Product References
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.
Nature
Arias AA,Neehus AL,Ogishi M,Meynier V,Krebs A,Lazarov T,Lee AM,Arango-Franco CA,Yang R,Orrego J,Corcini Berndt M,Rojas J,Li H,Rinchai D,Erazo-Borrás L,Han JE,Pillay B,Ponsin K,Chaldebas M,Philippot Q,Bohlen J,Rosain J,Le Voyer T,Janotte T,Amarajeeva K,Soudée C,Brollo M,Wiegmann K,Marquant Q,Seeleuthner Y,Lee D,Lainé C,Kloos D,Bailey R,Bastard P,Keating N,Rapaport F,Khan T,Moncada-Vélez M,Carmona MC,Obando C,Alvarez J,Cataño JC,Martínez-Rosado LL,Sanchez JP,Tejada-Giraldo M,L'Honneur AS,Agudelo ML,Perez-Zapata LJ,Arboleda DM,Alzate JF,Cabarcas F,Zuluaga A,Pelham SJ,Ensser A,Schmidt M,Velásquez-Lopera MM,Jouanguy E,Puel A,Krönke M,Ghirardello S,Borghesi A,Pahari S,Boisson B,Pittaluga S,Ma CS,Emile JF,Notarangelo LD,Tangye SG,Marr N,Lachmann N,Salvator H,Schlesinger LS,Zhang P,Glickman MS,Nathan CF,Geissmann F,Abel L,Franco JL,Bustamante J,Casanova JL,Boisson-Dupuis S
300-01A was used in In vitro experiments to report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant.
Sun Sep 01 00:00:00 UTC 2024
Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Cell reports. Medicine
Albanese M,Chen HR,Gapp M,Muenchhoff M,Yang HH,Peterhoff D,Hoffmann K,Xiao Q,Ruhle A,Ambiel I,Schneider S,Mejías-Pérez E,Stern M,Wratil PR,Hofmann K,Amann L,Jocham L,Fuchs T,Ulivi AF,Besson-Girard S,Weidlich S,Schneider J,Spinner CD,Sutter K,Dittmer U,Humpe A,Baumeister P,Wieser A,Rothenfusser S,Bogner J,Roider J,Knolle P,Hengel H,Wagner R,Laketa V,Fackler OT,Keppler OT
300-01A was used in Cell Culture to report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer.
Tue Apr 16 00:00:00 UTC 2024
Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.
iScience
Liu F,Lin Q,Shen S,Li Z,Xie X,Cheng Q,Wang L,Long Y,Wang J,Liu L
300-01A was used in In vitro experiments to design an extracellular matrix (ECM)-adhesion mimic hydrogel for intrauterine administration, which was more effective than direct injection in treating intrauterine adhesions.
Fri Jun 21 00:00:00 UTC 2024
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene
Clavaín L,Fernández-Pisonero I,Movilla N,Lorenzo-Martín LF,Nieto B,Abad A,García-Navas R,Llorente-González C,Sánchez-Martín M,Vicente-Manzanares M,Santos E,Alarcón B,García-Aznar JM,Dosil M,Bustelo XR
300-01A was used in In vitro experiments to indicate that gain-of-function mutations of R-RAS2/TC21 play roles in tumor initiation and maintenance that are not fully redundant with those regulated by classical RAS oncoproteins.
Sun Jan 01 00:00:00 UTC 2023
Early human lung immune cell development and its role in epithelial cell fate.
Science immunology
Barnes JL,Yoshida M,He P,Worlock KB,Lindeboom RGH,Suo C,Pett JP,Wilbrey-Clark A,Dann E,Mamanova L,Richardson L,Polanski K,Pennycuick A,Allen-Hyttinen J,Herczeg IT,Arzili R,Hynds RE,Teixeira VH,Haniffa M,Lim K,Sun D,Rawlins EL,Oliver AJ,Lyons PA,Marioni JC,Ruhrberg C,Tuong ZK,Clatworthy MR,Reading JL,Janes SM,Teichmann SA,Meyer KB,Nikolić MZ
300-01A was used in In vitro experiments to profile human embryonic and foetal lung immune cells using scRNA-seq, smFISH, and immunohistochemistry to find that IL-1β drives epithelial progenitor exit from self-renewal and differentiation to basal cells in vitro.
Fri Dec 15 00:00:00 UTC 2023
Detection of Free Bioactive IL-18 and IL-18BP in Inflammatory Disorders.
Methods in molecular biology (Clifton, N.J.)
Fauteux-Daniel S,Girard-Guyonvarc'h C,Caruso A,Rodriguez E,Gabay C
300-01A was used in In vitro experiments to measure mature, free, and bioactive interleukin (IL)-18 cytokine and IL-18-binding protein in different samples.
Mon Jun 26 00:00:00 UTC 2023
Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1.
EMBO reports
Grönloh MLB,Arts JJG,Palacios Martínez S,van der Veen AA,Kempers L,van Steen ACI,Roelofs JJTH,Nolte MA,Goedhart J,van Buul JD
300-01A was used in In vitro experiments to demonstrate that the 3 extracellular Ig-like domains of ICAM-1 are crucial for hotspot recognition.
Mon Jan 09 00:00:00 UTC 2023
A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2- Breast Cancer.
Cancers
Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Körner C,Ben-Baruch A
300-01A was used in Enzyme-linked immunosorbent assay to find regulatory roles for Y705-STAT3 and p65 in tumor microenvironment-stimulated HR+/HER2- tumors, with the ability to limit cancer stem cells enrichment.
Wed Apr 12 00:00:00 UTC 2023
TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.
The EMBO journal
Lin CP,Traets JJH,Vredevoogd DW,Visser NL,Peeper DS
300-01A was used in In vitro experiments to find a negative correlation between TSC2 expression and TRAIL signaling in TCGA patient cohorts.
Wed Mar 01 00:00:00 UTC 2023
Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.
Cell death & disease
Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M
300-01A was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.
Tue Apr 04 00:00:00 UTC 2023
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.
Science advances
Riera-Domingo C,Leite-Gomes E,Charatsidou I,Zhao P,Carrá G,Cappellesso F,Mourao L,De Schepper M,Liu D,Serneels J,Alameh MG,Shuvaev VV,Geukens T,Isnaldi E,Prenen H,Weissman D,Muzykantov VR,Soenen S,Desmedt C,Scheele CLGJ,Sablina A,Di Matteo M,Martín-Pérez R,Mazzone M
300-01A was used in In vitro experiments to find that ECs at the PMN coexpress tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5).
Wed Mar 22 00:00:00 UTC 2023
Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis.
Arthritis & rheumatology (Hoboken, N.J.)
Zhai Z,Yang F,Xu W,Han J,Luo G,Li Y,Zhuang J,Jie H,Li X,Shi X,Han X,Luo X,Song R,Chen Y,Liang J,Wu S,He Y,Sun E
Tue Mar 01 00:00:00 UTC 2022
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B.
Cellular and molecular life sciences : CMLS
Fettucciari K,Marguerie F,Fruganti A,Marchegiani A,Spaterna A,Brancorsini S,Marconi P,Bassotti G
300-01A was used in Sample Preparation (FC/FACS) to investigate effects of the virulence factors produced during Clostridioides difficile infection.
Fri Jul 22 00:00:00 UTC 2022
Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.
Oxidative medicine and cellular longevity
Li Y,Wu X,Li J,Du L,Wang X,Cao J,Li H,Huo Z,Li G,Pan D,Xu H,Xu B
Fri Mar 04 00:00:00 UTC 2022
Anti-apoptotic effects of human gingival mesenchymal stromal cells on polymorphonuclear leucocytes.
Oral diseases
Blufstein A,Behm C,Kubin B,Gahn J,Moritz A,Rausch-Fan X,Andrukhov O
Fri Apr 01 00:00:00 UTC 2022
NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells.
Biochemical and biophysical research communications
Makiyama K,Hazawa M,Kobayashi A,Lim K,Voon DC,Wong RW
Sat Jan 01 00:00:00 UTC 2022
Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.
Journal of clinical laboratory analysis
Xu W,Li S,Li M,Zhou H,Yang X
300-01A was used in Sample Preparation (FC/FACS) to investigate myeloid-derived suppressor cells in immunotherapy of cancer.
Sat Jan 01 00:00:00 UTC 2022
Beneficial effect of simvastatin on human umbilical vein endothelial cells gap junctions induced by TNF-α.
Animal cells and systems
Ling X,Peng S,Xu Y,Chu F
300-01A was used in Cell Culture to these marked changes indicated that simvastatin exerts its regulatory effects on gap junction function by upregulating Cx37 and Cx40 and downregulating Cx43 expression.
Tue Mar 22 00:00:00 UTC 2022
Tumor Necrosis Factor-α (TNFα) Stimulate Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a Xenograft Model.
Biology
Narasimhan H,Ferraro F,Bleilevens A,Weiskirchen R,Stickeler E,Maurer J
300-01A was used in Cell Culture to investigate mechanisms of cancer stem cells and their role in cancer progression.
Sun Oct 09 00:00:00 UTC 2022
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.
Nature communications
Yong L,Yu Y,Li B,Ge H,Zhen Q,Mao Y,Yu Y,Cao L,Zhang R,Li Z,Wang Y,Fan W,Zhang C,Wang D,Luo S,Bai Y,Chen S,Chen W,Liu M,Shen J,Sun L
300-01A was used in Cell Culture to investigate CaMK4 expression in psoriasis.
Fri Jul 22 00:00:00 UTC 2022
Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis.
Nutrients
Su M,Zhao W,Li Y,Li H,Xu S,Weng J
300-01A was used in In vitro experiments to reveal that PHACTR1 represents a new molecular target for RES to maintain endothelial cell homeostasis and prevent atherosclerotic cardiovascular disease.
Thu Oct 27 00:00:00 UTC 2022
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in immunology
Gopalakrishnan S,Hansen MD,Skovdahl HK,Roseth IA,van Beelen Granlund A,Østvik AE,Bakke I,Sandvik AK,Bruland T
300-01A was used in Cell Culture to identify a regulatory role for IBD-relevant pro-inflammatory signals on MHC-II expression that is influenced by Tofacitinib.
Mon Jun 06 00:00:00 UTC 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
300-01A was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 UTC 2022
Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells.
mBio
Zuniga M,Gomes C,Chen Z,Martinez C,Devlin JC,Loke P,Rodriguez A
300-01A was used in Sample Preparation (FC/FACS) to investigate TNF-α regulation of cerebral malaria infection across the blood-brain barrier.
Wed Oct 26 00:00:00 UTC 2022
Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.
Cancer medicine
Zhang S,Wang H,Liu Y,Tao T,Zeng Z,Zhou Y,Wang M
300-01A was used in Cell Culture to suggest that Nr-CWS can promote apoptosis of cervical carcinoma cells by enhancing the antitumor effect of dendritic cells and macrophages.
Tue Mar 01 00:00:00 UTC 2022
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Communications biology
Luke CJ,Markovina S,Good M,Wight IE,Thomas BJ,Linneman JM,Lanik WE,Koroleva O,Coffman MR,Miedel MT,Gong Q,Andress A,Campos Guerrero M,Wang S,Chen L,Beatty WL,Hausmann KN,White FV,Fitzpatrick JAJ,Orvedahl A,Pak SC,Silverman GA
Wed Jan 12 00:00:00 UTC 2022
Tracking the immune response by MRI using biodegradable and ultrasensitive microprobes.
Science advances
Martinez de Lizarrondo S,Jacqmarcq C,Naveau M,Navarro-Oviedo M,Pedron S,Adam A,Freis B,Allouche S,Goux D,Razafindrakoto S,Gazeau F,Mertz D,Vivien D,Bonnard T,Gauberti M
300-01A was used in Cell Culture to synthesize a contrast agent for molecular MRI based on a previously unknown mechanism of self-assembly of catechol-coated magnetite nanocrystals into microsized matrix-based particles, to make biodegradable microprobes that could carry up to 40,000 times higher amounts of superparamagnetic material than classically used nanoparticles while preserving favorable biocompatibility and excellent water dispersibility.
Fri Jul 15 00:00:00 UTC 2022
Dynamic regulation of myofibroblast phenotype in cellular senescence.
Aging cell
López-Antona I,Contreras-Jurado C,Luque-Martín L,Carpintero-Leyva A,González-Méndez P,Palmero I
300-01A was used in In vitro experiments to study the impact of senescence on the regulation of cell plasticity, focusing on the regulation of the myofibroblastic phenotype in primary fibroblasts.
Fri Apr 01 00:00:00 UTC 2022
Dynamic regulation of myofibroblast phenotype in cellular senescence.
Aging cell
López-Antona I,Contreras-Jurado C,Luque-Martín L,Carpintero-Leyva A,González-Méndez P,Palmero I
300-01A was used in In vitro experiments to study the impact of senescence on the regulation of cell plasticity, focusing on the regulation of the myofibroblastic phenotype in primary fibroblasts.
Fri Apr 01 00:00:00 UTC 2022
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
EMBO reports
Zhang R,Xue T,Shao A,Lang Y,Qin C,Zhao M,Kuang Y,Yu Z,Geng Y,Zhao C,Tang J
300-01A was used in Sample Preparation (FC/FACS) to suggest Bclaf1 is a key regulator in TNF-induced apoptosis, both in vitro and in vivo.
Wed Jan 05 00:00:00 UTC 2022
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
Cardiovascular research
Dolmatova EV,Forrester SJ,Wang K,Ou Z,Williams HC,Joseph G,Kumar S,Valdivia A,Kowalczyk AP,Qu H,Jo H,Lassègue B,Hernandes MS,Griendling KK
300-01A was used in Cell Culture to show that heterozygous deletion of polymerase δ-interacting protein 2 (Poldip2) was protective against sepsis-induced lung injury.
Wed Aug 24 00:00:00 UTC 2022
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
Cardiovascular research
Dolmatova EV,Forrester SJ,Wang K,Ou Z,Williams HC,Joseph G,Kumar S,Valdivia A,Kowalczyk AP,Qu H,Jo H,Lassègue B,Hernandes MS,Griendling KK
300-01A was used in Cell Culture to show that heterozygous deletion of polymerase δ-interacting protein 2 (Poldip2) was protective against sepsis-induced lung injury.
Wed Aug 24 00:00:00 UTC 2022
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release.
Frontiers in immunology
Yap JMG,Ueda T,Kanemitsu Y,Takeda N,Fukumitsu K,Fukuda S,Uemura T,Tajiri T,Ohkubo H,Maeno K,Ito Y,Oguri T,Ugawa S,Niimi A
300-01A was used in Cell Culture to investigate lung fibroblast memory following inflammatory episodes in chronic respiratory disease and COVID-19.
Wed Aug 10 00:00:00 UTC 2022
Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging.
Hepatology communications
Hernandez JC,Yeh DW,Marh J,Choi HY,Kim J,Chopra S,Ding L,Thornton M,Grubbs B,Makowka L,Sher L,Machida K
Fri Jul 01 00:00:00 UTC 2022
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis.
Drug design, development and therapy
Chen GY,Luo J,Liu Y,Yu XB,Liu XY,Tao QW
300-01A was used in Cell Culture to indicate that the treatment of RA with TFRD is closely related to inhibiting Th17 differentiation and inflammatory response of synoviocytes.
Thu Jun 16 00:00:00 UTC 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
300-01A was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 UTC 2022
Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation.
Frontiers in immunology
Atene CG,Fiorcari S,Mesini N,Alboni S,Martinelli S,Maccaferri M,Leonardi G,Potenza L,Luppi M,Maffei R,Marasca R
300-01A was used in In vitro experiments to study the functional role of the IDO1/Kyn/AHR axis in chronic lymphocytic leukemia (CLL).
Fri Apr 08 00:00:00 UTC 2022
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity.
Nature communications
Munasinghe TS,Edwards MR,Tsimbalyuk S,Vogel OA,Smith KM,Stewart M,Foster JK,Bosence LA,Aragão D,Roby JA,Basler CF,Forwood JK
300-01A was used in In vitro experiments to provide a detailed structural basis that explains how a virus can target the IMPα nuclear import adapter to impair immunity, and illustrate how small mutations in ORF4b, like those found in closely related coronaviruses such as HKU5, change the IMPα binding mechanism.
Fri Mar 25 00:00:00 UTC 2022
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Cancer discovery
Fonteneau G,Redding A,Hoag-Lee H,Sim ES,Heinrich S,Gaida MM,Grabocka E
300-01A was used in In vitro experiments to show that stress adaptation via the phase-separation organelles stress granules (SGs) mediates pancreatic ductal adenocarcinoma (PDAC) development.
Fri Aug 05 00:00:00 UTC 2022
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
300-01A was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 UTC 2022
The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
Communications biology
Machino H,Kaneko S,Komatsu M,Ikawa N,Asada K,Nakato R,Shozu K,Dozen A,Sone K,Yoshida H,Kato T,Oda K,Osuga Y,Fujii T,von Keudell G,Saloura V,Hamamoto R
Tue Jan 11 00:00:00 UTC 2022
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells.
Cell reports. Medicine
Li H,Liu Z,Liu L,Zhang H,Han C,Girard L,Park H,Zhang A,Dong C,Ye J,Rayford A,Peyton M,Li X,Avila K,Cao X,Hu S,Alam MM,Akbay EA,Solis LM,Behrens C,Hernandez-Ruiz S,Lu W,Wistuba I,Heymach JV,Chisamore M,Micklem D,Gabra H,Gausdal G,Lorens JB,Li B,Fu YX,Minna JD,Brekken RA
300-01A was used in Cell Culture to explore why mutations in STK11/LKB1 in non-small lung cancer are associated with poor patient responses to immune checkpoint blockade and introduction of Stk11/Lkb1 mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 loss resulted in an ICB refractory syngeneic KPL tumour.
Tue Mar 15 00:00:00 UTC 2022
Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer.
Cancers
Baram T,Oren N,Erlichman N,Meshel T,Ben-Baruch A
300-01A was used in In vitro experiments to suggest that in addition to its immune-suppressive activities, PD-L1 may promote disease course in TNBC by inhibiting the protective effects of sTNFR1 and sTNFR2.
Tue Jul 19 00:00:00 UTC 2022
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
Cell
Taft J,Markson M,Legarda D,Patel R,Chan M,Malle L,Richardson A,Gruber C,Martín-Fernández M,Mancini GMS,van Laar JAM,van Pelt P,Buta S,Wokke BHA,Sabli IKD,Sancho-Shimizu V,Chavan PP,Schnappauf O,Khubchandani R,Cüceoğlu MK,Özen S,Kastner DL,Ting AT,Aksentijevich I,Hollink IHIM,Bogunovic D
Thu Aug 19 00:00:00 UTC 2021
Spatially organized multicellular immune hubs in human colorectal cancer.
Cell
Pelka K,Hofree M,Chen JH,Sarkizova S,Pirl JD,Jorgji V,Bejnood A,Dionne D,Ge WH,Xu KH,Chao SX,Zollinger DR,Lieb DJ,Reeves JW,Fuhrman CA,Hoang ML,Delorey T,Nguyen LT,Waldman J,Klapholz M,Wakiro I,Cohen O,Albers J,Smillie CS,Cuoco MS,Wu J,Su MJ,Yeung J,Vijaykumar B,Magnuson AM,Asinovski N,Moll T,Goder-Reiser MN,Applebaum AS,Brais LK,DelloStritto LK,Denning SL,Phillips ST,Hill EK,Meehan JK,Frederick DT,Sharova T,Kanodia A,Todres EZ,Jané-Valbuena J,Biton M,Izar B,Lambden CD,Clancy TE,Bleday R,Melnitchouk N,Irani J,Kunitake H,Berger DL,Srivastava A,Hornick JL,Ogino S,Rotem A,Vigneau S,Johnson BE,Corcoran RB,Sharpe AH,Kuchroo VK,Ng K,Giannakis M,Nieman LT,Boland GM,Aguirre AJ,Anderson AC,Rozenblatt-Rosen O,Regev A,Hacohen N
Thu Sep 02 00:00:00 UTC 2021
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell
Mills RJ,Humphrey SJ,Fortuna PRJ,Lor M,Foster SR,Quaife-Ryan GA,Johnston RL,Dumenil T,Bishop C,Rudraraju R,Rawle DJ,Le T,Zhao W,Lee L,Mackenzie-Kludas C,Mehdiabadi NR,Halliday C,Gilham D,Fu L,Nicholls SJ,Johansson J,Sweeney M,Wong NCW,Kulikowski E,Sokolowski KA,Tse BWC,Devilée L,Voges HK,Reynolds LT,Krumeich S,Mathieson E,Abu-Bonsrah D,Karavendzas K,Griffen B,Titmarsh D,Elliott DA,McMahon J,Suhrbier A,Subbarao K,Porrello ER,Smyth MJ,Engwerda CR,MacDonald KPA,Bald T,James DE,Hudson JE
Thu Apr 15 00:00:00 UTC 2021
Recording of elapsed time and temporal information about biological events using Cas9.
Cell
Park J,Lim JM,Jung I,Heo SJ,Park J,Chang Y,Kim HK,Jung D,Yu JH,Min S,Yoon S,Cho SR,Park T,Kim HH
Thu Feb 18 00:00:00 UTC 2021
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.
Immunity
Lu Q,Liu J,Zhao S,Gomez Castro MF,Laurent-Rolle M,Dong J,Ran X,Damani-Yokota P,Tang H,Karakousi T,Son J,Kaczmarek ME,Zhang Z,Yeung ST,McCune BT,Chen RE,Tang F,Ren X,Chen X,Hsu JCC,Teplova M,Huang B,Deng H,Long Z,Mudianto T,Jin S,Lin P,Du J,Zang R,Su TT,Herrera A,Zhou M,Yan R,Cui J,Zhu J,Zhou Q,Wang T,Ma J,Koralov SB,Zhang Z,Aifantis I,Segal LN,Diamond MS,Khanna KM,Stapleford KA,Cresswell P,Liu Y,Ding S,Xie Q,Wang J
Tue Jun 08 00:00:00 UTC 2021
Environmental allergens trigger type 2 inflammation through ripoptosome activation.
Nature immunology
Brusilovsky M,Rochman M,Rochman Y,Caldwell JM,Mack LE,Felton JM,Habel JE,Porollo A,Pasare C,Rothenberg ME
Fri Oct 01 00:00:00 UTC 2021
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
Cell stem cell
Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD
300-01A was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
Thu Jan 07 00:00:00 UTC 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 UTC 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 UTC 2021
PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
The EMBO journal
Arif N,Zinnhardt M,Nyamay'Antu A,Teber D,Brückner R,Schaefer K,Li YT,Trappmann B,Grashoff C,Vestweber D
Mon May 03 00:00:00 UTC 2021
MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS.
Bone research
Fujii T,Murata K,Mun SH,Bae S,Lee YJ,Pannellini T,Kang K,Oliver D,Park-Min KH,Ivashkiv LB
Mon Jan 11 00:00:00 UTC 2021
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Chen Y,Li Y,Huang F,Luo B,Yuan Y,Xia B,Ma X,Yang T,Yu F,Liu J,Liu B,Song Z,Chen J,Yan S,Wu L,Pan T,Zhang X,Li R,Huang W,He X,Xiao F,Zhang J,Zhang H
Tue Jun 08 00:00:00 UTC 2021
TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization.
Proceedings of the National Academy of Sciences of the United States of America
López-Pérez W,Sai K,Sakamachi Y,Parsons C,Kathariou S,Ninomiya-Tsuji J
Tue Jun 22 00:00:00 UTC 2021
Gliding motility of Plasmodium merozoites.
Proceedings of the National Academy of Sciences of the United States of America
Yahata K,Hart MN,Davies H,Asada M,Wassmer SC,Templeton TJ,Treeck M,Moon RW,Kaneko O
Tue Nov 30 00:00:00 UTC 2021
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Proceedings of the National Academy of Sciences of the United States of America
Molinar-Inglis O,Birch CA,Nicholas D,Orduña-Castillo L,Cisneros-Aguirre M,Patwardhan A,Chen B,Grimsey NJ,Coronel LJ,Lin H,Gomez Menzies PK,Lawson MA,Patel HH,Trejo J
Tue Dec 07 00:00:00 UTC 2021
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Cell death and differentiation
Koschel J,Nishanth G,Just S,Harit K,Kröger A,Deckert M,Naumann M,Schlüter D
Thu Jul 01 00:00:00 UTC 2021
Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization.
Cellular and molecular life sciences : CMLS
Ke Y,Lv X,Fu X,Zhang J,Bohio AA,Zeng X,Hao W,Wang R,Boldogh I,Ba X
300-01A was used in Cell Culture to investigate the role of inflammation in regulating proteins and miRISC.
Mon Feb 01 00:00:00 UTC 2021
Promyelocytic leukemia protein targets MK2 to promote cytotoxicity.
EMBO reports
Chen IT,Chen HC,Lo YH,Lai PY,Hsieh FY,Wu YH,Shih HM,Lai MZ
Mon Dec 06 00:00:00 UTC 2021
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Oncogene
Lindzen M,Ghosh S,Noronha A,Drago D,Nataraj NB,Leitner O,Carvalho S,Zmora E,Sapoznik S,Shany KB,Levanon K,Aderka D,Ramírez BS,Dahlhoff M,McNeish I,Yarden Y
Sat May 01 00:00:00 UTC 2021
TNF-α Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway.
Oxidative medicine and cellular longevity
Chen D,Chen C,Xiao X,Huang Z,Huang X,Yao W
Fri Mar 04 00:00:00 UTC 2022
HO-1/CO Maintains Intestinal Barrier Integrity through NF-κB/MLCK Pathway in Intestinal HO-1-/- Mice.
Oxidative medicine and cellular longevity
Zhang Z,Zhang L,Zhang Q,Liu B,Li F,Xin Y,Duan Z
Tue Dec 28 00:00:00 UTC 2021
Mangiferin Alleviates Mitochondrial ROS in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration via Suppression of NF-κB Signaling Pathway.
Oxidative medicine and cellular longevity
Yu H,Hou G,Cao J,Yin Y,Zhao Y,Cheng L
Tue Dec 28 00:00:00 UTC 2021
Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression.
Oxidative medicine and cellular longevity
Sun J,Zhou M,Lv G,Li W,Liu Y,Liang J,Zhang J,Zhang S,Deng Y,Tao J
Fri Jan 28 00:00:00 UTC 2022
A novel role of MNT as a negative regulator of REL and the NF-κB pathway.
Oncogenesis
Liaño-Pons J,Lafita-Navarro MC,García-Gaipo L,Colomer C,Rodríguez J,von Kriegsheim A,Hurlin PJ,Ourique F,Delgado MD,Bigas A,Espinosa L,León J
Fri Jan 08 00:00:00 UTC 2021
A novel role of MNT as a negative regulator of REL and the NF-κB pathway.
Oncogenesis
Liaño-Pons J,Lafita-Navarro MC,García-Gaipo L,Colomer C,Rodríguez J,von Kriegsheim A,Hurlin PJ,Ourique F,Delgado MD,Bigas A,Espinosa L,León J
Fri Jan 08 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
300-01A was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.
Mon Feb 01 00:00:00 UTC 2021
Nuclear Dbf2-related Kinase 1 functions as tumor suppressor in glioblastoma by phosphorylation of Yes-associated protein.
Chinese medical journal
Chen B,Liu B,Yu T,Han YF,Wu C,Wang ZY
300-01A was used in Western Blotting to show that NDR1 functions as a tumor suppressor in glioblastoma (GBM).
Mon Aug 02 00:00:00 UTC 2021
Evidence-Based Network Modelling to Simulate Nucleus Pulposus Multicellular Activity in Different Nutritional and Pro-Inflammatory Environments.
Frontiers in bioengineering and biotechnology
Baumgartner L,Sadowska A,Tío L,González Ballester MA,Wuertz-Kozak K,Noailly J
300-01A was used in In vitro experiments to conclude that future work should focus on an amplification of the stimulus environment by integrating more key relevant stimuli, such as mechanical loading parameters, in order to better approximate native physiological environments.
Mon Aug 19 00:00:00 UTC 2024
Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.
Journal of leukocyte biology
Weinelt N,Karathanasis C,Smith S,Medler J,Malkusch S,Fulda S,Wajant H,Heilemann M,van Wijk SJL
Mon Feb 01 00:00:00 UTC 2021
Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.
Journal of leukocyte biology
Weinelt N,Karathanasis C,Smith S,Medler J,Malkusch S,Fulda S,Wajant H,Heilemann M,van Wijk SJL
Mon Feb 01 00:00:00 UTC 2021
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.
The American journal of pathology
O'Hare M,Amarnani D,Whitmore HAB,An M,Marino C,Ramos L,Delgado-Tirado S,Hu X,Chmielewska N,Chandrahas A,Fitzek A,Heinrich F,Steurer S,Ondruschka B,Glatzel M,Krasemann S,Sepulveda-Falla D,Lagares D,Pedron J,Bushweller JH,Liu P,Arboleda-Velasquez JF,Kim LA
Thu Jul 01 00:00:00 UTC 2021
Attenuation of canonical NF-κB signaling maintains function and stability of human Treg.
The FEBS journal
Ziegler LS,Gerner MC,Schmidt RLJ,Trapin D,Steinberger P,Pickl WF,Sillaber C,Egger G,Schwarzinger I,Schmetterer KG
Fri Jan 01 00:00:00 UTC 2021
Long Noncoding RNA EGOT Responds to Stress Signals to Regulate Cell Inflammation and Growth.
