Product References
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
315-02 was used in Cell Culture to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 UTC 2024
Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment.
JCI insight
Rosberg R,Smolag KI,Sjölund J,Johansson E,Bergelin C,Wahldén J,Pantazopoulou V,Ceberg C,Pietras K,Blom AM,Pietras A
315-02 was used in Cell Culture to establish a strong link between hypoxia and complement pathways in GBM, and support a role of hypoxia-induced C3a-C3aR signaling as a contributor to glioma aggressiveness by regulating macrophage polarization.
Thu Aug 22 00:00:00 UTC 2024
An Adaptable Protocol to Generate a Murine Enteroid-Macrophage Co-Culture System.
International journal of molecular sciences
Hentschel V,Govindarajan D,Seufferlein T,Armacki M
315-02 was used in In vitro experiments to provide step-by-step instructions on how to set up a murine enteroid-macrophage co-culture by culturing cellular elements in proximity separated by a porous membrane.
Sat Jul 20 00:00:00 UTC 2024
Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiao H,Du X,Tao Z,Jing N,Bao S,Gao WQ,Dong B,Fang YX
315-02 was used in Cell Culture to indicate a reciprocal interaction between PCa cells and TAMs as a positive feedback-loop to repress ferroptosis in PCa, mediated by TAM-secreted taurine and tumor EV-delivered miR-181a-5p.
Mon Jan 01 00:00:00 UTC 2024
Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression.
Journal of nanobiotechnology
Liu J,Xiang J,Jin C,Ye L,Wang L,Gao Y,Lv N,Zhang J,You F,Qiao H,Shi L
315-02 was used in Cell Culture to isolate and purify the exosome-like particles from A. annua, which were characterized by nano-scaled and membrane-bound shape and hence termed artemisia-derived nanovesicles.
Mon Mar 06 00:00:00 UTC 2023
TRPA1 deficiency aggravates dilated cardiomyopathy by promoting S100A8 expression to induce M1 macrophage polarization in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang M,Zhao M,Zheng Z,Pan W,Zhang J,Yin Z,Wei C,Xu Y,Wan J
315-02 was used in Cell Culture to suggest that TRPA1 deficiency aggravates DCM by promoting S100A8 expression to induce M1 macrophage polarization and cardiac apoptosis.
Thu Jun 01 00:00:00 UTC 2023
Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18.
Cell reports
Miyauchi S,Arimoto KI,Liu M,Zhang Y,Zhang DE
315-02 was used in Cell Culture to show that deletion of USP18 in myeloid cells suppresses tumor progression.
Tue Dec 26 00:00:00 UTC 2023
Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.
Theranostics
Chen L,Qin G,Liu Y,Li M,Li Y,Guo LZ,Du L,Zheng W,Wu PC,Chuang YH,Wang X,Wang TD,Ho JA,Liu TM
315-02 was used in In vitro experiments to successfully identifiy the differentiable features of prediabetic adipose tissues by employing the metabolic imaging of three endogenous fluorophores NAD(P)H, FAD, and lipofuscin-like pigments.
Mon Jul 17 00:00:00 UTC 2023
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
British journal of pharmacology
Wang Y,Gao J,Yu Y,Zhou L,Wang M,Xue W,Liu B,Wu X,Wu X,Gao H,Shen Y,Xu Q
315-02 was used in In vitro experiments to reveal that CA-e is a novel GR modulator with strong potency to attenuate the side effects of GC therapy and can be used as a potential molecular tool for deciphering GR signalling.
Sun Jan 01 00:00:00 UTC 2023
CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hou Y,Wang Y,Tang K,Yang Y,Wang Y,Liu R,Wu B,Chen X,Fu Z,Zhao F,Chen L
315-02 was used in In vitro experiments to reveal the pathogenic roles of CD226 played in the process of DCM and provided a basis for the treatment of DCM.
Tue Aug 01 00:00:00 UTC 2023
Site-Specific Modification of Virus-Like Particles for Exogenous Tumor Antigen Display and Minimizing Preexisting Immunity.
Small (Weinheim an der Bergstrasse, Germany)
Cheng K,Ma N,Liang J,Ma X,Feng Q,Liu G,Xu C,Tang M,Zhang L,Gao X,Xu J,Wang C,Zhu F,Wang X,Li X,Zhao X,Nie G
315-02 was used in Cell Culture to demonstrate the site-specific modification strategy enabled HBc VLPs behave as a potent antitumor vaccine.
Thu Jun 01 00:00:00 UTC 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
315-02 was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 UTC 2023
MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma.
Cancer discovery
Maddipati R,Norgard RJ,Baslan T,Rathi KS,Zhang A,Saeid A,Higashihara T,Wu F,Kumar A,Annamalai V,Bhattacharya S,Raman P,Adkisson CA,Pitarresi JR,Wengyn MD,Yamazoe T,Li J,Balli D,LaRiviere MJ,Ngo TC,Folkert IW,Millstein ID,Bermeo J,Carpenter EL,McAuliffe JC,Oktay MH,Brekken RA,Lowe SW,Iacobuzio-Donahue CA,Notta F,Stanger BZ
315-02 was used in Cell Culture to investigate metastatic variation seen clinically in patients with PDAC and murine PDAC tumors and identify MYC as a major driver of this heterogeneity.
Tue Feb 01 00:00:00 UTC 2022
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.
Cellular & molecular immunology
Ma X,Tan X,Yu B,Sun W,Wang H,Hu H,Du Y,He R,Gao R,Peng Q,Cui Z,Pan T,Feng X,Wang J,Xu C,Zhu B,Liu W,Wang C
315-02 was used in Cell Culture to not only identify a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA.
Sun May 01 00:00:00 UTC 2022
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
The Journal of experimental medicine
Masetti M,Carriero R,Portale F,Marelli G,Morina N,Pandini M,Iovino M,Partini B,Erreni M,Ponzetta A,Magrini E,Colombo P,Elefante G,Colombo FS,den Haan JMM,Peano C,Cibella J,Termanini A,Kunderfranco P,Brummelman J,Chung MWH,Lazzeri M,Hurle R,Casale P,Lugli E,DePinho RA,Mukhopadhyay S,Gordon S,Di Mitri D
Mon Feb 07 00:00:00 UTC 2022
Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis.
Arthritis & rheumatology (Hoboken, N.J.)
Zhai Z,Yang F,Xu W,Han J,Luo G,Li Y,Zhuang J,Jie H,Li X,Shi X,Han X,Luo X,Song R,Chen Y,Liang J,Wu S,He Y,Sun E
Tue Mar 01 00:00:00 UTC 2022
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation.
Small (Weinheim an der Bergstrasse, Germany)
Kwak G,Cheng J,Kim H,Song S,Lee SJ,Yang Y,Jeong JH,Lee JE,Messersmith PB,Kim SH
Fri Apr 01 00:00:00 UTC 2022
IL-6-elafin genetically modified macrophages as a lung immunotherapeutic strategy against Pseudomonas aeruginosa infections.
Molecular therapy : the journal of the American Society of Gene Therapy
Kheir S,Villeret B,Garcia-Verdugo I,Sallenave JM
Wed Jan 05 00:00:00 UTC 2022
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2.
Genes & development
Li Y,Kang S,Halawani D,Wang Y,Junqueira Alves C,Ramakrishnan A,Estill M,Shen L,Li F,He X,Friedel RH,Zou H
315-02 was used in Cell Culture to investigate Plexin-B2 requirement for macrophage and peripheral nerve regeneration.
Tue Feb 01 00:00:00 UTC 2022
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.
Cell death and differentiation
Vallelian F,Buzzi RM,Pfefferlé M,Yalamanoglu A,Dubach IL,Wassmer A,Gentinetta T,Hansen K,Humar R,Schulthess N,Schaer CA,Schaer DJ
Mon Aug 01 00:00:00 UTC 2022
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Mucosal immunology
Nagatake T,Kishino S,Urano E,Murakami H,Kitamura N,Konishi K,Ohno H,Tiwari P,Morimoto S,Node E,Adachi J,Abe Y,Isoyama J,Sawane K,Honda T,Inoue A,Uwamizu A,Matsuzaka T,Miyamoto Y,Hirata SI,Saika A,Shibata Y,Hosomi K,Matsunaga A,Shimano H,Arita M,Aoki J,Oka M,Matsutani A,Tomonaga T,Kabashima K,Miyachi M,Yasutomi Y,Ogawa J,Kunisawa J
Tue Feb 01 00:00:00 UTC 2022
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Immunology
Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O
Sun May 01 00:00:00 UTC 2022
Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress.
Journal of cellular physiology
Wu S,Romero-Ramírez L,Mey J
Tue Feb 01 00:00:00 UTC 2022
Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice.
