jul 01 00:00:00 UTC 2018
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America
Sen S,Wang F,Zhang J,He Z,Ma J,Gwack Y,Xu J,Sun Z
Tue Jan 16 00:00:00 UTC 2018
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.
Experimental & molecular medicine
Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT
Wed Dec 12 00:00:00 UTC 2018
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.
Experimental & molecular medicine
Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT
Wed Dec 12 00:00:00 UTC 2018
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.
Cell death and differentiation
Bellomo C,Caja L,Fabregat I,Mikulits W,Kardassis D,Heldin CH,Moustakas A
Tue May 01 00:00:00 UTC 2018
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
PLoS biology
Huang S,Park J,Qiu C,Chung KW,Li SY,Sirin Y,Han SH,Taylor V,Zimber-Strobl U,Susztak K
100-21 was used in In vitro experiments to study that JAG1 and NOTCH2 show the strongest correlation with the degree of interstitial fibrosis in a genome-wide expression analysis of a large cohort of human kidney samples.
Sat Sep 01 00:00:00 UTC 2018
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
PLoS biology
Huang S,Park J,Qiu C,Chung KW,Li SY,Sirin Y,Han SH,Taylor V,Zimber-Strobl U,Susztak K
100-21 was used in In vitro experiments to study that JAG1 and NOTCH2 show the strongest correlation with the degree of interstitial fibrosis in a genome-wide expression analysis of a large cohort of human kidney samples.
Sat Sep 01 00:00:00 UTC 2018
Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling.
Science signaling
Bian G,Yu C,Liu L,Fang C,Chen K,Ren P,Zhang Q,Liu F,Zhang K,Xue Q,Xiang J,Guo H,Song J,Zhao Y,Wu W,Chung SK,Sun R,Ju G,Wang J
Tue Oct 23 00:00:00 UTC 2018
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Frontiers in immunology
Cobbold SP,Adams E,Howie D,Waldmann H
100-21 was used in Cell Culture to develop an in vitro model of T cell differentiation suited to testing how manipulation of components of the microenvironment might be therapeutically exploited.
Mon Jan 31 00:00:00 UTC 2022
Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.
Oncogene
Caja L,Tzavlaki K,Dadras MS,Tan EJ,Hatem G,Maturi NP,Morén A,Wik L,Watanabe Y,Savary K,Kamali-Moghaddan M,Uhrbom L,Heldin CH,Moustakas A
Tue May 01 00:00:00 UTC 2018
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Oncogenesis
Veenstra VL,Damhofer H,Waasdorp C,van Rijssen LB,van de Vijver MJ,Dijk F,Wilmink HW,Besselink MG,Busch OR,Chang DK,Bailey PJ,Biankin AV,Kocher HM,Medema JP,Li JS,Jiang R,Pierce DW,van Laarhoven HWM,Bijlsma MF
Fri Nov 16 00:00:00 UTC 2018
Aberrant methylation of EYA4 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Cancer science
Luo M,Li Y,Shi X,Yang W,Zhou F,Sun N,He J
Fri Jun 01 00:00:00 UTC 2018
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
American journal of physiology. Lung cellular and molecular physiology
Jiang H,Chen Y,Yu T,Zhao X,Shan H,Sun J,Zhang L,Li X,Shan H,Liang H
Mon Oct 01 00:00:00 UTC 2018
Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.
The American journal of pathology
Ohmaru-Nakanishi T,Asanoma K,Fujikawa M,Fujita Y,Yagi H,Onoyama I,Hidaka N,Sonoda K,Kato K
100-21 was used in Cell Culture to suggest that TGFB1 signaling is activated in the fibroblasts in PE placentas and that these active fibroblasts contribute to fibrosis.
Thu Mar 01 00:00:00 UTC 2018
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
Journal of immunology (Baltimore, Md. : 1950)
Woo JS,Srikanth S,Kim KD,Elsaesser H,Lu J,Pellegrini M,Brooks DG,Sun Z,Gwack Y
Wed Aug 15 00:00:00 UTC 2018
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
Journal of immunology (Baltimore, Md. : 1950)
Bian J,Liu R,Fan T,Liao L,Wang S,Geng W,Wang T,Shi W,Ruan Q
Sat Sep 01 00:00:00 UTC 2018
The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Caron R,Seeley JJ,De Silva NS,Schindler CW,Hayden MS,Klein U,Ghosh S
Sun Apr 01 00:00:00 UTC 2018
TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Grunwell JR,Yeligar SM,Stephenson S,Ping XD,Gauthier TW,Fitzpatrick AM,Brown LAS
Thu Mar 15 00:00:00 UTC 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 UTC 2018
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Journal of immunology (Baltimore, Md. : 1950)
Kalim KW,Yang JQ,Li Y,Meng Y,Zheng Y,Guo F
Sun Apr 01 00:00:00 UTC 2018
Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Choi SC,Xu Z,Li W,Yang H,Roopenian DC,Morse HC,Morel L
Tue May 01 00:00:00 UTC 2018
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun IH,Oh MH,Zhao L,Patel CH,Arwood ML,Xu W,Tam AJ,Blosser RL,Wen J,Powell JD
Sun Jul 15 00:00:00 UTC 2018
A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Liu W,Chen Y,Liu J,Wu K,Su L,Zhang W,Jiang Y,Zhang X,Zhang Y,Liu C,Tao L,Liu B,Zhang H
Thu Feb 01 00:00:00 UTC 2018
hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF‑β signaling.
International journal of molecular medicine
Chen W,Shin KH,Kim S,Shon WJ,Kim RH,Park NH,Kang MK
100-21 was used in In vitro experiments to demonstrate the radioprotective and antifibrotic effects of GV1001 by suppressing transforming growth factor‚β (TGF‚β) signaling.
Fri Jun 01 00:00:00 UTC 2018
LncRNA UCA1 is necessary for TGF-β-induced epithelial-mesenchymal transition and stemness via acting as a ceRNA for Slug in glioma cells.
FEBS open bio
Li Z,Liu H,Zhong Q,Wu J,Tang Z
Thu Nov 01 00:00:00 UTC 2018
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
100-21 was used in Cell Culture to explore the mechanism of regulatory T cell/Th17 imbalance and the role of high mobility group box-1 protein on the balance in atherosclerosis.
Sat Sep 01 00:00:00 UTC 2018
3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis.
Scientific reports
Kim TH,Choi JH,Jun Y,Lim SM,Park S,Paek JY,Lee SH,Hwang JY,Kim GJ
Wed Oct 17 00:00:00 UTC 2018
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Scientific reports
Kim KH,Kim SH,Han DH,Jo YS,Lee YH,Lee MS
Tue May 01 00:00:00 UTC 2018
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Scientific reports
Kim KH,Kim SH,Han DH,Jo YS,Lee YH,Lee MS
Tue May 01 00:00:00 UTC 2018
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Nature communications
Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q
Thu Feb 08 00:00:00 UTC 2018
The microRNA regulatory landscape of MSC-derived exosomes: a systems view.
Scientific reports
Ferguson SW,Wang J,Lee CJ,Liu M,Neelamegham S,Canty JM,Nguyen J
Tue Jan 23 00:00:00 UTC 2018
Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts.
Scientific reports
Liguori TTA,Liguori GR,Moreira LFP,Harmsen MC
Fri Nov 09 00:00:00 UTC 2018
TGF-β1-SOX9 axis-inducible COL10A1 promotes invasion and metastasis in gastric cancer via epithelial-to-mesenchymal transition.
Cell death & disease
Li T,Huang H,Shi G,Zhao L,Li T,Zhang Z,Liu R,Hu Y,Liu H,Yu J,Li G
Tue Aug 28 00:00:00 UTC 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
Tue Jul 10 00:00:00 UTC 2018
Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling.
Oncotarget
Barnhouse VR,Weist JL,Shukla VC,Ghadiali SN,Kniss DA,Leight JL
100-21 was used in Cell Culture to study the role of Myoferlin (MYOF) protein overexpression in invasive cancer cell lines to identify a novel pathway in the regulation of autocrine TGF-β signaling and a mechanism by which MYOF regulates cellular phenotype and invasive capacity of human breast cancer cells.
Tue Apr 10 00:00:00 UTC 2018
MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME.
Stem cell reports
Zhang L,Wang H,Liu C,Wu Q,Su P,Wu D,Guo J,Zhou W,Xu Y,Shi L,Zhou J
Tue Aug 14 00:00:00 UTC 2018
Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts.
Scientific reports
Patel B,Xu Z,Pinnock CB,Kabbani LS,Lam MT
Mon Feb 19 00:00:00 UTC 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
Wed Sep 26 00:00:00 UTC 2018
Expression of tenascin-C in a rat vocal fold injury model and its regulation of fibroblasts.
The Laryngoscope
Li J,Liu Y,Wang Y,Xu W
100-21 was used in In vitro experiments to investigate Tnc expression in a rat vocal fold injury model in vivo and its roles in fibroblasts in vitro.
Sat Sep 01 00:00:00 UTC 2018
Single cell analysis of kynurenine and System L amino acid transport in T cells.
Nature communications
Sinclair LV,Neyens D,Ramsay G,Taylor PM,Cantrell DA
Thu May 17 00:00:00 UTC 2018
Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.
Cell death & disease
Lv Q,Shi C,Qiao S,Cao N,Guan C,Dai Y,Wei Z
Thu Aug 30 00:00:00 UTC 2018
Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer.
APL bioengineering
Jolly MK,Preca BT,Tripathi SC,Jia D,George JT,Hanash SM,Brabletz T,Stemmler MP,Maurer J,Levine H
100-21 was used in Cell Culture to investigate EMT regulation.
Sat Sep 01 00:00:00 UTC 2018
Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis.
Scientific reports
Cao H,Wang C,Chen X,Hou J,Xiang Z,Shen Y,Han X
Tue Sep 11 00:00:00 UTC 2018
Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis.
Scientific reports
Cao H,Wang C,Chen X,Hou J,Xiang Z,Shen Y,Han X
Tue Sep 11 00:00:00 UTC 2018
Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats.
Scientific reports
Tong WW,Zhang C,Hong T,Liu DH,Wang C,Li J,He XK,Xu WD
Mon Feb 19 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells.
The Journal of biological chemistry
Tian B,Widen SG,Yang J,Wood TG,Kudlicki A,Zhao Y,Brasier AR
Fri Oct 19 00:00:00 UTC 2018
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Nature communications
Zehender A,Huang J,Györfi AH,Matei AE,Trinh-Minh T,Xu X,Li YN,Chen CW,Lin J,Dees C,Beyer C,Gelse K,Zhang ZY,Bergmann C,Ramming A,Birchmeier W,Distler O,Schett G,Distler JHW
Tue Aug 14 00:00:00 UTC 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Nature communications
Schubert M,Klinger B,Klünemann M,Sieber A,Uhlitz F,Sauer S,Garnett MJ,Blüthgen N,Saez-Rodriguez J
Tue Jan 02 00:00:00 UTC 2018
Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.
Stem cell research & therapy
Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C
100-21 was used in In vitro experiments to report the expression, functions, and molecular interactions of deer thymosin beta 10 (TMSB10) in tissue and cells in antler growth.
Tue Jun 19 00:00:00 UTC 2018
SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis.
Cell death & disease
Srivastava SP,Li J,Kitada M,Fujita H,Yamada Y,Goodwin JE,Kanasaki K,Koya D
Mon Sep 24 00:00:00 UTC 2018
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
eLife
Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R
100-21 was used in Cell Culture to examine the role of glutamine catabolism in fuelling the de novo synthesis of glutathionine, and directing the lineage choice of T cells.
Mon Sep 10 00:00:00 UTC 2018
PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.
Cell death & disease
Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q
Thu Feb 22 00:00:00 UTC 2018
CTHRC1 overexpression predicts poor survival and enhances epithelial-mesenchymal transition in colorectal cancer.
Cancer medicine
Ni S,Ren F,Xu M,Tan C,Weng W,Huang Z,Sheng W,Huang D
Thu Nov 01 00:00:00 UTC 2018
The oligosaccharides 6'-sialyllactose, 2'-fucosyllactose or galactooligosaccharides do not directly modulate human dendritic cell differentiation or maturation.
PloS one
Perdijk O,van Neerven RJJ,van den Brink E,Savelkoul HFJ,Brugman S
100-21 was used in Cell Culture to study the effect of human milk oligosaccharides (HMOs) 6'-sialyllactose (6'SL) and 2'-fucosyllactose (2'FL) as well as prebiotic galactooligosaccharides (GOS) on dendritic cell (DC) differentiation and maturation to study how HMOs contribute to immune homeostasis and protection against disease.
Tue Jan 22 00:00:00 UTC 2019
Glycolysis promotes caspase-3 activation in lipid rafts in T cells.
Cell death & disease
Secinaro MA,Fortner KA,Dienz O,Logan A,Murphy MP,Anathy V,Boyson JE,Budd RC
Fri Jan 19 00:00:00 UTC 2018
Fate of mesoangioblasts in a vaginal birth injury model: influence of the route of administration.
Scientific reports
Mori da Cunha MGMC,Giacomazzi G,Callewaert G,Hympanova L,Russo F,Vande Velde G,Gijsbers R,Albersen M,Sampaolesi M,Deprest J
Fri Jul 13 00:00:00 UTC 2018
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.
Nature communications
Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K
Tue Oct 30 00:00:00 UTC 2018
A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.
Nature communications
Petersen A,Princ A,Korus G,Ellinghaus A,Leemhuis H,Herrera A,Klaumünzer A,Schreivogel S,Woloszyk A,Schmidt-Bleek K,Geissler S,Heschel I,Duda GN
Thu Oct 25 00:00:00 UTC 2018
Excessive periostin expression and Th2 response in patients with nasal polyps: association with asthma.
Journal of thoracic disease
Wei Y,Ma R,Zhang J,Wu X,Yu G,Hu X,Li J,Liu Z,Ji W,Li H,Wen W
100-21 was used in Cell Culture to indicate periostin may play an important role in the polyp genesis, which can be considered as a therapeutic target for the management of chronic rhinosinusitis with nasal polyps.
Sat Dec 01 00:00:00 UTC 2018
Chromobodies to Quantify Changes of Endogenous Protein Concentration in Living Cells.
Molecular & cellular proteomics : MCP
Keller BM,Maier J,Secker KA,Egetemaier SM,Parfyonova Y,Rothbauer U,Traenkle B
Sat Dec 01 00:00:00 UTC 2018
Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression.
Cell death & disease
Rani B,Malfettone A,Dituri F,Soukupova J,Lupo L,Mancarella S,Fabregat I,Giannelli G
Wed Mar 07 00:00:00 UTC 2018
Injury-activated glial cells promote wound healing of the adult skin in mice.
Nature communications
Parfejevs V,Debbache J,Shakhova O,Schaefer SM,Glausch M,Wegner M,Suter U,Riekstina U,Werner S,Sommer L
Tue Jan 16 00:00:00 UTC 2018
Injury-activated glial cells promote wound healing of the adult skin in mice.
Nature communications
Parfejevs V,Debbache J,Shakhova O,Schaefer SM,Glausch M,Wegner M,Suter U,Riekstina U,Werner S,Sommer L
Tue Jan 16 00:00:00 UTC 2018
Cardiac (myo)fibroblasts modulate the migration of monocyte subsets.
Scientific reports
Pappritz K,Savvatis K,Koschel A,Miteva K,Tschöpe C,Van Linthout S
Tue Apr 03 00:00:00 UTC 2018
Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms.
Scientific reports
Pan Y,Liu L,Li S,Wang K,Ke R,Shi W,Wang J,Yan X,Zhang Q,Wang Q,Chai L,Xie X,Li M
Mon Feb 26 00:00:00 UTC 2018
Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis.
Cell death & disease
Wu YH,Lee YH,Shih HY,Chen SH,Cheng YC,Tsun-Yee Chiu D
Tue Jan 09 00:00:00 UTC 2018
Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion.
Cell death & disease
Shao T,Song P,Hua H,Zhang H,Sun X,Kong Q,Wang J,Luo T,Jiang Y
Thu May 24 00:00:00 UTC 2018
A novel mechanism of plasminogen activation in epithelial and mesenchymal cells.
Scientific reports
Bydoun M,Sterea A,Weaver ICG,Bharadwaj AG,Waisman DM
Thu Sep 20 00:00:00 UTC 2018
The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.
Oncotarget
Uschner FE,Schueller F,Nikolova I,Klein S,Schierwagen R,Magdaleno F,Gröschl S,Loosen S,Ritz T,Roderburg C,Vucur M,Kristiansen G,Lammers T,Luedde T,Trebicka J
100-21 was used in Sample Preparation (FC/FACS) to study the effects of regorafenib in experimental models without hepatocellular carcinoma to investigate if regorafenib is beneficial in fibrosis and portal hypertension (PHT) even in absence of HCC.
Fri Nov 16 00:00:00 UTC 2018
The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.
Oncotarget
Uschner FE,Schueller F,Nikolova I,Klein S,Schierwagen R,Magdaleno F,Gröschl S,Loosen S,Ritz T,Roderburg C,Vucur M,Kristiansen G,Lammers T,Luedde T,Trebicka J
100-21 was used in Sample Preparation (FC/FACS) to study the effects of regorafenib in experimental models without hepatocellular carcinoma to investigate if regorafenib is beneficial in fibrosis and portal hypertension (PHT) even in absence of HCC.
Fri Nov 16 00:00:00 UTC 2018
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Sat Apr 01 00:00:00 UTC 2017
The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages.
Immunity
Yu X,Buttgereit A,Lelios I,Utz SG,Cansever D,Becher B,Greter M
Tue Nov 21 00:00:00 UTC 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
Tue Dec 19 00:00:00 UTC 2017
Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
Cell metabolism
Rios Garcia M,Steinbauer B,Srivastava K,Singhal M,Mattijssen F,Maida A,Christian S,Hess-Stumpp H,Augustin HG,Müller-Decker K,Nawroth PP,Herzig S,Berriel Diaz M
100-21 was used in Cell Culture to define the lipogenic enzyme acetyl-CoA carboxylase (ACC) 1 as a key player in breast cancer metastasis and demonstrate the effectiveness of anti-leptin receptor antibody treatment in halting ACC1-dependent tumor invasiveness.
Tue Dec 05 00:00:00 UTC 2017
Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
Cell metabolism
Rios Garcia M,Steinbauer B,Srivastava K,Singhal M,Mattijssen F,Maida A,Christian S,Hess-Stumpp H,Augustin HG,Müller-Decker K,Nawroth PP,Herzig S,Berriel Diaz M
100-21 was used in Cell Culture to define the lipogenic enzyme acetyl-CoA carboxylase (ACC) 1 as a key player in breast cancer metastasis and demonstrate the effectiveness of anti-leptin receptor antibody treatment in halting ACC1-dependent tumor invasiveness.
Tue Dec 05 00:00:00 UTC 2017
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.
Nature cell biology
Krebs AM,Mitschke J,Lasierra Losada M,Schmalhofer O,Boerries M,Busch H,Boettcher M,Mougiakakos D,Reichardt W,Bronsert P,Brunton VG,Pilarsky C,Winkler TH,Brabletz S,Stemmler MP,Brabletz T
100-21 was used in Cell Culture to study role of epithelial-to-mesenchymal transition (EMT) in promoting metastasis to conclude that different EMT-transcription factors (TFs) have complementary subfunctions in driving pancreatic tumour metastasis.
Mon May 01 00:00:00 UTC 2017
T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD.
Blood
Dant TA,Lin KL,Bruce DW,Montgomery SA,Kolupaev OV,Bommiasamy H,Bixby LM,Woosley JT,McKinnon KP,Gonzalez FJ,Blazar BR,Vincent BG,Coghill JM,Serody JS
Thu Jul 20 00:00:00 UTC 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
100-21 was used in Cell Culture to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 UTC 2017
Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.
Cell stem cell
Guimarães-Camboa N,Cattaneo P,Sun Y,Moore-Morris T,Gu Y,Dalton ND,Rockenstein E,Masliah E,Peterson KL,Stallcup WB,Chen J,Evans SM
100-21 was used in Cell Culture to study the cell fate plasticity of endogenous pericytes in vivo to show that the transcription factor Tbx18 selectively marks pericytes and vascular smooth muscle cells in multiple organs of adult mouse.
