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          • Proteins & Peptides ›
          • alpha-1 PDX Proteins

          Invitrogen

          Human alpha-1 PDX Recombinant Protein

          4 References

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          Cite Human alpha-1 PDX Recombinant Protein

          Product Details

          RP-070

          Applications
          Tested Dilution
          Publications

          Neutralization (Neu)

          -
          View 1 publication 1 publication

          Control (Ctrl)

          Assay-dependent
          -

          Inhibition Assays (IA)

          Cell studies, 8.0-20 µM
          -

          Miscellaneous PubMed (MISC)

          -
          View 3 publications 3 publications
          Product Specifications

          Species

          Human

          Published species

          Human

          Expression System

          E. coli

          Molecular weight

          46.7 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          >80%

          Activity

          For furin inhibition assays, cells should be treated with 8.0 - 20 µM human alpha-1 PDX recombinant protein for 1 hour. For in vitro assays, 0.1 - 2.0 µM human alpha-1 PDX recombinant protein should be used.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Concentration

          2.5 mg/mL

          Purification

          purified

          Storage buffer

          PBS, pH 7.2

          Contains

          no preservative

          Storage conditions

          4°C, do not freeze

          Shipping conditions

          Wet ice

          Product Specific Information

          RP-070 was obtained from E. coli transformed with the alpha1-PDX gene. RP-070 can be used in furin inhibition assays. For furin inhibition assays, cells should be treated with 8.0-20 µM alpha1-PDX for 1 hour (see above references). For in vitro assays, 0.1-2.0 µM alpha1-PDX should be used. Purity: >80% (most lots are 80-95%) NOTE: Freezing this product may result in damage of the protein. NOTE: Once rehydrated, this protein retains optimal reactivity for 2-4 days at 4 degrees C. Longer storage time can be achieved by storing in a serum rich medium. RP-070 can be used for protein biochemical, intracellular trafficking, and protein kinetic assays.

          Molecular weight is approximately 46.7 kDa.

          Target Information

          Alpha1-PDX is a potent and selective inhibitor of furin (Ki = 0.6 nM). Alpha1-PDX was engineered by the construction of a variant of alpha1-antitrypsin that contains a minimal furin consensus sequence, RXXR. Cellular expression of alpha1-PDX effectively blocks the furin-dependent processing of protein precursors. In addition, extracellular application of alpha1-PDX can also block the processing of furin substrates. Alpha1-PDX has been shown to inhibit the processing of biologically significant proteins including many viral envelope glycoproteins, bacterial toxins, receptors and growth factors.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          It has to be done as per old AB suggested Products section.
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