Journal of immunology (Baltimore, Md. : 1950)
Barriocanal M,Prior C,Suarez B,Unfried JP,Razquin N,Hervás-Stubbs S,Sangro B,Segura V,Fortes P
Thu Apr 15 00:00:00 UTC 2021
Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-κB Activation by Interacting with p65.
Journal of immunology (Baltimore, Md. : 1950)
Li C,Zhang M,Guan X,Hu H,Fu M,Liu Y,Hu Q
Tue Jun 15 00:00:00 UTC 2021
Cell-Associated HIV Cross-Presentation by Plasmacytoid Dendritic Cells Is Potentiated by Noncognate CD8+ T Cell Preactivation.
Journal of immunology (Baltimore, Md. : 1950)
Isnard S,Hatton EX,Iannetta M,Guillerme JB,Hosmalin A
Thu Jul 01 00:00:00 UTC 2021
Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β.
Journal of immunology (Baltimore, Md. : 1950)
Allaeys I,Ribeiro de Vargas F,Bourgoin SG,Poubelle PE
Thu Apr 15 00:00:00 UTC 2021
Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway.
International journal of molecular medicine
Zhang W,Jia L,Zhao B,Xiong Y,Wang YN,Liang J,Xu X
300-01A was used in In vitro experiments to demonstrate that Quer reduces the impaired osteogenesis of hPDLSCs under TNF‚α‚induced inflammatory conditions by inhibiting the NF‚κB/NLRP3 inflammasome pathway.
Thu Apr 01 00:00:00 UTC 2021
Scaffold compound L971 exhibits anti-inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways.
Journal of cellular and molecular medicine
Li M,Yan Y,Zhang X,Zhang Y,Xu X,Zhang L,Lu L,Wang J,Zhang Y,Song Q,Zhao C
Thu Jul 01 00:00:00 UTC 2021
Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix.
Journal of cell science
van Steen ACI,Kempers L,Schoppmeyer R,Blokker M,Beebe DJ,Nolte MA,van Buul JD
300-01A was used in In vitro experiments to demonstrate analysis of the full leukocyte extravasation process in a single assay using 3D imaging of leukocyte extravasation in a vessel-on-a-chip.
Mon Nov 01 00:00:00 UTC 2021
Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.
Stem cells international
Lee Y,Park YS,Choi NY,Kim YI,Koh YG
Tue Jul 27 00:00:00 UTC 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 UTC 2021
Notch2 suppression mimicking changes in human pulmonary hypertension modulates Notch1 and promotes endothelial cell proliferation.
American journal of physiology. Heart and circulatory physiology
Sahoo S,Li Y,de Jesus D,Sembrat J,Rojas MM,Goncharova E,Cifuentes-Pagano E,Straub AC,Pagano PJ
Wed Sep 01 00:00:00 UTC 2021
Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin.
American journal of physiology. Heart and circulatory physiology
Park KS,Schecterson L,Gumbiner BM
Thu Apr 01 00:00:00 UTC 2021
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition.
American journal of physiology. Gastrointestinal and liver physiology
Her JY,Lee Y,Kim SJ,Heo G,Choo J,Kim Y,Howe C,Rhee SH,Yu HS,Chung HY,Pothoulakis C,Im E
Fri Jan 01 00:00:00 UTC 2021
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2).
Chinese medicine
Wang M,Li W,Cui W,Hao Y,Mi Y,Wang H,Hou Y,Jia Z
Mon Oct 18 00:00:00 UTC 2021
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2).
Chinese medicine
Wang M,Li W,Cui W,Hao Y,Mi Y,Wang H,Hou Y,Jia Z
Mon Oct 18 00:00:00 UTC 2021
Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell.
Mediators of inflammation
Tien PT,Lin CH,Chen CS,Chang CY,Ku H,Gan D,Tsai YY,Chen JJ,Lin HJ,Wan L
Thu Mar 31 00:00:00 UTC 2022
Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells.
Mediators of inflammation
Hosokawa Y,Hosokawa I,Ozaki K
Thu Mar 31 00:00:00 UTC 2022
The Migration of Human Follicular Dendritic Cell-Like Cell Is Facilitated by Matrix Metalloproteinase 3 Expression That Is Mediated through TNFα-ERK1/2-AP1 Signaling.
Journal of immunology research
Pak HK,Kim YW,Nam B,Lee AN,Roh J,Gil M,Liu C,Chung YS,Park CS
Wed Dec 15 00:00:00 UTC 2021
Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus.
Journal of immunology research
Satria RD,Huang TW,Jhan MK,Shen TJ,Tseng PC,Wang YT,Yang ZY,Hsing CH,Lin CF
Mon Dec 06 00:00:00 UTC 2021
Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions.
Genes and immunity
Law SPL,Gatt PN,Schibeci SD,McKay FC,Vucic S,Hart P,Byrne SN,Brown D,Stewart GJ,Liddle C,Parnell GP,Booth DR
Sun Aug 01 00:00:00 UTC 2021
LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B.
Annals of translational medicine
Pan S,Liu R,Wu X,Ma K,Luo W,Nie K,Zhang C,Meng X,Tong T,Chen X,Wang X,Deng M
300-01A was used in In vitro experiments to investigate the role and mechanisms of NEAT1 on the development of inflammatory bowel disease.
Sat May 01 00:00:00 UTC 2021
A high molecular weight hyaluronic acid biphasic dispersion as potential therapeutics for interstitial cystitis.
Journal of biomedical materials research. Part B, Applied biomaterials
Rooney PR,Kannala VK,Kotla NG,Benito A,Dupin D,Loinaz I,Quinlan LR,Rochev Y,Pandit A
300-01A was used in In vitro experiments to investigate the use of hyaluronic acid to treat interstitial cystitis.
Tue Jun 01 00:00:00 UTC 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 UTC 2021
Anti-citrullinated protein antibodies are associated with neutrophil extracellular trap formation in rheumatoid arthritis.
Journal of clinical laboratory analysis
Wu S,Peng W,Liang X,Wang W
Mon Mar 01 00:00:00 UTC 2021
Berberine Protects against TNF-α-Induced Injury of Human Umbilical Vein Endothelial Cells via the AMPK/NF-κB/YY1 Signaling Pathway.
Evidence-based complementary and alternative medicine : eCAM
Chen L,Fan XD,Qu H,Bai RN,Shi DZ
Tue Jan 11 00:00:00 UTC 2022
The influence of TNF-α on the expression profile of key enzymes of steroidogenesis in H295R cells.
Postepy dermatologii i alergologii
Grabarek B,Cholewa K,Lodowska J
300-01A was used in Sample Preparation (PCR) to show the impact of tumor necrosis factor-α (TNF-α) on the expression of the key genes encoding enzymes involved in adrenal steroidogenesis.
Tue Jun 01 00:00:00 UTC 2021
Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells.
British journal of pharmacology
Han JH,Heo KS,Myung CS
300-01A was used in In vitro experiments to provide new insights into the mechanism by which CIAPIN1 regulates vascular remodelling and suggest a novel therapeutic target for treating vascular proliferative diseases.
Mon Nov 01 00:00:00 UTC 2021
Biomimetic Anti-PD-1 Peptide-Loaded 2D FePSe3 Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Fang X,Wu X,Li Z,Jiang L,Lo WS,Chen G,Gu Y,Wong WT
Fri Jan 01 00:00:00 UTC 2021
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.
Nature communications
Wilhelm M,Zolg DP,Graber M,Gessulat S,Schmidt T,Schnatbaum K,Schwencke-Westphal C,Seifert P,de Andrade Krätzig N,Zerweck J,Knaute T,Bräunlein E,Samaras P,Lautenbacher L,Klaeger S,Wenschuh H,Rad R,Delanghe B,Huhmer A,Carr SA,Clauser KR,Krackhardt AM,Reimer U,Kuster B
Mon Jun 07 00:00:00 UTC 2021
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Cell death & disease
Woznicki JA,Saini N,Flood P,Rajaram S,Lee CM,Stamou P,Skowyra A,Bustamante-Garrido M,Regazzoni K,Crawford N,McDade SS,Longley DB,Aza-Blanc P,Shanahan F,Zulquernain SA,McCarthy J,Melgar S,McRae BL,Nally K
Thu Sep 23 00:00:00 UTC 2021
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Nature communications
Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M
Fri May 21 00:00:00 UTC 2021
Delanzomib, a Novel Proteasome Inhibitor, Combined With Adalimumab Drastically Ameliorates Collagen-Induced Arthritis in Rats by Improving and Prolonging the Anti-TNF-α Effect of Adalimumab.
Frontiers in pharmacology
Wang L,Liu L,Hong X,Liu D,Cheng Z
300-01A was used in Immuno-assay to investigate the ameliorating effect of delanzomib on collagen-induced arthritis (CIA) and to explore the pharmacodynamics and pharmacokinetics (PK) interactions between delanzomib and adalimumab.
Sun Oct 06 00:00:00 UTC 2024
Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide.
Scientific reports
Ueno T,Yamamoto Y,Kawasaki K
Wed Mar 24 00:00:00 UTC 2021
Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants.
Scientific reports
Seumen CHT,Tomasiunaite U,Legler DF,Hauck CR
Fri Dec 24 00:00:00 UTC 2021
Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome.
Cell reports
Qin Q,Shou J,Li M,Gu M,Meng Z,Xu P,Meng H,Wang X
Tue May 25 00:00:00 UTC 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 UTC 2021
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
eLife
Arts JJ,Mahlandt EK,Grönloh ML,Schimmel L,Noordstra I,Gordon E,van Steen AC,Tol S,Walzog B,van Rijssel J,Nolte MA,Postma M,Khuon S,Heddleston JM,Wait E,Chew TL,Winter M,Montanez E,Goedhart J,van Buul JD
300-01A was used in In vitro experiments to discover a new mechanism that uses local induced junctional membrane protrusions to facilitate/steer the leukocyte escape/exit from inflamed vessel walls.
Wed Aug 25 00:00:00 UTC 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
300-01A was used in Cell Culture to investigate BET as a target in cancer.
Wed Jul 21 00:00:00 UTC 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
300-01A was used in Cell Culture to investigate BET as a target in cancer.
Wed Jul 21 00:00:00 UTC 2021
Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu XL,Dong X,Yang SC,Lai X,Liu HJ,Gao Y,Feng HY,Zhu MH,Yuan Y,Lu Q,Lovell JF,Chen HZ,Fang C
Thu Apr 01 00:00:00 UTC 2021
ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes.
iScience
Ma M,Li H,Wang P,Yang W,Mi R,Zhuang J,Jiang Y,Lu Y,Shen X,Wu Y,Shen H
300-01A was used in Cell Culture to find that activating transcription factor 6 and fibroblast growth factor 2 levels were higher in SKG mice and in cartilage of pateints with ankylosing spondylitis-1.
Fri Jul 23 00:00:00 UTC 2021
Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer.
International journal of breast cancer
Ghimirey N,Steele C,Czerniecki BJ,Koski GK,Showalter LE
Tue May 04 00:00:00 UTC 2021
Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway.
Cell death & disease
Xing Y,Lin Y,Zhang Y,Hu J,Liu J,Tian Y,Zhao J,Chen W,Han B
Tue Oct 26 00:00:00 UTC 2021
Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis.
Frontiers in pharmacology
Feng Y,Mei L,Wang M,Huang Q,Huang R
300-01A was used in Cell Culture to investigate treatment of rheumatoid arthritis with 18β-GA and downstream signaling effects.
Fri Aug 13 00:00:00 UTC 2021
Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis.
Frontiers in pharmacology
Feng Y,Mei L,Wang M,Huang Q,Huang R
300-01A was used in Cell Culture to investigate treatment of rheumatoid arthritis with 18β-GA and downstream signaling effects.
Fri Aug 13 00:00:00 UTC 2021
Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.
The Journal of biological chemistry
Georgiev GA,Gh MS,Romano J,Dias Teixeira KL,Struble C,Ryan DS,Sia RK,Kitt JP,Harris JM,Hsu KL,Libby A,Odrich MG,Suárez T,McKown RL,Laurie GW
Tue Sep 14 00:00:00 UTC 2021
Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages.
Scientific reports
Anil SM,Shalev N,Vinayaka AC,Nadarajan S,Namdar D,Belausov E,Shoval I,Mani KA,Mechrez G,Koltai H
Thu Jan 14 00:00:00 UTC 2021
Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.
Cells
Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A
300-01A was used in Cell Culture to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.
Mon May 31 00:00:00 UTC 2021
Endothelial STING controls T cell transmigration in an IFNI-dependent manner.
JCI insight
Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P
300-01A was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.
Mon Aug 09 00:00:00 UTC 2021
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells.
Scientific reports
Giese AA,Babendreyer A,Krappen P,Gross A,Strnad P,Düsterhöft S,Ludwig A
Mon Dec 20 00:00:00 UTC 2021
Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression.
Translational psychiatry
Price JB,Yates CG,Morath BA,Van De Wakker SK,Yates NJ,Butters K,Frye MA,McGee SL,Tye SJ
Thu Nov 25 00:00:00 UTC 2021
The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination.
Communications biology
Offeddu GS,Hajal C,Foley CR,Wan Z,Ibrahim L,Coughlin MF,Kamm RD
Fri Feb 26 00:00:00 UTC 2021
The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination.
Communications biology
Offeddu GS,Hajal C,Foley CR,Wan Z,Ibrahim L,Coughlin MF,Kamm RD
Fri Feb 26 00:00:00 UTC 2021
Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.
Redox biology
Pescador N,Francisco V,Vázquez P,Esquinas EM,González-Páramos C,Valdecantos MP,García-Martínez I,Urrutia AA,Ruiz L,Escalona-Garrido C,Foretz M,Viollet B,Fernández-Moreno MÁ,Calle-Pascual AL,Obregón MJ,Aragonés J,Valverde ÁM
300-01A was used in Cell Culture to find the impact of metformin on macrophages by suppressing a HIF1α-dependent proinflammatory program is likely responsible for a secondary beneficial effect on insulin-mediated glucose uptake and β-adrenergic responses in brown adipocytes.
Tue Oct 19 00:00:00 UTC 2021
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer.
Cancer communications (London, England)
Yang S,He X,Zhao J,Wang D,Guo S,Gao T,Wang G,Jin C,Yan Z,Wang N,Wang Y,Zhao Y,Xing J,Huang Q
Sun Aug 01 00:00:00 UTC 2021
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.
Cell death & disease
Egea V,Kessenbrock K,Lawson D,Bartelt A,Weber C,Ries C
Thu May 20 00:00:00 UTC 2021
Mitochondrial Transplantation Modulates Inflammation and Apoptosis, Alleviating Tendinopathy Both In Vivo and In Vitro.
Antioxidants (Basel, Switzerland)
Lee JM,Hwang JW,Kim MJ,Jung SY,Kim KS,Ahn EH,Min K,Choi YS
300-01A was used in In vitro experiments to demonstrate the therapeutic effects of direct mitochondrial transplantation in tendinopathy.
Wed Apr 28 00:00:00 UTC 2021
Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis.
Frontiers in pharmacology
Wang S,Tang C,Zhao H,Shen P,Lin C,Zhu Y,Han D
300-01A was used in Cell Culture to study the therapeutic efficacy and pharmacological mechanisms of action of Si-Ni-San (SNS) against liver fibrosis which has potency against liver diseases.
Tue Nov 07 00:00:00 UTC 2023
Smac-mimetics reduce numbers and viability of human osteoclasts.
Cell death discovery
Moen IN,Westhrin M,Håland E,Haug M,Nonstad U,Klaharn M,Standal T,Starheim KK
Fri Feb 19 00:00:00 UTC 2021
Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling.
Cell reports
Okubo K,Brenner MD,Cullere X,Saggu G,Patchen ML,Bose N,Mihori S,Yuan Z,Lowell CA,Zhu C,Mayadas TN
Tue May 18 00:00:00 UTC 2021
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.
Scientific reports
Ait-Ammar A,Bellefroid M,Daouad F,Martinelli V,Van Assche J,Wallet C,Rodari A,De Rovere M,Fahrenkrog B,Schwartz C,Van Lint C,Gautier V,Rohr O
Fri Jan 29 00:00:00 UTC 2021
Necroptosis Underlies Neutrophilic Inflammation Associated with the Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
Journal of inflammation research
Xie Y,Li M,Chen K,Zhu H,Tang M,Zhou C,Zheng Y,Wen J,Han M,Zhang J,Zhao K,Xiao H,Li H
300-01A was used in Enzyme-linked immunosorbent assay to investigate necroptosis in chronic rhinosinusitis with nasal polyps.
Tue Apr 26 00:00:00 UTC 2022
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis.
Nature communications
Liu M,Cao S,He L,Gao J,Arab JP,Cui H,Xuan W,Gao Y,Sehrawat TS,Hamdan FH,Ventura-Cots M,Argemi J,Pomerantz WCK,Johnsen SA,Lee JH,Gao F,Ordog T,Mathurin P,Revzin A,Bataller R,Yan H,Shah VH
Tue Jul 27 00:00:00 UTC 2021
Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis.
iScience
Ebata T,Terkawi MA,Hamasaki M,Matsumae G,Onodera T,Aly MK,Yokota S,Alhasan H,Shimizu T,Takahashi D,Homan K,Kadoya K,Iwasaki N
Fri Jun 25 00:00:00 UTC 2021
Smac-mimetic enhances antitumor effect of standard chemotherapy in ovarian cancer models via Caspase 8-independent mechanism.
Cell death discovery
Hernandez LF,Dull AB,Korrapati S,Annunziata CM
Fri Jun 04 00:00:00 UTC 2021
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 UTC 2021
Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response.
Communications biology
Enchéry F,Dumont C,Iampietro M,Pelissier R,Aurine N,Bloyet LM,Carbonnelle C,Mathieu C,Journo C,Gerlier D,Horvat B
Tue Nov 16 00:00:00 UTC 2021
Identification of the Main Active Components and Mechanism of Wang Bi Tablet in Treating Rheumatoid Arthritis Based on Integrative Pharmacology.
Frontiers in pharmacology
Jiao Y,Xu J,Chen H,Guo Q,Deng X,Zhang T,Zhang J,Shi C,Wang P
300-01A was used in Sample Preparation (ELISA) to study the underlying mechanism of the Wang Bi tablet (WBT) for the treatment of rheumatoid arthritis (RA) to show that WBT may attenuate RA through the inflammation-immune regulation system.
Tue Jun 22 00:00:00 UTC 2021
Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.
Cancers
Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M
300-01A was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.
Sat May 22 00:00:00 UTC 2021
RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
Frontiers in immunology
Zeng J,Zhang Y,Zhang H,Zhang Y,Gao L,Tong X,Xie Y,Hu Q,Chen C,Ding S,Lu J
300-01A was used in Sample Preparation to study the specific mechanism leading to the abnormal biological behavior of keratinocytes and suggest that RPL22 regulates keratinocytes abnormal biological behavior and contributes to the development of psoriatic phenotypes.
Mon Dec 13 00:00:00 UTC 2021
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Cell death & disease
Zhang W,Yin G,Zhao H,Ling H,Xie Z,Xiao C,Chen Y,Lin Y,Jiang T,Jin S,Wang J,Yang X
Wed Jan 20 00:00:00 UTC 2021
Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.
PLoS neglected tropical diseases
Bedoui Y,Septembre-Malaterre A,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P
300-01A was used in Cell Culture to report novel histological and in vitro data arguing for a plausible role of a COX-2-mediated inflammatory response post-chikungunya virus (CHIKV).
Mon Feb 01 00:00:00 UTC 2021
Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth.
Scientific reports
Wang YJ,Downey MA,Choi S,Shoup TM,Elmaleh DR
Fri Nov 12 00:00:00 UTC 2021
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration.
Frontiers in pharmacology
Skovdahl HK,Gopalakrishnan S,Svendsen TD,Granlund AVB,Bakke I,Ginbot ZG,Thorsvik S,Flatberg A,Sporsheim B,Ostrop J,Mollnes TE,Sandvik AK,Bruland T
300-01A was used in In vitro experiments to indicate that an oxygen concentration similar to the in vivo epithelial cell environment is of essence in experimental pharmacology.
Tue Jun 01 00:00:00 UTC 2021
JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.
iScience
Jankowski J,Lee HK,Wilflingseder J,Hennighausen L
Fri Aug 20 00:00:00 UTC 2021
Decompression effects on bone healing in rat mandible osteomyelitis.
Scientific reports
Sodnom-Ish B,Eo MY,Oh JH,Seo MH,Yang HJ,Lee JH,Kim SM
Thu Jun 03 00:00:00 UTC 2021
Decompression effects on bone healing in rat mandible osteomyelitis.
Scientific reports
Sodnom-Ish B,Eo MY,Oh JH,Seo MH,Yang HJ,Lee JH,Kim SM
Thu Jun 03 00:00:00 UTC 2021
Senescence-associated hyper-activation to inflammatory stimuli in vitro.
Aging
Budamagunta V,Manohar-Sindhu S,Yang Y,He Y,Traktuev DO,Foster TC,Zhou D
300-01A was used in Cell Culture to suggest that SnCs may play an important role in the age-related increases in the susceptibility to developing an exacerbated inflammatory response and highlight the potential to use senotherapeutics to ameliorate the severity of various devastating inflammatory conditions in the elderly.
Tue Aug 10 00:00:00 UTC 2021
Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.
Scientific reports
Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH
Wed Sep 15 00:00:00 UTC 2021
Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.
Scientific reports
Crakes KR,Pires J,Quach N,Ellis-Reis RE,Greathouse R,Chittum KA,Steiner JM,Pesavento P,Marks SL,Dandekar S,Gilor C
Tue Jun 29 00:00:00 UTC 2021
Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy.
Cell reports
Roverato ND,Sailer C,Catone N,Aichem A,Stengel F,Groettrup M
Tue Mar 16 00:00:00 UTC 2021
MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade.
Scientific reports
Tanimura A,Nakazato A,Tanaka N
Wed Feb 17 00:00:00 UTC 2021
TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG.
Theranostics
Xu C,Wu J,Wu Y,Ren Z,Yao Y,Chen G,Fang EF,Noh JH,Liu YU,Wei L,Chen X,Sima J
300-01A was used in In vitro experiments to identify a finely controlled regulation of neuronal necroptosis in AD by coordinated TNF-α signaling, RIPK1/3 activity and autophagy machinery.
Mon Feb 07 00:00:00 UTC 2022
Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils.
Nature communications
Manriquez V,Nivoit P,Urbina T,Echenique-Rivera H,Melican K,Fernandez-Gerlinger MP,Flamant P,Schmitt T,Bruneval P,Obino D,Duménil G
Tue Jul 27 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 UTC 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 UTC 2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons
Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD
300-01A was used in Cell Culture to investigate correlations between cytokine expression and mortality.
Wed Jul 21 00:00:00 UTC 2021
MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.
Cell death & disease
Huang C,Zhong W,Ren X,Huang X,Li Z,Chen C,Jiang B,Chen Z,Jian X,Yang L,Liu X,Huang H,Shen C,Chen X,Dou X,Yu B
Tue Oct 19 00:00:00 UTC 2021
Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019.
Clinical & translational immunology
Metzemaekers M,Cambier S,Blanter M,Vandooren J,de Carvalho AC,Malengier-Devlies B,Vanderbeke L,Jacobs C,Coenen S,Martens E,Pörtner N,Vanbrabant L,Van Mol P,Van Herck Y,Van Aerde N,Hermans G,Gunst J,Borin A,Toledo N Pereira B,Dos Sp Gomes AB,Primon Muraro S,Fabiano de Souza G,S Farias A,Proenca-Modena JL,R Vinolo MA,Marques PE,Wouters C,Wauters E,Struyf S,Matthys P,Opdenakker G,Marques RE,Wauters J,Gouwy M,Proost P
Mon Apr 01 00:00:00 UTC 2024
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 UTC 2021
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains.
Cell reports
Elliott PR,Leske D,Wagstaff J,Schlicher L,Berridge G,Maslen S,Timmermann F,Ma B,Fischer R,Freund SMV,Komander D,Gyrd-Hansen M
Tue Oct 05 00:00:00 UTC 2021
Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn's disease by promoting intestinal inflammation.
Cell reports
Tan G,Huang C,Chen J,Chen B,Zhi F
Tue Jun 15 00:00:00 UTC 2021
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature
Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ
300-01A was used in In vitro experiments to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.
Tue Dec 01 00:00:00 UTC 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
Thu Apr 16 00:00:00 UTC 2020
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Immunity
Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H
300-01A was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.
Tue Dec 15 00:00:00 UTC 2020
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity.
Nature genetics
Kinker GS,Greenwald AC,Tal R,Orlova Z,Cuoco MS,McFarland JM,Warren A,Rodman C,Roth JA,Bender SA,Kumar B,Rocco JW,Fernandes PACM,Mader CC,Keren-Shaul H,Plotnikov A,Barr H,Tsherniak A,Rozenblatt-Rosen O,Krizhanovsky V,Puram SV,Regev A,Tirosh I
Sun Nov 01 00:00:00 UTC 2020
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation.
Signal transduction and targeted therapy
Li S,Zhang Y,Guan Z,Li H,Ye M,Chen X,Shen J,Zhou Y,Shi ZL,Zhou P,Peng K
300-01A was used in Sample Prep (WB) to report that SARS-CoV-2 infection activates caspase-8 to trigger cell apoptosis and inflammatory cytokine processing in the lung epithelial cells.
Fri Oct 09 00:00:00 UTC 2020
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation.
Signal transduction and targeted therapy
Li S,Zhang Y,Guan Z,Li H,Ye M,Chen X,Shen J,Zhou Y,Shi ZL,Zhou P,Peng K
300-01A was used in Sample Prep (WB) to report that SARS-CoV-2 infection activates caspase-8 to trigger cell apoptosis and inflammatory cytokine processing in the lung epithelial cells.
Fri Oct 09 00:00:00 UTC 2020
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Nature cell biology
Hou J,Zhao R,Xia W,Chang CW,You Y,Hsu JM,Nie L,Chen Y,Wang YC,Liu C,Wang WJ,Wu Y,Ke B,Hsu JL,Huang K,Ye Z,Yang Y,Xia X,Li Y,Li CW,Shao B,Tainer JA,Hung MC
300-01A was used in In vitro experiments to identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/caspase-8 mediates a non-canonical pyroptosis pathway in cancer cells, causing tumour necrosis.
Thu Oct 01 00:00:00 UTC 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 UTC 2020
Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.
Blood
Braun LJ,Stegmeyer RI,Schäfer K,Volkery S,Currie SM,Kempe B,Nottebaum AF,Vestweber D
Thu Jul 30 00:00:00 UTC 2020
Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.
The Journal of clinical investigation
Masoud AG,Lin J,Azad AK,Farhan MA,Fischer C,Zhu LF,Zhang H,Sis B,Kassiri Z,Moore RB,Kim D,Anderson CC,Vederas JC,Adam BA,Oudit GY,Murray AG
Thu Jan 02 00:00:00 UTC 2020
C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.
The Journal of clinical investigation
N'diaye M,Brauner S,Flytzani S,Kular L,Warnecke A,Adzemovic MZ,Piket E,Min JH,Edwards W,Mela F,Choi HY,Magg V,James T,Linden M,Reichardt HM,Daws MR,van Horssen J,Kockum I,Harris RA,Olsson T,Guerreiro-Cacais AO,Jagodic M
Mon Feb 03 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 UTC 2020
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- B and NF- B-mediated cellular FLICE-inhibitory protein.
Acta pharmaceutica Sinica. B
Yuan Z,Yuan Z,Hasnat M,Zhang H,Liang P,Sun L,Jiang Z,Zhang L
300-01A was used in In vitro experiments to study the role of lipopolysaccharide (LPS) in triptolide/LPS-induced hepatotoxicity and the mechanism by which triptolide induces liver hypersensitivity upon LPS stimulation.
Fri May 01 00:00:00 UTC 2020
A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- B and NF- B-mediated cellular FLICE-inhibitory protein.
Acta pharmaceutica Sinica. B
Yuan Z,Yuan Z,Hasnat M,Zhang H,Liang P,Sun L,Jiang Z,Zhang L
300-01A was used in In vitro experiments to study the role of lipopolysaccharide (LPS) in triptolide/LPS-induced hepatotoxicity and the mechanism by which triptolide induces liver hypersensitivity upon LPS stimulation.
Fri May 01 00:00:00 UTC 2020
Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.
The EMBO journal
Weiterer SS,Meier-Soelch J,Georgomanolis T,Mizi A,Beyerlein A,Weiser H,Brant L,Mayr-Buro C,Jurida L,Beuerlein K,Müller H,Weber A,Tenekeci U,Dittrich-Breiholz O,Bartkuhn M,Nist A,Stiewe T,van IJcken WF,Riedlinger T,Schmitz ML,Papantonis A,Kracht M
Thu Jan 02 00:00:00 UTC 2020
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
The EMBO journal
Fennell LM,Gomez Diaz C,Deszcz L,Kavirayani A,Hoffmann D,Yanagitani K,Schleiffer A,Mechtler K,Hagelkruys A,Penninger J,Ikeda F
300-01A was used in In vitro experiments to propose that site-specific ubiquitination of HOIP regulates a LUBAC-dependent switch between survival and apoptosis in TNF signaling.