Thu Mar 02 00:00:00 UTC 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
Mon Oct 02 00:00:00 UTC 2017
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
The Journal of clinical investigation
Wei Y,Kim TJ,Peng DH,Duan D,Gibbons DL,Yamauchi M,Jackson JR,Le Saux CJ,Calhoun C,Peters J,Derynck R,Backes BJ,Chapman HA
Mon Oct 02 00:00:00 UTC 2017
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
The Journal of clinical investigation
Wei Y,Kim TJ,Peng DH,Duan D,Gibbons DL,Yamauchi M,Jackson JR,Le Saux CJ,Calhoun C,Peters J,Derynck R,Backes BJ,Chapman HA
Mon Oct 02 00:00:00 UTC 2017
TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.
The Journal of experimental medicine
Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V
Mon May 01 00:00:00 UTC 2017
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
Developmental cell
Bajikar SS,Wang CC,Borten MA,Pereira EJ,Atkins KA,Janes KA
100-21 was used in Cell Culture to study the tumour-suppressive mode of action of growth-differentiation factor 11, and an unusual mechanism of its inactivation in triple negative breast cancer.
Mon Nov 20 00:00:00 UTC 2017
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.
Proceedings of the National Academy of Sciences of the United States of America
Mills RJ,Titmarsh DM,Koenig X,Parker BL,Ryall JG,Quaife-Ryan GA,Voges HK,Hodson MP,Ferguson C,Drowley L,Plowright AT,Needham EJ,Wang QD,Gregorevic P,Xin M,Thomas WG,Parton RG,Nielsen LK,Launikonis BS,James DE,Elliott DA,Porrello ER,Hudson JE
Tue Oct 03 00:00:00 UTC 2017
Sensing relative signal in the Tgf-β/Smad pathway.
Proceedings of the National Academy of Sciences of the United States of America
Frick CL,Yarka C,Nunns H,Goentoro L
100-21 was used in In vitro experiments to show that, using single-molecule FISH, we further observed that expression of Smad3 target genes (ctgf, snai1, and wnt9a) correlated more strongly with the fold change, rather than the level, of nuclear Smad3.
Tue Apr 04 00:00:00 UTC 2017
Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America
Nguyen HV,Dong J,Panchakshari RA,Kumar V,Alt FW,Bories JC
Tue Dec 05 00:00:00 UTC 2017
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases.
Experimental & molecular medicine
Bansal R,Nakagawa S,Yazdani S,van Baarlen J,Venkatesh A,Koh AP,Song WM,Goossens N,Watanabe H,Beasley MB,Powell CA,Storm G,Kaminski N,van Goor H,Friedman SL,Hoshida Y,Prakash J
Fri Nov 17 00:00:00 UTC 2017
TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.
Cell death and differentiation
Cammareri P,Vincent DF,Hodder MC,Ridgway RA,Murgia C,Nobis M,Campbell AD,Varga J,Huels DJ,Subramani C,Prescott KLH,Nixon C,Hedley A,Barry ST,Greten FR,Inman GJ,Sansom OJ
Sun Oct 01 00:00:00 UTC 2017
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification.
Cell death and differentiation
Vicinanza C,Aquila I,Scalise M,Cristiano F,Marino F,Cianflone E,Mancuso T,Marotta P,Sacco W,Lewis FC,Couch L,Shone V,Gritti G,Torella A,Smith AJ,Terracciano CM,Britti D,Veltri P,Indolfi C,Nadal-Ginard B,Ellison-Hughes GM,Torella D
Fri Dec 01 00:00:00 UTC 2017
Estradiol Promotes Breast Cancer Cell Migration via Recruitment and Activation of Neutrophils.
Cancer immunology research
Vazquez Rodriguez G,Abrahamsson A,Jensen LD,Dabrosin C
100-21 was used in Cell Culture to indicate that extracellular TGFβ1 is a relevant target in human breast cancer.
Wed Mar 01 00:00:00 UTC 2017
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.
Cellular and molecular gastroenterology and hepatology
Chuvin N,Vincent DF,Pommier RM,Alcaraz LB,Gout J,Caligaris C,Yacoub K,Cardot V,Roger E,Kaniewski B,Martel S,Cintas C,Goddard-Léon S,Colombe A,Valantin J,Gadot N,Servoz E,Morton J,Goddard I,Couvelard A,Rebours V,Guillermet J,Sansom OJ,Treilleux I,Valcourt U,Sentis S,Dubus P,Bartholin L
100-21 was used in In vitro experiments to demonstrate that TGFβ pathway activation plays a crucial role in pancreatic tumor initiation through its capacity to induce acinar-to-ductal metaplasia.
Fri Sep 01 00:00:00 UTC 2017
Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells.
Frontiers in immunology
Lerrer S,Liubomirski Y,Bott A,Abnaof K,Oren N,Yousaf A,Körner C,Meshel T,Wiemann S,Ben-Baruch A
100-21 was used in Cell Culture to demonstrate a TNFα + TGFβ1-driven pro-inflammatory fate in MSCs, identify specific molecular mechanisms involved, and propose that TNFα + TGFβ1-stimulated MSCs influence the tumor niche.
Fri May 31 00:00:00 UTC 2024
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 UTC 2017
Stromal SPOCK1 supports invasive pancreatic cancer growth.
Molecular oncology
Veenstra VL,Damhofer H,Waasdorp C,Steins A,Kocher HM,Medema JP,van Laarhoven HW,Bijlsma MF
Tue Aug 01 00:00:00 UTC 2017
Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.
Cancer science
Tong Y,Yang H,Xu X,Ruan J,Liang M,Wu J,Luo B
Sat Apr 01 00:00:00 UTC 2017
microRNA-219-5p inhibits epithelial-mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer-binding factor 1.
Cancer science
Huang LX,Hu CY,Jing L,Wang MC,Xu M,Wang J,Wang Y,Nan KJ,Wang SH
Sun Oct 01 00:00:00 UTC 2017
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.
Immunology and cell biology
Alberdi M,Iglesias M,Tejedor S,Merino R,López-Rodríguez C,Aramburu J
100-21 was used in Cell Culture to show that NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.
Sun Jan 01 00:00:00 UTC 2017
Enrichment of Human CCR6+ Regulatory T Cells with Superior Suppressive Activity in Oral Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Lee JJ,Kao KC,Chiu YL,Jung CJ,Liu CJ,Cheng SJ,Chang YL,Ko JY,Chia JS
Sat Jul 15 00:00:00 UTC 2017
Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hutton AJ,Polak ME,Spalluto CM,Wallington JC,Pickard C,Staples KJ,Warner JA,Wilkinson TM
Sun Jan 01 00:00:00 UTC 2017
STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Mice.
Journal of immunology (Baltimore, Md. : 1950)
Taghavie-Moghadam PL,Waseem TC,Hattler J,Glenn LM,Dobrian AD,Kaplan MH,Yang Y,Nurieva R,Nadler JL,Galkina EV
Wed Nov 15 00:00:00 UTC 2017
Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA
Sun Jan 01 00:00:00 UTC 2017
A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D
Sat Jul 15 00:00:00 UTC 2017
The TGF-β-induced up-regulation of NKG2DLs requires AKT/GSK-3β-mediated stabilization of SP1.
Journal of cellular and molecular medicine
Chen XH,Lu LL,Ke HP,Liu ZC,Wang HF,Wei W,Qi YF,Wang HS,Cai SH,Du J
Mon May 01 00:00:00 UTC 2017
EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis.
Journal of cellular and molecular medicine
Yang Y,Chen XX,Li WX,Wu XQ,Huang C,Xie J,Zhao YX,Meng XM,Li J
Sun Oct 01 00:00:00 UTC 2017
Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors.
FEBS letters
Takayama Y,Wakabayashi T,Kushige H,Saito Y,Shibuya Y,Shibata S,Akamatsu W,Okano H,Kida YS
Wed Feb 01 00:00:00 UTC 2017
Overexpression of heparanase attenuated TGF-β-stimulated signaling in tumor cells.
FEBS open bio
Batool T,Fang J,Barash U,Moustakas A,Vlodavsky I,Li JP
Wed Mar 01 00:00:00 UTC 2017
The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells.
Cell death & disease
Moreno-Càceres J,Caballero-Díaz D,Nwosu ZC,Meyer C,López-Luque J,Malfettone A,Lastra R,Serrano T,Ramos E,Dooley S,Fabregat I
Thu Oct 12 00:00:00 UTC 2017
The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).
The Journal of biological chemistry
Sarmento OF,Svingen PA,Xiong Y,Sun Z,Bamidele AO,Mathison AJ,Smyrk TC,Nair AA,Gonzalez MM,Sagstetter MR,Baheti S,McGovern DP,Friton JJ,Papadakis KA,Gautam G,Xavier RJ,Urrutia RA,Faubion WA
Fri Jan 13 00:00:00 UTC 2017
IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.
Scientific reports
Wang S,Liu C,Sun Z,Yan P,Liang H,Huang K,Li C,Tian J
Fri Jun 23 00:00:00 UTC 2017
TGF-β signalling and PEG10 are mutually exclusive and inhibitory in chondrosarcoma cells.
Scientific reports
Shinohara N,Maeda S,Yahiro Y,Sakuma D,Matsuyama K,Imamura K,Kawamura I,Setoguchi T,Ishidou Y,Nagano S,Komiya S
Wed Oct 18 00:00:00 UTC 2017
Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling.
eLife
Wang Y,Zhang X,Huang H,Xia Y,Yao Y,Mak AF,Yung PS,Chan KM,Wang L,Zhang C,Huang Y,Mak KK
100-21 was used in Cell Culture to investigate the effects of Osteocalcin expression on tendon repair in mice.
Fri Dec 15 00:00:00 UTC 2017
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts.
Scientific reports
Smith ER,Tan SJ,Holt SG,Hewitson TD
100-21 was used in Cell Culture to demonstrate that FGF23 is produced by renal tubules in response to tubulointerstitial injury and induces fibrogeneisis in fibroblasts primed by injury. This might provide a novel therapeutic target in renal fibrosis.
Tue Jun 13 00:00:00 UTC 2017
Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees.
Scientific reports
Sluzalska KD,Liebisch G,Wilhelm J,Ishaque B,Hackstein H,Schmitz G,Rickert M,Steinmeyer J
Wed Oct 18 00:00:00 UTC 2017
Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration.
Scientific reports
Hachim IY,Villatoro M,Canaff L,Hachim MY,Boudreault J,Haiub H,Ali S,Lebrun JJ
Fri Nov 03 00:00:00 UTC 2017
ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer.
Scientific reports
Gharibi A,La Kim S,Molnar J,Brambilla D,Adamian Y,Hoover M,Hong J,Lin J,Wolfenden L,Kelber JA
Wed Aug 30 00:00:00 UTC 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
100-21 was used in Cell Culture to identify Foxo1 as a major transcription factor controlling the development of Th9 cells and other IL-9-producing T cells.
Mon Oct 09 00:00:00 UTC 2017
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Nature communications
Romagnani A,Vettore V,Rezzonico-Jost T,Hampe S,Rottoli E,Nadolni W,Perotti M,Meier MA,Hermanns C,Geiger S,Wennemuth G,Recordati C,Matsushita M,Muehlich S,Proietti M,Chubanov V,Gudermann T,Grassi F,Zierler S
Mon Dec 04 00:00:00 UTC 2017
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.
Nature communications
Deczkowska A,Matcovitch-Natan O,Tsitsou-Kampeli A,Ben-Hamo S,Dvir-Szternfeld R,Spinrad A,Singer O,David E,Winter DR,Smith LK,Kertser A,Baruch K,Rosenzweig N,Terem A,Prinz M,Villeda S,Citri A,Amit I,Schwartz M
Thu Sep 28 00:00:00 UTC 2017
Biological and mechanical characterization of chitosan-alginate scaffolds for growth factor delivery and chondrogenesis.
Journal of biomedical materials research. Part B, Applied biomaterials
Reed S,Wu BM
100-21 was used in In vitro experiments to explore the ability of Ch-Al chain functional groups to control and extend GF delivery and minimize GF burst release, using model proteins BSA and histone at high loading dose and chondrogenic protein TGF-β1 at low loading dose in complete media.
Wed Feb 01 00:00:00 UTC 2017
The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
The Journal of biological chemistry
Jansson AM,Csiszar A,Maier J,Nyström AC,Ax E,Johansson P,Schiavone LH
Fri Sep 15 00:00:00 UTC 2017
Suppression of Th17-polarized airway inflammation by rapamycin.
Scientific reports
Joean O,Hueber A,Feller F,Jirmo AC,Lochner M,Dittrich AM,Albrecht M
Fri Nov 10 00:00:00 UTC 2017
BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation.
Scientific reports
Schreiber I,Dörpholz G,Ott CE,Kragesteen B,Schanze N,Lee CT,Köhrle J,Mundlos S,Ruschke K,Knaus P
Fri Dec 08 00:00:00 UTC 2017
Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.
Nature communications
Kitano K,Schwartz DM,Zhou H,Gilpin SE,Wojtkiewicz GR,Ren X,Sommer CA,Capilla AV,Mathisen DJ,Goldstein AM,Mostoslavsky G,Ott HC
Tue Oct 10 00:00:00 UTC 2017
Differentiation of cardiomyocytes and generation of human engineered heart tissue.
Nature protocols
Breckwoldt K,Letuffe-Brenière D,Mannhardt I,Schulze T,Ulmer B,Werner T,Benzin A,Klampe B,Reinsch MC,Laufer S,Shibamiya A,Prondzynski M,Mearini G,Schade D,Fuchs S,Neuber C,Krämer E,Saleem U,Schulze ML,Rodriguez ML,Eschenhagen T,Hansen A
100-21 was used in In vitro experiments to establish a protocol that describes parallel expansion of hiPSCs; standardized generation of defined embryoid bodies, growth factor and small-molecule-based cardiac differentiation; and standardized generation of EHTs.
Thu Jun 01 00:00:00 UTC 2017
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
Nature communications
Dufton NP,Peghaire CR,Osuna-Almagro L,Raimondi C,Kalna V,Chauhan A,Webb G,Yang Y,Birdsey GM,Lalor P,Mason JC,Adams DH,Randi AM
Thu Oct 12 00:00:00 UTC 2017
Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway.
The Journal of biological chemistry
Tang LY,Heller M,Meng Z,Yu LR,Tang Y,Zhou M,Zhang YE
Fri Mar 10 00:00:00 UTC 2017
Cryopreservation of Human Mesenchymal Stem Cells in an Allogeneic Bioscaffold based on Platelet Rich Plasma and Synovial Fluid.
Scientific reports
Gurruchaga H,Saenz Del Burgo L,Garate A,Delgado D,Sanchez P,Orive G,Ciriza J,Sanchez M,Pedraz JL
Thu Nov 16 00:00:00 UTC 2017
Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.
Nature communications
Vallecillo-García P,Orgeur M,Vom Hofe-Schneider S,Stumm J,Kappert V,Ibrahim DM,Börno ST,Hayashi S,Relaix F,Hildebrandt K,Sengle G,Koch M,Timmermann B,Marazzi G,Sassoon DA,Duprez D,Stricker S
Tue Oct 31 00:00:00 UTC 2017
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.
Oncotarget
Preca BT,Bajdak K,Mock K,Lehmann W,Sundararajan V,Bronsert P,Matzge-Ogi A,Orian-Rousseau V,Brabletz S,Brabletz T,Maurer J,Stemmler MP
100-21 was used in In vitro experiments to find a novel autocrine mechanism how ZEB1 is accelerating EMT.
Tue Feb 14 00:00:00 UTC 2017
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.
Oncotarget
Preca BT,Bajdak K,Mock K,Lehmann W,Sundararajan V,Bronsert P,Matzge-Ogi A,Orian-Rousseau V,Brabletz S,Brabletz T,Maurer J,Stemmler MP
100-21 was used in In vitro experiments to find a novel autocrine mechanism how ZEB1 is accelerating EMT.
Tue Feb 14 00:00:00 UTC 2017
An integrated method for cell isolation and migration on a chip.
Scientific reports
Lv X,Geng Z,Fan Z,Wang S,Pei W,Chen H
Mon Aug 21 00:00:00 UTC 2017
An integrated method for cell isolation and migration on a chip.
Scientific reports
Lv X,Geng Z,Fan Z,Wang S,Pei W,Chen H
Mon Aug 21 00:00:00 UTC 2017
Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells.
Scientific reports
Fong LE,Sulistijo ES,Miller-Jensen K
Thu Nov 23 00:00:00 UTC 2017
Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation.
Scientific reports
Shentu TP,Huang TS,Cernelc-Kohan M,Chan J,Wong SS,Espinoza CR,Tan C,Gramaglia I,van der Heyde H,Chien S,Hagood JS
Fri Dec 22 00:00:00 UTC 2017
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
The Journal of biological chemistry
Chen J,Martindale JL,Cramer C,Gorospe M,Atasoy U,Drew PD,Yu S
Fri Sep 01 00:00:00 UTC 2017
Different culture conditions affect the growth of human tendon stem/progenitor cells (TSPCs) within a mixed tendon cells (TCs) population.
Journal of experimental orthopaedics
Viganò M,Perucca Orfei C,Colombini A,Stanco D,Randelli P,Sansone V,de Girolamo L
Fri Dec 01 00:00:00 UTC 2017
Increased tumor-infiltrating CD45RA-CCR7- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Cell death & disease
Mao FY,Kong H,Zhao YL,Peng LS,Chen W,Zhang JY,Cheng P,Wang TT,Lv YP,Teng YS,Fu XL,Liu YG,Wu XL,Hao CJ,You N,Luo P,Yu PW,Zou QM,Guo G,Zhuang Y
Thu Aug 17 00:00:00 UTC 2017
Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model.
Scientific reports
Karhadkar TR,Pilling D,Cox N,Gomer RH
Wed Nov 08 00:00:00 UTC 2017
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production.
Scientific reports
Polesso F,Sarker M,Anderson A,Parker DC,Murray SE
Tue Nov 07 00:00:00 UTC 2017
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Nature communications
Hinge A,Xu J,Javier J,Mose E,Kumar S,Kapur R,Srour EF,Malik P,Aronow BJ,Filippi MD
Wed Feb 08 00:00:00 UTC 2017
Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation.
Cell death & disease
Wang S,Li Y,Fan J,Zhang X,Luan J,Bian Q,Ding T,Wang Y,Wang Z,Song P,Cui D,Mei X,Ju D
Thu Jul 20 00:00:00 UTC 2017
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells.
Scientific reports
Wahlin KJ,Maruotti JA,Sripathi SR,Ball J,Angueyra JM,Kim C,Grebe R,Li W,Jones BW,Zack DJ
100-21 was used in Cell Culture to study an in vitro method for human pluripotent stem cells (hPSC) differentiation into 3D retinas with at least some important features reminiscent of mature retina, including exuberant outgrowth of outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and membrane conductances and synaptic vesicle release properties consistent with possible photoreceptor synaptic function.
Mon Apr 10 00:00:00 UTC 2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
Wed Mar 15 00:00:00 UTC 2017
Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.
Scientific reports
Chen J,Adamiak W,Huang G,Atasoy U,Rostami A,Yu S
Fri Dec 08 00:00:00 UTC 2017
MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor.
Immunity
Yang HY,Barbi J,Wu CY,Zheng Y,Vignali PD,Wu X,Tao JH,Park BV,Bandara S,Novack L,Ni X,Yang X,Chang KY,Wu RC,Zhang J,Yang CW,Pardoll DM,Li H,Pan F
Tue Jul 19 00:00:00 UTC 2016
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.
Immunity
Cortez VS,Cervantes-Barragan L,Robinette ML,Bando JK,Wang Y,Geiger TL,Gilfillan S,Fuchs A,Vivier E,Sun JC,Cella M,Colonna M
Tue May 17 00:00:00 UTC 2016
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Immunity
Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C
Tue Jun 21 00:00:00 UTC 2016
GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.
Blood
Artz A,Butz S,Vestweber D
Thu Jul 28 00:00:00 UTC 2016
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.
The Journal of clinical investigation
Cheng HY,Gaddis DE,Wu R,McSkimming C,Haynes LD,Taylor AM,McNamara CA,Sorci-Thomas M,Hedrick CC
Thu Sep 01 00:00:00 UTC 2016
miR-23∼27∼24 clusters control effector T cell differentiation and function.
