Product References
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
214-14 was used in In vitro experiments to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 UTC 2024
Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity.
Nature communications
Schapfl MA,LoMastro GM,Braun VZ,Hirai M,Levine MS,Kiermaier E,Labi V,Holland AJ,Villunger A
214-14 was used in Tissue/organ culture to show that early B cell progenitors frequently present extra centrioles, ensuing their high proliferative activity and related DNA damage.
Tue Oct 15 00:00:00 UTC 2024
Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation.
Cells
Purvis GSD,McNeill E,Wright B,Channon KM,Greaves DR
214-14 was used in In vitro experiments to investigate the origin and transcriptional reprogramming of monocytes using a model of acute inflammation, zymosan-induced peritonitis.
Sun May 26 00:00:00 UTC 2024
Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis.
Journal of nanobiotechnology
Zheng W,Li S,Shi Z,Su K,Ding Y,Zhang L,Tang Q,Han J,Zhao H,Wang F,Zhang H,Hong Z
214-14 was used in Cell Culture to develop a safe and effective neoantigen peptide delivery system (neoantigen-ferritin nanoparticles, neoantigen-FNs) that successfully achieved effective lymph node targeting and induced robust antitumor immune responses.
Sat Sep 14 00:00:00 UTC 2024
Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiao H,Du X,Tao Z,Jing N,Bao S,Gao WQ,Dong B,Fang YX
214-14 was used in In vitro experiments to indicate a reciprocal interaction between PCa cells and TAMs as a positive feedback-loop to repress ferroptosis in PCa, mediated by TAM-secreted taurine and tumor EV-delivered miR-181a-5p.
Mon Jan 01 00:00:00 UTC 2024
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines.
Nature nanotechnology
Han X,Alameh MG,Butowska K,Knox JJ,Lundgreen K,Ghattas M,Gong N,Xue L,Xu Y,Lavertu M,Bates P,Xu J,Nie G,Zhong Y,Weissman D,Mitchell MJ
214-14 was used in In vitro experiments to develop an Lipid nanoparticle component-an adjuvant lipidoid-that can enhance the adjuvanticity of mRNA-LNP vaccines.
Fri Sep 01 00:00:00 UTC 2023
Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression.
Journal of nanobiotechnology
Liu J,Xiang J,Jin C,Ye L,Wang L,Gao Y,Lv N,Zhang J,You F,Qiao H,Shi L
214-14 was used in In vitro experiments to isolate and purify the exosome-like particles from A. annua, which were characterized by nano-scaled and membrane-bound shape and hence termed artemisia-derived nanovesicles.
Mon Mar 06 00:00:00 UTC 2023
Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18.
Cell reports
Miyauchi S,Arimoto KI,Liu M,Zhang Y,Zhang DE
214-14 was used in Cell Culture to show that deletion of USP18 in myeloid cells suppresses tumor progression.
Tue Dec 26 00:00:00 UTC 2023
Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.
Theranostics
Chen L,Qin G,Liu Y,Li M,Li Y,Guo LZ,Du L,Zheng W,Wu PC,Chuang YH,Wang X,Wang TD,Ho JA,Liu TM
214-14 was used in In vitro experiments to successfully identifiy the differentiable features of prediabetic adipose tissues by employing the metabolic imaging of three endogenous fluorophores NAD(P)H, FAD, and lipofuscin-like pigments.
Mon Jul 17 00:00:00 UTC 2023
The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages.
Frontiers in immunology
Domokos A,Varga Z,Jambrovics K,Caballero-Sánchez N,Szabo E,Nagy G,Scholtz B,Halasz L,Varadi E,Bene KP,Mazlo A,Bacsi A,Jeney V,Szebeni GJ,Nagy L,Czimmerer Z
214-14 was used in Cell Culture to show that IL-4 can coordinately regulate the VEGFA-VEGFR1 (FLT1) axis via simultaneously inhibiting the proangiogenic Vegfa and inducing the antiangiogenic Flt1 expression in murine bone marrow-derived macrophages, which leads to the attenuated proangiogenic activity of alternatively polarized macrophages.
Wed May 24 00:00:00 UTC 2023
NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.
iScience
Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME
214-14 was used in In vitro experiments to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.
Fri Mar 17 00:00:00 UTC 2023
Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis.
Frontiers in cardiovascular medicine
van Os BW,Kusters PJH,den Toom M,Beckers L,van Tiel CM,Vos WG,de Jong E,Kieser A,van Roomen C,Binder CJ,Reiche ME,de Winther MP,Bosmans LA,Lutgens E
214-14 was used in In vitro experiments to investigate the role of TNIK-deficient B cells in atherosclerosis.
Tue May 23 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
214-14 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
214-14 was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 UTC 2023
Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
Scandinavian journal of immunology
Xu M,Ren J,Jia W,Wang S,Liu Y,Chen X,Shi J,Wang H
214-14 was used in In vitro experiments to reveal that Inpp4b is required in regulating B-1 cell numbers and B cell-mediated antibody production.
Sun Oct 01 00:00:00 UTC 2023
Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering.
Nature communications
Lee D,Dunn ZS,Guo W,Rosenthal CJ,Penn NE,Yu Y,Zhou K,Li Z,Ma F,Li M,Song TC,Cen X,Li YR,Zhou JJ,Pellegrini M,Wang P,Yang L
214-14 was used in In vitro experiments to engineer Vδ2 T cells with enhanced attributes (heightened cytotoxicity and potent antibody-dependent cell-mediated cytotoxicity functionality) by employing CD16 as a donor selection biomarker.
Wed Nov 08 00:00:00 UTC 2023
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis.
The Journal of experimental medicine
Rauschmeier R,Reinhardt A,Gustafsson C,Glaros V,Artemov AV,Dunst J,Taneja R,Adameyko I,Månsson R,Busslinger M,Kreslavsky T
Mon Feb 07 00:00:00 UTC 2022
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation.
Small (Weinheim an der Bergstrasse, Germany)
Kwak G,Cheng J,Kim H,Song S,Lee SJ,Yang Y,Jeong JH,Lee JE,Messersmith PB,Kim SH
Fri Apr 01 00:00:00 UTC 2022
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer.
EMBO molecular medicine
Zhou Q,Liang J,Yang T,Liu J,Li B,Li Y,Fan Z,Wang W,Chen W,Yuan S,Xu M,Xu Q,Luan Z,Xia Z,Zhou P,Huang Y,Chen L
214-14 was used in Cell Culture to conduct high-throughput screening to show that Carfilzomib potently drives M2 macrophages to express M1 cytokines, phagocytose tumor cells, and present antigens to T cells to suggest a potentially immediate application of combinational treatment with Carfilzomib and PD-1 inhibitors for patients with solid tumors.
Tue Jan 11 00:00:00 UTC 2022
Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment.
Oncogene
Fjæstad KY,Rømer AMA,Goitea V,Johansen AZ,Thorseth ML,Carretta M,Engelholm LH,Grøntved L,Junker N,Madsen DH
Tue Feb 01 00:00:00 UTC 2022
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Mucosal immunology
Spalinger MR,Crawford M,Bobardt SD,Li J,Sayoc-Becerra A,Santos AN,Shawki A,Chatterjee P,Nair MG,McCole DF
Sat Jan 01 00:00:00 UTC 2022
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Mucosal immunology
Spalinger MR,Crawford M,Bobardt SD,Li J,Sayoc-Becerra A,Santos AN,Shawki A,Chatterjee P,Nair MG,McCole DF
Sat Jan 01 00:00:00 UTC 2022
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Mucosal immunology
Nagatake T,Kishino S,Urano E,Murakami H,Kitamura N,Konishi K,Ohno H,Tiwari P,Morimoto S,Node E,Adachi J,Abe Y,Isoyama J,Sawane K,Honda T,Inoue A,Uwamizu A,Matsuzaka T,Miyamoto Y,Hirata SI,Saika A,Shibata Y,Hosomi K,Matsunaga A,Shimano H,Arita M,Aoki J,Oka M,Matsutani A,Tomonaga T,Kabashima K,Miyachi M,Yasutomi Y,Ogawa J,Kunisawa J
Tue Feb 01 00:00:00 UTC 2022
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation.
Mucosal immunology
Jaiswal AK,Yadav J,Makhija S,Mazumder S,Mitra AK,Suryawanshi A,Sandey M,Mishra A
Tue Feb 01 00:00:00 UTC 2022
Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.
American journal of physiology. Lung cellular and molecular physiology
Jaiswal AK,Yadav J,Makhija S,Sandey M,Suryawanshi A,Mitra AK,Mishra A
Sat Jan 01 00:00:00 UTC 2022
TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4+ T Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Kawahara E,Azuma M,Nagashima H,Omori K,Akiyama S,Fujimori Y,Oishi M,Shibui N,Kawaguchi K,Morita M,Okuyama Y,Ishii N,So T
Tue Feb 01 00:00:00 UTC 2022
Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells.
Mediators of inflammation
Li R,Hu X,Chen H,Zhao Y,Gao X,Yuan Y,Guo H,Huang H,Zou X,Qi H,Liu H,Shang Y
Thu Mar 31 00:00:00 UTC 2022
A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity.
Journal of immunology research
Zhang L,Du J,Song Q,Zhang C,Wu X
214-14 was used in Sample Preparation (FC/FACS) to study the synergistic antitumour effect of combining intralesional Rose Bengal (RB) with immature dendritic cells (DCs) (RB-iDCs) to reveal that the RB-iDC vaccine can synergistically destroy the primary tumour, inhibit distant metastasis, and prevent tumour relapse in a lung cancer mouse model, which provides important preclinical data for the development of a novel combinatorial immunotherapy.
Tue Mar 29 00:00:00 UTC 2022
Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.
Journal of clinical laboratory analysis
Xu W,Li S,Li M,Zhou H,Yang X
Sat Jan 01 00:00:00 UTC 2022
C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Nature communications
Park I,Goddard ME,Cole JE,Zanin N,Lyytikäinen LP,Lehtimäki T,Andreakos E,Feldmann M,Udalova I,Drozdov I,Monaco C
Tue Jan 11 00:00:00 UTC 2022
Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.
PLoS neglected tropical diseases
Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL
214-14 was used in Cell Culture to show that LdCen-/- containing neutrophils phagocytized by DC markedly influence the phenotype and antigen presenting capacity of DCs early on and thus play an immune-regulatory role in shaping vaccine induced host protective response.
Tue Feb 01 00:00:00 UTC 2022
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells.
Cells
Jatho A,Zieseniss A,Brechtel-Curth K,Guo J,Böker KO,Salinas G,Wenger RH,Katschinski DM
214-14 was used in Cell Culture to characterize the abundance of mesenchymal stem cell (MSC)-like cells after roxadustat treatment of mice.
Mon Feb 21 00:00:00 UTC 2022
An integrated toolbox to profile macrophage immunometabolism.
Cell reports methods
Verberk SGS,de Goede KE,Gorki FS,van Dierendonck XAMH,Argüello RJ,Van den Bossche J
214-14 was used in Cell Culture to propose an application of SCENITH technology for ex vivo metabolic profiling.
Mon Apr 25 00:00:00 UTC 2022
Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage.
Frontiers in pharmacology
He S,Gu X,Yang J,Xu F,Hu J,Wang W,Huang Y,Lou B,Ding T,Zhou L,Ye D,Yu K,Dong J
214-14 was used in Sample Preparation (Western Blotting) to study the role of sphingomyelin synthase 2 (SMS2) and the effect of the synthase 2 selective inhibitor YE2 in tumor-associated macrophage (TAMs) and the pancreatic tumor microenvironment.
Fri Nov 04 00:00:00 UTC 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
214-14 was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 UTC 2022
The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment.
Frontiers in pharmacology
Zhang Z,Chen WQ,Zhang SQ,Bai JX,Lau CL,Sze SC,Yung KK,Ko JK
214-14 was used in Cell Culture to study the anti-tumorigenic potential and mechanism of the cathelicidin family of peptide (LL-37) against pancreatic cancer and demonstrate LL-37 suppression of autophagy and tumor immune microenvironment reprogramming.
Tue Aug 09 00:00:00 UTC 2022
Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization.
iScience
Cheng Y,Yu Y,Zhuang Q,Wang L,Zhan B,Du S,Liu Y,Huang J,Hao J,Zhu X
214-14 was used in Cell Culture to investigate helminths in rheumatoid arthritis treatment.
Fri Mar 18 00:00:00 UTC 2022
C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
eLife
Jauch-Speer SL,Herrera-Rivero M,Ludwig N,Véras De Carvalho BC,Martens L,Wolf J,Imam Chasan A,Witten A,Markus B,Schieffer B,Vogl T,Rossaint J,Stoll M,Roth J,Fehler O
214-14 was used in Cell Culture to identify specific C/EBPδ-binding sites within S100a8 and S100a9 promoter regions, and demonstrated that C/EBPδ-dependent JMJD3-mediated demethylation of H3K27me3 is indispensable for their expression.
Wed May 11 00:00:00 UTC 2022
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
The Journal of general physiology
Wang L,Noyer L,Wang YH,Tao AY,Li W,Zhu J,Saavedra P,Hoda ST,Yang J,Feske S
214-14 was used in In vitro experiments to investigate the plasma membrane protein ORAI3 function in immune cells in mice.
Mon Oct 03 00:00:00 UTC 2022
PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models.
Cell communication and signaling : CCS
Zhan P,Cui Y,Cao Y,Bao X,Wu M,Yang Q,Yang J,Zheng H,Zou J,Xie T,Cai J,Yao Y,Wang X
214-14 was used in Cell Culture to describe the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the macrophage activation and choroidal neovascularization formation of wet Age-related macular degeneration.
Thu Oct 13 00:00:00 UTC 2022
Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages.
Frontiers in immunology
Gargani S,Lourou N,Arapatzi C,Tzanos D,Saridaki M,Dushku E,Chatzimike M,Sidiropoulos ND,Andreadou M,Ntafis V,Hatzis P,Kostourou V,Kontoyiannis DL
214-14 was used in Cell Culture to study the requirement of AUF1s in variable contexts of innate immune reactivity by restricting a debilitating AUF1 mutation to the mouse myeloid lineage and perform disease-oriented phenotypic analyses.
Fri Apr 08 00:00:00 UTC 2022
The ATG8 Family Proteins GABARAP and GABARAPL1 Target Antigen to Dendritic Cells to Prime CD4+ and CD8+ T Cells.
Cells
Fonderflick L,Baudu T,Adotévi O,Guittaut M,Adami P,Delage-Mourroux R
214-14 was used in Sample Preparation (FC/FACS) to show that B16-F10 cells that expressed the OVA-ATG8 fused proteins stimulated OVA-specific CD8+ T cells, but demonstrated no CD4+ T cell response.
Tue Sep 06 00:00:00 UTC 2022
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
Cell reports
Alam MM,Yang D,Li XQ,Liu J,Back TC,Trivett A,Karim B,Barbut D,Zasloff M,Oppenheim JJ
214-14 was used in In vitro experiments to show that αS is a critical mediator of inflammatory and immune responses.
Tue Jan 11 00:00:00 UTC 2022
Nanocarriers based on bacterial membrane materials for cancer vaccine delivery.
Nature protocols
Zhao X,Zhao R,Nie G
214-14 was used in Cell Culture to develop two different types of nanocarrier based on bacterial membrane materials, which employ genetically engineered outer-membrane vesicles (OMVs), or hybrid membrane vesicles containing bacterial cytoplasmic membrane, respectively.
Sat Oct 01 00:00:00 UTC 2022
Tanreqing Injection Attenuates Macrophage Activation and the Inflammatory Response via the lncRNA-SNHG1/HMGB1 Axis in Lipopolysaccharide-Induced Acute Lung Injury.
Frontiers in immunology
Hu C,Li J,Tan Y,Liu Y,Bai C,Gao J,Zhao S,Yao M,Lu X,Qiu L,Xing L
214-14 was used in In vitro experiments to investigate the pathogenesis and potential therapeutic targets of acute lung injury (ALI) and to define the target gene of Tanreqing (TRQ), which is a traditional Chinese medicine formula composed of five medicines, scutellaria baicalensis, bear bile powder, goat horn powder, honeysuckle and forsythia.
Tue May 17 00:00:00 UTC 2022
Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro.
Frontiers in pharmacology
Wang J,Wang Y,Huang R,Li W,Fan W,Hu X,Yang X,Han Q,Wang H,Liu G
214-14 was used in Cell Culture to provide a theoretical basis for further preclinical evaluation and lay a foundation for nano-gel compound treatment with Zizhu ointment.
Tue Sep 10 00:00:00 UTC 2024
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
214-14 was used in Cell Culture to investigate whether the activation of AhR can induce tolerogenic DCs (tolDCs) and the differentiation of regulatory T (Treg) cells, as well as ameliorate experimental colitis.
Sat Apr 23 00:00:00 UTC 2022
Evaluation of Glutaminolysis in T Cells.
Current protocols
Tajima M,Strober W
214-14 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.
Thu Sep 01 00:00:00 UTC 2022
Targeting Immunosuppressive Tumor-Associated Macrophages Using Innate T Cells for Enhanced Antitumor Reactivity.
Cancers
Li YR,Brown J,Yu Y,Lee D,Zhou K,Dunn ZS,Hon R,Wilson M,Kramer A,Zhu Y,Fang Y,Yang L
214-14 was used in Sample Preparation (FC/FACS) to evaluate the targeting efficacy CAR-engineered T cells on MAIT, iNKT, and γδT cells.
Wed Jun 01 00:00:00 UTC 2022
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.
Frontiers in immunology
Voss LF,Howarth AJ,Wittenborn TR,Hummelgaard S,Juul-Madsen K,Kastberg KS,Pedersen MK,Jensen L,Papanastasiou AD,Vorup-Jensen T,Weyer K,Degn SE
214-14 was used in Cell Culture to investigate the contribution of the extrafollicular pathway to autoimmune disease development.
Tue Jan 03 00:00:00 UTC 2023
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
ImmunoHorizons
Eddie AM,Chen KW,Schenkel LB,Swinger KK,Molina JR,Kunii K,Raybuck AL,Keilhack H,Gibson-Corley KN,Niepel M,Peebles RS,Boothby MR,Cho SH
214-14 was used in Sample Preparation (ELISA) to conclude that PARP14 catalytic activity can contribute to pathogenesis in allergic or atopic processes and propose that other biological endpoints dependent on ADP-ribosylation by PARP14 can be targeted using selective inhibition.
Mon Jul 11 00:00:00 UTC 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 UTC 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 UTC 2022
RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.
Cancers
Hunt BG,Jones A,Lester C,Davis JC,Benight NM,Waltz SE
214-14 was used in In vitro experiments to establish the functional significance of RON and HGFL co-overexpression on the activation of tumor cells and tumor-associated macrophages in breast cancer. TCGA and METABRIC gene expression and alteration data were used to query the relationships between MST1R and MST1 in breast cancer.
Thu May 19 00:00:00 UTC 2022
Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis.
Cell
Desai P,Janova H,White JP,Reynoso GV,Hickman HD,Baldridge MT,Urban JF,Stappenbeck TS,Thackray LB,Diamond MS
Thu Mar 04 00:00:00 UTC 2021
Follicular regulatory T cells produce neuritin to regulate B cells.
Cell
Gonzalez-Figueroa P,Roco JA,Papa I,Núñez Villacís L,Stanley M,Linterman MA,Dent A,Canete PF,Vinuesa CG
Thu Apr 01 00:00:00 UTC 2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
214-14 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 UTC 2021
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Immunity
Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D
Tue Aug 10 00:00:00 UTC 2021
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.
Immunity
Onodera T,Kita S,Adachi Y,Moriyama S,Sato A,Nomura T,Sakakibara S,Inoue T,Tadokoro T,Anraku Y,Yumoto K,Tian C,Fukuhara H,Sasaki M,Orba Y,Shiwa N,Iwata N,Nagata N,Suzuki T,Sasaki J,Sekizuka T,Tonouchi K,Sun L,Fukushi S,Satofuka H,Kazuki Y,Oshimura M,Kurosaki T,Kuroda M,Matsuura Y,Suzuki T,Sawa H,Hashiguchi T,Maenaka K,Takahashi Y
Tue Oct 12 00:00:00 UTC 2021
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.
Immunity
Onodera T,Kita S,Adachi Y,Moriyama S,Sato A,Nomura T,Sakakibara S,Inoue T,Tadokoro T,Anraku Y,Yumoto K,Tian C,Fukuhara H,Sasaki M,Orba Y,Shiwa N,Iwata N,Nagata N,Suzuki T,Sasaki J,Sekizuka T,Tonouchi K,Sun L,Fukushi S,Satofuka H,Kazuki Y,Oshimura M,Kurosaki T,Kuroda M,Matsuura Y,Suzuki T,Sawa H,Hashiguchi T,Maenaka K,Takahashi Y
Tue Oct 12 00:00:00 UTC 2021
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.
Immunity
Dikiy S,Li J,Bai L,Jiang M,Janke L,Zong X,Hao X,Hoyos B,Wang ZM,Xu B,Fan Y,Rudensky AY,Feng Y
Tue May 11 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Cell metabolism
Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA
Tue Dec 07 00:00:00 UTC 2021
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Cell metabolism
Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA
Tue Dec 07 00:00:00 UTC 2021
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Cellular & molecular immunology
Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R
Mon Feb 01 00:00:00 UTC 2021
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
The Journal of experimental medicine
Saveliev A,Bell SE,Turner M
Mon Mar 01 00:00:00 UTC 2021
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
The Journal of experimental medicine
Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F
Mon Jan 04 00:00:00 UTC 2021
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
The Journal of experimental medicine
Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y
Mon Dec 06 00:00:00 UTC 2021
MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
The Journal of experimental medicine
Wigton EJ,Mikami Y,McMonigle RJ,Castellanos CA,Wade-Vallance AK,Zhou SK,Kageyama R,Litterman A,Roy S,Kitamura D,Dykhuizen EC,Allen CDC,Hu H,O'Shea JJ,Ansel KM
Mon Nov 01 00:00:00 UTC 2021
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
The Journal of experimental medicine
Kiuchi M,Onodera A,Kokubo K,Ichikawa T,Morimoto Y,Kawakami E,Takayama N,Eto K,Koseki H,Hirahara K,Nakayama T
Mon Apr 05 00:00:00 UTC 2021
SLAM family receptors control pro-survival effectors in germinal center B cells to promote humoral immunity.
The Journal of experimental medicine
Zhong MC,Lu Y,Qian J,Zhu Y,Dong L,Zahn A,Di Noia JM,Karo-Atar D,King IL,Veillette A
Mon Mar 01 00:00:00 UTC 2021
SLAM family receptors control pro-survival effectors in germinal center B cells to promote humoral immunity.
The Journal of experimental medicine
Zhong MC,Lu Y,Qian J,Zhu Y,Dong L,Zahn A,Di Noia JM,Karo-Atar D,King IL,Veillette A
Mon Mar 01 00:00:00 UTC 2021
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
The Journal of experimental medicine
Fukuda K,Okamura K,Riding RL,Fan X,Afshari K,Haddadi NS,McCauley SM,Guney MH,Luban J,Funakoshi T,Yaguchi T,Kawakami Y,Khvorova A,Fitzgerald KA,Harris JE
Mon Sep 06 00:00:00 UTC 2021
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.
Autophagy
Yang G,Song W,Postoak JL,Chen J,Martinez J,Zhang J,Wu L,Van Kaer L
214-14 was used in Cell Culture to study the contribution of PIK3C3 to T cell metabolism and function to show that Pik3c3-deficient T cells exhibit impaired cellular metabolism, and that Pik3c3-deficient CD4+ T cells fail to differentiate into T helper 1 cells, changes which are associated with reduced levels of active mitochondria upon T cell activation.
Sat May 01 00:00:00 UTC 2021
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Zhang H,You X,Wang X,Cui L,Wang Z,Xu F,Li M,Yang Z,Liu J,Huang P,Kang Y,Wu J,Xia X
Tue Feb 09 00:00:00 UTC 2021
HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis.
Proceedings of the National Academy of Sciences of the United States of America
Senda N,Yanai H,Hibino S,Li L,Mizushima Y,Miyagaki T,Saeki M,Kishi Y,Hangai S,Nishio J,Sugaya M,Taniguchi T,Sato S
Tue Jan 05 00:00:00 UTC 2021
Physiological role of the 3'IgH CBEs super-anchor in antibody class switching.
Proceedings of the National Academy of Sciences of the United States of America
Zhang X,Yoon HS,Chapdelaine-Williams AM,Kyritsis N,Alt FW
Tue Jan 19 00:00:00 UTC 2021
Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity.
Cell death and differentiation
Chen J,Xu X,Li Y,Li F,Zhang J,Xu Q,Chen W,Wei Y,Wang X
214-14 was used in Cell Culture to study whether the Kdm6a pathway in adipose tissue macrophages (ATMs), which are involved in metabolic inflammation in obesity, regulate energy homeostasis.
Sat May 01 00:00:00 UTC 2021
STAT3/NF-κB signalling disruption in M2 tumour-associated macrophages is a major target of PLGA nanocarriers/PD-L1 antibody immunomodulatory therapy in breast cancer.
British journal of pharmacology
Cavalcante RS,Ishikawa U,Silva ES,Silva-Júnior AA,Araújo AA,Cruz LJ,Chan AB,de Araújo Júnior RF
Tue Jun 01 00:00:00 UTC 2021
Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation.
Gut microbes
Engevik MA,Herrmann B,Ruan W,Engevik AC,Engevik KA,Ihekweazu F,Shi Z,Luck B,Chang-Graham AL,Esparza M,Venable S,Horvath TD,Haidacher SJ,Hoch KM,Haag AM,Schady DA,Hyser JM,Spinler JK,Versalovic J
214-14 was used in Cell Culture to demonstrate positive modulation of the UPR and MUC2 production by B. dentium-secreted compounds.
Thu Nov 18 00:00:00 UTC 2021
Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses.
PLoS pathogens
Zhao M,Zhang Y,Yang X,Jin J,Shen Z,Feng X,Zou T,Deng L,Cheng D,Zhang X,Qin C,Niu C,Ye Z,Zhang X,He J,Hou C,Li G,Han G,Cheng Q,Wang Q,Wei L,Dong J,Zhang J
214-14 was used in Cell Culture to report that neddylation promotes RNA virus-induced type I IFN production, especially IFN-α.
Wed Sep 01 00:00:00 UTC 2021
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.
Acta pharmacologica Sinica
Deng Y,Hu JC,He SH,Lou B,Ding TB,Yang JT,Mo MG,Ye DY,Zhou L,Jiang XC,Yu K,Dong JB
214-14 was used in Western Blotting to reveal a novel and important role of SMS2 in the protumorigenic function and may offer a new strategy for macrophage-targeted anticancer therapy.
Fri Jan 01 00:00:00 UTC 2021
Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination.
Frontiers in cell and developmental biology
Sun X,Bai J,Xu J,Xi X,Gu M,Zhu C,Xue H,Chen C,Dong J
214-14 was used in Sample Preparation (FC/FACS) to show that CtIP and Mre11 both play critical role in mediating A-EJ CSR and DNA2 and the helicase/HRDC domain of BLM are required for A-EJ by mediating long S region DSB resection.
Tue Dec 21 00:00:00 UTC 2021
Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Petkevicius K,Bidault G,Virtue S,Jenkins B,van Dierendonck XAMH,Dugourd A,Saez-Rodriguez J,Stienstra R,Koulman A,Vidal-Puig A
Mon Feb 01 00:00:00 UTC 2021
Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
The FEBS journal
Hutter K,Rülicke T,Drach M,Andersen L,Villunger A,Herzog S
Mon Mar 01 00:00:00 UTC 2021
Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
The FEBS journal
Hutter K,Rülicke T,Drach M,Andersen L,Villunger A,Herzog S
Mon Mar 01 00:00:00 UTC 2021
TCR Affinity Controls the Dynamics but Not the Functional Specification of the Antimycobacterial CD4+ T Cell Response.
Journal of immunology (Baltimore, Md. : 1950)
Bhattacharyya ND,Counoupas C,Daniel L,Zhang G,Cook SJ,Cootes TA,Stifter SA,Bowen DG,Triccas JA,Bertolino P,Britton WJ,Feng CG
Tue Jun 15 00:00:00 UTC 2021
Atopic Neutrophils Prevent Postviral Airway Disease.