Journal of cellular physiology
Shin HR,Kim BS,Kim HJ,Yoon H,Kim WJ,Choi JY,Ryoo HM
Fri Apr 01 00:00:00 UTC 2022
Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery.
Neural regeneration research
Zhang K,Lu WC,Zhang M,Zhang Q,Xian PP,Liu FF,Chen ZY,Kim CS,Wu SX,Tao HR,Wang YZ
315-02 was used in Cell Culture to suggest that inhibition of host AR activity is beneficial in enhancing the survival and neuronal differentiation of transplanted NSCs and shows potential as a treatment of spinal cord injury.
Mon Aug 01 00:00:00 UTC 2022
The cation channel TRPM8 influences the differentiation and function of human monocytes.
Journal of leukocyte biology
Hornsby E,King HW,Peiris M,Buccafusca R,Lee WJ,Wing ES,Blackshaw LA,Lindsay JO,Stagg AJ
Thu Sep 01 00:00:00 UTC 2022
A homozygous hypomorphic BNIP1 variant causes an increase in autophagosomes and reduced autophagic flux and results in a spondylo-epiphyseal dysplasia.
Human mutation
Holling T,Bhavani GS,von Elsner L,Shah H,Kausthubham N,Bhattacharyya SS,Shukla A,Mortier GR,Schinke T,Danyukova T,Pohl S,Kutsche K,Girisha KM
Sun May 01 00:00:00 UTC 2022
Ferric Ammonium Citrate Upregulates PD-L1 Expression through Generation of Reactive Oxygen Species.
Journal of immunology research
Choi EJ,Jeon CH,Lee IK
Wed Mar 16 00:00:00 UTC 2022
Feibi decoction-medicated serum inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells and BMDMs.
Experimental and therapeutic medicine
Wei W,Li G,Liu Z,Yang H,Liu S,Zou X,Jiao Y
315-02 was used in Cell Culture to investigate the effect of Feibi decoction-medicated serum on lipopolysaccharide-induced inflammation in macrophages.
Sat Jan 01 00:00:00 UTC 2022
Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation.
iScience
McGowan ENS,Wong O,Jones E,Nguyen J,Wee J,Demaria MC,Deliyanti D,Johnson CJ,Hickey MJ,McConville MJ,Wilkinson-Berka JL,Wright MD,Binger KJ
315-02 was used in In vitro experiments to reveal an important role for CD82 in restraining phagocyte infiltration and mediating their differentiation in response to stimulatory cues.
Fri Jul 15 00:00:00 UTC 2022
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.
Nature communications
Yong L,Yu Y,Li B,Ge H,Zhen Q,Mao Y,Yu Y,Cao L,Zhang R,Li Z,Wang Y,Fan W,Zhang C,Wang D,Luo S,Bai Y,Chen S,Chen W,Liu M,Shen J,Sun L
315-02 was used in Cell Culture to investigate CaMK4 expression in psoriasis.
Fri Jul 22 00:00:00 UTC 2022
In vitro analyses of paracrine effects of murine classically activated macrophage on beige adipocyte metabolism.
STAR protocols
Yao J,Wu D,Qiu Y
315-02 was used in Cell Culture to provide a protocol using differentiated cells to investigate the paracrine effects of classically activated macrophages on beige adipocyte metabolism in vitro.
Fri Sep 16 00:00:00 UTC 2022
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.
JCI insight
Tsao LC,Crosby EJ,Trotter TN,Wei J,Wang T,Yang X,Summers AN,Lei G,Rabiola CA,Chodosh LA,Muller WJ,Lyerly HK,Hartman ZC
315-02 was used in Sample Preparation (FC/FACS) to identify classical complement activation as a significant antitumor MOA for T+P therapy that may be functionally enhanced to potentially augment clinical therapeutic efficacy.
Tue Mar 22 00:00:00 UTC 2022
C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Nature communications
Park I,Goddard ME,Cole JE,Zanin N,Lyytikäinen LP,Lehtimäki T,Andreakos E,Feldmann M,Udalova I,Drozdov I,Monaco C
Tue Jan 11 00:00:00 UTC 2022
Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America
LaRue MM,Parker S,Puccini J,Cammer M,Kimmelman AC,Bar-Sagi D
315-02 was used in Cell Culture to identify a role for extracellular matrix remodeling in the functional modulation of tumor-associated macrophages via metabolic rewiring.
Tue Apr 19 00:00:00 UTC 2022
Deletion of IL-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance.
Bone
Roberts JL,Mella-Velazquez G,Dar HY,Liu G,Drissi H
315-02 was used in Cell Culture to suggest that IL-17ra signaling in preosteoclasts can contribute to osteoclast formation and subsequent bone loss.
Fri Apr 01 00:00:00 UTC 2022
Baicalein-A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury.
Frontiers in immunology
Pan L,Sze YH,Yang M,Tang J,Zhao S,Yi I,To CH,Lam C,Chen DF,Cho KS,Do CW
315-02 was used in Immunohistochemistry to investigate the role of baicalein on the regulation of microglia in retinal ischemia.
Mon May 02 00:00:00 UTC 2022
Mesenchymal stem cells alleviate systemic sclerosis by inhibiting the recruitment of pathogenic macrophages.
Cell death discovery
Gong P,Ding Y,Sun R,Jiang Z,Li W,Su X,Tian R,Zhou Y,Wang T,Jiang J,Li P,Shao C,Shi Y
315-02 was used in Cell Culture to find that IFN-γ- and TNF-α-pretreated MSCs significantly alleviated skin fibrosis in a bleomycin (BLM)-induced SSc model.
Sat Nov 26 00:00:00 UTC 2022
Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.
Cancer medicine
Zhang S,Wang H,Liu Y,Tao T,Zeng Z,Zhou Y,Wang M
315-02 was used in Cell Culture to suggest that Nr-CWS can promote apoptosis of cervical carcinoma cells by enhancing the antitumor effect of dendritic cells and macrophages.
Tue Mar 01 00:00:00 UTC 2022
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response.
Cell reports
Cobo I,Cheng A,Murillo-Saich J,Coras R,Torres A,Abe Y,Lana AJ,Schlachetzki J,Liu-Bryan R,Terkeltaub R,Sanchez-Lopez E,Glass CK,Guma M
315-02 was used in Cell Culture to demonstrate that MSUc alone induce a metabolic-inflammatory transcriptional program in non-primed human and murine macrophages that is markedly distinct to that induced by LPS.
Tue Mar 08 00:00:00 UTC 2022
Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization.
iScience
Cheng Y,Yu Y,Zhuang Q,Wang L,Zhan B,Du S,Liu Y,Huang J,Hao J,Zhu X
315-02 was used in Cell Culture to investigate helminths in rheumatoid arthritis treatment.
Fri Mar 18 00:00:00 UTC 2022
Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.
Science advances
Bonadonna M,Altamura S,Tybl E,Palais G,Qatato M,Polycarpou-Schwarz M,Schneider M,Kalk C,Rüdiger W,Ertl A,Anstee N,Bogeska R,Helm D,Milsom MD,Galy B
315-02 was used in Cell Culture to report that global disruption of both iron-regulatory protein 1 (IRP1) and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia.
Fri Oct 07 00:00:00 UTC 2022
Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.
Nature protocols
Hajal C,Offeddu GS,Shin Y,Zhang S,Morozova O,Hickman D,Knutson CG,Kamm RD
Sat Jan 01 00:00:00 UTC 2022
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis.
Nature cardiovascular research
Jarr KU,Ye J,Kojima Y,Ye Z,Gao H,Schmid S,Luo L,Baylis RA,Lotfi M,Lopez N,Eberhard AV,Smith BR,Weissman IL,Maegdefessel L,Leeper NJ
315-02 was used in Cell Culture to study gene expression patterns following CD47-SIRPα inhibition and statins benefits.
Tue Mar 01 00:00:00 UTC 2022
Nrf2 Deficiency Exacerbated CLP-Induced Pulmonary Injury and Inflammation through Autophagy- and NF-κB/PPARγ-Mediated Macrophage Polarization.
Cells
Luo J,Wang J,Zhang J,Sang A,Ye X,Cheng Z,Li X
315-02 was used in Cell Culture to indicate that Nrf2 plays a protective role in sepsis-induced pulmonary injury and inflammation through the regulation of autophagy- and NF-κB/PPARγ-mediated macrophage polarization.
Sun Dec 04 00:00:00 UTC 2022
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Nature communications
Klapproth E,Witt A,Klose P,Wiedemann J,Vavilthota N,Künzel SR,Kämmerer S,Günscht M,Sprott D,Lesche M,Rost F,Dahl A,Rauch E,Kattner L,Weber S,Mirtschink P,Kopaliani I,Guan K,Lorenz K,Saftig P,Wagner M,El-Armouche A
315-02 was used in In vitro experiments to demonstrate distinct role of (ADAM10)/CX3CL1 axis in the regulation of neutrophil recruitment early after MI towards improved prognosis.