The Journal of experimental medicine
Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF
Mon Feb 08 00:00:00 UTC 2016
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
The Journal of experimental medicine
Wang Y,Ma CS,Ling Y,Bousfiha A,Camcioglu Y,Jacquot S,Payne K,Crestani E,Roncagalli R,Belkadi A,Kerner G,Lorenzo L,Deswarte C,Chrabieh M,Patin E,Vincent QB,Müller-Fleckenstein I,Fleckenstein B,Ailal F,Quintana-Murci L,Fraitag S,Alyanakian MA,Leruez-Ville M,Picard C,Puel A,Bustamante J,Boisson-Dupuis S,Malissen M,Malissen B,Abel L,Hovnanian A,Notarangelo LD,Jouanguy E,Tangye SG,Béziat V,Casanova JL
Mon Oct 17 00:00:00 UTC 2016
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
The Journal of experimental medicine
Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C
Mon Aug 22 00:00:00 UTC 2016
Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.
The Journal of experimental medicine
Chopra M,Biehl M,Steinfatt T,Brandl A,Kums J,Amich J,Vaeth M,Kuen J,Holtappels R,Podlech J,Mottok A,Kraus S,Jordán-Garrote AL,Bäuerlein CA,Brede C,Ribechini E,Fick A,Seher A,Polz J,Ottmüller KJ,Baker J,Nishikii H,Ritz M,Mattenheimer K,Schwinn S,Winter T,Schäfer V,Krappmann S,Einsele H,Müller TD,Reddehase MJ,Lutz MB,Männel DN,Berberich-Siebelt F,Wajant H,Beilhack A
Mon Aug 22 00:00:00 UTC 2016
Control of Foxp3 stability through modulation of TET activity.
The Journal of experimental medicine
Yue X,Trifari S,Äijö T,Tsagaratou A,Pastor WA,Zepeda-Martínez JA,Lio CW,Li X,Huang Y,Vijayanand P,Lähdesmäki H,Rao A
Mon Mar 07 00:00:00 UTC 2016
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
The Journal of experimental medicine
Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG
Mon Jul 25 00:00:00 UTC 2016
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation.
Cancer research
Wang Y,Hsu JM,Kang Y,Wei Y,Lee PC,Chang SJ,Hsu YH,Hsu JL,Wang HL,Chang WC,Li CW,Liao HW,Chang SS,Xia W,Ko HW,Chou CK,Fleming JB,Wang H,Hwang RF,Chen Y,Qin J,Hung MC
100-21 was used in In vitro experiments to investigate Gli1 regulation in pancreatic ductal carcinoma.
Thu Dec 01 00:00:00 UTC 2016
The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia.
Leukemia
Rouce RH,Shaim H,Sekine T,Weber G,Ballard B,Ku S,Barese C,Murali V,Wu MF,Liu H,Shpall EJ,Bollard CM,Rabin KR,Rezvani K
100-21 was used in Sample Preparation (FC/FACS) to indicate that by regulating the TGF-β/SMAD pathway, ALL blasts induce changes in NK cells to evade innate immune surveillance, thus highlighting the importance of developing novel therapies to target this inhibitory pathway and restore antileukemic cytotoxicity.
Fri Apr 01 00:00:00 UTC 2016
Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.
Proceedings of the National Academy of Sciences of the United States of America
Gjaltema RA,van der Stoel MM,Boersema M,Bank RA
Tue Jun 28 00:00:00 UTC 2016
Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America
Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC
Tue Aug 16 00:00:00 UTC 2016
Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Woo JS,Srikanth S,Nishi M,Ping P,Takeshima H,Gwack Y
Tue Mar 08 00:00:00 UTC 2016
Mitochondrial biogenesis is required for axonal growth.
Development (Cambridge, England)
Vaarmann A,Mandel M,Zeb A,Wareski P,Liiv J,Kuum M,Antsov E,Liiv M,Cagalinec M,Choubey V,Kaasik A
100-21 was used in Sample Preparation (Western Blotting) to determine the role of mitochondrial biogenesis and ATP production in neuronal growth.
Wed Jun 01 00:00:00 UTC 2016
Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells.
Oncogenesis
Zhang X,Liu X,Luo J,Xiao W,Ye X,Chen M,Li Y,Zhang GJ
Mon Nov 14 00:00:00 UTC 2016
Novel 3-D cell culture system for in vitro evaluation of anticancer drugs under anchorage-independent conditions.
Cancer science
Aihara A,Abe N,Saruhashi K,Kanaki T,Nishino T
Thu Dec 01 00:00:00 UTC 2016
Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms.
mAbs
Bedinger D,Lao L,Khan S,Lee S,Takeuchi T,Mirza AM
100-21 was used in Surface Plasmon Resonance to study the number of antibodies that bind and neutralize various combinations of TGFβ1, 2 or 3 using fully human antibody phage display libraries.
Tue Dec 13 00:00:00 UTC 2016
TGF-β1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells toward Nucleus Pulposus-like Cells.
Stem cells (Dayton, Ohio)
Colombier P,Clouet J,Boyer C,Ruel M,Bonin G,Lesoeur J,Moreau A,Fellah BH,Weiss P,Lescaudron L,Camus A,Guicheux J
Tue Mar 01 00:00:00 UTC 2016
Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis.
Stem cells (Dayton, Ohio)
Abbonante V,Di Buduo CA,Gruppi C,Malara A,Gianelli U,Celesti G,Anselmo A,Laghi L,Vercellino M,Visai L,Iurlo A,Moratti R,Barosi G,Rosti V,Balduini A
Fri Apr 01 00:00:00 UTC 2016
Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition.
Journal of immunology (Baltimore, Md. : 1950)
Picarda G,Chéneau C,Humbert JM,Bériou G,Pilet P,Martin J,Duteille F,Perrot P,Bellier-Waast F,Heslan M,Haspot F,Guillon F,Josien R,Halary FA
Sun May 01 00:00:00 UTC 2016
Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
Journal of immunology (Baltimore, Md. : 1950)
Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V
Thu Dec 01 00:00:00 UTC 2016
A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen LC,Nicholson YT,Rosborough BR,Thomson AW,Raimondi G
Mon Aug 15 00:00:00 UTC 2016
The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Choi SC,Hutchinson TE,Titov AA,Seay HR,Li S,Brusko TM,Croker BP,Salek-Ardakani S,Morel L
Fri Jul 15 00:00:00 UTC 2016
Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Speth JM,Bourdonnay E,Penke LR,Mancuso P,Moore BB,Weinberg JB,Peters-Golden M
Wed Jun 15 00:00:00 UTC 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
Fri Jul 15 00:00:00 UTC 2016
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.
Journal of immunology (Baltimore, Md. : 1950)
Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V
Sun May 01 00:00:00 UTC 2016
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V
Sat Oct 01 00:00:00 UTC 2016
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V
Sat Oct 01 00:00:00 UTC 2016
Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner.
Journal of immunology (Baltimore, Md. : 1950)
Sasidharan Nair V,Song MH,Oh KI
Tue Mar 01 00:00:00 UTC 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 UTC 2016
Cutting Edge: ACVRL1 Signaling Augments CD8α+ Dendritic Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Verma R,Jaiswal H,Chauhan KS,Kaushik M,Tailor P
Mon Aug 15 00:00:00 UTC 2016
Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E
Fri Apr 01 00:00:00 UTC 2016
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Kaufmann U,Shaw PJ,Kozhaya L,Subramanian R,Gaida K,Unutmaz D,McBride HJ,Feske S
Fri Jan 15 00:00:00 UTC 2016
ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Panoutsakopoulou V
Wed Jun 15 00:00:00 UTC 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
Fri Apr 01 00:00:00 UTC 2016
Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Brucklacher-Waldert V,Ferreira C,Innocentin S,Kamdar S,Withers DR,Kullberg MC,Veldhoen M
Wed Jun 15 00:00:00 UTC 2016
The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis.
Cell and tissue research
Mia MM,Bank RA
100-21 was used in Cell Culture to conclude that major discrepancies were seen between mRNA levels of collagen type I and cells stained positive for collagen, underlining the need for protein data in fibrosis studies to make reliable conclusions.
Tue Mar 01 00:00:00 UTC 2016
Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3.
Cell biochemistry and function
Liang C,Bu S,Fan X
Fri Jul 01 00:00:00 UTC 2016
Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.
AIDS research and human retroviruses
Martins LJ,Bonczkowski P,Spivak AM,De Spiegelaere W,Novis CL,DePaula-Silva AB,Malatinkova E,Trypsteen W,Bosque A,Vanderkerckhove L,Planelles V
100-21 was used in Cell Culture to propose a model that utilizes cultured central memory CD4(+) T cells and replication-competent HIV-1, to generate latently infected cells that can be reactivated using latency reversing agents in the presence of antiretroviral drugs.
Mon Feb 01 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
Thu Mar 03 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
Thu Mar 03 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
Thu Mar 03 00:00:00 UTC 2016
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
Scientific reports
Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C
Thu Mar 24 00:00:00 UTC 2016
Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
The Journal of pathology
Cheng CM,Shiah SG,Huang CC,Hsiao JR,Chang JY
100-21 was used in Cell Culture to reveal that miR-455-5p expression is regulated by the TGF-β-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis.
Thu Sep 01 00:00:00 UTC 2016
The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake.
Scientific reports
Salter RC,Foka P,Davies TS,Gallagher H,Michael DR,Ashlin TG,Ramji DP
Fri Sep 30 00:00:00 UTC 2016
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
Nature communications
Yahara Y,Takemori H,Okada M,Kosai A,Yamashita A,Kobayashi T,Fujita K,Itoh Y,Nakamura M,Fuchino H,Kawahara N,Fukui N,Watanabe A,Kimura T,Tsumaki N
Thu Mar 24 00:00:00 UTC 2016
Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis.
Scientific reports
Lim JY,Im KI,Lee ES,Kim N,Nam YS,Jeon YW,Cho SG
Wed Jun 01 00:00:00 UTC 2016
Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways.
Nature communications
Ma B,Cheng H,Gao R,Mu C,Chen L,Wu S,Chen Q,Zhu Y
Thu Mar 31 00:00:00 UTC 2016
Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus.
Scientific reports
Garcia J,Wright K,Roberts S,Kuiper JH,Mangham C,Richardson J,Mennan C
Wed Apr 13 00:00:00 UTC 2016
LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling.
Scientific reports
Niu Y,Shao Z,Wang H,Yang J,Zhang F,Luo Y,Xu L,Ding Y,Zhao L
Mon May 16 00:00:00 UTC 2016
Galunisertib inhibits glioma vasculogenic mimicry formation induced by astrocytes.
Scientific reports
Zhang C,Chen W,Zhang X,Huang B,Chen A,He Y,Wang J,Li X
Tue Mar 15 00:00:00 UTC 2016
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
Nature communications
Chou TF,Chuang YT,Hsieh WC,Chang PY,Liu HY,Mo ST,Hsu TS,Miaw SC,Chen RH,Kimchi A,Lai MZ
Fri Jun 17 00:00:00 UTC 2016
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Nature communications
Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S
Fri Aug 05 00:00:00 UTC 2016
Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators.
Scientific reports
Wei S,Zou Q,Lai S,Zhang Q,Li L,Yan Q,Zhou X,Zhong H,Lai L
Tue Jan 19 00:00:00 UTC 2016
Metformin is a novel suppressor for transforming growth factor (TGF)-β1.
Scientific reports
Xiao H,Zhang J,Xu Z,Feng Y,Zhang M,Liu J,Chen R,Shen J,Wu J,Lu Z,Fang X,Li J,Zhang Y
Tue Jun 28 00:00:00 UTC 2016
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells.
Stem cell reports
Månsson-Broberg A,Rodin S,Bulatovic I,Ibarra C,Löfling M,Genead R,Wärdell E,Felldin U,Granath C,Alici E,Le Blanc K,Smith CIE,Salašová A,Westgren M,Sundström E,Uhlén P,Arenas E,Sylvén C,Tryggvason K,Corbascio M,Simonson OE,Österholm C,Grinnemo KH
Tue Apr 12 00:00:00 UTC 2016
Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.
Molecular & cellular proteomics : MCP
Blokzijl A,Zieba A,Hust M,Schirrmann T,Helmsing S,Grannas K,Hertz E,Moren A,Chen L,Söderberg O,Moustakas A,Dübel S,Landegren U
Wed Jun 01 00:00:00 UTC 2016
JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation.
The Journal of biological chemistry
Millena AC,Vo BT,Khan SA
Fri Aug 19 00:00:00 UTC 2016
Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox.
Oncotarget
Li Q,Wang Y,Xiao H,Li Y,Kan X,Wang X,Zhang G,Wang Z,Yang Q,Chen X,Weng X,Chen Y,Zhou B,Guo Y,Liu X,Zhu X
100-21 was used in In vitro experiments to provide a promising candidate for metastatic intervention.
Tue Jul 26 00:00:00 UTC 2016
Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox.
Oncotarget
Li Q,Wang Y,Xiao H,Li Y,Kan X,Wang X,Zhang G,Wang Z,Yang Q,Chen X,Weng X,Chen Y,Zhou B,Guo Y,Liu X,Zhu X
100-21 was used in In vitro experiments to provide a promising candidate for metastatic intervention.
Tue Jul 26 00:00:00 UTC 2016
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
The Journal of biological chemistry
Watanabe Y,Papoutsoglou P,Maturi V,Tsubakihara Y,Hottiger MO,Heldin CH,Moustakas A
Fri Jun 10 00:00:00 UTC 2016
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials.
Scientific reports
Jeon OH,Panicker LM,Lu Q,Chae JJ,Feldman RA,Elisseeff JH
Thu May 26 00:00:00 UTC 2016
MiR-185/AKT and miR-29a/collagen 1a pathways are activated in IPF BAL cells.
Oncotarget
Tsitoura E,Wells AU,Karagiannis K,Lasithiotaki I,Vasarmidi E,Bibaki E,Koutoulaki C,Sato H,Spandidos DA,Siafakas NM,Sourvinos G,Antoniou KM
100-21 was used in Cell Culture to investigate microRNAs associated with fibrosis.
Tue Nov 15 00:00:00 UTC 2016
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.
Nature communications
Cammareri P,Rose AM,Vincent DF,Wang J,Nagano A,Libertini S,Ridgway RA,Athineos D,Coates PJ,McHugh A,Pourreyron C,Dayal JH,Larsson J,Weidlich S,Spender LC,Sapkota GP,Purdie KJ,Proby CM,Harwood CA,Leigh IM,Clevers H,Barker N,Karlsson S,Pritchard C,Marais R,Chelala C,South AP,Sansom OJ,Inman GJ
Thu Aug 25 00:00:00 UTC 2016
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.
The Journal of biological chemistry
Prior KK,Wittig I,Leisegang MS,Groenendyk J,Weissmann N,Michalak M,Jansen-Dürr P,Shah AM,Brandes RP
Fri Mar 25 00:00:00 UTC 2016
Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis.
Scientific reports
Zhou W,Mo X,Cui W,Zhang Z,Li D,Li L,Xu L,Yao H,Gao J
100-21 was used in Cell Culture to study whether nuclear factor erythroid 2 related factor 2 (Nrf2) regulates snail thereby modulating the development of pulmonary fibrosis (PF).
Fri Dec 16 00:00:00 UTC 2016
Visualizing tropoelastin in a long-term human elastic fibre cell culture model.
Scientific reports
Halm M,Schenke-Layland K,Jaspers S,Wenck H,Fischer F
Thu Feb 04 00:00:00 UTC 2016
Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.
Molecular therapy. Methods & clinical development
Sakurai F,Narii N,Tomita K,Togo S,Takahashi K,Machitani M,Tachibana M,Ouchi M,Katagiri N,Urata Y,Fujiwara T,Mizuguchi H
Fri Mar 11 00:00:00 UTC 2016
LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia.
Scientific reports
He Y,Ou Z,Chen X,Zu X,Liu L,Li Y,Cao Z,Chen M,Chen Z,Chen H,Qi L,Wang L
Tue May 31 00:00:00 UTC 2016
Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar.
Scientific reports
Su L,Li X,Wu X,Hui B,Han S,Gao J,Li Y,Shi J,Zhu H,Zhao B,Hu D
Mon May 16 00:00:00 UTC 2016
Tenascin-C drives persistence of organ fibrosis.
Nature communications
Bhattacharyya S,Wang W,Morales-Nebreda L,Feng G,Wu M,Zhou X,Lafyatis R,Lee J,Hinchcliff M,Feghali-Bostwick C,Lakota K,Budinger GR,Raparia K,Tamaki Z,Varga J
Fri Jun 03 00:00:00 UTC 2016
Tunable Microfibers Suppress Fibrotic Encapsulation via Inhibition of TGFβ Signaling.
Tissue engineering. Part A
Allen J,Ryu J,Maggi A,Flores B,Greer JR,Desai T
100-21 was used in Cell Culture to demonstrate a simple and powerful strategy to improve surface biocompatibility and reduce fibrotic encapsulation around implanted materials.
Fri Jan 01 00:00:00 UTC 2016
Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation.
Scientific reports
Shen C,Jiang L,Shao H,You C,Zhang G,Ding S,Bian T,Han C,Meng Q
Wed Nov 30 00:00:00 UTC 2016
TGF-β1 Induces Polypyrimidine Tract-Binding Protein to Alter Fibroblasts Proliferation and Fibronectin Deposition in Keloid.
Scientific reports
Jiao H,Dong P,Yan L,Yang Z,Lv X,Li Q,Zong X,Fan J,Fu X,Liu X,Xiao R
Tue Nov 29 00:00:00 UTC 2016
Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1.
Scientific reports
Ge J,Chang N,Zhao Z,Tian L,Duan X,Yang L,Li L
Thu Feb 25 00:00:00 UTC 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
Tue May 17 00:00:00 UTC 2016
Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling.
Oncotarget
Guo YH,Wang LQ,Li B,Xu H,Yang JH,Zheng LS,Yu P,Zhou AD,Zhang Y,Xie SJ,Liang ZR,Zhang CM,Zhou H,Qu LH
100-21 was used in Cell Culture to indicate that miR-150 is a novel Wnt effector that may significantly enhance EMT of CRC cells by targeting the CREB signaling pathway.
Tue Jul 05 00:00:00 UTC 2016
Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions.
Scientific reports
Leijten J,Teixeira LS,Bolander J,Ji W,Vanspauwen B,Lammertyn J,Schrooten J,Luyten FP
Thu Nov 03 00:00:00 UTC 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
Fri Aug 05 00:00:00 UTC 2016
Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy.
Scientific reports
Deng Y,Guo Y,Liu P,Zeng R,Ning Y,Pei G,Li Y,Chen M,Guo S,Li X,Han M,Xu G
Mon Jan 25 00:00:00 UTC 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Fri Jun 03 00:00:00 UTC 2016
Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop.
Scientific reports
Kechagia JZ,Ezra DG,Burton MJ,Bailly M
Mon Jun 20 00:00:00 UTC 2016
Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.
Scientific reports
Lee H,Nam D,Choi JK,Araúzo-Bravo MJ,Kwon SY,Zaehres H,Lee T,Park CY,Kang HW,Schöler HR,Kim JB
Fri Feb 05 00:00:00 UTC 2016
Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties.
Molecular & cellular proteomics : MCP
Narushima Y,Kozuka-Hata H,Koyama-Nasu R,Tsumoto K,Inoue J,Akiyama T,Oyama M
Tue Mar 01 00:00:00 UTC 2016
ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.
Nature communications
Lehmann W,Mossmann D,Kleemann J,Mock K,Meisinger C,Brummer T,Herr R,Brabletz S,Stemmler MP,Brabletz T
Mon Feb 15 00:00:00 UTC 2016
Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma.
Scientific reports
Takai A,Fako V,Dang H,Forgues M,Yu Z,Budhu A,Wang XW
Tue Feb 16 00:00:00 UTC 2016
Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma.
Scientific reports
Takai A,Fako V,Dang H,Forgues M,Yu Z,Budhu A,Wang XW
Tue Feb 16 00:00:00 UTC 2016
Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma.
Scientific reports
Takai A,Fako V,Dang H,Forgues M,Yu Z,Budhu A,Wang XW
Tue Feb 16 00:00:00 UTC 2016
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Nature communications
Hashimoto S,Mikami S,Sugino H,Yoshikawa A,Hashimoto A,Onodera Y,Furukawa S,Handa H,Oikawa T,Okada Y,Oya M,Sabe H
Mon Feb 08 00:00:00 UTC 2016
Suberoylanilide hydroxamic acid attenuates paraquat-induced pulmonary fibrosis by preventing Smad7 from deacetylation in rats.