Journal of immunology (Baltimore, Md. : 1950)
Hussain SA,Rohlfing M,Resiliac J,Santoro J,Peeples ME,Garcin D,Grayson MH
Mon Nov 15 00:00:00 UTC 2021
Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ren J,Han X,Lohner H,Liang R,Liang S,Wang H
Thu Jul 01 00:00:00 UTC 2021
Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Hall SC,Smith DR,Dyavar SR,Wyatt TA,Samuelson DR,Bailey KL,Knoell DL
Wed Sep 01 00:00:00 UTC 2021
The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Xu N,Bai X,Liu Y,Yang Y,Tang B,Shi HN,Vallee I,Boireau P,Liu X,Liu M
Mon Mar 01 00:00:00 UTC 2021
A Monocyte-Orchestrated IFN-I-to-IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Guo P,Yang L,Zhang M,Zhang Y,Tong Y,Cao Y,Liu J
Thu Jul 15 00:00:00 UTC 2021
Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH
Mon Nov 15 00:00:00 UTC 2021
Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
Journal of immunology (Baltimore, Md. : 1950)
Finney J,Kelsoe G
Wed Sep 01 00:00:00 UTC 2021
The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis.
Journal of immunology (Baltimore, Md. : 1950)
Inoue T,Omori-Miyake M,Maruyama S,Okabe M,Kuwahara M,Honda H,Miura H,Yamashita M
Mon Nov 01 00:00:00 UTC 2021
GSK3 Restrains Germinal Center B Cells to Form Plasma Cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee J,Park H,Lim J,Jin HS,Park Y,Jung YJ,Ko HJ,Yoon SI,Lee GS,Kim PH,Choi SS,Xiao C,Kang SG
Mon Feb 01 00:00:00 UTC 2021
Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes.
Journal of immunology (Baltimore, Md. : 1950)
Afroj T,Mitsuhashi A,Ogino H,Saijo A,Otsuka K,Yoneda H,Tobiume M,Nguyen NT,Goto H,Koyama K,Sugimoto M,Kondoh O,Nokihara H,Nishioka Y
Mon Mar 15 00:00:00 UTC 2021
Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes.
Journal of immunology (Baltimore, Md. : 1950)
Afroj T,Mitsuhashi A,Ogino H,Saijo A,Otsuka K,Yoneda H,Tobiume M,Nguyen NT,Goto H,Koyama K,Sugimoto M,Kondoh O,Nokihara H,Nishioka Y
Mon Mar 15 00:00:00 UTC 2021
IL-4 Treatment Mitigates Experimental Cerebral Malaria by Reducing Parasitemia, Dampening Inflammation, and Lessening the Cytotoxicity of T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu X,Thylur RP,Dayanand KK,Punnath K,Norbury CC,Gowda DC
Fri Jan 01 00:00:00 UTC 2021
Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-β1/Smad3 pathway.
Journal of cellular and molecular medicine
Ying H,Fang M,Hang QQ,Chen Y,Qian X,Chen M
Wed Sep 01 00:00:00 UTC 2021
Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.
Journal of cellular and molecular medicine
Liu Y,Du M,Lin HY
Sun Aug 01 00:00:00 UTC 2021
Infusion of Kupffer Cells Expanded in Vitro Ameliorated Liver Fibrosis in a Murine Model of Liver Injury.
Cell transplantation
Li W,He F
214-14 was used in In vitro experiments to investigate the use of granulocyte-macrophage colony stimulating factor to produce Kupffer cells.
Wed Nov 17 00:00:00 UTC 2021
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.
Cell discovery
Lv J,Wang Z,Qu Y,Zhu H,Zhu Q,Tong W,Bao L,Lv Q,Cong J,Li D,Deng W,Yu P,Song J,Tong WM,Liu J,Liu Y,Qin C,Huang B
Tue Apr 13 00:00:00 UTC 2021
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
Mon Sep 13 00:00:00 UTC 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Fri Jun 25 00:00:00 UTC 2021
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Cell reports
Fremder M,Kim SW,Khamaysi A,Shimshilashvili L,Eini-Rider H,Park IS,Hadad U,Cheon JH,Ohana E
Tue Aug 10 00:00:00 UTC 2021
Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver.
Cells
Kang SG,Lee SE,Choi MJ,Chang JY,Kim JT,Zhang BY,Kang YE,Lee JH,Yi HS,Shong M
214-14 was used in In vivo experiments to demonstrate that the IL-4/IL-13-STAT6 axis regulates metabolic homeostasis through the induction of FGF21 in the liver.
Mon May 24 00:00:00 UTC 2021
Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
FEBS open bio
Cao X,Liu L,Zhang Y,Yang Y
Mon Feb 01 00:00:00 UTC 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Mon May 17 00:00:00 UTC 2021
Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production.
Frontiers in immunology
He J,Du Y,Li G,Xiao P,Sun X,Song W,Lai L,Xia M,Zhang J,Wang Q
214-14 was used in In vitro experiments to find that decreased expression of E3 ubiquitin ligase Fbxw7 in peripheral blood mononuclear cells (PBMCs) was significantly related to the severity of pulmonary fibrosis in Idiopathic pulmonary fibrosis patients.
Wed Feb 23 00:00:00 UTC 2022
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages.
FEBS open bio
Yao S,Zheng F,Yu Y,Zhan Y,Xu N,Luo G,Zheng L
Tue Jun 01 00:00:00 UTC 2021
Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation.
eLife
Russler-Germain EV,Yi J,Young S,Nutsch K,Wong HS,Ai TL,Chai JN,Durai V,Kaplan DH,Germain RN,Murphy KM,Hsieh CS
214-14 was used in In vitro experiments to suggest a model where DC-mediated effector T cell differentiation is 'dominant', necessitating that all DC subsets presenting antigen are permissive for pTreg cell induction to maintain gut tolerance.
Wed Feb 03 00:00:00 UTC 2021
Circulating mature dendritic cells homing to the thymus promote thymic epithelial cells involution via the Jagged1/Notch3 axis.
Cell death discovery
Wu H,Li X,Zhou C,Yu Q,Ge S,Pan Z,Zhao Y,Xia S,Zhou X,Liu X,Wang H,Shao Q
Mon Aug 30 00:00:00 UTC 2021
Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.
iScience
Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB
Fri Nov 19 00:00:00 UTC 2021
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription.
Cell reports
Sun L,Zhao X,Liu X,Zhong B,Tang H,Jin W,Clevers H,Wang H,Wang X,Dong C
Tue Jun 01 00:00:00 UTC 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 UTC 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 UTC 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Scientific reports
Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Tue Aug 24 00:00:00 UTC 2021
Characterization and Functional Analysis of Tumor-Derived Microparticles.
Current protocols
Ma J,Tang K,Zhang H,Wei K,Huang B
Tue Jun 01 00:00:00 UTC 2021
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.
Nature communications
Conde E,Bertrand R,Balbino B,Bonnefoy J,Stackowicz J,Caillot N,Colaone F,Hamdi S,Houmadi R,Loste A,Kamphuis JBJ,Huetz F,Guilleminault L,Gaudenzio N,Mougel A,Hardy D,Snouwaert JN,Koller BH,Serra V,Bruhns P,Grouard-Vogel G,Reber LL
Tue May 11 00:00:00 UTC 2021
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Nature communications
Muñoz-Rojas AR,Kelsey I,Pappalardo JL,Chen M,Miller-Jensen K
Tue Jan 12 00:00:00 UTC 2021
Sialomucin CD43 Plays a Deleterious Role in the Development of Experimental Heart Failure Induced by Pressure Overload by Modulating Cardiac Inflammation and Fibrosis.
Frontiers in physiology
Kaur K,Velázquez FE,Anastasiou M,Ngwenyama N,Smolgovsky S,Aronovitz M,Alcaide P
214-14 was used in Cell Culture to report that CD43-/- mice have improved survival to HF induced by transverse aortic constriction (TAC) and unveil a novel role for CD43 in adverse cardiac remodeling in pressure overload induced HF through modulation of cardiac T cell inflammation.
Wed Dec 14 00:00:00 UTC 2022
linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses.
Cell reports
Chen X,He Y,Zhu Y,Du J,Sun H
Tue Jan 05 00:00:00 UTC 2021
Talabostat Alleviates Obesity and Associated Metabolic Dysfunction via Suppression of Macrophage-Driven Adipose Inflammation.
Obesity (Silver Spring, Md.)
Wu Y,Shi T,Wang J,He R
214-14 was used in In vitro experiments to demonstrate that TB at a low dose could increase energy expenditure and control ATM-mediated adipose inflammation in obese mice, thereby alleviating obesity and its associated metabolic dysfunction.
Mon Feb 01 00:00:00 UTC 2021
CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter.
Cell reports
Prizant H,Patil N,Negatu S,Bala N,McGurk A,Leddon SA,Hughson A,McRae TD,Gao YR,Livingstone AM,Groom JR,Luster AD,Fowell DJ
Tue Aug 10 00:00:00 UTC 2021
Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells' maturation and function.
Open life sciences
Guo B,Peng Y,Gu Y,Zhong Y,Su C,Liu L,Chai D,Song T,Zhao N,Yan X,Xu T
214-14 was used in In vitro experiments to indicate that resveratrol (RES) participated in protecting against the pathological process of ALI by modulating the maturation and function of cDCs.
Fri Aug 16 00:00:00 UTC 2024
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Frontiers in immunology
Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP
214-14 was used in Cell Culture to investigate whether Cytochrome P450 26A1 (CYP26A1) regulates the polarization of uterine macrophages in early pregnancy.
Thu Feb 10 00:00:00 UTC 2022
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
Wed Jul 14 00:00:00 UTC 2021
Cell barrier function of resident peritoneal macrophages in post-operative adhesions.
Nature communications
Ito T,Shintani Y,Fields L,Shiraishi M,Podaru MN,Kainuma S,Yamashita K,Kobayashi K,Perretti M,Lewis-McDougall F,Suzuki K
Wed Apr 14 00:00:00 UTC 2021
Novel standardized method for extracellular flux analysis of oxidative and glycolytic metabolism in peripheral blood mononuclear cells.
Scientific reports
Janssen JJE,Lagerwaard B,Bunschoten A,Savelkoul HFJ,van Neerven RJJ,Keijer J,de Boer VCJ
Mon Jan 18 00:00:00 UTC 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
214-14 was used in Sample Preparation (Western Blotting) to study several compounds as inducers of PD-L1 degradation using a high-throughput drug screen to delineate a mechanism of PD-L1 degradation and cancer escape from immunity via EGFR-GSK3α-ARIH1 signaling and suggest GSK3α and ARIH1 might be potential drug targets to boost anti-tumor immunity and enhance immunotherapies.
Tue Apr 20 00:00:00 UTC 2021
ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation.
Nature communications
Wu Y,Zhang C,Liu X,He Z,Shan B,Zeng Q,Zhao Q,Zhu H,Liao H,Cen X,Xu X,Zhang M,Hou T,Wang Z,Yan H,Yang S,Sun Y,Chen Y,Wu R,Xie T,Chen W,Najafov A,Ying S,Xia H
214-14 was used in Sample Preparation (Western Blotting) to study several compounds as inducers of PD-L1 degradation using a high-throughput drug screen to delineate a mechanism of PD-L1 degradation and cancer escape from immunity via EGFR-GSK3α-ARIH1 signaling and suggest GSK3α and ARIH1 might be potential drug targets to boost anti-tumor immunity and enhance immunotherapies.
Tue Apr 20 00:00:00 UTC 2021
Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells.
Journal of experimental & clinical cancer research : CR
Li C,Shen Q,Zhang P,Wang T,Liu W,Li R,Ma X,Zeng X,Yin Y,Tao K
214-14 was used in Cell Culture to provide rational evidence that targeting MUS81 could elevate the expression of WEE1 by regulating its ubiquitination and could activate the innate immune response, thereby enhancing the anticancer efficacy of WEE1 inhibitor and immune checkpoint blockade combination therapy in gastric cancer cells.
Fri Oct 08 00:00:00 UTC 2021
Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models.
Scientific reports
Larsen SE,Reese VA,Pecor T,Berube BJ,Cooper SK,Brewer G,Ordway D,Henao-Tamayo M,Podell BK,Baldwin SL,Coler RN
Tue Apr 27 00:00:00 UTC 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
214-14 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 UTC 2021
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.
Nature communications
Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG
Fri Jan 08 00:00:00 UTC 2021
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Nature communications
Wang J,Wang J,Hong W,Zhang L,Song L,Shi Q,Shao Y,Hao G,Fang C,Qiu Y,Yang L,Yang Z,Wang J,Cao J,Yang B,He Q,Weng Q
Wed Oct 27 00:00:00 UTC 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
Wed May 12 00:00:00 UTC 2021
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Nature communications
Rodriguez-Garcia A,Lynn RC,Poussin M,Eiva MA,Shaw LC,O'Connor RS,Minutolo NG,Casado-Medrano V,Lopez G,Matsuyama T,Powell DJ
Tue Feb 09 00:00:00 UTC 2021
Dicer-independent snRNA/snoRNA-derived nuclear RNA 3 regulates tumor-associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription.
Cancer communications (London, England)
Shi Y,Shi Q,Shen Q,Zhang Q,Cao X
Mon Feb 01 00:00:00 UTC 2021
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Cell death & disease
Hu RD,Zhang W,Li L,Zuo ZQ,Ma M,Ma JF,Yin TT,Gao CY,Yang SH,Zhao ZB,Li ZJ,Qiao GB,Lian ZX,Qu K
Fri Oct 29 00:00:00 UTC 2021
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Nature communications
Yin H,Zhang X,Yang P,Zhang X,Peng Y,Li D,Yu Y,Wu Y,Wang Y,Zhang J,Ding X,Wang X,Yang A,Zhang R
Tue Mar 02 00:00:00 UTC 2021
Chronic stress physically spares but functionally impairs innate-like invariant T cells.
Cell reports
Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM
Tue Apr 13 00:00:00 UTC 2021
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages.
Nature communications
Wang Y,Tang B,Long L,Luo P,Xiang W,Li X,Wang H,Jiang Q,Tan X,Luo S,Li H,Wang Z,Chen Z,Leng Y,Jiang Z,Wang Y,Ma L,Wang R,Zeng C,Liu Z,Wang Y,Miao H,Shi C
Mon Jan 04 00:00:00 UTC 2021
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Scientific reports
Hasegawa H,Mizoguchi I,Orii N,Inoue S,Katahira Y,Yoneto T,Xu M,Miyazaki T,Yoshimoto T
Thu Mar 04 00:00:00 UTC 2021
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools.
The Journal of biological chemistry
Morgan PK,Huynh K,Pernes G,Miotto PM,Mellett NA,Giles C,Meikle PJ,Murphy AJ,Lancaster GI
Wed Dec 01 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching.
Cell reports
Bai W,Zhu G,Xu J,Chen P,Meng F,Xue H,Chen C,Dong J
Tue Sep 28 00:00:00 UTC 2021
The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9.
Cell death & disease
Tong Y,Yu Z,Chen Z,Zhang R,Ding X,Yang X,Niu X,Li M,Zhang L,Billiar TR,Pitt BR,Li Q
Mon Jan 11 00:00:00 UTC 2021
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice.
Scientific reports
Rodríguez MM,Onorato A,Cantero MJ,Domínguez L,Bayo J,Fiore E,García M,Atorrasagasti C,Canbay A,Malvicini M,Mazzolini GD
Thu Mar 18 00:00:00 UTC 2021
Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites.
Physiological reports
Engevik MA,Ruan W,Esparza M,Fultz R,Shi Z,Engevik KA,Engevik AC,Ihekweazu FD,Visuthranukul C,Venable S,Schady DA,Versalovic J
Fri Jan 01 00:00:00 UTC 2021
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Nature communications
Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY
Fri Jul 02 00:00:00 UTC 2021
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.
iScience
Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I
Fri Aug 20 00:00:00 UTC 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 UTC 2021
The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation.
Nature communications
Minns D,Smith KJ,Alessandrini V,Hardisty G,Melrose L,Jackson-Jones L,MacDonald AS,Davidson DJ,Gwyer Findlay E
Wed Feb 24 00:00:00 UTC 2021
Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.
Nature communications
Qin Y,Jia L,Liu H,Ma W,Ren X,Li H,Liu Y,Li H,Ma S,Liu M,Li P,Yan J,Zhang J,Guo Y,You H,Guo Y,Rahman NA,Wołczyński S,Kretowski A,Li D,Li X,Ren F,Li X
Thu Oct 21 00:00:00 UTC 2021
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
Cell reports
Szodoray P,Andersen TK,Heinzelbecker J,Imbery JF,Huszthy PC,Stanford SM,Bogen B,Landsverk OB,Bottini N,Tveita A,Munthe LA,Nakken B
Tue Aug 10 00:00:00 UTC 2021
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.
Cell metabolism
Ying W,Gao H,Dos Reis FCG,Bandyopadhyay G,Ofrecio JM,Luo Z,Ji Y,Jin Z,Ly C,Olefsky JM
214-14 was used in In vitro experiments to show that M2 polarized bone marrow-derived macrophages (BMDMs) secrete miRNA-containing exosomes (Exos), which improve glucose tolerance and insulin sensitivity when given to obese mice.
Tue Apr 06 00:00:00 UTC 2021
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Cell
Priem B,van Leent MMT,Teunissen AJP,Sofias AM,Mourits VP,Willemsen L,Klein ED,Oosterwijk RS,Meerwaldt AE,Munitz J,Prévot G,Vera Verschuur A,Nauta SA,van Leeuwen EM,Fisher EL,de Jong KAM,Zhao Y,Toner YC,Soultanidis G,Calcagno C,Bomans PHH,Friedrich H,Sommerdijk N,Reiner T,Duivenvoorden R,Zupančič E,Di Martino JS,Kluza E,Rashidian M,Ploegh HL,Dijkhuizen RM,Hak S,Pérez-Medina C,Bravo-Cordero JJ,de Winther MPJ,Joosten LAB,van Elsas A,Fayad ZA,Rialdi A,Torre D,Guccione E,Ochando J,Netea MG,Griffioen AW,Mulder WJM
Thu Oct 29 00:00:00 UTC 2020
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
Thu Aug 06 00:00:00 UTC 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
214-14 was used in In vitro experiments to find that the TME induces tumor cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4.
Thu Mar 19 00:00:00 UTC 2020
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.
Immunity
Remmerie A,Martens L,Thoné T,Castoldi A,Seurinck R,Pavie B,Roels J,Vanneste B,De Prijck S,Vanhockerhout M,Binte Abdul Latib M,Devisscher L,Hoorens A,Bonnardel J,Vandamme N,Kremer A,Borghgraef P,Van Vlierberghe H,Lippens S,Pearce E,Saeys Y,Scott CL
Tue Sep 15 00:00:00 UTC 2020
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 UTC 2020
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Immunity
Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B
Tue Sep 15 00:00:00 UTC 2020
High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships.
Immunity
Tortola L,Jacobs A,Pohlmeier L,Obermair FJ,Ampenberger F,Bodenmiller B,Kopf M
Tue Sep 15 00:00:00 UTC 2020
Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
Immunity
Delacher M,Imbusch CD,Hotz-Wagenblatt A,Mallm JP,Bauer K,Simon M,Riegel D,Rendeiro AF,Bittner S,Sanderink L,Pant A,Schmidleithner L,Braband KL,Echtenachter B,Fischer A,Giunchiglia V,Hoffmann P,Edinger M,Bock C,Rehli M,Brors B,Schmidl C,Feuerer M
Tue Feb 18 00:00:00 UTC 2020
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Cell stem cell
Fumagalli A,Oost KC,Kester L,Morgner J,Bornes L,Bruens L,Spaargaren L,Azkanaz M,Schelfhorst T,Beerling E,Heinz MC,Postrach D,Seinstra D,Sieuwerts AM,Martens JWM,van der Elst S,van Baalen M,Bhowmick D,Vrisekoop N,Ellenbroek SIJ,Suijkerbuijk SJE,Snippert HJ,van Rheenen J
214-14 was used in Tissue/organ culture to show that most colorectal cancer metastases are seeded by Lgr5- cells, which display intrinsic capacity to become CSCs in a niche-independent manner and can restore epithelial hierarchies in metastatic tumors.
Thu Apr 02 00:00:00 UTC 2020
Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors.
Cellular & molecular immunology
Wang L,Liu Z,Wang L,Wu Q,Li X,Xie D,Zhang H,Zhang Y,Gu L,Xue Y,Yue T,Liu G,Ji W,Wei H,Xu T,Bai L
Fri May 01 00:00:00 UTC 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 UTC 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 UTC 2020
Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress.
The Journal of clinical investigation
Tindemans I,van Schoonhoven A,KleinJan A,de Bruijn MJ,Lukkes M,van Nimwegen M,van den Branden A,Bergen IM,Corneth OB,van IJcken WF,Stadhouders R,Hendriks RW
Wed Jul 01 00:00:00 UTC 2020
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.
The Journal of clinical investigation
Faust HJ,Zhang H,Han J,Wolf MT,Jeon OH,Sadtler K,Peña AN,Chung L,Maestas DR,Tam AJ,Pardoll DM,Campisi J,Housseau F,Zhou D,Bingham CO,Elisseeff JH
Thu Oct 01 00:00:00 UTC 2020
IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.
The Journal of experimental medicine
Yang Z,Wu CM,Targ S,Allen CDC
Mon May 04 00:00:00 UTC 2020
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.
Nature chemical biology
Kapralov AA,Yang Q,Dar HH,Tyurina YY,Anthonymuthu TS,Kim R,St Croix CM,Mikulska-Ruminska K,Liu B,Shrivastava IH,Tyurin VA,Ting HC,Wu YL,Gao Y,Shurin GV,Artyukhova MA,Ponomareva LA,Timashev PS,Domingues RM,Stoyanovsky DA,Greenberger JS,Mallampalli RK,Bahar I,Gabrilovich DI,Bayır H,Kagan VE
214-14 was used in Cell Culture to discover that inducible nitric oxide synthase (iNOS)/NO-enrichment of activated M1 (but not alternatively activated M2) macrophages/microglia modulates susceptibility to ferroptosis.
Sun Mar 01 00:00:00 UTC 2020
FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
EMBO molecular medicine
Zaghdoudi S,Decaup E,Belhabib I,Samain R,Cassant-Sourdy S,Rochotte J,Brunel A,Schlaepfer D,Cros J,Neuzillet C,Strehaiano M,Alard A,Tomasini R,Rajeeve V,Perraud A,Mathonnet M,Pearce OM,Martineau Y,Pyronnet S,Bousquet C,Jean C
Fri Nov 06 00:00:00 UTC 2020
MNK2 governs the macrophage antiinflammatory phenotype.
Proceedings of the National Academy of Sciences of the United States of America
Bartish M,Tong D,Pan Y,Wallerius M,Liu H,Ristau J,de Souza Ferreira S,Wallmann T,van Hoef V,Masvidal L,Kerzel T,Joly AL,Goncalves C,Preston SEJ,Ebrahimian T,Seitz C,Bergh J,Pietras K,Lehoux S,Naldini L,Andersson J,Squadrito ML,Del Rincón SV,Larsson O,Rolny C
Tue Nov 03 00:00:00 UTC 2020
IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.
Proceedings of the National Academy of Sciences of the United States of America
Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F
Tue Feb 11 00:00:00 UTC 2020
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Proceedings of the National Academy of Sciences of the United States of America
Mikami N,Kawakami R,Chen KY,Sugimoto A,Ohkura N,Sakaguchi S
Tue Jun 02 00:00:00 UTC 2020
Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice.
Journal of cachexia, sarcopenia and muscle
Costamagna D,Duelen R,Penna F,Neumann D,Costelli P,Sampaolesi M
Mon Jun 01 00:00:00 UTC 2020
IL10 deficiency promotes alveolar enlargement and lymphoid dysmorphogenesis in the aged murine lung.
Aging cell
Malinina A,Dikeman D,Westbrook R,Moats M,Gidner S,Poonyagariyagorn H,Walston J,Neptune ER
Wed Apr 01 00:00:00 UTC 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 UTC 2020
Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production.
EMBO reports
Fernández-Messina L,Rodríguez-Galán A,de Yébenes VG,Gutiérrez-Vázquez C,Tenreiro S,Seabra MC,Ramiro AR,Sánchez-Madrid F
Fri Apr 03 00:00:00 UTC 2020
Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells.
Journal of cellular physiology
Shahir M,Mahmoud Hashemi S,Asadirad A,Varahram M,Kazempour-Dizaji M,Folkerts G,Garssen J,Adcock I,Mortaz E
Thu Oct 01 00:00:00 UTC 2020
RANKL-Targeted Combination Therapy with Osteoprotegerin Variant Devoid of TRAIL Binding Exerts Biphasic Effects on Skeletal Remodeling and Antitumor Immunity.
Molecular cancer therapeutics
Wang H,Ashton R,Hensel JA,Lee JH,Khattar V,Wang Y,Deshane JS,Ponnazhagan S
214-14 was used in Sample Preparation (FC/FACS) to establish the combine potential of TRAIL-binding-deficient-OPGY49R therapy with RANKL, against orthotopic and metastatic breast cancers, providing a viable alternate to existing therapeutic approaches.
Tue Dec 01 00:00:00 UTC 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 UTC 2020
LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li X,Zhang Y,Pei W,Zhang M,Yang H,Zhong M,Kong X,Xu Y,Zhu X,Chen T,Ye J,Lv K
Wed Apr 01 00:00:00 UTC 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
Wed Jan 01 00:00:00 UTC 2020
Depletion of miR-21 in dendritic cells aggravates renal ischemia-reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jia P,Pan T,Xu S,Fang Y,Song N,Guo M,Liang Y,Xu X,Ding X
Tue Sep 01 00:00:00 UTC 2020
Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fang W,Deng Z,Benadjaoud F,Yang D,Yang C,Shi GP
Wed Jul 01 00:00:00 UTC 2020
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D
Mon Jun 01 00:00:00 UTC 2020
Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Hollwedel FD,Maus R,Stolper J,Khan A,Stocker BL,Timmer MSM,Lu X,Pich A,Welte T,Yamasaki S,Maus UA
Tue Dec 15 00:00:00 UTC 2020
Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus.
Journal of immunology (Baltimore, Md. : 1950)
Zhu J,Hay AN,Potter AA,Richwine MW,Sproule T,LeRoith T,Wilson J,Hasham MG,Roopenian DC,Leeth CM
Sun Mar 01 00:00:00 UTC 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 UTC 2020
Single and Synergistic Effects of Type 2 Cytokines on Eosinophils and Asthma Hallmarks.
Journal of immunology (Baltimore, Md. : 1950)
Beckert H,Meyer-Martin H,Buhl R,Taube C,Reuter S
Sat Feb 01 00:00:00 UTC 2020
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Miki H,Han KH,Scott D,Croft M,Kang YJ
Wed Apr 01 00:00:00 UTC 2020
Tolerogenic Dendritic Cells Generated by BAFF Silencing Ameliorate Collagen-Induced Arthritis by Modulating the Th17/Regulatory T Cell Balance.
Journal of immunology (Baltimore, Md. : 1950)
Zhao Y,Sun X,Yang X,Zhang B,Li S,Han P,Zhang B,Wang X,Li S,Chang Y,Wei W
Sat Feb 01 00:00:00 UTC 2020
Tracing Self-Reactive B Cells in Normal Mice.
Journal of immunology (Baltimore, Md. : 1950)
Nojima T,Reynolds AE,Kitamura D,Kelsoe G,Kuraoka M
Wed Jul 01 00:00:00 UTC 2020
AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory.
Journal of immunology (Baltimore, Md. : 1950)
Brookens SK,Cho SH,Basso PJ,Boothby MR
Tue Dec 01 00:00:00 UTC 2020
P2Y6 Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W
Wed Jul 15 00:00:00 UTC 2020
Interleukin-38 alleviates cardiac remodelling after myocardial infarction.
Journal of cellular and molecular medicine
Wei Y,Lan Y,Zhong Y,Yu K,Xu W,Zhu R,Sun H,Ding Y,Wang Y,Zeng Q
Wed Jan 01 00:00:00 UTC 2020
Long non-coding RNA AK085865 ablation confers susceptibility to viral myocarditis by regulating macrophage polarization.