Sat Dec 10 00:00:00 UTC 2022
Sympathetic Neurostress Drives Osteoblastic Exosomal MiR-21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia.
Small methods
Hu CH,Sui BD,Liu J,Dang L,Chen J,Zheng CX,Shi S,Zhao N,Dang MY,He XN,Zhang LQ,Gao PP,Chen N,Kuang HJ,Chen K,Xu XL,Yu XR,Zhang G,Jin Y
315-02 was used in Cell Culture to state that sympathetic neurostress through the β1/2 -adrenergic receptor (β1/2-AR) signaling triggers the transcription response of a microRNA, miR-21, in osteoblasts, which is transferred to osteoclast progenitors via exosomes for dictating osteoclastogenesis.
Tue Mar 01 00:00:00 UTC 2022
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
Cell reports
Alam MM,Yang D,Li XQ,Liu J,Back TC,Trivett A,Karim B,Barbut D,Zasloff M,Oppenheim JJ
315-02 was used in Cell Culture to show that αS is a critical mediator of inflammatory and immune responses.
Tue Jan 11 00:00:00 UTC 2022
An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
Cell reports methods
Aktories P,Petry P,Glatz P,Andrieux G,Oschwald A,Botterer H,Gorka O,Erny D,Boerries M,Henneke P,Groß O,Prinz M,Kierdorf K
315-02 was used in Cell Culture to conclude that his organotypic system offers an ideal screening platform for primary macrophages from different organs that can be used for a wide range of assays and readouts.
Mon Aug 22 00:00:00 UTC 2022
Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro.
Frontiers in pharmacology
Wang J,Wang Y,Huang R,Li W,Fan W,Hu X,Yang X,Han Q,Wang H,Liu G
315-02 was used in Cell Culture to provide a theoretical basis for further preclinical evaluation and lay a foundation for nano-gel compound treatment with Zizhu ointment.
Tue Sep 10 00:00:00 UTC 2024
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.
Nature metabolism
Schuster EM,Epple MW,Glaser KM,Mihlan M,Lucht K,Zimmermann JA,Bremser A,Polyzou A,Obier N,Cabezas-Wallscheid N,Trompouki E,Ballabio A,Vogel J,Buescher JM,Westermann AJ,Rambold AS
315-02 was used in Tissue/organ culture to identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for phago-lysosome-mitochondria crosstalk in macrophages.
Fri Jul 01 00:00:00 UTC 2022
Macrophage network dynamics depend on haptokinesis for optimal local surveillance.
eLife
Paterson N,Lämmermann T
315-02 was used in Cell Culture to investigate the effects of of cell shape and motility on macrophage network and populations.
Mon Mar 28 00:00:00 UTC 2022
Targeting Macrophages with CAR T Cells Delays Solid Tumor Progression and Enhances Antitumor Immunity.
Cancer immunology research
Sánchez-Paulete AR,Mateus-Tique J,Mollaoglu G,Nielsen SR,Marks A,Lakshmi A,Khan JA,Wilk CM,Pia L,Baccarini A,Merad M,Brown BD
315-02 was used in Cell Culture to provide proof of principle to support CAR T-cell targeting of TAMs as a means to enhance antitumor immunity.
Wed Nov 02 00:00:00 UTC 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 UTC 2022
Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment.
FASEB bioAdvances
Dai H,Lou S,Zhang Y,Thanawala M,Huang KC,Ji L,Carden S,Liao T,Abbassi M,Shu CJ,Lantermann A,Sadaghiani M,Blom D,Wagner J,Huang P
Sat Jan 01 00:00:00 UTC 2022
Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions.
Cell death & disease
Sarkar J,Das M,Howlader MSI,Prateeksha P,Barthels D,Das H
315-02 was used in Cell Culture to investigate the role of epigallocatechin-3-gallate on osteocalstogenesis.
Fri Oct 28 00:00:00 UTC 2022
Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics.
Scientific reports
Soma T,Iwasaki R,Sato Y,Kobayashi T,Ito E,Matsumoto T,Kimura A,Miyamoto K,Matsumoto M,Nakamura M,Morita M,Asoda S,Kawana H,Nakagawa T,Miyamoto T
Fri Jan 07 00:00:00 UTC 2022
Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses.
STAR protocols
Milner MT,Lawrence GM,Holley CL,Bodea LG,Götz J,Burgener SS,Schroder K
315-02 was used in Cell Culture to provide a protocol for the isolation and culturing of glial cells from the murine brain.
Fri Jun 17 00:00:00 UTC 2022
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Nature
Casanova-Acebes M,Dalla E,Leader AM,LeBerichel J,Nikolic J,Morales BM,Brown M,Chang C,Troncoso L,Chen ST,Sastre-Perona A,Park MD,Tabachnikova A,Dhainaut M,Hamon P,Maier B,Sawai CM,Agulló-Pascual E,Schober M,Brown BD,Reizis B,Marron T,Kenigsberg E,Moussion C,Benaroch P,Aguirre-Ghiso JA,Merad M
Thu Jul 01 00:00:00 UTC 2021
Aged skeletal stem cells generate an inflammatory degenerative niche.
Nature
Ambrosi TH,Marecic O,McArdle A,Sinha R,Gulati GS,Tong X,Wang Y,Steininger HM,Hoover MY,Koepke LS,Murphy MP,Sokol J,Seo EY,Tevlin R,Lopez M,Brewer RE,Mascharak S,Lu L,Ajanaku O,Conley SD,Seita J,Morri M,Neff NF,Sahoo D,Yang F,Weissman IL,Longaker MT,Chan CKF
Wed Sep 01 00:00:00 UTC 2021
The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.
Nature
Fidler TP,Xue C,Yalcinkaya M,Hardaway B,Abramowicz S,Xiao T,Liu W,Thomas DG,Hajebrahimi MA,Pircher J,Silvestre-Roig C,Kotini AG,Luchsinger LL,Wei Y,Westerterp M,Snoeck HW,Papapetrou EP,Schulz C,Massberg S,Soehnlein O,Ebert B,Levine RL,Reilly MP,Libby P,Wang N,Tall AR
315-02 was used in Sample Preparation (Western Blotting) to investigate JAK2VF mutations in haematopoiesis and macrophage proliferation.
Thu Apr 01 00:00:00 UTC 2021
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing.
Cell metabolism
Willenborg S,Sanin DE,Jais A,Ding X,Ulas T,Nüchel J,Popović M,MacVicar T,Langer T,Schultze JL,Gerbaulet A,Roers A,Pearce EJ,Brüning JC,Trifunovic A,Eming SA
Tue Dec 07 00:00:00 UTC 2021
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation.
Cell host & microbe
Viladomiu M,Metz ML,Lima SF,Jin WB,Chou L,Guo CJ,Diehl GE,Simpson KW,Scherl EJ,Longman RS
315-02 was used in Cell Culture to identify MNPs as metabolic sensors linking AIEC metabolism with intestinal inflammation and identify microbial metabolism as a potential therapeutic target in Crohn's disease treatment.
Wed Apr 14 00:00:00 UTC 2021
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases.
Cellular & molecular immunology
Hou P,Lin Y,Li Z,Lu R,Wang Y,Tian T,Jia P,Zhang X,Cao L,Zhou Z,Li C,Gu J,Guo D
Fri Oct 01 00:00:00 UTC 2021
White matter aging drives microglial diversity.
Neuron
Safaiyan S,Besson-Girard S,Kaya T,Cantuti-Castelvetri L,Liu L,Ji H,Schifferer M,Gouna G,Usifo F,Kannaiyan N,Fitzner D,Xiang X,Rossner MJ,Brendel M,Gokce O,Simons M
Wed Apr 07 00:00:00 UTC 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 UTC 2021
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes.
The Journal of experimental medicine
Kosaka A,Ishibashi K,Nagato T,Kitamura H,Fujiwara Y,Yasuda S,Nagata M,Harabuchi S,Hayashi R,Yajima Y,Ohara K,Kumai T,Aoki N,Komohara Y,Oikawa K,Harabuchi Y,Kitada M,Kobayashi H,Ohkuri T
Mon Nov 01 00:00:00 UTC 2021
Hematopoietic stem and progenitor cells are present in healthy gingiva tissue.
The Journal of experimental medicine
Krishnan S,Wemyss K,Prise IE,McClure FA,O'Boyle C,Bridgeman HM,Shaw TN,Grainger JR,Konkel JE
Mon Apr 05 00:00:00 UTC 2021
The SIRPα-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S
Mon Mar 01 00:00:00 UTC 2021
Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.