Journal of thoracic disease
Rao SS,Zhang XY,Shi MJ,Xiao Y,Zhang YY,Wang YY,Zhang CZ,Shao SJ,Liu XM,Guo B
100-21 was used in Cell Culture to investigate the molecular mechanism of SAHA in attenuating pulmonary fibrosis by regulating stability of Smad7 in paraquat (PQ)-induced lung fibrosis animal model and cultured pulmonary fibroblasts.
Thu Sep 01 00:00:00 UTC 2016
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
Tue Dec 15 00:00:00 UTC 2015
α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.
Blood
Uryu H,Hashimoto D,Kato K,Hayase E,Matsuoka S,Ogasawara R,Takahashi S,Maeda Y,Iwasaki H,Miyamoto T,Saijo S,Iwakura Y,Hill GR,Akashi K,Teshima T
Thu May 07 00:00:00 UTC 2015
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
The Journal of clinical investigation
Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M
Tue Dec 01 00:00:00 UTC 2015
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.
The Journal of clinical investigation
Desvignes L,Weidinger C,Shaw P,Vaeth M,Ribierre T,Liu M,Fergus T,Kozhaya L,McVoy L,Unutmaz D,Ernst JD,Feske S
Mon Jun 01 00:00:00 UTC 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
Mon May 04 00:00:00 UTC 2015
STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
The Journal of experimental medicine
Wilson RP,Ives ML,Rao G,Lau A,Payne K,Kobayashi M,Arkwright PD,Peake J,Wong M,Adelstein S,Smart JM,French MA,Fulcher DA,Picard C,Bustamante J,Boisson-Dupuis S,Gray P,Stepensky P,Warnatz K,Freeman AF,Rossjohn J,McCluskey J,Holland SM,Casanova JL,Uzel G,Ma CS,Tangye SG,Deenick EK
Mon Jun 01 00:00:00 UTC 2015
The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
The Journal of experimental medicine
Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG
Mon Jun 29 00:00:00 UTC 2015
Bee venom processes human skin lipids for presentation by CD1a.
The Journal of experimental medicine
Bourgeois EA,Subramaniam S,Cheng TY,De Jong A,Layre E,Ly D,Salimi M,Legaspi A,Modlin RL,Salio M,Cerundolo V,Moody DB,Ogg G
Mon Feb 09 00:00:00 UTC 2015
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis.
Autophagy
Grootaert MO,da Costa Martins PA,Bitsch N,Pintelon I,De Meyer GR,Martinet W,Schrijvers DM
100-21 was used in In vitro experiments to study the effect of defective autophagy on vascular smooth muscle cell survival and phenotype.
Mon Nov 02 00:00:00 UTC 2015
Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.
Proceedings of the National Academy of Sciences of the United States of America
Yan D,Farache J,Mingueneau M,Mathis D,Benoist C
Tue Dec 01 00:00:00 UTC 2015
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.
Proceedings of the National Academy of Sciences of the United States of America
Fiebiger BM,Maamary J,Pincetic A,Ravetch JV
Tue May 05 00:00:00 UTC 2015
miR-30e* is an independent subtype-specific prognostic marker in breast cancer.
British journal of cancer
D'Aiuto F,Callari M,Dugo M,Merlino G,Musella V,Miodini P,Paolini B,Cappelletti V,Daidone MG
Tue Jul 14 00:00:00 UTC 2015
HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition.
International journal of cancer
Ranieri D,Belleudi F,Magenta A,Torrisi MR
Wed Jul 01 00:00:00 UTC 2015
A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.
International journal of cancer
Preca BT,Bajdak K,Mock K,Sundararajan V,Pfannstiel J,Maurer J,Wellner U,Hopt UT,Brummer T,Brabletz S,Brabletz T,Stemmler MP
100-21 was used in Cell Culture to study the direct link between SEB1, CD44 and tumourigenesis in epithelial-mesenchymal transition (EMT) to identify a self-enforcing feedback loop that employs CD44s to activate ZEB1 expression which renders tumor cell stemness independent of external stimuli, as ZEB1 downregulates ESRP1, further promoting CD44s isoform synthesis.
Tue Dec 01 00:00:00 UTC 2015
Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.
Immunology
Fossati-Jimack L,Ling GS,Baudino L,Szajna M,Manivannan K,Zhao JC,Midgley R,Chai JG,Simpson E,Botto M,Scott D
Thu Jan 01 00:00:00 UTC 2015
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.
European journal of immunology
Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S
Fri May 01 00:00:00 UTC 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
Wed Apr 01 00:00:00 UTC 2015
Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Cancer science
Feng XX,Luo J,Liu M,Yan W,Zhou ZZ,Xia YJ,Tu W,Li PY,Feng ZH,Tian DA
Fri May 01 00:00:00 UTC 2015
TGF-β1, GDF-5, and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow-derived stromal cells.
Stem cells (Dayton, Ohio)
Murphy MK,Huey DJ,Hu JC,Athanasiou KA
Sun Mar 01 00:00:00 UTC 2015
Molecular signature of erythroblast enucleation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H
Sat Aug 01 00:00:00 UTC 2015
Human myocardial pericytes: multipotent mesodermal precursors exhibiting cardiac specificity.
Stem cells (Dayton, Ohio)
Chen WC,Baily JE,Corselli M,Díaz ME,Sun B,Xiang G,Gray GA,Huard J,Péault B
Sun Feb 01 00:00:00 UTC 2015
In Vivo Identification and Induction of Articular Cartilage Stem Cells by Inhibiting NF-κB Signaling in Osteoarthritis.
Stem cells (Dayton, Ohio)
Tong W,Geng Y,Huang Y,Shi Y,Xiang S,Zhang N,Qin L,Shi Q,Chen Q,Dai K,Zhang X
Thu Oct 01 00:00:00 UTC 2015
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sun Q,Liu L,Roth M,Tian J,He Q,Zhong B,Bao R,Lan X,Jiang C,Sun J,Yang X,Lu S
Wed Jul 01 00:00:00 UTC 2015
IL2RA genetic variants reduce IL-2-dependent responses and aggravate human cutaneous leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Oliveira PR,Dessein H,Romano A,Cabantous S,de Brito ME,Santoro F,Pitta MG,Pereira V,Pontes-de-Carvalho LC,Rodrigues V,Rafati S,Argiro L,Dessein AJ
Sun Mar 15 00:00:00 UTC 2015
IL-7 Abrogates the Immunosuppressive Function of Human Double-Negative T Cells by Activating Akt/mTOR Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Allgäuer A,Schreiner E,Ferrazzi F,Ekici AB,Gerbitz A,Mackensen A,Völkl S
Thu Oct 01 00:00:00 UTC 2015
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
Journal of immunology (Baltimore, Md. : 1950)
Hsu P,Santner-Nanan B,Hu M,Skarratt K,Lee CH,Stormon M,Wong M,Fuller SJ,Nanan R
Thu Oct 15 00:00:00 UTC 2015
TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.
Journal of immunology (Baltimore, Md. : 1950)
Nurgazieva D,Mickley A,Moganti K,Ming W,Ovsyi I,Popova A,Awad K,Wang N,Bieback K,Goerdt S,Kzhyshkowska J,Gratchev A
Thu Jan 15 00:00:00 UTC 2015
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB
Tue Dec 15 00:00:00 UTC 2015
DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maruhashi T,Kaifu T,Yabe R,Seno A,Chung SH,Fujikado N,Iwakura Y
Mon Jun 15 00:00:00 UTC 2015
Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.
Journal of immunology (Baltimore, Md. : 1950)
Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH
Thu Oct 15 00:00:00 UTC 2015
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Brodeur TY,Robidoux TE,Weinstein JS,Craft J,Swain SL,Marshak-Rothstein A
Tue Dec 01 00:00:00 UTC 2015
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP
Sun Feb 01 00:00:00 UTC 2015
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Journal of immunology (Baltimore, Md. : 1950)
Rossetti M,Spreafico R,Saidin S,Chua C,Moshref M,Leong JY,Tan YK,Thumboo J,van Loosdregt J,Albani S
Thu Jan 01 00:00:00 UTC 2015
Differential TGF-β Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Levy N,Milikovsky DZ,Baranauskas G,Vinogradov E,David Y,Ketzef M,Abutbul S,Weissberg I,Kamintsky L,Fleidervish I,Friedman A,Monsonego A
Sat Aug 15 00:00:00 UTC 2015
The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis.
Journal of cellular and molecular medicine
Mia MM,Bank RA
Tue Dec 01 00:00:00 UTC 2015
Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum.
Scientific reports
Xie YJ,Zhou L,Jiang N,Zhang N,Zou N,Zhou L,Wang Y,Cowell JK,Shen Y
Fri Jan 16 00:00:00 UTC 2015
Fabrication of a myocardial patch with cells differentiated from human-induced pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.)
Ye L,Basu J,Zhang J
100-21 was used in In vitro experiments to provide a simple but effective method that can be used to combine hiPSC-ECs and hiPSC-CMs with hiPSC-derived smooth muscle cells to engineer a contracting patch of cardiac cells.
Wed Dec 23 00:00:00 UTC 2015
Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.
Cell death & disease
Grassi G,Di Caprio G,Santangelo L,Fimia GM,Cozzolino AM,Komatsu M,Ippolito G,Tripodi M,Alonzi T
Thu Sep 10 00:00:00 UTC 2015
Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.
The Journal of biological chemistry
Ji L,Xu J,Liu J,Amjad A,Zhang K,Liu Q,Zhou L,Xiao J,Li X
Fri May 01 00:00:00 UTC 2015
Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation.
Journal of visualized experiments : JoVE
Sharma A,Li G,Rajarajan K,Hamaguchi R,Burridge PW,Wu SM
100-21 was used in Cell Culture to conclude that these highly purified cardiomyocytes should enhance the reliability of results from human iPSC-based in vitro disease modeling studies and drug screening assays.
Wed Mar 18 00:00:00 UTC 2015
Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor β-1 Activation Mechanism.
The Journal of biological chemistry
Gjaltema RAF,de Rond S,Rots MG,Bank RA
Fri Nov 20 00:00:00 UTC 2015
Batf is important for IL-4 expression in T follicular helper cells.
Nature communications
Sahoo A,Alekseev A,Tanaka K,Obertas L,Lerman B,Haymaker C,Clise-Dwyer K,McMurray JS,Nurieva R
Mon Aug 17 00:00:00 UTC 2015
Real-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodies.
Scientific reports
Maier J,Traenkle B,Rothbauer U
Fri Aug 21 00:00:00 UTC 2015
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Nature communications
Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E
Mon Oct 05 00:00:00 UTC 2015
A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.
Molecular systems biology
Shields BB,Pecot CV,Gao H,McMillan E,Potts M,Nagel C,Purinton S,Wang Y,Ivan C,Kim HS,Borkowski RJ,Khan S,Rodriguez-Aguayo C,Lopez-Berestein G,Lea J,Gazdar A,Baggerly KA,Sood AK,White MA
100-21 was used in Cell Culture to investigate whether restoration of miRNA activity represents a common vulnerability among diverse epithelial ovarian cancer oncogenotypes.
Fri Dec 11 00:00:00 UTC 2015
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.
Scientific reports
Guo A,He D,Xu HB,Geng CA,Zhao J
Tue Sep 15 00:00:00 UTC 2015
Galangin attenuates airway remodelling by inhibiting TGF-β1-mediated ROS generation and MAPK/Akt phosphorylation in asthma.
Scientific reports
Liu YN,Zha WJ,Ma Y,Chen FF,Zhu W,Ge A,Zeng XN,Huang M
Thu Jul 09 00:00:00 UTC 2015
IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer.
Cell death & disease
Zhu S,Zhang J,Xu F,Xu E,Ruan W,Ma Y,Huang Q,Lai M
Thu Mar 19 00:00:00 UTC 2015
Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells.
Scientific reports
Liu T,Ren J,Wang W,Wei XW,Shen GB,Liu YT,Luo M,Xu GC,Shao B,Deng SY,He ZY,Liang X,Liu Y,Wen YZ,Xiang R,Yang L,Deng HX,Wei YQ
Fri Nov 13 00:00:00 UTC 2015
Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells.
The Journal of biological chemistry
Kawasaki K,Ushioda R,Ito S,Ikeda K,Masago Y,Nagata K
Fri Feb 06 00:00:00 UTC 2015
TGF-ß isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity.
Oncotarget
Riemenschneider MJ,Hirblinger M,Vollmann-Zwerenz A,Hau P,Proescholdt MA,Jaschinski F,Rothhammer-Hampl T,Wosikowski K,Janicot M,Leo E
100-21 was used in Sample Preparation (Western Blotting) to investigate the main TGF-ß signalling pathway across 13 different tumour types.
Tue Sep 29 00:00:00 UTC 2015
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells.
eLife
Reeder JE,Kwak YT,McNamara RP,Forst CV,D'Orso I
100-21 was used in In vitro experiments to investigate target genes and molecular mechanisms by which Tat modulates transcription.
Wed Oct 21 00:00:00 UTC 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 UTC 2015
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts.
Nature communications
Albrengues J,Bertero T,Grasset E,Bonan S,Maiel M,Bourget I,Philippe C,Herraiz Serrano C,Benamar S,Croce O,Sanz-Moreno V,Meneguzzi G,Feral CC,Cristofari G,Gaggioli C
Tue Dec 15 00:00:00 UTC 2015
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Nature communications
Yoon JH,Sudo K,Kuroda M,Kato M,Lee IK,Han JS,Nakae S,Imamura T,Kim J,Ju JH,Kim DK,Matsuzaki K,Weinstein M,Matsumoto I,Sumida T,Mamura M
Tue Jul 21 00:00:00 UTC 2015
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Nature communications
Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS
Fri Apr 24 00:00:00 UTC 2015
Novel regulation of Ski protein stability and endosomal sorting by actin cytoskeleton dynamics in hepatocytes.
The Journal of biological chemistry
Vázquez-Victorio G,Caligaris C,Del Valle-Espinosa E,Sosa-Garrocho M,González-Arenas NR,Reyes-Cruz G,Briones-Orta MA,Macías-Silva M
Fri Feb 13 00:00:00 UTC 2015
Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer.
Cell death & disease
Liang SQ,Marti TM,Dorn P,Froment L,Hall SR,Berezowska S,Kocher G,Schmid RA,Peng RW
Thu Jul 16 00:00:00 UTC 2015
Activation of Notch1 signalling promotes multi-lineage differentiation of c-Kit(POS)/NKX2.5(POS) bone marrow stem cells: implication in stem cell translational medicine.
Stem cell research & therapy
Ding R,Jiang X,Ha Y,Wang Z,Guo J,Jiang H,Zheng S,Shen Z,Jie W
100-21 was used in In vitro experiments to investigate if bone marrow mesenchymal cells can acquire cardiac stem cell characteristics through Nothc signalling and thus act as a feasible treatment option for injured hearts.
Sat May 09 00:00:00 UTC 2015
Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.
The Journal of biological chemistry
Courivaud T,Ferrand N,Elkhattouti A,Kumar S,Levy L,Ferrigno O,Atfi A,Prunier C
Fri Aug 21 00:00:00 UTC 2015
Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.
Current protocols in human genetics
Burridge PW,Holmström A,Wu JC
Tue Oct 06 00:00:00 UTC 2015
Statin treatment rescues FGFR3 skeletal dysplasia phenotypes.
Nature
Yamashita A,Morioka M,Kishi H,Kimura T,Yahara Y,Okada M,Fujita K,Sawai H,Ikegawa S,Tsumaki N
Thu Sep 25 00:00:00 UTC 2014
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Immunity
Shouval DS,Biswas A,Goettel JA,McCann K,Conaway E,Redhu NS,Mascanfroni ID,Al Adham Z,Lavoie S,Ibourk M,Nguyen DD,Samsom JN,Escher JC,Somech R,Weiss B,Beier R,Conklin LS,Ebens CL,Santos FG,Ferreira AR,Sherlock M,Bhan AK,Müller W,Mora JR,Quintana FJ,Klein C,Muise AM,Horwitz BH,Snapper SB
Thu May 15 00:00:00 UTC 2014
Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation.
Immunity
Hong C,Luckey MA,Ligons DL,Waickman AT,Park JY,Kim GY,Keller HR,Etzensperger R,Tai X,Lazarevic V,Feigenbaum L,Catalfamo M,Walsh ST,Park JH
Thu Jun 19 00:00:00 UTC 2014
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 UTC 2014
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Cancer cell
Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E
Mon May 12 00:00:00 UTC 2014
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
EMBO molecular medicine
Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N
Sat Nov 01 00:00:00 UTC 2014
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Sundberg TB,Choi HG,Song JH,Russell CN,Hussain MM,Graham DB,Khor B,Gagnon J,O'Connell DJ,Narayan K,Dančík V,Perez JR,Reinecker HC,Gray NS,Schreiber SL,Xavier RJ,Shamji AF
Tue Aug 26 00:00:00 UTC 2014
Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.
Proceedings of the National Academy of Sciences of the United States of America
Watanabe Y,Onodera A,Kanai U,Ichikawa T,Obata-Ninomiya K,Wada T,Kiuchi M,Iwamura C,Tumes DJ,Shinoda K,Yagi R,Motohashi S,Hirahara K,Nakayama T
Tue Sep 02 00:00:00 UTC 2014
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
Proceedings of the National Academy of Sciences of the United States of America
Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M
Tue Oct 14 00:00:00 UTC 2014
Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10.
Proceedings of the National Academy of Sciences of the United States of America
Engler DB,Reuter S,van Wijck Y,Urban S,Kyburz A,Maxeiner J,Martin H,Yogev N,Waisman A,Gerhard M,Cover TL,Taube C,Müller A
Tue Aug 12 00:00:00 UTC 2014
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
Proceedings of the National Academy of Sciences of the United States of America
Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS
Tue Jul 29 00:00:00 UTC 2014
MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Li C,Jiang S,Liu SQ,Lykken E,Zhao LT,Sevilla J,Zhu B,Li QJ
Tue Jul 08 00:00:00 UTC 2014
Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.
European journal of immunology
Scott CL,Tfp ZM,Beckham KS,Douce G,Mowat AM
Mon Dec 01 00:00:00 UTC 2014
Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
Immunology and cell biology
Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B
Wed Jan 01 00:00:00 UTC 2014
Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2.
Stem cells (Dayton, Ohio)
van Gastel N,Stegen S,Stockmans I,Moermans K,Schrooten J,Graf D,Luyten FP,Carmeliet G
Mon Sep 01 00:00:00 UTC 2014
Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
Stem cells (Dayton, Ohio)
Glenn JD,Smith MD,Calabresi PA,Whartenby KA
Wed Oct 01 00:00:00 UTC 2014
Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
Stem cells (Dayton, Ohio)
Lippmann ES,Estevez-Silva MC,Ashton RS
Tue Apr 01 00:00:00 UTC 2014
BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.
Stem cells (Dayton, Ohio)
Richter A,Valdimarsdottir L,Hrafnkelsdottir HE,Runarsson JF,Omarsdottir AR,Ward-van Oostwaard D,Mummery C,Valdimarsdottir G
Sat Mar 01 00:00:00 UTC 2014
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kim KD,Srikanth S,Tan YV,Yee MK,Jew M,Damoiseaux R,Jung ME,Shimizu S,An DS,Ribalet B,Waschek JA,Gwack Y
Wed Jan 01 00:00:00 UTC 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
Tue Apr 01 00:00:00 UTC 2014
Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y
Sat Feb 15 00:00:00 UTC 2014
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.
Journal of immunology (Baltimore, Md. : 1950)
Maier E,Werner D,Duschl A,Bohle B,Horejs-Hoeck J
Tue Jul 15 00:00:00 UTC 2014
Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.
Journal of immunology (Baltimore, Md. : 1950)
Fisher Y,Strominger I,Biton S,Nemirovsky A,Baron R,Monsonego A
Wed Jan 01 00:00:00 UTC 2014
Regulatory T cells in central nervous system injury: a double-edged sword.
Journal of immunology (Baltimore, Md. : 1950)
Walsh JT,Zheng J,Smirnov I,Lorenz U,Tung K,Kipnis J
Sat Nov 15 00:00:00 UTC 2014
CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stojanovic A,Fiegler N,Brunner-Weinzierl M,Cerwenka A
Thu May 01 00:00:00 UTC 2014
TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.