Tue Dec 15 00:00:00 UTC 2020
AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy.
Journal of cachexia, sarcopenia and muscle
Abou-Samra M,Selvais CM,Boursereau R,Lecompte S,Noel L,Brichard SM
Wed Apr 01 00:00:00 UTC 2020
CRISPR-Cas13a Inhibits HIV-1 Infection.
Molecular therapy. Nucleic acids
Yin L,Zhao F,Sun H,Wang Z,Huang Y,Zhu W,Xu F,Mei S,Liu X,Zhang D,Wei L,Cen S,Hu S,Liang C,Guo F
300-01A was used in In vitro experiments to investigate CRISPR-Cas13a targeting of HIV.
Fri Sep 04 00:00:00 UTC 2020
Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis.
Clinical and translational medicine
Strack E,Rolfe PA,Fink AF,Bankov K,Schmid T,Solbach C,Savai R,Sha W,Pradel L,Hartmann S,Brüne B,Weigert A
Tue Dec 01 00:00:00 UTC 2020
The aryl hydrocarbon receptor promotes inflammation-induced dedifferentiation and systemic metastatic spread of melanoma cells.
International journal of cancer
Mengoni M,Braun AD,Gaffal E,Tüting T
Sun Nov 15 00:00:00 UTC 2020
Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data.
Immunology
Toufiq M,Roelands J,Alfaki M,Syed Ahamed Kabeer B,Saadaoui M,Lakshmanan AP,Bangarusamy DK,Murugesan S,Bedognetti D,Hendrickx W,Al Khodor S,Terranegra A,Rinchai D,Chaussabel D,Garand M
Tue Dec 01 00:00:00 UTC 2020
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Journal of lipid research
Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE
Wed Jan 01 00:00:00 UTC 2020
Human Milk Oligosaccharides Differently Modulate Goblet Cells Under Homeostatic, Proinflammatory Conditions and ER Stress.
Molecular nutrition & food research
Cheng L,Kong C,Walvoort MTC,Faas MM,de Vos P
Sun Mar 01 00:00:00 UTC 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 UTC 2020
Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inoue K,Hu X,Zhao B
Sat Feb 01 00:00:00 UTC 2020
Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tao Y,Yue M,Lv C,Yun X,Qiao S,Fang Y,Wei Z,Xia Y,Dai Y
Sat Feb 01 00:00:00 UTC 2020
Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Olivares-González L,Velasco S,Millán JM,Rodrigo R
Thu Oct 01 00:00:00 UTC 2020
Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wei L,Cao P,Xu C,Zhong H,Wang X,Bai M,Hu B,Wang R,Liu N,Tian Y,Chen H,Li J,Yuan W
Tue Dec 01 00:00:00 UTC 2020
Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang R,Xu C,Zhong H,Hu B,Wei L,Liu N,Zhang Y,Shi Q,Wang C,Qi M,Gu Y,Shen X,Tian Y,Liu Y,Cao P,Chen H,Yuan W
Sun Mar 01 00:00:00 UTC 2020
IRF-1 promotes renal fibrosis by downregulation of Klotho.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li Y,Liu Y,Huang Y,Yang K,Xiao T,Xiong J,Wang K,Liu C,He T,Yu Y,Han W,Wang Y,Bi X,Zhang J,Huang Y,Zhang B,Zhao J
Sun Mar 01 00:00:00 UTC 2020
TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu L,Wang W,Xie TH,Zou J,Nie X,Wang X,Zhang MY,Wang ZY,Gu S,Zhuang M,Tan J,Shen C,Dai Y,Yang X,Yao Y,Wei TT
Sun Mar 01 00:00:00 UTC 2020
TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Bellamri N,Viel R,Morzadec C,Lecureur V,Joannes A,de Latour B,Llamas-Gutierrez F,Wollin L,Jouneau S,Vernhet L
Fri May 01 00:00:00 UTC 2020
Effect of Ibrutinib on the IFN Response of Chronic Lymphocytic Leukemia Cells.
Journal of immunology (Baltimore, Md. : 1950)
Xia M,Luo TY,Shi Y,Wang G,Tsui H,Harari D,Spaner DE
Sun Nov 15 00:00:00 UTC 2020
Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses.
Journal of immunology (Baltimore, Md. : 1950)
Abu-Shah E,Trendel N,Kruger P,Nguyen J,Pettmann J,Kutuzov M,Dushek O
Tue Sep 15 00:00:00 UTC 2020
Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.
Journal of cellular and molecular medicine
Chiu CZ,Wang BW,Yu YJ,Shyu KG
Sat Feb 01 00:00:00 UTC 2020
The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis.
American journal of physiology. Gastrointestinal and liver physiology
Jørandli JW,Thorsvik S,Skovdahl HK,Kornfeld B,Sæterstad S,Gustafsson BI,Sandvik AK,van Beelen Granlund A
Tue Dec 01 00:00:00 UTC 2020
Early Adalimumab and Anti-Adalimumab Antibody Levels for Prediction of Primary Nonresponse in Ankylosing Spondylitis Patients.
Clinical and translational science
Ding X,Zhu R,Wu J,Xue L,Gu M,Miao L
Fri May 01 00:00:00 UTC 2020
Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms.
Oncology reports
Jin W,Gu C,Zhou L,Yang X,Gui M,Zhang J,Chen J,Dong X,Yuan Q,Shan L
300-01A was used in In vitro experiments to suggest that theabrownin (TB) may be a promising anti‚metastatic candidate for anti‚osteosarcoma therapy.
Tue Dec 01 00:00:00 UTC 2020
Biodistribution of andrographolide to assess the interior-exterior relationship between the lung and intestine using microPET.
Thoracic cancer
Zhang Q,Cui Q
Sun Nov 01 00:00:00 UTC 2020
Inhibition of thymic stromal lymphopoietin production to improve pruritus and quality of life in infants and children with atopic dermatitis.
Journal of cosmetic dermatology
Fitoussi J,Virassamynaïk S,Callejon S,Weber S,Collet E,Scalia J,Chavagnac-Bonneville M,Trompezinski S,Sayag M
Sat Aug 01 00:00:00 UTC 2020
Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus.
European journal of oral sciences
Schreurs O,Karatsaidis A,Balta MG,Grung B,Hals EKB,Schenck K
Sat Feb 01 00:00:00 UTC 2020
Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells.
Scientific reports
White EZ,Pennant NM,Carter JR,Hawsawi O,Odero-Marah V,Hinton CV
Mon Jul 27 00:00:00 UTC 2020
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Cell death & disease
Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC
Mon Mar 02 00:00:00 UTC 2020
UL16-Binding Protein 1 Induced HTR-8/SVneo Autophagy via NF-κB Suppression Mediated by TNF-α Secreted through uNK Cells.
BioMed research international
Liu J,Song G,Meng T,Zhao G
300-01A was used in Cell Culture to suggest that TNF-α regulates autophagic activity in HTR-8/SVneo via NF-κB supression - potential mechanism related to ULBP1 in preeclampsia pathogenesis.
Tue Mar 30 00:00:00 UTC 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Proceedings of the National Academy of Sciences of the United States of America
Scholz F,Grau M,Menzel L,Graband A,Zapukhlyak M,Leutz A,Janz M,Lenz G,Rehm A,Höpken UE
Tue Oct 20 00:00:00 UTC 2020
Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model.
Cell death & disease
Li J,Huang S,Zeng L,Li K,Yang L,Gao S,Guan C,Zhang S,Lao X,Liao G,Liang Y
Fri May 22 00:00:00 UTC 2020
Methods for Studying TNFα-Induced Autophagy.
Methods in molecular biology (Clifton, N.J.)
Najafi S,Abo-Ali EM,Dukhande VV
300-01A was used in In vitro experiments to discuss experimental techniques such as immunoblotting and fluorescence microscopy that can be utilized to measure autophagy in response to TNFα treatment.
Wed Jan 27 00:00:00 UTC 2021
Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation.
Scientific reports
Nakahara T,Kido-Nakahara M,Ulzii D,Miake S,Fujishima K,Sakai S,Chiba T,Tsuji G,Furue M
Thu Jun 11 00:00:00 UTC 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 UTC 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 UTC 2020
RNAi Screening Identifies that TEX10 Promotes the Proliferation of Colorectal Cancer Cells by Increasing NF-κB Activation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang Z,Sheng C,Kan G,Yao C,Geng R,Chen S
Tue Sep 01 00:00:00 UTC 2020
Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression.
International journal of molecular sciences
Pietrovito L,Iozzo M,Bacci M,Giannoni E,Chiarugi P
300-01A was used in In vitro experiments to show for the first time that cannabinoid treatment impairs the activation and the reactivity of cancer-associated fibroblasts (CAFs), the most represented stromal component of prostate tumor microenvironment.
Sat Jan 25 00:00:00 UTC 2020
Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.
The Journal of biological chemistry
Lim KS,Yong ZWE,Wang H,Tan TZ,Huang RY,Yamamoto D,Inaki N,Hazawa M,Wong RW,Oshima H,Oshima M,Ito Y,Voon DC
Fri May 08 00:00:00 UTC 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 UTC 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 UTC 2020
Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction.
Scientific reports
Bugueno IM,Zobairi El-Ghazouani F,Batool F,El Itawi H,Anglès-Cano E,Benkirane-Jessel N,Toti F,Huck O
Tue Feb 04 00:00:00 UTC 2020
Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.
Cell reports
Colomb F,Giron LB,Kuri-Cervantes L,Adeniji OS,Ma T,Dweep H,Battivelli E,Verdin E,Palmer CS,Tateno H,Kossenkov AV,Roan NR,Betts MR,Abdel-Mohsen M
300-01A was used in In vitro experiments to describe a glycomic feature of HIV-infected transcriptionally active cells that not only differentiates them from their transcriptionally inactive counterparts but also may affect their trafficking abilities.
Tue Aug 04 00:00:00 UTC 2020
hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts.
EBioMedicine
Todorova D,Zhang Y,Chen Q,Liu J,He J,Fu X,Xu Y
300-01A was used in Cell Culture to investigate whether the adoptive transfer of CTLA4-Ig/PD-L1 knock-in dendritic cell-like cells(CP DCLs) can induce long-term immune tolerance of parental human embryonic stem cells(hESC)-derived smooth muscle and cardiomyocyte allografts.
Tue Dec 01 00:00:00 UTC 2020
SIRT1 directly activates autophagy in human chondrocytes.
Cell death discovery
Sacitharan PK,Bou-Gharios G,Edwards JR
Tue Sep 26 00:00:00 UTC 2023
A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis.
Frontiers in immunology
Li Y,Mooney EC,Xia XJ,Gupta N,Sahingur SE
300-01A was used in Sample Preparation (WB) to characterize e role of A20 in human telomerase immortalized gingival keratinocytes (TIGKs) through loss and gain of function assays in preclinical models of periodontitis.
Mon Mar 15 00:00:00 UTC 2021
Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia.
Journal of the American Heart Association
Zhang S,Breidenbach JD,Khalaf FK,Dube PR,Mohammed CJ,Lad A,Stepkowski S,Hinds TD,Kumarasamy S,Kleinhenz A,Tian J,Malhotra D,Kennedy DJ,Cooper CJ,Haller ST
300-01A was used in Sample Preparation to suggest that activation of CD40 induces a significant proinflammatory and -fibrotic response and represents an attractive therapeutic target for treatment of ischemic renal disease.
Tue Apr 07 00:00:00 UTC 2020
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Cell death & disease
Woznicki JA,Flood P,Bustamante-Garrido M,Stamou P,Moloney G,Fanning A,Zulquernain SA,McCarthy J,Shanahan F,Melgar S,Nally K
Mon Jan 27 00:00:00 UTC 2020
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Cell death & disease
Woznicki JA,Flood P,Bustamante-Garrido M,Stamou P,Moloney G,Fanning A,Zulquernain SA,McCarthy J,Shanahan F,Melgar S,Nally K
Mon Jan 27 00:00:00 UTC 2020
Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.
Nature communications
Boshuizen J,Vredevoogd DW,Krijgsman O,Ligtenberg MA,Blankenstein S,de Bruijn B,Frederick DT,Kenski JCN,Parren M,Brüggemann M,Madu MF,Rozeman EA,Song JY,Horlings HM,Blank CU,van Akkooi ACJ,Flaherty KT,Boland GM,Peeper DS
Fri Aug 07 00:00:00 UTC 2020
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics.
Nature communications
Sadek J,Wuo MG,Rooklin D,Hauenstein A,Hong SH,Gautam A,Wu H,Zhang Y,Cesarman E,Arora PS
Tue Apr 14 00:00:00 UTC 2020
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
Scientific reports
Rom S,Heldt NA,Gajghate S,Seliga A,Reichenbach NL,Persidsky Y
Wed Apr 29 00:00:00 UTC 2020
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence.
Nature communications
Olan I,Parry AJ,Schoenfelder S,Narita M,Ito Y,Chan ASL,Slater GSC,Bihary D,Bando M,Shirahige K,Kimura H,Samarajiwa SA,Fraser P,Narita M
Fri Nov 27 00:00:00 UTC 2020
EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation.
Cell death & disease
Zhang T,Yang L,Ke Y,Lei J,Shen S,Shao S,Zhang C,Zhu Z,Dang E,Wang G
Sat Oct 03 00:00:00 UTC 2020
Phosphoregulated orthogonal signal transduction in mammalian cells.
Nature communications
Scheller L,Schmollack M,Bertschi A,Mansouri M,Saxena P,Fussenegger M
Thu Jun 18 00:00:00 UTC 2020
TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis.
Viruses
Mandal P,McCormick AL,Mocarski ES
300-01A was used in Cell Culture to conclude that caspase-8 suppression by vICA emerges as key to subverting innate immune elimination of a wide variety of infected cell types.
Wed Oct 28 00:00:00 UTC 2020
Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription.
Scientific reports
Shrestha A,Bruckmueller H,Kildalsen H,Kaur G,Gaestel M,Wetting HL,Mikkola I,Seternes OM
Thu Jul 09 00:00:00 UTC 2020
Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription.
Scientific reports
Shrestha A,Bruckmueller H,Kildalsen H,Kaur G,Gaestel M,Wetting HL,Mikkola I,Seternes OM
Thu Jul 09 00:00:00 UTC 2020
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Scientific reports
Ingvarsen SZ,Gårdsvoll H,van Putten S,Nørregaard KS,Krigslund O,Meilstrup JA,Tran C,Jürgensen HJ,Melander MC,Nielsen CH,Kjaer A,Bugge TH,Engelholm LH,Behrendt N
Thu Nov 05 00:00:00 UTC 2020
Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness.
eLife
Zhao Z,Zhang Z,Li J,Dong Q,Xiong J,Li Y,Lan M,Li G,Zhu B
300-01A was used in In vitro experiments to investigate the role of TNF-α in hypomethylation inheritance for NF-κB activation.
Fri Nov 06 00:00:00 UTC 2020
Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface.
Scientific reports
Woodward AM,Di Zazzo A,Bonini S,Argüeso P
Mon Feb 10 00:00:00 UTC 2020
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.
Nature communications
Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
300-01A was used in In vitro experiments to provide a potential strategy for targeting triple-negative breast cancer with the combination of Tenascin-C blockade and immune checkpoint inhibitors.
Thu Jul 30 00:00:00 UTC 2020
Nintedanib ameliorates animal model of dermatitis.
Scientific reports
Heo MJ,Lee C,Choi SY,Choi YM,An IS,Bae S,An S,Jung JH
Wed Mar 11 00:00:00 UTC 2020
The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation.
The Journal of biological chemistry
Boehm AN,Bialas J,Catone N,Sacristan-Reviriego A,van der Spuy J,Groettrup M,Aichem A
Fri Oct 16 00:00:00 UTC 2020
In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.
Cell death & disease
Miles MA,Hawkins CJ
Thu Aug 13 00:00:00 UTC 2020
Inhibition of BRD4 prevents proliferation and epithelial-mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis.
Cell death & disease
Tan YF,Wang M,Chen ZY,Wang L,Liu XH
Fri Apr 17 00:00:00 UTC 2020
Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation.
Science advances
Dou G,Tian R,Liu X,Yuan P,Ye Q,Liu J,Liu S,Zhou J,Deng Z,Chen X,Liu S,Jin Y
300-01A was used in Cell Culture to provides strategies to arbitrarily engineer modular EVs that integrate the advantages of natural EVs and synthetic materials for various applications.
Wed Jul 01 00:00:00 UTC 2020
Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation.
Cell death & disease
Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ
Mon May 04 00:00:00 UTC 2020
microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4.
Oncogenesis
Li Z,Zhou Y,Zhang L,Jia K,Wang S,Wang M,Li N,Yu Y,Cao X,Hou J
300-01A was used in In vitro experiments to identify and verified that hepatic programed cell death 4 (PDCD4), which promotes apoptosis, was directly targeted by miR-199a-3p.
Sat Oct 24 00:00:00 UTC 2020
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA.
Science advances
Wang K,Lin RZ,Hong X,Ng AH,Lee CN,Neumeyer J,Wang G,Wang X,Ma M,Pu WT,Church GM,Melero-Martin JM
300-01A was used in In vitro experiments to investigate human induced pluripotent stem cell-derived endothelial cells treatment.
Wed Jul 01 00:00:00 UTC 2020
ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.
Scientific reports
Oo JA,Irmer B,Günther S,Warwick T,Pálfi K,Izquierdo Ponce J,Teichmann T,Pflüger-Müller B,Gilsbach R,Brandes RP,Leisegang MS
Thu Nov 05 00:00:00 UTC 2020
Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures.
Scientific reports
Lowin T,Anssar TM,Bäuml M,Classen T,Schneider M,Pongratz G
Tue Jan 21 00:00:00 UTC 2020
Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.
Cells
Mandelli GE,Missale F,Bresciani D,Gatta LB,Scapini P,Caveggion E,Roca E,Bugatti M,Monti M,Cristinelli L,Belotti S,Simeone C,Calza S,Melocchi L,Vermi W
300-01A was used in In vitro experiments to explore the density and clinical significance of CD66b+ tumor-associated-neutrophils (TAN) and CD3+ T cells.
Sat Jan 25 00:00:00 UTC 2020
PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells.
The Journal of biological chemistry
Massa D,Baran M,Bengoechea JA,Bowie AG
Fri Apr 03 00:00:00 UTC 2020
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis.
Cell death & disease
Xu M,Tao J,Yang Y,Tan S,Liu H,Jiang J,Zheng F,Wu B
Mon Feb 03 00:00:00 UTC 2020
3D micro-organisation printing of mammalian cells to generate biological tissues.
Scientific reports
Jeffries GDM,Xu S,Lobovkina T,Kirejev V,Tusseau F,Gyllensten C,Singh AK,Karila P,Moll L,Orwar O
Tue Nov 10 00:00:00 UTC 2020
Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.
Cancers
Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L
300-01A was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.
Tue Oct 20 00:00:00 UTC 2020
Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming.
International journal of molecular sciences
Mazumdar A,Urdinez J,Boro A,Migliavacca J,Arlt MJE,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A
300-01A was used in Cell Culture to deliver foundational in vitro evidence that osteosarcoma cell-derived extracellular vesicles drive myofibroblast/cancer-associated fibroblast differentiation.
Thu Jul 30 00:00:00 UTC 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 UTC 2020
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis.
Nature communications
Beel S,Kolloch L,Apken LH,Jürgens L,Bolle A,Sudhof N,Ghosh S,Wardelmann E,Meisterernst M,Steinestel K,Oeckinghaus A
Wed Jul 08 00:00:00 UTC 2020
TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen M,Zhao Z,Meng Q,Liang P,Su Z,Wu Y,Huang J,Cui J
Wed Jan 01 00:00:00 UTC 2020
TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chen M,Zhao Z,Meng Q,Liang P,Su Z,Wu Y,Huang J,Cui J
Wed Jan 01 00:00:00 UTC 2020
Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming.
Nature communications
Krawczyk K,Scheller L,Kim H,Fussenegger M
Thu Jan 30 00:00:00 UTC 2020
ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface.
The Journal of biological chemistry
Yang J,LeBlanc ME,Cano I,Saez-Torres KL,Saint-Geniez M,Ng YS,D'Amore PA
Fri May 08 00:00:00 UTC 2020
EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer.
Nature cancer
Gong K,Guo G,Panchani N,Bender ME,Gerber DE,Minna JD,Fattah F,Gao B,Peyton M,Kernstine K,Mukherjee B,Burma S,Chiang CM,Zhang S,Amod Sathe A,Xing C,Dao KH,Zhao D,Akbay EA,Habib AA
300-01A was used in Sample Preparation (WB) to investigate EGFR inhibition in non-small cell lung carcinoma.
Wed Apr 01 00:00:00 UTC 2020
Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.
Cell
Vredevoogd DW,Kuilman T,Ligtenberg MA,Boshuizen J,Stecker KE,de Bruijn B,Krijgsman O,Huang X,Kenski JCN,Lacroix R,Mezzadra R,Gomez-Eerland R,Yildiz M,Dagidir I,Apriamashvili G,Zandhuis N,van der Noort V,Visser NL,Blank CU,Altelaar M,Schumacher TN,Peeper DS
Thu Jul 25 00:00:00 UTC 2019
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Cell
Huang B,Chen Z,Geng L,Wang J,Liang H,Cao Y,Chen H,Huang W,Su M,Wang H,Xu Y,Liu Y,Lu B,Xian H,Li H,Li H,Ren L,Xie J,Ye L,Wang H,Zhao J,Chen P,Zhang L,Zhao S,Zhang T,Xu B,Che D,Si W,Gu X,Zeng L,Wang Y,Li D,Zhan Y,Delfouneso D,Lew AM,Cui J,Tang WH,Zhang Y,Gong S,Bai F,Yang M,Zhang Y
Thu Nov 14 00:00:00 UTC 2019
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Immunity
Zhao Y,Lee CK,Lin CH,Gassen RB,Xu X,Huang Z,Xiao C,Bonorino C,Lu LF,Bui JD,Hui E
Tue Dec 17 00:00:00 UTC 2019
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Immunity
Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB
Tue Aug 20 00:00:00 UTC 2019
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation.
Cancer cell
Kim J,Yu L,Chen W,Xu Y,Wu M,Todorova D,Tang Q,Feng B,Jiang L,He J,Chen G,Fu X,Xu Y
Mon Feb 11 00:00:00 UTC 2019
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell
Gomes AP,Ilter D,Low V,Rosenzweig A,Shen ZJ,Schild T,Rivas MA,Er EE,McNally DR,Mutvei AP,Han J,Ou YH,Cavaliere P,Mullarky E,Nagiec M,Shin S,Yoon SO,Dephoure N,Massagué J,Melnick AM,Cantley LC,Tyler JK,Blenis J
Mon Oct 14 00:00:00 UTC 2019
Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese.
National science review
Zhang DF,Fan Y,Xu M,Wang G,Wang D,Li J,Kong LL,Zhou H,Luo R,Bi R,Wu Y,Li GD,Li M,Luo XJ,Jiang HY,Tan L,Zhong C,Fang Y,Zhang C,Sheng N,Jiang T,Yao YG
300-01A was used in Cell Culture to investigate the genome of Alzheimer's disease in Han Chinese patients.
Fri Mar 01 00:00:00 UTC 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 UTC 2019
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
The Journal of clinical investigation
Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC
Mon Jul 15 00:00:00 UTC 2019
Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.
Arthritis & rheumatology (Hoboken, N.J.)
Pringle S,Wang X,Verstappen GMPJ,Terpstra JH,Zhang CK,He A,Patel V,Jones RE,Baird DM,Spijkervet FKL,Vissink A,Bootsma H,Coppes RP,Kroese FGM
300-01A was used in In vitro experiments to investigate the role of salivary gland stem cells in hyposalivation in primary SS.
Tue Jan 01 00:00:00 UTC 2019
Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Huang M,Zhu S,Huang H,He J,Tsuji K,Jin WW,Xie D,Ham O,Capen DE,Lu W,Păunescu TG,Yang B,Lu HAJ
300-01A was used in In vitro experiments to investigate integrity-linked kinase involvement in necroptosis.
Fri Nov 01 00:00:00 UTC 2019
Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death.
The EMBO journal
Keuss MJ,Hjerpe R,Hsia O,Gourlay R,Burchmore R,Trost M,Kurz T
Fri Mar 15 00:00:00 UTC 2019
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.
Molecular psychiatry
Johnstone M,Vasistha NA,Barbu MC,Dando O,Burr K,Christopher E,Glen S,Robert C,Fetit R,Macleod KG,Livesey MR,Clair DS,Blackwood DHR,Millar K,Carragher NO,Hardingham GE,Wyllie DJA,Johnstone EC,Whalley HC,McIntosh AM,Lawrie SM,Chandran S
Fri Feb 01 00:00:00 UTC 2019
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
Leukemia
Velázquez-Avila M,Balandrán JC,Ramírez-Ramírez D,Velázquez-Avila M,Sandoval A,Felipe-López A,Nava P,Alvarado-Moreno JA,Dozal D,Prieto-Chávez JL,Schaks M,Rottner K,Dorantes-Acosta E,López-Martínez B,Schnoor M,Pelayo R
Sat Jun 01 00:00:00 UTC 2019
Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Proceedings of the National Academy of Sciences of the United States of America
Bianco C,Thompson L,Mohr I
Tue Nov 05 00:00:00 UTC 2019
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Proceedings of the National Academy of Sciences of the United States of America
Lu Y,Stuart JH,Talbot-Cooper C,Agrawal-Singh S,Huntly B,Smid AI,Snowden JS,Dupont L,Smith GL
Tue Jun 11 00:00:00 UTC 2019
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.
Proceedings of the National Academy of Sciences of the United States of America
Neidel S,Ren H,Torres AA,Smith GL
Tue Mar 19 00:00:00 UTC 2019
Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release.
Proceedings of the National Academy of Sciences of the United States of America
Göbel K,Asaridou CM,Merker M,Eichler S,Herrmann AM,Geuß E,Ruck T,Schüngel L,Groeneweg L,Narayanan V,Schneider-Hohendorf T,Gross CC,Wiendl H,Kehrel BE,Kleinschnitz C,Meuth SG
Wed Jan 02 00:00:00 UTC 2019
Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering.
Experimental & molecular medicine
Jang Y,Choi J,Park N,Kang J,Kim M,Kim Y,Ju JH
Mon Jan 07 00:00:00 UTC 2019
High-Throughput Assessment of Kinome-wide Activation States.
Cell systems
Schmidlin T,Debets DO,van Gelder CAGH,Stecker KE,Rontogianni S,van den Eshof BL,Kemper K,Lips EH,van den Biggelaar M,Peeper DS,Heck AJR,Altelaar M
300-01A was used in In vitro experiments to monitor the activation of 63 kinases through 73 T-loop phosphosites across different cell types, primary cells, and patient-derived tissue material.
Wed Oct 23 00:00:00 UTC 2019
GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.
Cell proliferation
Li L,Tang P,Zhou Z,Wang Q,Xu T,Zhao S,Huang Y,Kong F,Liu W,Cheng L,Zhou Z,Zhao X,Gu C,Luo Y,Tao G,Qian D,Chen J,Fan J,Yin G
Fri Nov 01 00:00:00 UTC 2019
TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium.
Mucosal immunology
Birkl D,Quiros M,García-Hernández V,Zhou DW,Brazil JC,Hilgarth R,Keeney J,Yulis M,Bruewer M,García AJ,O Leary MN,Parkos CA,Nusrat A
300-01A was used in In vitro experiments to show that TNFα promotes intestinal mucosal repair through upregulation of the GPCR platelet activating factor receptor (PAFR) in the intestinal epithelium.
Mon Jul 01 00:00:00 UTC 2019
Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production.
Glia
Kamermans A,Planting KE,Jalink K,van Horssen J,de Vries HE
Tue Jan 01 00:00:00 UTC 2019
Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.
Stem cells translational medicine
Chahal J,Gómez-Aristizábal A,Shestopaloff K,Bhatt S,Chaboureau A,Fazio A,Chisholm J,Weston A,Chiovitti J,Keating A,Kapoor M,Ogilvie-Harris DJ,Syed KA,Gandhi R,Mahomed NN,Marshall KW,Sussman MS,Naraghi AM,Viswanathan S
Thu Aug 01 00:00:00 UTC 2019
Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway.
Cancer science
Long J,Hu Z,Xue H,Wang Y,Chen J,Tang F,Zhou J,Liu L,Qiu W,Zhang S,Ouyang Y,Ye Y,Xu G,Li L,Zeng Z
Thu Aug 01 00:00:00 UTC 2019
Tumor necrosis factor receptor modulator spermatogenesis-associated protein 2 is a novel predictor of outcome in ovarian cancer.
Cancer science
Wieser V,Tsibulak I,Degasper C,Welponer H,Leitner K,Parson W,Zeimet AG,Marth C,Fiegl H
Fri Mar 01 00:00:00 UTC 2019
Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells.
Journal of leukocyte biology
Wisgrill L,Wessely I,Netzl A,Pummer L,Sadeghi K,Spittler A,Berger A,Förster-Waldl E
Fri Nov 01 00:00:00 UTC 2019
Targeted Migration of Human Adipose-Derived Stem Cells to Secondary Lymphoid Organs Enhances Their Immunomodulatory Effect and Prolongs the Survival of Allografted Vascularized Composites.