The EMBO journal
Wang Y,Sharma P,Jefferson M,Zhang W,Bone B,Kipar A,Bitto D,Coombes JL,Pearson T,Man A,Zhekova A,Bao Y,Tripp RA,Carding SR,Yamauchi Y,Mayer U,Powell PP,Stewart JP,Wileman T
Mon Mar 15 00:00:00 UTC 2021
Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.
The EMBO journal
Wang Y,Sharma P,Jefferson M,Zhang W,Bone B,Kipar A,Bitto D,Coombes JL,Pearson T,Man A,Zhekova A,Bao Y,Tripp RA,Carding SR,Yamauchi Y,Mayer U,Powell PP,Stewart JP,Wileman T
Mon Mar 15 00:00:00 UTC 2021
Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Autophagy
Ko MS,Yun JY,Baek IJ,Jang JE,Hwang JJ,Lee SE,Heo SH,Bader DA,Lee CH,Han J,Moon JS,Lee JM,Hong EG,Lee IK,Kim SW,Park JY,Hartig SM,Kang UJ,Moore DD,Koh EH,Lee KU
315-02 was used in Cell Culture to investigate the role of autophagy in brown adipose tissue in body weight regulation.
Sat May 01 00:00:00 UTC 2021
Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.
Bone research
Yu W,Chen C,Kou X,Sui B,Yu T,Liu D,Wang R,Wang J,Shi S
Fri Jan 01 00:00:00 UTC 2021
Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases.
Bone research
Polavaram NS,Dutta S,Islam R,Bag AK,Roy S,Poitz D,Karnes J,Hofbauer LC,Kohli M,Costello BA,Jimenez R,Batra SK,Teply BA,Muders MH,Datta K
Fri May 14 00:00:00 UTC 2021
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Proceedings of the National Academy of Sciences of the United States of America
Yum S,Li M,Fang Y,Chen ZJ
Tue Apr 06 00:00:00 UTC 2021
Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Upton R,Banuelos A,Feng D,Biswas T,Kao K,McKenna K,Willingham S,Ho PY,Rosental B,Tal MC,Raveh T,Volkmer JP,Pegram MD,Weissman IL
Tue Jul 20 00:00:00 UTC 2021
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss.
Experimental & molecular medicine
Lee SY,Park KH,Lee G,Kim SJ,Song WH,Kwon SH,Koh JT,Huh YH,Ryu JH
Thu Apr 01 00:00:00 UTC 2021
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Cell death and differentiation
Chen X,Guan Y,Zhang Y,Jia Y,Li W,Guo C,Li Y,Wang X,Shi Y,Wang Q,Zhu F,Li Y,Zhang L
315-02 was used in Cell Culture to reveal a novel PDCD4-dependent TFEB translational regulation and supports PDCD4 as a potential therapeutic target for lysosome dysfunction related diseases.
Thu Apr 01 00:00:00 UTC 2021
Extrinsic Macrophages Protect While Tendon Progenitors Degrade: Insights from a Tissue Engineered Model of Tendon Compartmental Crosstalk.
Advanced healthcare materials
Stauber T,Wolleb M,Duss A,Jaeger PK,Heggli I,Hussien AA,Blache U,Snedeker JG
315-02 was used in Sample Preparation (FC/FACS) to show that it is found that extrinsic bone-marrow derived macrophages in these conditions adopt a proresolution phenotype that mitigates rapid tissue breakdown by outwardly migrated tenocytes and F4/80+ tenophages" from the intrinsic tissue core."
Fri Oct 01 00:00:00 UTC 2021
Extrinsic Macrophages Protect While Tendon Progenitors Degrade: Insights from a Tissue Engineered Model of Tendon Compartmental Crosstalk.
Advanced healthcare materials
Stauber T,Wolleb M,Duss A,Jaeger PK,Heggli I,Hussien AA,Blache U,Snedeker JG
315-02 was used in Sample Preparation (FC/FACS) to show that it is found that extrinsic bone-marrow derived macrophages in these conditions adopt a proresolution phenotype that mitigates rapid tissue breakdown by outwardly migrated tenocytes and F4/80+ tenophages" from the intrinsic tissue core."
Fri Oct 01 00:00:00 UTC 2021
E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice.
Arteriosclerosis, thrombosis, and vascular biology
Xu (许艳妮) Y,Liu (刘畅) C,Han (韩小婉) X,Jia (贾晓健) X,Li (李永臻) Y,Liu (刘超) C,Li (李霓) N,Liu (刘伦铭) L,Liu (刘鹏) P,Jiang (姜新海) X,Wang (王伟志) W,Wang (王潇) X,Li (李依宁) Y,Chen (陈明珠) M,Luo (罗金雀) J,Zuo (左璇) X,Han (韩江雪) J,Wang (王丽) L,Du (杜郁) Y,Xu (徐扬) Y,Jiang (蒋建东) JD,Hong (洪斌) B,Si (司书毅) S
315-02 was used in Sample Preparation (Western Blotting) to investigate E17241 stimulation of reverse cholesterol transport by ABCA1 to treat atherosclerosis.
Tue Jun 01 00:00:00 UTC 2021
Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits of GlcNAc-1-phosphotransferase differentially impact bone resorption in patients with mucolipidosis type II and III.
Genetics in medicine : official journal of the American College of Medical Genetics
Di Lorenzo G,Westermann LM,Yorgan TA,Stürznickel J,Ludwig NF,Ammer LS,Baranowsky A,Ahmadi S,Pourbarkhordariesfandabadi E,Breyer SR,Board TN,Foster A,Mercer J,Tylee K,Velho RV,Schweizer M,Renné T,Braulke T,Randon DN,Sperb-Ludwig F,de Camargo Pinto LL,Moreno CA,Cavalcanti DP,Amling M,Kutsche K,Winter D,Muschol NM,Schwartz IVD,Rolvien T,Danyukova T,Schinke T,Pohl S
Wed Dec 01 00:00:00 UTC 2021
The calcium channel TRPV6 is a novel regulator of RANKL-induced osteoclastic differentiation and bone absorption activity through the IGF-PI3K-AKT pathway.
Cell proliferation
Ma J,Zhu L,Zhou Z,Song T,Yang L,Yan X,Chen A,Ye TW
Fri Jan 01 00:00:00 UTC 2021
Essential role of M1 macrophages in blocking cytokine storm and pathology associated with murine HSV-1 infection.
PLoS pathogens
Jaggi U,Matundan HH,Yu J,Hirose S,Mueller M,Wormley FL,Ghiasi H
315-02 was used in Sample Preparation (FC/FACS) to study the role and importance of M1 macrophages in HSV-1 infection and eye disease.
Fri Oct 01 00:00:00 UTC 2021
NR1D1 Deletion Induces Rupture-Prone Vulnerable Plaques by Regulating Macrophage Pyroptosis via the NF-κB/NLRP3 Inflammasome Pathway.
Oxidative medicine and cellular longevity
Wu Z,Liao F,Luo G,Qian Y,He X,Xu W,Ding S,Pu J
Thu Mar 03 00:00:00 UTC 2022
M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis.
Oxidative medicine and cellular longevity
Chen B,Luo L,Wei X,Gong D,Li Z,Li S,Tang W,Jin L
Thu Feb 17 00:00:00 UTC 2022
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.
Acta pharmacologica Sinica
Deng Y,Hu JC,He SH,Lou B,Ding TB,Yang JT,Mo MG,Ye DY,Zhou L,Jiang XC,Yu K,Dong JB
315-02 was used in Cell Culture to reveal a novel and important role of SMS2 in the protumorigenic function and may offer a new strategy for macrophage-targeted anticancer therapy.
Fri Jan 01 00:00:00 UTC 2021
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Acta pharmacologica Sinica
Wu YX,Wang YY,Gao ZQ,Chen D,Liu G,Wan BB,Jiang FJ,Wei MX,Zuo J,Zhu J,Chen YQ,Qian F,Pang QF
Wed Dec 01 00:00:00 UTC 2021
Retinoic acid increases phagocytosis of myelin by macrophages.
Journal of cellular physiology
Wu S,Romero-Ramírez L,Mey J
Sat May 01 00:00:00 UTC 2021
Acvr1 deletion in osteoblasts impaired mandibular bone mass through compromised osteoblast differentiation and enhanced sRANKL-induced osteoclastogenesis.