Journal of immunology (Baltimore, Md. : 1950)
Ogawa C,Tone Y,Tsuda M,Peter C,Waldmann H,Tone M
Wed Jan 01 00:00:00 UTC 2014
A negative feedback loop mediated by STAT3 limits human Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Purvis HA,Anderson AE,Young DA,Isaacs JD,Hilkens CM
Fri Aug 01 00:00:00 UTC 2014
Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kim EH,Gasper DJ,Lee SH,Plisch EH,Svaren J,Suresh M
Sat Feb 01 00:00:00 UTC 2014
IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Huang W,Jeong AR,Kannan AK,Huang L,August A
Mon Sep 01 00:00:00 UTC 2014
Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mota C,Nunes-Silva V,Pires AR,Matoso P,Victorino RM,Sousa AE,Caramalho I
Mon Dec 15 00:00:00 UTC 2014
MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Zhang J,Diao W,Wang D,Wei Y,Zhang CY,Zen K
Sat Feb 01 00:00:00 UTC 2014
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S
Fri Aug 15 00:00:00 UTC 2014
Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Pawaria S,Ramani K,Maers K,Liu Y,Kane LP,Levesque MC,Biswas PS
Wed Oct 01 00:00:00 UTC 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
Wed Jan 01 00:00:00 UTC 2014
A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950)
Dahlberg CI,He M,Visnes T,Torres ML,Cortizas EM,Verdun RE,Westerberg LS,Severinson E,Ström L
Sat Nov 01 00:00:00 UTC 2014
Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Du X,Shi H,Li J,Dong Y,Liang J,Ye J,Kong S,Zhang S,Zhong T,Yuan Z,Xu T,Zhuang Y,Zheng B,Geng JG,Tao W
Sat Feb 15 00:00:00 UTC 2014
Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine Mycoplasma pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Dobbs NA,Zhou X,Pulse M,Hodge LM,Schoeb TR,Simecka JW
Fri Aug 01 00:00:00 UTC 2014
Gene expression in the Gitr locus is regulated by NF-κB and Foxp3 through an enhancer.
Journal of immunology (Baltimore, Md. : 1950)
Tone Y,Kidani Y,Ogawa C,Yamamoto K,Tsuda M,Peter C,Waldmann H,Tone M
Tue Apr 15 00:00:00 UTC 2014
miRNA-940 reduction contributes to human Tetralogy of Fallot development.
Journal of cellular and molecular medicine
Liang D,Xu X,Deng F,Feng J,Zhang H,Liu Y,Zhang Y,Pan L,Liu Y,Zhang D,Li J,Liang X,Sun Y,Xiao J,Chen YH
Mon Sep 01 00:00:00 UTC 2014
Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other's signaling and stability.
The Journal of biological chemistry
Porsch H,Mehić M,Olofsson B,Heldin P,Heldin CH
Fri Jul 11 00:00:00 UTC 2014
Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other's signaling and stability.
The Journal of biological chemistry
Porsch H,Mehić M,Olofsson B,Heldin P,Heldin CH
Fri Jul 11 00:00:00 UTC 2014
Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1.
PloS one
Mia MM,Boersema M,Bank RA
100-21 was used in In vitro experiments to study the direct effects of Interleukin-1β (IL1β) on fibroblasts by investigating the effects of IL1β, TGFβ1, and IL1β in combination with TGFβ1 on myofibroblast formation, collagen synthesis and collagen modification (including prolyl hydroxylase, lysyl hydroxylase and lysyl oxidase), and matrix metalloproteinases (MMPs).
Fri May 29 00:00:00 UTC 2015
Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.
The Journal of biological chemistry
Hanihara-Tatsuzawa F,Miura H,Kobayashi S,Isagawa T,Okuma A,Manabe I,MaruYama T
Fri Nov 07 00:00:00 UTC 2014
SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.
The Journal of biological chemistry
Li S,Wang L,Zhao Q,Liu Y,He L,Xu Q,Sun X,Teng L,Cheng H,Ke Y
Fri Dec 05 00:00:00 UTC 2014
Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
The Journal of biological chemistry
Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A
Fri Jan 31 00:00:00 UTC 2014
Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.
Nature communications
Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC
Wed Sep 03 00:00:00 UTC 2014
A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation.
PloS one
Chen P,Zhang L,Weng T,Zhang S,Sun S,Chang M,Li Y,Zhang B,Zhang L
Sat Nov 08 00:00:00 UTC 2014
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 UTC 2013
Deterministic direct reprogramming of somatic cells to pluripotency.
Nature
Rais Y,Zviran A,Geula S,Gafni O,Chomsky E,Viukov S,Mansour AA,Caspi I,Krupalnik V,Zerbib M,Maza I,Mor N,Baran D,Weinberger L,Jaitin DA,Lara-Astiaso D,Blecher-Gonen R,Shipony Z,Mukamel Z,Hagai T,Gilad S,Amann-Zalcenstein D,Tanay A,Amit I,Novershtern N,Hanna JH
Thu Oct 03 00:00:00 UTC 2013
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.
Cell
Lee JC,Espéli M,Anderson CA,Linterman MA,Pocock JM,Williams NJ,Roberts R,Viatte S,Fu B,Peshu N,Hien TT,Phu NH,Wesley E,Edwards C,Ahmad T,Mansfield JC,Gearry R,Dunstan S,Williams TN,Barton A,Vinuesa CG,Parkes M,Lyons PA,Smith KG
Thu Sep 26 00:00:00 UTC 2013
A reversible gene trap collection empowers haploid genetics in human cells.
Nature methods
Bürckstümmer T,Banning C,Hainzl P,Schobesberger R,Kerzendorfer C,Pauler FM,Chen D,Them N,Schischlik F,Rebsamen M,Smida M,Fece de la Cruz F,Lapao A,Liszt M,Eizinger B,Guenzl PM,Blomen VA,Konopka T,Gapp B,Parapatics K,Maier B,Stöckl J,Fischl W,Salic S,Taba Casari MR,Knapp S,Bennett KL,Bock C,Colinge J,Kralovics R,Ammerer G,Casari G,Brummelkamp TR,Superti-Furga G,Nijman SM
Tue Oct 01 00:00:00 UTC 2013
Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.
The Journal of experimental medicine
Sitrin J,Ring A,Garcia KC,Benoist C,Mathis D
Mon Jun 03 00:00:00 UTC 2013
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.
The Journal of experimental medicine
Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C
Mon Jul 29 00:00:00 UTC 2013
BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid.
The Journal of experimental medicine
Wang C,Thangamani S,Kim M,Gu BH,Lee JH,Taparowsky EJ,Kim CH
Mon Mar 11 00:00:00 UTC 2013
Wnt4/β-catenin signaling in medullary kidney myofibroblasts.
Journal of the American Society of Nephrology : JASN
DiRocco DP,Kobayashi A,Taketo MM,McMahon AP,Humphreys BD
100-21 was used in Cell Culture to investigate the mechanisms involved in Wnt4 expression in adult kidney.
Sun Sep 01 00:00:00 UTC 2013
Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Li J,Wei B,Guo A,Liu C,Huang S,Du F,Fan W,Bao C,Pei G
Tue Apr 30 00:00:00 UTC 2013
Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery.
Proceedings of the National Academy of Sciences of the United States of America
Paiva RS,Lino AC,Bergman ML,Caramalho I,Sousa AE,Zelenay S,Demengeot J
Tue Apr 16 00:00:00 UTC 2013
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH
Tue Feb 05 00:00:00 UTC 2013
Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.
Proceedings of the National Academy of Sciences of the United States of America
Mak P,Chang C,Pursell B,Mercurio AM
Tue Mar 19 00:00:00 UTC 2013
Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America
Verjee LS,Verhoekx JS,Chan JK,Krausgruber T,Nicolaidou V,Izadi D,Davidson D,Feldmann M,Midwood KS,Nanchahal J
Tue Mar 05 00:00:00 UTC 2013
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.
Proceedings of the National Academy of Sciences of the United States of America
Ren S,Johnson BG,Kida Y,Ip C,Davidson KC,Lin SL,Kobayashi A,Lang RA,Hadjantonakis AK,Moon RT,Duffield JS
Tue Jan 22 00:00:00 UTC 2013
Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America
Priceman SJ,Kujawski M,Shen S,Cherryholmes GA,Lee H,Zhang C,Kruper L,Mortimer J,Jove R,Riggs AD,Yu H
Tue Aug 06 00:00:00 UTC 2013
Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Oertli M,Noben M,Engler DB,Semper RP,Reuter S,Maxeiner J,Gerhard M,Taube C,Müller A
Tue Feb 19 00:00:00 UTC 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 UTC 2013
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.
Experimental & molecular medicine
Moon SJ,Park JS,Heo YJ,Kang CM,Kim EK,Lim MA,Ryu JG,Park SJ,Park KS,Sung YC,Park SH,Kim HY,Min JK,Cho ML
Fri Oct 04 00:00:00 UTC 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 UTC 2013
Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.
Oncogene
Porsch H,Bernert B,Mehić M,Theocharis AD,Heldin CH,Heldin P
Thu Sep 12 00:00:00 UTC 2013
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress.
The Journal of cell biology
Ponugoti B,Xu F,Zhang C,Tian C,Pacios S,Graves DT
Mon Oct 28 00:00:00 UTC 2013
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress.
The Journal of cell biology
Ponugoti B,Xu F,Zhang C,Tian C,Pacios S,Graves DT
Mon Oct 28 00:00:00 UTC 2013
Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor.
Journal of immunology (Baltimore, Md. : 1950)
López-Soto A,Huergo-Zapico L,Galván JA,Rodrigo L,de Herreros AG,Astudillo A,Gonzalez S
Mon Apr 15 00:00:00 UTC 2013
Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Castriconi R,Dondero A,Bellora F,Moretta L,Castellano A,Locatelli F,Corrias MV,Moretta A,Bottino C
Wed May 15 00:00:00 UTC 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 UTC 2013
The road to memory: an early rest for the long journey.
Journal of immunology (Baltimore, Md. : 1950)
Ho LP,Yit PS,Ng LH,Linn YC,Zhao Y,Sun L,Ling KL,Chai Koh MB,Monica Shih MC,Li S,Wang XY,Tien SL,Goh YT
Sun Dec 01 00:00:00 UTC 2013
Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation process.
Journal of immunology (Baltimore, Md. : 1950)
Mikami N,Miyagi Y,Sueda K,Takatsuji M,Fukada S,Yamamoto H,Tsujikawa K
Mon Apr 15 00:00:00 UTC 2013
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Journal of immunology (Baltimore, Md. : 1950)
Beurel E,Kaidanovich-Beilin O,Yeh WI,Song L,Palomo V,Michalek SM,Woodgett JR,Harrington LE,Eldar-Finkelman H,Martinez A,Jope RS
Wed May 15 00:00:00 UTC 2013
Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.
Journal of immunology (Baltimore, Md. : 1950)
Rolla S,Ingoglia G,Bardina V,Silengo L,Altruda F,Novelli F,Tolosano E
Sun Dec 01 00:00:00 UTC 2013
IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier.
Journal of immunology (Baltimore, Md. : 1950)
Zeng Z,Kong X,Li F,Wei H,Sun R,Tian Z
Tue Oct 15 00:00:00 UTC 2013
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950)
Van Rompaey L,Galien R,van der Aar EM,Clement-Lacroix P,Nelles L,Smets B,Lepescheux L,Christophe T,Conrath K,Vandeghinste N,Vayssiere B,De Vos S,Fletcher S,Brys R,van 't Klooster G,Feyen JH,Menet C
Tue Oct 01 00:00:00 UTC 2013
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH
Mon Jul 15 00:00:00 UTC 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
Sat Jun 01 00:00:00 UTC 2013
Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.
Journal of immunology (Baltimore, Md. : 1950)
Eigenbrod T,Bode KA,Dalpke AH
Sat Jun 15 00:00:00 UTC 2013
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T
Mon Jul 15 00:00:00 UTC 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
Mon Apr 01 00:00:00 UTC 2013
Tumor-derived vascular pericytes anergize Th cells.
Journal of immunology (Baltimore, Md. : 1950)
Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S
Mon Jul 15 00:00:00 UTC 2013
Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
Journal of immunology (Baltimore, Md. : 1950)
Tamiya T,Ichiyama K,Kotani H,Fukaya T,Sekiya T,Shichita T,Honma K,Yui K,Matsuyama T,Nakao T,Fukuyama S,Inoue H,Nomura M,Yoshimura A
Sun Sep 01 00:00:00 UTC 2013
Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
Journal of immunology (Baltimore, Md. : 1950)
Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E
Mon Jul 15 00:00:00 UTC 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 UTC 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 UTC 2013
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.
Journal of immunology (Baltimore, Md. : 1950)
Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N
Sun Sep 15 00:00:00 UTC 2013
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Chattopadhyay G,Shevach EM
Sun Dec 15 00:00:00 UTC 2013
Inhibition of TGF-β1 signaling promotes central memory T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Takai S,Schlom J,Tucker J,Tsang KY,Greiner JW
Sun Sep 01 00:00:00 UTC 2013
Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Fitzgerald DC,Fonseca-Kelly Z,Cullimore ML,Safabakhsh P,Saris CJ,Zhang GX,Rostami A
Mon Apr 01 00:00:00 UTC 2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
Tue Oct 01 00:00:00 UTC 2013
Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.
Journal of immunology (Baltimore, Md. : 1950)
Cerdeira AS,Rajakumar A,Royle CM,Lo A,Husain Z,Thadhani RI,Sukhatme VP,Karumanchi SA,Kopcow HD
Mon Apr 15 00:00:00 UTC 2013
TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.
Stem cell research
McQualter JL,McCarty RC,Van der Velden J,O'Donoghue RJ,Asselin-Labat ML,Bozinovski S,Bertoncello I
Fri Nov 01 00:00:00 UTC 2013
Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
The Journal of biological chemistry
Spender LC,Carter MJ,O'Brien DI,Clark LJ,Yu J,Michalak EM,Happo L,Cragg MS,Inman GJ
Fri Feb 15 00:00:00 UTC 2013
Comparative analysis of gene transcripts for cell signaling receptors in bone marrow-derived hematopoietic stem/progenitor cell and mesenchymal stromal cell populations.
Stem cell research & therapy
Anam K,Davis TA
Mon Sep 16 00:00:00 UTC 2013
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
The Journal of biological chemistry
Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH
Fri Sep 20 00:00:00 UTC 2013
Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation.
The Journal of biological chemistry
Liu Y,Liu H,Meyer C,Li J,Nadalin S,Königsrainer A,Weng H,Dooley S,Ten Dijke P
Fri Oct 18 00:00:00 UTC 2013
TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.
PloS one
Liu Y,Yu S,Li Z,Ma J,Zhang Y,Wang H,Yang B,Wu C
Tue Feb 18 00:00:00 UTC 2014
Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction Impairment?
International journal of nephrology
Ghiggeri GM,Gigante M,Di Donato A
100-21 was used in Cell Culture to study how human podocytes can undergo EMT, but more importantly nephrin ablation itself can trigger this phenotypic transformation.
Mon Jan 06 00:00:00 UTC 2014
Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial-mesenchymal transition of cancer cells.
Cell death & disease
Lam CR,Tan C,Teo Z,Tay CY,Phua T,Wu YL,Cai PQ,Tan LP,Chen X,Zhu P,Tan NS
Thu Oct 10 00:00:00 UTC 2013
Signaling between transforming growth factor β (TGF-β) and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis.
The Journal of biological chemistry
Ding X,Park SI,McCauley LK,Wang CY
Fri Apr 12 00:00:00 UTC 2013
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
The Journal of biological chemistry
Li C,Ebert PJ,Li QJ
Fri Jun 28 00:00:00 UTC 2013
MicroRNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1), a new signaling route through which transforming growth factor-β Mediates the migration and actin dynamics of breast cancer cells.
The Journal of biological chemistry
Fils-Aimé N,Dai M,Guo J,El-Mousawi M,Kahramangil B,Neel JC,Lebrun JJ
Fri Apr 26 00:00:00 UTC 2013
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.
Nature
Lefebvre JL,Kostadinov D,Chen WV,Maniatis T,Sanes JR
Thu Aug 23 00:00:00 UTC 2012
EMT and dissemination precede pancreatic tumor formation.
Cell
Rhim AD,Mirek ET,Aiello NM,Maitra A,Bailey JM,McAllister F,Reichert M,Beatty GL,Rustgi AK,Vonderheide RH,Leach SD,Stanger BZ
Fri Jan 20 00:00:00 UTC 2012
Derivation of iPSCs in stirred suspension bioreactors.
Nature methods
Shafa M,Day B,Yamashita A,Meng G,Liu S,Krawetz R,Rancourt DE
Sun Apr 08 00:00:00 UTC 2012
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Immunity
Gulen MF,Bulek K,Xiao H,Yu M,Gao J,Sun L,Beurel E,Kaidanovich-Beilin O,Fox PL,DiCorleto PE,Wang JA,Qin J,Wald DN,Woodgett JR,Jope RS,Carman J,Dongre A,Li X
Fri Nov 16 00:00:00 UTC 2012
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.
Blood
Kim YC,Bhairavabhotla R,Yoon J,Golding A,Thornton AM,Tran DQ,Shevach EM
Thu Mar 22 00:00:00 UTC 2012
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
Blood
Hutter C,Kauer M,Simonitsch-Klupp I,Jug G,Schwentner R,Leitner J,Bock P,Steinberger P,Bauer W,Carlesso N,Minkov M,Gadner H,Stingl G,Kovar H,Kriehuber E
Thu Dec 20 00:00:00 UTC 2012
SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.
Cellular & molecular immunology
Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX
Sat Sep 01 00:00:00 UTC 2012
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.
The Journal of clinical investigation
Li X,Murray F,Koide N,Goldstone J,Dann SM,Chen J,Bertin S,Fu G,Weinstein LS,Chen M,Corr M,Eckmann L,Insel PA,Raz E
Thu Mar 01 00:00:00 UTC 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 UTC 2012
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection.
The Journal of clinical investigation
Oertli M,Sundquist M,Hitzler I,Engler DB,Arnold IC,Reuter S,Maxeiner J,Hansson M,Taube C,Quiding-Järbrink M,Müller A
Thu Mar 01 00:00:00 UTC 2012
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
The Journal of experimental medicine
Weiss JM,Bilate AM,Gobert M,Ding Y,Curotto de Lafaille MA,Parkhurst CN,Xiong H,Dolpady J,Frey AB,Ruocco MG,Yang Y,Floess S,Huehn J,Oh S,Li MO,Niec RE,Rudensky AY,Dustin ML,Littman DR,Lafaille JJ
Mon Sep 24 00:00:00 UTC 2012
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Proceedings of the National Academy of Sciences of the United States of America
Baud'huin M,Solban N,Cornwall-Brady M,Sako D,Kawamoto Y,Liharska K,Lath D,Bouxsein ML,Underwood KW,Ucran J,Kumar R,Pobre E,Grinberg A,Seehra J,Canalis E,Pearsall RS,Croucher PI
Tue Jul 24 00:00:00 UTC 2012
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions.
Proceedings of the National Academy of Sciences of the United States of America
Wang H,Shin DM,Abbasi S,Jain S,Kovalchuk AL,Beaty N,Chen S,Gonzalez-Garcia I,Morse HC
Tue Dec 04 00:00:00 UTC 2012
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Poppensieker K,Otte DM,Schürmann B,Limmer A,Dresing P,Drews E,Schumak B,Klotz L,Raasch J,Mildner A,Waisman A,Scheu S,Knolle P,Förster I,Prinz M,Maier W,Zimmer A,Alferink J
Tue Mar 06 00:00:00 UTC 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 UTC 2012
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Cell death and differentiation
Iovino S,Oriente F,Botta G,Cabaro S,Iovane V,Paciello O,Viggiano D,Perruolo G,Formisano P,Beguinot F
Sun Jul 01 00:00:00 UTC 2012
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Cell death and differentiation
Iovino S,Oriente F,Botta G,Cabaro S,Iovane V,Paciello O,Viggiano D,Perruolo G,Formisano P,Beguinot F
Sun Jul 01 00:00:00 UTC 2012
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.
Breast cancer research : BCR
Román-Pérez E,Casbas-Hernández P,Pirone JR,Rein J,Carey LA,Lubet RA,Mani SA,Amos KD,Troester MA
Mon Mar 19 00:00:00 UTC 2012
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.
The Journal of cell biology
Oikawa T,Oyama M,Kozuka-Hata H,Uehara S,Udagawa N,Saya H,Matsuo K
Mon May 14 00:00:00 UTC 2012
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.