Journal of cellular and molecular medicine
Zhang Y,Li X,Kong X,Zhang M,Wang D,Liu Y,Lv K
Fri May 01 00:00:00 UTC 2020
Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Journal of cellular and molecular medicine
Zhao P,Zhou W,Zhang Y,Li J,Zhao Y,Pan L,Shen Z,Chen W,Hui J
Sat Feb 01 00:00:00 UTC 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
214-14 was used in Cell Culture to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus-stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 UTC 2020
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation.
Journal of neuroscience research
Liu J,Tang M,Harkin K,Du X,Luo C,Chen M,Xu H
214-14 was used in Cell Culture to suggest that photoreceptors express immune regulatory molecules and may have the potential to regulate immune activation in the outer retina/subretinal space under pathophysiological conditions.
Wed Jul 01 00:00:00 UTC 2020
Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis.
Nature communications
Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S,Herrmann M,Temchura V,Sarter K,Schett G,Zaiss MM
Fri Apr 24 00:00:00 UTC 2020
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
eLife
Alonso-Herranz L,Sahún-Español Á,Paredes A,Gonzalo P,Gkontra P,Núñez V,Clemente C,Cedenilla M,Villalba-Orero M,Inserte J,García-Dorado D,Arroyo AG,Ricote M
214-14 was used in Cell Culture to indicate the contribution of EndMT to cardiac fibrosis and adverse remodeling post-MI and identify Mφ MT1-MMP as a key regulator of this process.
Fri Oct 16 00:00:00 UTC 2020
Deficiency of Calcitonin Gene-Related Peptide Affects Macrophage Polarization in Osseointegration.
Frontiers in physiology
Yuan Y,Jiang Y,Wang B,Guo Y,Gong P,Xiang L
214-14 was used in Sample Preparation (FC/FACS) to study the effect of calcitonin gene-related peptide-α (CGRP) on macrophage polarization in titanium osseointegration.
Mon Sep 28 00:00:00 UTC 2020
Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis.
Cell death & disease
Xu F,Ma Y,Huang W,Gao J,Guo M,Li J,Kong L,Liang G,Du R,Xu Q,Wu X
Thu Aug 20 00:00:00 UTC 2020
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Nature communications
Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B
Tue Apr 14 00:00:00 UTC 2020
Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells.
Scientific reports
Roy S,Goel R,Aggarwal S,Asthana S,Yadav AK,Awasthi A
Fri Jul 03 00:00:00 UTC 2020
Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells.
Scientific reports
Roy S,Goel R,Aggarwal S,Asthana S,Yadav AK,Awasthi A
Fri Jul 03 00:00:00 UTC 2020
Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.
Nature communications
Bilska A,Kusio-Kobiałka M,Krawczyk PS,Gewartowska O,Tarkowski B,Kobyłecki K,Nowis D,Golab J,Gruchota J,Borsuk E,Dziembowski A,Mroczek S
Mon Apr 27 00:00:00 UTC 2020
Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Qin T,Ma S,Miao X,Tang Y,Huangfu D,Wang J,Jiang J,Xu N,Yin Y,Chen S,Liu X,Yin Y,Peng D,Gao L
Tue Sep 01 00:00:00 UTC 2020
Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming.
Cell death & disease
Yan K,Da TT,Bian ZH,He Y,Liu MC,Liu QZ,Long J,Li L,Gao CY,Yang SH,Zhao ZB,Lian ZX
Thu Sep 24 00:00:00 UTC 2020
Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance.
Cell reports
Apaydin DC,Jaramillo PAM,Corradi L,Cosco F,Rathjen FG,Kammertoens T,Filosa A,Sawamiphak S
214-14 was used in Cell Culture to show that exposure to brain-processed stress disrupts myocardial growth by reducing cardiomyocyte mitotic activity.
Tue Nov 17 00:00:00 UTC 2020
PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells.
FEBS open bio
Yashiro T,Takeuchi H,Kasakura K,Nishiyama C
Mon Jun 01 00:00:00 UTC 2020
PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 Stability and Promotes Prostaglandins E2-Mediated Inhibition of IgE Production in Asthma.
Frontiers in immunology
Wu J,Wang Y,Zhou Y,Wang Y,Sun X,Zhao Y,Guan Y,Zhang Y,Wang W
214-14 was used in In vitro experiments to study whether E-prostanoid 4 (EP4) receptor (encoded by Ptger4) has a unique or redundant role and demonstrate that mice with B cell-specific deletion of the EP4 receptor (Ptger4 fl/fl Mb1 cre+/-) show increased serum levels of IgE.
Mon Apr 05 00:00:00 UTC 2021
Triacylglycerol synthesis enhances macrophage inflammatory function.
Nature communications
Castoldi A,Monteiro LB,van Teijlingen Bakker N,Sanin DE,Rana N,Corrado M,Cameron AM,Hässler F,Matsushita M,Caputa G,Klein Geltink RI,Büscher J,Edwards-Hicks J,Pearce EL,Pearce EJ
Fri Aug 14 00:00:00 UTC 2020
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Redox biology
Xu F,Guo M,Huang W,Feng L,Zhu J,Luo K,Gao J,Zheng B,Kong LD,Pang T,Wu X,Xu Q
214-14 was used in In vitro experiments to associate Annexin A5 with the special effect on hepatic macrophage phenotype shift from M1 to M2.
Tue Sep 01 00:00:00 UTC 2020
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Scientific reports
Cai S,Choi JY,Borges TJ,Zhang H,Miao J,Ichimura T,Li X,Xu S,Chu P,Eskandari SK,Allos H,Alhaddad JB,Muhsin SA,Yatim K,Riella LV,Sage PT,Chandraker AK,Azzi JR
Fri Aug 28 00:00:00 UTC 2020
BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection.
Frontiers in immunology
Miao Y,Jiang M,Qi L,Yang D,Xiao W,Fang F
214-14 was used in Sample Preparation (Western Blotting) to investigate the role of BCAP and its interaction on dendritic cells.
Thu Mar 25 00:00:00 UTC 2021
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Scientific reports
Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK
Fri Jul 24 00:00:00 UTC 2020
Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection.
Frontiers in immunology
Genardi S,Visvabharathy L,Cao L,Morgun E,Cui Y,Qi C,Chen YH,Gapin L,Berdyshev E,Wang CR
214-14 was used in Cell Culture to study the role of unconventional T cells in Staphylococcus aureus (SA) infection.
Tue Jun 22 00:00:00 UTC 2021
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion.
Nature communications
Nahmad AD,Raviv Y,Horovitz-Fried M,Sofer I,Akriv T,Nataf D,Dotan I,Carmi Y,Burstein D,Wine Y,Benhar I,Barzel A
Tue Nov 17 00:00:00 UTC 2020
Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization.
Cell host & microbe
Panagi I,Jennings E,Zeng J,Günster RA,Stones CD,Mak H,Jin E,Stapels DAC,Subari NZ,Pham THM,Brewer SM,Ong SYQ,Monack DM,Helaine S,Thurston TLM
214-14 was used in In vitro experiments to demonstrate that SteE converts both the amino acid and substrate specificity of the host pleiotropic serine/threonine kinase GSK3.
Wed Jan 08 00:00:00 UTC 2020
Experimental Control of Macrophage Pro-Inflammatory Dynamics Using Predictive Models.
Frontiers in bioengineering and biotechnology
Weinstock LD,Forsmo JE,Wilkinson A,Ueda J,Wood LB
214-14 was used in Cell Culture to develop a model-predictive control framework to temporally regulate macrophage polarization.
Fri Mar 29 00:00:00 UTC 2024
A Comprehensive Experimental Guide to Studying Cross-Presentation in Dendritic Cells In Vitro.
Current protocols in immunology
Sadiq BA,Mantel I,Blander JM
214-14 was used in Cell Culture to describe methods to assess cross-presentation by DCs using the activation of primary CD8+ T cells as a readout.
Tue Dec 01 00:00:00 UTC 2020
Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
Aging
Castañeda-Zegarra S,Zhang Q,Alirezaylavasani A,Fernandez-Berrocal M,Yao R,Oksenych V
214-14 was used in Cell Culture to investigate mutations in non-homologous end joining proteins that result in severe combined immunodeficiency.
Mon Dec 07 00:00:00 UTC 2020
Preclinical Models for Studying the Impact of Macrophages on Cancer Cachexia.
Current protocols in pharmacology
Markov SD,Gonzalez D,Mehla K
214-14 was used in Sample Prep (FC/FACS) to describe in vitro and in vivo models used to study the role of macrophages in the induction of cachexia in pancreatic cancer.
Tue Dec 01 00:00:00 UTC 2020
Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response.
Nature communications
Yu X,Dai Y,Zhao Y,Qi S,Liu L,Lu L,Luo Q,Zhang Z
Fri Feb 28 00:00:00 UTC 2020
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.
Nature communications
Yin J,Kim SS,Choi E,Oh YT,Lin W,Kim TH,Sa JK,Hong JH,Park SH,Kwon HJ,Jin X,You Y,Kim JH,Kim H,Son J,Lee J,Nam DH,Choi KS,Shi B,Gwak HS,Yoo H,Iavarone A,Kim JH,Park JB
Fri Jun 12 00:00:00 UTC 2020
CD301 mediates fusion in IL-4-driven multinucleated giant cell formation.
Journal of cell science
Brooks PJ,Wang Y,Magalhaes MA,Glogauer M,McCulloch CA
214-14 was used in In vitro experiments to investigate the role of CD301 on multinucleated giant cells in mouse macrophages.
Wed Dec 23 00:00:00 UTC 2020
Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine.
Theranostics
Sun T,Kwong CHT,Gao C,Wei J,Yue L,Zhang J,Ye RD,Wang R
214-14 was used in In vitro experiments to investigate macrophage targeting in ulcerative colitis.
Fri May 28 00:00:00 UTC 2021
Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang J,Wang S,Ye T,Li F,Gao X,Wang Y,Ye P,Qing S,Wang C,Yue H,Wu J,Wei W,Ma G
Thu Oct 01 00:00:00 UTC 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
Tue Apr 14 00:00:00 UTC 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
Tue Apr 14 00:00:00 UTC 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
214-14 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 UTC 2020
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Nature communications
Baardman J,Verberk SGS,van der Velden S,Gijbels MJJ,van Roomen CPPA,Sluimer JC,Broos JY,Griffith GR,Prange KHM,van Weeghel M,Lakbir S,Molenaar D,Meinster E,Neele AE,Kooij G,de Vries HE,Lutgens E,Wellen KE,de Winther MPJ,Van den Bossche J
Tue Dec 08 00:00:00 UTC 2020
Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip.
eLife
Muri J,Thut H,Feng Q,Kopf M
214-14 was used in Cell Culture to show that in contrast to its critical role in T cells, the murine Trx1 system is dispensable for steady-state myeloid-cell hematopoiesis due to their capacity to tap the glutathione/glutaredoxin pathway for DNA biosynthesis.
Tue Feb 25 00:00:00 UTC 2020
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.
Journal of neuroinflammation
Li N,Stewart T,Sheng L,Shi M,Cilento EM,Wu Y,Hong JS,Zhang J
214-14 was used in In vitro experiments to examine the potential role of monomeric α-Syn in mediating microglia polarization to develop further insights into the connection between α-Syn, neuroinflammation, and Parkinson’s disease pathogenesis.
Thu Sep 17 00:00:00 UTC 2020
LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes.
Cell death & disease
Bai J,Zhang Y,Zheng X,Huang M,Cheng W,Shan H,Gao X,Zhang M,Sheng L,Dai J,Deng Y,Zhang H,Zhou X
Wed Sep 16 00:00:00 UTC 2020
Mouse intestinal tuft cells express advillin but not villin.
Scientific reports
Esmaeilniakooshkghazi A,George SP,Biswas R,Khurana S
Mon Jun 01 00:00:00 UTC 2020
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice.
Nature communications
Zuo B,Qi H,Lu Z,Chen L,Sun B,Yang R,Zhang Y,Liu Z,Gao X,You A,Wu L,Jing R,Zhou Q,Yin H
Tue Apr 14 00:00:00 UTC 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Thu Jul 11 00:00:00 UTC 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
Thu Oct 31 00:00:00 UTC 2019
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells.
Cell
Liu Z,Gu Y,Chakarov S,Bleriot C,Kwok I,Chen X,Shin A,Huang W,Dress RJ,Dutertre CA,Schlitzer A,Chen J,Ng LG,Wang H,Liu Z,Su B,Ginhoux F
Thu Sep 05 00:00:00 UTC 2019
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Cell research
Jacquelot N,Yamazaki T,Roberti MP,Duong CPM,Andrews MC,Verlingue L,Ferrere G,Becharef S,Vétizou M,Daillère R,Messaoudene M,Enot DP,Stoll G,Ugel S,Marigo I,Foong Ngiow S,Marabelle A,Prevost-Blondel A,Gaudreau PO,Gopalakrishnan V,Eggermont AM,Opolon P,Klein C,Madonna G,Ascierto PA,Sucker A,Schadendorf D,Smyth MJ,Soria JC,Kroemer G,Bronte V,Wargo J,Zitvogel L
Tue Oct 01 00:00:00 UTC 2019
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Immunity
Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM
Tue Mar 19 00:00:00 UTC 2019
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
Immunity
Dahlgren MW,Jones SW,Cautivo KM,Dubinin A,Ortiz-Carpena JF,Farhat S,Yu KS,Lee K,Wang C,Molofsky AV,Tward AD,Krummel MF,Peng T,Molofsky AB
Tue Mar 19 00:00:00 UTC 2019
The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.
Immunity
Xu W,Zhao X,Wang X,Feng H,Gou M,Jin W,Wang X,Liu X,Dong C
Tue Nov 19 00:00:00 UTC 2019
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.
Immunity
Ji L,Zhao X,Zhang B,Kang L,Song W,Zhao B,Xie W,Chen L,Hu X
Tue Aug 20 00:00:00 UTC 2019
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Immunity
Zhang F,Li R,Yang Y,Shi C,Shen Y,Lu C,Chen Y,Zhou W,Lin A,Yu L,Zhang W,Xue Z,Wang J,Cai Z
214-14 was used in Cell Culture to show that CD19+ extracellular vesicles from B cells through CD39 and CD73 vesicle-incorporated proteins hydrolyzed ATP from chemotherapy-treated tumor cells into adenosine, thus impairing CD8+ T cell responses.
Tue Mar 19 00:00:00 UTC 2019
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Immunity
Zhang F,Li R,Yang Y,Shi C,Shen Y,Lu C,Chen Y,Zhou W,Lin A,Yu L,Zhang W,Xue Z,Wang J,Cai Z
214-14 was used in Cell Culture to show that CD19+ extracellular vesicles from B cells through CD39 and CD73 vesicle-incorporated proteins hydrolyzed ATP from chemotherapy-treated tumor cells into adenosine, thus impairing CD8+ T cell responses.
Tue Mar 19 00:00:00 UTC 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
Tue May 21 00:00:00 UTC 2019
O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.
Immunity
Li X,Gong W,Wang H,Li T,Attri KS,Lewis RE,Kalil AC,Bhinderwala F,Powers R,Yin G,Herring LE,Asara JM,Lei YL,Yang X,Rodriguez DA,Yang M,Green DR,Singh PK,Wen H
Tue Mar 19 00:00:00 UTC 2019
Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.
Immunity
Gaylo-Moynihan A,Prizant H,Popović M,Fernandes NRJ,Anderson CS,Chiou KK,Bell H,Schrock DC,Schumacher J,Capece T,Walling BL,Topham DJ,Miller J,Smrcka AV,Kim M,Hughson A,Fowell DJ
Tue Aug 20 00:00:00 UTC 2019
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Immunity
Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG
Tue Aug 20 00:00:00 UTC 2019
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Immunity
Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG
Tue Aug 20 00:00:00 UTC 2019
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Immunity
Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB
Tue Aug 20 00:00:00 UTC 2019
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Cell metabolism
Puleston DJ,Buck MD,Klein Geltink RI,Kyle RL,Caputa G,O'Sullivan D,Cameron AM,Castoldi A,Musa Y,Kabat AM,Zhang Y,Flachsmann LJ,Field CS,Patterson AE,Scherer S,Alfei F,Baixauli F,Austin SK,Kelly B,Matsushita M,Curtis JD,Grzes KM,Villa M,Corrado M,Sanin DE,Qiu J,Pällman N,Paz K,Maccari ME,Blazar BR,Mittler G,Buescher JM,Zehn D,Rospert S,Pearce EJ,Balabanov S,Pearce EL
214-14 was used in Cell Culture to show that these results might have implications for therapeutically controlling macrophage activation by targeting the polyamine-eIF5A-hypusine axis.
Tue Aug 06 00:00:00 UTC 2019
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Cell metabolism
Halbrook CJ,Pontious C,Kovalenko I,Lapienyte L,Dreyer S,Lee HJ,Thurston G,Zhang Y,Lazarus J,Sajjakulnukit P,Hong HS,Kremer DM,Nelson BS,Kemp S,Zhang L,Chang D,Biankin A,Shi J,Frankel TL,Crawford HC,Morton JP,Pasca di Magliano M,Lyssiotis CA
214-14 was used in Cell Culture to characterise the role of macrophages in pancreatic ductal adenocarcinoma and possibilities for pancreatic cancer therapy.
Tue Jun 04 00:00:00 UTC 2019
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
The Journal of clinical investigation
Yamamoto A,Hester J,Macklin PS,Kawai K,Uchiyama M,Biggs D,Bishop T,Bull K,Cheng X,Cawthorne E,Coleman ML,Crockford TL,Davies B,Dow LE,Goldin R,Kranc K,Kudo H,Lawson H,McAuliffe J,Milward K,Scudamore CL,Soilleux E,Issa F,Ratcliffe PJ,Pugh CW
Tue Jun 04 00:00:00 UTC 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Tue Aug 13 00:00:00 UTC 2019
miR-142 controls metabolic reprogramming that regulates dendritic cell activation.
The Journal of clinical investigation
Sun Y,Oravecz-Wilson K,Bridges S,McEachin R,Wu J,Kim SH,Taylor A,Zajac C,Fujiwara H,Peltier DC,Saunders T,Reddy P
Mon Apr 08 00:00:00 UTC 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
214-14 was used in Cell Culture to show that reduced autophagy is a central molecular mechanism underlying immune senescence.
Thu Oct 03 00:00:00 UTC 2019
HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells.
The Journal of experimental medicine
Hartweger H,McGuire AT,Horning M,Taylor JJ,Dosenovic P,Yost D,Gazumyan A,Seaman MS,Stamatatos L,Jankovic M,Nussenzweig MC
214-14 was used in Cell Culture to investigate protective immunity against HIV-1.
Mon Jun 03 00:00:00 UTC 2019
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
The Journal of experimental medicine
von Gamm M,Schaub A,Jones AN,Wolf C,Behrens G,Lichti J,Essig K,Macht A,Pircher J,Ehrlich A,Davari K,Chauhan D,Busch B,Wurst W,Feederle R,Feuchtinger A,Tschöp MH,Friedel CC,Hauck SM,Sattler M,Geerlof A,Hornung V,Heissmeyer V,Schulz C,Heikenwalder M,Glasmacher E
Mon Jul 01 00:00:00 UTC 2019
CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
The Journal of experimental medicine
Rapp M,Wintergerst MWM,Kunz WG,Vetter VK,Knott MML,Lisowski D,Haubner S,Moder S,Thaler R,Eiber S,Meyer B,Röhrle N,Piseddu I,Grassmann S,Layritz P,Kühnemuth B,Stutte S,Bourquin C,von Andrian UH,Endres S,Anz D
Mon May 06 00:00:00 UTC 2019
BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses.
The EMBO journal
Dey A,Yang W,Gegonne A,Nishiyama A,Pan R,Yagi R,Grinberg A,Finkelman FD,Pfeifer K,Zhu J,Singer D,Zhu J,Ozato K
Mon Apr 01 00:00:00 UTC 2019
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Nepal S,Tiruppathi C,Tsukasaki Y,Farahany J,Mittal M,Rehman J,Prockop DJ,Malik AB
Tue Aug 13 00:00:00 UTC 2019
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Nepal S,Tiruppathi C,Tsukasaki Y,Farahany J,Mittal M,Rehman J,Prockop DJ,Malik AB
Tue Aug 13 00:00:00 UTC 2019
VISTA expressed in tumour cells regulates T cell function.
British journal of cancer
Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M
Tue Jan 01 00:00:00 UTC 2019
Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.
Mucosal immunology
Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y
Fri Mar 01 00:00:00 UTC 2019
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.
Mucosal immunology
Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J
Sun Sep 01 00:00:00 UTC 2019
A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor Is Highly Susceptible to Oral Infection with Clinical Isolates of Enterovirus 71.
Journal of virology
Yang CH,Liang CT,Jiang ST,Chen KH,Yang CC,Cheng ML,Ho HY
214-14 was used in Cell Culture to develop a transgenic mouse expressing mSCARB2/hSCARB2 receptor to model enterovirus 71 (EV71) pathogenesis, due to high resemblence to human neurological symptoms relating to EV71 infection, and for evaluating the efficacy of vaccines or other antiviral drugs.
Sat Jun 01 00:00:00 UTC 2019
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).
American journal of physiology. Lung cellular and molecular physiology
Cabrera S,Maciel M,Hernández-Barrientos D,Calyeca J,Gaxiola M,Selman M,Pardo A
214-14 was used in In vitro experiments to establish that MMP13 plays an antifibrotic role and its activity is crucial in lung repair and restoration of tissue integrity during fibrosis resolution.
Wed May 01 00:00:00 UTC 2019
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal
Schoeler K,Aufschnaiter A,Messner S,Derudder E,Herzog S,Villunger A,Rajewsky K,Labi V
Sun Sep 01 00:00:00 UTC 2019
Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5.
Journal of immunology (Baltimore, Md. : 1950)
Finney J,Yang G,Kuraoka M,Song S,Nojima T,Verkoczy L,Kitamura D,Haynes BF,Kelsoe G
Sun Dec 15 00:00:00 UTC 2019
Proteomic Profiling of Mouse Helper T Cell Differentiation.
Proteomics
van den Ham HJ,Binai NA,Zaaraoui-Boutahar F,Heck AJR,Andeweg AC
Mon Apr 01 00:00:00 UTC 2019
Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
Cell reports
Olson WJ,Jakic B,Labi V,Schoeler K,Kind M,Klepsch V,Baier G,Hermann-Kleiter N
214-14 was used in In vitro experiments to report that loss of the nuclear orphan receptor NR2F6 causes enhanced survival and accumulation of Tfh cells, GC B cells, and plasma cells following T cell-dependent immunization.
Tue Sep 10 00:00:00 UTC 2019
Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF-κB pathway.
Brain and behavior
Zhang L,Chen X,Liu Z,Han Q,Tang L,Tian Z,Ren Z,Rong C,Xu H
Tue Oct 01 00:00:00 UTC 2019
Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
Cell death & disease
Wang F,Sun F,Luo J,Yue T,Chen L,Zhou H,Zhang J,Yang C,Luo X,Zhou Q,Zhu H,Li J,Yang P,Xiong F,Yu Q,Zhang H,Zhang W,Xu A,Zhou Z,Lu Q,Eizirik DL,Zhang S,Wang CY
Tue Nov 26 00:00:00 UTC 2019
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Scientific reports
Minshawi F,White MRH,Muller W,Humphreys N,Jackson D,Campbell BJ,Adamson A,Papoutsopoulou S
Thu Jan 17 00:00:00 UTC 2019
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Nature communications
Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J
Fri Jul 05 00:00:00 UTC 2019
Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma.
Frontiers in genetics
Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M
214-14 was used in Cell Culture to explore the lncRNAs profile in the CD4+T cells from the mouse model of acute asthma.
Fri Apr 08 00:00:00 UTC 2022
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure.
Scientific reports
Verjans R,Derks WJA,Korn K,Sönnichsen B,van Leeuwen REW,Schroen B,van Bilsen M,Heymans S
Mon Apr 15 00:00:00 UTC 2019
Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D.
Nature communications
Jiang S,Lyu C,Zhao P,Li W,Kong W,Huang C,Genin GM,Du Y
Fri Aug 02 00:00:00 UTC 2019
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.
Nature communications
Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A
Wed Jul 24 00:00:00 UTC 2019
Immunometabolic modulation of retinal inflammation by CD36 ligand.
Scientific reports
Mellal K,Omri S,Mulumba M,Tahiri H,Fortin C,Dorion MF,Pham H,Garcia Ramos Y,Zhang J,Pundir S,Joyal JS,Bouchard JF,Sennlaub F,Febbraio M,Hardy P,Gravel SP,Marleau S,Lubell WD,Chemtob S,Ong H
Mon Sep 09 00:00:00 UTC 2019
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren.
Biomolecules
Castañeda-Zegarra S,Huse C,Røsand Ø,Sarno A,Xing M,Gago-Fuentes R,Zhang Q,Alirezaylavasani A,Werner J,Ji P,Liabakk NB,Wang W,Bjørås M,Oksenych V
214-14 was used in In vitro experiments to determine the physiological role of Mri in DNA repair and development.
Thu Nov 28 00:00:00 UTC 2019
Exosome-Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim H,Wang SY,Kwak G,Yang Y,Kwon IC,Kim SH
Wed Oct 16 00:00:00 UTC 2019
Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage.
Theranostics
Mei J,Zhou F,Qiao H,Li H,Tang T
214-14 was used in In vitro experiments to investigate the significance of sensory neuron neuropeptides and chemokine signals on inflammation-induced macrophages polarization during gouty arthritis.
Mon Sep 14 00:00:00 UTC 2020
Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis.
Scientific reports
Kiesewetter A,Cursiefen C,Eming SA,Hos D
Tue Jan 22 00:00:00 UTC 2019
Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.
The Journal of biological chemistry
Yin W,Song Y,Chang X
Fri Jan 04 00:00:00 UTC 2019
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID.
Nature communications
Rodríguez-Hernández G,Opitz FV,Delgado P,Walter C,Álvarez-Prado ÁF,González-Herrero I,Auer F,Fischer U,Janssen S,Bartenhagen C,Raboso-Gallego J,Casado-García A,Orfao A,Blanco O,Alonso-López D,Rivas JL,Tena-Dávila SG,Müschen M,Dugas M,Criado FJG,Cenador MBG,Vicente-Dueñas C,Hauer J,Ramiro AR,Sanchez-Garcia I,Borkhardt A
Thu Dec 05 00:00:00 UTC 2019
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
Cell reports
Sun D,Stopka-Farooqui U,Barry S,Aksoy E,Parsonage G,Vossenkämper A,Capasso M,Wan X,Norris S,Marshall JL,Clear A,Gribben J,MacDonald TT,Buckley CD,Korbonits M,Haworth O
214-14 was used in In vitro experiments to investigate if aryl hydrocarbon receptor interacting protein is a positive regulator of B cell lymphoma-6 expression.
Tue Apr 30 00:00:00 UTC 2019
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
Nature communications
Adachi Y,Tonouchi K,Nithichanon A,Kuraoka M,Watanabe A,Shinnakasu R,Asanuma H,Ainai A,Ohmi Y,Yamamoto T,Ishii KJ,Hasegawa H,Takeyama H,Lertmemongkolchai G,Kurosaki T,Ato M,Kelsoe G,Takahashi Y
Wed Aug 28 00:00:00 UTC 2019
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
The Journal of biological chemistry
Frossi B,Antoniali G,Yu K,Akhtar N,Kaplan MH,Kelley MR,Tell G,Pucillo CEM
Fri Mar 29 00:00:00 UTC 2019
Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.
JCI insight
Sun B,Chang HH,Salinger A,Tomita B,Bawadekar M,Holmes CL,Shelef MA,Weerapana E,Thompson PR,Ho IC
214-14 was used in In vitro experiments to highlight the potential and caveat of PAD2 as a therapeutic target of Th cell-mediated diseases.
Thu Nov 14 00:00:00 UTC 2019
Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson's disease model.
Scientific reports
Wang X,Saegusa H,Huntula S,Tanabe T
Mon Jun 24 00:00:00 UTC 2019
PRMT5 is essential for B cell development and germinal center dynamics.
Nature communications
Litzler LC,Zahn A,Meli AP,Hébert S,Patenaude AM,Methot SP,Sprumont A,Bois T,Kitamura D,Costantino S,King IL,Kleinman CL,Richard S,Di Noia JM
Thu Jan 03 00:00:00 UTC 2019
sgRNA Sequence Motifs Blocking Efficient CRISPR/Cas9-Mediated Gene Editing.