Journal of cellular physiology
Hu Y,Hao X,Liu C,Ren C,Wang S,Yan G,Meng Y,Mishina Y,Shi C,Sun H
Tue Jun 01 00:00:00 UTC 2021
Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hendrickx G,Fischer V,Liedert A,von Kroge S,Haffner-Luntzer M,Brylka L,Pawlus E,Schweizer M,Yorgan T,Baranowsky A,Rolvien T,Neven M,Schumacher U,Beech DJ,Amling M,Ignatius A,Schinke T
Mon Feb 01 00:00:00 UTC 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
315-02 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Apr 03 00:00:00 UTC 2024
Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity.
Cancer gene therapy
Choi Y,Nam GH,Kim GB,Kim S,Kim YK,Kim SA,Kim HJ,Lee EJ,Kim IS
Wed Sep 01 00:00:00 UTC 2021
Single-Cell Transcriptome Profiles Reveal Fibrocytes as Potential Targets of Cell Therapies for Abdominal Aortic Aneurysm.
Frontiers in cardiovascular medicine
Li B,Song X,Guo W,Hou Y,Hu H,Ge W,Fan T,Han Z,Li Z,Yang P,Gao R,Zhao H,Wang J
315-02 was used in Cell Culture to determine the roles of different vascular and immune cells in abdominal aortic aneurysm formation and pathogenesis.
Wed Dec 15 00:00:00 UTC 2021
Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity.
Frontiers in oncology
Natoli M,Herzig P,Pishali Bejestani E,Buchi M,Ritschard R,Lloyd GK,Mohanlal R,Tonra JR,Huang L,Heinzelmann V,Trüb M,Zippelius A,Kashyap AS
315-02 was used in Cell Culture to investigate plinabulin and the effects on dendritic cell maturation and anti-tumor immunity in mice.
Tue Mar 23 00:00:00 UTC 2021
TRAM-Related TLR4 Pathway Antagonized by IRAK-M Mediates the Expression of Adhesion/Coactivating Molecules on Low-Grade Inflammatory Monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Pradhan K,Geng S,Zhang Y,Lin RC,Li L
Tue Jun 15 00:00:00 UTC 2021
Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Luo M,Lai W,He Z,Wu L
Wed Sep 15 00:00:00 UTC 2021
The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Xu N,Bai X,Liu Y,Yang Y,Tang B,Shi HN,Vallee I,Boireau P,Liu X,Liu M
Mon Mar 01 00:00:00 UTC 2021
Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).
Journal of immunology (Baltimore, Md. : 1950)
Fraszczak J,Arman KM,Lacroix M,Vadnais C,Gaboury L,Möröy T
Wed Sep 15 00:00:00 UTC 2021
A Monocyte-Orchestrated IFN-I-to-IL-4 Cytokine Axis Instigates Protumoral Macrophages and Thwarts Poly(I:C) Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Guo P,Yang L,Zhang M,Zhang Y,Tong Y,Cao Y,Liu J
Thu Jul 15 00:00:00 UTC 2021
N-[2-(4-benzoyl-1-piperazinyl)phenyl]-2-(4-chlorophenoxy) acetamide is a novel inhibitor of resorptive bone loss in mice.
Journal of cellular and molecular medicine
Chen Z,Cho E,Ding M,Seong J,Che X,Lee S,Park BJ,Choi JY,Lee TH
Mon Feb 01 00:00:00 UTC 2021
Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-β1/Smad3 pathway.
Journal of cellular and molecular medicine
Ying H,Fang M,Hang QQ,Chen Y,Qian X,Chen M
Wed Sep 01 00:00:00 UTC 2021
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca2+ /calmodulin-mediated osteoclast differentiation.
Journal of cellular and molecular medicine
Lee HY,Cho KM,Kim MK,Lee M,Kim H,Choi CY,Kim KK,Park JS,Kim HH,Bae YS
Fri Jan 01 00:00:00 UTC 2021
Dental pulp-derived stem cells inhibit osteoclast differentiation by secreting osteoprotegerin and deactivating AKT signalling in myeloid cells.
Journal of cellular and molecular medicine
Kanji S,Sarkar R,Pramanik A,Kshirsagar S,Greene CJ,Das H
Mon Mar 01 00:00:00 UTC 2021
Dental pulp-derived stem cells inhibit osteoclast differentiation by secreting osteoprotegerin and deactivating AKT signalling in myeloid cells.
Journal of cellular and molecular medicine
Kanji S,Sarkar R,Pramanik A,Kshirsagar S,Greene CJ,Das H
Mon Mar 01 00:00:00 UTC 2021
Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
Journal of neuro-oncology
Crotty EE,Smith SMC,Brasel K,Pakiam F,Girard EJ,Connor YD,Zindy F,Mhyre AJ,Roussel MF,Olson JM
315-02 was used in Cell Culture to investigate the role of tumour-associated macrophage infiltration in cancer progression.
Tue Jun 01 00:00:00 UTC 2021
Chirality-Dependent Anti-Inflammatory Effect of Glutathione after Spinal Cord Injury in an Animal Model.
Pharmaceuticals (Basel, Switzerland)
Kim SJ,Ko WK,Han GH,Lee D,Lee Y,Sheen SH,Hong JB,Sohn S
315-02 was used in Cell Culture to reveal a potential new regenerative function of chiral GSH in SCI and suggest that chiral GSH has therapeutic potential as a treatment of other diseases.
Thu Aug 12 00:00:00 UTC 2021
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience
Lai JH,Wu DW,Wu CH,Hung LF,Huang CY,Ka SM,Chen A,Chang ZF,Ho LJ
Fri Jun 25 00:00:00 UTC 2021
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience
Lai JH,Wu DW,Wu CH,Hung LF,Huang CY,Ka SM,Chen A,Chang ZF,Ho LJ
Fri Jun 25 00:00:00 UTC 2021
A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.
Cell reports
Fremder M,Kim SW,Khamaysi A,Shimshilashvili L,Eini-Rider H,Park IS,Hadad U,Cheon JH,Ohana E
Tue Aug 10 00:00:00 UTC 2021
MMP2 and TLRs modulate immune responses in the tumor microenvironment.
JCI insight
Muniz-Bongers LR,McClain CB,Saxena M,Bongers G,Merad M,Bhardwaj N
315-02 was used in In vitro experiments to study the role of matrix metalloproteinase 2 (MMP2) in melanoma tumorigenesis.
Tue Jun 22 00:00:00 UTC 2021
Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.
Scientific reports
Yamada H,Saegusa J,Sendo S,Ueda Y,Okano T,Shinohara M,Morinobu A
Fri Aug 27 00:00:00 UTC 2021
Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.
Scientific reports
Jones RE,Andrews R,Holmans P,Hill M,Taylor PR
Thu Jul 22 00:00:00 UTC 2021
Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA).
Cell death & disease
Klaas L,Vier J,Gentle IE,Häcker G,Kirschnek S
Thu Oct 28 00:00:00 UTC 2021
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Cell reports
Shen Y,Tang K,Chen D,Hong M,Sun F,Wang S,Ke Y,Wu T,Sun R,Qian J,Du Y
Tue Jun 22 00:00:00 UTC 2021
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance.
Cell reports
Li X,Zhang X,Xia J,Zhang L,Chen B,Lian G,Yun C,Yang J,Yan Y,Wang P,Wang X,Liu B,Liu H,Liang H,Pang Y,Wang X,Jiang C
Tue Aug 24 00:00:00 UTC 2021
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements.
Antioxidants (Basel, Switzerland)
Christopoulos PF,Grigalavicius M,Corthay A,Berg K,Theodossiou TA
315-02 was used in Cell Culture to investigate mitochondrial oxygen consumption in macrophage activation.
Tue Jul 20 00:00:00 UTC 2021
RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.
Cell reports
Sun R,He L,Lee H,Glinka A,Andresen C,Hübschmann D,Jeremias I,Müller-Decker K,Pabst C,Niehrs C
Tue Aug 17 00:00:00 UTC 2021
Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll-like receptor 2.
Journal of extracellular vesicles
Kim HY,Song MK,Gho YS,Kim HH,Choi BK
Fri Oct 01 00:00:00 UTC 2021
MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease.
International journal of molecular sciences
Lai YS,Nguyen HT,Salmanida FP,Chang KT
315-02 was used in Sample Preparation (FC/FACS) to conclude that cell-based therapy using MERTK+/hi M2c macrophages is promising, as it ameliorates NAFLD in mice.
Thu Sep 30 00:00:00 UTC 2021
Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera.
Nature communications
Poganik JR,Huang KT,Parvez S,Zhao Y,Raja S,Long MJC,Aye Y
Thu Sep 30 00:00:00 UTC 2021
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Nature communications
Muñoz-Rojas AR,Kelsey I,Pappalardo JL,Chen M,Miller-Jensen K
Tue Jan 12 00:00:00 UTC 2021
TRPV6 is a potential regulator of bone resorption in bone loss induced by estrogen deficiency.
iScience
Ma J,Lu J,Zhou Z,Lu N,He J,Zhu L,Ye T
Fri Nov 19 00:00:00 UTC 2021
Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota.