The Journal of cell biology
Oikawa T,Oyama M,Kozuka-Hata H,Uehara S,Udagawa N,Saya H,Matsuo K
Mon May 14 00:00:00 UTC 2012
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
The Journal of cell biology
Winbanks CE,Weeks KL,Thomson RE,Sepulveda PV,Beyer C,Qian H,Chen JL,Allen JM,Lancaster GI,Febbraio MA,Harrison CA,McMullen JR,Chamberlain JS,Gregorevic P
Mon Jun 25 00:00:00 UTC 2012
Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.
PLoS pathogens
Sperling T,Ołdak M,Walch-Rückheim B,Wickenhauser C,Doorbar J,Pfister H,Malejczyk M,Majewski S,Keates AC,Smola S
Tue Jan 29 00:00:00 UTC 2013
Thiol-ene photopolymerizations provide a facile method to encapsulate proteins and maintain their bioactivity.
Biomacromolecules
McCall JD,Anseth KS
Mon Aug 13 00:00:00 UTC 2012
MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells.
Stem cells (Dayton, Ohio)
Liu L,Wang Y,Fan H,Zhao X,Liu D,Hu Y,Kidd AR,Bao J,Hou Y
Wed Aug 01 00:00:00 UTC 2012
Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.
Stem cells (Dayton, Ohio)
Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J
Thu Mar 01 00:00:00 UTC 2012
Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.
Stem cells (Dayton, Ohio)
Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J
Thu Mar 01 00:00:00 UTC 2012
Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity.
Arthritis research & therapy
Li Y,Zhao LD,Tong LS,Qian SN,Ren Y,Zhang L,Ding X,Chen Y,Wang YX,Zhang W,Zeng XF,Zhang FC,Tang FL,Zhang X,Ba DN,He W,Cao XT,Lipsky PE
Wed May 23 00:00:00 UTC 2012
WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication.
Laboratory investigation; a journal of technical methods and pathology
Carthy JM,Luo Z,McManus BM
100-21 was used in In vitro experiments to study the effect on Wnt ligands on the structure and function of vascular cells by treating vascular smooth muscle cells with recombinant Wnt3a and observe changes in the cell phenotype.
Wed Feb 01 00:00:00 UTC 2012
Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950)
Choi S,Kim HR,Leng L,Kang I,Jorgensen WL,Cho CS,Bucala R,Kim WU
Mon Oct 15 00:00:00 UTC 2012
Expression of Helios in peripherally induced Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Gottschalk RA,Corse E,Allison JP
Wed Feb 01 00:00:00 UTC 2012
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YG,Wang Y,Guo Z,Gu AD,Dan HC,Baldwin AS,Hao W,Wan YY
Thu Nov 01 00:00:00 UTC 2012
Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Mukherjee S,Giamberardino C,Thomas J,Evans K,Goto H,Ledford JG,Hsia B,Pastva AM,Wright JR
Wed Feb 01 00:00:00 UTC 2012
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Ramon HE,Beal AM,Liu Y,Worthen GS,Oliver PM
Sun Apr 15 00:00:00 UTC 2012
Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Journal of immunology (Baltimore, Md. : 1950)
Cedeno-Laurent F,Opperman M,Barthel SR,Kuchroo VK,Dimitroff CJ
Sun Apr 01 00:00:00 UTC 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 UTC 2012
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Hilliard BA,Monestier M,Cohen PL
Mon Oct 01 00:00:00 UTC 2012
Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR
Mon Oct 15 00:00:00 UTC 2012
Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)
Zhi L,Ustyugova IV,Chen X,Zhang Q,Wu MX
Wed Aug 15 00:00:00 UTC 2012
Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kalim KW,Basler M,Kirk CJ,Groettrup M
Mon Oct 15 00:00:00 UTC 2012
Antigen-specific transfer of functional programmed death ligand 1 from human APCs onto CD8+ T cells via trogocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Gary R,Voelkl S,Palmisano R,Ullrich E,Bosch JJ,Mackensen A
Sun Jan 15 00:00:00 UTC 2012
IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Newcomb DC,Boswell MG,Huckabee MM,Goleniewska K,Dulek DE,Reiss S,Lukacs NW,Kolls JK,Peebles RS
Wed Feb 01 00:00:00 UTC 2012
Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ye XZ,Xu SL,Xin YH,Yu SC,Ping YF,Chen L,Xiao HL,Wang B,Yi L,Wang QL,Jiang XF,Yang L,Zhang P,Qian C,Cui YH,Zhang X,Bian XW
Sun Jul 01 00:00:00 UTC 2012
Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Cuda CM,Li S,Liang S,Yin Y,Potula HH,Xu Z,Sengupta M,Chen Y,Butfiloski E,Baker H,Chang LJ,Dozmorov I,Sobel ES,Morel L
Sun Jan 15 00:00:00 UTC 2012
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D
Sun Jan 15 00:00:00 UTC 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 UTC 2012
Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yi H,Guo C,Yu X,Zuo D,Wang XY
Thu Nov 01 00:00:00 UTC 2012
Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Mukherjee S,Giamberardino C,Thomas JM,Gowdy K,Pastva AM,Wright JR
Tue May 01 00:00:00 UTC 2012
IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Sun K,Hsiao HH,Li M,Ames E,Bouchlaka M,Welniak LA,Hagino T,Jagdeo J,Pai CC,Chen M,Blazar BR,Abedi M,Murphy WJ
Wed Aug 15 00:00:00 UTC 2012
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Ding Y,Fang X,Wang R,Sun Z
Fri Jun 01 00:00:00 UTC 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 UTC 2012
Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.
Journal of immunology (Baltimore, Md. : 1950)
Perry DJ,Yin Y,Telarico T,Baker HV,Dozmorov I,Perl A,Morel L
Sun Jul 15 00:00:00 UTC 2012
Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection.
The Indian journal of medical research
Srivastava V,Khanna M,Sharma S,Kumar B
Mon Oct 01 00:00:00 UTC 2012
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
Molecular and cellular biology
Jurmeister S,Baumann M,Balwierz A,Keklikoglou I,Ward A,Uhlmann S,Zhang JD,Wiemann S,Sahin Ö
Wed Feb 01 00:00:00 UTC 2012
Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation.
Biotechnology and bioengineering
Cui X,Breitenkamp K,Lotz M,D'Lima D
Sat Sep 01 00:00:00 UTC 2012
Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.
Evidence-based complementary and alternative medicine : eCAM
Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M
Thu Aug 23 00:00:00 UTC 2012
Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion.
Histochemistry and cell biology
Raffa S,Leone L,Scrofani C,Monini S,Torrisi MR,Barbara M
Wed Aug 01 00:00:00 UTC 2012
Effects of high-mobility group a protein application on canine adipose-derived mesenchymal stem cells in vitro.
Veterinary medicine international
Ismail AA,Wagner S,Murua Escobar H,Willenbrock S,Sterenczak KA,Samy MT,Abd El-Aal AM,Nolte I,Wefstaedt P
Thu Aug 23 00:00:00 UTC 2012
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.
The Journal of biological chemistry
Xu Q,Isaji T,Lu Y,Gu W,Kondo M,Fukuda T,Du Y,Gu J
Fri May 11 00:00:00 UTC 2012
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
PloS one
Bastea LI,Döppler H,Balogun B,Storz P
Mon Jun 04 00:00:00 UTC 2012
Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.
The Journal of biological chemistry
Shapira KE,Gross A,Ehrlich M,Henis YI
Fri Aug 03 00:00:00 UTC 2012
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
PLoS genetics
Morel AP,Hinkal GW,Thomas C,Fauvet F,Courtois-Cox S,Wierinckx A,Devouassoux-Shisheboran M,Treilleux I,Tissier A,Gras B,Pourchet J,Puisieux I,Browne GJ,Spicer DB,Lachuer J,Ansieau S,Puisieux A
Wed Sep 26 00:00:00 UTC 2012
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
PloS one
Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H
Tue Feb 19 00:00:00 UTC 2013
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
Thu Feb 14 00:00:00 UTC 2013
De novo DNA methylation is required to restrict T helper lineage plasticity.
The Journal of biological chemistry
Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD
Fri Jun 29 00:00:00 UTC 2012
Immobilized metal affinity chromatography co-purifies TGF-β1 with histidine-tagged recombinant extracellular proteins.
PloS one
Kaur J,Reinhardt DP
Mon May 06 00:00:00 UTC 2013
Immobilized metal affinity chromatography co-purifies TGF-β1 with histidine-tagged recombinant extracellular proteins.
PloS one
Kaur J,Reinhardt DP
Mon May 06 00:00:00 UTC 2013
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 UTC 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 UTC 2012
Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.
PloS one
Andrieux G,Fattet L,Le Borgne M,Rimokh R,Théret N
Fri Jun 29 00:00:00 UTC 2012
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology
Gong D,Shi W,Yi SJ,Chen H,Groffen J,Heisterkamp N
Fri Jun 15 00:00:00 UTC 2012
RNA-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cells.
PloS one
Jääger K,Islam S,Zajac P,Linnarsson S,Neuman T
Wed Dec 12 00:00:00 UTC 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 UTC 2012
SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.
The Journal of biological chemistry
Kawamura I,Maeda S,Imamura K,Setoguchi T,Yokouchi M,Ishidou Y,Komiya S
Fri Aug 17 00:00:00 UTC 2012
A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis.
PloS one
Noda S,Asano Y,Akamata K,Aozasa N,Taniguchi T,Takahashi T,Ichimura Y,Toyama T,Sumida H,Yanaba K,Tada Y,Sugaya M,Kadono T,Sato S
Mon Aug 27 00:00:00 UTC 2012
Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
The Journal of biological chemistry
Choi JC,Wu W,Muchir A,Iwata S,Homma S,Worman HJ
Fri Nov 23 00:00:00 UTC 2012
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation.
PloS one
Zhang K,Lu Y,Yang P,Li C,Sun H,Tao D,Liu Y,Zhang S,Ma Y
Thu Jan 10 00:00:00 UTC 2013
Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells.
PloS one
Jounai K,Ikado K,Sugimura T,Ano Y,Braun J,Fujiwara D
Wed Oct 17 00:00:00 UTC 2012
Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts.
PloS one
Chen G,Chen H,Wang C,Peng Y,Sun L,Liu H,Liu F
Fri Aug 03 00:00:00 UTC 2012
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
The Journal of biological chemistry
Verma NK,Dempsey E,Long A,Davies A,Barry SP,Fallon PG,Volkov Y,Kelleher D
Fri Aug 03 00:00:00 UTC 2012
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.
PloS one
Kunisawa J,Hashimoto E,Ishikawa I,Kiyono H
Fri Jun 29 00:00:00 UTC 2012
One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating.
PloS one
Liu Y,Goldberg AJ,Dennis JE,Gronowicz GA,Kuhn LT
Fri Aug 03 00:00:00 UTC 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 UTC 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 UTC 2012
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death.
Cell death & disease
Chang JY,Chiang MF,Lin SR,Lee MH,He H,Chou PY,Chen SJ,Chen YA,Yang LY,Lai FJ,Hsieh CC,Hsieh TH,Sheu HM,Sze CI,Chang NS
Thu Apr 26 00:00:00 UTC 2012
TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2.
Biochimica et biophysica acta
Michael DR,Salter RC,Ramji DP
Mon Oct 01 00:00:00 UTC 2012
TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals.
International journal of biological sciences
Yoshida M,Okubo N,Chosa N,Hasegawa T,Ibi M,Kamo M,Kyakumoto S,Ishisaki A
Wed Nov 28 00:00:00 UTC 2012
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
PloS one
Boivin WA,Shackleford M,Vanden Hoek A,Zhao H,Hackett TL,Knight DA,Granville DJ
Tue Aug 28 00:00:00 UTC 2012
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PloS one
Liu Z,Zhang B,Liu K,Ding Z,Hu X
Tue Apr 02 00:00:00 UTC 2013
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PloS one
Liu Z,Zhang B,Liu K,Ding Z,Hu X
Tue Apr 02 00:00:00 UTC 2013
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
PloS one
Tauber S,Paulsen K,Wolf S,Synwoldt P,Pahl A,Schneider-Stock R,Ullrich O
Tue Apr 23 00:00:00 UTC 2013
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.
PloS one
Garcia-Gomez A,Ocio EM,Crusoe E,Santamaria C,Hernández-Campo P,Blanco JF,Sanchez-Guijo FM,Hernández-Iglesias T,Briñón JG,Fisac-Herrero RM,Lee FY,Pandiella A,San Miguel JF,Garayoa M
Mon Sep 10 00:00:00 UTC 2012
Calpain activity is essential in skin wound healing and contributes to scar formation.
PloS one
Nassar D,Letavernier E,Baud L,Aractingi S,Khosrotehrani K
Tue Jan 08 00:00:00 UTC 2013
Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.
PloS one
Hirschhorn T,Barizilay L,Smorodinsky NI,Ehrlich M
Tue Jan 29 00:00:00 UTC 2013
Protons sensitize epithelial cells to mesenchymal transition.
PloS one
Wang M,Hada M,Saha J,Sridharan DM,Pluth JM,Cucinotta FA
Wed Nov 28 00:00:00 UTC 2012
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.
PloS one
Saluja R,Delin I,Nilsson GP,Adner M
Wed Jan 16 00:00:00 UTC 2013
Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1.
Journal of neuroinflammation
Huang XQ,Zhang XY,Wang XR,Yu SY,Fang SH,Lu YB,Zhang WP,Wei EQ
Tue Jun 26 00:00:00 UTC 2012
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.
PloS one
Shi L,Chang Y,Yang Y,Zhang Y,Yu FS,Wu X
Fri Jun 29 00:00:00 UTC 2012
Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.
The Journal of biological chemistry
Li Z,Liu WH,Han S,Peng BW,Yin J,Wu YL,He XH,Li WX
Fri Aug 24 00:00:00 UTC 2012
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 UTC 2013
Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment.
PloS one
Rostovskaya M,Anastassiadis K
Tue Jun 11 00:00:00 UTC 2013
Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3.
Journal of experimental & clinical cancer research : CR
Zhu L,Qin H,Li PY,Xu SN,Pang HF,Zhao HZ,Li DM,Zhao Q
Thu Mar 29 00:00:00 UTC 2012
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
The Journal of biological chemistry
Lönn P,Vanlandewijck M,Raja E,Kowanetz M,Watanabe Y,Kowanetz K,Vasilaki E,Heldin CH,Moustakas A
Fri Apr 13 00:00:00 UTC 2012
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
The Journal of biological chemistry
Lönn P,Vanlandewijck M,Raja E,Kowanetz M,Watanabe Y,Kowanetz K,Vasilaki E,Heldin CH,Moustakas A
Fri Apr 13 00:00:00 UTC 2012
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell
Dang EV,Barbi J,Yang HY,Jinasena D,Yu H,Zheng Y,Bordman Z,Fu J,Kim Y,Yen HR,Luo W,Zeller K,Shimoda L,Topalian SL,Semenza GL,Dang CV,Pardoll DM,Pan F
Fri Sep 02 00:00:00 UTC 2011
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
Fri Mar 25 00:00:00 UTC 2011
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Nature immunology
Beal AM,Ramos-Hernández N,Riling CR,Nowelsky EA,Oliver PM
Sun Nov 13 00:00:00 UTC 2011
Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.
Blood
El Haddad N,Heathcote D,Moore R,Yang S,Azzi J,Mfarrej B,Atkinson M,Sayegh MH,Lee JS,Ashton-Rickardt PG,Abdi R
Thu Jan 27 00:00:00 UTC 2011
Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
Blood
Burton VJ,Ciuclan LI,Holmes AM,Rodman DM,Walker C,Budd DC
Thu Jan 06 00:00:00 UTC 2011
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.
Blood
Noubade R,Krementsov DN,Del Rio R,Thornton T,Nagaleekar V,Saligrama N,Spitzack A,Spach K,Sabio G,Davis RJ,Rincon M,Teuscher C
Thu Sep 22 00:00:00 UTC 2011
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.
Blood
Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P
Thu Apr 14 00:00:00 UTC 2011
SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.
Blood
Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C
Thu Feb 03 00:00:00 UTC 2011
Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST.
Blood
Tsai CC,Chen YJ,Yew TL,Chen LL,Wang JY,Chiu CH,Hung SC
Thu Jan 13 00:00:00 UTC 2011
Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation.
Blood
Quéré R,Karlsson G,Hertwig F,Rissler M,Lindqvist B,Fioretos T,Vandenberghe P,Slovak ML,Cammenga J,Karlsson S
Thu Jun 02 00:00:00 UTC 2011
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
Blood
Jiang S,Li C,Olive V,Lykken E,Feng F,Sevilla J,Wan Y,He L,Li QJ
Thu Nov 17 00:00:00 UTC 2011
Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.
Blood
Chung JS,Shiue LH,Duvic M,Pandya A,Cruz PD,Ariizumi K
Thu Mar 24 00:00:00 UTC 2011
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The Journal of clinical investigation
Barrow AD,Raynal N,Andersen TL,Slatter DA,Bihan D,Pugh N,Cella M,Kim T,Rho J,Negishi-Koga T,Delaisse JM,Takayanagi H,Lorenzo J,Colonna M,Farndale RW,Choi Y,Trowsdale J
Thu Sep 01 00:00:00 UTC 2011
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice.
The Journal of clinical investigation
Murray SE,Polesso F,Rowe AM,Basak S,Koguchi Y,Toren KG,Hoffmann A,Parker DC
Thu Dec 01 00:00:00 UTC 2011
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.
The Journal of experimental medicine
Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Nonoyama S,Karasuyama H,Minegishi Y
Mon Feb 14 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
Tue Mar 01 00:00:00 UTC 2011
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.
Proceedings of the National Academy of Sciences of the United States of America
Baschant U,Frappart L,Rauchhaus U,Bruns L,Reichardt HM,Kamradt T,Bräuer R,Tuckermann JP
Tue Nov 29 00:00:00 UTC 2011
SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos.
PLoS biology
Wu MY,Ramel MC,Howell M,Hill CS
Tue Feb 15 00:00:00 UTC 2011
SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.
The Journal of cell biology
Rivera LB,Brekken RA
Mon Jun 27 00:00:00 UTC 2011
EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
The Journal of cell biology
Danussi C,Petrucco A,Wassermann B,Pivetta E,Modica TM,Del Bel Belluz L,Colombatti A,Spessotto P
Mon Oct 03 00:00:00 UTC 2011
Affinity peptides protect transforming growth factor beta during encapsulation in poly(ethylene glycol) hydrogels.
Biomacromolecules
McCall JD,Lin CC,Anseth KS
Mon Apr 11 00:00:00 UTC 2011
The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun.
The international journal of biochemistry & cell biology
Salter RC,Arnaoutakis K,Michael DR,Singh NN,Ashlin TG,Buckley ML,Kwan AP,Ramji DP
Sun May 01 00:00:00 UTC 2011
Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy
Sobel ES,Brusko TM,Butfiloski EJ,Hou W,Li S,Cuda CM,Abid AN,Reeves WH,Morel L
Mon Jun 27 00:00:00 UTC 2011
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lei L,Zhang Y,Yao W,Kaplan MH,Zhou B
Tue Feb 15 00:00:00 UTC 2011
A major role for Bim in regulatory T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Chougnet CA,Tripathi P,Lages CS,Raynor J,Sholl A,Fink P,Plas DR,Hildeman DA
Sat Jan 01 00:00:00 UTC 2011
Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee JH,Ulrich B,Cho J,Park J,Kim CH
Mon Aug 15 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 UTC 2011
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Wang L,Du C,Lv J,Wei W,Cui Y,Xie X
Thu Sep 01 00:00:00 UTC 2011
Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Beurel E,Yeh WI,Michalek SM,Harrington LE,Jope RS
Tue Feb 01 00:00:00 UTC 2011
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.
Journal of immunology (Baltimore, Md. : 1950)
Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q
Sat Oct 15 00:00:00 UTC 2011
Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,van den Bosch A,Wierenga AT,Janssen HL,Coffer PJ,Woltman AM
Wed Jun 15 00:00:00 UTC 2011
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
Journal of immunology (Baltimore, Md. : 1950)
Peng DJ,Zeng M,Muromoto R,Matsuda T,Shimoda K,Subramaniam M,Spelsberg TC,Wei WZ,Venuprasad K
Sun May 15 00:00:00 UTC 2011
The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Fujimoto M,Nakano M,Terabe F,Kawahata H,Ohkawara T,Han Y,Ripley B,Serada S,Nishikawa T,Kimura A,Nomura S,Kishimoto T,Naka T
Sat Jan 01 00:00:00 UTC 2011
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K
Sat Jan 15 00:00:00 UTC 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 UTC 2011
A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
Journal of immunology (Baltimore, Md. : 1950)
Fiancette R,Rouaud P,Vincent-Fabert C,Laffleur B,Magnone V,Cogné M,Denizot Y
Thu Dec 01 00:00:00 UTC 2011
Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.