Cell reports
Graf R,Li X,Chu VT,Rajewsky K
214-14 was used in In vivo experiments to discover that two short sequence motifs at the 3' end of the targeting sequence are almost exclusively present in inefficient sgRNAs of published sgRNA-activity datasets and show that the presence of these motifs in sgRNAs per se results in a 10-fold reduction of gene knockout frequencies.
Tue Jan 29 00:00:00 UTC 2019
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
Cell reports
Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A
214-14 was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.
Tue Aug 20 00:00:00 UTC 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
Wed Mar 06 00:00:00 UTC 2019
Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.
Scientific reports
Knox T,Sahakian E,Banik D,Hadley M,Palmer E,Noonepalle S,Kim J,Powers J,Gracia-Hernandez M,Oliveira V,Cheng F,Chen J,Barinka C,Pinilla-Ibarz J,Lee NH,Kozikowski A,Villagra A
Tue Apr 16 00:00:00 UTC 2019
Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus.
Cell death & disease
Zheng X,Xiao ZX,Hu L,Fang X,Luo L,Chen L
Tue May 21 00:00:00 UTC 2019
Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.
Theranostics
Rodell CB,Ahmed MS,Garris CS,Pittet MJ,Weissleder R
214-14 was used in Cell Culture to describe the development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy.
Mon Sep 14 00:00:00 UTC 2020
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Nature
Ghezraoui H,Oliveira C,Becker JR,Bilham K,Moralli D,Anzilotti C,Fischer R,Deobagkar-Lele M,Sanchiz-Calvo M,Fueyo-Marcos E,Bonham S,Kessler BM,Rottenberg S,Cornall RJ,Green CM,Chapman JR
Wed Aug 01 00:00:00 UTC 2018
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
Cell
Schneider C,O'Leary CE,von Moltke J,Liang HE,Ang QY,Turnbaugh PJ,Radhakrishnan S,Pellizzon M,Ma A,Locksley RM
Thu Jul 12 00:00:00 UTC 2018
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Cell
Xiao G,Chan LN,Klemm L,Braas D,Chen Z,Geng H,Zhang QC,Aghajanirefah A,Cosgun KN,Sadras T,Lee J,Mirzapoiazova T,Salgia R,Ernst T,Hochhaus A,Jumaa H,Jiang X,Weinstock DM,Graeber TG,Müschen M
Thu Apr 05 00:00:00 UTC 2018
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell
Xia Y,Xie Y,Yu Z,Xiao H,Jiang G,Zhou X,Yang Y,Li X,Zhao M,Li L,Zheng M,Han S,Zong Z,Meng X,Deng H,Ye H,Fa Y,Wu H,Oldfield E,Hu X,Liu W,Shi Y,Zhang Y
Thu Nov 01 00:00:00 UTC 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
214-14 was used in In vivo experiments to study the mechanism by which B cells initially seed germinal centre reactions, and the role of follicular helper T cells in the regulation of this process.
Thu Jan 25 00:00:00 UTC 2018
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Nature methods
Squadrito ML,Cianciaruso C,Hansen SK,De Palma M
Thu Mar 01 00:00:00 UTC 2018
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
Mon Oct 01 00:00:00 UTC 2018
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
Mon Oct 01 00:00:00 UTC 2018
The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.
Immunity
Daniel B,Nagy G,Czimmerer Z,Horvath A,Hammers DW,Cuaranta-Monroy I,Poliska S,Tzerpos P,Kolostyak Z,Hays TT,Patsalos A,Houtman R,Sauer S,Francois-Deleuze J,Rastinejad F,Balint BL,Sweeney HL,Nagy L
Tue Oct 16 00:00:00 UTC 2018
Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis.
Immunity
Morimoto Y,Hirahara K,Kiuchi M,Wada T,Ichikawa T,Kanno T,Okano M,Kokubo K,Onodera A,Sakurai D,Okamoto Y,Nakayama T
Tue Jul 17 00:00:00 UTC 2018
The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.
Immunity
Czimmerer Z,Daniel B,Horvath A,Rückerl D,Nagy G,Kiss M,Peloquin M,Budai MM,Cuaranta-Monroy I,Simandi Z,Steiner L,Nagy B,Poliska S,Banko C,Bacso Z,Schulman IG,Sauer S,Deleuze JF,Allen JE,Benko S,Nagy L
Tue Jan 16 00:00:00 UTC 2018
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
Immunity
Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler G,Huang SC,Pearce EL,Pearce EJ
Tue Dec 18 00:00:00 UTC 2018
Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.
Immunity
Trompette A,Gollwitzer ES,Pattaroni C,Lopez-Mejia IC,Riva E,Pernot J,Ubags N,Fajas L,Nicod LP,Marsland BJ
Tue May 15 00:00:00 UTC 2018
Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging.
Immunity
Stewart I,Radtke D,Phillips B,McGowan SJ,Bannard O
Tue Sep 18 00:00:00 UTC 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 UTC 2018
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Cancer cell
Medler TR,Murugan D,Horton W,Kumar S,Cotechini T,Forsyth AM,Leyshock P,Leitenberger JJ,Kulesz-Martin M,Margolin AA,Werb Z,Coussens LM
Mon Oct 08 00:00:00 UTC 2018
Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression.
The Journal of clinical investigation
Hossain DMS,Javaid S,Cai M,Zhang C,Sawant A,Hinton M,Sathe M,Grein J,Blumenschein W,Pinheiro EM,Chackerian A
Thu Feb 01 00:00:00 UTC 2018
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Molecular cell
Hung PJ,Johnson B,Chen BR,Byrum AK,Bredemeyer AL,Yewdell WT,Johnson TE,Lee BJ,Deivasigamani S,Hindi I,Amatya P,Gross ML,Paull TT,Pisapia DJ,Chaudhuri J,Petrini JJH,Mosammaparast N,Amarasinghe GK,Zha S,Tyler JK,Sleckman BP
214-14 was used in Cell Culture to investigate if in G1-phase XRCC4 and the XRCC4-like factor-deficient lymphocytes, the modulator of retrovirus infection is required for cNHEJ-mediated repair of DNA double-strand breaks generated by RAG and the I-PpoI endonuclease.
Thu Jul 19 00:00:00 UTC 2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
Tue Jan 02 00:00:00 UTC 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
Mon Dec 03 00:00:00 UTC 2018
A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.
The Journal of experimental medicine
Le Gallou S,Zhou Z,Thai LH,Fritzen R,de Los Aires AV,Mégret J,Yu P,Kitamura D,Bille E,Tros F,Nassif X,Charbit A,Weller S,Weill JC,Reynaud CA
Mon Aug 06 00:00:00 UTC 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
Mon Sep 03 00:00:00 UTC 2018
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
The Journal of experimental medicine
Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y
Mon Nov 05 00:00:00 UTC 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 UTC 2018
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
The EMBO journal
Findlay S,Heath J,Luo VM,Malina A,Morin T,Coulombe Y,Djerir B,Li Z,Samiei A,Simo-Cheyou E,Karam M,Bagci H,Rahat D,Grapton D,Lavoie EG,Dove C,Khaled H,Kuasne H,Mann KK,Klein KO,Greenwood CM,Tabach Y,Park M,Côté JF,Masson JY,Maréchal A,Orthwein A
Fri Sep 14 00:00:00 UTC 2018
DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.
Proceedings of the National Academy of Sciences of the United States of America
Panchakshari RA,Zhang X,Kumar V,Du Z,Wei PC,Kao J,Dong J,Alt FW
Tue Jan 23 00:00:00 UTC 2018
CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.
Proceedings of the National Academy of Sciences of the United States of America
Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B
Tue Mar 27 00:00:00 UTC 2018
Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice.
Proceedings of the National Academy of Sciences of the United States of America
Raimondo TM,Mooney DJ
Tue Oct 16 00:00:00 UTC 2018
Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice.
Proceedings of the National Academy of Sciences of the United States of America
Raimondo TM,Mooney DJ
Tue Oct 16 00:00:00 UTC 2018
Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.
Proceedings of the National Academy of Sciences of the United States of America
Andreani V,Ramamoorthy S,Pandey A,Lupar E,Nutt SL,Lämmermann T,Grosschedl R
Tue Oct 09 00:00:00 UTC 2018
Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Paschalis EI,Lei F,Zhou C,Kapoulea V,Dana R,Chodosh J,Vavvas DG,Dohlman CH
Tue Nov 27 00:00:00 UTC 2018
Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Collmann FM,Pijnenburg R,Schneider G,Schäfer C,Folz-Donahue K,Kukat C,Hoehn M
214-14 was used in Sample Preparation (Western Blotting) to evaluate imaging promoter to monitor the activity of genes involved in microglia polarisation.
Sat Sep 01 00:00:00 UTC 2018
Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.
Journal of lipid research
Kriska T,Thomas MJ,Falck JR,Campbell WB
Sun Apr 01 00:00:00 UTC 2018
Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Iida M,Ikeda N,Moriyama S,Hamada M,Takahashi S,Kitamura H,Watanabe T,Hasegawa Y,Hase K,Fukuhara T,Sato H,Kobayashi EH,Suzuki T,Yamamoto M,Tanaka M,Asano K
Sun Jul 15 00:00:00 UTC 2018
GM-CSF Culture Revisited: Preparation of Bulk Populations of Highly Pure Dendritic Cells from Mouse Bone Marrow.
Journal of immunology (Baltimore, Md. : 1950)
Jin D,Sprent J
Thu Nov 15 00:00:00 UTC 2018
The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Tsau JS,Huang X,Lai CY,Hedrick SM
Thu Feb 15 00:00:00 UTC 2018
Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Dabitao D,Hedrich CM,Wang F,Vacharathit V,Bream JH
Thu Mar 15 00:00:00 UTC 2018
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.
Journal of immunology (Baltimore, Md. : 1950)
Woo JS,Srikanth S,Kim KD,Elsaesser H,Lu J,Pellegrini M,Brooks DG,Sun Z,Gwack Y
Wed Aug 15 00:00:00 UTC 2018
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Steinbuck MP,Arakcheeva K,Winandy S
Thu Feb 01 00:00:00 UTC 2018
TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Jayachandran N,Mejia EM,Sheikholeslami K,Sher AA,Hou S,Hatch GM,Marshall AJ
Sun Jul 15 00:00:00 UTC 2018
Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.
Journal of immunology (Baltimore, Md. : 1950)
Hu MD,Ethridge AD,Lipstein R,Kumar S,Wang Y,Jabri B,Turner JR,Edelblum KL
Sun Jul 15 00:00:00 UTC 2018
Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα.
Journal of immunology (Baltimore, Md. : 1950)
Guo H,Barberi T,Suresh R,Friedman AD
Sat Sep 15 00:00:00 UTC 2018
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.
Journal of immunology (Baltimore, Md. : 1950)
Dahal LN,Huang CY,Stopforth RJ,Mead A,Chan K,Bowater JX,Taylor MC,Narang P,Chan HTC,Kim JH,Vaughan AT,Forconi F,Beers SA
Wed Aug 15 00:00:00 UTC 2018
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
Journal of immunology (Baltimore, Md. : 1950)
Bian J,Liu R,Fan T,Liao L,Wang S,Geng W,Wang T,Shi W,Ruan Q
Sat Sep 01 00:00:00 UTC 2018
Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Gotru SK,Gil-Pulido J,Beyersdorf N,Diefenbach A,Becker IC,Vögtle T,Remer K,Chubanov V,Gudermann T,Hermanns HM,Nieswandt B,Kerkau T,Zernecke A,Braun A
Sun Apr 15 00:00:00 UTC 2018
TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Grunwell JR,Yeligar SM,Stephenson S,Ping XD,Gauthier TW,Fitzpatrick AM,Brown LAS
Thu Mar 15 00:00:00 UTC 2018
B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Chen YT,Su YC,Kung JT
Thu Nov 15 00:00:00 UTC 2018
Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Grau M,Valsesia S,Mafille J,Djebali S,Tomkowiak M,Mathieu AL,Laubreton D,de Bernard S,Jouve PE,Ventre E,Buffat L,Walzer T,Leverrier Y,Marvel J
Tue May 15 00:00:00 UTC 2018
Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Laky K,Padhan K,Petrovas C,Skinner J,Kabat J,Dorward DW,Brzostowski J,Long EO,Trinchieri G,Varma R
Thu Nov 15 00:00:00 UTC 2018
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Fuseini H,Yung JA,Cephus JY,Zhang J,Goleniewska K,Polosukhin VV,Peebles RS,Newcomb DC
Mon Oct 01 00:00:00 UTC 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 UTC 2018
Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5.
Journal of immunology (Baltimore, Md. : 1950)
Wang Y,Schafer CC,Hough KP,Tousif S,Duncan SR,Kearney JF,Ponnazhagan S,Hsu HC,Deshane JS
Sun Jul 01 00:00:00 UTC 2018
Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination.
Journal of immunology (Baltimore, Md. : 1950)
Kumar A,Priya A,Ahmed T,Grundström C,Negi N,Grundström T
Fri Jun 15 00:00:00 UTC 2018
IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Cui H,Banerjee S,Guo S,Xie N,Liu G
Tue May 01 00:00:00 UTC 2018
Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Alice AF,Kramer G,Bambina S,Baird JR,Bahjat KS,Gough MJ,Crittenden MR
Mon Jan 01 00:00:00 UTC 2018
IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Barik S,Cattin-Roy AN,Miller MM,Ukah TK,Zaghouani H
Thu Nov 15 00:00:00 UTC 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 UTC 2018
Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Kim H,Lv J,Zhao N,Ma X
Thu Feb 15 00:00:00 UTC 2018
Toxic adjuvants alter the function and phenotype of dendritic cells to initiate adaptive immune responses induced by oral Helicobacter pylori vaccines.
Helicobacter
Luo S,Liu W,Zeng Z,Ye F,Hu C,Xu N,Huang A,Xi T,Xing Y
Sat Dec 01 00:00:00 UTC 2018
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Cell stem cell
Sardina JL,Collombet S,Tian TV,Gómez A,Di Stefano B,Berenguer C,Brumbaugh J,Stadhouders R,Segura-Morales C,Gut M,Gut IG,Heath S,Aranda S,Di Croce L,Hochedlinger K,Thieffry D,Graf T
214-14 was used in Cell Culture to report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs).
Thu Nov 01 00:00:00 UTC 2018
Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease.
Cell death & disease
Du RH,Sun HB,Hu ZL,Lu M,Ding JH,Hu G
Wed Mar 14 00:00:00 UTC 2018
Antigen phagocytosis by B cells is required for a potent humoral response.
EMBO reports
Martínez-Riaño A,Bovolenta ER,Mendoza P,Oeste CL,Martín-Bermejo MJ,Bovolenta P,Turner M,Martínez-Martín N,Alarcón B
214-14 was used in In vitro experiments to suggest a new avenue for vaccination approaches by aiming to deliver 1-3 µm size antigen particles to follicular B cells.
Sat Sep 01 00:00:00 UTC 2018
Magnesium enhances the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation.
Scientific reports
Hu T,Xu H,Wang C,Qin H,An Z
Wed Feb 21 00:00:00 UTC 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
Nature communications
Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C
Thu Apr 12 00:00:00 UTC 2018
Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.
The Journal of biological chemistry
Ko CW,Counihan D,Wu J,Hatzoglou M,Puchowicz MA,Croniger CM
Fri Mar 02 00:00:00 UTC 2018
Reduced oxidative capacity in macrophages results in systemic insulin resistance.
Nature communications
Jung SB,Choi MJ,Ryu D,Yi HS,Lee SE,Chang JY,Chung HK,Kim YK,Kang SG,Lee JH,Kim KS,Kim HJ,Kim CS,Lee CH,Williams RW,Kim H,Lee HK,Auwerx J,Shong M
Thu Apr 19 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization.
Cell death & disease
Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J
Wed Feb 14 00:00:00 UTC 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 UTC 2018
A 21.6 kDa tegumental protein of Clonorchis sinensis induces a Th1/Th2 mixed immune response in mice.
Immunity, inflammation and disease
Chung E,Kim YJ,Lee MR,Cho SH,Ju JW
Sat Dec 01 00:00:00 UTC 2018
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.
Scientific reports
Lee EH,Itan M,Jang J,Gu HJ,Rozenberg P,Mingler MK,Wen T,Yoon J,Park SY,Roh JY,Choi CS,Park WJ,Munitz A,Jung Y
Mon Jul 02 00:00:00 UTC 2018
Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway.
Scientific reports
Nguyen TNY,Padungros P,Wongsrisupphakul P,Sa-Ard-Iam N,Mahanonda R,Matangkasombut O,Choo MK,Ritprajak P
Tue Nov 20 00:00:00 UTC 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
Mon Jul 16 00:00:00 UTC 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
Mon Jul 16 00:00:00 UTC 2018
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.
Nature communications
Kubota T,Inoue M,Kubota N,Takamoto I,Mineyama T,Iwayama K,Tokuyama K,Moroi M,Ueki K,Yamauchi T,Kadowaki T
Mon Nov 19 00:00:00 UTC 2018
C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.
Nature communications
Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM
Wed Jun 20 00:00:00 UTC 2018
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Nature communications
Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH
Fri Sep 14 00:00:00 UTC 2018
IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.
Cell death & disease
Reinhart R,Kaufmann T
Mon Jun 18 00:00:00 UTC 2018
A licensing step links AID to transcription elongation for mutagenesis in B cells.
Nature communications
Methot SP,Litzler LC,Subramani PG,Eranki AK,Fifield H,Patenaude AM,Gilmore JC,Santiago GE,Bagci H,Côté JF,Larijani M,Verdun RE,Di Noia JM
Wed Mar 28 00:00:00 UTC 2018
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction.
Nature communications
Xia H,Luo H,Shan C,Muruato AE,Nunes BTD,Medeiros DBA,Zou J,Xie X,Giraldo MI,Vasconcelos PFC,Weaver SC,Wang T,Rajsbaum R,Shi PY
Mon Jan 29 00:00:00 UTC 2018
Glycolysis promotes caspase-3 activation in lipid rafts in T cells.
Cell death & disease
Secinaro MA,Fortner KA,Dienz O,Logan A,Murphy MP,Anathy V,Boyson JE,Budd RC
Fri Jan 19 00:00:00 UTC 2018
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.
Nature communications
Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K
Tue Oct 30 00:00:00 UTC 2018
p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.
The Journal of biological chemistry
Zach F,Polzer F,Mueller A,Gessner A
Fri Jun 15 00:00:00 UTC 2018
Unique, Intersecting, and Overlapping Roles of C/EBP β and CREB in Cells of the Innate Immune System.
Scientific reports
Larabee JL,Hauck G,Ballard JD
Fri Nov 16 00:00:00 UTC 2018
Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density.
Nature communications
Yeh CH,Nojima T,Kuraoka M,Kelsoe G
Fri Mar 02 00:00:00 UTC 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 UTC 2018
Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors.
Cell death & disease
Yang Y,Ye YC,Chen Y,Zhao JL,Gao CC,Han H,Liu WC,Qin HY
Wed Jul 18 00:00:00 UTC 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Thu May 17 00:00:00 UTC 2018
Inflammation-induced iron transport and metabolism by brain microglia.
The Journal of biological chemistry
McCarthy RC,Sosa JC,Gardeck AM,Baez AS,Lee CH,Wessling-Resnick M
Fri May 18 00:00:00 UTC 2018
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.
Nature communications
Becker JR,Cuella-Martin R,Barazas M,Liu R,Oliveira C,Oliver AW,Bilham K,Holt AB,Blackford AN,Heierhorst J,Jonkers J,Rottenberg S,Chapman JR
Mon Dec 17 00:00:00 UTC 2018
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.
Cell
Oetjen LK,Mack MR,Feng J,Whelan TM,Niu H,Guo CJ,Chen S,Trier AM,Xu AZ,Tripathi SV,Luo J,Gao X,Yang L,Hamilton SL,Wang PL,Brestoff JR,Council ML,Brasington R,Schaffer A,Brombacher F,Hsieh CS,Gereau RW,Miller MJ,Chen ZF,Hu H,Davidson S,Liu Q,Kim BS
Thu Sep 21 00:00:00 UTC 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
214-14 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 UTC 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
214-14 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 UTC 2017
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.
Cell
Lim J,Giri PK,Kazadi D,Laffleur B,Zhang W,Grinstein V,Pefanis E,Brown LM,Ladewig E,Martin O,Chen Y,Rabadan R,Boyer F,Rothschild G,Cogné M,Pinaud E,Deng H,Basu U
Thu Apr 20 00:00:00 UTC 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
Tue Dec 19 00:00:00 UTC 2017
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Cancer cell
Poh AR,Love CG,Masson F,Preaudet A,Tsui C,Whitehead L,Monard S,Khakham Y,Burstroem L,Lessene G,Sieber O,Lowell C,Putoczki TL,O'Donoghue RJJ,Ernst M
Mon Apr 10 00:00:00 UTC 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
214-14 was used in In vitro experiments to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 UTC 2017
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Cell host & microbe
Wlodarska M,Luo C,Kolde R,d'Hennezel E,Annand JW,Heim CE,Krastel P,Schmitt EK,Omar AS,Creasey EA,Garner AL,Mohammadi S,O'Connell DJ,Abubucker S,Arthur TD,Franzosa EA,Huttenhower C,Murphy LO,Haiser HJ,Vlamakis H,Porter JA,Xavier RJ
214-14 was used in In vitro experiments to investigate the relationship between commensal intestinal microbes and the mucous layer.
Wed Jul 12 00:00:00 UTC 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
Mon Oct 02 00:00:00 UTC 2017
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
214-14 was used in In vitro experiments to study the role of CTCF in regulating cell-to-cell variation of expression.
Thu Sep 21 00:00:00 UTC 2017
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.
The Journal of experimental medicine
Pelly VS,Coomes SM,Kannan Y,Gialitakis M,Entwistle LJ,Perez-Lloret J,Czieso S,Okoye IS,Rückerl D,Allen JE,Brombacher F,Wilson MS
Mon Jun 05 00:00:00 UTC 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
Mon May 01 00:00:00 UTC 2017
Type I interferon is required for T helper (Th) 2 induction by dendritic cells.
The EMBO journal
Webb LM,Lundie RJ,Borger JG,Brown SL,Connor LM,Cartwright AN,Dougall AM,Wilbers RH,Cook PC,Jackson-Jones LH,Phythian-Adams AT,Johansson C,Davis DM,Dewals BG,Ronchese F,MacDonald AS
Tue Aug 15 00:00:00 UTC 2017
Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America
Nguyen HV,Dong J,Panchakshari RA,Kumar V,Alt FW,Bories JC
Tue Dec 05 00:00:00 UTC 2017
Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis.
Experimental & molecular medicine
Yu J,Choi S,Kim H,Lee N,Yun H,Kim S,Jeong ST,Rho J
Fri Nov 24 00:00:00 UTC 2017
Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling.
Experimental & molecular medicine
Kim JC,Jung YS,Lee HY,Park JS,Bae YS
Fri Aug 25 00:00:00 UTC 2017
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.
Oncogene
Castro BA,Flanigan P,Jahangiri A,Hoffman D,Chen W,Kuang R,De Lay M,Yagnik G,Wagner JR,Mascharak S,Sidorov M,Shrivastav S,Kohanbash G,Okada H,Aghi MK
214-14 was used in Cell Culture to study the mechanisms of resistance to anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab to show that bevacizumab resistance is driven by reduced migration inhibitory factor (MIF) at the tumor edge causing proliferative expansion of M2 macrophages, which in turn promotes tumor growth.
Thu Jun 29 00:00:00 UTC 2017
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene
Sochalska M,Schuler F,Weiss JG,Prchal-Murphy M,Sexl V,Villunger A
Sat Apr 01 00:00:00 UTC 2017
PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization.
Journal of immunology (Baltimore, Md. : 1950)
Sun HM,Chen XL,Chen XJ,Liu J,Ma L,Wu HY,Huang QH,Xi XD,Yin T,Zhu J,Chen Z,Chen SJ
Fri Sep 01 00:00:00 UTC 2017
Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ratiu JJ,Racine JJ,Hasham MG,Wang Q,Branca JA,Chapman HD,Zhu J,Donghia N,Philip V,Schott WH,Wasserfall C,Atkinson MA,Mills KD,Leeth CM,Serreze DV
Thu Jun 01 00:00:00 UTC 2017
Neuroendocrine Modulation of IL-27 in Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Roewe J,Higer M,Riehl DR,Gericke A,Radsak MP,Bosmann M
Sun Oct 01 00:00:00 UTC 2017
Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells.
Journal of immunology (Baltimore, Md. : 1950)
Onodera A,Kiuchi M,Kokubo K,Kato M,Ogino T,Horiuchi S,Kanai U,Hirahara K,Nakayama T
Tue Aug 01 00:00:00 UTC 2017
A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.
Journal of immunology (Baltimore, Md. : 1950)
Poston TB,Qu Y,Girardi J,O'Connell CM,Frazer LC,Russell AN,Wall M,Nagarajan UM,Darville T
Sun Oct 15 00:00:00 UTC 2017
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Clay GM,Valadares DG,Graff JW,Ulland TK,Davis RE,Scorza BM,Zhanbolat BS,Chen Y,Sutterwala FS,Wilson ME
Sun Oct 15 00:00:00 UTC 2017
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Ulrich BJ,Hummel SA,Khan I,Meuris B,Cherukuri Y,Dent AL,Janga SC,Kaplan MH
Thu Jun 01 00:00:00 UTC 2017
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Deng W,Yang J,Lin X,Shin J,Gao J,Zhong XP
Sun Jan 01 00:00:00 UTC 2017
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Scientific reports
Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K
Mon Oct 16 00:00:00 UTC 2017
Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells.
Scientific reports
Wu H,Weidinger C,Schmidt F,Keye J,Friedrich M,Yerinde C,Willimsky G,Qin Z,Siegmund B,Glauben R
Tue Aug 08 00:00:00 UTC 2017
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.
Nature communications
Dubey LK,Karempudi P,Luther SA,Ludewig B,Harris NL
Mon Aug 28 00:00:00 UTC 2017
Physiologically activated mammary fibroblasts promote postpartum mammary cancer.
JCI insight
Guo Q,Minnier J,Burchard J,Chiotti K,Spellman P,Schedin P
214-14 was used in Sample Preparation (FC/FACS) to assess fibroblasts isolated from the involuting mammary gland of nulliparous and postweaning mice for activation phenotype and protumourigenic function.
Thu Mar 23 00:00:00 UTC 2017
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes.
Scientific reports
Bai L,Liu X,Zheng Q,Kong M,Zhang X,Hu R,Lou J,Ren F,Chen Y,Zheng S,Liu S,Han YP,Duan Z,Pandol SJ
Tue Sep 05 00:00:00 UTC 2017
The AP-1 transcription factor JunB is required for Th17 cell differentiation.
Scientific reports
Yamazaki S,Tanaka Y,Araki H,Kohda A,Sanematsu F,Arasaki T,Duan X,Miura F,Katagiri T,Shindo R,Nakano H,Ito T,Fukui Y,Endo S,Sumimoto H
Tue Dec 12 00:00:00 UTC 2017
Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.
The Journal of biological chemistry
Guo X,Li T,Xu Y,Xu X,Zhu Z,Zhang Y,Xu J,Xu K,Cheng H,Zhang X,Ke Y
Fri Aug 25 00:00:00 UTC 2017
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Scientific reports
Lee YS,Lee MH,Kim HJ,Won HR,Kim CH
Tue Nov 14 00:00:00 UTC 2017
MafB is a critical regulator of complement component C1q.
Nature communications
Tran MTN,Hamada M,Jeon H,Shiraishi R,Asano K,Hattori M,Nakamura M,Imamura Y,Tsunakawa Y,Fujii R,Usui T,Kulathunga K,Andrea CS,Koshida R,Kamei R,Matsunaga Y,Kobayashi M,Oishi H,Kudo T,Takahashi S
214-14 was used in Cell Culture to study the function of MafB in the context of regulation of C1q.
Wed Nov 22 00:00:00 UTC 2017
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.
Nature communications
Nawaz A,Aminuddin A,Kado T,Takikawa A,Yamamoto S,Tsuneyama K,Igarashi Y,Ikutani M,Nishida Y,Nagai Y,Takatsu K,Imura J,Sasahara M,Okazaki Y,Ueki K,Okamura T,Tokuyama K,Ando A,Matsumoto M,Mori H,Nakagawa T,Kobayashi N,Saeki K,Usui I,Fujisaka S,Tobe K
Fri Aug 18 00:00:00 UTC 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Mon Feb 06 00:00:00 UTC 2017
Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.