Scientific reports
Kitabatake M,Matsumura Y,Ouji-Sageshima N,Nishioka T,Hara A,Kayano SI,Ito T
Wed Mar 31 00:00:00 UTC 2021
Characterization and Functional Analysis of Tumor-Derived Microparticles.
Current protocols
Ma J,Tang K,Zhang H,Wei K,Huang B
Tue Jun 01 00:00:00 UTC 2021
Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
Cell death & disease
He Y,Cheng D,Lian C,Liu Y,Luo W,Wang Y,Ma C,Wu Q,Tian P,He D,Jia Z,Lv X,Zhang X,Pan Z,Lu J,Xiao Y,Zhang P,Liang Y,Yang Q,Hu G
Thu Sep 23 00:00:00 UTC 2021
Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain.
Frontiers in cellular neuroscience
Wang F,Ma XR,Wu Y,Xu YC,Gu HM,Wang DX,Dong ZJ,Li HL,Wang LB,Zhao JW
315-02 was used in Cell Culture to investigate mechanisms regulating migration in microglia and macrophages in wound healing for the central nervous system.
Wed Nov 10 00:00:00 UTC 2021
High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
iScience
Bouchareychas L,Duong P,Phu TA,Alsop E,Meechoovet B,Reiman R,Ng M,Yamamoto R,Nakauchi H,Gasper WJ,Van Keuren-Jensen K,Raffai RL
Fri Aug 20 00:00:00 UTC 2021
Withholding of M-CSF Supplement Reprograms Macrophages to M2-Like via Endogenous CSF-1 Activation.
International journal of molecular sciences
Chen YC,Lai YS,Hsuuw YD,Chang KT
315-02 was used in Cell Culture to investigate the effects of M-CSF expression on bone marrow derived macrophages.
Mon Mar 29 00:00:00 UTC 2021
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.
Nature communications
Deng C,Zhang Q,He P,Zhou B,He K,Sun X,Lei G,Gong T,Zhang Z
Mon Apr 12 00:00:00 UTC 2021
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Immunity
Friščić J,Böttcher M,Reinwald C,Bruns H,Wirth B,Popp SJ,Walker KI,Ackermann JA,Chen X,Turner J,Zhu H,Seyler L,Euler M,Kirchner P,Krüger R,Ekici AB,Major T,Aust O,Weidner D,Fischer A,Andes FT,Stanojevic Z,Trajkovic V,Herrmann M,Korb-Pap A,Wank I,Hess A,Winter J,Wixler V,Distler J,Steiner G,Kiener HP,Frey B,Kling L,Raza K,Frey S,Kleyer A,Bäuerle T,Hughes TR,Grüneboom A,Steffen U,Krönke G,Croft AP,Filer A,Köhl J,Klein K,Buckley CD,Schett G,Mougiakakos D,Hoffmann MH
315-02 was used in Cell Culture to define the molecular and cellular mechanisms of this inflammation-mediated tissue priming and suggest possibilities for therapeutic intervention abrogating tissue priming without immunosuppression.
Tue May 11 00:00:00 UTC 2021
Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.
Cell reports
Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C
Tue Jan 12 00:00:00 UTC 2021
Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatability.
Wellcome open research
Hore ZL,Villa-Hernandez S,Denk F
315-02 was used in Cell Culture to investigate chemotherapy-induced peripheral neuropathy and immune contributions.
Tue Apr 02 00:00:00 UTC 2024
Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway.
Cell death discovery
Mukai T,Di Martino E,Tsuji S,Blomgren K,Nagamura-Inoue T,Ådén U
Mon Mar 15 00:00:00 UTC 2021
Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.
Nature communications
Wu K,Feng J,Lyu F,Xing F,Sharma S,Liu Y,Wu SY,Zhao D,Tyagi A,Deshpande RP,Pei X,Ruiz MG,Takahashi H,Tsuzuki S,Kimura T,Mo YY,Shiozawa Y,Singh R,Watabe K
Tue Aug 31 00:00:00 UTC 2021
Monocyte progenitors give rise to multinucleated giant cells.
Nature communications
Lösslein AK,Lohrmann F,Scheuermann L,Gharun K,Neuber J,Kolter J,Forde AJ,Kleimeyer C,Poh YY,Mack M,Triantafyllopoulou A,Dunlap MD,Khader SA,Seidl M,Hölscher A,Hölscher C,Guan XL,Dorhoi A,Henneke P
Thu Apr 01 00:00:00 UTC 2021
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Nature communications
Garcia LR,Tenev T,Newman R,Haich RO,Liccardi G,John SW,Annibaldi A,Yu L,Pardo M,Young SN,Fitzgibbon C,Fernando W,Guppy N,Kim H,Liang LY,Lucet IS,Kueh A,Roxanis I,Gazinska P,Sims M,Smyth T,Ward G,Bertin J,Beal AM,Geddes B,Choudhary JS,Murphy JM,Aurelia Ball K,Upton JW,Meier P
Mon Jun 07 00:00:00 UTC 2021
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
iScience
AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB
Fri Jun 25 00:00:00 UTC 2021
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.
Nature communications
Xu B,Tian L,Chen J,Wang J,Ma R,Dong W,Li A,Zhang J,Antonio Chiocca E,Kaur B,Feng M,Caligiuri MA,Yu J
Fri Oct 08 00:00:00 UTC 2021
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Science advances
Brelstaff JH,Mason M,Katsinelos T,McEwan WA,Ghetti B,Tolkovsky AM,Spillantini MG
315-02 was used in Cell Culture to show that after phagocytosing tau aggregate-bearing neurons, microglia become hypophagocytic while releasing seed-competent insoluble tau aggregates.
Fri Oct 22 00:00:00 UTC 2021
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.
Nature communications
Shi H,Sun L,Wang Y,Liu A,Zhan X,Li X,Tang M,Anderton P,Hildebrand S,Quan J,Ludwig S,Moresco EMY,Beutler B
Tue Mar 02 00:00:00 UTC 2021
Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
Aging
Zhang H,Wang A,Shen G,Wang X,Liu G,Yang F,Chen B,Wang M,Xu Y
315-02 was used in Tissue/organ culture to conclude that hepcidin could provide new targets for the clinical treatment of postmenopausal osteoporosis.
Sun Apr 04 00:00:00 UTC 2021
A flow cytometry approach reveals heterogeneity in conventional subsets of murine renal mononuclear phagocytes.
Scientific reports
Nordlohne J,Hulsmann I,Schwafertz S,Zgrajek J,Grundmann M,von Vietinghoff S,Eitner F,Becker MS
Thu Jun 24 00:00:00 UTC 2021
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice.
Scientific reports
Westermann LM,Baranowsky A,Di Lorenzo G,Danyukova T,Soul J,Schwartz JM,Hendrickx G,Amling M,Rose-John S,Garbers C,Schinke T,Pohl S
Thu Feb 11 00:00:00 UTC 2021
Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Theranostics
Wang X,Mao J,Zhou T,Chen X,Tu H,Ma J,Li Y,Ding Y,Yang Y,Wu H,Tang X
315-02 was used in Cell Culture to study whether myeloid derived growth factor (MYDGF) could accelerate the progression of hepatocellular carcinoma (HCC) and how it works to show that MYDGF could directly affect the self-renewal of liver cells, and indirectly aggravate the inflammatory microenvironment to accelerate the progression of HCC.
Thu Aug 05 00:00:00 UTC 2021
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
iScience
Gomez-Diaz C,Jonsson G,Schodl K,Deszcz L,Bestehorn A,Eislmayr K,Almagro J,Kavirayani A,Seida M,Fennell LM,Hagelkruys A,Kovarik P,Penninger JM,Ikeda F
Fri Nov 19 00:00:00 UTC 2021
A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells.
iScience
Kanemaru H,Mizukami Y,Kaneko A,Tagawa H,Kimura T,Kuriyama H,Sawamura S,Kajihara I,Makino K,Miyashita A,Aoi J,Makino T,Masuguchi S,Fukushima S,Ihn H
Fri Sep 24 00:00:00 UTC 2021
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome.
Nature communications
Wang LQ,Liu T,Yang S,Sun L,Zhao ZY,Li LY,She YC,Zheng YY,Ye XY,Bao Q,Dong GH,Li CW,Cui J
Tue May 18 00:00:00 UTC 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
Wed Jul 14 00:00:00 UTC 2021
Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
Nature communications
Lin CC,Shen YR,Chang CC,Guo XY,Young YY,Lai TY,Yu IS,Lee CY,Chuang TH,Tsai HY,Hsu LC
Tue Jun 29 00:00:00 UTC 2021
Generation of a chemical genetic model for JAK3.