Stem cells (Dayton, Ohio)
Ma T,Luan S,Tao R,Lu D,Guo L,Liu J,Shu J,Zhou X,Han Y,Jia Y,Li G,Zhang H,Han W,Han Y,Li H
Sun Dec 01 00:00:00 UTC 2019
A High-Content Screening Approach to Identify MicroRNAs Against Head and Neck Cancer Cell Survival and EMT in an Inflammatory Microenvironment.
Frontiers in oncology
Sangiorgi B,de Souza FC,Mota de Souza Lima I,Dos Santos Schiavinato JL,Corveloni AC,Thomé CH,Araújo Silva W,Faça VM,Covas DT,Zago MA,Panepucci RA
300-01A was used in Sample Preparation (Western Blotting) to explore how microRNAs can affect cell survival and EMT in HNSCC cells under an inflammatory microenvironment.
Thu Oct 01 00:00:00 UTC 2020
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease).
Journal of cellular and molecular medicine
Xie Z,Kuhns DB,Gu X,Otu HH,Libermann TA,Gallin JI,Parikh SM,Druey KM
Thu Aug 01 00:00:00 UTC 2019
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Journal of cellular and molecular medicine
Tian L,Su CP,Wang Q,Wu FJ,Bai R,Zhang HM,Liu JY,Lu WJ,Wang W,Lan F,Guo SZ
Mon Jul 01 00:00:00 UTC 2019
Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
Journal of periodontal research
Janjić K,Schellner A,Engenhart A,Kernstock K,Schädl B,Moritz A,Agis H
Tue Oct 01 00:00:00 UTC 2019
Activity of two hyaluronan preparations on primary human oral fibroblasts.
Journal of periodontal research
Asparuhova MB,Kiryak D,Eliezer M,Mihov D,Sculean A
Fri Feb 01 00:00:00 UTC 2019
Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes.
Experimental and therapeutic medicine
Lee HS,Park JW,Kwon OK,Lim Y,Kim JH,Kim SY,Zamora N,Rosales K,Choi S,Oh SR,Ahn KS
300-01A was used in Sample Preparation (ELISA) to investigate the therapeutic effects of C. odorata L. methanol extract on TNF-α and IFN-γ-stimulated HaCaT keratinocyte cells.
Mon Jul 01 00:00:00 UTC 2019
Brucine inhibits TNF-α-induced HFLS-RA cell proliferation by activating the JNK signaling pathway.
Experimental and therapeutic medicine
Tang M,Zhu WJ,Yang ZC,He CS
300-01A was used in Sample Preparation to investigate effects of brucine on immunity in rheumatoid arthritis.
Mon Jul 01 00:00:00 UTC 2019
CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity.
Scientific reports
Majolée J,Pronk MCA,Jim KK,van Bezu JSM,van der Sar AM,Hordijk PL,Kovačević I
Fri May 31 00:00:00 UTC 2019
Umbilical cord as a long-term source of activatable mesenchymal stromal cells for immunomodulation.
Stem cell research & therapy
Selich A,Zimmermann K,Tenspolde M,Dittrich-Breiholz O,von Kaisenberg C,Schambach A,Rothe M
Mon Sep 23 00:00:00 UTC 2019
EMT is associated with an epigenetic signature of ECM remodeling genes.
Cell death & disease
Peixoto P,Etcheverry A,Aubry M,Missey A,Lachat C,Perrard J,Hendrick E,Delage-Mourroux R,Mosser J,Borg C,Feugeas JP,Herfs M,Boyer-Guittaut M,Hervouet E
Wed Feb 27 00:00:00 UTC 2019
Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF-Ang-Tie2 Signaling.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Haase K,Gillrie MR,Hajal C,Kamm RD
Sun Dec 01 00:00:00 UTC 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 UTC 2019
Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock.
Cell death & disease
Li C,Gu H,Yu M,Yang P,Zhang M,Ba H,Yin Y,Wang J,Yin B,Zhou X,Li Z
Mon Aug 05 00:00:00 UTC 2019
The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.
Scientific reports
Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW
Thu Jun 06 00:00:00 UTC 2019
Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators.
The Journal of biological chemistry
Sachdeva M,Duchateau P,Depil S,Poirot L,Valton J
Fri Apr 05 00:00:00 UTC 2019
(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Scientific reports
Guo S,Liu J,Jiang T,Lee D,Wang R,Zhou X,Jin Y,Shen Y,Wang Y,Bai F,Ding Q,Wang G,Zhang J,Zhou X,Schrodi SJ,He D
Thu Aug 01 00:00:00 UTC 2019
iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.
Nature communications
Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B
Fri Mar 22 00:00:00 UTC 2019
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.
Nature communications
Martínez-García JJ,Martínez-Banaclocha H,Angosto-Bazarra D,de Torre-Minguela C,Baroja-Mazo A,Alarcón-Vila C,Martínez-Alarcón L,Amores-Iniesta J,Martín-Sánchez F,Ercole GA,Martínez CM,González-Lisorge A,Fernández-Pacheco J,Martínez-Gil P,Adriouch S,Koch-Nolte F,Luján J,Acosta-Villegas F,Parrilla P,García-Palenciano C,Pelegrin P
Thu Jun 20 00:00:00 UTC 2019
A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells.
eLife
Abu-Shah E,Demetriou P,Bálint Š,Mayya V,Kutuzov MA,Dushek O,Dustin ML
300-01A was used in Cell Culture to report a tissue-like system that recapitulates the dynamics of engineered primary human immune cell and characterise unique dynamics of T-cell/DC interactions as a function of antigen affinity.
Wed Sep 25 00:00:00 UTC 2019
ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.
Cell death & disease
Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A
Mon Oct 07 00:00:00 UTC 2019
Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.
Frontiers in immunology
Liubomirski Y,Lerrer S,Meshel T,Rubinstein-Achiasaf L,Morein D,Wiemann S,Körner C,Ben-Baruch A
300-01A was used in Sample Preparation (ELISA) to study the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in triple-negative breast cancer (TNBC) to identify a novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.
Mon Aug 10 00:00:00 UTC 2020
Screening Analysis of Sirtuins Family Expression on Anti-Inflammation of Resveratrol in Endothelial Cells.
Medical science monitor : international medical journal of experimental and clinical research
Yu H,Pan W,Huang H,Chen J,Sun B,Yang L,Zhu P
300-01A was used in Cell Culture to study the role of sirtuin family members (SIRT1-SIRT7) on the anti-inflammation activities of resveratrol in endothelial cells.
Mon Jun 03 00:00:00 UTC 2019
The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1.
The Journal of biological chemistry
Bialas J,Boehm AN,Catone N,Aichem A,Groettrup M
Fri Mar 22 00:00:00 UTC 2019
Nanofiber-expanded human CD34+ cells heal cutaneous wounds in streptozotocin-induced diabetic mice.
Scientific reports
Kanji S,Das M,Joseph M,Aggarwal R,Sharma SM,Ostrowski M,Pompili VJ,Mao HQ,Das H
Mon Jun 10 00:00:00 UTC 2019
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.
Nature communications
Managò A,Audrito V,Mazzola F,Sorci L,Gaudino F,Gizzi K,Vitale N,Incarnato D,Minazzato G,Ianniello A,Varriale A,D'Auria S,Mengozzi G,Politano G,Oliviero S,Raffaelli N,Deaglio S
Wed Sep 11 00:00:00 UTC 2019
Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway.
Scientific reports
Lübbehüsen C,Lüke J,Seeling C,Mellert K,Marienfeld R,von Baer A,Schultheiss M,Möller P,Barth TFE
Tue Apr 23 00:00:00 UTC 2019
A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.
Scientific reports
Hacker K,Benke S,Agerer B,Scinicariello S,Budroni V,Versteeg GA
Mon May 27 00:00:00 UTC 2019
The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.
Scientific reports
Takino JI,Sato T,Nagamine K,Hori T
Wed Nov 13 00:00:00 UTC 2019
The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.
Scientific reports
Takino JI,Sato T,Nagamine K,Hori T
Wed Nov 13 00:00:00 UTC 2019
The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells.
Scientific reports
Takino JI,Sato T,Nagamine K,Hori T
Wed Nov 13 00:00:00 UTC 2019
The ubiquitin-like modifier FAT10 interferes with SUMO activation.
Nature communications
Aichem A,Sailer C,Ryu S,Catone N,Stankovic-Valentin N,Schmidtke G,Melchior F,Stengel F,Groettrup M
Tue Oct 01 00:00:00 UTC 2019
Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease.
Scientific reports
Dosh RH,Jordan-Mahy N,Sammon C,Le Maitre CL
Tue Feb 12 00:00:00 UTC 2019
Umbilical cord-derived mesenchymal stem cell extracts ameliorate atopic dermatitis in mice by reducing the T cell responses.
Scientific reports
Song JY,Kang HJ,Ju HM,Park A,Park H,Hong JS,Kim CJ,Shim JY,Yu J,Choi J
Mon Apr 29 00:00:00 UTC 2019
IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.
The Journal of biological chemistry
Magoro T,Dandekar A,Jennelle LT,Bajaj R,Lipkowitz G,Angelucci AR,Bessong PO,Hahn YS
Fri Oct 04 00:00:00 UTC 2019
An ultrasensitive fiveplex activity assay for cellular kinases.
Scientific reports
Smolko CM,Janes KA
Thu Dec 19 00:00:00 UTC 2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.
Nature metabolism
Chen PY,Qin L,Li G,Wang Z,Dahlman JE,Malagon-Lopez J,Gujja S,Cilfone NA,Kauffman KJ,Sun L,Sun H,Zhang X,Aryal B,Canfran-Duque A,Liu R,Kusters P,Sehgal A,Jiao Y,Anderson DG,Gulcher J,Fernandez-Hernando C,Lutgens E,Schwartz MA,Pober JS,Chittenden TW,Tellides G,Simons M
300-01A was used in In vivo experiments to show that the pro-inflammatory effects of endothelial TGFβ signaling differ to its effects in other cell types and show that it is an important driver of atherosclerotic plaque growth in atherosclerosis-associated vascular inflammation.
Sun Sep 01 00:00:00 UTC 2019
ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity.
The Journal of biological chemistry
Kelleher ZT,Wang C,Forrester MT,Foster MW,Marshall HE
Fri Sep 06 00:00:00 UTC 2019
Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation.
The Journal of biological chemistry
Kam A,Loo S,Fan JS,Sze SK,Yang D,Tam JP
Fri Dec 20 00:00:00 UTC 2019
NOD1 modulates decidual stromal cell function to maintain pregnancy in the early trimester.
Cell biochemistry and function
Zhang Y,Zhang Y,Li C,Fu S,Yang C,Song Y,Liu M,Wang Z,Liang P,Zhang J
300-01A was used in Cell Culture to indicate that RPL may be associated with NOD1 aberrant expression in DSCs, which plays a significant role in maintaining pregnancy via infection control and regulation of immune responses that might affect the pregnancy outcome.
Tue Oct 01 00:00:00 UTC 2019
Binding Immunoglobulin Protein (BIP) Inhibits TNF-α-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model.
ACR open rheumatology
Zaiss MM,Hall C,McGowan NWA,Babb R,Devlia V,Lucas S,Meghji S,Henderson B,Bozec A,Schett G,David JP,Panayi GS,Grigoriadis AE,Corrigall VM
Thu Aug 01 00:00:00 UTC 2019
Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles.
The Journal of biological chemistry
Ali M,Roback L,Mocarski ES
Fri Jan 18 00:00:00 UTC 2019
Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles.
The Journal of biological chemistry
Ali M,Roback L,Mocarski ES
Fri Jan 18 00:00:00 UTC 2019
Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.
Genome biology
Lalonde S,Codina-Fauteux VA,de Bellefon SM,Leblanc F,Beaudoin M,Simon MM,Dali R,Kwan T,Lo KS,Pastinen T,Lettre G
300-01A was used in Cell Culture to investigate the GWAS loci associated with coronary artery disease and blood pressure in endothelial cells.
Mon Jul 08 00:00:00 UTC 2019
Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication.
Scientific reports
Park MK,Cho H,Roh SW,Kim SJ,Myoung J
Wed Feb 20 00:00:00 UTC 2019
Functional characterization of iPSC-derived arterial- and venous-like endothelial cells.
Scientific reports
Rosa S,Praça C,Pitrez PR,Gouveia PJ,Aranguren XL,Ricotti L,Ferreira LS
Thu Mar 07 00:00:00 UTC 2019
Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.
Cell death & disease
Rocchio F,Tapella L,Manfredi M,Chisari M,Ronco F,Ruffinatti FA,Conte E,Canonico PL,Sortino MA,Grilli M,Marengo E,Genazzani AA,Lim D
300-01A was used in Sample Preparation (PCR) to present here immortalized hippocampal astrocytes from WT and 3xTg-AD mice that might be a useful model to speed up research on the role of astrocytes in AD.
Thu Jan 10 00:00:00 UTC 2019
A network-centric approach to drugging TNF-induced NF-κB signaling.
Nature communications
Pabon NA,Zhang Q,Cruz JA,Schipper DL,Camacho CJ,Lee REC
Tue Feb 26 00:00:00 UTC 2019
Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes.
Scientific reports
Riise R,Odqvist L,Mattsson J,Monkley S,Abdillahi SM,Tyrchan C,Muthas D,Yrlid LF
Tue Dec 31 00:00:00 UTC 2019
In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo.
International journal of pharmaceutics
Batool F,Agossa K,Lizambard M,Petit C,Bugueno IM,Delcourt-Debruyne E,Benkirane-Jessel N,Tenenbaum H,Siepmann J,Siepmann F,Huck O
300-01A was used in Enzyme-linked immunosorbent assay to indicate that chlorhexidine dihydrochloride-ibuprofen loaded in-situ forming implants could be efficient as adjuvant to periodontal therapy for the control of infection and inflammation.
Sat Oct 05 00:00:00 UTC 2019
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
Cell reports
Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A
300-01A was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.
Tue Aug 20 00:00:00 UTC 2019
The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation.
Scientific reports
Bang BR,Han KH,Seo GY,Croft M,Kang YJ
Thu Nov 28 00:00:00 UTC 2019
The proinflammatory cytokine TNFα induces DNA demethylation-dependent and -independent activation of interleukin-32 expression.
The Journal of biological chemistry
Zhao Z,Lan M,Li J,Dong Q,Li X,Liu B,Li G,Wang H,Zhang Z,Zhu B
Fri Apr 26 00:00:00 UTC 2019
Identification of stably expressed housekeeping miRNAs in endothelial cells and macrophages in an inflammatory setting.
Scientific reports
Link F,Krohn K,Schumann J
Wed Sep 04 00:00:00 UTC 2019
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Cell reports
Huang C,Hedl M,Ranjan K,Abraham C
300-01A was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.
Tue Dec 24 00:00:00 UTC 2019
Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.
Cell death discovery
da Hora CC,Pinkham K,Carvalho L,Zinter M,Tabet E,Nakano I,Tannous BA,Badr CE
Mon Sep 28 00:00:00 UTC 2020
Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures.
Scientific reports
Hernández Vera R,O'Callaghan P,Fatsis-Kavalopoulos N,Kreuger J
Mon Aug 05 00:00:00 UTC 2019
The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model.
Scientific reports
Kanehara K,Ohnuma S,Kanazawa Y,Sato K,Kokubo S,Suzuki H,Karasawa H,Suzuki T,Suzuki C,Naitoh T,Unno M,Abe T
Wed Sep 04 00:00:00 UTC 2019
TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.
Cell death & disease
Kim JE,Kim HJ,Jung JW,Song DG,Park D,Lee H,Um H,Park J,Nam SH,Cho M,Lee JW
Mon Sep 09 00:00:00 UTC 2019
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Nature communications
Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C
Tue Dec 10 00:00:00 UTC 2019
Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.
Scientific reports
Marzoq AJ,Mustafa SA,Heidrich L,Hoheisel JD,Alhamdani MSS
Thu Mar 28 00:00:00 UTC 2019
Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937.
International journal of tryptophan research : IJTR
Hoffmann D,Pilotte L,Stroobant V,Van den Eynde BJ
300-01A was used in Cell Culture to suggest that TDO might play an immunosuppressive role in human monocytic leukemias but not in untransformed macrophages.
Thu Oct 01 00:00:00 UTC 2020
HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway.
Cell death & disease
Aljabri A,Vijayan V,Stankov M,Nikolin C,Figueiredo C,Blasczyk R,Becker JU,Linkermann A,Immenschuh S
Fri Mar 08 00:00:00 UTC 2019
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer.
Nature
Calcinotto A,Spataro C,Zagato E,Di Mitri D,Gil V,Crespo M,De Bernardis G,Losa M,Mirenda M,Pasquini E,Rinaldi A,Sumanasuriya S,Lambros MB,Neeb A,Lucianò R,Bravi CA,Nava-Rodrigues D,Dolling D,Prayer-Galetti T,Ferreira A,Briganti A,Esposito A,Barry S,Yuan W,Sharp A,de Bono J,Alimonti A
300-01A was used in In vitro experiments to investigate the role of MDSCs-secreted IL-23 in prostate tumour cell formation.
Sun Jul 01 00:00:00 UTC 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 UTC 2018
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
Immunity
He W,Holtkamp S,Hergenhan SM,Kraus K,de Juan A,Weber J,Bradfield P,Grenier JMP,Pelletier J,Druzd D,Chen CS,Ince LM,Bierschenk S,Pick R,Sperandio M,Aurrand-Lions M,Scheiermann C
Tue Dec 18 00:00:00 UTC 2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
Mon Aug 13 00:00:00 UTC 2018
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.
Cancer cell
Tsoi J,Robert L,Paraiso K,Galvan C,Sheu KM,Lay J,Wong DJL,Atefi M,Shirazi R,Wang X,Braas D,Grasso CS,Palaskas N,Ribas A,Graeber TG
Mon May 14 00:00:00 UTC 2018
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
The Journal of clinical investigation
Gong K,Guo G,Gerber DE,Gao B,Peyton M,Huang C,Minna JD,Hatanpaa KJ,Kernstine K,Cai L,Xie Y,Zhu H,Fattah FJ,Zhang S,Takahashi M,Mukherjee B,Burma S,Dowell J,Dao K,Papadimitrakopoulou VA,Olivas V,Bivona TG,Zhao D,Habib AA
Fri Jun 01 00:00:00 UTC 2018
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.
Molecular cell
Zhao Y,Mudge MC,Soll JM,Rodrigues RB,Byrum AK,Schwarzkopf EA,Bradstreet TR,Gygi SP,Edelson BT,Mosammaparast N
300-01A was used in Sample Preparation (ELISA) to study how the deubiquitinase OTUD4, which nominally encodes a K48-specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63-specific deubiquitinase to show how deubiquitinase may modulate diverse processes through post-translational modification.
Thu Feb 01 00:00:00 UTC 2018
TNF-α induces human neural progenitor cell survival after oxygen-glucose deprivation by activating the NF-κB pathway.
Experimental & molecular medicine
Kim M,Jung K,Kim IS,Lee IS,Ko Y,Shin JE,Park KI
Fri Apr 06 00:00:00 UTC 2018
Resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates.
Experimental & molecular medicine
Wang YJ,Zhao P,Sui BD,Liu N,Hu CH,Chen J,Zheng CX,Liu AQ,Xuan K,Pan YP,Jin Y
Wed Jun 27 00:00:00 UTC 2018
Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration.
Experimental & molecular medicine
Wang H,He P,Pan H,Long J,Wang J,Li Z,Liu H,Jiang W,Zheng Z
Fri Apr 13 00:00:00 UTC 2018
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
Science signaling
Jones DS,Jenney AP,Joughin BA,Sorger PK,Lauffenburger DA
300-01A was used in In vitro experiments to investigate signaling pathways in rheumatoid arthritis.
Tue Mar 06 00:00:00 UTC 2018
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.
Cellular and molecular gastroenterology and hepatology
Wang Y,Kim R,Gunasekara DB,Reed MI,DiSalvo M,Nguyen DL,Bultman SJ,Sims CE,Magness ST,Allbritton NL
300-01A was used in In vitro experiments to show the in vitro human colon crypt array accurately mimicked the architecture, luminal accessibility, tissue polarity, cell migration, and cellular responses of in vivo intestinal crypts.
Mon Mar 18 00:00:00 UTC 2024
Multiple Autologous Bone Marrow-Derived CD271+ Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children.
Stem cells translational medicine
Milczarek O,Jarocha D,Starowicz-Filip A,Kwiatkowski S,Badyra B,Majka M
Mon Jan 01 00:00:00 UTC 2018
Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Xie JX,Zhang S,Cui X,Zhang J,Yu H,Khalaf FK,Malhotra D,Kennedy DJ,Shapiro JI,Tian J,Haller ST
300-01A was used in In vitro experiments to study the regulation of CD40 in the pathogenesis of renal injury and fibrosis.
Sun Jul 01 00:00:00 UTC 2018
Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.
Journal of lipid research
Newcomb B,Rhein C,Mileva I,Ahmad R,Clarke CJ,Snider J,Obeid LM,Hannun YA
Sun Jul 01 00:00:00 UTC 2018
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Journal of leukocyte biology
Kirchmeyer M,Servais FA,Hamdorf M,Nazarov PV,Ginolhac A,Halder R,Vallar L,Glanemann M,Rubie C,Lammert F,Kreis S,Behrmann I
Thu Nov 01 00:00:00 UTC 2018
Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation.
Journal of immunology (Baltimore, Md. : 1950)
Kroon J,Schaefer A,van Rijssel J,Hoogenboezem M,van Alphen F,Hordijk P,Stroes ESG,Strömblad S,van Rheenen J,van Buul JD
Thu Mar 01 00:00:00 UTC 2018
Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H
Thu Nov 15 00:00:00 UTC 2018
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G
Thu Mar 15 00:00:00 UTC 2018
BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.
Journal of cellular and molecular medicine
Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J
Thu Nov 01 00:00:00 UTC 2018
Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats.
Journal of cellular and molecular medicine
Wang J,Huang C,Lin Z,Pan X,Chen J,Zheng G,Tian N,Yan Y,Zhang Z,Hu J,Cheng P,Wang X,Zhang X
Thu Nov 01 00:00:00 UTC 2018
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.
Cell death & disease
Yue Y,Nabar NR,Shi CS,Kamenyeva O,Xiao X,Hwang IY,Wang M,Kehrl JH
Wed Sep 05 00:00:00 UTC 2018
Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog.
PloS one
Hadweh P,Chaitoglou I,Gravato-Nobre MJ,Ligoxygakis P,Mosialos G,Hatzivassiliou E
300-01A was used in In vitro experiments to demonstrate extensively overlapping functions between the HsCYLD and CeCYLD, which establish the C. elegans protein as a valuable model for the elucidation of the complex activity of the human tumor suppressor protein.
Wed Mar 14 00:00:00 UTC 2018
Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis.
Clinical and translational gastroenterology
Støy S,Sandahl TD,Hansen AL,Deleuran B,Vorup-Jensen T,Vilstrup H,Kragstrup TW
Fri Jun 15 00:00:00 UTC 2018
Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses.
PLoS neglected tropical diseases
Bedoui Y,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P
300-01A was used in In vitro experiments to argue for a beneficial effect of MTX to treat CIR post-CHIKV given that it does not critically impact the antiviral, the proinflammatory and the bone tissue remodeling responses of synovial cells.
Wed Aug 01 00:00:00 UTC 2018
The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.
Cell death & disease
Gu Y,Ding X,Huang J,Xue M,Zhang J,Wang Q,Yu H,Wang Y,Zhao F,Wang H,Jin M,Wu Y,Zhang Y
Tue May 01 00:00:00 UTC 2018
Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination.
Cell death & disease
Liu X,Li Y,Peng S,Yu X,Li W,Shi F,Luo X,Tang M,Tan Z,Bode AM,Cao Y
Fri Jan 19 00:00:00 UTC 2018
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.
mBio
Forte E,Swaminathan S,Schroeder MW,Kim JY,Terhune SS,Hummel M
300-01A was used in Sample Preparation (PCR) to study human cytomegalovirus (HCMV) latency and reactivation in myeloid progenitor cells to show that TNF-α induces reactivation independently of differentiation provides insight into molecular mechanisms that control reactivation.
Tue Sep 11 00:00:00 UTC 2018
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue.
The Journal of biological chemistry
Ballak DB,Li S,Cavalli G,Stahl JL,Tengesdal IW,van Diepen JA,Klück V,Swartzwelter B,Azam T,Tack CJ,Stienstra R,Mandrup-Poulsen T,Seals DR,Dinarello CA
Fri Sep 14 00:00:00 UTC 2018
The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis.
Scientific reports
Li HJ,Wu NL,Lee GA,Hung CF
Fri Apr 20 00:00:00 UTC 2018
Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells.
Scientific reports
Martin-Gallausiaux C,Béguet-Crespel F,Marinelli L,Jamet A,Ledue F,Blottière HM,Lapaque N
Wed Jun 27 00:00:00 UTC 2018
Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-α and IFN-γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models.
Scientific reports
Allen H,Shraga-Heled N,Blumenfeld M,Dego-Ashto T,Fuchs-Telem D,Gilert A,Aberman Z,Ofir R
Fri Jan 12 00:00:00 UTC 2018
The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.
The Journal of biological chemistry
Tang Y,Kwon H,Neel BA,Kasher-Meron M,Pessin JB,Yamada E,Pessin JE
Fri May 18 00:00:00 UTC 2018
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
Cell death & disease
Buchrieser J,Oliva-Martin MJ,Moore MD,Long JCD,Cowley SA,Perez-Simón JA,James W,Venero JL
Mon Sep 24 00:00:00 UTC 2018
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.
Cell death & disease
Yulis M,Quiros M,Hilgarth R,Parkos CA,Nusrat A
Fri Mar 09 00:00:00 UTC 2018
Primary Cilia Are Dysfunctional in Obese Adipose-Derived Mesenchymal Stem Cells.
Stem cell reports
Ritter A,Friemel A,Kreis NN,Hoock SC,Roth S,Kielland-Kaisen U,Brüggmann D,Solbach C,Louwen F,Yuan J
Tue Feb 13 00:00:00 UTC 2018
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Cell stem cell
Golan K,Kumari A,Kollet O,Khatib-Massalha E,Subramaniam MD,Ferreira ZS,Avemaria F,Rzeszotek S,García-García A,Xie S,Flores-Figueroa E,Gur-Cohen S,Itkin T,Ludin-Tal A,Massalha H,Bernshtein B,Ciechanowicz AK,Brandis A,Mehlman T,Bhattacharya S,Bertagna M,Cheng H,Petrovich-Kopitman E,Janus T,Kaushansky N,Cheng T,Sagi I,Ratajczak MZ,Méndez-Ferrer S,Dick JE,Markus RP,Lapidot T
300-01A was used in In vivo experiments to reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation.
Thu Oct 04 00:00:00 UTC 2018
Proteasome inhibition blocks necroptosis by attenuating death complex aggregation.
Cell death & disease
Ali M,Mocarski ES
Thu Mar 01 00:00:00 UTC 2018
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment.
Nature communications
Saggu G,Okubo K,Chen Y,Vattepu R,Tsuboi N,Rosetti F,Cullere X,Washburn N,Tahir S,Rosado AM,Holland SM,Anthony RM,Sen M,Zhu C,Mayadas TN
Thu Nov 29 00:00:00 UTC 2018
BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1.
Scientific reports
Gohda J,Suzuki K,Liu K,Xie X,Takeuchi H,Inoue JI,Kawaguchi Y,Ishida T
Fri Feb 23 00:00:00 UTC 2018
Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes.
Scientific reports
Domenis R,Cifù A,Quaglia S,Pistis C,Moretti M,Vicario A,Parodi PC,Fabris M,Niazi KR,Soon-Shiong P,Curcio F
Thu Sep 06 00:00:00 UTC 2018
Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice.
Microbiome
Pan F,Zhang L,Li M,Hu Y,Zeng B,Yuan H,Zhao L,Zhang C
300-01A was used in Cell Culture to study whether the modulated gut microbiota contributes to the attenuation of inflammation during calorie restriction (CR).
Wed Mar 21 00:00:00 UTC 2018
Regulation of IL-22BP in psoriasis.
Scientific reports
Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC
Fri Mar 23 00:00:00 UTC 2018
MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis.
Cell death & disease
Zhang W,Yi X,An Y,Guo S,Li S,Song P,Chang Y,Zhang S,Gao T,Wang G,Li C
Tue May 01 00:00:00 UTC 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Nature communications
Schubert M,Klinger B,Klünemann M,Sieber A,Uhlitz F,Sauer S,Garnett MJ,Blüthgen N,Saez-Rodriguez J
Tue Jan 02 00:00:00 UTC 2018
Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.
Scientific reports
Zardoya-Laguardia P,Blaschitz A,Hirschmugl B,Lang I,Herzog SA,Nikitina L,Gauster M,Häusler M,Cervar-Zivkovic M,Karpf E,Maghzal GJ,Stanley CP,Stocker R,Wadsack C,Frank S,Sedlmayr P
Tue Apr 03 00:00:00 UTC 2018
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
Cell reports
Kim C,Hu B,Jadhav RR,Jin J,Zhang H,Cavanagh MM,Akondy RS,Ahmed R,Weyand CM,Goronzy JJ
300-01A was used in In vitro experiments to suggest that curbing miR-21 upregulation or activity in older individuals may improve their ability to mount effective vaccine responses.