Nature communications
Díaz-Muñoz MD,Kiselev VY,Le Novère N,Curk T,Ule J,Turner M
Wed Sep 13 00:00:00 UTC 2017
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Nature communications
Song Y,Lai L,Chong Z,He J,Zhang Y,Xue Y,Xie Y,Chen S,Dong P,Chen L,Chen Z,Dai F,Wan X,Xiao P,Cao X,Liu Y,Wang Q
214-14 was used in Cell Culture to identify FBXW7 as an important interacting partner for RIG-I.
Mon Mar 13 00:00:00 UTC 2017
IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.
Scientific reports
Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K
214-14 was used in In vivo experiments to show the proof-of-concept of efficacy of IL-4 treatment for acute myocardial infarction, encouraging its further development.
Mon Jul 31 00:00:00 UTC 2017
A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages.
Scientific reports
Boorsma CE,van der Veen TA,Putri KSS,de Almeida A,Draijer C,Mauad T,Fejer G,Brandsma CA,van den Berge M,Bossé Y,Sin D,Hao K,Reithmeier A,Andersson G,Olinga P,Timens W,Casini A,Melgert BN
Tue Oct 03 00:00:00 UTC 2017
Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro.
ACS chemical neuroscience
Ziemba AM,Gottipati MK,Totsingan F,Hanes CM,Gross RA,Lennartz MR,Gilbert RJ
214-14 was used in Cell Culture to study the response of peritoneal macrophages (PMACs) and spinal cord astrocytes to soluble sophorolipid butyl ester diacetate (SLBEDA) in vitro.
Wed Apr 19 00:00:00 UTC 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
Fri Feb 03 00:00:00 UTC 2017
Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy.
Scientific reports
Riuzzi F,Beccafico S,Sagheddu R,Chiappalupi S,Giambanco I,Bereshchenko O,Riccardi C,Sorci G,Donato R
Mon Oct 02 00:00:00 UTC 2017
A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE.
Scientific reports
Wei HJ,Pareek TK,Liu Q,Letterio JJ
Tue Aug 29 00:00:00 UTC 2017
IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.
Scientific reports
Mitchell RE,Hassan M,Burton BR,Britton G,Hill EV,Verhagen J,Wraith DC
Tue Sep 12 00:00:00 UTC 2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
Wed Mar 15 00:00:00 UTC 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Wed Oct 18 00:00:00 UTC 2017
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.
The Journal of biological chemistry
Van de Velde LA,Subramanian C,Smith AM,Barron L,Qualls JE,Neale G,Alfonso-Pecchio A,Jackowski S,Rock CO,Wynn TA,Murray PJ
Fri Jan 06 00:00:00 UTC 2017
CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal.
The Journal of biological chemistry
Enyindah-Asonye G,Li Y,Xin W,Singer NG,Gupta N,Fung J,Lin F
Fri Jan 13 00:00:00 UTC 2017
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
Thu Aug 24 00:00:00 UTC 2017
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.
Nature
Gerbe F,Sidot E,Smyth DJ,Ohmoto M,Matsumoto I,Dardalhon V,Cesses P,Garnier L,Pouzolles M,Brulin B,Bruschi M,Harcus Y,Zimmermann VS,Taylor N,Maizels RM,Jay P
214-14 was used in In vivo experiments to study the mechanisms underlying the initiation of type 2 host responses to helminths such as Nippostrongylus brasiliensis to reveal a novel function of intestinal epithelial tuft cells and demonstrate a cellular relay required for initiating mucosal type 2 immunity to helminth infection.
Thu Jan 14 00:00:00 UTC 2016
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.
Cell research
Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y
Tue Nov 01 00:00:00 UTC 2016
The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
Cell research
Yang Y,Wang SY,Huang ZF,Zou HM,Yan BR,Luo WW,Wang YY
Tue Mar 01 00:00:00 UTC 2016
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.
Immunity
Kuraoka M,Schmidt AG,Nojima T,Feng F,Watanabe A,Kitamura D,Harrison SC,Kepler TB,Kelsoe G
Tue Mar 15 00:00:00 UTC 2016
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Immunity
Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C
Tue Jun 21 00:00:00 UTC 2016
Donor dendritic cell-derived exosomes promote allograft-targeting immune response.
The Journal of clinical investigation
Liu Q,Rojas-Canales DM,Divito SJ,Shufesky WJ,Stolz DB,Erdos G,Sullivan ML,Gibson GA,Watkins SC,Larregina AT,Morelli AE
Mon Aug 01 00:00:00 UTC 2016
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
The Journal of clinical investigation
Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K
Wed Jun 01 00:00:00 UTC 2016
miR-23∼27∼24 clusters control effector T cell differentiation and function.
The Journal of experimental medicine
Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF
Mon Feb 08 00:00:00 UTC 2016
Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.
The Journal of experimental medicine
Hayakawa K,Formica AM,Brill-Dashoff J,Shinton SA,Ichikawa D,Zhou Y,Morse HC,Hardy RR
Mon Dec 12 00:00:00 UTC 2016
PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.
The Journal of experimental medicine
Kong D,Shen Y,Liu G,Zuo S,Ji Y,Lu A,Nakamura M,Lazarus M,Stratakis CA,Breyer RM,Yu Y
Mon Sep 19 00:00:00 UTC 2016
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
The Journal of experimental medicine
Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G
Mon Oct 17 00:00:00 UTC 2016
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
The Journal of experimental medicine
Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C
Mon Aug 22 00:00:00 UTC 2016
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
The Journal of experimental medicine
Wan X,Thomas JW,Unanue ER
Mon May 30 00:00:00 UTC 2016
Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.
The Journal of experimental medicine
Thomas-Claudepierre AS,Robert I,Rocha PP,Raviram R,Schiavo E,Heyer V,Bonneau R,Luo VM,Reddy JK,Borggrefe T,Skok JA,Reina-San-Martin B
Mon Mar 07 00:00:00 UTC 2016
UNG protects B cells from AID-induced telomere loss.
The Journal of experimental medicine
Cortizas EM,Zahn A,Safavi S,Reed JA,Vega F,Di Noia JM,Verdun RE
Mon Oct 17 00:00:00 UTC 2016
IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.
The Journal of experimental medicine
Domeier PP,Chodisetti SB,Soni C,Schell SL,Elias MJ,Wong EB,Cooper TK,Kitamura D,Rahman ZS
Mon May 02 00:00:00 UTC 2016
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.
The Journal of experimental medicine
Kretzer NM,Theisen DJ,Tussiwand R,Briseño CG,Grajales-Reyes GE,Wu X,Durai V,Albring J,Bagadia P,Murphy TL,Murphy KM
Mon Dec 12 00:00:00 UTC 2016
Scavenging nucleic acid debris to combat autoimmunity and infectious disease.
Proceedings of the National Academy of Sciences of the United States of America
Holl EK,Shumansky KL,Borst LB,Burnette AD,Sample CJ,Ramsburg EA,Sullenger BA
Tue Aug 30 00:00:00 UTC 2016
ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Lin EC,Amantea CM,Nomanbhoy TK,Weissig H,Ishiyama J,Hu Y,Sidique S,Li B,Kozarich JW,Rosenblum JS
Tue Oct 18 00:00:00 UTC 2016
miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα.
Molecular therapy. Nucleic acids
Bi J,Zeng X,Zhao L,Wei Q,Yu L,Wang X,Yu Z,Cao Y,Shan F,Wei M
Tue Sep 27 00:00:00 UTC 2016
miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα.
Molecular therapy. Nucleic acids
Bi J,Zeng X,Zhao L,Wei Q,Yu L,Wang X,Yu Z,Cao Y,Shan F,Wei M
Tue Sep 27 00:00:00 UTC 2016
IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.
European journal of immunology
Jackson-Jones LH,Rückerl D,Svedberg F,Duncan S,Maizels RM,Sutherland TE,Jenkins SJ,McSorley HJ,Bénézech C,MacDonald AS,Allen JE
Sat Oct 01 00:00:00 UTC 2016
Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model.
Cancer science
Takahara T,Matsuo K,Seto M,Nakamura S,Tsuzuki S
Tue Nov 01 00:00:00 UTC 2016
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Verdan FF,Hufford MM,Dent AL,Kaplan MH
Fri Apr 15 00:00:00 UTC 2016
Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1.
Journal of immunology (Baltimore, Md. : 1950)
Li Y,Lu L,Qian S,Fung JJ,Lin F
Mon Feb 15 00:00:00 UTC 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 UTC 2016
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Haribhai D,Ziegelbauer J,Jia S,Upchurch K,Yan K,Schmitt EG,Salzman NH,Simpson P,Hessner MJ,Chatila TA,Williams CB
Fri Apr 15 00:00:00 UTC 2016
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Haribhai D,Ziegelbauer J,Jia S,Upchurch K,Yan K,Schmitt EG,Salzman NH,Simpson P,Hessner MJ,Chatila TA,Williams CB
Fri Apr 15 00:00:00 UTC 2016
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Lo TH,Silveira PA,Fromm PD,Verma ND,Vu PA,Kupresanin F,Adam R,Kato M,Cogger VC,Clark GJ,Hart DN
Mon Aug 01 00:00:00 UTC 2016
Group 2 Innate Lymphoid Cells Promote an Early Antibody Response to a Respiratory Antigen in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Drake LY,Iijima K,Bartemes K,Kita H
Mon Aug 15 00:00:00 UTC 2016
Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis.
Journal of immunology (Baltimore, Md. : 1950)
Liu L,Yi H,Wang C,He H,Li P,Pan H,Sheng N,Ji M,Cai L,Ma Y
Mon Aug 15 00:00:00 UTC 2016
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T
Sat Oct 15 00:00:00 UTC 2016
Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Xiao Y,Shi M,Qiu Q,Huang M,Zeng S,Zou Y,Zhan Z,Liang L,Yang X,Xu H
Wed Jun 15 00:00:00 UTC 2016
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.
Journal of immunology (Baltimore, Md. : 1950)
Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V
Sun May 01 00:00:00 UTC 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 UTC 2016
Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Chua YL,Liong KH,Huang CH,Wong HS,Zhou Q,Ler SS,Tang Y,Low CP,Koh HY,Kuo IC,Zhang Y,Wong WS,Peh HY,Lim HY,Ge MQ,Haczku A,Angeli V,MacAry PA,Chua KY,Kemeny DM
Tue Nov 15 00:00:00 UTC 2016
Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Wu Y,Ren D,Chen GY
Sat Oct 15 00:00:00 UTC 2016
Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E
Fri Apr 01 00:00:00 UTC 2016
STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus.
Journal of immunology (Baltimore, Md. : 1950)
Ding C,Chen X,Dascani P,Hu X,Bolli R,Zhang HG,Mcleish KR,Yan J
Wed Jun 01 00:00:00 UTC 2016
Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Sertorio M,Amarachintha S,Wilson A,Pang Q
Fri Apr 01 00:00:00 UTC 2016
c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor.
Journal of immunology (Baltimore, Md. : 1950)
Gujar R,Maurya N,Yadav V,Gupta M,Arora S,Khatri N,Sen P
Thu Sep 01 00:00:00 UTC 2016
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Subbarayal B,Chauhan SK,Di Zazzo A,Dana R
Tue Nov 01 00:00:00 UTC 2016
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Al Sadoun H,Burgess M,Hentges KE,Mace KA
Mon Aug 01 00:00:00 UTC 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
Fri Apr 01 00:00:00 UTC 2016
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.
Journal of immunology (Baltimore, Md. : 1950)
Kang S,Keener AB,Jones SZ,Benschop RJ,Caro-Maldonado A,Rathmell JC,Clarke SH,Matsushima GK,Whitmire JK,Vilen BJ
Fri Jan 01 00:00:00 UTC 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
214-14 was used in Sample Preparation (FC/FACS) to show that dendritic cells treated with RGMa-neutralising antibodies present with tolerogenic and immunoregulatory characteristics.
Tue Aug 02 00:00:00 UTC 2016
CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.
Biology open
Salao K,Jiang L,Li H,Tsai VW,Husaini Y,Curmi PM,Brown LJ,Brown DA,Breit SN
214-14 was used in In vitro experiments to suggest that CLIC1 regulates DC phagosomal pH to ensure optimal processing of antigen for presentation to antigen-specific T-cells.
Sun May 15 00:00:00 UTC 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
Mon Apr 18 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
Thu Mar 03 00:00:00 UTC 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
Thu Mar 03 00:00:00 UTC 2016
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Nature communications
Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S
Fri Aug 05 00:00:00 UTC 2016
Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.
Nature communications
Saintamand A,Vincent-Fabert C,Garot A,Rouaud P,Oruc Z,Magnone V,Cogné M,Denizot Y
Wed Feb 17 00:00:00 UTC 2016
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system.
Nature communications
Cheong TC,Compagno M,Chiarle R
Wed Mar 09 00:00:00 UTC 2016
Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.
Scientific reports
Wong C,Bezhaeva T,Rothuizen TC,Metselaar JM,de Vries MR,Verbeek FP,Vahrmeijer AL,Wezel A,van Zonneveld AJ,Rabelink TJ,Quax PH,Rotmans JI
Wed Jul 27 00:00:00 UTC 2016
Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.
The Journal of biological chemistry
Takegahara N,Kim H,Mizuno H,Sakaue-Sawano A,Miyawaki A,Tomura M,Kanagawa O,Ishii M,Choi Y
Fri Feb 12 00:00:00 UTC 2016
Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice.
Scientific reports
Yin Y,Zhao L,Zhang F,Zhang X
Mon Aug 22 00:00:00 UTC 2016
Huaier extract suppresses breast cancer via regulating tumor-associated macrophages.
Scientific reports
Li Y,Qi W,Song X,Lv S,Zhang H,Yang Q
Mon Feb 01 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
Bacillus amyloliquefaciens SQR9 induces dendritic cell maturation and enhances the immune response against inactivated avian influenza virus.
Scientific reports
Huang L,Qin T,Yin Y,Gao X,Lin J,Yang Q,Yu Q
Fri Feb 19 00:00:00 UTC 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
Tue Aug 02 00:00:00 UTC 2016
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
The Journal of biological chemistry
Yao Y,Shi Q,Chen B,Wang Q,Li X,Li L,Huang Y,Ji J,Shen P
Fri Aug 12 00:00:00 UTC 2016
Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type II collagen-induced arthritis in mice.
Scientific reports
Fan ZD,Zhang YY,Guo YH,Huang N,Ma HH,Huang H,Yu HG
Mon Oct 24 00:00:00 UTC 2016
Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease.
Scientific reports
Wu XQ,Yang Y,Li WX,Cheng YH,Li XF,Huang C,Meng XM,Wu BM,Liu XH,Zhang L,Lv XW,Li J
Mon Jan 04 00:00:00 UTC 2016
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Nature communications
Schedel M,Jia Y,Michel S,Takeda K,Domenico J,Joetham A,Ning F,Strand M,Han J,Wang M,Lucas JJ,Vogelberg C,Kabesch M,O'Connor BP,Gelfand EW
Mon Jan 11 00:00:00 UTC 2016
Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems.
Scientific reports
Su MJ,Aldawsari H,Amiji M
Fri Jul 22 00:00:00 UTC 2016
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Scientific reports
Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ
Mon May 23 00:00:00 UTC 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
Tue May 17 00:00:00 UTC 2016
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities.
Nature communications
Bain CC,Hawley CA,Garner H,Scott CL,Schridde A,Steers NJ,Mack M,Joshi A,Guilliams M,Mowat AM,Geissmann F,Jenkins SJ
Mon Jun 13 00:00:00 UTC 2016
Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib.
Scientific reports
Gao N,Zhong J,Wang X,Jin Z,Li W,Liu Y,Diao Y,Wang Z,Jiang W,Jin G
Wed Dec 21 00:00:00 UTC 2016
MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
Scientific reports
Moore CE,Pickford J,Cagampang FR,Stead RL,Tian S,Zhao X,Tang X,Byrne CD,Proud CG
Mon Apr 18 00:00:00 UTC 2016
Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis.
Scientific reports
You Y,Zhou C,Li D,Cao ZL,Shen W,Li WZ,Zhang S,Hu B,Shen X
Tue Feb 09 00:00:00 UTC 2016
Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.
Scientific reports
Kim HS,Tavakoli S,Piefer LA,Nguyen HN,Asmis R
Tue Sep 27 00:00:00 UTC 2016
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.
Scientific reports
Huber R,Meier B,Otsuka A,Fenini G,Satoh T,Gehrke S,Widmer D,Levesque MP,Mangana J,Kerl K,Gebhardt C,Fujii H,Nakashima C,Nonomura Y,Kabashima K,Dummer R,Contassot E,French LE
Mon Jul 18 00:00:00 UTC 2016
Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells.
The Journal of biological chemistry
Ali RA,Camick C,Wiles K,Walseth TF,Slama JT,Bhattacharya S,Giovannucci DR,Wall KA
Fri Feb 26 00:00:00 UTC 2016
miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.
Scientific reports
Naqvi AR,Fordham JB,Ganesh B,Nares S
Fri Sep 09 00:00:00 UTC 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Fri Jun 03 00:00:00 UTC 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
Wed Apr 06 00:00:00 UTC 2016
Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways.
Scientific reports
Wang H,Zhang X,Zheng X,Lan Z,Shi J,Jiang J,Zwiep T,Li Q,Quan D,Zhang ZX,Min W
Fri Sep 23 00:00:00 UTC 2016
Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung.
Frontiers in immunology
Zimmer J,Weitnauer M,Boutin S,Küblbeck G,Thiele S,Walker P,Lasitschka F,Lunding L,Orinska Z,Vock C,Arnold B,Wegmann M,Dalpke A
214-14 was used in Cell Culture to study the importance of nuclear translocation of SOCS1 which contains a nuclear localization sequence (NLS) to show that nuclear SOCS1 is a regulator of local immunity in the lung and unravel a so far unrecognized function for SOCS1 in the cell nucleus.
Wed Nov 20 00:00:00 UTC 2019
Bone-protective Functions of Netrin 1 Protein.
The Journal of biological chemistry
Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S
Fri Nov 11 00:00:00 UTC 2016
Pleiotropic action of CpG-ODN on endothelium and macrophages attenuates angiogenesis through distinct pathways.
Scientific reports
Wu J,Su W,Powner MB,Liu J,Copland DA,Fruttiger M,Madeddu P,Dick AD,Liu L
Thu Aug 25 00:00:00 UTC 2016
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
Immunity
Helft J,Böttcher J,Chakravarty P,Zelenay S,Huotari J,Schraml BU,Goubau D,Reis e Sousa C
Tue Jun 16 00:00:00 UTC 2015
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Immunity
Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C
Tue Apr 21 00:00:00 UTC 2015
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Immunity
Jha AK,Huang SC,Sergushichev A,Lampropoulou V,Ivanova Y,Loginicheva E,Chmielewski K,Stewart KM,Ashall J,Everts B,Pearce EJ,Driggers EM,Artyomov MN
Tue Mar 17 00:00:00 UTC 2015
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.
The Journal of clinical investigation
Ouimet M,Ediriweera HN,Gundra UM,Sheedy FJ,Ramkhelawon B,Hutchison SB,Rinehold K,van Solingen C,Fullerton MD,Cecchini K,Rayner KJ,Steinberg GR,Zamore PD,Fisher EA,Loke P,Moore KJ
Mon Oct 26 00:00:00 UTC 2015
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.
The Journal of clinical investigation
Walsh JT,Hendrix S,Boato F,Smirnov I,Zheng J,Lukens JR,Gadani S,Hechler D,Gölz G,Rosenberger K,Kammertöns T,Vogt J,Vogelaar C,Siffrin V,Radjavi A,Fernandez-Castaneda A,Gaultier A,Gold R,Kanneganti TD,Nitsch R,Zipp F,Kipnis J
Sun Feb 01 00:00:00 UTC 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
Mon May 04 00:00:00 UTC 2015
Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
The Journal of experimental medicine
Sekiya T,Kondo T,Shichita T,Morita R,Ichinose H,Yoshimura A
Mon Sep 21 00:00:00 UTC 2015
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
The Journal of experimental medicine
Fiala GJ,Janowska I,Prutek F,Hobeika E,Satapathy A,Sprenger A,Plum T,Seidl M,Dengjel J,Reth M,Cesca F,Brummer T,Minguet S,Schamel WW
Mon Sep 21 00:00:00 UTC 2015
The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression.
Proceedings of the National Academy of Sciences of the United States of America
Choi J,Jeon S,Choi S,Park K,Seong RH
Tue Feb 17 00:00:00 UTC 2015
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America
Svensson MN,Andersson KM,Wasén C,Erlandsson MC,Nurkkala-Karlsson M,Jonsson IM,Brisslert M,Bemark M,Bokarewa MI
Tue Dec 01 00:00:00 UTC 2015
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.
Proceedings of the National Academy of Sciences of the United States of America
Fiebiger BM,Maamary J,Pincetic A,Ravetch JV
Tue May 05 00:00:00 UTC 2015
CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America
Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL
Tue Apr 14 00:00:00 UTC 2015
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proceedings of the National Academy of Sciences of the United States of America
Watschinger K,Keller MA,McNeill E,Alam MT,Lai S,Sailer S,Rauch V,Patel J,Hermetter A,Golderer G,Geley S,Werner-Felmayer G,Plumb RS,Astarita G,Ralser M,Channon KM,Werner ER
Tue Feb 24 00:00:00 UTC 2015
T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C
Tue Apr 07 00:00:00 UTC 2015
Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.
Proceedings of the National Academy of Sciences of the United States of America
Li X,Wang D,Chen Z,Lu E,Wang Z,Duan J,Tian W,Wang Y,You L,Zou Y,Cheng Y,Zhu Q,Wan X,Xi T,Jiang M,Han Y,Cao C,Birnbaumer L,Chu WM,Yang Y
Tue Apr 14 00:00:00 UTC 2015
CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Zheng C,Yang Q,Xu C,Shou P,Cao J,Jiang M,Chen Q,Cao G,Han Y,Li F,Cao W,Zhang L,Zhang L,Shi Y,Wang Y
Tue Dec 29 00:00:00 UTC 2015
CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Zheng C,Yang Q,Xu C,Shou P,Cao J,Jiang M,Chen Q,Cao G,Han Y,Li F,Cao W,Zhang L,Zhang L,Shi Y,Wang Y
Tue Dec 29 00:00:00 UTC 2015
T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Baumann C,Bonilla WV,Fröhlich A,Helmstetter C,Peine M,Hegazy AN,Pinschewer DD,Löhning M
Tue Mar 31 00:00:00 UTC 2015
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
The Journal of cell biology
Terawaki S,Camosseto V,Prete F,Wenger T,Papadopoulos A,Rondeau C,Combes A,Rodriguez Rodrigues C,Vu Manh TP,Fallet M,English L,Santamaria R,Soares AR,Weil T,Hammad H,Desjardins M,Gorvel JP,Santos MA,Gatti E,Pierre P
Mon Sep 28 00:00:00 UTC 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
Wed Apr 01 00:00:00 UTC 2015
The unappreciated intracellular lifestyle of Blastomyces dermatitidis.
Journal of immunology (Baltimore, Md. : 1950)
Sterkel AK,Mettelman R,Wüthrich M,Klein BS
Sun Feb 15 00:00:00 UTC 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
Wed Apr 01 00:00:00 UTC 2015
The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells.
Journal of immunology (Baltimore, Md. : 1950)
Gerasimcik N,Dahlberg CI,Baptista MA,Massaad MJ,Geha RS,Westerberg LS,Severinson E
Fri May 15 00:00:00 UTC 2015
B Cell-Intrinsic IDO1 Regulates Humoral Immunity to T Cell-Independent Antigens.
Journal of immunology (Baltimore, Md. : 1950)
Shinde R,Shimoda M,Chaudhary K,Liu H,Mohamed E,Bradley J,Kandala S,Li X,Liu K,McGaha TL
Tue Sep 01 00:00:00 UTC 2015
TSLP expression: analysis with a ZsGreen TSLP reporter mouse.
Journal of immunology (Baltimore, Md. : 1950)
Dewas C,Chen X,Honda T,Junttila I,Linton J,Udey MC,Porcella SF,Sturdevant DE,Feigenbaum L,Koo L,Williams J,Paul WE
Sun Feb 01 00:00:00 UTC 2015
Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region.
Journal of immunology (Baltimore, Md. : 1950)
He M,Cortizas EM,Verdun RE,Severinson E
Fri May 01 00:00:00 UTC 2015
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB
Tue Dec 15 00:00:00 UTC 2015
An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu H,Xu LL,Teuscher P,Liu H,Kaplan MH,Dent AL
Tue Sep 01 00:00:00 UTC 2015
Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Suzuki M,Morita R,Hirata Y,Shichita T,Yoshimura A
Sat Aug 01 00:00:00 UTC 2015
JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.
Journal of immunology (Baltimore, Md. : 1950)
Kitabatake M,Soma M,Zhang T,Kuwahara K,Fukushima Y,Nojima T,Kitamura D,Sakaguchi N
Sun Feb 15 00:00:00 UTC 2015
Extracorporeal photopheresis promotes IL-1β production.
Journal of immunology (Baltimore, Md. : 1950)
Yakut E,Jakobs C,Peric A,Michel G,Baal N,Bein G,Brüne B,Hornung V,Hackstein H
Sun Mar 15 00:00:00 UTC 2015
Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)
Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S
Wed Apr 01 00:00:00 UTC 2015
JUNB is a key transcriptional modulator of macrophage activation.
Journal of immunology (Baltimore, Md. : 1950)
Fontana MF,Baccarella A,Pancholi N,Pufall MA,Herbert DR,Kim CC
Thu Jan 01 00:00:00 UTC 2015
Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Chen G,Liu Z,Tian S,Zhang J,Carey CD,Murphy KM,Storkus WJ,Falo LD,You Z
Mon Jun 15 00:00:00 UTC 2015
Thymic low affinity/avidity interaction selects natural Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Kang BH,Park HJ,Yum HI,Park SP,Park JK,Kang EH,Lee JI,Lee EB,Park CG,Jung KC,Park SH
Mon Jun 15 00:00:00 UTC 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
Thu Oct 01 00:00:00 UTC 2015
Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.
Journal of immunology (Baltimore, Md. : 1950)
Ackermann JA,Nys J,Schweighoffer E,McCleary S,Smithers N,Tybulewicz VL
Fri May 15 00:00:00 UTC 2015
Collaborative interactions between type 2 innate lymphoid cells and antigen-specific CD4+ Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Lee JB,Chen CY,Hershey GK,Wang YH
Wed Apr 15 00:00:00 UTC 2015
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP
Sun Feb 01 00:00:00 UTC 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 UTC 2015
IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Gorbacheva V,Fan R,Wang X,Baldwin WM,Fairchild RL,Valujskikh A
Sun Feb 01 00:00:00 UTC 2015
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bornancin F,Renner F,Touil R,Sic H,Kolb Y,Touil-Allaoui I,Rush JS,Smith PA,Bigaud M,Junker-Walker U,Burkhart C,Dawson J,Niwa S,Katopodis A,Nuesslein-Hildesheim B,Weckbecker G,Zenke G,Kinzel B,Traggiai E,Brenner D,Brüstle A,St Paul M,Zamurovic N,McCoy KD,Rolink A,Régnier CH,Mak TW,Ohashi PS,Patel DD,Calzascia T
Wed Apr 15 00:00:00 UTC 2015
Uric acid enhances the antitumor immunity of dendritic cell-based vaccine.
Scientific reports
Wang Y,Ma X,Su C,Peng B,Du J,Jia H,Luo M,Fang C,Wei Y
Tue Nov 10 00:00:00 UTC 2015
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Nature communications
Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E
Mon Oct 05 00:00:00 UTC 2015
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin.
Cell death & disease
Tan HY,Wang N,Man K,Tsao SW,Che CM,Feng Y
Thu Oct 22 00:00:00 UTC 2015
AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.
Nature communications
Herter JM,Grabie N,Cullere X,Azcutia V,Rosetti F,Bennett P,Herter-Sprie GS,Elyaman W,Luscinskas FW,Lichtman AH,Mayadas TN
Fri Dec 18 00:00:00 UTC 2015
CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.