Scientific reports
Remenyi J,Naik RJ,Wang J,Razsolkov M,Verano A,Cai Q,Tan L,Toth R,Raggett S,Baillie C,Traynor R,Hastie CJ,Gray NS,Arthur JSC
Wed May 12 00:00:00 UTC 2021
Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis.
iScience
Ebata T,Terkawi MA,Hamasaki M,Matsumae G,Onodera T,Aly MK,Yokota S,Alhasan H,Shimizu T,Takahashi D,Homan K,Kadoya K,Iwasaki N
Fri Jun 25 00:00:00 UTC 2021
Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging.
Cell death discovery
Liu R,Cui J,Sun Y,Xu W,Wang Z,Wu M,Dong H,Yang C,Hong S,Yin S,Wang H
Mon Dec 20 00:00:00 UTC 2021
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Nature communications
Wang J,Wang J,Hong W,Zhang L,Song L,Shi Q,Shao Y,Hao G,Fang C,Qiu Y,Yang L,Yang Z,Wang J,Cao J,Yang B,He Q,Weng Q
Wed Oct 27 00:00:00 UTC 2021
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation.
Nature communications
Tomlinson KL,Lung TWF,Dach F,Annavajhala MK,Gabryszewski SJ,Groves RA,Drikic M,Francoeur NJ,Sridhar SH,Smith ML,Khanal S,Britto CJ,Sebra R,Lewis I,Uhlemann AC,Kahl BC,Prince AS,Riquelme SA
Wed Mar 03 00:00:00 UTC 2021
Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis.
NPJ Regenerative medicine
Takeuchi S,Tsuchiya A,Iwasawa T,Nojiri S,Watanabe T,Ogawa M,Yoshida T,Fujiki K,Koui Y,Kido T,Yoshioka Y,Fujita M,Kikuta J,Itoh T,Takamura M,Shirahige K,Ishii M,Ochiya T,Miyajima A,Terai S
Tue Mar 30 00:00:00 UTC 2021
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages.
Cell death & disease
Lindhorst A,Raulien N,Wieghofer P,Eilers J,Rossi FMV,Bechmann I,Gericke M
Sat Jun 05 00:00:00 UTC 2021
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation.
Nature communications
Jones N,Blagih J,Zani F,Rees A,Hill DG,Jenkins BJ,Bull CJ,Moreira D,Bantan AIM,Cronin JG,Avancini D,Jones GW,Finlay DK,Vousden KH,Vincent EE,Thornton CA
Mon Feb 22 00:00:00 UTC 2021
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice.
Communications biology
Voisin M,Shrestha E,Rollet C,Nikain CA,Josefs T,Mahé M,Barrett TJ,Chang HR,Ruoff R,Schneider JA,Garabedian ML,Zoumadakis C,Yun C,Badwan B,Brown EJ,Mar AC,Schneider RJ,Goldberg IJ,Pineda-Torra I,Fisher EA,Garabedian MJ
Fri Mar 26 00:00:00 UTC 2021
Subversion of Host Innate Immunity by Rickettsia australis via a Modified Autophagic Response in Macrophages.
Frontiers in immunology
Bechelli J,Rumfield CS,Walker DH,Widen S,Khanipov K,Fang R
315-02 was used in Sample Preparation (FC/FACS) to investigate Atg5-dependent autophagy following R. australis infection.
Thu Oct 28 00:00:00 UTC 2021
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools.
The Journal of biological chemistry
Morgan PK,Huynh K,Pernes G,Miotto PM,Mellett NA,Giles C,Meikle PJ,Murphy AJ,Lancaster GI
Wed Dec 01 00:00:00 UTC 2021
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages.
Nature communications
Wang Y,Tang B,Long L,Luo P,Xiang W,Li X,Wang H,Jiang Q,Tan X,Luo S,Li H,Wang Z,Chen Z,Leng Y,Jiang Z,Wang Y,Ma L,Wang R,Zeng C,Liu Z,Wang Y,Miao H,Shi C
Mon Jan 04 00:00:00 UTC 2021
Itaconate confers tolerance to late NLRP3 inflammasome activation.
Cell reports
Bambouskova M,Potuckova L,Paulenda T,Kerndl M,Mogilenko DA,Lizotte K,Swain A,Hayes S,Sheldon RD,Kim H,Kapadnis U,Ellis AE,Isaguirre C,Burdess S,Laha A,Amarasinghe GK,Chubukov V,Roddy TP,Diamond MS,Jones RG,Simons DM,Artyomov MN
Tue Mar 09 00:00:00 UTC 2021
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Nature communications
Bian Z,Shi L,Kidder K,Zen K,Garnett-Benson C,Liu Y
Fri May 28 00:00:00 UTC 2021
Deletion of fatty acid amide hydrolase reduces lyso-sulfatide levels but exacerbates metachromatic leukodystrophy in mice.
The Journal of biological chemistry
Yaghootfam C,Gehrig B,Sylvester M,Gieselmann V,Matzner U
Wed Sep 01 00:00:00 UTC 2021
The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9.
Cell death & disease
Tong Y,Yu Z,Chen Z,Zhang R,Ding X,Yang X,Niu X,Li M,Zhang L,Billiar TR,Pitt BR,Li Q
Mon Jan 11 00:00:00 UTC 2021
A functional motif of long noncoding RNA Nron against osteoporosis.
Nature communications
Jin F,Li J,Zhang YB,Liu X,Cai M,Liu M,Li M,Ma C,Yue R,Zhu Y,Lai R,Wang Z,Ji X,Wei H,Dong J,Liu Z,Wang Y,Sun Y,Wang X
Thu Jun 03 00:00:00 UTC 2021
A functional motif of long noncoding RNA Nron against osteoporosis.
Nature communications
Jin F,Li J,Zhang YB,Liu X,Cai M,Liu M,Li M,Ma C,Yue R,Zhu Y,Lai R,Wang Z,Ji X,Wei H,Dong J,Liu Z,Wang Y,Sun Y,Wang X
Thu Jun 03 00:00:00 UTC 2021
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.
Journal of extracellular vesicles
Yu L,Sui B,Fan W,Lei L,Zhou L,Yang L,Diao Y,Zhang Y,Li Z,Liu J,Hao X
Fri Jan 01 00:00:00 UTC 2021
Development of Exhausted Memory Monocytes and Underlying Mechanisms.
Frontiers in immunology
Pradhan K,Yi Z,Geng S,Li L
315-02 was used in Cell Culture to reveal that STAT1 is robustly elevated and sustained in LPS-exhausted monocytes, dependent upon the TRAM adaptor of the TLR4 pathway.
Wed Feb 16 00:00:00 UTC 2022
The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein.
Scientific reports
Yusuf B,Mukovozov I,Patel S,Huang YW,Liu GY,Reddy EC,Skrtic M,Glogauer M,Robinson LA
Thu Feb 11 00:00:00 UTC 2021
ABCC6 deficiency promotes dyslipidemia and atherosclerosis.
Scientific reports
Brampton C,Pomozi V,Chen LH,Apana A,McCurdy S,Zoll J,Boisvert WA,Lambert G,Henrion D,Blanchard S,Kuo S,Leftheriotis G,Martin L,Le Saux O
Tue Feb 16 00:00:00 UTC 2021
Repurposing the anthelmintic praziquantel to treat psoriasis.
British journal of pharmacology
Hao L,Mao Y,Park J,Bae EJ,Park BH
315-02 was used in Cell Culture to provide the first preclinical evidence that praziquantel may effectively treat psoriasis, and suggest that praziquantel alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.
Wed Dec 01 00:00:00 UTC 2021
Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Xu S,Li S,Liu X,Tan K,Zhang J,Li K,Bai X,Zhang Y
315-02 was used in In vitro experiments to establish an innovative link between Rictor, TRAF protein levels, and autophagic block.
Fri Oct 01 00:00:00 UTC 2021
Transferrable protection by gut microbes against STING-associated lung disease.
Cell reports
Platt DJ,Lawrence D,Rodgers R,Schriefer L,Qian W,Miner CA,Menos AM,Kennedy EA,Peterson ST,Stinson WA,Baldridge MT,Miner JJ
Tue May 11 00:00:00 UTC 2021
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Nature medicine
Cerezo-Wallis D,Contreras-Alcalde M,Troulé K,Catena X,Mucientes C,Calvo TG,Cañón E,Tejedo C,Pennacchi PC,Hogan S,Kölblinger P,Tejero H,Chen AX,Ibarz N,Graña-Castro O,Martinez L,Muñoz J,Ortiz-Romero P,Rodriguez-Peralto JL,Gómez-López G,Al-Shahrour F,Rabadán R,Levesque MP,Olmeda D,Soengas MS
Tue Dec 01 00:00:00 UTC 2020
Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development.