Tue Nov 20 00:00:00 UTC 2018
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.
Nature communications
Santos-Barriopedro I,Bosch-Presegué L,Marazuela-Duque A,de la Torre C,Colomer C,Vazquez BN,Fuhrmann T,Martínez-Pastor B,Lu W,Braun T,Bober E,Jenuwein T,Serrano L,Esteller M,Chen Z,Barceló-Batllori S,Mostoslavsky R,Espinosa L,Vaquero A
Tue Jan 09 00:00:00 UTC 2018
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.
Nature communications
Santos-Barriopedro I,Bosch-Presegué L,Marazuela-Duque A,de la Torre C,Colomer C,Vazquez BN,Fuhrmann T,Martínez-Pastor B,Lu W,Braun T,Bober E,Jenuwein T,Serrano L,Esteller M,Chen Z,Barceló-Batllori S,Mostoslavsky R,Espinosa L,Vaquero A
Tue Jan 09 00:00:00 UTC 2018
Beta-catenin cleavage enhances transcriptional activation.
Scientific reports
Goretsky T,Bradford EM,Ye Q,Lamping OF,Vanagunas T,Moyer MP,Keller PC,Sinh P,Llovet JM,Gao T,She QB,Li L,Barrett TA
Fri Jan 12 00:00:00 UTC 2018
Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration.
Cell death & disease
Gorth DJ,Shapiro IM,Risbud MV
Tue Dec 18 00:00:00 UTC 2018
Bone protection by inhibition of microRNA-182.
Nature communications
Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B
Fri Oct 05 00:00:00 UTC 2018
C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.
Scientific reports
Chen C,Wu N,Duan Q,Yang H,Wang X,Yang P,Zhang M,Liu J,Liu Z,Shao Y,Zheng Y
Tue Jun 05 00:00:00 UTC 2018
The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death.
Scientific reports
Merlo S,Spampinato SF,Beneventano M,Sortino MA
Tue May 08 00:00:00 UTC 2018
mGluR5 mediates post-radiotherapy fatigue development in cancer patients.
Translational psychiatry
Feng LR,Fernández-Martínez JL,Zaal KJM,deAndrés-Galiana EJ,Wolff BS,Saligan LN
Wed May 30 00:00:00 UTC 2018
Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.
Nature communications
Pircher J,Czermak T,Ehrlich A,Eberle C,Gaitzsch E,Margraf A,Grommes J,Saha P,Titova A,Ishikawa-Ankerhold H,Stark K,Petzold T,Stocker T,Weckbach LT,Novotny J,Sperandio M,Nieswandt B,Smith A,Mannell H,Walzog B,Horst D,Soehnlein O,Massberg S,Schulz C
Wed Apr 18 00:00:00 UTC 2018
Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha.
Scientific reports
Kawada S,Nagasawa Y,Kawabe M,Ohyama H,Kida A,Kato-Kogoe N,Nanami M,Hasuike Y,Kuragano T,Kishimoto H,Nakasho K,Nakanishi T
Fri Jan 12 00:00:00 UTC 2018
TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation.
Cell death & disease
Faletti L,Peintner L,Neumann S,Sandler S,Grabinger T,Mac Nelly S,Merfort I,Huang CH,Tschaharganeh D,Kang TW,Heinzmann F,D'Artista L,Maurer U,Brunner T,Lowe S,Zender L,Borner C
Wed Sep 05 00:00:00 UTC 2018
Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.
Scientific reports
Shinde P,Fernandes S,Melinkeri S,Kale V,Limaye L
Mon Apr 09 00:00:00 UTC 2018
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Cell
Gaidt MM,Ebert TS,Chauhan D,Ramshorn K,Pinci F,Zuber S,O'Duill F,Schmid-Burgk JL,Hoss F,Buhmann R,Wittmann G,Latz E,Subklewe M,Hornung V
Thu Nov 16 00:00:00 UTC 2017
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
Cell
Gong YN,Guy C,Olauson H,Becker JU,Yang M,Fitzgerald P,Linkermann A,Green DR
Thu Apr 06 00:00:00 UTC 2017
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.
The Journal of experimental medicine
Pierce RW,Merola J,Lavik JP,Kluger MS,Huttner A,Khokha MK,Pober JS
Mon Dec 04 00:00:00 UTC 2017
Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death.
Cell death and differentiation
Lim MCC,Maubach G,Sokolova O,Feige MH,Diezko R,Buchbinder J,Backert S,Schlüter D,Lavrik IN,Naumann M
Fri Sep 01 00:00:00 UTC 2017
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Cell systems
Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS
300-01A was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.
Wed Apr 26 00:00:00 UTC 2017
Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.
Aging cell
Suarez-Álvarez B,Rodríguez RM,Schlangen K,Raneros AB,Márquez-Kisinousky L,Fernández AF,Díaz-Corte C,Aransay AM,López-Larrea C
Sat Apr 01 00:00:00 UTC 2017
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology
Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E
Fri Sep 01 00:00:00 UTC 2017
Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice.
Journal of lipid research
Yang P,Xiao Y,Luo X,Zhao Y,Zhao L,Wang Y,Wu T,Wei L,Chen Y
Sat Jul 01 00:00:00 UTC 2017
TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration.
Oncogenesis
Gao Y,Yang Y,Yuan F,Huang J,Xu W,Mao B,Yuan Z,Bi W
Mon Sep 25 00:00:00 UTC 2017
Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments.
mAbs
Egan TJ,Diem D,Weldon R,Neumann T,Meyer S,Urech DM
300-01A was used in Affinity electrophoresis to investigate therapeutic treatments with antibodies.
Sun Jan 01 00:00:00 UTC 2017
Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro.
Journal of immunology (Baltimore, Md. : 1950)
Schaefer A,van Duijn TJ,Majolee J,Burridge K,Hordijk PL
Thu Jun 15 00:00:00 UTC 2017
Crucial Role for Immune Complexes but Not FcRn in Immunization against Anti-TNF-α Antibodies after a Single Injection in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Arnoult C,Brachet G,Cadena Castaneda D,Azzopardi N,Passot C,Desvignes C,Paintaud G,Heuzé-Vourc'h N,Watier H,Gouilleux-Gruart V
Sat Jul 15 00:00:00 UTC 2017
The Role of Shed PrPc in the Neuropathogenesis of HIV Infection.
Journal of immunology (Baltimore, Md. : 1950)
Megra BW,Eugenin EA,Berman JW
Sat Jul 01 00:00:00 UTC 2017
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Gibson A,Faulkner L,Lichtenfels M,Ogese M,Al-Attar Z,Alfirevic A,Esser PR,Martin SF,Pirmohamed M,Park BK,Naisbitt DJ
Tue Aug 15 00:00:00 UTC 2017
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
Journal of immunology (Baltimore, Md. : 1950)
Resheq YJ,Menzner AK,Bosch J,Tickle J,Li KK,Wilhelm A,Hepburn E,Murihead G,Ward ST,Curbishley SM,Zimmermann HW,Bruns T,Gilbert DF,Tripal P,Mackensen A,Adams DH,Weston CJ
Fri Sep 01 00:00:00 UTC 2017
Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis.
Journal of cellular and molecular medicine
Peng KY,Liu YH,Li YW,Yen BL,Yen ML
Tue Aug 01 00:00:00 UTC 2017
Effect of heme oxygenase-1 transduced bone marrow mesenchymal stem cells on damaged intestinal epithelial cells in vitro.
Cell biology international
Cao Y,Wu BJ,Zheng WP,Yin ML,Liu T,Song HL
Sat Jul 01 00:00:00 UTC 2017
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.
Bioscience reports
Kehlen A,Haegele M,Böhme L,Cynis H,Hoffmann T,Demuth HU
300-01A was used in In vitro experiments to suggest that QC-catalysed N-terminal pGlu formation of CX3CL1 is important for the stability or the interaction with its receptor and opens new insights into the function of QC in inflammation.
Thu Aug 31 00:00:00 UTC 2017
Three-Dimensional Coculture Model to Analyze the Cross Talk Between Endothelial and Smooth Muscle Cells.
Tissue engineering. Part C, Methods
Ganesan MK,Finsterwalder R,Leb H,Resch U,Neumüller K,de Martin R,Petzelbauer P
300-01A was used in Cell Culture to develop and validate a modified 3-dimensional sandwich coculture (3D SW-CC) of endothelial cell (EC) and smooth muscle cell (SMC) using open µ-Slides with a thin glass bottom allowing direct imaging.
Sun Jan 01 00:00:00 UTC 2017
Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness.
The Journal of biological chemistry
Bugge M,Bergstrom B,Eide OK,Solli H,Kjønstad IF,Stenvik J,Espevik T,Nilsen NJ
Fri Sep 15 00:00:00 UTC 2017
Advanced glycation endproducts link inflammatory cues to upregulation of galectin-1 in diabetic retinopathy.
Scientific reports
Kanda A,Dong Y,Noda K,Saito W,Ishida S
Thu Nov 23 00:00:00 UTC 2017
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis.
Scientific reports
Lee CH,Bae SJ,Kim M
Tue Sep 19 00:00:00 UTC 2017
The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.
Nature communications
Fusella F,Seclì L,Busso E,Krepelova A,Moiso E,Rocca S,Conti L,Annaratone L,Rubinetto C,Mello-Grand M,Singh V,Chiorino G,Silengo L,Altruda F,Turco E,Morotti A,Oliviero S,Castellano I,Cavallo F,Provero P,Tarone G,Brancaccio M
Tue Nov 21 00:00:00 UTC 2017
Expression and regulation of long noncoding RNAs during the osteogenic differentiation of periodontal ligament stem cells in the inflammatory microenvironment.
Scientific reports
Zhang Q,Chen L,Cui S,Li Y,Zhao Q,Cao W,Lai S,Yin S,Zuo Z,Ren J
Wed Oct 25 00:00:00 UTC 2017
MicroRNA-105 is involved in TNF-α-related tumor microenvironment enhanced colorectal cancer progression.
Cell death & disease
Shen Z,Zhou R,Liu C,Wang Y,Zhan W,Shao Z,Liu J,Zhang F,Xu L,Zhou X,Qi L,Bo F,Ding Y,Zhao L
Wed Dec 13 00:00:00 UTC 2017
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.
Scientific reports
Patten DA,Kamarajah SK,Rose JM,Tickle J,Shepherd EL,Adams DH,Weston CJ,Shetty S
Thu Dec 14 00:00:00 UTC 2017
Microfluidics with fluid walls.
Nature communications
Walsh EJ,Feuerborn A,Wheeler JHR,Tan AN,Durham WM,Foster KR,Cook PR
Tue Oct 10 00:00:00 UTC 2017
Systematic Identification of Mycobacterium tuberculosis Effectors Reveals that BfrB Suppresses Innate Immunity.
Molecular & cellular proteomics : MCP
He X,Jiang HW,Chen H,Zhang HN,Liu Y,Xu ZW,Wu FL,Guo SJ,Hou JL,Yang MK,Yan W,Deng JY,Bi LJ,Zhang XE,Tao SC
Fri Dec 01 00:00:00 UTC 2017
Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells.
Scientific reports
Fong LE,Sulistijo ES,Miller-Jensen K
Thu Nov 23 00:00:00 UTC 2017
Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells.
Scientific reports
Fong LE,Sulistijo ES,Miller-Jensen K
Thu Nov 23 00:00:00 UTC 2017
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Scientific reports
Liaskou E,Jeffery L,Chanouzas D,Soskic B,Seldin MF,Harper L,Sansom D,Hirschfield GM
Wed Aug 09 00:00:00 UTC 2017
STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1.
Cell death and differentiation
Jiang Y,Yu M,Hu X,Han L,Yang K,Ba H,Zhang Z,Yin B,Yang XP,Li Z,Wang J
300-01A was used in In vitro experiments to reveal an unappreciated molecular mechanism of tmTNF-α-induced apoptosis and may provide a new clue for cancer therapy.
Sat Apr 01 00:00:00 UTC 2017
STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1.
Cell death and differentiation
Jiang Y,Yu M,Hu X,Han L,Yang K,Ba H,Zhang Z,Yin B,Yang XP,Li Z,Wang J
300-01A was used in In vitro experiments to reveal an unappreciated molecular mechanism of tmTNF-α-induced apoptosis and may provide a new clue for cancer therapy.
Sat Apr 01 00:00:00 UTC 2017
STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1.
Cell death and differentiation
Jiang Y,Yu M,Hu X,Han L,Yang K,Ba H,Zhang Z,Yin B,Yang XP,Li Z,Wang J
300-01A was used in In vitro experiments to reveal an unappreciated molecular mechanism of tmTNF-α-induced apoptosis and may provide a new clue for cancer therapy.
Sat Apr 01 00:00:00 UTC 2017
LRRC25 Functions as an Inhibitor of NF-κB Signaling Pathway by Promoting p65/RelA for Autophagic Degradation.
Scientific reports
Feng Y,Duan T,Du Y,Jin S,Wang M,Cui J,Wang RF
Wed Oct 18 00:00:00 UTC 2017
Acinar injury and early cytokine response in human acute biliary pancreatitis.
Scientific reports
Jakkampudi A,Jangala R,Reddy R,Mitnala S,Rao GV,Pradeep R,Reddy DN,Talukdar R
Fri Nov 10 00:00:00 UTC 2017
N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm.
Scientific reports
Hou J,Jiang S,Zhao J,Zhu D,Zhao X,Cai JC,Zhang SQ
Mon Nov 06 00:00:00 UTC 2017
Increased tumor-infiltrating CD45RA-CCR7- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Cell death & disease
Mao FY,Kong H,Zhao YL,Peng LS,Chen W,Zhang JY,Cheng P,Wang TT,Lv YP,Teng YS,Fu XL,Liu YG,Wu XL,Hao CJ,You N,Luo P,Yu PW,Zou QM,Guo G,Zhuang Y
Thu Aug 17 00:00:00 UTC 2017
Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium.
Scientific reports
Terenzi R,Manetti M,Rosa I,Romano E,Galluccio F,Guiducci S,Ibba-Manneschi L,Matucci-Cerinic M
Mon Oct 16 00:00:00 UTC 2017
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
The Journal of biological chemistry
Majkowska I,Shitomi Y,Ito N,Gray NS,Itoh Y
Fri Apr 21 00:00:00 UTC 2017
Increased expression of Siglec-9 in chronic obstructive pulmonary disease.
Scientific reports
Zeng Z,Li M,Wang M,Wu X,Li Q,Ning Q,Zhao J,Xu Y,Xie J
Thu Aug 31 00:00:00 UTC 2017
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence.
Nature communications
Xu J,Sun Y,Li Y,Ruthel G,Weiss SR,Raj A,Beiting D,López CB
Fri Oct 06 00:00:00 UTC 2017
Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines.
Bio-protocol
Boehm D,Ott M
300-01A was used in Sample Preparation (FC/FACS) to describe a flow cytometry-based method to determine the amount of transcriptional activation of the HIV-1 LTR upon shRNA knockdown.
Mon Jun 05 00:00:00 UTC 2017
Inflammation-mediated SOD-2 upregulation contributes to epithelial-mesenchymal transition and migration of tumor cells in aflatoxin G1-induced lung adenocarcinoma.
Scientific reports
Yi L,Shen H,Zhao M,Shao P,Liu C,Cui J,Wang J,Wang C,Guo N,Kang L,Lv P,Xing L,Zhang X
Fri Aug 11 00:00:00 UTC 2017
MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4.
Cell death & disease
Hu G,Zhao X,Wang C,Geng Y,Zhao J,Xu J,Zuo B,Zhao C,Wang C,Zhang X
Thu Oct 26 00:00:00 UTC 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 UTC 2017
Human Monocytes Engage an Alternative Inflammasome Pathway.
Immunity
Gaidt MM,Ebert TS,Chauhan D,Schmidt T,Schmid-Burgk JL,Rapino F,Robertson AA,Cooper MA,Graf T,Hornung V
Tue Apr 19 00:00:00 UTC 2016
GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.
Blood
Artz A,Butz S,Vestweber D
Thu Jul 28 00:00:00 UTC 2016
Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome.
Blood
Hyvärinen S,Meri S,Jokiranta TS
Thu Jun 02 00:00:00 UTC 2016
GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease.
The Journal of experimental medicine
Stock AT,Hansen JA,Sleeman MA,McKenzie BS,Wicks IP
Mon Sep 19 00:00:00 UTC 2016
GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease.
The Journal of experimental medicine
Stock AT,Hansen JA,Sleeman MA,McKenzie BS,Wicks IP
Mon Sep 19 00:00:00 UTC 2016
EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation.
Proceedings of the National Academy of Sciences of the United States of America
Jia H,Ma X,Tong W,Doyran B,Sun Z,Wang L,Zhang X,Zhou Y,Badar F,Chandra A,Lu XL,Xia Y,Han L,Enomoto-Iwamoto M,Qin L
Tue Dec 13 00:00:00 UTC 2016
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.
Proceedings of the National Academy of Sciences of the United States of America
Zhou Q,Yu X,Demirkaya E,Deuitch N,Stone D,Tsai WL,Kuehn HS,Wang H,Yang D,Park YH,Ombrello AK,Blake M,Romeo T,Remmers EF,Chae JJ,Mullikin JC,Güzel F,Milner JD,Boehm M,Rosenzweig SD,Gadina M,Welch SB,Özen S,Topaloglu R,Abinun M,Kastner DL,Aksentijevich I
Tue Sep 06 00:00:00 UTC 2016
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.
Proceedings of the National Academy of Sciences of the United States of America
Gross CC,Schulte-Mecklenbeck A,Rünzi A,Kuhlmann T,Posevitz-Fejfár A,Schwab N,Schneider-Hohendorf T,Herich S,Held K,Konjević M,Hartwig M,Dornmair K,Hohlfeld R,Ziemssen T,Klotz L,Meuth SG,Wiendl H
Tue May 24 00:00:00 UTC 2016
Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.
Experimental & molecular medicine
Hong CY,Lee HJ,Choi NR,Jung SH,Vo MC,Hoang MD,Kim HJ,Lee JJ
Fri Aug 19 00:00:00 UTC 2016
Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.
Cell death and differentiation
Preyat N,Rossi M,Kers J,Chen L,Bertin J,Gough PJ,Le Moine A,Rongvaux A,Van Gool F,Leo O
300-01A was used in Sample Preparation (Western Blotting) to show that intracellular NAD(+) does not represent a universal pro-survival factor, but rather acts as a key metabolite regulating the choice of cell demise in response to both intrinsic and extrinsic factors.
Fri Jan 01 00:00:00 UTC 2016
miR-146a-5p inhibits TNF-α-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes.
Journal of lipid research
Wu D,Xi QY,Cheng X,Dong T,Zhu XT,Shu G,Wang LN,Jiang QY,Zhang YL
Mon Aug 01 00:00:00 UTC 2016
Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity.
Journal of lipid research
Lee MJ,Yang RZ,Karastergiou K,Smith SR,Chang JR,Gong DW,Fried SK
Fri Jul 01 00:00:00 UTC 2016
Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth.
Oncogenesis
Gari HH,DeGala GD,Lucia MS,Lambert JR
Mon Aug 15 00:00:00 UTC 2016
Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.
Cancer science
Wang J,Song X,Guo C,Wang Y,Yin Y
Thu Dec 01 00:00:00 UTC 2016
Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation.
American journal of physiology. Lung cellular and molecular physiology
Ehrhardt H,Pritzke T,Oak P,Kossert M,Biebach L,Förster K,Koschlig M,Alvira CM,Hilgendorff A
300-01A was used in In vivo experiments to suggest a critical balance between TNF-α and TGF-β signaling in the developing lung, and underscore the critical importance of these key pathways in the pathogenesis of BPD. Future treatment strategies need to weigh the potential benefits of inhibiting pathologic cytokine expression against the potential of altering key developmental pathways.
Sun May 15 00:00:00 UTC 2016
Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.
Journal of immunology (Baltimore, Md. : 1950)
Meng J,Jiang JJ,Atsumi T,Bando H,Okuyama Y,Sabharwal L,Nakagawa I,Higuchi H,Ota M,Okawara M,Ishitani R,Nureki O,Higo D,Arima Y,Ogura H,Kamimura D,Murakami M
Sat Oct 15 00:00:00 UTC 2016
RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Miller CH,Smith SM,Elguindy M,Zhang T,Xiang JZ,Hu X,Ivashkiv LB,Zhao B
Wed Jun 15 00:00:00 UTC 2016
Characterization and Application of a Unique Panel of Monoclonal Antibodies Generated against Etanercept.
Journal of immunology (Baltimore, Md. : 1950)
Detrez I,Brouwers E,Peeters M,Geukens N,de Vlam K,Gils A
Tue Mar 15 00:00:00 UTC 2016
CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata.
Journal of immunology (Baltimore, Md. : 1950)
Dai Z,Xing L,Cerise J,Wang EH,Jabbari A,de Jong A,Petukhova L,Christiano AM,Clynes R
Mon Aug 15 00:00:00 UTC 2016
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A
Tue Nov 15 00:00:00 UTC 2016
Annexin A2 Limits Neutrophil Transendothelial Migration by Organizing the Spatial Distribution of ICAM-1.
Journal of immunology (Baltimore, Md. : 1950)
Heemskerk N,Asimuddin M,Oort C,van Rijssel J,van Buul JD
Tue Mar 15 00:00:00 UTC 2016
Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis.
Journal of immunology (Baltimore, Md. : 1950)
Kanzaki H,Makihira S,Suzuki M,Ishii T,Movila A,Hirschfeld J,Mawardi H,Lin X,Han X,Taubman MA,Kawai T
Tue Nov 15 00:00:00 UTC 2016
Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells.
Journal of immunology (Baltimore, Md. : 1950)
Lopes Pinheiro MA,Kroon J,Hoogenboezem M,Geerts D,van Het Hof B,van der Pol SM,van Buul JD,de Vries HE
Fri Jan 01 00:00:00 UTC 2016
PAX5 interacts with RIP2 to promote NF-κB activation and drug-resistance in B-lymphoproliferative disorders.
Journal of cell science
Wang D,Chen J,Li R,Wu G,Sun Z,Wang Z,Zhai Z,Fang F,Guo Y,Zhong Y,Jiang M,Xu H,Chen M,Shen G,Sun J,Yan B,Yu C,Tian Z,Xiao W
300-01A was used in In vitro experiments to reveal that hyperphosphorylation of RIP2 by PAX5 intensifies NF-κB activity, presenting resistance to chemotherapeutic drugs, especially for B-lymphoproliferative disorders (B-LPDs).
Wed Jun 01 00:00:00 UTC 2016
Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway.
Molecular and cellular biology
Saito S,Cigdem S,Okuwaki M,Nagata K
300-01A was used in Cell Culture to investigate nuclear transport proteins in diseases.
Fri Jul 01 00:00:00 UTC 2016
Follistatin-like protein 1 contributes to dendritic cell and T-lymphocyte activation in nasopharyngeal carcinoma patients by altering nuclear factor κb and Jun N-terminal kinase expression.
Cell biochemistry and function
Wang H,Wu S,Huang S,Yin S,Zou G,Huang K,Zhang Z,Tang A,Wen W
Thu Dec 01 00:00:00 UTC 2016
Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
The Journal of biological chemistry
Wakita M,Edamatsu H,Li M,Emi A,Kitazawa S,Kataoka T
Fri Jun 10 00:00:00 UTC 2016
Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.
Scientific reports
Liu Q,Zhang X,Hu X,Dai L,Fu X,Zhang J,Ao Y
Wed Mar 02 00:00:00 UTC 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 UTC 2016
F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.
Nature communications
Heemskerk N,Schimmel L,Oort C,van Rijssel J,Yin T,Ma B,van Unen J,Pitter B,Huveneers S,Goedhart J,Wu Y,Montanez E,Woodfin A,van Buul JD
Wed Jan 27 00:00:00 UTC 2016
IFNα enhances the production of IL-6 by human neutrophils activated via TLR8.
Scientific reports
Zimmermann M,Arruda-Silva F,Bianchetto-Aguilera F,Finotti G,Calzetti F,Scapini P,Lunardi C,Cassatella MA,Tamassia N
Thu Jan 21 00:00:00 UTC 2016
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.
Scientific reports
Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M
Wed Nov 09 00:00:00 UTC 2016
Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure.
Cell death & disease
Komarov AP,Komarova EA,Green K,Novototskaya LR,Baker PS,Eroshkin A,Osterman AL,Chenchick AA,Frangou C,Gudkov AV
Thu Mar 17 00:00:00 UTC 2016
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.
Scientific reports
Lombardo G,Dentelli P,Togliatto G,Rosso A,Gili M,Gallo S,Deregibus MC,Camussi G,Brizzi MF
Mon May 09 00:00:00 UTC 2016
Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP).
The Journal of biological chemistry
Baratchian M,Davis CA,Shimizu A,Escors D,Bagnéris C,Barrett T,Collins MK
Fri Apr 01 00:00:00 UTC 2016
Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells.
Scientific reports
Fazio C,Piazzi G,Vitaglione P,Fogliano V,Munarini A,Prossomariti A,Milazzo M,D'Angelo L,Napolitano M,Chieco P,Belluzzi A,Bazzoli F,Ricciardiello L
Thu Feb 11 00:00:00 UTC 2016
CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.
Scientific reports
Su S,Hu B,Shao J,Shen B,Du J,Du Y,Zhou J,Yu L,Zhang L,Chen F,Sha H,Cheng L,Meng F,Zou Z,Huang X,Liu B
Thu Jan 28 00:00:00 UTC 2016
Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1.
Scientific reports
Wang C,Huo X,Wang L,Meng Q,Liu Z,Liu Q,Sun H,Sun P,Peng J,Liu K
Wed Jun 22 00:00:00 UTC 2016
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Cell death & disease
Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G
Thu Sep 08 00:00:00 UTC 2016
Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling.
Scientific reports
Chandrika G,Natesh K,Ranade D,Chugh A,Shastry P
Fri Mar 04 00:00:00 UTC 2016
The MK2/HuR signaling pathway regulates TNF-α-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNA.
BMC pulmonary medicine
Wu T,Shi JX,Geng S,Zhou W,Shi Y,Su X
300-01A was used in In vitro experiments to indicate that p38/activated protein kinase 2 post-transcriptionally regulates TNF-α-induced ICAM-1 expression by altering the cytoplasmic localization of human antigen R in human lung microvascular endothelial cells.
Mon May 23 00:00:00 UTC 2016
Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION.
The Journal of biological chemistry
Dougherty EJ,Elinoff JM,Ferreyra GA,Hou A,Cai R,Sun J,Blaine KP,Wang S,Danner RL
Fri Nov 04 00:00:00 UTC 2016
Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection.
Oncotarget
Danziger O,Shai B,Sabo Y,Bacharach E,Ehrlich M
300-01A was used in Cell Culture to propose that epigenetic modifiers and virotherapy are compatible in treatment of prostate tumors defective in JAK1 expression and IFN signaling.
Tue Aug 09 00:00:00 UTC 2016
Rapid and label-free microfluidic neutrophil purification and phenotyping in diabetes mellitus.
Scientific reports
Hou HW,Petchakup C,Tay HM,Tam ZY,Dalan R,Chew DE,Li KH,Boehm BO
Wed Jul 06 00:00:00 UTC 2016
Rapid and label-free microfluidic neutrophil purification and phenotyping in diabetes mellitus.
Scientific reports
Hou HW,Petchakup C,Tay HM,Tam ZY,Dalan R,Chew DE,Li KH,Boehm BO
Wed Jul 06 00:00:00 UTC 2016
NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector.
Scientific reports
Machitani M,Sakurai F,Wakabayashi K,Nakatani K,Shimizu K,Tachibana M,Mizuguchi H
Wed Jan 27 00:00:00 UTC 2016
Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells.
The Journal of biological chemistry
Suzuki S,Ogawa M,Ohta S,Nunomura S,Nanri Y,Shiraishi H,Mitamura Y,Yoshihara T,Lee JJ,Izuhara K
Fri Dec 30 00:00:00 UTC 2016
TNF-α increases the expression and activity of vitamin D receptor in keratinocytes: role of c-Jun N-terminal kinase.
Dermato-endocrinology
Ziv E,Koren R,Zahalka MA,Ravid A
300-01A was used in In vitro experiments to surmise that the increased generation and sensitivity to calcitriol in keratinocytes play a role in the resolution of epidermal inflammation.
Thu May 19 00:00:00 UTC 2016
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
The Journal of biological chemistry
Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y
Fri Aug 26 00:00:00 UTC 2016
Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.
Scientific reports
Miquel S,Martín R,Lashermes A,Gillet M,Meleine M,Gelot A,Eschalier A,Ardid D,Bermúdez-Humarán LG,Sokol H,Thomas M,Theodorou V,Langella P,Carvalho FA
Mon Jan 18 00:00:00 UTC 2016
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.
Scientific reports
Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB
Thu Aug 25 00:00:00 UTC 2016
Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop.
Scientific reports
Kechagia JZ,Ezra DG,Burton MJ,Bailly M
Mon Jun 20 00:00:00 UTC 2016
CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.