Journal of immunology (Baltimore, Md. : 1950)
Dunnick WA,Shi J,Zerbato JM,Fontaine CA,Collins JT
Tue Nov 01 00:00:00 UTC 2011
IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Y,Meyer C,Müller A,Herweck F,Li Q,Müllenbach R,Mertens PR,Dooley S,Weng HL
Thu Sep 01 00:00:00 UTC 2011
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Journal of immunology (Baltimore, Md. : 1950)
Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH
Fri Apr 01 00:00:00 UTC 2011
CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Kurotaki D,Kon S,Bae K,Ito K,Matsui Y,Nakayama Y,Kanayama M,Kimura C,Narita Y,Nishimura T,Iwabuchi K,Mack M,van Rooijen N,Sakaguchi S,Uede T,Morimoto J
Tue Feb 15 00:00:00 UTC 2011
Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.
Journal of immunology (Baltimore, Md. : 1950)
Denning TL,Norris BA,Medina-Contreras O,Manicassamy S,Geem D,Madan R,Karp CL,Pulendran B
Fri Jul 15 00:00:00 UTC 2011
Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Raffin C,Raimbaud I,Valmori D,Ayyoub M
Tue Nov 15 00:00:00 UTC 2011
Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Duan W,So T,Mehta AK,Choi H,Croft M
Thu Dec 15 00:00:00 UTC 2011
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Chen Q,Kim YC,Laurence A,Punkosdy GA,Shevach EM
Wed Jun 01 00:00:00 UTC 2011
Platelet-activating factor induces Th17 cell differentiation.
Mediators of inflammation
Drolet AM,Thivierge M,Turcotte S,Hanna D,Maynard B,Stankovà J,Rola-Pleszczynski M
Tue May 15 00:00:00 UTC 2012
Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation.
Cell transplantation
Ehnert S,Seeliger C,Vester H,Schmitt A,Saidy-Rad S,Lin J,Neumaier M,Gillen S,Kleeff J,Friess H,Burkhart J,Stöckle U,Nüssler AK
Thu Mar 08 00:00:00 UTC 2012
TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB.
Connective tissue research
Wang Y,Tang Z,Xue R,Singh GK,Lv Y,Shi K,Cai K,Deng L,Yang L
Wed Jun 01 00:00:00 UTC 2011
[Survey on the awareness of community pharmacists about raising pharmaceutical questions regarding prescriptions issued by physicians].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Shikamura Y,Takahashi J,Oyama A,Negishi K,Ijyuin K,Kamimura N,Aoyama T
Fri Feb 24 00:00:00 UTC 2012
Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.
PloS one
Xiao L,Fu ZR,Liu F,Zhang LD,Shi XM,Shen XY,Ni ZJ,Fu H,Li RD,Cao XT,Ding GS,Wang QX
Tue Dec 27 00:00:00 UTC 2011
Critical role of TCF-1 in repression of the IL-17 gene.
PloS one
Ma J,Wang R,Fang X,Ding Y,Sun Z
Tue Feb 28 00:00:00 UTC 2012
TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4.
The Journal of biological chemistry
Winbanks CE,Wang B,Beyer C,Koh P,White L,Kantharidis P,Gregorevic P
Fri Apr 22 00:00:00 UTC 2011
Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
The Journal of biological chemistry
Morén A,Raja E,Heldin CH,Moustakas A
Fri Jan 07 00:00:00 UTC 2011
Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.
The Journal of biological chemistry
Haudenschild DR,Hong E,Yik JH,Chromy B,Mörgelin M,Snow KD,Acharya C,Takada Y,Di Cesare PE
Fri Dec 16 00:00:00 UTC 2011
TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates.
PloS one
L'Abbate C,Cipriano I,Pérez-Hurtado EC,Leão SC,Carneiro CR,Machado J
Wed Nov 02 00:00:00 UTC 2011
Tension-compression loading with chemical stimulation results in additive increases to functional properties of anatomic meniscal constructs.
PloS one
Huey DJ,Athanasiou KA
Thu May 03 00:00:00 UTC 2012
Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes.
Fibrogenesis & tissue repair
Ekert JE,Murray LA,Das AM,Sheng H,Giles-Komar J,Rycyzyn MA
Wed Oct 19 00:00:00 UTC 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 UTC 2011
Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts.
BMC musculoskeletal disorders
Satish L,Gallo PH,Baratz ME,Johnson S,Kathju S
Wed May 25 00:00:00 UTC 2011
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
PloS one
Patton DT,Wilson MD,Rowan WC,Soond DR,Okkenhaug K
Tue Mar 01 00:00:00 UTC 2011
Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells.
The Journal of biological chemistry
Sun J,He H,Xiong Y,Lu S,Shen J,Cheng A,Chang WC,Hou MF,Lancaster JM,Kim M,Yang S
Fri Nov 11 00:00:00 UTC 2011
Calcium input potentiates the transforming growth factor (TGF)-beta1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte.
The Journal of biological chemistry
Cailotto F,Reboul P,Sebillaud S,Netter P,Jouzeau JY,Bianchi A
Fri Jun 03 00:00:00 UTC 2011
Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model.
BMC musculoskeletal disorders
Mokbel AN,El Tookhy OS,Shamaa AA,Rashed LA,Sabry D,El Sayed AM
Tue Nov 15 00:00:00 UTC 2011
Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior.
PloS one
Bhat A,Boyadjiev SA,Senders CW,Leach JK
Mon Feb 13 00:00:00 UTC 2012
Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis.
PloS one
Bhattacharyya S,Sargent JL,Du P,Lin S,Tourtellotte WG,Takehara K,Whitfield ML,Varga J
Fri Feb 03 00:00:00 UTC 2012
Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.
PloS one
Donati C,Marseglia G,Magi A,Serratì S,Cencetti F,Bernacchioni C,Nannetti G,Benelli M,Brunelli S,Torricelli F,Cossu G,Bruni P
Fri Sep 23 00:00:00 UTC 2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
Thu Sep 29 00:00:00 UTC 2011
Induction of B-cell lymphoma by UVB radiation in p53 haploinsufficient mice.
BMC cancer
Puebla-Osorio N,Miyahara Y,Coimbatore S,Limón-Flores AY,Kazimi N,Ullrich SE,Zhu C
Wed Jan 26 00:00:00 UTC 2011
NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
PloS one
Yang J,Zheng J,Wu L,Shi M,Zhang H,Wang X,Xia N,Wang D,Liu X,Yao L,Li Y,Dou K
Mon Mar 26 00:00:00 UTC 2012
NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats.
PloS one
Yang J,Zheng J,Wu L,Shi M,Zhang H,Wang X,Xia N,Wang D,Liu X,Yao L,Li Y,Dou K
Mon Mar 26 00:00:00 UTC 2012
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 UTC 2011
Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation.
PloS one
Yang J,Yang X,Chu Y,Li M
Wed Feb 16 00:00:00 UTC 2011
IκB kinase β regulates epithelium migration during corneal wound healing.
PloS one
Chen L,Meng Q,Kao W,Xia Y
Mon Jan 17 00:00:00 UTC 2011
Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces.
PloS one
Li X,Chu J,Wang A,Zhu Y,Chu WK,Yang L,Li S
100-21 was used in Cell Culture to demonstrate that mechanical strain regulates the differentiation of neural crest stem cells (NCSCs) in a manner dependent on biochemical factors and the differentiation stage of NCSCs.
Mon Feb 13 00:00:00 UTC 2012
Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age.
PloS one
Dexheimer V,Mueller S,Braatz F,Richter W
Thu Feb 02 00:00:00 UTC 2012
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.
The Journal of biological chemistry
Velasco J,Li J,DiPietro L,Stepp MA,Sandy JD,Plaas A
Fri Jul 22 00:00:00 UTC 2011
Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.
Respiratory research
Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G
Mon Sep 26 00:00:00 UTC 2011
Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells.
PloS one
Vazão H,das Neves RP,Grãos M,Ferreira L
Thu Mar 10 00:00:00 UTC 2011
Listeria monocytogenes impairs SUMOylation for efficient infection.
Nature
Ribet D,Hamon M,Gouin E,Nahori MA,Impens F,Neyret-Kahn H,Gevaert K,Vandekerckhove J,Dejean A,Cossart P
Thu Apr 22 00:00:00 UTC 2010
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature
Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H
Thu Apr 29 00:00:00 UTC 2010
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Immunity
Gulen MF,Kang Z,Bulek K,Youzhong W,Kim TW,Chen Y,Altuntas CZ,Sass Bak-Jensen K,McGeachy MJ,Do JS,Xiao H,Delgoffe GM,Min B,Powell JD,Tuohy VK,Cua DJ,Li X
Fri Jan 29 00:00:00 UTC 2010
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.
Cancer cell
Mak P,Leav I,Pursell B,Bae D,Yang X,Taglienti CA,Gouvin LM,Sharma VM,Mercurio AM
Tue Apr 13 00:00:00 UTC 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 UTC 2010
Low-strength T-cell activation promotes Th17 responses.
Blood
Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM
Thu Dec 02 00:00:00 UTC 2010
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.
Blood
Mleczko-Sanecka K,Casanovas G,Ragab A,Breitkopf K,Müller A,Boutros M,Dooley S,Hentze MW,Muckenthaler MU
Thu Apr 01 00:00:00 UTC 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 UTC 2010
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
The Journal of clinical investigation
Biswas PS,Gupta S,Chang E,Song L,Stirzaker RA,Liao JK,Bhagat G,Pernis AB
Wed Sep 01 00:00:00 UTC 2010
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.
The Journal of clinical investigation
Bielesz B,Sirin Y,Si H,Niranjan T,Gruenwald A,Ahn S,Kato H,Pullman J,Gessler M,Haase VH,Susztak K
Mon Nov 01 00:00:00 UTC 2010
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
The Journal of clinical investigation
Hannigan A,Smith P,Kalna G,Lo Nigro C,Orange C,O'Brien DI,Shah R,Syed N,Spender LC,Herrera B,Thurlow JK,Lattanzio L,Monteverde M,Maurer ME,Buffa FM,Mann J,Chu DC,West CM,Patridge M,Oien KA,Cooper JA,Frame MC,Harris AL,Hiller L,Nicholson LJ,Gasco M,Crook T,Inman GJ
Sun Aug 01 00:00:00 UTC 2010
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.
The Journal of experimental medicine
Harada Y,Harada Y,Elly C,Ying G,Paik JH,DePinho RA,Liu YC
Mon Jul 05 00:00:00 UTC 2010
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis.
The Journal of experimental medicine
Liu G,Friggeri A,Yang Y,Milosevic J,Ding Q,Thannickal VJ,Kaminski N,Abraham E
Mon Aug 02 00:00:00 UTC 2010
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice.
The Journal of experimental medicine
Schallenberg S,Tsai PY,Riewaldt J,Kretschmer K
Mon Jul 05 00:00:00 UTC 2010
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.
The Journal of experimental medicine
Gottschalk RA,Corse E,Allison JP
Mon Aug 02 00:00:00 UTC 2010
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.
The Journal of experimental medicine
Wang YH,Voo KS,Liu B,Chen CY,Uygungil B,Spoede W,Bernstein JA,Huston DP,Liu YJ
Mon Oct 25 00:00:00 UTC 2010
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.
The Journal of experimental medicine
Hashimoto M,Hirota K,Yoshitomi H,Maeda S,Teradaira S,Akizuki S,Prieto-Martin P,Nomura T,Sakaguchi N,Köhl J,Heyman B,Takahashi M,Fujita T,Mimori T,Sakaguchi S
Mon Jun 07 00:00:00 UTC 2010
Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung.
Proceedings of the National Academy of Sciences of the United States of America
McQualter JL,Yuen K,Williams B,Bertoncello I
Tue Jan 26 00:00:00 UTC 2010
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.
Proceedings of the National Academy of Sciences of the United States of America
Datta SK,Sabet M,Nguyen KP,Valdez PA,Gonzalez-Navajas JM,Islam S,Mihajlov I,Fierer J,Insel PA,Webster NJ,Guiney DG,Raz E
Tue Jun 08 00:00:00 UTC 2010
Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors.
Proceedings of the National Academy of Sciences of the United States of America
Valmori D,Raffin C,Raimbaud I,Ayyoub M
Tue Nov 09 00:00:00 UTC 2010
TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.
Cell death and differentiation
Huser CA,Pringle MA,Heath VJ,Bell AK,Kendrick H,Smalley MJ,Crighton D,Ryan KM,Gusterson BA,Stein T
Mon Feb 01 00:00:00 UTC 2010
Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells.
Stem cells (Dayton, Ohio)
Mohr A,Albarenque SM,Deedigan L,Yu R,Reidy M,Fulda S,Zwacka RM
Mon Nov 01 00:00:00 UTC 2010
Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies.
Stem cells (Dayton, Ohio)
Kopper O,Giladi O,Golan-Lev T,Benvenisty N
Fri Jan 01 00:00:00 UTC 2010
Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells.
Stem cells (Dayton, Ohio)
Kurpinski K,Lam H,Chu J,Wang A,Kim A,Tsay E,Agrawal S,Schaffer DV,Li S
Thu Apr 01 00:00:00 UTC 2010
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lissilaa R,Buatois V,Magistrelli G,Williams AS,Jones GW,Herren S,Shang L,Malinge P,Guilhot F,Chatel L,Hatterer E,Jones SA,Kosco-Vilbois MH,Ferlin WG
Mon Nov 01 00:00:00 UTC 2010
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Thornton AM,Korty PE,Tran DQ,Wohlfert EA,Murray PE,Belkaid Y,Shevach EM
Thu Apr 01 00:00:00 UTC 2010
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Thornton AM,Korty PE,Tran DQ,Wohlfert EA,Murray PE,Belkaid Y,Shevach EM
Thu Apr 01 00:00:00 UTC 2010
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.
Journal of immunology (Baltimore, Md. : 1950)
Wang C,Kang SG,HogenEsch H,Love PE,Kim CH
Sat May 15 00:00:00 UTC 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
Sun Aug 15 00:00:00 UTC 2010
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Iwakura Y,Yoshikai Y
Wed Dec 15 00:00:00 UTC 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 UTC 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 UTC 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 UTC 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 UTC 2010
T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
Journal of immunology (Baltimore, Md. : 1950)
Giroux M,Delisle JS,O'Brien A,Hébert MJ,Perreault C
Sun Aug 01 00:00:00 UTC 2010
T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
Journal of immunology (Baltimore, Md. : 1950)
Giroux M,Delisle JS,O'Brien A,Hébert MJ,Perreault C
Sun Aug 01 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component.
Cerebral cortex (New York, N.Y. : 1991)
Vogel T,Ahrens S,Büttner N,Krieglstein K
Mon Mar 01 00:00:00 UTC 2010
Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes.
PPAR research
Poleni PE,Etienne S,Velot E,Netter P,Bianchi A
Thu Jul 14 00:00:00 UTC 2011
Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells.
Tissue engineering. Part A
Zhao L,Jiang S,Hantash BM
Mon Feb 01 00:00:00 UTC 2010
Chondrogenesis of human mesenchymal stem cells by local transforming growth factor-beta delivery in a biphasic resorbable carrier.
Tissue engineering. Part A
Dickhut A,Dexheimer V,Martin K,Lauinger R,Heisel C,Richter W
Mon Feb 01 00:00:00 UTC 2010
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
Molecular biology of the cell
Moyano JV,Greciano PG,Buschmann MM,Koch M,Matlin KS
100-21 was used in Enzyme-linked immunosorbent assay to study the molecular signals involved in laminin (LM)-332 upregulation in renal epithelial regeneration after ischemic injury.
Mon Nov 01 00:00:00 UTC 2010
SMAD2 is essential for TGF beta-mediated Th17 cell generation.
The Journal of biological chemistry
Malhotra N,Robertson E,Kang J
Fri Sep 17 00:00:00 UTC 2010
Upregulation of Id1 by Epstein-Barr virus-encoded LMP1 confers resistance to TGFbeta-mediated growth inhibition.
Molecular cancer
Lo AK,Dawson CW,Lo KW,Yu Y,Young LS
Fri Jun 18 00:00:00 UTC 2010
Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.
PloS one
Domingues HS,Mues M,Lassmann H,Wekerle H,Krishnamoorthy G
Mon Nov 29 00:00:00 UTC 2010
TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.
PloS one
Ehnert S,Baur J,Schmitt A,Neumaier M,Lucke M,Dooley S,Vester H,Wildemann B,Stöckle U,Nussler AK
Mon Nov 22 00:00:00 UTC 2010
CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
The Journal of biological chemistry
Berna MJ,Seiz O,Nast JF,Benten D,Bläker M,Koch J,Lohse AW,Pace A
Fri Dec 10 00:00:00 UTC 2010
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.
Molecular & cellular proteomics : MCP
Alexopoulos LG,Saez-Rodriguez J,Cosgrove BD,Lauffenburger DA,Sorger PK
Wed Sep 01 00:00:00 UTC 2010
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
PloS one
Rodrigues Díez R,Rodrigues-Díez R,Lavoz C,Rayego-Mateos S,Civantos E,Rodríguez-Vita J,Mezzano S,Ortiz A,Egido J,Ruiz-Ortega M
Tue Nov 30 00:00:00 UTC 2010
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}.
The Journal of biological chemistry
Louafi F,Martinez-Nunez RT,Sanchez-Elsner T
Fri Dec 31 00:00:00 UTC 2010
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Self/nonself
Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM
100-21 was used in Cell Culture to develop a nanoparticulate drug delivery platform from poly(lactic-co-glycolic acid) capable of encapsulating and releasing retinoic acid.
Fri Oct 01 00:00:00 UTC 2010
Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex.
The Journal of biological chemistry
Walton KL,Makanji Y,Chen J,Wilce MC,Chan KL,Robertson DM,Harrison CA
Fri May 28 00:00:00 UTC 2010
Analysis of innate defences against Plasmodium falciparum in immunodeficient mice.
Malaria journal
Arnold L,Tyagi RK,Mejia P,Van Rooijen N,Pérignon JL,Druilhe P
Fri Jul 09 00:00:00 UTC 2010
Identification of five developmental processes during chondrogenic differentiation of embryonic stem cells.
PloS one
Yamashita A,Nishikawa S,Rancourt DE
Mon Jun 07 00:00:00 UTC 2010
Retinoic acid mediates regulation of network formation by COUP-TFII and VE-cadherin expression by TGFbeta receptor kinase in breast cancer cells.
PloS one
Prahalad P,Dakshanamurthy S,Ressom H,Byers SW
Tue Apr 06 00:00:00 UTC 2010
The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.
The Journal of biological chemistry
Carracedo S,Lu N,Popova SN,Jonsson R,Eckes B,Gullberg D
Fri Apr 02 00:00:00 UTC 2010
Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.
The Journal of biological chemistry
Ohtake-Niimi S,Kondo S,Ito T,Kakehi S,Ohta T,Habuchi H,Kimata K,Habuchi O
Fri Jul 02 00:00:00 UTC 2010
Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation.
The Journal of biological chemistry
Tang Y,Urs S,Boucher J,Bernaiche T,Venkatesh D,Spicer DB,Vary CP,Liaw L
Fri Jun 04 00:00:00 UTC 2010
Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase.
PloS one
Shan B,Hagood JS,Zhuo Y,Nguyen HT,MacEwen M,Morris GF,Lasky JA
Mon Jul 19 00:00:00 UTC 2010
Implantation increases tensile strength and collagen content of self-assembled tendon constructs.
Journal of applied physiology (Bethesda, Md. : 1985)
Calve S,Lytle IF,Grosh K,Brown DL,Arruda EM
100-21 was used in Cell Culture to hypothesize that the in vitro environment lacks certain environmental stimuli and that implantation in vivo would facilitate the maturation of engineered tissues.
Thu Apr 01 00:00:00 UTC 2010
Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells.
PloS one
Ochiel DO,Ochsenbauer C,Kappes JC,Ghosh M,Fahey JV,Wira CR
Tue Dec 14 00:00:00 UTC 2010
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.