Scientific reports
Wang C,Liu X,Li Z,Chai Y,Jiang Y,Wang Q,Ji Y,Zhu Z,Wan Y,Yuan Z,Chang Z,Zhang M
Tue Sep 15 00:00:00 UTC 2015
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Nature communications
Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS
Fri Apr 24 00:00:00 UTC 2015
Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles.
Scientific reports
Tran TH,Rastogi R,Shelke J,Amiji MM
Wed Nov 18 00:00:00 UTC 2015
Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.
Scientific reports
Khabbazi S,Goumon Y,Parat MO
Tue Jun 16 00:00:00 UTC 2015
Estrogen accelerates the resolution of inflammation in macrophagic cells.
Scientific reports
Villa A,Rizzi N,Vegeto E,Ciana P,Maggi A
Mon Oct 19 00:00:00 UTC 2015
Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.
Nature communications
Sumida T,Naito AT,Nomura S,Nakagawa A,Higo T,Hashimoto A,Okada K,Sakai T,Ito M,Yamaguchi T,Oka T,Akazawa H,Lee JK,Minamino T,Offermanns S,Noda T,Botto M,Kobayashi Y,Morita H,Manabe I,Nagai T,Shiojima I,Komuro I
Thu Feb 26 00:00:00 UTC 2015
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Cell
Li X,Liang Y,LeBlanc M,Benner C,Zheng Y
Thu Aug 14 00:00:00 UTC 2014
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
Cell
Qiu Y,Nguyen KD,Odegaard JI,Cui X,Tian X,Locksley RM,Palmiter RD,Chawla A
Thu Jun 05 00:00:00 UTC 2014
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Cell
Rao RR,Long JZ,White JP,Svensson KJ,Lou J,Lokurkar I,Jedrychowski MP,Ruas JL,Wrann CD,Lo JC,Camera DM,Lachey J,Gygi S,Seehra J,Hawley JA,Spiegelman BM
Thu Jun 05 00:00:00 UTC 2014
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Immunity
Shouval DS,Biswas A,Goettel JA,McCann K,Conaway E,Redhu NS,Mascanfroni ID,Al Adham Z,Lavoie S,Ibourk M,Nguyen DD,Samsom JN,Escher JC,Somech R,Weiss B,Beier R,Conklin LS,Ebens CL,Santos FG,Ferreira AR,Sherlock M,Bhan AK,Müller W,Mora JR,Quintana FJ,Klein C,Muise AM,Horwitz BH,Snapper SB
Thu May 15 00:00:00 UTC 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
214-14 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 UTC 2014
Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1.
Blood
Won H,Nandakumar V,Yates P,Sanchez S,Jones L,Huang XF,Chen SY
Thu Oct 23 00:00:00 UTC 2014
Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis.
The Journal of clinical investigation
Califano D,Sweeney KJ,Le H,VanValkenburgh J,Yager E,O'Connor W,Kennedy JS,Jones DM,Avram D
Wed Jan 01 00:00:00 UTC 2014
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.
The Journal of clinical investigation
Dahdah A,Gautier G,Attout T,Fiore F,Lebourdais E,Msallam R,Daëron M,Monteiro RC,Benhamou M,Charles N,Davoust J,Blank U,Malissen B,Launay P
Wed Oct 01 00:00:00 UTC 2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
The Journal of experimental medicine
Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L
Mon Dec 15 00:00:00 UTC 2014
Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
The Journal of experimental medicine
Rouaud P,Saintamand A,Saad F,Carrion C,Lecardeur S,Cogné M,Denizot Y
Mon May 05 00:00:00 UTC 2014
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Visekruna A,Papoutsopoulou S,Janzen J,Zillwood R,Tarlinton DM,Tybulewicz VL,Ley SC
Mon Sep 22 00:00:00 UTC 2014
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
The Journal of experimental medicine
Tanaka S,Suto A,Iwamoto T,Kashiwakuma D,Kagami S,Suzuki K,Takatori H,Tamachi T,Hirose K,Onodera A,Suzuki J,Ohara O,Yamashita M,Nakayama T,Nakajima H
Mon Aug 25 00:00:00 UTC 2014
CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
The Journal of experimental medicine
Jia XM,Tang B,Zhu LL,Liu YH,Zhao XQ,Gorjestani S,Hsu YM,Yang L,Guan JH,Xu GT,Lin X
Mon Oct 20 00:00:00 UTC 2014
Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.
The Journal of experimental medicine
Nguyen TV,Riou L,Aoufouchi S,Rosselli F
Mon Jun 02 00:00:00 UTC 2014
IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.
Proceedings of the National Academy of Sciences of the United States of America
Gostissa M,Schwer B,Chang A,Dong J,Meyers RM,Marecki GT,Choi VW,Chiarle R,Zarrin AA,Alt FW
Tue Feb 18 00:00:00 UTC 2014
FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Clatworthy MR,Harford SK,Mathews RJ,Smith KG
Tue Dec 16 00:00:00 UTC 2014
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.
Proceedings of the National Academy of Sciences of the United States of America
Liao W,Spolski R,Li P,Du N,West EE,Ren M,Mitra S,Leonard WJ
Tue Mar 04 00:00:00 UTC 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 UTC 2014
Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proceedings of the National Academy of Sciences of the United States of America
Brennan PJ,Tatituri RV,Heiss C,Watts GF,Hsu FF,Veerapen N,Cox LR,Azadi P,Besra GS,Brenner MB
Tue Sep 16 00:00:00 UTC 2014
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
Proceedings of the National Academy of Sciences of the United States of America
Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS
Tue Jul 29 00:00:00 UTC 2014
Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America
Wang D,Fu L,Ning W,Guo L,Sun X,Dey SK,Chaturvedi R,Wilson KT,DuBois RN
Tue May 13 00:00:00 UTC 2014
Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Mackenzie KJ,Nowakowska DJ,Leech MD,McFarlane AJ,Wilson C,Fitch PM,O'Connor RA,Howie SE,Schwarze J,Anderton SM
Tue Feb 25 00:00:00 UTC 2014
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease.
Cell death and differentiation
Tang Y,Li T,Li J,Yang J,Liu H,Zhang XJ,Le W
Sat Mar 01 00:00:00 UTC 2014
Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib.
The Journal of investigative dermatology
Okiyama N,Furumoto Y,Villarroel VA,Linton JT,Tsai WL,Gutermuth J,Ghoreschi K,Gadina M,O'Shea JJ,Katz SI
Tue Apr 01 00:00:00 UTC 2014
Antigen-dependent versus -independent activation of invariant NKT cells during infection.
Journal of immunology (Baltimore, Md. : 1950)
Holzapfel KL,Tyznik AJ,Kronenberg M,Hogquist KA
Sun Jun 15 00:00:00 UTC 2014
IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.
Journal of immunology (Baltimore, Md. : 1950)
Attridge K,Kenefeck R,Wardzinski L,Qureshi OS,Wang CJ,Manzotti C,Okkenhaug K,Walker LS
Sat Mar 01 00:00:00 UTC 2014
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kim KD,Srikanth S,Tan YV,Yee MK,Jew M,Damoiseaux R,Jung ME,Shimizu S,An DS,Ribalet B,Waschek JA,Gwack Y
Wed Jan 01 00:00:00 UTC 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
Tue Jul 15 00:00:00 UTC 2014
MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Cheng Q,Zhang Q,Xu X,Yin L,Sun L,Lin X,Dong C,Pan W
Tue Apr 15 00:00:00 UTC 2014
Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Oksanen A,Aittomäki S,Jankovic D,Ortutay Z,Pulkkinen K,Hämäläinen S,Rokka A,Corthals GL,Watford WT,Junttila I,O'Shea JJ,Pesu M
Mon Dec 01 00:00:00 UTC 2014
6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
So JS,Kim GC,Song M,Lee CG,Park E,Kim HJ,Kim YS,Jun CD,Im SH
Mon Sep 15 00:00:00 UTC 2014
IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation.
Journal of immunology (Baltimore, Md. : 1950)
Fulkerson PC,Schollaert KL,Bouffi C,Rothenberg ME
Wed Oct 15 00:00:00 UTC 2014
1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.
Journal of immunology (Baltimore, Md. : 1950)
Ferreira GB,Gysemans CA,Demengeot J,da Cunha JP,Vanherwegen AS,Overbergh L,Van Belle TL,Pauwels F,Verstuyf A,Korf H,Mathieu C
Thu May 01 00:00:00 UTC 2014
gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.
Journal of immunology (Baltimore, Md. : 1950)
Fukao S,Haniuda K,Nojima T,Takai T,Kitamura D
Tue Jul 15 00:00:00 UTC 2014
Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Le TT,Karmouty-Quintana H,Melicoff E,Le TT,Weng T,Chen NY,Pedroza M,Zhou Y,Davies J,Philip K,Molina J,Luo F,George AT,Garcia-Morales LJ,Bunge RR,Bruckner BA,Loebe M,Seethamraju H,Agarwal SK,Blackburn MR
Wed Oct 01 00:00:00 UTC 2014
Themis2 is not required for B cell development, activation, and antibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Hartweger H,Schweighoffer E,Davidson S,Peirce MJ,Wack A,Tybulewicz VL
Tue Jul 15 00:00:00 UTC 2014
Th17 cells demonstrate stable cytokine production in a proallergic environment.
Journal of immunology (Baltimore, Md. : 1950)
Glosson-Byers NL,Sehra S,Stritesky GL,Yu Q,Awe O,Pham D,Bruns HA,Kaplan MH
Mon Sep 15 00:00:00 UTC 2014
Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Pawaria S,Ramani K,Maers K,Liu Y,Kane LP,Levesque MC,Biswas PS
Wed Oct 01 00:00:00 UTC 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
Wed Jan 01 00:00:00 UTC 2014
Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine Mycoplasma pneumonia.
Journal of immunology (Baltimore, Md. : 1950)
Dobbs NA,Zhou X,Pulse M,Hodge LM,Schoeb TR,Simecka JW
Fri Aug 01 00:00:00 UTC 2014
A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950)
Dahlberg CI,He M,Visnes T,Torres ML,Cortizas EM,Verdun RE,Westerberg LS,Severinson E,Ström L
Sat Nov 01 00:00:00 UTC 2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Nature communications
Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M
Tue Nov 24 00:00:00 UTC 2015
Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.
The Journal of biological chemistry
He L,Marneros AG
Fri Mar 21 00:00:00 UTC 2014
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 UTC 2014
Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.
The Journal of biological chemistry
Gaudette BT,Iwakoshi NN,Boise LH
Fri Aug 22 00:00:00 UTC 2014
The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation.
The Journal of biological chemistry
Chen K,Xiang Y,Huang J,Gong W,Yoshimura T,Jiang Q,Tessarollo L,Le Y,Wang JM
Fri Jun 20 00:00:00 UTC 2014
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Cell death & disease
Través PG,Pardo V,Pimentel-Santillana M,González-Rodríguez Á,Mojena M,Rico D,Montenegro Y,Calés C,Martín-Sanz P,Valverde AM,Boscá L
Thu Mar 13 00:00:00 UTC 2014
γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages.
The Journal of biological chemistry
Balce DR,Allan ERO,McKenna N,Yates RM
Fri Nov 14 00:00:00 UTC 2014
A regenerative approach to the treatment of multiple sclerosis.
Nature
Deshmukh VA,Tardif V,Lyssiotis CA,Green CC,Kerman B,Kim HJ,Padmanabhan K,Swoboda JG,Ahmad I,Kondo T,Gage FH,Theofilopoulos AN,Lawson BR,Schultz PG,Lairson LL
Thu Oct 17 00:00:00 UTC 2013
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Cell
Heredia JE,Mukundan L,Chen FM,Mueller AA,Deo RC,Locksley RM,Rando TA,Chawla A
Thu Apr 11 00:00:00 UTC 2013
Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
Immunity
Spence S,Fitzsimons A,Boyd CR,Kessler J,Fitzgerald D,Elliott J,Gabhann JN,Smith S,Sica A,Hams E,Saunders SP,Jefferies CA,Fallon PG,McAuley DF,Kissenpfennig A,Johnston JA
Thu Jan 24 00:00:00 UTC 2013
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
Blood
Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S
Thu Feb 28 00:00:00 UTC 2013
Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.
Blood
Tinsley KW,Hong C,Luckey MA,Park JY,Kim GY,Yoon HW,Keller HR,Sacks AJ,Feigenbaum L,Park JH
Thu Oct 03 00:00:00 UTC 2013
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.
Blood
Rafei M,Rouette A,Brochu S,Vanegas JR,Perreault C
Thu Jan 03 00:00:00 UTC 2013
Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9.
Blood
Zajac E,Schweighofer B,Kupriyanova TA,Juncker-Jensen A,Minder P,Quigley JP,Deryugina EI
Thu Dec 12 00:00:00 UTC 2013
Cognate antigen directs CD8+ T cell migration to vascularized transplants.
The Journal of clinical investigation
Walch JM,Zeng Q,Li Q,Oberbarnscheidt MH,Hoffman RA,Williams AL,Rothstein DM,Shlomchik WD,Kim JV,Camirand G,Lakkis FG
Sat Jun 01 00:00:00 UTC 2013
BET bromodomain inhibition suppresses TH17-mediated pathology.
The Journal of experimental medicine
Mele DA,Salmeron A,Ghosh S,Huang HR,Bryant BM,Lora JM
214-14 was used in Cell Culture to identify BET proteins as a fundamental link between chromatin signalling and T(H)17 biology.
Mon Oct 21 00:00:00 UTC 2013
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
The Journal of experimental medicine
Maruyama K,Uematsu S,Kondo T,Takeuchi O,Martino MM,Kawasaki T,Akira S
Mon Sep 23 00:00:00 UTC 2013
ATG5 regulates plasma cell differentiation.
Autophagy
Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ
214-14 was used in In vitro experiments to study mice deficient in ATG5 in T and B cell development function.
Mon Apr 01 00:00:00 UTC 2013
Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Wermeling F,Anthony RM,Brombacher F,Ravetch JV
Tue Aug 13 00:00:00 UTC 2013
Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Wermeling F,Anthony RM,Brombacher F,Ravetch JV
Tue Aug 13 00:00:00 UTC 2013
Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Li J,Wei B,Guo A,Liu C,Huang S,Du F,Fan W,Bao C,Pei G
Tue Apr 30 00:00:00 UTC 2013
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH
Tue Feb 05 00:00:00 UTC 2013
Eosinophils secrete IL-4 to facilitate liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Goh YP,Henderson NC,Heredia JE,Red Eagle A,Odegaard JI,Lehwald N,Nguyen KD,Sheppard D,Mukundan L,Locksley RM,Chawla A
Tue Jun 11 00:00:00 UTC 2013
Eosinophils secrete IL-4 to facilitate liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Goh YP,Henderson NC,Heredia JE,Red Eagle A,Odegaard JI,Lehwald N,Nguyen KD,Sheppard D,Mukundan L,Locksley RM,Chawla A
Tue Jun 11 00:00:00 UTC 2013
A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations.
Proceedings of the National Academy of Sciences of the United States of America
Murphy SC,Kas A,Stone BC,Bevan MJ
Tue Apr 09 00:00:00 UTC 2013
Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Proceedings of the National Academy of Sciences of the United States of America
Swee LK,Guimaraes CP,Sehrawat S,Spooner E,Barrasa MI,Ploegh HL
Tue Jan 22 00:00:00 UTC 2013
Lymphocyte-derived ACh regulates local innate but not adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America
Reardon C,Duncan GS,Brüstle A,Brenner D,Tusche MW,Olofsson PS,Rosas-Ballina M,Tracey KJ,Mak TW
Tue Jan 22 00:00:00 UTC 2013
Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion.
PLoS pathogens
Worthington JJ,Samuelson LC,Grencis RK,McLaughlin JT
Tue Jan 01 00:00:00 UTC 2013
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.
PLoS pathogens
Lazear HM,Lancaster A,Wilkins C,Suthar MS,Huang A,Vick SC,Clepper L,Thackray L,Brassil MM,Virgin HW,Nikolich-Zugich J,Moses AV,Gale M,Früh K,Diamond MS
Tue Jan 01 00:00:00 UTC 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 UTC 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 UTC 2013
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM
Sat Jun 01 00:00:00 UTC 2013
Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.
Journal of immunology (Baltimore, Md. : 1950)
Lo YC,Edidin MA,Powell JD
Fri Nov 15 00:00:00 UTC 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 UTC 2013
Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.
Journal of immunology (Baltimore, Md. : 1950)
Waddell A,Ahrens R,Tsai YT,Sherrill JD,Denson LA,Steinbrecher KA,Hogan SP
Wed May 01 00:00:00 UTC 2013
Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation process.
Journal of immunology (Baltimore, Md. : 1950)
Mikami N,Miyagi Y,Sueda K,Takatsuji M,Fukada S,Yamamoto H,Tsujikawa K
Mon Apr 15 00:00:00 UTC 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
Mon Apr 15 00:00:00 UTC 2013
Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation.
Journal of immunology (Baltimore, Md. : 1950)
Hirai T,Kanda T,Sato K,Takaishi M,Nakajima K,Yamamoto M,Kamijima R,Digiovanni J,Sano S
Wed May 01 00:00:00 UTC 2013
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Journal of immunology (Baltimore, Md. : 1950)
Beurel E,Kaidanovich-Beilin O,Yeh WI,Song L,Palomo V,Michalek SM,Woodgett JR,Harrington LE,Eldar-Finkelman H,Martinez A,Jope RS
Wed May 15 00:00:00 UTC 2013
Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Zahn A,Daugan M,Safavi S,Godin D,Cheong C,Lamarre A,Di Noia JM
Sat Jun 15 00:00:00 UTC 2013
Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Jia Y,Takeda K,Han J,Joetham A,Marcus RA,Lucas JJ,O'Connor BP,Gelfand EW
Mon Apr 15 00:00:00 UTC 2013
Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury.
Journal of immunology (Baltimore, Md. : 1950)
Craig VJ,Quintero PA,Fyfe SE,Patel AS,Knolle MD,Kobzik L,Owen CA
Mon Apr 15 00:00:00 UTC 2013
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
Sun Dec 01 00:00:00 UTC 2013
Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Pascual-García M,Rué L,León T,Julve J,Carbó JM,Matalonga J,Auer H,Celada A,Escolà-Gil JC,Steffensen KR,Pérez-Navarro E,Valledor AF
Sat Jun 15 00:00:00 UTC 2013
Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
Journal of immunology (Baltimore, Md. : 1950)
Tamiya T,Ichiyama K,Kotani H,Fukaya T,Sekiya T,Shichita T,Honma K,Yui K,Matsuyama T,Nakao T,Fukuyama S,Inoue H,Nomura M,Yoshimura A
Sun Sep 01 00:00:00 UTC 2013
Adam8 limits the development of allergic airway inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA
Sat Jun 15 00:00:00 UTC 2013
Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice.
Journal of immunology (Baltimore, Md. : 1950)
Ng RL,Scott NM,Strickland DH,Gorman S,Grimbaldeston MA,Norval M,Waithman J,Hart PH
Sat Jun 01 00:00:00 UTC 2013
Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.
Journal of immunology (Baltimore, Md. : 1950)
Yeung MY,McGrath MM,Nakayama M,Shimizu T,Boenisch O,Magee CN,Abdoli R,Akiba H,Ueno T,Turka LA,Najafian N
Tue Oct 15 00:00:00 UTC 2013
Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination.
Journal of immunology (Baltimore, Md. : 1950)
Cortizas EM,Zahn A,Hajjar ME,Patenaude AM,Di Noia JM,Verdun RE
Sun Dec 01 00:00:00 UTC 2013
Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sivaganesh S,Harper SJ,Conlon TM,Callaghan CJ,Saeb-Parsy K,Negus MC,Motallebzadeh R,Bolton EM,Bradley JA,Pettigrew GJ
Sat Jun 01 00:00:00 UTC 2013
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Journal of immunology (Baltimore, Md. : 1950)
Mok Y,Schwierzeck V,Thomas DC,Vigorito E,Rayner TF,Jarvis LB,Prosser HM,Bradley A,Withers DR,Mårtensson IL,Corcoran LM,Blenkiron C,Miska EA,Lyons PA,Smith KGC
Sun Sep 15 00:00:00 UTC 2013
Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Han H,Headley MB,Xu W,Comeau MR,Zhou B,Ziegler SF
Fri Feb 01 00:00:00 UTC 2013
Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α.
Journal of immunology (Baltimore, Md. : 1950)
Wejksza K,Lee-Chang C,Bodogai M,Bonzo J,Gonzalez FJ,Lehrmann E,Becker K,Biragyn A
Fri Mar 15 00:00:00 UTC 2013
Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse.
Journal of immunology (Baltimore, Md. : 1950)
Saez de Guinoa J,Barrio L,Carrasco YR
Sun Sep 01 00:00:00 UTC 2013
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.
Journal of immunology (Baltimore, Md. : 1950)
Bouffi C,Rochman M,Zust CB,Stucke EM,Kartashov A,Fulkerson PC,Barski A,Rothenberg ME
Tue Oct 15 00:00:00 UTC 2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
Tue Oct 01 00:00:00 UTC 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 UTC 2013
Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kawashima H,Takatori H,Suzuki K,Iwata A,Yokota M,Suto A,Minamino T,Hirose K,Nakajima H
Tue Oct 01 00:00:00 UTC 2013
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Guo Z,Khattar M,Schroder PM,Miyahara Y,Wang G,He X,Chen W,Stepkowski SM
Mon Apr 01 00:00:00 UTC 2013
PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Chang HH,Miaw SC,Tseng W,Sun YW,Liu CC,Tsao HW,Ho IC
Sun Sep 01 00:00:00 UTC 2013
PU.1-dependent transcriptional regulation of miR-142 contributes to its hematopoietic cell-specific expression and modulation of IL-6.
Journal of immunology (Baltimore, Md. : 1950)
Sun Y,Sun J,Tomomi T,Nieves E,Mathewson N,Tamaki H,Evers R,Reddy P
Mon Apr 15 00:00:00 UTC 2013
Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Yonsei medical journal
Ji B,Chen Q,Liu B,Wu L,Tian D,Guo Z,Yi W
Tue Jan 01 00:00:00 UTC 2013
Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER).
The Journal of biological chemistry
Reithinger JH,Kim JE,Kim H
Fri Jun 21 00:00:00 UTC 2013
Orientia tsutsugamushi subverts dendritic cell functions by escaping from autophagy and impairing their migration.
PLoS neglected tropical diseases
Choi JH,Cheong TC,Ha NY,Ko Y,Cho CH,Jeon JH,So I,Kim IK,Choi MS,Kim IS,Cho NH
Wed Jun 19 00:00:00 UTC 2013
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
The Journal of biological chemistry
Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH
Fri Sep 20 00:00:00 UTC 2013
B cell-specific deficiencies in mTOR limit humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhang S,Pruitt M,Tran D,Du Bois W,Zhang K,Patel R,Hoover S,Simpson RM,Simmons J,Gary J,Snapper CM,Casellas R,Mock BA
214-14 was used in In vitro experiments to shows that mTOR plays an important immunoregulatory role in the germinal centre, at least partially through activation-induced cytidine deaminase signalling, in generating high-affinity antibodies.
Thu Aug 15 00:00:00 UTC 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 UTC 2013
Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.
Immunity
Rao RR,Li Q,Gubbels Bupp MR,Shrikant PA
Fri Mar 23 00:00:00 UTC 2012
The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.
Immunity
Harada Y,Tanaka S,Motomura Y,Harada Y,Ohno S,Ohno S,Yanagi Y,Inoue H,Kubo M
Fri Feb 24 00:00:00 UTC 2012
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.
Blood
Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M
Thu Jan 12 00:00:00 UTC 2012
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood
Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ
Thu Jun 21 00:00:00 UTC 2012
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.
Blood
Westerberg LS,Dahlberg C,Baptista M,Moran CJ,Detre C,Keszei M,Eston MA,Alt FW,Terhorst C,Notarangelo LD,Snapper SB
Thu Apr 26 00:00:00 UTC 2012
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood
Fares J,Koller R,Humeniuk R,Wolff L,Bies J
Thu May 24 00:00:00 UTC 2012
Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.
Blood
Rückerl D,Jenkins SJ,Laqtom NN,Gallagher IJ,Sutherland TE,Duncan S,Buck AH,Allen JE
Thu Sep 13 00:00:00 UTC 2012
Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L.
Blood
Qian L,Qian C,Chen Y,Bai Y,Bao Y,Lu L,Cao X
Thu Jul 19 00:00:00 UTC 2012
TNF signaling drives myeloid-derived suppressor cell accumulation.
The Journal of clinical investigation
Zhao X,Rong L,Zhao X,Li X,Liu X,Deng J,Wu H,Xu X,Erben U,Wu P,Syrbe U,Sieper J,Qin Z
Thu Nov 01 00:00:00 UTC 2012
Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
The Journal of clinical investigation
Masuoka M,Shiraishi H,Ohta S,Suzuki S,Arima K,Aoki S,Toda S,Inagaki N,Kurihara Y,Hayashida S,Takeuchi S,Koike K,Ono J,Noshiro H,Furue M,Conway SJ,Narisawa Y,Izuhara K
Sun Jul 01 00:00:00 UTC 2012
Viral acute lower respiratory infections impair CD8+ T cells through PD-1.
The Journal of clinical investigation
Erickson JJ,Gilchuk P,Hastings AK,Tollefson SJ,Johnson M,Downing MB,Boyd KL,Johnson JE,Kim AS,Joyce S,Williams JV
Wed Aug 01 00:00:00 UTC 2012
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation
Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW
Sat Dec 01 00:00:00 UTC 2012
UNG shapes the specificity of AID-induced somatic hypermutation.
The Journal of experimental medicine
Pérez-Durán P,Belver L,de Yébenes VG,Delgado P,Pisano DG,Ramiro AR
Mon Jul 02 00:00:00 UTC 2012
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
The Journal of experimental medicine
Hao Z,Duncan GS,Su YW,Li WY,Silvester J,Hong C,You H,Brenner D,Gorrini C,Haight J,Wakeham A,You-Ten A,McCracken S,Elia A,Li Q,Detmar J,Jurisicova A,Hobeika E,Reth M,Sheng Y,Lang PA,Ohashi PS,Zhong Q,Wang X,Mak TW
Mon Jan 16 00:00:00 UTC 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 UTC 2012
Coreceptor gene imprinting governs thymocyte lineage fate.
The EMBO journal
Adoro S,McCaughtry T,Erman B,Alag A,Van Laethem F,Park JH,Tai X,Kimura M,Wang L,Grinberg A,Kubo M,Bosselut R,Love P,Singer A
Wed Jan 18 00:00:00 UTC 2012
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Proceedings of the National Academy of Sciences of the United States of America
Benson MJ,Aijö T,Chang X,Gagnon J,Pape UJ,Anantharaman V,Aravind L,Pursiheimo JP,Oberdoerffer S,Liu XS,Lahesmaa R,Lähdesmäki H,Rao A
Tue Oct 02 00:00:00 UTC 2012
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Mandl JN,Liou R,Klauschen F,Vrisekoop N,Monteiro JP,Yates AJ,Huang AY,Germain RN
Tue Oct 30 00:00:00 UTC 2012
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Cook PC,Jones LH,Jenkins SJ,Wynn TA,Allen JE,MacDonald AS
Tue Jun 19 00:00:00 UTC 2012
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Clark K,MacKenzie KF,Petkevicius K,Kristariyanto Y,Zhang J,Choi HG,Peggie M,Plater L,Pedrioli PG,McIver E,Gray NS,Arthur JS,Cohen P
Tue Oct 16 00:00:00 UTC 2012
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P
Mon Dec 17 00:00:00 UTC 2012
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P
Mon Dec 17 00:00:00 UTC 2012
Effects of interferon-α-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors.
Cancer gene therapy
Omori R,Eguchi J,Hiroishi K,Ishii S,Hiraide A,Sakaki M,Doi H,Kajiwara A,Ito T,Kogo M,Imawari M
Sat Sep 01 00:00:00 UTC 2012
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YG,Wang Y,Guo Z,Gu AD,Dan HC,Baldwin AS,Hao W,Wan YY
Thu Nov 01 00:00:00 UTC 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 UTC 2012
Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ventre E,Brinza L,Schicklin S,Mafille J,Coupet CA,Marçais A,Djebali S,Jubin V,Walzer T,Marvel J
Mon Oct 01 00:00:00 UTC 2012
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950)
Shankar SP,Wilson MS,DiVietro JA,Mentink-Kane MM,Xie Z,Wynn TA,Druey KM
Fri Jun 15 00:00:00 UTC 2012
SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Bediako Y,Bian Y,Zhang H,Cho H,Stein PL,Wang CR
Thu Nov 15 00:00:00 UTC 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
Thu Mar 01 00:00:00 UTC 2012
CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors.