Scientific reports
Yeap WH,Wong KL,Shimasaki N,Teo EC,Quek JK,Yong HX,Diong CP,Bertoletti A,Linn YC,Wong SC
Tue Sep 27 00:00:00 UTC 2016
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.
Cell death & disease
de Mingo Á,de Gregorio E,Moles A,Tarrats N,Tutusaus A,Colell A,Fernandez-Checa JC,Morales A,Marí M
Thu Nov 10 00:00:00 UTC 2016
Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity.
mAbs
Karle A,Spindeldreher S,Kolbinger F
300-01A was used in Cell Culture to evaluate its immunogenicity potential by applying 2 different in vitro assays: T-cell activation and major histocompatibility complex-associated peptide proteomics (MAPPs).
Tue Dec 13 00:00:00 UTC 2016
γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.
The Journal of biological chemistry
Chhibber-Goel J,Coleman-Vaughan C,Agrawal V,Sawhney N,Hickey E,Powell JC,McCarthy JV
Fri Mar 11 00:00:00 UTC 2016
Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis.
Scientific reports
Zheng Z,Jiang H,Huang Y,Wang J,Qiu L,Hu Z,Ma X,Lu Y
Mon May 09 00:00:00 UTC 2016
Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs.
The Journal of biological chemistry
Krock E,Currie JB,Weber MH,Ouellet JA,Stone LS,Rosenzweig DH,Haglund L
Fri Feb 12 00:00:00 UTC 2016
TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling.
Scientific reports
Liu L,Song H,Duan H,Chai J,Yang J,Li X,Yu Y,Zhang X,Hu X,Xiao M,Feng R,Yin H,Hu Q,Yang L,Du J,Li T
Fri Jul 22 00:00:00 UTC 2016
Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease.
Scientific reports
Schamberger AC,Schiller HB,Fernandez IE,Sterclova M,Heinzelmann K,Hennen E,Hatz R,Behr J,Vašáková M,Mann M,Eickelberg O,Staab-Weijnitz CA
Wed Jul 20 00:00:00 UTC 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
Mon Nov 28 00:00:00 UTC 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
Mon Nov 28 00:00:00 UTC 2016
Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application.
Scientific reports
Mohamed H,Chernajovsky Y,Gould D
Fri Jul 08 00:00:00 UTC 2016
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Nature
Carmi Y,Spitzer MH,Linde IL,Burt BM,Prestwood TR,Perlman N,Davidson MG,Kenkel JA,Segal E,Pusapati GV,Bhattacharya N,Engleman EG
Thu May 07 00:00:00 UTC 2015
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
The Journal of clinical investigation
Chen PY,Qin L,Baeyens N,Li G,Afolabi T,Budatha M,Tellides G,Schwartz MA,Simons M
Mon Oct 26 00:00:00 UTC 2015
Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.
The Journal of experimental medicine
Frye M,Dierkes M,Küppers V,Vockel M,Tomm J,Zeuschner D,Rossaint J,Zarbock A,Koh GY,Peters K,Nottebaum AF,Vestweber D
Mon Dec 14 00:00:00 UTC 2015
Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin.
Cancer research
Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P
300-01A was used in Cell Culture to illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators.
Wed Apr 15 00:00:00 UTC 2015
TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Pilling D,Vakil V,Cox N,Gomer RH
Tue Sep 22 00:00:00 UTC 2015
C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Muthana M,Hawtree S,Wilshaw A,Linehan E,Roberts H,Khetan S,Adeleke G,Wright F,Akil M,Fearon U,Veale D,Ciani B,Wilson AG
Tue Sep 15 00:00:00 UTC 2015
Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.
Acta physiologica (Oxford, England)
Jean-Gilles L,Braitch M,Latif ML,Aram J,Fahey AJ,Edwards LJ,Robins RA,Tanasescu R,Tighe PJ,Gran B,Showe LC,Alexander SP,Chapman V,Kendall DA,Constantinescu CS
Fri May 01 00:00:00 UTC 2015
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
Journal of lipid research
Benesch MG,Zhao YY,Curtis JM,McMullen TP,Brindley DN
Mon Jun 01 00:00:00 UTC 2015
Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
Cancer science
Fukushima K,Tsuchiya K,Kano Y,Horita N,Hibiya S,Hayashi R,Kitagaki K,Negi M,Itoh E,Akashi T,Eishi Y,Oshima S,Nagaishi T,Okamoto R,Nakamura T,Watanabe M
Sat Aug 01 00:00:00 UTC 2015
Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells.
Stem cells (Dayton, Ohio)
Estève D,Boulet N,Volat F,Zakaroff-Girard A,Ledoux S,Coupaye M,Decaunes P,Belles C,Gaits-Iacovoni F,Iacovoni JS,Rémaury A,Castel B,Ferrara P,Heymes C,Lafontan M,Bouloumié A,Galitzky J
Wed Apr 01 00:00:00 UTC 2015
CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio)
Yang Z,Dong P,Fu X,Li Q,Ma S,Wu D,Kang N,Liu X,Yan L,Xiao R
Tue Sep 01 00:00:00 UTC 2015
Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chadet S,Ivanes F,Benoist L,Salmon-Gandonnière C,Guibon R,Velge-Roussel F,Babuty D,Baron C,Roger S,Angoulvant D
Wed Jul 15 00:00:00 UTC 2015
Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.
Journal of immunology (Baltimore, Md. : 1950)
Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH
Thu Oct 15 00:00:00 UTC 2015
IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Broux B,Mizee MR,Vanheusden M,van der Pol S,van Horssen J,Van Wijmeersch B,Somers V,de Vries HE,Stinissen P,Hellings N
Sun Mar 01 00:00:00 UTC 2015
Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo.
Journal of cellular and molecular medicine
Fuchs S,Hsieh LT,Saarberg W,Erdelmeier CA,Wichelhaus TA,Schaefer L,Koch E,Fürst R
Fri May 01 00:00:00 UTC 2015
Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.
Endocrinology
Matsuda K,Fujishima Y,Maeda N,Mori T,Hirata A,Sekimoto R,Tsushima Y,Masuda S,Yamaoka M,Inoue K,Nishizawa H,Kita S,Ranscht B,Funahashi T,Shimomura I
300-01A was used in Sample Preparation to investigate adiponectin interaction with ECM.
Sun Mar 01 00:00:00 UTC 2015
Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action.
CPT: pharmacometrics & systems pharmacology
Michailidou M,Melas IN,Messinis DE,Klamt S,Alexopoulos LG,Kolisis FN,Loutrari H
Mon Jun 01 00:00:00 UTC 2015
Immuno-analysis of microparticles: probing at the limits of detection.
Scientific reports
Latham SL,Tiberti N,Gokoolparsadh N,Holdaway K,Couraud PO,Grau GE,Combes V
Tue Nov 10 00:00:00 UTC 2015
USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.
Scientific reports
Yang Z,Xian H,Hu J,Tian S,Qin Y,Wang RF,Cui J
Tue Aug 04 00:00:00 UTC 2015
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
The Journal of biological chemistry
Hernández-Corbacho MJ,Canals D,Adada MM,Liu M,Senkal CE,Yi JK,Mao C,Luberto C,Hannun YA,Obeid LM
Fri Oct 16 00:00:00 UTC 2015
A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival.
Cell death discovery
Hernandez L,Kim MK,Noonan AM,Sagher E,Kohlhammer H,Wright G,Lyle LT,Steeg PS,Anver M,Bowtell DD,Annunziata CM
300-01A was used in Sample Preparation to investigate the effects of Caspase8 depletion on apoptosis and necroptosis of TNFα-stimulated ovarian cancer cell lines.
Sat Jun 15 00:00:00 UTC 2024
The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation.
The Journal of biological chemistry
Silva JP,Vetterlein O,Jose J,Peters S,Kirby H
Fri Feb 27 00:00:00 UTC 2015
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell death & disease
Ottina E,Sochalska M,Sgonc R,Villunger A
Thu Jan 22 00:00:00 UTC 2015
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell death & disease
Ottina E,Sochalska M,Sgonc R,Villunger A
Thu Jan 22 00:00:00 UTC 2015
Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.
Scientific reports
Yang P,Zhao Y,Zhao L,Yuan J,Chen Y,Varghese Z,Moorhead JF,Chen Y,Ruan XZ
Fri Oct 09 00:00:00 UTC 2015
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.
The Journal of biological chemistry
Park ES,Choi S,Shin B,Yu J,Yu J,Hwang JM,Yun H,Chung YH,Choi JS,Choi Y,Rho J
Fri Apr 10 00:00:00 UTC 2015
Hsa-miR-19a is associated with lymph metastasis and mediates the TNF-α induced epithelial-to-mesenchymal transition in colorectal cancer.
Scientific reports
Huang L,Wang X,Wen C,Yang X,Song M,Chen J,Wang C,Zhang B,Wang L,Iwamoto A,Wang J,Liu H
Tue Aug 25 00:00:00 UTC 2015
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.
Scientific reports
Lu J,Zeng H,Liang Z,Chen L,Zhang L,Zhang H,Liu H,Jiang H,Shen B,Huang M,Geng M,Spiegel S,Luo C
Thu Oct 08 00:00:00 UTC 2015
CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment.
Scientific reports
Zhang QQ,Hu XW,Liu YL,Ye ZJ,Gui YH,Zhou DL,Qi CL,He XD,Wang H,Wang LJ
Tue Nov 03 00:00:00 UTC 2015
CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment.
Scientific reports
Zhang QQ,Hu XW,Liu YL,Ye ZJ,Gui YH,Zhou DL,Qi CL,He XD,Wang H,Wang LJ
Tue Nov 03 00:00:00 UTC 2015
Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.
Scientific reports
Liu J,Zhou F,Chen Q,Kang A,Lu M,Liu W,Zang X,Wang G,Zhang J
Tue Sep 01 00:00:00 UTC 2015
Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.
The Journal of biological chemistry
Burzynski LC,Humphry M,Bennett MR,Clarke MC
Fri Oct 09 00:00:00 UTC 2015
Investigation of Tumor Cell Behaviors on a Vascular Microenvironment-Mimicking Microfluidic Chip.
Scientific reports
Huang R,Zheng W,Liu W,Zhang W,Long Y,Jiang X
Thu Dec 03 00:00:00 UTC 2015
MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.
The Journal of biological chemistry
Park H,Huang X,Lu C,Cairo MS,Zhou X
Fri Jan 30 00:00:00 UTC 2015
Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6.
The Journal of biological chemistry
Cao G,Wang J,Zheng X,Wei H,Tian Z,Sun R
Fri Dec 11 00:00:00 UTC 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 UTC 2015
Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.
Cell death & disease
Brown MF,Leibowitz BJ,Chen D,He K,Zou F,Sobol RW,Beer-Stolz D,Zhang L,Yu J
Thu Apr 23 00:00:00 UTC 2015
Distinct promoter activation mechanisms modulate noise-driven HIV gene expression.
Scientific reports
Chavali AK,Wong VC,Miller-Jensen K
Tue Dec 15 00:00:00 UTC 2015
A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
The Journal of biological chemistry
López-Cotarelo P,Escribano-Díaz C,González-Bethencourt IL,Gómez-Moreira C,Deguiz ML,Torres-Bacete J,Gómez-Cabañas L,Fernández-Barrera J,Delgado-Martín C,Mellado M,Regueiro JR,Miranda-Carús ME,Rodríguez-Fernández JL
Fri Jan 09 00:00:00 UTC 2015
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.
Cell death & disease
Fauster A,Rebsamen M,Huber KV,Bigenzahn JW,Stukalov A,Lardeau CH,Scorzoni S,Bruckner M,Gridling M,Parapatics K,Colinge J,Bennett KL,Kubicek S,Krautwald S,Linkermann A,Superti-Furga G
Thu May 21 00:00:00 UTC 2015
Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.
Scientific reports
Zhu H,Wan X,Li J,Han L,Bo X,Chen W,Lu C,Shen Z,Xu C,Chen L,Yu C,Xu G
Fri Jul 17 00:00:00 UTC 2015
Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.
The Journal of biological chemistry
Pontejo SM,Alejo A,Alcami A
Fri Jun 26 00:00:00 UTC 2015
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Nature communications
Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M
Wed Nov 04 00:00:00 UTC 2015
Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate.
Nature communications
Krishnan RK,Nolte H,Sun T,Kaur H,Sreenivasan K,Looso M,Offermanns S,Krüger M,Swiercz JM
Tue Apr 07 00:00:00 UTC 2015
Galectin-1 regulates tissue exit of specific dendritic cell populations.
The Journal of biological chemistry
Thiemann S,Man JH,Chang MH,Lee B,Baum LG
Fri Sep 11 00:00:00 UTC 2015
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.
Nature
Bald T,Quast T,Landsberg J,Rogava M,Glodde N,Lopez-Ramos D,Kohlmeyer J,Riesenberg S,van den Boorn-Konijnenberg D,Hömig-Hölzel C,Reuten R,Schadow B,Weighardt H,Wenzel D,Helfrich I,Schadendorf D,Bloch W,Bianchi ME,Lugassy C,Barnhill RL,Koch M,Fleischmann BK,Förster I,Kastenmüller W,Kolanus W,Hölzel M,Gaffal E,Tüting T
Thu Mar 06 00:00:00 UTC 2014
Sensitizing protective tumor microenvironments to antibody-mediated therapy.
Cell
Pallasch CP,Leskov I,Braun CJ,Vorholt D,Drake A,Soto-Feliciano YM,Bent EH,Schwamb J,Iliopoulou B,Kutsch N,van Rooijen N,Frenzel LP,Wendtner CM,Heukamp L,Kreuzer KA,Hallek M,Chen J,Hemann MT
Thu Jan 30 00:00:00 UTC 2014
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Cancer cell
Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E
Mon May 12 00:00:00 UTC 2014
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
The Journal of experimental medicine
Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T
Mon Jun 02 00:00:00 UTC 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
Fri Aug 01 00:00:00 UTC 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 UTC 2014
Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Natarajan V,Komarov AP,Ippolito T,Bonneau K,Chenchik AA,Gudkov AV
Tue Jan 28 00:00:00 UTC 2014
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
Proceedings of the National Academy of Sciences of the United States of America
Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M
Tue Oct 14 00:00:00 UTC 2014
Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate.
Proceedings of the National Academy of Sciences of the United States of America
Yuan S,Dong X,Tao X,Xu L,Ruan J,Peng J,Xu A
Tue May 06 00:00:00 UTC 2014
Endothelial microparticles interact with and support the proliferation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wheway J,Latham SL,Combes V,Grau GE
Wed Oct 01 00:00:00 UTC 2014
Endothelial microparticles interact with and support the proliferation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wheway J,Latham SL,Combes V,Grau GE
Wed Oct 01 00:00:00 UTC 2014
Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Joedicke JJ,Myers L,Carmody AB,Messer RJ,Wajant H,Lang KS,Lang PA,Mak TW,Hasenkrug KJ,Dittmer U
Mon Sep 15 00:00:00 UTC 2014
Lidocaine reduces neutrophil recruitment by abolishing chemokine-induced arrest and transendothelial migration in septic patients.
Journal of immunology (Baltimore, Md. : 1950)
Berger C,Rossaint J,Van Aken H,Westphal M,Hahnenkamp K,Zarbock A
Wed Jan 01 00:00:00 UTC 2014
IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Herr F,Lemoine R,Gouilleux F,Meley D,Kazma I,Heraud A,Velge-Roussel F,Baron C,Lebranchu Y
Sun Jun 15 00:00:00 UTC 2014
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.
Journal of immunology (Baltimore, Md. : 1950)
Ba X,Bacsi A,Luo J,Aguilera-Aguirre L,Zeng X,Radak Z,Brasier AR,Boldogh I
Sat Mar 01 00:00:00 UTC 2014
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.
Journal of immunology (Baltimore, Md. : 1950)
Ba X,Bacsi A,Luo J,Aguilera-Aguirre L,Zeng X,Radak Z,Brasier AR,Boldogh I
Sat Mar 01 00:00:00 UTC 2014
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.
Journal of immunology (Baltimore, Md. : 1950)
Ba X,Bacsi A,Luo J,Aguilera-Aguirre L,Zeng X,Radak Z,Brasier AR,Boldogh I
Sat Mar 01 00:00:00 UTC 2014
Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Fernandes P,O'Donnell C,Lyons C,Keane J,Regan T,O'Brien S,Fallon P,Brint E,Houston A
Mon Dec 15 00:00:00 UTC 2014
Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Epaulard O,Adam L,Poux C,Zurawski G,Salabert N,Rosenbaum P,Dereuddre-Bosquet N,Zurawski S,Flamar AL,Oh S,Romain G,Chapon C,Banchereau J,Lévy Y,Le Grand R,Martinon F
Mon Sep 01 00:00:00 UTC 2014
IL-32 promotes angiogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Nold-Petry CA,Rudloff I,Baumer Y,Ruvo M,Marasco D,Botti P,Farkas L,Cho SX,Zepp JA,Azam T,Dinkel H,Palmer BE,Boisvert WA,Cool CD,Taraseviciene-Stewart L,Heinhuis B,Joosten LA,Dinarello CA,Voelkel NF,Nold MF
Wed Jan 15 00:00:00 UTC 2014
The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
Cancer cell international
Sagher E,Hernandez L,Heywood C,Pauly GT,Young MR,Schneider J,Colburn NH,Annunziata CM
300-01A was used in Cell Culture to suggest that the small molecule NSC676914A shows promising NF-κB-independent anti-cancer activity in ovarian tumor cells.
Fri Oct 17 00:00:00 UTC 2014
The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
Cancer cell international
Sagher E,Hernandez L,Heywood C,Pauly GT,Young MR,Schneider J,Colburn NH,Annunziata CM
300-01A was used in Cell Culture to suggest that the small molecule NSC676914A shows promising NF-κB-independent anti-cancer activity in ovarian tumor cells.
Fri Oct 17 00:00:00 UTC 2014
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.
Cell death & disease
Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T
Thu May 15 00:00:00 UTC 2014
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.
Cell death & disease
Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T
Thu May 15 00:00:00 UTC 2014
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
BMC genomics
Selinger C,Tisoncik-Go J,Menachery VD,Agnihothram S,Law GL,Chang J,Kelly SM,Sova P,Baric RS,Katze MG
300-01A was used in Cell Culture to carry out comparative transcriptional analysis of human Calu-3 cell host responses to the different coronavirus in the Middle East (MERS-CoV) strains.
Mon Dec 22 00:00:00 UTC 2014
Controlling resistant bacteria with a novel class of β-lactamase inhibitor peptides: from rational design to in vivo analyses.
Scientific reports
Mandal SM,Migliolo L,Silva ON,Fensterseifer IC,Faria-Junior C,Dias SC,Basak A,Hazra TK,Franco OL
Mon Aug 11 00:00:00 UTC 2014
DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes.
The Journal of biological chemistry
Sakaguchi M,Murata H,Aoyama Y,Hibino T,Putranto EW,Ruma IM,Inoue Y,Sakaguchi Y,Yamamoto K,Kinoshita R,Futami J,Kataoka K,Iwatsuki K,Huh NH
Fri Aug 22 00:00:00 UTC 2014
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
The Journal of biological chemistry
Perry DM,Newcomb B,Adada M,Wu BX,Roddy P,Kitatani K,Siskind L,Obeid LM,Hannun YA
Fri Aug 08 00:00:00 UTC 2014
Modulation of gene expression regulated by the transcription factor NF-κB/RelA.
The Journal of biological chemistry
Li X,Zhao Y,Tian B,Jamaluddin M,Mitra A,Yang J,Rowicka M,Brasier AR,Kudlicki A
Fri Apr 25 00:00:00 UTC 2014
The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.
BMC cancer
Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A
300-01A was used in Sample Preparation (ELISA) to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.
Thu Mar 06 00:00:00 UTC 2014
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Nature communications
Henze AT,Garvalov BK,Seidel S,Cuesta AM,Ritter M,Filatova A,Foss F,Dopeso H,Essmann CL,Maxwell PH,Reifenberger G,Carmeliet P,Acker-Palmer A,Acker T
Tue Nov 25 00:00:00 UTC 2014
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).
The Journal of biological chemistry
Liu J,Han L,Li B,Yang J,Huen MS,Pan X,Tsao SW,Cheung AL
Fri Aug 01 00:00:00 UTC 2014
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
300-01A was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 UTC 2015
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
300-01A was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 UTC 2015
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 UTC 2014
Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.
Cell death & disease
Hashimoto M,Nasser H,Chihara T,Suzu S
Thu May 29 00:00:00 UTC 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 UTC 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 UTC 2014
HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.
Cell death & disease
Li T,Guan J,Li S,Zhang X,Zheng X
Thu May 15 00:00:00 UTC 2014
The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.
The Journal of biological chemistry
Wilhelmsen K,Khakpour S,Tran A,Sheehan K,Schumacher M,Xu F,Hellman J
Fri May 09 00:00:00 UTC 2014
URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.
Cell death & disease
Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY
Thu Mar 13 00:00:00 UTC 2014
Endosomal signaling by protease-activated receptors.
Methods in enzymology
Grimsey N,Lin H,Trejo J
300-01A was used in In vitro experiments to provide an overview of methods and strategies used to examine endosomal signaling by PARs.
Mon Aug 11 00:00:00 UTC 2014
Women with the Alzheimer's risk marker ApoE4 lose Aβ-specific CD4⁺ T cells 10-20 years before men.
Translational psychiatry
Begum AN,Cunha C,Sidhu H,Alkam T,Scolnick J,Rosario ER,Ethell DW
Tue Jul 29 00:00:00 UTC 2014
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Scientific reports
Chen CF,Feng X,Liao HY,Jin WJ,Zhang J,Wang Y,Gong LL,Liu JJ,Yuan XH,Zhao BB,Zhang D,Chen GF,Wan Y,Guo J,Yan HP,He YW
Mon Sep 15 00:00:00 UTC 2014
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
The Journal of biological chemistry
Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB
Fri May 02 00:00:00 UTC 2014
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
The Journal of biological chemistry
Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB
Fri May 02 00:00:00 UTC 2014
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV
Fri Mar 14 00:00:00 UTC 2014
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV
Fri Mar 14 00:00:00 UTC 2014
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.
Cell
Yan J,Xiang J,Lin Y,Ma J,Zhang J,Zhang H,Sun J,Danial NN,Liu J,Lin A
Thu Jan 17 00:00:00 UTC 2013
A reversible gene trap collection empowers haploid genetics in human cells.
Nature methods
Bürckstümmer T,Banning C,Hainzl P,Schobesberger R,Kerzendorfer C,Pauler FM,Chen D,Them N,Schischlik F,Rebsamen M,Smida M,Fece de la Cruz F,Lapao A,Liszt M,Eizinger B,Guenzl PM,Blomen VA,Konopka T,Gapp B,Parapatics K,Maier B,Stöckl J,Fischl W,Salic S,Taba Casari MR,Knapp S,Bennett KL,Bock C,Colinge J,Kralovics R,Ammerer G,Casari G,Brummelkamp TR,Superti-Furga G,Nijman SM
Tue Oct 01 00:00:00 UTC 2013
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
Immunity
Obermoser G,Presnell S,Domico K,Xu H,Wang Y,Anguiano E,Thompson-Snipes L,Ranganathan R,Zeitner B,Bjork A,Anderson D,Speake C,Ruchaud E,Skinner J,Alsina L,Sharma M,Dutartre H,Cepika A,Israelsson E,Nguyen P,Nguyen QA,Harrod AC,Zurawski SM,Pascual V,Ueno H,Nepom GT,Quinn C,Blankenship D,Palucka K,Banchereau J,Chaussabel D
Thu Apr 18 00:00:00 UTC 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 UTC 2013
Space exploration by the promoter of a long human gene during one transcription cycle.
Nucleic acids research
Larkin JD,Papantonis A,Cook PR,Marenduzzo D
Fri Feb 01 00:00:00 UTC 2013
MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
The Journal of experimental medicine
Long HM,Chagoury OL,Leese AM,Ryan GB,James E,Morton LT,Abbott RJ,Sabbah S,Kwok W,Rickinson AB
Mon May 06 00:00:00 UTC 2013
Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.
The Journal of experimental medicine
Das S,Sarrou E,Podgrabinska S,Cassella M,Mungamuri SK,Feirt N,Gordon R,Nagi CS,Wang Y,Entenberg D,Condeelis J,Skobe M
Mon Jul 29 00:00:00 UTC 2013
Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America
Verjee LS,Verhoekx JS,Chan JK,Krausgruber T,Nicolaidou V,Izadi D,Davidson D,Feldmann M,Midwood KS,Nanchahal J
Tue Mar 05 00:00:00 UTC 2013
Long noncoding RNAs regulate adipogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Sun L,Goff LA,Trapnell C,Alexander R,Lo KA,Hacisuleyman E,Sauvageau M,Tazon-Vega B,Kelley DR,Hendrickson DG,Yuan B,Kellis M,Lodish HF,Rinn JL
Tue Feb 26 00:00:00 UTC 2013
Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.
PLoS pathogens
Chen Y,Hwang SL,Chan VS,Chung NP,Wang SR,Li Z,Ma J,Lin CW,Hsieh YJ,Chang KP,Kung SS,Wu YC,Chu CW,Tai HT,Gao GF,Zheng B,Yokoyama KK,Austyn JM,Lin CL
Tue Jan 01 00:00:00 UTC 2013
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.
PLoS pathogens
Mansur DS,Maluquer de Motes C,Unterholzner L,Sumner RP,Ferguson BJ,Ren H,Strnadova P,Bowie AG,Smith GL
Fri Feb 01 00:00:00 UTC 2013
TNF-α has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8.
Stem cells (Dayton, Ohio)
Mizrahi K,Stein J,Yaniv I,Kaplan O,Askenasy N
Tue Jan 01 00:00:00 UTC 2013
Trp53 deficiency protects against acute intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Spehlmann ME,Manthey CF,Dann SM,Hanson E,Sandhu SS,Liu LY,Abdelmalak FK,Diamanti MA,Retzlaff K,Scheller J,Rose-John S,Greten FR,Wang JY,Eckmann L
Mon Jul 15 00:00:00 UTC 2013
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M
Wed May 01 00:00:00 UTC 2013
Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Hagberg N,Theorell J,Schlums H,Eloranta ML,Bryceson YT,Rönnblom L
Sun Sep 15 00:00:00 UTC 2013
Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.
Journal of immunology (Baltimore, Md. : 1950)
Datta A,Alexander R,Sulikowski MG,Nicholson AG,Maher TM,Scotton CJ,Chambers RC
Fri Nov 01 00:00:00 UTC 2013
MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B.
Journal of immunology (Baltimore, Md. : 1950)
Wang S,Zhang X,Ju Y,Zhao B,Yan X,Hu J,Shi L,Yang L,Ma Z,Chen L,Liu Y,Duan Z,Chen X,Meng S
Mon Jul 01 00:00:00 UTC 2013
Adam8 limits the development of allergic airway inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA
Sat Jun 15 00:00:00 UTC 2013
Fast dendritic cells stimulated with alternative maturation mixtures induce polyfunctional and long-lasting activation of innate and adaptive effector cells with tumor-killing capabilities.
Journal of immunology (Baltimore, Md. : 1950)
Massa C,Seliger B
Mon Apr 01 00:00:00 UTC 2013
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.
Journal of immunology (Baltimore, Md. : 1950)
Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N
Sun Sep 15 00:00:00 UTC 2013
Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.
Journal of immunology (Baltimore, Md. : 1950)
Fumagalli L,Campa CC,Germena G,Lowell CA,Hirsch E,Berton G
Mon Apr 01 00:00:00 UTC 2013
Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.
Journal of immunology (Baltimore, Md. : 1950)
Herlihy SE,Pilling D,Maharjan AS,Gomer RH
Sat Jun 15 00:00:00 UTC 2013
Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.
Mediators of inflammation
Weitzenfeld P,Meron N,Leibovich-Rivkin T,Meshel T,Ben-Baruch A
300-01A was used in In vitro experiments to indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.
Thu Jun 05 00:00:00 UTC 2014
Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer.
PloS one
Wang H,Wang HS,Zhou BH,Li CL,Zhang F,Wang XF,Zhang G,Bu XZ,Cai SH,Du J
Thu Aug 15 00:00:00 UTC 2013
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
The Journal of biological chemistry
Ferreira E,Porter RM,Wehling N,O'Sullivan RP,Liu F,Boskey A,Estok DM,Harris MB,Vrahas MS,Evans CH,Wells JW
Fri Oct 11 00:00:00 UTC 2013
Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation.
The Journal of biological chemistry
Lee M,Choy JC
Fri May 31 00:00:00 UTC 2013
Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity.
Cell death & disease
Lefebvre J,Muharram G,Leroy C,Kherrouche Z,Montagne R,Ichim G,Tauszig-Delamasure S,Chotteau-Lelievre A,Brenner C,Mehlen P,Tulasne D
Thu Oct 17 00:00:00 UTC 2013
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
The Journal of biological chemistry
Hong S,Kim HY,Kim J,Ha HT,Kim YM,Bae E,Kim TH,Lee KC,Kim SJ
Fri Feb 01 00:00:00 UTC 2013
TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier.