Cell death & disease
Lee MH,Lin SR,Chang JY,Schultz L,Heath J,Hsu LJ,Kuo YM,Hong Q,Chiang MF,Gong CX,Sze CI,Chang NS
Thu Dec 23 00:00:00 UTC 2010
Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro.
BMC cell biology
Wang T,Mao FF,Lai W,Li W,Yu W,Wang Z,Zhang L,Zhang J,Niu J,Zhang X,Lahn BT,Xiang AP
Sat Jun 19 00:00:00 UTC 2010
Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.
PloS one
Kido S,Kuriwaka-Kido R,Umino-Miyatani Y,Endo I,Inoue D,Taniguchi H,Inoue Y,Imamura T,Matsumoto T
Wed Sep 29 00:00:00 UTC 2010
Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.
The Journal of biological chemistry
Leenders JJ,Wijnen WJ,Hiller M,van der Made I,Lentink V,van Leeuwen REW,Herias V,Pokharel S,Heymans S,de Windt LJ,Høydal MA,Pinto YM,Creemers EE
Fri Aug 27 00:00:00 UTC 2010
PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1.
Journal of experimental & clinical cancer research : CR
Chen Y,Yu G,Yu D,Zhu M
Thu Aug 05 00:00:00 UTC 2010
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.
Cell
Dupont S,Mamidi A,Cordenonsi M,Montagner M,Zacchigna L,Adorno M,Martello G,Stinchfield MJ,Soligo S,Morsut L,Inui M,Moro S,Modena N,Argenton F,Newfeld SJ,Piccolo S
Fri Jan 09 00:00:00 UTC 2009
Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.
Immunity
Desvignes L,Ernst JD
Fri Dec 18 00:00:00 UTC 2009
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
Immunity
Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD
Fri Jun 19 00:00:00 UTC 2009
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.
Immunity
Yu A,Zhu L,Altman NH,Malek TR
Fri Feb 20 00:00:00 UTC 2009
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.
Immunity
Chung Y,Chang SH,Martinez GJ,Yang XO,Nurieva R,Kang HS,Ma L,Watowich SS,Jetten AM,Tian Q,Dong C
Fri Apr 17 00:00:00 UTC 2009
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells.
Nature immunology
Trifari S,Kaplan CD,Tran EH,Crellin NK,Spits H
Sat Aug 01 00:00:00 UTC 2009
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.
Nature cell biology
Giampieri S,Manning C,Hooper S,Jones L,Hill CS,Sahai E
Sun Nov 01 00:00:00 UTC 2009
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
Blood
Jin W,Zhou XF,Yu J,Cheng X,Sun SC
Thu Jun 25 00:00:00 UTC 2009
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.
Blood
Tipping AJ,Pina C,Castor A,Hong D,Rodrigues NP,Lazzari L,May GE,Jacobsen SE,Enver T
Thu Mar 19 00:00:00 UTC 2009
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.
Blood
Tran DQ,Andersson J,Hardwick D,Bebris L,Illei GG,Shevach EM
Thu May 21 00:00:00 UTC 2009
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
Blood
Van den Bossche J,Bogaert P,van Hengel J,Guérin CJ,Berx G,Movahedi K,Van den Bergh R,Pereira-Fernandes A,Geuns JM,Pircher H,Dorny P,Grooten J,De Baetselier P,Van Ginderachter JA
Thu Nov 19 00:00:00 UTC 2009
Activin-A attenuates several human natural killer cell functions.
Blood
Robson NC,Wei H,McAlpine T,Kirkpatrick N,Cebon J,Maraskovsky E
Thu Apr 02 00:00:00 UTC 2009
Functional Epstein-Barr virus reservoir in plasma cells derived from infected peripheral blood memory B cells.
Blood
Al Tabaa Y,Tuaillon E,Bollore K,Foulongne V,Petitjean G,Seigneurin JM,Duperray C,Desgranges C,Vendrell JP
Thu Jan 15 00:00:00 UTC 2009
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations.
Blood
Carlson MJ,West ML,Coghill JM,Panoskaltsis-Mortari A,Blazar BR,Serody JS
Thu Feb 05 00:00:00 UTC 2009
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production.
Blood
Fang C,Zhang X,Miwa T,Song WC
Thu Jul 30 00:00:00 UTC 2009
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders.
Blood
Wilcox RA,Feldman AL,Wada DA,Yang ZZ,Comfere NI,Dong H,Kwon ED,Novak AJ,Markovic SN,Pittelkow MR,Witzig TE,Ansell SM
Thu Sep 03 00:00:00 UTC 2009
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice.
The Journal of clinical investigation
Haak S,Croxford AL,Kreymborg K,Heppner FL,Pouly S,Becher B,Waisman A
Thu Jan 01 00:00:00 UTC 2009
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
The Journal of experimental medicine
Klotz L,Burgdorf S,Dani I,Saijo K,Flossdorf J,Hucke S,Alferink J,Nowak N,Beyer M,Mayer G,Langhans B,Klockgether T,Waisman A,Eberl G,Schultze J,Famulok M,Kolanus W,Glass C,Kurts C,Knolle PA
Mon Sep 28 00:00:00 UTC 2009
The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization.
Biomaterials
Freeman I,Cohen S
Wed Apr 01 00:00:00 UTC 2009
Effects of TGF-beta1 and hydrostatic pressure on meniscus cell-seeded scaffolds.
Biomaterials
Gunja NJ,Uthamanthil RK,Athanasiou KA
Sun Feb 01 00:00:00 UTC 2009
Characterization and regulation of bv8 in human blood cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhong C,Qu X,Tan M,Meng YG,Ferrara N
Wed Apr 15 00:00:00 UTC 2009
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y
Tue Sep 15 00:00:00 UTC 2009
In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray.
Leukemia
Hoves S,Aigner M,Pfeiffer C,Laumer M,Obermann EC,Mackensen A
Fri May 01 00:00:00 UTC 2009
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Argaw AT,Gurfein BT,Zameer A,Snyder BJ,Ge C,Lu QR,Rowitch DH,Raine CS,Brosnan CF,John GR
Tue Nov 10 00:00:00 UTC 2009
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Tran DQ,Andersson J,Wang R,Ramsey H,Unutmaz D,Shevach EM
Tue Aug 11 00:00:00 UTC 2009
TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.
Cell death and differentiation
Spender LC,O'Brien DI,Simpson D,Dutt D,Gregory CD,Allday MJ,Clark LJ,Inman GJ
Wed Apr 01 00:00:00 UTC 2009
Loss of discordant cells during micro-mass differentiation of embryonic stem cells into the chondrocyte lineage.
Cell death and differentiation
Yamashita A,Krawetz R,Rancourt DE
Sun Feb 01 00:00:00 UTC 2009
TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation.
Oncogene
Fleming YM,Ferguson GJ,Spender LC,Larsson J,Karlsson S,Ozanne BW,Grosse R,Inman GJ
Thu Feb 19 00:00:00 UTC 2009
A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate.
Oncogene
Bhattacharyya S,Ishida W,Wu M,Wilkes M,Mori Y,Hinchcliff M,Leof E,Varga J
Thu Mar 12 00:00:00 UTC 2009
TGFbeta1 antagonistic peptides inhibit TGFbeta1-dependent angiogenesis.
Biochemical pharmacology
Serratì S,Margheri F,Pucci M,Cantelmo AR,Cammarota R,Dotor J,Borràs-Cuesta F,Fibbi G,Albini A,Del Rosso M
100-21 was used in In vitro experiments to show that TGFbeta up-regulates expression not only of plasminogen activator inhibitor type-1 (PAI-1), but also of the urokinase-type plasminogen activator receptor (uPAR), whose inhibition by specific antibodies blunted the TGFbeta angiogenic response in vitro.
Sun Mar 01 00:00:00 UTC 2009
Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.
The American journal of pathology
Schissel SL,Dunsmore SE,Liu X,Shine RW,Perrella MA,Layne MD
Sun Mar 01 00:00:00 UTC 2009
T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Smith E,von Vietinghoff S,Stark MA,Zarbock A,Sanders JM,Duley A,Rivera-Nieves J,Bender TP,Ley K
Sun Nov 01 00:00:00 UTC 2009
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts.
Journal of immunology (Baltimore, Md. : 1950)
Nurieva R,Yang XO,Chung Y,Dong C
Sun Mar 01 00:00:00 UTC 2009
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Fiorina P,Jurewicz M,Augello A,Vergani A,Dada S,La Rosa S,Selig M,Godwin J,Law K,Placidi C,Smith RN,Capella C,Rodig S,Adra CN,Atkinson M,Sayegh MH,Abdi R
Wed Jul 15 00:00:00 UTC 2009
Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Li Z,Mao K,Zou J,Wang Y,Tao Z,Lin G,Tian L,Ji Y,Wu X,Zhu X,Sun S,Chen W,Xiang C,Sun B
Sun Nov 15 00:00:00 UTC 2009
IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sharma R,Sung SS,Abaya CE,Ju AC,Fu SM,Ju ST
Wed Jul 15 00:00:00 UTC 2009
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
Journal of immunology (Baltimore, Md. : 1950)
Gondek DC,Roan NR,Starnbach MN
Wed Jul 15 00:00:00 UTC 2009
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kohlhaas S,Garden OA,Scudamore C,Turner M,Okkenhaug K,Vigorito E
Sun Mar 01 00:00:00 UTC 2009
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950)
Totsuka T,Kanai T,Nemoto Y,Tomita T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Akiba H,Okumura K,Yagita H,Watanabe M
Fri May 15 00:00:00 UTC 2009
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Canonigo-Balancio AJ,Fos C,Prod'homme T,Bécart S,Altman A
Tue Dec 01 00:00:00 UTC 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
Sun Mar 01 00:00:00 UTC 2009
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Oyamada A,Ikebe H,Itsumi M,Saiwai H,Okada S,Shimoda K,Iwakura Y,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H
Tue Dec 01 00:00:00 UTC 2009
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.
Journal of immunology (Baltimore, Md. : 1950)
Lahl K,Mayer CT,Bopp T,Huehn J,Loddenkemper C,Eberl G,Wirnsberger G,Dornmair K,Geffers R,Schmitt E,Buer J,Sparwasser T
Sun Nov 01 00:00:00 UTC 2009
A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Newcomb DC,Zhou W,Moore ML,Goleniewska K,Hershey GK,Kolls JK,Peebles RS
Fri May 01 00:00:00 UTC 2009
IL-17A controls IL-17F production and maintains blood neutrophil counts in mice.
Journal of immunology (Baltimore, Md. : 1950)
von Vietinghoff S,Ley K
Wed Jul 15 00:00:00 UTC 2009
Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Griffiths MR,Neal JW,Fontaine M,Das T,Gasque P
Wed Apr 01 00:00:00 UTC 2009
IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M
Thu Jan 15 00:00:00 UTC 2009
Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.
Journal of immunology (Baltimore, Md. : 1950)
Vincent-Fabert C,Truffinet V,Fiancette R,Cogné N,Cogné M,Denizot Y
Mon Jun 01 00:00:00 UTC 2009
Development of serum-free, chemically defined conditions for human embryonic stem cell-derived fibrochondrogenesis.
Tissue engineering. Part A
Koay EJ,Athanasiou KA
Sat Aug 01 00:00:00 UTC 2009
Umbilical cord Wharton's Jelly: a new potential cell source of mesenchymal stromal cells for bone tissue engineering.
Tissue engineering. Part A
Hou T,Xu J,Wu X,Xie Z,Luo F,Zhang Z,Zeng L
Tue Sep 01 00:00:00 UTC 2009
A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering.
Tissue engineering. Part A
Wang L,Tran I,Seshareddy K,Weiss ML,Detamore MS
Sat Aug 01 00:00:00 UTC 2009
Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells.
Tissue engineering. Part A
Kothapalli CR,Taylor PM,Smolenski RT,Yacoub MH,Ramamurthi A
Sun Mar 01 00:00:00 UTC 2009
Production of hyaline-like cartilage by bone marrow mesenchymal stem cells in a self-assembly model.
Tissue engineering. Part A
Elder SH,Cooley AJ,Borazjani A,Sowell BL,To H,Tran SC
Thu Oct 01 00:00:00 UTC 2009
Recruitment of a host's osteoprogenitor cells using exogenous mesenchymal stem cells seeded on porous ceramic.
Tissue engineering. Part A
Tasso R,Augello A,Boccardo S,Salvi S,Caridà M,Postiglione F,Fais F,Truini M,Cancedda R,Pennesi G
Sat Aug 01 00:00:00 UTC 2009
Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds.
Tissue engineering. Part A
Diao H,Wang J,Shen C,Xia S,Guo T,Dong L,Zhang C,Chen J,Zhao J,Zhang J
Tue Sep 01 00:00:00 UTC 2009
Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix.
Tissue engineering. Part A
Syed-Picard FN,Larkin LM,Shaw CM,Arruda EM
Thu Jan 01 00:00:00 UTC 2009
Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells.
Differentiation; research in biological diversity
Ke H,Wang P,Yu W,Liu X,Liu C,Yang F,Mao FF,Zhang L,Zhang X,Lahn BT,Xiang AP
Sun Mar 01 00:00:00 UTC 2009
The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.
The Journal of biological chemistry
Band AM,Björklund M,Laiho M
Fri Dec 18 00:00:00 UTC 2009
Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim.
The Journal of biological chemistry
Houde N,Chamoux E,Bisson M,Roux S
Fri Aug 28 00:00:00 UTC 2009
TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1.
The Journal of biological chemistry
Spender LC,Inman GJ
Fri Jan 16 00:00:00 UTC 2009
Different domains regulate homomeric and heteromeric complex formation among type I and type II transforming growth factor-beta receptors.
The Journal of biological chemistry
Rechtman MM,Nakaryakov A,Shapira KE,Ehrlich M,Henis YI
Fri Mar 20 00:00:00 UTC 2009
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation.
The Journal of biological chemistry
Martinez GJ,Zhang Z,Chung Y,Reynolds JM,Lin X,Jetten AM,Feng XH,Dong C
Fri Dec 18 00:00:00 UTC 2009
The morphological and molecular features of the epithelial-to-mesenchymal transition.
Nature protocols
Moreno-Bueno G,Peinado H,Molina P,Olmeda D,Cubillo E,Santos V,Palacios J,Portillo F,Cano A
Wed Jan 06 00:00:00 UTC 2010
The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma.
PloS one
Bhattacharyya S,Wei J,Melichian DS,Milbrandt J,Takehara K,Varga J
Mon Oct 26 00:00:00 UTC 2009
Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver.
PloS one
Baertschiger RM,Serre-Beinier V,Morel P,Bosco D,Peyrou M,Clément S,Sgroi A,Kaelin A,Buhler LH,Gonelle-Gispert C
Mon Aug 17 00:00:00 UTC 2009
Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter.
The Journal of biological chemistry
Piscopo DM,Johansen EB,Derynck R
Fri Nov 13 00:00:00 UTC 2009
A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.
BMC cell biology
Herrera B,Inman GJ
Thu Mar 19 00:00:00 UTC 2009
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Molecular systems biology
Saez-Rodriguez J,Alexopoulos LG,Epperlein J,Samaga R,Lauffenburger DA,Klamt S,Sorger PK
Thu Apr 01 00:00:00 UTC 2010
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.
Immunity
Chen Q,Yang W,Gupta S,Biswas P,Smith P,Bhagat G,Pernis AB
Fri Dec 19 00:00:00 UTC 2008
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 UTC 2008
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.
The Journal of experimental medicine
Chong MM,Rasmussen JP,Rudensky AY,Littman DR
Mon Sep 01 00:00:00 UTC 2008
CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.
Proceedings of the National Academy of Sciences of the United States of America
Kim-Saijo M,Janssen EM,Sugie K
Tue Dec 09 00:00:00 UTC 2008
Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells.
Arthritis research & therapy
Nakai T,Mochida J,Sakai D
Mon Aug 03 00:00:00 UTC 2009
Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Tonkin DR,He J,Barbour G,Haskins K
Wed Oct 01 00:00:00 UTC 2008
B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
Journal of immunology (Baltimore, Md. : 1950)
Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S
Tue Jul 01 00:00:00 UTC 2008
CCR6 regulates the migration of inflammatory and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamazaki T,Yang XO,Chung Y,Fukunaga A,Nurieva R,Pappu B,Martin-Orozco N,Kang HS,Ma L,Panopoulos AD,Craig S,Watowich SS,Jetten AM,Tian Q,Dong C
Mon Dec 15 00:00:00 UTC 2008
IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu E,Kawahara K,Kajizono M,Sawada M,Nakayama H
Sat Nov 01 00:00:00 UTC 2008
Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Duan W,So T,Croft M
Mon Dec 15 00:00:00 UTC 2008
IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Hu Y,Hu X,Boumsell L,Ivashkiv LB
Sun Jun 15 00:00:00 UTC 2008
Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells.
BMC cell biology
Kretlow JD,Jin YQ,Liu W,Zhang WJ,Hong TH,Zhou G,Baggett LS,Mikos AG,Cao Y
Tue Oct 28 00:00:00 UTC 2008
Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
PloS one
Rodríguez-Vita J,Sánchez-Galán E,Santamaría B,Sánchez-López E,Rodrigues-Díez R,Blanco-Colio LM,Egido J,Ortiz A,Ruiz-Ortega M
Wed Mar 04 00:00:00 UTC 2009
Influence of olfactory epithelium on mitral/tufted cell dendritic outgrowth.
PloS one
Tran H,Chen H,Walz A,Posthumus JC,Gong Q
Wed Feb 04 00:00:00 UTC 2009
Activin A induces Langerhans cell differentiation in vitro and in human skin explants.
PloS one
Musso T,Scutera S,Vermi W,Daniele R,Fornaro M,Castagnoli C,Alotto D,Ravanini M,Cambieri I,Salogni L,Elia AR,Giovarelli M,Facchetti F,Girolomoni G,Sozzani S
Wed Sep 24 00:00:00 UTC 2008
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.
The Journal of biological chemistry
Thuault S,Tan EJ,Peinado H,Cano A,Heldin CH,Moustakas A
Fri Nov 28 00:00:00 UTC 2008
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
PloS one
Bauler TJ,Hendriks WJ,King PD
Thu Feb 19 00:00:00 UTC 2009
FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Ekoff M,Strasser A,Nilsson G
Sun Apr 01 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
P-glycoprotein expression in extracellular matrix formation of chondrogenic differentiation of human adult stem cells.
Cell biology international
Kim SG,Jeon CH,Suh HS,Choe JY,Shin IH
Sat Sep 01 00:00:00 UTC 2007
Runx3 regulates dendritic epidermal T cell development.
Developmental biology
Woolf E,Brenner O,Goldenberg D,Levanon D,Groner Y
Thu Mar 15 00:00:00 UTC 2007
ATP-induced proliferation of developing retinal cells: regulation by factors released from postmitotic cells in culture.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
França GR,Freitas RC,Ventura AL
Wed Aug 01 00:00:00 UTC 2007
Production of a novel fibroblast-populated platelet matrix cocultured with keratinocytes.
Tissue engineering
Schuster KM,Martens M,Goldenberg M,Tai C,Strande L,Hewitt CW
Sun Jul 01 00:00:00 UTC 2007
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.
The Journal of biological chemistry
Rydziel S,Stadmeyer L,Zanotti S,Durant D,Smerdel-Ramoya A,Canalis E
Fri Jul 06 00:00:00 UTC 2007
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature
Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ
Thu Aug 31 00:00:00 UTC 2006
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 UTC 2006
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 UTC 2006
Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia.
Journal of immunology (Baltimore, Md. : 1950)
Yang MS,Ji KA,Jeon SB,Jin BK,Kim SU,Jou I,Joe E
Sat Jul 15 00:00:00 UTC 2006
Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin-producing fibroblasts.
American journal of physiology. Renal physiology
Plotkin MD,Goligorsky MS
Sun Oct 01 00:00:00 UTC 2006
Skin-derived micro-organs induce angiogenesis in rabbits.
Journal of vascular research
Hasson E,Gallula J,Shimoni Y,Grad-Itach E,Marikovsky M,Mitrani E
Thu Mar 16 00:00:00 UTC 2006
Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.
The Journal of biological chemistry
Wiater E,Harrison CA,Lewis KA,Gray PC,Vale WW
Fri Jun 23 00:00:00 UTC 2006
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 UTC 2000
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 UTC 2000
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Blood
Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA
Sun Nov 15 00:00:00 UTC 1998