Journal of immunology (Baltimore, Md. : 1950)
Blonska M,Joo D,Zweidler-McKay PA,Zhao Q,Lin X
Sun Apr 01 00:00:00 UTC 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 UTC 2012
Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR
Mon Oct 15 00:00:00 UTC 2012
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Morita H,Nambu A,Arae K,Shimura E,Shibui A,Yamaguchi S,Suzukawa K,Nakanishi W,Oboki K,Kajiwara N,Ohno T,Ishii A,Körner H,Cua DJ,Suto H,Yoshimoto T,Iwakura Y,Yamasoba T,Ohta K,Sudo K,Saito H,Okumura K,Broide DH,Matsumoto K,Nakae S
Mon Oct 01 00:00:00 UTC 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 UTC 2012
Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Dervovic DD,Ciofani M,Kianizad K,Zúñiga-Pflücker JC
Mon Oct 01 00:00:00 UTC 2012
Dynamics of the splenic innate-like CD19⁺CD45Rlo cell population from adult mice in homeostatic and activated conditions.
Journal of immunology (Baltimore, Md. : 1950)
de Andrés B,Prado C,Palacios B,Alía M,Jagtap S,Serrano N,Cortegano I,Marcos MA,Gaspar ML
Sat Sep 01 00:00:00 UTC 2012
Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-γ and nitric oxide.
Journal of immunology (Baltimore, Md. : 1950)
Xu X,Yi H,Guo Z,Qian C,Xia S,Yao Y,Cao X
Wed Feb 01 00:00:00 UTC 2012
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.
Journal of immunology (Baltimore, Md. : 1950)
Goswami R,Kaplan MH
Sat Sep 15 00:00:00 UTC 2012
Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.
Journal of immunology (Baltimore, Md. : 1950)
Volpi SA,Verma-Gaur J,Hassan R,Ju Z,Roa S,Chatterjee S,Werling U,Hou H,Will B,Steidl U,Scharff M,Edelman W,Feeney AJ,Birshtein BK
Thu Mar 15 00:00:00 UTC 2012
Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Ju W,Yao Z,Yu P,Wei BR,Simpson RM,Waitz R,Fassò M,Allison JP,Waldmann TA
Fri Jun 15 00:00:00 UTC 2012
Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Emo J,Meednu N,Chapman TJ,Rezaee F,Balys M,Randall T,Rangasamy T,Georas SN
Sun Apr 15 00:00:00 UTC 2012
Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Swartzendruber JA,Byrne AJ,Bryce PJ
Sun Jan 15 00:00:00 UTC 2012
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
Journal of immunology (Baltimore, Md. : 1950)
Verma-Gaur J,Hauser J,Grundström T
Fri Jun 15 00:00:00 UTC 2012
STAT6-dependent regulation of Th9 development.
Journal of immunology (Baltimore, Md. : 1950)
Goswami R,Jabeen R,Yagi R,Pham D,Zhu J,Goenka S,Kaplan MH
Wed Feb 01 00:00:00 UTC 2012
Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells.
Journal of immunology (Baltimore, Md. : 1950)
Sissons JR,Peschon JJ,Schmitz F,Suen R,Gilchrist M,Aderem A
Sun Jul 01 00:00:00 UTC 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 UTC 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
Sun Jan 01 00:00:00 UTC 2012
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gilbert MR,Wagner NJ,Jones SZ,Wisz AB,Roques JR,Krum KN,Lee SR,Nickeleit V,Hulbert C,Thomas JW,Gauld SB,Vilen BJ
Sun Jul 15 00:00:00 UTC 2012
Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee CG,Kwon HK,Sahoo A,Hwang W,So JS,Hwang JS,Chae CS,Kim GC,Kim JE,So HS,Hwang ES,Grenningloh R,Ho IC,Im SH
Thu Mar 01 00:00:00 UTC 2012
FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.
Journal of immunology (Baltimore, Md. : 1950)
Amezcua Vesely MC,Schwartz M,Bermejo DA,Montes CL,Cautivo KM,Kalergis AM,Rawlings DJ,Acosta-Rodríguez EV,Gruppi A
Tue May 15 00:00:00 UTC 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Sat Sep 01 00:00:00 UTC 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 UTC 2012
Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Ioannou M,Alissafi T,Lazaridis I,Deraos G,Matsoukas J,Gravanis A,Mastorodemos V,Plaitakis A,Sharpe A,Boumpas D,Verginis P
Wed Feb 01 00:00:00 UTC 2012
Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.
Journal of proteome research
Lamour SD,Choi BS,Keun HC,Müller I,Saric J
Fri Aug 03 00:00:00 UTC 2012
Maturation of morphology, phenotype and functions of murine bone marrow-derived dendritic cells (DCs) induced by polysaccharide Kureha (PSK).
Human vaccines & immunotherapeutics
Tan Y,Meng Y,Wang Z,Shan F,Wang Q,Zhang N
214-14 was used in Cell Culture to indicate that PSK could markedly promote maturation of DCs and this adjuvant-like activity may have potential therapeutic value in vaccine preparation.
Sat Dec 01 00:00:00 UTC 2012
Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice.
Evidence-based complementary and alternative medicine : eCAM
Jin X,Uchiyama M,Zhang Q,Hirai T,Niimi M
Thu Aug 23 00:00:00 UTC 2012
Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis.
Theranostics
Yang M,Meng J,Cheng X,Lei J,Guo H,Zhang W,Kong H,Xu H
Tue Oct 02 00:00:00 UTC 2012
Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury.
Cell death & disease
Ishii H,Jin X,Ueno M,Tanabe S,Kubo T,Serada S,Naka T,Yamashita T
Thu Aug 09 00:00:00 UTC 2012
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
PloS one
Caserta S,Nausch N,Sawtell A,Drummond R,Barr T,Macdonald AS,Mutapi F,Zamoyska R
Thu Aug 23 00:00:00 UTC 2012
Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector.
PloS one
Williams BJ,Bhatia S,Adams LK,Boling S,Carroll JL,Li XL,Rogers DL,Korokhov N,Kovesdi I,Pereboev AV,Curiel DT,Mathis JM
Tue May 07 00:00:00 UTC 2013
Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).
PloS one
Bassity E,Clark TG
Mon Aug 20 00:00:00 UTC 2012
De novo DNA methylation is required to restrict T helper lineage plasticity.
The Journal of biological chemistry
Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD
Fri Jun 29 00:00:00 UTC 2012
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology
Gong D,Shi W,Yi SJ,Chen H,Groffen J,Heisterkamp N
Fri Jun 15 00:00:00 UTC 2012
Environmental conditioning in the control of macrophage thrombospondin-1 production.
Scientific reports
Fordham JB,Hua J,Morwood SR,Schewitz-Bowers LP,Copland DA,Dick AD,Nicholson LB
Sun Mar 17 00:00:00 UTC 2013
TGFβ signalling plays an important role in IL4-induced alternative activation of microglia.
Journal of neuroinflammation
Zhou X,Spittau B,Krieglstein K
Tue Sep 04 00:00:00 UTC 2012
Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.
PloS one
Zeng X,Wang T,Zhu C,Xing X,Ye Y,Lai X,Song B,Zeng Y
Mon Oct 22 00:00:00 UTC 2012
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry
Müller JR,Waldmann TA,Kruhlak MJ,Dubois S
Fri Nov 23 00:00:00 UTC 2012
Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma.
PloS one
Tian J,Ma J,Ma K,Ma B,Tang X,Baidoo SE,Tong J,Yan J,Lu L,Xu H,Wang S
Thu Mar 28 00:00:00 UTC 2013
Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis.
Journal of translational medicine
Li R,Zheng X,Popov I,Zhang X,Wang H,Suzuki M,Necochea-Campion RD,French PW,Chen D,Siu L,Koos D,Inman RD,Min WP
Tue Jan 31 00:00:00 UTC 2012
Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice.
Oncoimmunology
Herranz S,Través PG,Luque A,Hortelano S
Thu Nov 01 00:00:00 UTC 2012
Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation.
PloS one
Zhu W,Ventevogel MS,Knilans KJ,Anderson JE,Oldach LM,McKinnon KP,Hobbs MM,Sempowski GD,Duncan JA
Wed Nov 28 00:00:00 UTC 2012
p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.
The Journal of biological chemistry
Hu P,Nebreda AR,Liu Y,Carlesso N,Kaplan M,Kapur R
Fri Sep 28 00:00:00 UTC 2012
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
PloS one
Redmond WL,Triplett T,Floyd K,Weinberg AD
Tue Aug 21 00:00:00 UTC 2012
Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model.
PloS one
Li X,Li JJ,Yang JY,Wang DS,Zhao W,Song WJ,Li WM,Wang JF,Han W,Zhang ZC,Yu Y,Cao DY,Dou KF
Thu Feb 07 00:00:00 UTC 2013
Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells.
Journal of cardiothoracic surgery
Uchiyama M,Jin X,Zhang Q,Hirai T,Amano A,Bashuda H,Niimi M
Fri Mar 23 00:00:00 UTC 2012
The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein β (C/EBPβ).
The Journal of biological chemistry
Ye S,Xu H,Jin J,Yang M,Wang C,Yu Y,Cao X
Fri Aug 03 00:00:00 UTC 2012
Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.
Retrovirology
Negri DR,Rossi A,Blasi M,Michelini Z,Leone P,Chiantore MV,Baroncelli S,Perretta G,Cimarelli A,Klotman ME,Cara A
Wed Aug 22 00:00:00 UTC 2012
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.
PloS one
Vinay DS,Lee SJ,Kim CH,Oh HS,Kwon BS
Mon May 13 00:00:00 UTC 2013
Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).
The Journal of biological chemistry
Yang W,Lu Y,Xu Y,Xu L,Zheng W,Wu Y,Li L,Shen P
Fri Nov 23 00:00:00 UTC 2012
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.
PloS one
Saluja R,Delin I,Nilsson GP,Adner M
Wed Jan 16 00:00:00 UTC 2013
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Nature
Anthony RM,Kobayashi T,Wermeling F,Ravetch JV
Sun Jun 19 00:00:00 UTC 2011
The transcription factor STAT3 is required for T helper 2 cell development.
Immunity
Stritesky GL,Muthukrishnan R,Sehra S,Goswami R,Pham D,Travers J,Nguyen ET,Levy DE,Kaplan MH
Fri Jan 28 00:00:00 UTC 2011
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.
Immunity
Chae JJ,Cho YH,Lee GS,Cheng J,Liu PP,Feigenbaum L,Katz SI,Kastner DL
Fri May 27 00:00:00 UTC 2011
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
Fri May 27 00:00:00 UTC 2011
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Nature immunology
Beal AM,Ramos-Hernández N,Riling CR,Nowelsky EA,Oliver PM
Sun Nov 13 00:00:00 UTC 2011
Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms.
Blood
Balce DR,Li B,Allan ER,Rybicka JM,Krohn RM,Yates RM
Thu Oct 13 00:00:00 UTC 2011
Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity.
Blood
Xu X,Guo Z,Jiang X,Yao Y,Gao Q,Ding Y,Cao X
Thu Jan 27 00:00:00 UTC 2011
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality.
Blood
Sun Y,Varambally S,Maher CA,Cao Q,Chockley P,Toubai T,Malter C,Nieves E,Tawara I,Wang Y,Ward PA,Chinnaiyan A,Reddy P
Thu Jun 09 00:00:00 UTC 2011
Transcriptomic analyses of murine resolution-phase macrophages.
Blood
Stables MJ,Shah S,Camon EB,Lovering RC,Newson J,Bystrom J,Farrow S,Gilroy DW
Thu Dec 22 00:00:00 UTC 2011
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.
Blood
Kreisel D,Sugimoto S,Zhu J,Nava R,Li W,Okazaki M,Yamamoto S,Ibrahim M,Huang HJ,Toth KA,Ritter JH,Krupnick AS,Miller MJ,Gelman AE
Thu Dec 01 00:00:00 UTC 2011
p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.
Blood
Cudejko C,Wouters K,Fuentes L,Hannou SA,Paquet C,Bantubungi K,Bouchaert E,Vanhoutte J,Fleury S,Remy P,Tailleux A,Chinetti-Gbaguidi G,Dombrowicz D,Staels B,Paumelle R
Thu Sep 01 00:00:00 UTC 2011
Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.
The Journal of experimental medicine
Kurachi M,Kurachi J,Suenaga F,Tsukui T,Abe J,Ueha S,Tomura M,Sugihara K,Takamura S,Kakimi K,Matsushima K
Mon Aug 01 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
The Journal of experimental medicine
Lai D,Zhu J,Wang T,Hu-Li J,Terabe M,Berzofsky JA,Clayberger C,Krensky AM
Mon May 09 00:00:00 UTC 2011
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin.
Journal of biomedical science
Wei WC,Lin SY,Chen YJ,Wen CC,Huang CY,Palanisamy A,Yang NS,Sheu JH
Wed Dec 21 00:00:00 UTC 2011
Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines.
Journal of biomedical science
Wen CC,Chen HM,Chen SS,Huang LT,Chang WT,Wei WC,Chou LC,Arulselvan P,Wu JB,Kuo SC,Yang NS
Mon Jun 20 00:00:00 UTC 2011
Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy.
Diabetes
Bertin-Maghit S,Pang D,O'Sullivan B,Best S,Duggan E,Paul S,Thomas H,Kay TW,Harrison LC,Steptoe R,Thomas R
Sat Jan 01 00:00:00 UTC 2011
An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells.
Rheumatology (Oxford, England)
Ling GS,Cook HT,Botto M,Lau YL,Huang FP
Sat Oct 01 00:00:00 UTC 2011
The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Ramachandran IR,Song W,Lapteva N,Seethammagari M,Slawin KM,Spencer DM,Levitt JM
Fri Apr 01 00:00:00 UTC 2011
Suppressive effect of bacterial polysaccharides on BAFF system is responsible for their poor immunogenicity.
Journal of immunology (Baltimore, Md. : 1950)
Kanswal S,Katsenelson N,Allman W,Uslu K,Blake MS,Akkoyunlu M
Tue Feb 15 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 UTC 2011
Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.
Journal of immunology (Baltimore, Md. : 1950)
Koguchi Y,Gardell JL,Thauland TJ,Parker DC
Fri Jul 15 00:00:00 UTC 2011
Elf3 regulates allergic airway inflammation by controlling dendritic cell-driven T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kushwah R,Oliver JR,Wu J,Chang Z,Hu J
Tue Nov 01 00:00:00 UTC 2011
Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950)
Rafei M,Hardy MP,Williams P,Vanegas JR,Forner KA,Dulude G,Labrecque N,Galipeau J,Perreault C
Thu Sep 15 00:00:00 UTC 2011
Recruitment of dendritic cells is responsible for intestinal epithelial damage in the pathogenesis of necrotizing enterocolitis by Cronobacter sakazakii.
Journal of immunology (Baltimore, Md. : 1950)
Emami CN,Mittal R,Wang L,Ford HR,Prasadarao NV
Wed Jun 15 00:00:00 UTC 2011
Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa R,Yoshida H,Asakawa M,Tamiya T,Inoue N,Morita R,Inoue H,Nakao A,Yoshimura A
Tue Nov 01 00:00:00 UTC 2011
Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Liu F,Jia H,Zhang Q,Yin L,Liu W,Li H,Yu B,Wu J
Mon Aug 15 00:00:00 UTC 2011
MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Min HS,Lee YJ,Jeon YK,Kim EJ,Kang BH,Jung KC,Chang CH,Park SH
Sun May 15 00:00:00 UTC 2011
Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
Journal of immunology (Baltimore, Md. : 1950)
Cho H,Choi HJ,Xu H,Felio K,Wang CR
Sat Jan 01 00:00:00 UTC 2011
Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.
Journal of immunology (Baltimore, Md. : 1950)
Eccleston J,Yan C,Yuan K,Alt FW,Selsing E
Tue Feb 15 00:00:00 UTC 2011
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.
Journal of immunology (Baltimore, Md. : 1950)
Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q
Sat Oct 15 00:00:00 UTC 2011
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Molinero LL,Miller ML,Evaristo C,Alegre ML
Fri Apr 15 00:00:00 UTC 2011
SOCS3 deletion in B cells alters cytokine responses and germinal center output.
Journal of immunology (Baltimore, Md. : 1950)
Jones SA,White CA,Robb L,Alexander WS,Tarlinton DM
Thu Dec 15 00:00:00 UTC 2011
Sensitivity and resistance to regulation by IL-4 during Th17 maturation.
Journal of immunology (Baltimore, Md. : 1950)
Cooney LA,Towery K,Endres J,Fox DA
Tue Nov 01 00:00:00 UTC 2011
A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
Journal of immunology (Baltimore, Md. : 1950)
Fiancette R,Rouaud P,Vincent-Fabert C,Laffleur B,Magnone V,Cogné M,Denizot Y
Thu Dec 01 00:00:00 UTC 2011
Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Tong J,Wu WN,Kong X,Wu PF,Tian L,Du W,Fang M,Zheng F,Chen JG,Tan Z,Gong F
Tue Mar 15 00:00:00 UTC 2011
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.
Journal of immunology (Baltimore, Md. : 1950)
Galitovskiy V,Qian J,Chernyavsky AI,Marchenko S,Gindi V,Edwards RA,Grando SA
Thu Sep 01 00:00:00 UTC 2011
Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Yu S,Zhao J,Cantorna MT
Tue Nov 01 00:00:00 UTC 2011
Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response.
Journal of immunology (Baltimore, Md. : 1950)
King RG,Herrin BR,Justement LB
Sat Oct 01 00:00:00 UTC 2011
Thymic stromal lymphopoietin is produced by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ
Mon Aug 01 00:00:00 UTC 2011
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Xu W,Xiong S
Mon Aug 15 00:00:00 UTC 2011
Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells.
Journal of immunology (Baltimore, Md. : 1950)
Aust JG,Gays F,Hussain F,Butcher GW,Kist R,Peters H,Brooks CG
Tue Feb 15 00:00:00 UTC 2011
MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Zhang F,Chen F,Liu D,Zheng Y,Zhang Y,Dong C,Su B
Sun May 15 00:00:00 UTC 2011
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sehra S,Yao W,Nguyen ET,Ahyi AN,Tuana FM,Ahlfeld SK,Snider P,Tepper RS,Petrache I,Conway SJ,Kaplan MH
Fri Apr 15 00:00:00 UTC 2011
B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.
Journal of immunology (Baltimore, Md. : 1950)
Jiang C,Loo WM,Greenley EJ,Tung KS,Erickson LD
Wed Jun 01 00:00:00 UTC 2011
Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication.
Veterinary research
Marshall ES,Elshekiha HM,Hakimi MA,Flynn RJ
Mon Jun 27 00:00:00 UTC 2011
Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting.
The Journal of biological chemistry
Amano Y,Yamashita Y,Kojima K,Yoshino K,Tanaka N,Sugamura K,Takeshita T
Fri Apr 29 00:00:00 UTC 2011
In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.
International journal of nanomedicine
Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q
Tue Mar 27 00:00:00 UTC 2012
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model.
PloS one
Yang C,Kim SH,Bianco NR,Robbins PD
Tue Dec 27 00:00:00 UTC 2011
Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma.
The Journal of biological chemistry
Goto Y,Ogawa K,Hattori A,Tsujimoto M
Fri Jun 17 00:00:00 UTC 2011
TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates.
PloS one
L'Abbate C,Cipriano I,Pérez-Hurtado EC,Leão SC,Carneiro CR,Machado J
Wed Nov 02 00:00:00 UTC 2011
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo.
Nature communications
Nojima T,Haniuda K,Moutai T,Matsudaira M,Mizokawa S,Shiratori I,Azuma T,Kitamura D
Tue Sep 06 00:00:00 UTC 2011
Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs.
BMC immunology
Wang Y,Xiong X,Wu D,Wang X,Wen B
Sat Sep 03 00:00:00 UTC 2011
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).
The Journal of biological chemistry
Corcoran K,Jabbour M,Bhagwandin C,Deymier MJ,Theisen DL,Lybarger L
Fri Oct 28 00:00:00 UTC 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 UTC 2011
PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation.
The Journal of biological chemistry
Mehrotra P,Riley JP,Patel R,Li F,Voss L,Goenka S
Fri Jan 21 00:00:00 UTC 2011
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.
PloS one
Coler RN,Bertholet S,Moutaftsi M,Guderian JA,Windish HP,Baldwin SL,Laughlin EM,Duthie MS,Fox CB,Carter D,Friede M,Vedvick TS,Reed SG
Wed Jan 26 00:00:00 UTC 2011
Species difference of CD137 ligand signaling in human and murine monocytes.
PloS one
Tang Q,Jiang D,Shao Z,Martínez Gómez JM,Schwarz H
Fri Jan 14 00:00:00 UTC 2011
Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.
PloS one
Grespi F,Ottina E,Yannoutsos N,Geley S,Villunger A
Mon Mar 21 00:00:00 UTC 2011
Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells.
PloS one
Wang L,Lin J,Zhou Z,Huo R,Shen B,Sun Y,Li N
Fri May 18 00:00:00 UTC 2012
The interaction between different types of activated RAW 264.7 cells and macrophage inflammatory protein-1 alpha.
Radiation oncology (London, England)
He Z,Zhang H,Yang C,Zhou Y,Zhou Y,Han G,Xia L,Ouyang W,Zhou F,Zhou Y,Xie C
Fri Jul 22 00:00:00 UTC 2011
Induction of B-cell lymphoma by UVB radiation in p53 haploinsufficient mice.
BMC cancer
Puebla-Osorio N,Miyahara Y,Coimbatore S,Limón-Flores AY,Kazimi N,Ullrich SE,Zhu C
Wed Jan 26 00:00:00 UTC 2011
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Nature communications
Sekiya T,Kashiwagi I,Inoue N,Morita R,Hori S,Waldmann H,Rudensky AY,Ichinose H,Metzger D,Chambon P,Yoshimura A
Fri Jul 22 00:00:00 UTC 2011
Regulation of T cell priming by lymphoid stroma.
PloS one
Khan O,Headley M,Gerard A,Wei W,Liu L,Krummel MF
Mon Mar 26 00:00:00 UTC 2012
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
Thu Sep 29 00:00:00 UTC 2011
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 UTC 2011
Mice with different susceptibility to Japanese encephalitis virus infection show selective neutralizing antibody response and myeloid cell infectivity.
PloS one
Wang K,Deubel V
Mon Jan 30 00:00:00 UTC 2012
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
Mon Oct 17 00:00:00 UTC 2011
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes.
Cell death & disease
Dunkle A,Dzhagalov I,He YW
Thu Oct 06 00:00:00 UTC 2011
Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis.
International journal of biological sciences
Liu C,Lin J,Zhao L,Yang Y,Gao F,Li B,Cui J,Cai J
Mon Feb 14 00:00:00 UTC 2011
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
PloS one
Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T
Mon Mar 26 00:00:00 UTC 2012
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature
Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H
Thu Apr 29 00:00:00 UTC 2010
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.
Cell
Cheong C,Matos I,Choi JH,Dandamudi DB,Shrestha E,Longhi MP,Jeffrey KL,Anthony RM,Kluger C,Nchinda G,Koh H,Rodriguez A,Idoyaga J,Pack M,Velinzon K,Park CG,Steinman RM
Fri Oct 29 00:00:00 UTC 2010
Single-gene transgenic mouse strains for reprogramming adult somatic cells.
Nature methods
Carey BW,Markoulaki S,Beard C,Hanna J,Jaenisch R
Fri Jan 01 00:00:00 UTC 2010
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 UTC 2010
The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.
Immunity
Carotta S,Dakic A,D'Amico A,Pang SH,Greig KT,Nutt SL,Wu L
Fri May 28 00:00:00 UTC 2010
MicroRNAs prevent the generation of autoreactive antibodies.
Immunity
Belver L,de Yébenes VG,Ramiro AR
Wed Nov 24 00:00:00 UTC 2010
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
Immunity
Tavares RM,Turer EE,Liu CL,Advincula R,Scapini P,Rhee L,Barrera J,Lowell CA,Utz PJ,Malynn BA,Ma A
Fri Aug 27 00:00:00 UTC 2010
Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation.
Blood
Divito SJ,Wang Z,Shufesky WJ,Liu Q,Tkacheva OA,Montecalvo A,Erdos G,Larregina AT,Morelli AE
Thu Oct 14 00:00:00 UTC 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 UTC 2010
Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation.
Blood
Milner JD,Orekov T,Ward JM,Cheng L,Torres-Velez F,Junttila I,Sun G,Buller M,Morris SC,Finkelman FD,Paul WE
Thu Oct 07 00:00:00 UTC 2010
The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.
Cellular & molecular immunology
Ma F,Zhang J,Zhang J,Zhang C
Wed Sep 01 00:00:00 UTC 2010
Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells.
Cellular & molecular immunology
Suzuki T,Oo Chang M,Kitajima M,Takaku H
Mon Nov 01 00:00:00 UTC 2010
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
The Journal of experimental medicine
Scapini P,Hu Y,Chu CL,Migone TS,Defranco AL,Cassatella MA,Lowell CA
Mon Aug 02 00:00:00 UTC 2010
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.
The Journal of experimental medicine
Wang YH,Voo KS,Liu B,Chen CY,Uygungil B,Spoede W,Bernstein JA,Huston DP,Liu YJ
Mon Oct 25 00:00:00 UTC 2010
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
The Journal of experimental medicine
Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H
Mon Nov 22 00:00:00 UTC 2010
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
The Journal of experimental medicine
Westerberg LS,Meelu P,Baptista M,Eston MA,Adamovich DA,Cotta-de-Almeida V,Seed B,Rosen MK,Vandenberghe P,Thrasher AJ,Klein C,Alt FW,Snapper SB
Mon Jun 07 00:00:00 UTC 2010
CD11c depletion severely disrupts Th2 induction and development in vivo.
The Journal of experimental medicine
Phythian-Adams AT,Cook PC,Lundie RJ,Jones LH,Smith KA,Barr TA,Hochweller K,Anderton SM,Hämmerling GJ,Maizels RM,MacDonald AS
Mon Sep 27 00:00:00 UTC 2010
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Leukemia
Sanchez-Aguilera A,Rattmann I,Drew DZ,Müller LU,Summey V,Lucas DM,Byrd JC,Croce CM,Gu Y,Cancelas JA,Johnston P,Moritz T,Williams DA
Fri Jan 01 00:00:00 UTC 2010
Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.
Proceedings of the National Academy of Sciences of the United States of America
Duchez S,Amin R,Cogné N,Delpy L,Sirac C,Pascal V,Corthésy B,Cogné M
Tue Feb 16 00:00:00 UTC 2010
Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma.
Proceedings of the National Academy of Sciences of the United States of America
Nemeth K,Keane-Myers A,Brown JM,Metcalfe DD,Gorham JD,Bundoc VG,Hodges MG,Jelinek I,Madala S,Karpati S,Mezey E
Tue Mar 23 00:00:00 UTC 2010
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Mortensen M,Ferguson DJ,Edelmann M,Kessler B,Morten KJ,Komatsu M,Simon AK
Tue Jan 12 00:00:00 UTC 2010
PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions.
Mucosal immunology
Akbari O,Stock P,Singh AK,Lombardi V,Lee WL,Freeman GJ,Sharpe AH,Umetsu DT,Dekruyff RH
Fri Jan 01 00:00:00 UTC 2010
IPS-1 is essential for the control of West Nile virus infection and immunity.
PLoS pathogens
Suthar MS,Ma DY,Thomas S,Lund JM,Zhang N,Daffis S,Rudensky AY,Bevan MJ,Clark EA,Kaja MK,Diamond MS,Gale M
Fri Feb 05 00:00:00 UTC 2010
RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis.
Arthritis research & therapy
Zheng X,Suzuki M,Zhang X,Ichim TE,Zhu F,Ling H,Shunnar A,Wang MH,Garcia B,Inman RD,Min WP
Fri Aug 13 00:00:00 UTC 2010
The interactions of multiple cytokines control NK cell maturation.