Journal of neuroinflammation
Stephan D,Sbai O,Wen J,Couraud PO,Putterman C,Khrestchatisky M,Desplat-Jégo S
Tue Jan 15 00:00:00 UTC 2013
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.
The Journal of biological chemistry
Wang N,Zimmerman K,Raab RW,McKown RL,Hutnik CM,Talla V,Tyler MF,Lee JK,Laurie GW
Fri Jun 21 00:00:00 UTC 2013
Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
PloS one
Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR
Tue Jul 09 00:00:00 UTC 2013
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV
Fri Jun 07 00:00:00 UTC 2013
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV
Fri Jun 07 00:00:00 UTC 2013
Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation.
The Journal of biological chemistry
Adada MM,Orr-Gandy KA,Snider AJ,Canals D,Hannun YA,Obeid LM,Clarke CJ
Fri Sep 20 00:00:00 UTC 2013
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
PloS one
McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A
Tue Aug 27 00:00:00 UTC 2013
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.
The Journal of biological chemistry
Ingvarsen S,Porse A,Erpicum C,Maertens L,Jürgensen HJ,Madsen DH,Melander MC,Gårdsvoll H,Høyer-Hansen G,Noel A,Holmbeck K,Engelholm LH,Behrendt N
Fri Apr 12 00:00:00 UTC 2013
Cross-species analysis reveals evolving and conserved features of the nuclear factor κB (NF-κB) proteins.
The Journal of biological chemistry
Ryzhakov G,Teixeira A,Saliba D,Blazek K,Muta T,Ragoussis J,Udalova IA
Fri Apr 19 00:00:00 UTC 2013
Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures.
Neoplasia (New York, N.Y.)
Leibovich-Rivkin T,Liubomirski Y,Bernstein B,Meshel T,Ben-Baruch A
300-01A was used in In vitro experiments to reveal novel pathways through which the inflammatory microenvironment may contribute to relapsed disease in breast cancer.
Sun Dec 01 00:00:00 UTC 2013
Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT₂ and CysLT₁ receptors.
Scientific reports
Duah E,Adapala RK,Al-Azzam N,Kondeti V,Gombedza F,Thodeti CK,Paruchuri S
Wed Nov 20 00:00:00 UTC 2013
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
The Journal of biological chemistry
Basset A,Zhang F,Benes C,Sayeed S,Herd M,Thompson C,Golenbock DT,Camilli A,Malley R
Fri Jan 25 00:00:00 UTC 2013
Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.
The Journal of biological chemistry
Lin H,Trejo J
Fri Apr 19 00:00:00 UTC 2013
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Nature
Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T
Thu Oct 18 00:00:00 UTC 2012
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.
Nature
Sanada T,Kim M,Mimuro H,Suzuki M,Ogawa M,Oyama A,Ashida H,Kobayashi T,Koyama T,Nagai S,Shibata Y,Gohda J,Inoue J,Mizushima T,Sasakawa C
Sun Mar 11 00:00:00 UTC 2012
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling.
Nature methods
Sims JJ,Scavone F,Cooper EM,Kane LA,Youle RJ,Boeke JD,Cohen RE
Sun Feb 05 00:00:00 UTC 2012
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
Blood
Gupta M,Maurer MJ,Wellik LE,Law ME,Han JJ,Ozsan N,Micallef IN,Dogan A,Witzig TE
Thu Nov 22 00:00:00 UTC 2012
Dasatinib inhibits proinflammatory functions of mature human neutrophils.
Blood
Futosi K,Németh T,Pick R,Vántus T,Walzog B,Mócsai A
Thu May 24 00:00:00 UTC 2012
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).
Blood
Xie Z,Ghosh CC,Patel R,Iwaki S,Gaskins D,Nelson C,Jones N,Greipp PR,Parikh SM,Druey KM
Thu May 03 00:00:00 UTC 2012
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation.
Blood
Weissmüller S,Semmler LY,Kalinke U,Christians S,Müller-Berghaus J,Waibler Z
Thu Jun 28 00:00:00 UTC 2012
Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function.
Blood
Dannull J,Schneider T,Lee WT,de Rosa N,Tyler DS,Pruitt SK
Thu Mar 29 00:00:00 UTC 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 UTC 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 UTC 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 UTC 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 UTC 2012
MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20).
Proceedings of the National Academy of Sciences of the United States of America
Kim SW,Ramasamy K,Bouamar H,Lin AP,Jiang D,Aguiar RC
Tue May 15 00:00:00 UTC 2012
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F
Tue Nov 06 00:00:00 UTC 2012
Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats.
Journal of biomedical science
Liao PH,Yang HH,Chou PT,Wang MH,Chu PC,Liu HL,Chen LK
Tue Jun 26 00:00:00 UTC 2012
Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system.
Experimental & molecular medicine
Fukaya Y,Kuroda M,Aoyagi Y,Asada S,Kubota Y,Okamoto Y,Nakayama T,Saito Y,Satoh K,Bujo H
Thu May 31 00:00:00 UTC 2012
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Oncogene
Thu YM,Su Y,Yang J,Splittgerber R,Na S,Boyd A,Mosse C,Simons C,Richmond A
Thu May 17 00:00:00 UTC 2012
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Oncogene
Thu YM,Su Y,Yang J,Splittgerber R,Na S,Boyd A,Mosse C,Simons C,Richmond A
Thu May 17 00:00:00 UTC 2012
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Oncogene
Thu YM,Su Y,Yang J,Splittgerber R,Na S,Boyd A,Mosse C,Simons C,Richmond A
Thu May 17 00:00:00 UTC 2012
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
Oncogene
Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J
Thu Aug 02 00:00:00 UTC 2012
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo.
Breast cancer research : BCR
Fleming JM,Miller TC,Kidacki M,Ginsburg E,Stuelten CH,Stewart DA,Troester MA,Vonderhaar BK
Mon Jun 25 00:00:00 UTC 2012
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
The Journal of cell biology
Huveneers S,Oldenburg J,Spanjaard E,van der Krogt G,Grigoriev I,Akhmanova A,Rehmann H,de Rooij J
Mon Mar 05 00:00:00 UTC 2012
Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD
Sun Apr 01 00:00:00 UTC 2012
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 UTC 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 UTC 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 UTC 2013
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
mAbs
Kanakaraj P,Puffer BA,Yao XT,Kankanala S,Boyd E,Shah RR,Wang G,Patel D,Krishnamurthy R,Kaithamana S,Smith RG,LaFleur DW,Barbas CF,Hilbert DM,Kiener PA,Roschke VV
Thu Jan 17 00:00:00 UTC 2013
Mesenchymal stem cells transmigrate between and directly through tumor necrosis factor-α-activated endothelial cells via both leukocyte-like and novel mechanisms.
Stem cells (Dayton, Ohio)
Teo GS,Ankrum JA,Martinelli R,Boetto SE,Simms K,Sciuto TE,Dvorak AM,Karp JM,Carman CV
Thu Nov 01 00:00:00 UTC 2012
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
Journal of molecular medicine (Berlin, Germany)
Eaton A,Nagy E,Pacault M,Fauconnier J,Bäck M
Mon Oct 01 00:00:00 UTC 2012
Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Fernández-Pisonero I,Dueñas AI,Barreiro O,Montero O,Sánchez-Madrid F,García-Rodríguez C
Sat Dec 01 00:00:00 UTC 2012
HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Chihara T,Hashimoto M,Osman A,Hiyoshi-Yoshidomi Y,Suzu I,Chutiwitoonchai N,Hiyoshi M,Okada S,Suzu S
Sun Apr 15 00:00:00 UTC 2012
Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes.
Journal of immunology (Baltimore, Md. : 1950)
Sommaggio R,Cohnen A,Watzl C,Costa C
Thu Mar 01 00:00:00 UTC 2012
Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats.
Journal of immunology (Baltimore, Md. : 1950)
Sun Q,Yang X,Zhong B,Jiao F,Li C,Li D,Lan X,Sun J,Lu S
Sun Apr 01 00:00:00 UTC 2012
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Azcutia V,Stefanidakis M,Tsuboi N,Mayadas T,Croce KJ,Fukuda D,Aikawa M,Newton G,Luscinskas FW
Sat Sep 01 00:00:00 UTC 2012
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Kuckleburg CJ,Tilkens SB,Santoso S,Newman PJ
Thu Mar 01 00:00:00 UTC 2012
IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ryzhakov G,Blazek K,Lai CC,Udalova IA
Thu Nov 15 00:00:00 UTC 2012
APPL1 regulates basal NF-κB activity by stabilizing NIK.
Journal of cell science
Hupalowska A,Pyrzynska B,Miaczynska M
Sat Sep 01 00:00:00 UTC 2012
Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma.
PloS one
Ge X,Lv X,Feng L,Liu X,Gao J,Chen N,Wang X
Tue Nov 27 00:00:00 UTC 2012
Metadherin contributes to the pathogenesis of diffuse large B-cell lymphoma.
PloS one
Ge X,Lv X,Feng L,Liu X,Gao J,Chen N,Wang X
Tue Nov 27 00:00:00 UTC 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 UTC 2012
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.
PloS one
Matta H,Gopalakrishnan R,Graham C,Tolani B,Khanna A,Yi H,Suo Y,Chaudhary PM
Wed Sep 19 00:00:00 UTC 2012
Differential expression of matrix metalloproteases in human fibroblasts with different origins.
Biochemistry research international
Lindner D,Zietsch C,Becher PM,Schulze K,Schultheiss HP,Tschöpe C,Westermann D
Thu Aug 23 00:00:00 UTC 2012
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.
The Journal of biological chemistry
de Kreuk BJ,Anthony EC,Geerts D,Hordijk PL
Fri Dec 21 00:00:00 UTC 2012
The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.
PloS one
Singh H,Hansen TM,Patel N,Brindle NP
Mon May 14 00:00:00 UTC 2012
The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2.
PloS one
Condé C,Rambout X,Lebrun M,Lecat A,Di Valentin E,Dequiedt F,Piette J,Gloire G,Legrand S
Wed Jan 16 00:00:00 UTC 2013
TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.
Clinical & developmental immunology
Straetemans T,van Brakel M,van Steenbergen S,Broertjes M,Drexhage J,Hegmans J,Lambrecht BN,Lamers C,van Der Bruggen P,Coulie PG,Debets R
Fri Mar 01 00:00:00 UTC 2013
Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.
Scientific reports
Cobos Jiménez V,Booiman T,de Taeye SW,van Dort KA,Rits MA,Hamann J,Kootstra NA
Thu Mar 21 00:00:00 UTC 2013
The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.
Cell death & disease
Grunert M,Gottschalk K,Kapahnke J,Gündisch S,Kieser A,Jeremias I
Thu Oct 25 00:00:00 UTC 2012
Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α.
BMC cancer
Ceran C,Cokol M,Cingoz S,Tasan I,Ozturk M,Yagci T
Thu Oct 04 00:00:00 UTC 2012
Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening.
The Journal of biological chemistry
Lieder F,Reisen F,Geppert T,Sollberger G,Beer HD,auf dem Keller U,Schäfer M,Detmar M,Schneider G,Werner S
Fri Sep 21 00:00:00 UTC 2012
ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
The Journal of biological chemistry
Wilhelmsen K,Mesa KR,Lucero J,Xu F,Hellman J
Fri Aug 03 00:00:00 UTC 2012
IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
The Journal of biological chemistry
Bachmann M,Scheiermann P,Härdle L,Pfeilschifter J,Mühl H
Fri Dec 07 00:00:00 UTC 2012
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.
PloS one
Zhao T,Gao S,Wang X,Liu J,Duan Y,Yuan Z,Sheng J,Li S,Wang F,Yu M,Ren H,Hao J
Tue Feb 19 00:00:00 UTC 2013
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
PloS one
Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E
Tue Mar 05 00:00:00 UTC 2013
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
The Journal of biological chemistry
Le Goff A,Ji Z,Leclercq B,Bourette RP,Mougel A,Guerardel C,de Launoit Y,Vicogne J,Goormachtigh G,Fafeur V
Fri Oct 12 00:00:00 UTC 2012
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
PloS one
Jensen H,Folkersen L,Skov S
Tue Feb 19 00:00:00 UTC 2013
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.
Molecular systems biology
Tentner AR,Lee MJ,Ostheimer GJ,Samson LD,Lauffenburger DA,Yaffe MB
Tue Jan 31 00:00:00 UTC 2012
Decreased expression of vitamin D receptors in neointimal lesions following coronary artery angioplasty in atherosclerotic swine.
PloS one
Gupta GK,Agrawal T,Del Core MG,Hunter WJ,Agrawal DK
Thu Jan 10 00:00:00 UTC 2013
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.
Cancers
Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A
300-01A was used in Cell Culture to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.
Fri Jan 20 00:00:00 UTC 2012
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.
Cancers
Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A
300-01A was used in Cell Culture to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.
Fri Jan 20 00:00:00 UTC 2012
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 UTC 2012
Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade.
PloS one
Rossaint J,Berger C,Van Aken H,Scheld HH,Zahn PK,Rukosujew A,Zarbock A
Thu Mar 28 00:00:00 UTC 2013
Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.
Scientific reports
Antoon JW,Lai R,Struckhoff AP,Nitschke AM,Elliott S,Martin EC,Rhodes LV,Yoon NS,Salvo VA,Shan B,Beckman BS,Nephew KP,Burow ME
Sun Mar 17 00:00:00 UTC 2013
The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma.
PloS one
Kanitz A,Imig J,Dziunycz PJ,Primorac A,Galgano A,Hofbauer GF,Gerber AP,Detmar M
300-01A was used in Sample Preparation (ELISA) to identify a new miRNA recognition element in a downstream conserved region of the vascular endothelial growth factor A (VEGFA) 3'-UTR to show that miR-361-5p levels are inversely correlated with VEGFA expression in SCC and in healthy skin, indicating that miR-361-5p could play a role in cancers.
Thu Jun 20 00:00:00 UTC 2013
The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma.
PloS one
Kanitz A,Imig J,Dziunycz PJ,Primorac A,Galgano A,Hofbauer GF,Gerber AP,Detmar M
300-01A was used in Sample Preparation (ELISA) to identify a new miRNA recognition element in a downstream conserved region of the vascular endothelial growth factor A (VEGFA) 3'-UTR to show that miR-361-5p levels are inversely correlated with VEGFA expression in SCC and in healthy skin, indicating that miR-361-5p could play a role in cancers.
Thu Jun 20 00:00:00 UTC 2013
The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process.
The Journal of biological chemistry
Lecat A,Di Valentin E,Somja J,Jourdan S,Fillet M,Kufer TA,Habraken Y,Sadzot C,Louis E,Delvenne P,Piette J,Legrand-Poels S
Fri Aug 24 00:00:00 UTC 2012
Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade.
PloS one
Zhuo J,Tan EH,Yan B,Tochhawng L,Jayapal M,Koh S,Tay HK,Maciver SK,Hooi SC,Salto-Tellez M,Kumar AP,Goh YC,Lim YC,Yap CT
Tue Jan 29 00:00:00 UTC 2013
Non-apoptotic role of BID in inflammation and innate immunity.
Nature
Yeretssian G,Correa RG,Doiron K,Fitzgerald P,Dillon CP,Green DR,Reed JC,Saleh M
Thu Jun 02 00:00:00 UTC 2011
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.
Nature
Rayner KJ,Esau CC,Hussain FN,McDaniel AL,Marshall SM,van Gils JM,Ray TD,Sheedy FJ,Goedeke L,Liu X,Khatsenko OG,Kaimal V,Lees CJ,Fernandez-Hernando C,Fisher EA,Temel RE,Moore KJ
Wed Oct 19 00:00:00 UTC 2011
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 UTC 2011
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity
Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A
Fri Dec 23 00:00:00 UTC 2011
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.
European heart journal
Brokopp CE,Schoenauer R,Richards P,Bauer S,Lohmann C,Emmert MY,Weber B,Winnik S,Aikawa E,Graves K,Genoni M,Vogt P,Lüscher TF,Renner C,Hoerstrup SP,Matter CM
Tue Nov 01 00:00:00 UTC 2011
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.
Annals of the rheumatic diseases
Valdes AM,De Wilde G,Doherty SA,Lories RJ,Vaughn FL,Laslett LL,Maciewicz RA,Soni A,Hart DJ,Zhang W,Muir KR,Dennison EM,Wheeler M,Leaverton P,Cooper C,Spector TD,Cicuttini FM,Chapman V,Jones G,Arden NK,Doherty M
Thu Sep 01 00:00:00 UTC 2011
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity.
Blood
Sakakibara K,Saito N,Sato T,Suzuki A,Hasegawa Y,Friedman JM,Kufe DW,Vonhoff DD,Iwami T,Kawabe T
Thu Oct 06 00:00:00 UTC 2011
The CX3C chemokine fractalkine mediates platelet adhesion via the von Willebrand receptor glycoprotein Ib.
Blood
Meyer dos Santos S,Klinkhardt U,Scholich K,Nelson K,Monsefi N,Deckmyn H,Kuczka K,Zorn A,Harder S
Thu May 05 00:00:00 UTC 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 UTC 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 UTC 2011
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Blood
Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L
Thu Mar 03 00:00:00 UTC 2011
The tetraspanin CD9 regulates migration, adhesion, and homing of human cord blood CD34+ hematopoietic stem and progenitor cells.
Blood
Leung KT,Chan KY,Ng PC,Lau TK,Chiu WM,Tsang KS,Li CK,Kong CK,Li K
Thu Feb 10 00:00:00 UTC 2011
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Blood
Camous L,Roumenina L,Bigot S,Brachemi S,Frémeaux-Bacchi V,Lesavre P,Halbwachs-Mecarelli L
Thu Jan 27 00:00:00 UTC 2011
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.
Blood
Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P
Thu Apr 14 00:00:00 UTC 2011
Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease.
Blood
Oh U,McCormick MJ,Datta D,Turner RV,Bobb K,Monie DD,Sliskovic DR,Tanaka Y,Zhang J,Meshulam J,Jacobson S
Thu Mar 24 00:00:00 UTC 2011
Monocytes from HTLV-1-infected patients are unable to fully mature into dendritic cells.
Blood
Nascimento CR,Lima MA,de Andrada Serpa MJ,Espindola O,Leite AC,Echevarria-Lima J
Thu Jan 13 00:00:00 UTC 2011
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.
Nucleic acids research
Morikawa M,Koinuma D,Tsutsumi S,Vasilaki E,Kanki Y,Heldin CH,Aburatani H,Miyazono K
Tue Nov 01 00:00:00 UTC 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
Tue Mar 01 00:00:00 UTC 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
Tue Mar 01 00:00:00 UTC 2011
TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Yarilina A,Xu K,Chen J,Ivashkiv LB
Tue Jan 25 00:00:00 UTC 2011
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.
Journal of the National Cancer Institute
Ai J,Tang Q,Wu Y,Xu Y,Feng T,Zhou R,Chen Y,Gao X,Zhu Q,Yue X,Pan Q,Xu S,Li J,Huang M,Daugherty-Holtrop J,He Y,Xu HE,Fan J,Ding J,Geng M
Wed Nov 16 00:00:00 UTC 2011
Ambient particulate matter induces interleukin-8 expression through an alternative NF-κB (nuclear factor-kappa B) mechanism in human airway epithelial cells.
Environmental health perspectives
Silbajoris R,Osornio-Vargas AR,Simmons SO,Reed W,Bromberg PA,Dailey LA,Samet JM
Sat Oct 01 00:00:00 UTC 2011
Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Lu X,Beck GR,Gilbert LC,Camalier CE,Bateman NW,Hood BL,Conrads TP,Kern MJ,You S,Chen H,Nanes MS
Sat Jan 01 00:00:00 UTC 2011
Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway.
Arthritis research & therapy
Ulivi V,Lenti M,Gentili C,Marcolongo G,Cancedda R,Descalzi Cancedda F
Fri Jun 17 00:00:00 UTC 2011
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950)
Kim YJ,Park SJ,Broxmeyer HE
Thu Sep 01 00:00:00 UTC 2011
Cytotoxic dendritic cells generated from cancer patients.
Journal of immunology (Baltimore, Md. : 1950)
Lakomy D,Janikashvili N,Fraszczak J,Trad M,Audia S,Samson M,Ciudad M,Vinit J,Vergely C,Caillot D,Foucher P,Lagrost L,Chouaib S,Katsanis E,Larmonier N,Bonnotte B
Thu Sep 01 00:00:00 UTC 2011
Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Young TW,Straub C,Stafford S,Kurosky A
Wed Jun 01 00:00:00 UTC 2011
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Journal of immunology (Baltimore, Md. : 1950)
Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH
Fri Apr 01 00:00:00 UTC 2011
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Ansari NA,Kumar R,Gautam S,Nylén S,Singh OP,Sundar S,Sacks D
Fri Apr 01 00:00:00 UTC 2011
Endogenous cortisol and TGF-beta in human aqueous humor contribute to ocular immune privilege by regulating dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Denniston AK,Kottoor SH,Khan I,Oswal K,Williams GP,Abbott J,Wallace GR,Salmon M,Rauz S,Murray PI,Curnow SJ
Sat Jan 01 00:00:00 UTC 2011
An evolutionarily conserved TNF-alpha-responsive enhancer in the far upstream region of human CCL2 locus influences its gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Bonello GB,Pham MH,Begum K,Sigala J,Sataranatarajan K,Mummidi S
Wed Jun 15 00:00:00 UTC 2011
Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K
Tue Feb 01 00:00:00 UTC 2011
Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).
Journal of ethnopharmacology
Schwaiger S,Zeller I,Pölzelbauer P,Frotschnig S,Laufer G,Messner B,Pieri V,Stuppner H,Bernhard D
Thu Jan 27 00:00:00 UTC 2011
Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).
Journal of ethnopharmacology
Schwaiger S,Zeller I,Pölzelbauer P,Frotschnig S,Laufer G,Messner B,Pieri V,Stuppner H,Bernhard D
Thu Jan 27 00:00:00 UTC 2011
Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.
Experimental cell research
Burton VJ,Butler LM,McGettrick HM,Stone PC,Jeffery HC,Savage CO,Rainger GE,Nash GB
Tue Feb 01 00:00:00 UTC 2011
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Bioorganic & medicinal chemistry
Grienke U,Mihály-Bison J,Schuster D,Afonyushkin T,Binder M,Guan SH,Cheng CR,Wolber G,Stuppner H,Guo DA,Bochkov VN,Rollinger JM
Tue Nov 15 00:00:00 UTC 2011
A novel TLR3 inhibitor encoded by African swine fever virus (ASFV).
Archives of virology
de Oliveira VL,Almeida SC,Soares HR,Crespo A,Marshall-Clarke S,Parkhouse RM
Fri Apr 01 00:00:00 UTC 2011
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.
BMC genomics
Wang Z,Bishop EP,Burke PA
Fri Feb 25 00:00:00 UTC 2011
Utilizing mitochondrial events as biomarkers for imaging apoptosis.
Cell death & disease
Yivgi-Ohana N,Eifer M,Addadi Y,Neeman M,Gross A
Thu Jun 02 00:00:00 UTC 2011
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
PloS one
Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S
Fri Apr 29 00:00:00 UTC 2011
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.
PloS one
Aldhous MC,Soo K,Stark LA,Ulanicka AA,Easterbrook JE,Dunlop MG,Satsangi J
Tue Feb 28 00:00:00 UTC 2012
Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.
Molecular & cellular proteomics : MCP
Reis CR,van Assen AH,Quax WJ,Cool RH
Sat Jan 01 00:00:00 UTC 2011
The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide.
Clinical & developmental immunology
Tan G,Zhang X,Feng H,Luo H,Wang Z
Wed Jun 06 00:00:00 UTC 2012
Azadirachtin interacts with retinoic acid receptors and inhibits retinoic acid-mediated biological responses.
The Journal of biological chemistry
Thoh M,Babajan B,Raghavendra PB,Sureshkumar C,Manna SK
Fri Feb 11 00:00:00 UTC 2011
Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.
Journal of inflammation (London, England)
Asp L,Johansson AS,Mann A,Owe-Larsson B,Urbanska EM,Kocki T,Kegel M,Engberg G,Lundkvist GB,Karlsson H
Sat Oct 08 00:00:00 UTC 2011
Binding of albumin promotes bacterial survival at the epithelial surface.
The Journal of biological chemistry
Egesten A,Frick IM,Mörgelin M,Olin AI,Björck L
Fri Jan 28 00:00:00 UTC 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 UTC 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 UTC 2011
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.
The Journal of biological chemistry
Benfield CT,Mansur DS,McCoy LE,Ferguson BJ,Bahar MW,Oldring AP,Grimes JM,Stuart DI,Graham SC,Smith GL
Fri Jun 10 00:00:00 UTC 2011
Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.
PLoS neglected tropical diseases
Castro de Moura M,Miro F,Han JM,Kim S,Celada A,Ribas de Pouplana L
Tue Nov 01 00:00:00 UTC 2011
Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS.
Journal of neuroinflammation
Cao S,Wu C,Yang Y,Sniderhan LF,Maggirwar SB,Dewhurst S,Lu Y
Sat May 14 00:00:00 UTC 2011
Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells.
Journal of neuroinflammation
Dao MA,Tate CC,Aizman I,McGrogan M,Case CC
Fri Oct 07 00:00:00 UTC 2011
Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.
PloS one
de Jong E,Winkel P,Poelstra K,Prakash J
Fri Feb 03 00:00:00 UTC 2012
Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.
Molecular systems biology
Aldridge BB,Gaudet S,Lauffenburger DA,Sorger PK
Tue Nov 22 00:00:00 UTC 2011
A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.
BMC complementary and alternative medicine
Freise C,Ruehl M,Erben U,Neumann U,Seehofer D,Kim KY,Trowitzsch-Kienast W,Stroh T,Zeitz M,Somasundaram R
Thu May 12 00:00:00 UTC 2011
Evolutionary conserved regulation of HIF-1β by NF-κB.
PLoS genetics
van Uden P,Kenneth NS,Webster R,Müller HA,Mudie S,Rocha S
Thu Jan 27 00:00:00 UTC 2011
The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes.
The Journal of biological chemistry
Lo Buono N,Parrotta R,Morone S,Bovino P,Nacci G,Ortolan E,Horenstein AL,Inzhutova A,Ferrero E,Funaro A
Fri May 27 00:00:00 UTC 2011
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one
Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B
Tue Feb 14 00:00:00 UTC 2012
Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.
PloS one
Bess E,Fisslthaler B,Frömel T,Fleming I
Fri Sep 30 00:00:00 UTC 2011
Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria.
PloS one
Barbier M,Faille D,Loriod B,Textoris J,Camus C,Puthier D,Flori L,Wassmer SC,Victorero G,Alessi MC,Fusaï T,Nguyen C,Grau GE,Rihet P
Fri Oct 21 00:00:00 UTC 2011
CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
BMC immunology
Wang XB,Fan ZZ,Anton D,Vollenhoven AV,Ni ZH,Chen XF,Lefvert AK
Fri Mar 18 00:00:00 UTC 2011
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
The Journal of biological chemistry
Jenkins RW,Clarke CJ,Canals D,Snider AJ,Gault CR,Heffernan-Stroud L,Wu BX,Simbari F,Roddy P,Kitatani K,Obeid LM,Hannun YA
Fri Apr 15 00:00:00 UTC 2011
Detection and monitoring of the multiple inflammatory responses by photoacoustic molecular imaging using selectively targeted gold nanorods.
Biomedical optics express
Ha S,Carson A,Agarwal A,Kotov NA,Kim K
Wed Feb 23 00:00:00 UTC 2011
ST2 and IL-33 in pregnancy and pre-eclampsia.
PloS one
Granne I,Southcombe JH,Snider JV,Tannetta DS,Child T,Redman CW,Sargent IL
Fri Feb 03 00:00:00 UTC 2012
Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation.
The Journal of biological chemistry
Wang Y,Robertson JD,Walcheck B
Fri Nov 11 00:00:00 UTC 2011
IκB kinase β regulates epithelium migration during corneal wound healing.
PloS one
Chen L,Meng Q,Kao W,Xia Y
Mon Jan 17 00:00:00 UTC 2011
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
PloS one
An H,Lu X,Liu D,Yarbrough WG
Mon Jan 24 00:00:00 UTC 2011
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Journal of neuroinflammation
Green JA,Dholakia S,Janczar K,Ong CW,Moores R,Fry J,Elkington PT,Roncaroli F,Friedland JS
Wed May 11 00:00:00 UTC 2011
The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.
PloS one
Vandevenne P,Lebrun M,El Mjiyad N,Ote I,Di Valentin E,Habraken Y,Dortu E,Piette J,Sadzot-Delvaux C
Wed Feb 09 00:00:00 UTC 2011
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.
The Journal of biological chemistry
Li J,Wang JJ,Zhang SX
Fri Feb 11 00:00:00 UTC 2011
Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef.
Retrovirology
Coleman CM,Spearman P,Wu L
Tue Apr 19 00:00:00 UTC 2011
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.
The Journal of biological chemistry
Mullen TD,Jenkins RW,Clarke CJ,Bielawski J,Hannun YA,Obeid LM
Fri May 06 00:00:00 UTC 2011
The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.
The Journal of biological chemistry
Stempin CC,Chi L,Giraldo-Vela JP,High AA,Häcker H,Redecke V
Fri Oct 28 00:00:00 UTC 2011
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
The Journal of biological chemistry
Lobito AA,Ramani SR,Tom I,Bazan JF,Luis E,Fairbrother WJ,Ouyang W,Gonzalez LC
Fri May 27 00:00:00 UTC 2011
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Cell
Radoshevich L,Murrow L,Chen N,Fernandez E,Roy S,Fung C,Debnath J
Fri Aug 20 00:00:00 UTC 2010
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 UTC 2010
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.
Immunity
Blanchet FP,Moris A,Nikolic DS,Lehmann M,Cardinaud S,Stalder R,Garcia E,Dinkins C,Leuba F,Wu L,Schwartz O,Deretic V,Piguet V
Fri May 28 00:00:00 UTC 2010
Evidence for a cross-talk between human neutrophils and Th17 cells.
Blood
Pelletier M,Maggi L,Micheletti A,Lazzeri E,Tamassia N,Costantini C,Cosmi L,Lunardi C,Annunziato F,Romagnani S,Cassatella MA
Thu Jan 14 00:00:00 UTC 2010
Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis.
Blood
Marcondes AM,Li X,Gooley TA,Milless B,Deeg HJ
Thu Mar 11 00:00:00 UTC 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 UTC 2010
The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes.
Blood
Li X,Marcondes AM,Gooley TA,Deeg HJ
Thu Sep 30 00:00:00 UTC 2010
The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.
Blood
Boussetta T,Gougerot-Pocidalo MA,Hayem G,Ciappelloni S,Raad H,Arabi Derkawi R,Bournier O,Kroviarski Y,Zhou XZ,Malter JS,Lu PK,Bartegi A,Dang PM,El-Benna J
Thu Dec 23 00:00:00 UTC 2010
Fibrinolytic cross-talk: a new mechanism for plasmin formation.
Blood
Dejouvencel T,Doeuvre L,Lacroix R,Plawinski L,Dignat-George F,Lijnen HR,Anglés-Cano E
Thu Mar 11 00:00:00 UTC 2010
GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death.
Blood
Streetly MJ,Maharaj L,Joel S,Schey SA,Gribben JG,Cotter FE
Thu May 13 00:00:00 UTC 2010
Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes.
Blood
Drewniak A,Tool AT,Geissler J,van Bruggen R,van den Berg TK,Kuijpers TW
Thu Jun 03 00:00:00 UTC 2010
LOX-1 as a natural IFN-alpha-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells.
Blood
Parlato S,Romagnoli G,Spadaro F,Canini I,Sirabella P,Borghi P,Ramoni C,Filesi I,Biocca S,Gabriele L,Belardelli F
Thu Feb 25 00:00:00 UTC 2010
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.
Proceedings of the National Academy of Sciences of the United States of America
Pastorelli L,Garg RR,Hoang SB,Spina L,Mattioli B,Scarpa M,Fiocchi C,Vecchi M,Pizarro TT
Tue Apr 27 00:00:00 UTC 2010
Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Proceedings of the National Academy of Sciences of the United States of America
Krishnamoorthy S,Recchiuti A,Chiang N,Yacoubian S,Lee CH,Yang R,Petasis NA,Serhan CN
Tue Jan 26 00:00:00 UTC 2010
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Proceedings of the National Academy of Sciences of the United States of America
Núñez V,Alameda D,Rico D,Mota R,Gonzalo P,Cedenilla M,Fischer T,Boscá L,Glass CK,Arroyo AG,Ricote M
Tue Jun 08 00:00:00 UTC 2010
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.
PLoS pathogens
Bachmann M,Horn K,Rudloff I,Goren I,Holdener M,Christen U,Darsow N,Hunfeld KP,Koehl U,Kind P,Pfeilschifter J,Kraiczy P,Mühl H
Thu Oct 14 00:00:00 UTC 2010
Marburg virus evades interferon responses by a mechanism distinct from ebola virus.
PLoS pathogens
Valmas C,Grosch MN,Schümann M,Olejnik J,Martinez O,Best SM,Krähling V,Basler CF,Mühlberger E
Fri Jan 15 00:00:00 UTC 2010
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.
Arthritis research & therapy
Quan LD,Purdue PE,Liu XM,Boska MD,Lele SM,Thiele GM,Mikuls TR,Dou H,Goldring SR,Wang D
Thu Mar 31 00:00:00 UTC 2011
A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.
Arthritis research & therapy
Scotto d'Abusco A,Politi L,Giordano C,Scandurra R
Fri Aug 13 00:00:00 UTC 2010
The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Takao S,Ishikawa T,Yamashita K,Uchiyama T
Mon Nov 15 00:00:00 UTC 2010
Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling.
Journal of immunology (Baltimore, Md. : 1950)
Labbé K,Miu J,Yeretssian G,Serghides L,Tam M,Finney CA,Erdman LK,Goulet ML,Kain KC,Stevenson MM,Saleh M
Mon Nov 01 00:00:00 UTC 2010
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
Journal of immunology (Baltimore, Md. : 1950)
Ho AW,Shen F,Conti HR,Patel N,Childs EE,Peterson AC,Hernández-Santos N,Kolls JK,Kane LP,Ouyang W,Gaffen SL
Thu Jul 15 00:00:00 UTC 2010
The microtubule regulator stathmin is an endogenous protein agonist for TLR3.
Journal of immunology (Baltimore, Md. : 1950)
Bsibsi M,Bajramovic JJ,Vogt MH,van Duijvenvoorden E,Baghat A,Persoon-Deen C,Tielen F,Verbeek R,Huitinga I,Ryffel B,Kros A,Gerritsen WH,Amor S,van Noort JM
Tue Jun 15 00:00:00 UTC 2010
Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.
Journal of immunology (Baltimore, Md. : 1950)
Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J
Wed Dec 01 00:00:00 UTC 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 UTC 2010
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Journal of immunology (Baltimore, Md. : 1950)
Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH
Mon Mar 15 00:00:00 UTC 2010
Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Shan L,Redhu NS,Saleh A,Halayko AJ,Chakir J,Gounni AS
Tue Jun 15 00:00:00 UTC 2010
The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
Journal of immunology (Baltimore, Md. : 1950)
James DE,Nestor BJ,Sculco TP,Ivashkiv LB,Ross FP,Goldring SR,Purdue PE
Thu Jul 15 00:00:00 UTC 2010
The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.
Journal of immunology (Baltimore, Md. : 1950)
Thacker SG,Berthier CC,Mattinzoli D,Rastaldi MP,Kretzler M,Kaplan MJ
Fri Oct 01 00:00:00 UTC 2010
Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Matsuzaki S,Ishizuka T,Hisada T,Aoki H,Komachi M,Ichimonji I,Utsugi M,Ono A,Koga Y,Dobashi K,Kurose H,Tomura H,Mori M,Okajima F
Fri Oct 15 00:00:00 UTC 2010
Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
Journal of immunology (Baltimore, Md. : 1950)
Kalliolias GD,Gordon RA,Ivashkiv LB
Wed Dec 01 00:00:00 UTC 2010
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.
Journal of immunology (Baltimore, Md. : 1950)
Green JA,Elkington PT,Pennington CJ,Roncaroli F,Dholakia S,Moores RC,Bullen A,Porter JC,Agranoff D,Edwards DR,Friedland JS
Tue Jun 01 00:00:00 UTC 2010
Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration.
Tissue engineering. Part A
Giannoni P,Scaglione S,Daga A,Ilengo C,Cilli M,Quarto R
Mon Feb 01 00:00:00 UTC 2010
Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.
Molecular cancer
Valentine R,Dawson CW,Hu C,Shah KM,Owen TJ,Date KL,Maia SP,Shao J,Arrand JR,Young LS,O'Neil JD
Tue Jan 05 00:00:00 UTC 2010
BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.
The Journal of biological chemistry
Keutgens A,Zhang X,Shostak K,Robert I,Olivier S,Vanderplasschen A,Chapelle JP,Viatour P,Merville MP,Bex F,Gothot A,Chariot A
Fri Aug 13 00:00:00 UTC 2010
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells.
The Journal of biological chemistry
Pruessmeyer J,Martin C,Hess FM,Schwarz N,Schmidt S,Kogel T,Hoettecke N,Schmidt B,Sechi A,Uhlig S,Ludwig A
Fri Jan 01 00:00:00 UTC 2010
Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1.
The Journal of biological chemistry
Manna SK,Babajan B,Raghavendra PB,Raviprakash N,Sureshkumar C
Fri Apr 09 00:00:00 UTC 2010
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
PloS one
Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M
Thu Mar 18 00:00:00 UTC 2010
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.
Molecular & cellular proteomics : MCP
Alexopoulos LG,Saez-Rodriguez J,Cosgrove BD,Lauffenburger DA,Sorger PK
Wed Sep 01 00:00:00 UTC 2010
KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
The Journal of biological chemistry
Tago K,Funakoshi-Tago M,Sakinawa M,Mizuno N,Itoh H
Fri Oct 01 00:00:00 UTC 2010
MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization.
The Journal of biological chemistry
Jennewein C,von Knethen A,Schmid T,Brüne B
Fri Apr 16 00:00:00 UTC 2010
Inhibition of protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.
The Journal of biological chemistry
Subramanyam M,Takahashi N,Hasegawa Y,Mohri T,Okada Y
Fri Feb 26 00:00:00 UTC 2010
Correlation of NF-kappaB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma.
BMC cancer
Yan M,Xu Q,Zhang P,Zhou XJ,Zhang ZY,Chen WT
Tue Aug 17 00:00:00 UTC 2010
Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium.
PloS one
van Buul JD,van Rijssel J,van Alphen FP,Hoogenboezem M,Tol S,Hoeben KA,van Marle J,Mul EP,Hordijk PL
Mon Jun 28 00:00:00 UTC 2010
Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Molecular pain
Chen T,Koga K,Li XY,Zhuo M
Fri Apr 09 00:00:00 UTC 2010
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.
The Journal of biological chemistry
Meshki J,Caino MC,von Burstin VA,Griner E,Kazanietz MG
Fri Aug 20 00:00:00 UTC 2010
Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
The Journal of biological chemistry
Jenkins RW,Canals D,Idkowiak-Baldys J,Simbari F,Roddy P,Perry DM,Kitatani K,Luberto C,Hannun YA
Fri Nov 12 00:00:00 UTC 2010
Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand.
PloS one
Humphreys EH,Williams KT,Adams DH,Afford SC
Wed Nov 17 00:00:00 UTC 2010
Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts.
The Journal of biological chemistry
Majewski PM,Thurston RD,Ramalingam R,Kiela PR,Ghishan FK
Fri Nov 05 00:00:00 UTC 2010
Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl.
Molecular cancer
Lu Z,Jin Y,Chen C,Li J,Cao Q,Pan J
Wed May 19 00:00:00 UTC 2010
Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer.
PloS one
Stuelten CH,Busch JI,Tang B,Flanders KC,Oshima A,Sutton E,Karpova TS,Roberts AB,Wakefield LM,Niederhuber JE
Tue Mar 23 00:00:00 UTC 2010
Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.
The Journal of biological chemistry
Thoh M,Kumar P,Nagarajaram HA,Manna SK
Fri Feb 19 00:00:00 UTC 2010
Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.
Journal of inflammation (London, England)
Jensen SS,Gad M
Tue Jul 27 00:00:00 UTC 2010
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study.
Molecular cancer
Psallidas I,Karabela SP,Moschos C,Sherrill TP,Kollintza A,Magkouta S,Theodoropoulou P,Roussos C,Blackwell TS,Kalomenidis I,Stathopoulos GT
Wed Mar 10 00:00:00 UTC 2010
Induction by TNF-α of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads.
Journal of biomedicine & biotechnology
Borgatti M,Mazzitelli S,Breveglieri G,Gambari R,Nastruzzi C
Fri Jan 28 00:00:00 UTC 2011
Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.
PloS one
Baron RM,Lopez-Guzman S,Riascos DF,Macias AA,Layne MD,Cheng G,Harris C,Chung SW,Reeves R,von Andrian UH,Perrella MA
Fri May 14 00:00:00 UTC 2010
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
The Journal of biological chemistry
Humphrey RK,Newcomb CJ,Yu SM,Hao E,Yu D,Krajewski S,Du K,Jhala US
Fri Jul 16 00:00:00 UTC 2010
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.
Nature communications
Aichem A,Pelzer C,Lukasiak S,Kalveram B,Sheppard PW,Rani N,Schmidtke G,Groettrup M
Tue May 04 00:00:00 UTC 2010
Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.
Blood
Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H
Thu Oct 29 00:00:00 UTC 2009
Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages.
Blood
Ballana E,Pauls E,Senserrich J,Clotet B,Perron-Sierra F,Tucker GC,Esté JA
Thu Feb 05 00:00:00 UTC 2009
An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.
Blood
Trinidad EM,Ballesteros M,Zuloaga J,Zapata A,Alonso-Colmenar LM
Thu Dec 03 00:00:00 UTC 2009
C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function.
Blood
Bossi F,Rizzi L,Bulla R,Debeus A,Tripodo C,Picotti P,Betto E,Macor P,Pucillo C,Würzner R,Tedesco F
Thu Apr 09 00:00:00 UTC 2009
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Blood
Fang HY,Hughes R,Murdoch C,Coffelt SB,Biswas SK,Harris AL,Johnson RS,Imityaz HZ,Simon MC,Fredlund E,Greten FR,Rius J,Lewis CE
Thu Jul 23 00:00:00 UTC 2009
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Blood
Koenen RR,Pruessmeyer J,Soehnlein O,Fraemohs L,Zernecke A,Schwarz N,Reiss K,Sarabi A,Lindbom L,Hackeng TM,Weber C,Ludwig A
Thu May 07 00:00:00 UTC 2009
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.
Blood
Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC
Thu Feb 12 00:00:00 UTC 2009
Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD.
Blood
Mhyre AJ,Marcondes AM,Spaulding EY,Deeg HJ
Thu Jan 15 00:00:00 UTC 2009
MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines.
Nucleic acids research
Dandrea M,Donadelli M,Costanzo C,Scarpa A,Palmieri M
Sun Nov 01 00:00:00 UTC 2009
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.
The Journal of experimental medicine
Cao W,Bover L,Cho M,Wen X,Hanabuchi S,Bao M,Rosen DB,Wang YH,Shaw JL,Du Q,Li C,Arai N,Yao Z,Lanier LL,Liu YJ
Mon Jul 06 00:00:00 UTC 2009
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.
The Journal of experimental medicine
Haniffa M,Ginhoux F,Wang XN,Bigley V,Abel M,Dimmick I,Bullock S,Grisotto M,Booth T,Taub P,Hilkens C,Merad M,Collin M
Mon Feb 16 00:00:00 UTC 2009
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.
The Journal of experimental medicine
Minegishi Y,Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Karasuyama H
Mon Jun 08 00:00:00 UTC 2009
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice.
The EMBO journal
Marchetti S,Gamas P,Belhacène N,Grosso S,Pradelli LA,Colosetti P,Johansen C,Iversen L,Deckert M,Luciano F,Hofman P,Ortonne N,Khemis A,Mari B,Ortonne JP,Ricci JE,Auberger P
Wed Aug 19 00:00:00 UTC 2009
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y
Tue Sep 15 00:00:00 UTC 2009
Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.
Clinical cancer research : an official journal of the American Association for Cancer Research
Yamashita T,Tamura H,Satoh C,Shinya E,Takahashi H,Chen L,Kondo A,Tsuji T,Dan K,Ogata K
Sun Feb 01 00:00:00 UTC 2009
XIAP mediates NOD signaling via interaction with RIP2.
Proceedings of the National Academy of Sciences of the United States of America
Krieg A,Correa RG,Garrison JB,Le Negrate G,Welsh K,Huang Z,Knoefel WT,Reed JC
Tue Aug 25 00:00:00 UTC 2009
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.
Proceedings of the National Academy of Sciences of the United States of America
Bazzoni F,Rossato M,Fabbri M,Gaudiosi D,Mirolo M,Mori L,Tamassia N,Mantovani A,Cassatella MA,Locati M
Tue Mar 31 00:00:00 UTC 2009
Regulation of pentraxin-3 by antioxidants.
British journal of anaesthesia
Hill AL,Lowes DA,Webster NR,Sheth CC,Gow NA,Galley HF
Tue Dec 01 00:00:00 UTC 2009
A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Locke LW,Chordia MD,Zhang Y,Kundu B,Kennedy D,Landseadel J,Xiao L,Fairchild KD,Berr SS,Linden J,Pan D
Fri May 01 00:00:00 UTC 2009
Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction.
Oncogene
Baritaki S,Chapman A,Yeung K,Spandidos DA,Palladino M,Bonavida B
Thu Oct 08 00:00:00 UTC 2009
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.
PLoS pathogens
Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B
Sun Feb 01 00:00:00 UTC 2009
In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.
Arthritis research & therapy
Pretzel D,Pohlers D,Weinert S,Kinne RW
Wed Sep 09 00:00:00 UTC 2009
Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.
Laboratory investigation; a journal of technical methods and pathology
Chakravarti A,Rusu D,Flamand N,Borgeat P,Poubelle PE
Thu Oct 01 00:00:00 UTC 2009
Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.
Journal of immunology (Baltimore, Md. : 1950)
Breckpot K,Aerts-Toegaert C,Heirman C,Peeters U,Beyaert R,Aerts JL,Thielemans K
Thu Jan 15 00:00:00 UTC 2009
1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Széles L,Keresztes G,Töröcsik D,Balajthy Z,Krenács L,Póliska S,Steinmeyer A,Zuegel U,Pruenster M,Rot A,Nagy L
Sun Feb 15 00:00:00 UTC 2009
Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice.
Journal of immunology (Baltimore, Md. : 1950)
Darcan-Nicolaisen Y,Meinicke H,Fels G,Hegend O,Haberland A,Kühl A,Loddenkemper C,Witzenrath M,Kube S,Henke W,Hamelmann E
Mon Jun 15 00:00:00 UTC 2009
CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
Journal of immunology (Baltimore, Md. : 1950)
Escribano C,Delgado-Martín C,Rodríguez-Fernández JL
Sun Nov 15 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.
Journal of immunology (Baltimore, Md. : 1950)
Montfort A,de Badts B,Douin-Echinard V,Martin PG,Iacovoni J,Nevoit C,Therville N,Garcia V,Bertrand MA,Bessières MH,Trombe MC,Levade T,Benoist H,Ségui B
Thu Oct 15 00:00:00 UTC 2009
MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.
Journal of immunology (Baltimore, Md. : 1950)
Qu C,Nguyen VA,Merad M,Randolph GJ
Sun Mar 15 00:00:00 UTC 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 UTC 2009
c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion.
Journal of immunology (Baltimore, Md. : 1950)
Cui L,Chen C,Xu T,Zhang J,Shang X,Luo J,Chen L,Ba X,Zeng X
Sun Mar 01 00:00:00 UTC 2009
Developmental switch of the expression of ion channels in human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G
Thu Oct 01 00:00:00 UTC 2009
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 UTC 2009
Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA.
Oncology reports
Liu X,Xu Q,Chen W,Cao H,Zheng R,Li G
300-01A was used in Sample Preparation (FC/FACS) to identify a possible novel mechanism that indicates how CpG DNA of HBV DNA may contribute to the malignant transformation of benign liver cells.
Wed Apr 01 00:00:00 UTC 2009
A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury.
PloS one
Santamaría B,Benito-Martin A,Ucero AC,Aroeira LS,Reyero A,Vicent MJ,Orzáez M,Celdrán A,Esteban J,Selgas R,Ruíz-Ortega M,Cabrera ML,Egido J,Pérez-Payá E,Ortiz A
Thu Aug 13 00:00:00 UTC 2009
Bacterial particle endocytosis by epithelial cells is selective and enhanced by tumor necrosis factor receptor ligands.
Clinical and vaccine immunology : CVI
Clark RT,Hope A,Lopez-Fraga M,Schiller N,Lo DD
Sun Mar 01 00:00:00 UTC 2009
The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes.
International journal of biological sciences
van Buul JD,van Alphen FP,Hordijk PL
Mon Nov 09 00:00:00 UTC 2009
Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
The Journal of biological chemistry
Song H,Suehiro J,Kanki Y,Kawai Y,Inoue K,Daida H,Yano K,Ohhashi T,Oettgen P,Aird WC,Kodama T,Minami T
Fri Oct 16 00:00:00 UTC 2009
Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.
The Journal of biological chemistry
Yamazaki M,Fukushima H,Shin M,Katagiri T,Doi T,Takahashi T,Jimi E
Fri Dec 18 00:00:00 UTC 2009
Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.
PloS one
St-Onge M,Dumas A,Michaud A,Laflamme C,Dussault AA,Pouliot M
Thu May 14 00:00:00 UTC 2009
Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins.
The Journal of biological chemistry
Ventura E,Sassi F,Fossati S,Parodi A,Blalock W,Balza E,Castellani P,Borsi L,Carnemolla B,Zardi L
Fri Sep 25 00:00:00 UTC 2009
Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.
The Journal of biological chemistry
Autefage H,Albinet V,Garcia V,Berges H,Nicolau ML,Therville N,Altié MF,Caillaud C,Levade T,Andrieu-Abadie N
Fri Apr 24 00:00:00 UTC 2009
Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.
PloS one
Pothlichet J,Burtey A,Kubarenko AV,Caignard G,Solhonne B,Tangy F,Ben-Ali M,Quintana-Murci L,Heinzmann A,Chiche JD,Vidalain PO,Weber AN,Chignard M,Si-Tahar M
Tue Oct 27 00:00:00 UTC 2009
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Molecular systems biology
Saez-Rodriguez J,Alexopoulos LG,Epperlein J,Samaga R,Lauffenburger DA,Klamt S,Sorger PK
Thu Apr 01 00:00:00 UTC 2010
Interleukin-32 expression in the pancreas.
The Journal of biological chemistry
Nishida A,Andoh A,Inatomi O,Fujiyama Y
Fri Jun 26 00:00:00 UTC 2009
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.
Blood
Nelson EA,Walker SR,Kepich A,Gashin LB,Hideshima T,Ikeda H,Chauhan D,Anderson KC,Frank DA
Mon Dec 15 00:00:00 UTC 2008
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.
The Journal of experimental medicine
Nottebaum AF,Cagna G,Winderlich M,Gamp AC,Linnepe R,Polaschegg C,Filippova K,Lyck R,Engelhardt B,Kamenyeva O,Bixel MG,Butz S,Vestweber D
Mon Nov 24 00:00:00 UTC 2008
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Proceedings of the National Academy of Sciences of the United States of America
Zhu Q,Egelston C,Vivekanandhan A,Uematsu S,Akira S,Klinman DM,Belyakov IM,Berzofsky JA
Tue Oct 21 00:00:00 UTC 2008
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Komarov AP,Rokhlin OW,Yu CA,Gudkov AV
Tue Sep 23 00:00:00 UTC 2008
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.
PLoS pathogens
Chen RA,Ryzhakov G,Cooray S,Randow F,Smith GL
Fri Feb 08 00:00:00 UTC 2008
Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells.
Stem cells (Dayton, Ohio)
Johansson S,Price J,Modo M
Mon Sep 01 00:00:00 UTC 2008
Development and validation of human psoriatic skin equivalents.
The American journal of pathology
Tjabringa G,Bergers M,van Rens D,de Boer R,Lamme E,Schalkwijk J
Mon Sep 01 00:00:00 UTC 2008
B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
Journal of immunology (Baltimore, Md. : 1950)
Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S
Tue Jul 01 00:00:00 UTC 2008
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.
Journal of immunology (Baltimore, Md. : 1950)
Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M
Sun Jun 15 00:00:00 UTC 2008
Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.
Journal of immunology (Baltimore, Md. : 1950)
Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R
Mon Dec 15 00:00:00 UTC 2008
A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.
Journal of immunology (Baltimore, Md. : 1950)
Parker LC,Prestwich EC,Ward JR,Smythe E,Berry A,Triantafilou M,Triantafilou K,Sabroe I
Wed Oct 15 00:00:00 UTC 2008
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Journal of immunology (Baltimore, Md. : 1950)
Hartl D,Krauss-Etschmann S,Koller B,Hordijk PL,Kuijpers TW,Hoffmann F,Hector A,Eber E,Marcos V,Bittmann I,Eickelberg O,Griese M,Roos D
Mon Dec 01 00:00:00 UTC 2008
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry
Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL
Fri May 16 00:00:00 UTC 2008
Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients.
PloS one
Zeeuwen PL,de Jongh GJ,Rodijk-Olthuis D,Kamsteeg M,Verhoosel RM,van Rossum MM,Hiemstra PS,Schalkwijk J
Wed Jun 04 00:00:00 UTC 2008
Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis.
PloS one
Liu DQ,Li LM,Guo YL,Bai R,Wang C,Bian Z,Zhang CY,Zen K
Mon Sep 29 00:00:00 UTC 2008
Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells.
BMC immunology
Weingart C,Nelson PJ,Krämer BK,Mack M
Wed Dec 10 00:00:00 UTC 2008
Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
Arthritis and rheumatism
Sawaji Y,Hynes J,Vincent T,Saklatvala J
Sat Nov 01 00:00:00 UTC 2008
A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.
Blood
Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Sat Sep 15 00:00:00 UTC 2007
Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kramer JM,Hanel W,Shen F,Isik N,Malone JP,Maitra A,Sigurdson W,Swart D,Tocker J,Jin T,Gaffen SL
Thu Nov 15 00:00:00 UTC 2007
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Cassatella MA,Pereira-da-Silva G,Tinazzi I,Facchetti F,Scapini P,Calzetti F,Tamassia N,Wei P,Nardelli B,Roschke V,Vecchi A,Mantovani A,Bambara LM,Edwards SW,Carletto A
Fri Jun 01 00:00:00 UTC 2007
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 UTC 2006
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
Journal of immunology (Baltimore, Md. : 1950)
Eksteen B,Miles A,Curbishley SM,Tselepis C,Grant AJ,Walker LS,Adams DH
Sat Jul 01 00:00:00 UTC 2006
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M
Wed Nov 01 00:00:00 UTC 2006
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Chiu WK,Fann M,Weng NP
Fri Dec 01 00:00:00 UTC 2006
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Chiu WK,Fann M,Weng NP
Fri Dec 01 00:00:00 UTC 2006
Skin-derived micro-organs induce angiogenesis in rabbits.
Journal of vascular research
Hasson E,Gallula J,Shimoni Y,Grad-Itach E,Marikovsky M,Mitrani E
Thu Mar 16 00:00:00 UTC 2006
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.
American journal of respiratory and critical care medicine
Morris GE,Whyte MK,Martin GF,Jose PJ,Dower SK,Sabroe I
Fri Apr 15 00:00:00 UTC 2005
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments.
Journal of immunology (Baltimore, Md. : 1950)
Pulai JI,Chen H,Im HJ,Kumar S,Hanning C,Hegde PS,Loeser RF
Sun May 01 00:00:00 UTC 2005
Monocyte-astrocyte networks and the regulation of chemokine secretion in neurocysticercosis.
Journal of immunology (Baltimore, Md. : 1950)
Uddin J,Garcia HH,Gilman RH,Gonzalez AE,Friedland JS
Thu Sep 01 00:00:00 UTC 2005
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.
The Journal of biological chemistry
Lora JM,Zhang DM,Liao SM,Burwell T,King AM,Barker PA,Singh L,Keaveney M,Morgenstern J,Gutiérrez-Ramos JC,Coyle AJ,Fraser CC
300-01A was used in Cell Culture to demonstrate the important role of IKKbeta in TNF-alpha-mediated mucus production in airway epithelium in vitro and in vivo.
Fri Oct 28 00:00:00 UTC 2005
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology
Toh K,Kukita T,Wu Z,Kukita A,Sandra F,Tang QY,Nomiyama H,Iijima T
Wed Sep 01 00:00:00 UTC 2004
IL-16 activates plasminogen-plasmin system and promotes human eosinophil migration into extracellular matrix via CCR3-chemokine-mediated signaling and by modulating CD4 eosinophil expression.
Journal of immunology (Baltimore, Md. : 1950)
Ferland C,Flamand N,Davoine F,Chakir J,Laviolette M
Fri Oct 01 00:00:00 UTC 2004
Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis.
The Journal of biological chemistry
Wickremasinghe MI,Thomas LH,O'Kane CM,Uddin J,Friedland JS
Fri Jun 25 00:00:00 UTC 2004
CD1-dependent dendritic cell instruction.
Nature immunology
Vincent MS,Leslie DS,Gumperz JE,Xiong X,Grant EP,Brenner MB
Sun Dec 01 00:00:00 UTC 2002
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
Cancer research
Azenshtein E,Luboshits G,Shina S,Neumark E,Shahbazian D,Weil M,Wigler N,Keydar I,Ben-Baruch A
Fri Feb 15 00:00:00 UTC 2002
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Maertzdorf J,Osterhaus AD,Verjans GM
Fri Nov 15 00:00:00 UTC 2002
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.
Cancer research
Hao C,Beguinot F,Condorelli G,Trencia A,Van Meir EG,Yong VW,Parney IF,Roa WH,Petruk KC
Thu Feb 01 00:00:00 UTC 2001
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 UTC 2000
The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.
American journal of physiology. Cell physiology
Tsai JC,Liu L,Guan J,Aird WC
Wed Nov 01 00:00:00 UTC 2000
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Blood
Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA
Sun Nov 15 00:00:00 UTC 1998