Journal of immunology (Baltimore, Md. : 1950)
Brady J,Carotta S,Thong RP,Chan CJ,Hayakawa Y,Smyth MJ,Nutt SL
Wed Dec 01 00:00:00 UTC 2010
A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Balsley MA,Malesevic M,Stemmy EJ,Gigley J,Jurjus RA,Herzog D,Bukrinsky MI,Fischer G,Constant SL
Wed Dec 15 00:00:00 UTC 2010
Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.
Journal of immunology (Baltimore, Md. : 1950)
Hart R,Greaves DR
Wed Sep 15 00:00:00 UTC 2010
Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ng RL,Bisley JL,Gorman S,Norval M,Hart PH
Wed Dec 15 00:00:00 UTC 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 UTC 2010
In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.
Journal of immunology (Baltimore, Md. : 1950)
Bébin AG,Carrion C,Marquet M,Cogné N,Lecardeur S,Cogné M,Pinaud E
Thu Apr 01 00:00:00 UTC 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
Sun Aug 15 00:00:00 UTC 2010
Expression of cellular FLIP by B cells is required for their participation in an immune response.
Journal of immunology (Baltimore, Md. : 1950)
Coffey F,Manser T
Sat May 01 00:00:00 UTC 2010
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Iype T,Sankarshanan M,Mauldin IS,Mullins DW,Lorenz U
Mon Nov 15 00:00:00 UTC 2010
Intralesional delivery of dendritic cells engineered to express T-bet promotes protective type 1 immunity and the normalization of the tumor microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
Qu Y,Chen L,Pardee AD,Taylor JL,Wesa AK,Storkus WJ
Wed Sep 01 00:00:00 UTC 2010
MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα.
Journal of immunology (Baltimore, Md. : 1950)
Liu X,Zhan Z,Xu L,Ma F,Li D,Guo Z,Li N,Cao X
Wed Dec 15 00:00:00 UTC 2010
Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.
Journal of immunology (Baltimore, Md. : 1950)
Li F,Yan Y,Pieretti J,Feldman DA,Eckhardt LA
Mon Nov 15 00:00:00 UTC 2010
IL-33 exacerbates eosinophil-mediated airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Stolarski B,Kurowska-Stolarska M,Kewin P,Xu D,Liew FY
Wed Sep 15 00:00:00 UTC 2010
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Iwakura Y,Yoshikai Y
Wed Dec 15 00:00:00 UTC 2010
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
Journal of immunology (Baltimore, Md. : 1950)
Bolduc A,Long E,Stapler D,Cascalho M,Tsubata T,Koni PA,Shimoda M
Thu Jul 01 00:00:00 UTC 2010
Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.
Journal of immunology (Baltimore, Md. : 1950)
Al-Alwan M,Hou S,Zhang TT,Makondo K,Marshall AJ
Tue Jun 15 00:00:00 UTC 2010
Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Torres D,Dieudonné A,Ryffel B,Vilain E,Si-Tahar M,Pichavant M,Lassalle P,Trottein F,Gosset P
Thu Jul 01 00:00:00 UTC 2010
Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Journal of immunology (Baltimore, Md. : 1950)
Kemp KL,Levin SD,Bryce PJ,Stein PL
Thu Apr 15 00:00:00 UTC 2010
Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Nagarkar DR,Bowman ER,Schneider D,Wang Q,Shim J,Zhao Y,Linn MJ,McHenry CL,Gosangi B,Bentley JK,Tsai WC,Sajjan US,Lukacs NW,Hershenson MB
Sun Aug 15 00:00:00 UTC 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 UTC 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 UTC 2010
Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Zheng X,Suzuki M,Ichim TE,Zhang X,Sun H,Zhu F,Shunnar A,Garcia B,Inman RD,Min W
Tue Jun 01 00:00:00 UTC 2010
Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Mai A,Sun J
Fri Jan 01 00:00:00 UTC 2010
PDCA expression by B lymphocytes reveals important functional attributes.
Journal of immunology (Baltimore, Md. : 1950)
Vinay DS,Kim CH,Chang KH,Kwon BS
Fri Jan 15 00:00:00 UTC 2010
The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression.
Journal of immunology (Baltimore, Md. : 1950)
Zhang TT,Al-Alwan M,Marshall AJ
Fri Jan 01 00:00:00 UTC 2010
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Prados JC,Través PG,Cuenca J,Rico D,Aragonés J,Martín-Sanz P,Cascante M,Boscá L
Thu Jul 01 00:00:00 UTC 2010
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.
Journal of immunology (Baltimore, Md. : 1950)
Turnis ME,Song XT,Bear A,Foster AE,Gottschalk S,Brenner MK,Chen SY,Rooney CM
Fri Oct 01 00:00:00 UTC 2010
Activation-induced cytidine deaminase splice variants are defective because of the lack of structural support for the catalytic site.
Journal of immunology (Baltimore, Md. : 1950)
van Maldegem F,Jibodh RA,van Dijk R,Bende RJ,van Noesel CJ
Mon Mar 01 00:00:00 UTC 2010
Immune dysregulation by the rheumatoid arthritis shared epitope.
Journal of immunology (Baltimore, Md. : 1950)
De Almeida DE,Ling S,Pi X,Hartmann-Scruggs AM,Pumpens P,Holoshitz J
Sun Aug 01 00:00:00 UTC 2010
Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.
Journal of immunology (Baltimore, Md. : 1950)
Takimoto T,Wakabayashi Y,Sekiya T,Inoue N,Morita R,Ichiyama K,Takahashi R,Asakawa M,Muto G,Mori T,Hasegawa E,Saika S,Hara T,Nomura M,Yoshimura A
Thu Jul 15 00:00:00 UTC 2010
Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Elsheikh A,Lavergne SN,Castrejon JL,Farrell J,Wang H,Sathish J,Pichler WJ,Park BK,Naisbitt DJ
Wed Dec 01 00:00:00 UTC 2010
Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.
PloS one
Domingues HS,Mues M,Lassmann H,Wekerle H,Krishnamoorthy G
Mon Nov 29 00:00:00 UTC 2010
Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock.
PloS one
Zhong J,Yang P,Muta K,Dong R,Marrero M,Gong F,Wang CY
Tue Mar 09 00:00:00 UTC 2010
cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation.
PloS one
Albert E,Walker J,Thiesen A,Churchill T,Madsen K
Wed Oct 27 00:00:00 UTC 2010
An NF-kappaB-dependent role for JunB in the induction of proinflammatory cytokines in LPS-activated bone marrow-derived dendritic cells.
PloS one
Gomard T,Michaud HA,Tempé D,Thiolon K,Pelegrin M,Piechaczyk M
Mon Mar 08 00:00:00 UTC 2010
Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.
The Journal of biological chemistry
Denda-Nagai K,Aida S,Saba K,Suzuki K,Moriyama S,Oo-Puthinan S,Tsuiji M,Morikawa A,Kumamoto Y,Sugiura D,Kudo A,Akimoto Y,Kawakami H,Bovin NV,Irimura T
Fri Jun 18 00:00:00 UTC 2010
Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.
PLoS neglected tropical diseases
Zhang S,Kim CC,Batra S,McKerrow JH,Loke P
Tue Mar 30 00:00:00 UTC 2010
Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.
The Journal of biological chemistry
An L,Wang Y,Liu Y,Yang X,Liu C,Hu Z,He W,Song W,Hang H
Fri Nov 12 00:00:00 UTC 2010
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
Journal of neuroinflammation
Dohi K,Ohtaki H,Nakamachi T,Yofu S,Satoh K,Miyamoto K,Song D,Tsunawaki S,Shioda S,Aruga T
Mon Jul 26 00:00:00 UTC 2010
miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy.
Journal of translational medicine
Sasaki K,Kohanbash G,Hoji A,Ueda R,McDonald HA,Reinhart TA,Martinson J,Lotze MT,Marincola FM,Wang E,Fujita M,Okada H
Thu Feb 18 00:00:00 UTC 2010
Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity.
PloS one
Renaudet O,Dasgupta G,Bettahi I,Shi A,Nesburn AB,Dumy P,BenMohamed L
Mon Jun 21 00:00:00 UTC 2010
Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection.
mBio
Zhou H,Zhao J,Perlman S
Tue Oct 19 00:00:00 UTC 2010
In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine.
BMC immunology
Vilekar P,Awasthi V,Lagisetty P,King C,Shankar N,Awasthi S
Fri Dec 10 00:00:00 UTC 2010
Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes.
Autoimmune diseases
Linkes S,Fry C,Quinn A
Wed Sep 29 00:00:00 UTC 2010
The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent.
BMC immunology
He Y,Li J,Zhuang W,Yin L,Chen C,Li J,Chi F,Bai Y,Chen XP
Thu Jun 10 00:00:00 UTC 2010
Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.
Cell death & disease
Karlberg M,Ekoff M,Labi V,Strasser A,Huang D,Nilsson G
Thu May 13 00:00:00 UTC 2010
Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123.
The Journal of biological chemistry
Takekoshi T,Tada Y,Watanabe T,Sugaya M,Hoashi T,Komine M,Kawashima T,Shimizu T,Hau CS,Asahina A,Yokomizo T,Sato S,Tamaki K
Fri Oct 08 00:00:00 UTC 2010
The AP-1 transcription factor Batf controls T(H)17 differentiation.
Nature
Schraml BU,Hildner K,Ise W,Lee WL,Smith WA,Solomon B,Sahota G,Sim J,Mukasa R,Cemerski S,Hatton RD,Stormo GD,Weaver CT,Russell JH,Murphy TL,Murphy KM
Thu Jul 16 00:00:00 UTC 2009
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
Immunity
Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD
Fri Jun 19 00:00:00 UTC 2009
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Immunity
Meng G,Zhang F,Fuss I,Kitani A,Strober W
Fri Jun 19 00:00:00 UTC 2009
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
Cancer cell
DeNardo DG,Barreto JB,Andreu P,Vasquez L,Tawfik D,Kolhatkar N,Coussens LM
Tue Aug 04 00:00:00 UTC 2009
Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.
Blood
Creusot RJ,Yaghoubi SS,Chang P,Chia J,Contag CH,Gambhir SS,Fathman CG
Thu Jun 25 00:00:00 UTC 2009
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Blood
Caruso R,Stolfi C,Sarra M,Rizzo A,Fantini MC,Pallone F,MacDonald TT,Monteleone G
Thu Apr 09 00:00:00 UTC 2009
A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation.
Blood
Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP
Thu Mar 19 00:00:00 UTC 2009
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
The Journal of experimental medicine
Nolting J,Daniel C,Reuter S,Stuelten C,Li P,Sucov H,Kim BG,Letterio JJ,Kretschmer K,Kim HJ,von Boehmer H
Mon Sep 28 00:00:00 UTC 2009
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.
The Journal of experimental medicine
Herbert DR,Yang JQ,Hogan SP,Groschwitz K,Khodoun M,Munitz A,Orekov T,Perkins C,Wang Q,Brombacher F,Urban JF,Rothenberg ME,Finkelman FD
Mon Dec 21 00:00:00 UTC 2009
Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals.
The Journal of experimental medicine
Benson MJ,Elgueta R,Schpero W,Molloy M,Zhang W,Usherwood E,Noelle RJ
Mon Aug 31 00:00:00 UTC 2009
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.
The Journal of experimental medicine
Maldonado RA,Soriano MA,Perdomo LC,Sigrist K,Irvine DJ,Decker T,Glimcher LH
Mon Apr 13 00:00:00 UTC 2009
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
The Journal of experimental medicine
Tachdjian R,Mathias C,Al Khatib S,Bryce PJ,Kim HS,Blaeser F,O'Connor BD,Rzymkiewicz D,Chen A,Holtzman MJ,Hershey GK,Garn H,Harb H,Renz H,Oettgen HC,Chatila TA
Mon Sep 28 00:00:00 UTC 2009
Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.
The Journal of experimental medicine
Gabrysová L,Nicolson KS,Streeter HB,Verhagen J,Sabatos-Peyton CA,Morgan DJ,Wraith DC
Mon Aug 03 00:00:00 UTC 2009
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
The Journal of experimental medicine
Felio K,Nguyen H,Dascher CC,Choi HJ,Li S,Zimmer MI,Colmone A,Moody DB,Brenner MB,Wang CR
Mon Oct 26 00:00:00 UTC 2009
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine
Takatori H,Kanno Y,Watford WT,Tato CM,Weiss G,Ivanov II,Littman DR,O'Shea JJ
Fri Jan 16 00:00:00 UTC 2009
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.
The EMBO journal
Pelegrin P,Surprenant A
Wed Jul 22 00:00:00 UTC 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 UTC 2009
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Proceedings of the National Academy of Sciences of the United States of America
Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH
Tue Oct 06 00:00:00 UTC 2009
pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.
Proceedings of the National Academy of Sciences of the United States of America
Shimizu Y,Meunier L,Hendershot LM
Tue Oct 06 00:00:00 UTC 2009
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Komatsu N,Mariotti-Ferrandiz ME,Wang Y,Malissen B,Waldmann H,Hori S
Tue Feb 10 00:00:00 UTC 2009
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.
Proceedings of the National Academy of Sciences of the United States of America
Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M
Tue Oct 20 00:00:00 UTC 2009
Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
PLoS pathogens
Daffis S,Suthar MS,Szretter KJ,Gale M,Diamond MS
Thu Oct 01 00:00:00 UTC 2009
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.
Journal of leukocyte biology
Choi BS,Martinez-Falero IC,Corset C,Munder M,Modolell M,Müller I,Kropf P
Sun Feb 01 00:00:00 UTC 2009
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts.
Journal of immunology (Baltimore, Md. : 1950)
Nurieva R,Yang XO,Chung Y,Dong C
Sun Mar 01 00:00:00 UTC 2009
Sustained and NK/CD4+ T cell-dependent efficient prevention of lung metastasis induced by dendritic cells harboring recombinant Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Komaru A,Ueda Y,Furuya A,Tanaka S,Yoshida K,Kato T,Kinoh H,Harada Y,Suzuki H,Inoue M,Hasegawa M,Ichikawa T,Yonemitsu Y
Thu Oct 01 00:00:00 UTC 2009
Ikaros is a regulator of Il10 expression in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Umetsu SE,Winandy S
Sun Nov 01 00:00:00 UTC 2009
Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1.
Journal of immunology (Baltimore, Md. : 1950)
Aoki K,Sato N,Yamaguchi A,Kaminuma O,Hosozawa T,Miyatake S
Mon Jun 15 00:00:00 UTC 2009
PU.1 regulates TCR expression by modulating GATA-3 activity.
Journal of immunology (Baltimore, Md. : 1950)
Chang HC,Han L,Jabeen R,Carotta S,Nutt SL,Kaplan MH
Thu Oct 15 00:00:00 UTC 2009
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K
Mon Jun 15 00:00:00 UTC 2009
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA
Wed Apr 15 00:00:00 UTC 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
Tue Dec 15 00:00:00 UTC 2009
Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A.
Journal of immunology (Baltimore, Md. : 1950)
Hauser J,Verma-Gaur J,Wallenius A,Grundström T
Wed Jul 15 00:00:00 UTC 2009
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
Journal of immunology (Baltimore, Md. : 1950)
Gondek DC,Roan NR,Starnbach MN
Wed Jul 15 00:00:00 UTC 2009
Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950)
Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK
Sat Aug 15 00:00:00 UTC 2009
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.
Journal of immunology (Baltimore, Md. : 1950)
Sun Y,Chin YE,Weisiger E,Malter C,Tawara I,Toubai T,Gatza E,Mascagni P,Dinarello CA,Reddy P
Fri May 15 00:00:00 UTC 2009
Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones TG,Hallgren J,Humbles A,Burwell T,Finkelman FD,Alcaide P,Austen KF,Gurish MF
Thu Oct 15 00:00:00 UTC 2009
Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion.
Journal of immunology (Baltimore, Md. : 1950)
Turner MS,Kane LP,Morel PA
Thu Oct 15 00:00:00 UTC 2009
Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Shurin GV,Tourkova IL,Kaneno R,Shurin MR
Wed Jul 01 00:00:00 UTC 2009
Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM.
Journal of immunology (Baltimore, Md. : 1950)
Kamala T,Nanda NK
Wed Apr 15 00:00:00 UTC 2009
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Enzler T,Chang X,Facchinetti V,Melino G,Karin M,Su B,Gallagher E
Tue Sep 15 00:00:00 UTC 2009
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Chang X,Facchinetti V,Zhuang Y,Su B
Sun Mar 15 00:00:00 UTC 2009
Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Morris SC,Heidorn SM,Herbert DR,Perkins C,Hildeman DA,Khodoun MV,Finkelman FD
Sun Feb 01 00:00:00 UTC 2009
Cutting edge: Ikaros is a regulator of Th2 cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Quirion MR,Gregory GD,Umetsu SE,Winandy S,Brown MA
Thu Jan 15 00:00:00 UTC 2009
Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V
Mon Jun 01 00:00:00 UTC 2009
Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.
Journal of immunology (Baltimore, Md. : 1950)
Eccleston J,Schrader CE,Yuan K,Stavnezer J,Selsing E
Wed Jul 15 00:00:00 UTC 2009
Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.
Journal of immunology (Baltimore, Md. : 1950)
Jabbour M,Campbell EM,Fares H,Lybarger L
Sun Nov 15 00:00:00 UTC 2009
The expression and function of the NKRP1 receptor family in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950)
Aust JG,Gays F,Mickiewicz KM,Buchanan E,Brooks CG
Wed Jul 01 00:00:00 UTC 2009
Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.
Journal of immunology (Baltimore, Md. : 1950)
Vincent-Fabert C,Truffinet V,Fiancette R,Cogné N,Cogné M,Denizot Y
Mon Jun 01 00:00:00 UTC 2009
The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JM,Ross WG,Agbai ON,Frazier R,Figler RA,Rieger J,Linden J,Ernst PB
Wed Apr 15 00:00:00 UTC 2009
Helios deficiency has minimal impact on T cell development and function.
Journal of immunology (Baltimore, Md. : 1950)
Cai Q,Dierich A,Oulad-Abdelghani M,Chan S,Kastner P
Sat Aug 15 00:00:00 UTC 2009
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Journal of immunology (Baltimore, Md. : 1950)
Mielke LA,Elkins KL,Wei L,Starr R,Tsichlis PN,O'Shea JJ,Watford WT
Tue Dec 15 00:00:00 UTC 2009
Complete elimination of established neuroblastoma by synergistic action of gamma-irradiation and DCs treated with rSeV expressing interferon-beta gene.
Gene therapy
Tatsuta K,Tanaka S,Tajiri T,Shibata S,Komaru A,Ueda Y,Inoue M,Hasegawa M,Suita S,Sueishi K,Taguchi T,Yonemitsu Y
Sun Feb 01 00:00:00 UTC 2009
Dendritic cells transduced with lentiviral-mediated RelB-specific ShRNAs inhibit the development of experimental autoimmune myasthenia gravis.
Molecular immunology
Zhang Y,Yang H,Xiao B,Wu M,Zhou W,Li J,Li G,Christadoss P
Sun Feb 01 00:00:00 UTC 2009
Cytokine-based log-scale expansion of functional murine dendritic cells.
PloS one
Harada Y,Ueda Y,Kinoh H,Komaru A,Fuji-Ogawa T,Furuya A,Iida A,Hasegawa M,Ichikawa T,Yonemitsu Y
Tue Aug 18 00:00:00 UTC 2009
Transplacental passage of interleukins 4 and 13?
PloS one
Lim RH,Kobzik L
Mon Apr 27 00:00:00 UTC 2009
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Immunity
Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C
Fri Nov 14 00:00:00 UTC 2008
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
Immunity
Meylan F,Davidson TS,Kahle E,Kinder M,Acharya K,Jankovic D,Bundoc V,Hodges M,Shevach EM,Keane-Myers A,Wang EC,Siegel RM
Fri Jul 18 00:00:00 UTC 2008
A two-step process for thymic regulatory T cell development.
Immunity
Lio CW,Hsieh CS
Tue Jan 01 00:00:00 UTC 2008
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation
De Santo C,Salio M,Masri SH,Lee LY,Dong T,Speak AO,Porubsky S,Booth S,Veerapen N,Besra GS,Gröne HJ,Platt FM,Zambon M,Cerundolo V
Mon Dec 01 00:00:00 UTC 2008
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.
The Journal of experimental medicine
Chong MM,Rasmussen JP,Rudensky AY,Littman DR
Mon Sep 01 00:00:00 UTC 2008
Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Himoudi N,Nabarro S,Buddle J,Eddaoudi A,Thrasher AJ,Anderson J
Sat Nov 01 00:00:00 UTC 2008
Regulation of alternative macrophage activation by galectin-3.
Journal of immunology (Baltimore, Md. : 1950)
MacKinnon AC,Farnworth SL,Hodkinson PS,Henderson NC,Atkinson KM,Leffler H,Nilsson UJ,Haslett C,Forbes SJ,Sethi T
Fri Feb 15 00:00:00 UTC 2008
Intrarectal vaccination with recombinant vaccinia virus expressing carcinoembronic antigen induces mucosal and systemic immunity and prevents progression of colorectal cancer.
Journal of immunology (Baltimore, Md. : 1950)
Kim-Schulze S,Kim HS,Wainstein A,Kim DW,Yang WC,Moroziewicz D,Mong PY,Bereta M,Taback B,Wang Q,Kaufman HL
Mon Dec 01 00:00:00 UTC 2008
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.
Journal of immunology (Baltimore, Md. : 1950)
Kamimura D,Bevan MJ
Wed Oct 15 00:00:00 UTC 2008
Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Saito K,Torii M,Ma N,Tsuchiya T,Wang L,Hori T,Nagakubo D,Nitta N,Kanegasaki S,Hieshima K,Yoshie O,Gabazza EC,Katayama N,Shiku H,Kuribayashi K,Kato T
Sat Nov 15 00:00:00 UTC 2008
Transcription factor Gfi1 restricts B cell-mediated autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Rathinam C,Lassmann H,Mengel M,Klein C
Sat Nov 01 00:00:00 UTC 2008
TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Radhakrishnan S,Arneson LN,Upshaw JL,Howe CL,Felts SJ,Colonna M,Leibson PJ,Rodriguez M,Pease LR
Mon Dec 01 00:00:00 UTC 2008
IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu E,Kawahara K,Kajizono M,Sawada M,Nakayama H
Sat Nov 01 00:00:00 UTC 2008
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Kurowska-Stolarska M,Kewin P,Murphy G,Russo RC,Stolarski B,Garcia CC,Komai-Koma M,Pitman N,Li Y,Niedbala W,McKenzie AN,Teixeira MM,Liew FY,Xu D
Wed Oct 01 00:00:00 UTC 2008
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A
Sat Nov 01 00:00:00 UTC 2008
Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Vassiliou EK,Kesler OM,Tadros JH,Ganea D
Wed Oct 01 00:00:00 UTC 2008
Galectin-1 promotes immunoglobulin production during plasma cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CM,Chiu YK,Hsu TL,Lin IY,Hsieh SL,Lin KI
Wed Oct 01 00:00:00 UTC 2008
IL-23 promotes maintenance but not commitment to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Stritesky GL,Yeh N,Kaplan MH
Sat Nov 01 00:00:00 UTC 2008
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors.
Journal of immunology (Baltimore, Md. : 1950)
Larmonier N,Janikashvili N,LaCasse CJ,Larmonier CB,Cantrell J,Situ E,Lundeen T,Bonnotte B,Katsanis E
Sat Nov 15 00:00:00 UTC 2008
Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.
Cancer biology & therapy
Benencia F,Courrèges MC,Fraser NW,Coukos G
214-14 was used in Enzyme-linked immunosorbent assay to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.
Fri Aug 01 00:00:00 UTC 2008
Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens.
Immunobiology
Littmann L,Rössner S,Kerek F,Steinkasserer A,Zinser E
Thu Feb 05 00:00:00 UTC 2009
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
Journal of immune based therapies and vaccines
Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW
Tue Oct 28 00:00:00 UTC 2008
Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions.
PloS one
Hatterer E,Touret M,Belin MF,Honnorat J,Nataf S
Thu Oct 02 00:00:00 UTC 2008
Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice.
PloS one
Lewkowich IP,Lajoie S,Clark JR,Herman NS,Sproles AA,Wills-Karp M
Fri Mar 20 00:00:00 UTC 2009
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.
PloS one
Sernández IV,de Yébenes VG,Dorsett Y,Ramiro AR
Mon Feb 23 00:00:00 UTC 2009
Aged B lymphocytes retain their ability to express surface markers but are dysfunctional in their proliferative capability during early activation events.
Immunity & ageing : I & A
Blaeser A,McGlauchlen K,Vogel LA
Mon Nov 17 00:00:00 UTC 2008
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
PloS one
Bauler TJ,Hendriks WJ,King PD
Thu Feb 19 00:00:00 UTC 2009
Immunomodulatory effects of aqueous birch pollen extracts and phytoprostanes on primary immune responses in vivo.
The Journal of allergy and clinical immunology
Gutermuth J,Bewersdorff M,Traidl-Hoffmann C,Ring J,Mueller MJ,Behrendt H,Jakob T
Wed Aug 01 00:00:00 UTC 2007
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ito K,Takubo K,Arai F,Satoh H,Matsuoka S,Ohmura M,Naka K,Azuma M,Miyamoto K,Hosokawa K,Ikeda Y,Mak TW,Suda T,Hirao A
Mon Jan 01 00:00:00 UTC 2007
FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Ekoff M,Strasser A,Nilsson G
Sun Apr 01 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature
Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ
Thu Aug 31 00:00:00 UTC 2006
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.
The Journal of experimental medicine
Usui T,Preiss JC,Kanno Y,Yao ZJ,Bream JH,O'Shea JJ,Strober W
Mon Mar 20 00:00:00 UTC 2006
Notch signaling is an important regulator of type 2 immunity.
The Journal of experimental medicine
Tu L,Fang TC,Artis D,Shestova O,Pross SE,Maillard I,Pear WS
Mon Oct 17 00:00:00 UTC 2005
B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yang M,Hase H,Legarda-Addison D,Varughese L,Seed B,Ting AT
Thu Sep 01 00:00:00 UTC 2005
Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Suto A,Nakajima H,Tokumasa N,Takatori H,Kagami S,Suzuki K,Iwamoto I
Tue Nov 01 00:00:00 UTC 2005
Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo.
Blood
Biragyn A,Ruffini PA,Coscia M,Harvey LK,Neelapu SS,Baskar S,Wang JM,Kwak LW
Fri Oct 01 00:00:00 UTC 2004
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs.
The Journal of clinical investigation
Furumoto K,Soares L,Engleman EG,Merad M
Mon Mar 01 00:00:00 UTC 2004
Basophils initiate IL-4 production during a memory T-dependent response.
The Journal of experimental medicine
Khodoun MV,Orekhova T,Potter C,Morris S,Finkelman FD
Mon Oct 04 00:00:00 UTC 2004
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 UTC 2004
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Verginis P,Stanford MM,Carayanniotis G
Fri Nov 01 00:00:00 UTC 2002
Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.
Journal of immunology (Baltimore, Md. : 1950)
Mathew A,Medoff BD,Carafone AD,Luster AD
Mon Jul 15 00:00:00 UTC 2002
IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stober D,Schirmbeck R,Reimann J
214-14 was used in Sample Preparation (ELISA) to study how dendritic cells (DCs) are a source of early IFN-gamma generated in response to a cascade of cytokine- and/or cell derived signals that can be positively and negatively regulated.
Sun Jul 15 00:00:00 UTC 2001
Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.
Cytokine
Ruth JH,Warmington KS,Shang X,Lincoln P,Evanoff H,Kunkel SL,Chensue SW
Mon May 01 00:00:00 UTC 2000
CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.
European journal of immunology
Nansen A,Marker O,Bartholdy C,Thomsen AR
214-14 was used in Cell Culture to correlate the expression of multiple chemokine and CC chemokine receptor (CCR) genes during the course of intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) and vesicular stomatitis virus (VSV), which are prototypic of a noncytopathic and a cytopathic virus, respectively.
Sat Jul 01 00:00:00 UTC 2000
Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor.
Journal of immunology (Baltimore, Md. : 1950)
Kageyama Y,Koide Y,Yoshida A,Uchijima M,Arai T,Miyamoto S,Ozeki T,Hiyoshi M,Kushida K,Inoue T
Sat Aug 01 00:00:00 UTC 1998