Cell
Utz SG,See P,Mildenberger W,Thion MS,Silvin A,Lutz M,Ingelfinger F,Rayan NA,Lelios I,Buttgereit A,Asano K,Prabhakar S,Garel S,Becher B,Ginhoux F,Greter M
Thu Apr 30 00:00:00 UTC 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
Thu Mar 19 00:00:00 UTC 2020
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 UTC 2020
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.
Immunity
Remmerie A,Martens L,Thoné T,Castoldi A,Seurinck R,Pavie B,Roels J,Vanneste B,De Prijck S,Vanhockerhout M,Binte Abdul Latib M,Devisscher L,Hoorens A,Bonnardel J,Vandamme N,Kremer A,Borghgraef P,Van Vlierberghe H,Lippens S,Pearce E,Saeys Y,Scott CL
Tue Sep 15 00:00:00 UTC 2020
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Immunity
Morrissey MA,Kern N,Vale RD
Tue Aug 18 00:00:00 UTC 2020
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Immunity
Xiao J,Li W,Zheng X,Qi L,Wang H,Zhang C,Wan X,Zheng Y,Zhong R,Zhou X,Lu Y,Li Z,Qiu Y,Liu C,Zhang F,Zhang Y,Xu X,Yang Z,Chen H,Zhai Q,Wei B,Wang H
Tue Jan 14 00:00:00 UTC 2020
Warmth Prevents Bone Loss Through the Gut Microbiota.
Cell metabolism
Chevalier C,Kieser S,Çolakoğlu M,Hadadi N,Brun J,Rigo D,Suárez-Zamorano N,Spiljar M,Fabbiano S,Busse B,Ivanišević J,Macpherson A,Bonnet N,Trajkovski M
315-02 was used in Cell Culture to show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice.
Tue Oct 06 00:00:00 UTC 2020
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization.
Cell metabolism
Zhang J,Muri J,Fitzgerald G,Gorski T,Gianni-Barrera R,Masschelein E,D'Hulst G,Gilardoni P,Turiel G,Fan Z,Wang T,Planque M,Carmeliet P,Pellerin L,Wolfrum C,Fendt SM,Banfi A,Stockmann C,Soro-Arnáiz I,Kopf M,De Bock K
315-02 was used in Cell Culture to conclude that ECs exploit glycolysis for angiocrine lactate shuttling to steer muscle regeneration from ischemia.
Tue Jun 02 00:00:00 UTC 2020
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.
Nature cell biology
Sheikh BN,Guhathakurta S,Tsang TH,Schwabenland M,Renschler G,Herquel B,Bhardwaj V,Holz H,Stehle T,Bondareva O,Aizarani N,Mossad O,Kretz O,Reichardt W,Chatterjee A,Braun LJ,Thevenon J,Sartelet H,Blank T,Grün D,von Elverfeldt D,Huber TB,Vestweber D,Avilov S,Prinz M,Buescher JM,Akhtar A
315-02 was used in Cell Culture to establish that neurovascular function is determined by the neural metabolic environment.
Wed Jul 01 00:00:00 UTC 2020
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.
The Journal of clinical investigation
Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A
Tue Sep 01 00:00:00 UTC 2020
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
Nucleic acids research
Escoter-Torres L,Greulich F,Quagliarini F,Wierer M,Uhlenhaut NH
315-02 was used in Sample Preparation (PCR) to investigate glucocorticoid receptor in anti-inflammatory effects.
Fri Sep 04 00:00:00 UTC 2020
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
The Journal of experimental medicine
Wang S,Mustafa M,Yuede CM,Salazar SV,Kong P,Long H,Ward M,Siddiqui O,Paul R,Gilfillan S,Ibrahim A,Rhinn H,Tassi I,Rosenthal A,Schwabe T,Colonna M
Mon Sep 07 00:00:00 UTC 2020
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
The Journal of experimental medicine
Cai Z,Zhang MX,Tang Z,Zhang Q,Ye J,Xiong TC,Zhang ZD,Zhong B
Mon May 04 00:00:00 UTC 2020
Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling.
Arthritis & rheumatology (Hoboken, N.J.)
Ishiguro N,Moriyama M,Furusho K,Furukawa S,Shibata T,Murakami Y,Chinju A,Haque ASMR,Gion Y,Ohta M,Maehara T,Tanaka A,Yamauchi M,Sakamoto M,Mochizuki K,Ono Y,Hayashida JN,Sato Y,Kiyoshima T,Yamamoto H,Miyake K,Nakamura S
Wed Jan 01 00:00:00 UTC 2020
Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
EMBO molecular medicine
Szymańska E,Nowak P,Kolmus K,Cybulska M,Goryca K,Derezińska-Wołek E,Szumera-Ciećkiewicz A,Brewińska-Olchowik M,Grochowska A,Piwocka K,Prochorec-Sobieszek M,Mikula M,Miączyńska M
Fri Feb 07 00:00:00 UTC 2020
Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3.
Experimental & molecular medicine
Kim SJ,Jeong YT,Jeong SR,Park M,Go HS,Kim MY,Seong JK,Kim KW,Seo JT,Kim CH,Lee JH,Moon SJ
Fri May 01 00:00:00 UTC 2020
IL10 deficiency promotes alveolar enlargement and lymphoid dysmorphogenesis in the aged murine lung.
Aging cell
Malinina A,Dikeman D,Westbrook R,Moats M,Gidner S,Poonyagariyagorn H,Walston J,Neptune ER
Wed Apr 01 00:00:00 UTC 2020
Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms.
Hypertension (Dallas, Tex. : 1979)
Liu CL,Liu X,Wang Y,Deng Z,Liu T,Sukhova GK,Wojtkiewicz GR,Tang R,Zhang JY,Achilefu S,Nahrendorf M,Libby P,Wang X,Shi GP
315-02 was used in Cell Culture to establish a direct role of Nhe1 in AAA pathogenesis.
Wed Jul 01 00:00:00 UTC 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 UTC 2020
Ophiopogonin D promotes bone regeneration by stimulating CD31hi EMCNhi vessel formation.
Cell proliferation
Yang M,Li CJ,Xiao Y,Guo Q,Huang Y,Su T,Luo XH,Jiang TJ
Sun Mar 01 00:00:00 UTC 2020
Oestrogen-activated autophagy has a negative effect on the anti-osteoclastogenic function of oestrogen.
Cell proliferation
Cheng L,Zhu Y,Ke D,Xie D
Wed Apr 01 00:00:00 UTC 2020
A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia.
Cell proliferation
Yan K,Wu C,Ye Y,Li L,Wang X,He W,Ren S,Xu Y
Sun Mar 01 00:00:00 UTC 2020
Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia.
Glia
Pannell M,Economopoulos V,Wilson TC,Kersemans V,Isenegger PG,Larkin JR,Smart S,Gilchrist S,Gouverneur V,Sibson NR
Sat Feb 01 00:00:00 UTC 2020
A transcriptional toolbox for exploring peripheral neuroimmune interactions.
Pain
Liang Z,Hore Z,Harley P,Uchenna Stanley F,Michrowska A,Dahiya M,La Russa F,Jager SE,Villa-Hernandez S,Denk F
315-02 was used in Cell Culture to investigate communication between immune cells and peripheral neurones in pain.
Tue Sep 01 00:00:00 UTC 2020
Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.
Immunology
Wilson TJ,Clare S,Mikulin J,Johnson CM,Harcourt K,Lyons PA,Dougan G,Smith KGC
Wed Apr 01 00:00:00 UTC 2020
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation.
Journal of lipid research
Kumar A,Gupta P,Rana M,Chandra T,Dikshit M,Barthwal MK
Sun Mar 01 00:00:00 UTC 2020
Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Suresh S,Lee J,Noguchi CT
Tue Sep 01 00:00:00 UTC 2020
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wu Y,Wu B,Zhang Z,Lu H,Fan C,Qi Q,Gao Y,Li H,Feng C,Zuo J,Tang W
Mon Jun 01 00:00:00 UTC 2020
D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ganesan R,Henkels KM,Shah K,De La Rosa X,Libreros S,Cheemarla NR,Serhan CN,Gomez-Cambronero J
Tue Dec 01 00:00:00 UTC 2020
Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang Y,Yang X,Yan W,Li R,Ye Q,You L,Xie W,Mo K,Fu R,Wang Y,Chen Y,Hou H,Yang Y,Birnbaumer L,Di Q,Li X
Tue Sep 01 00:00:00 UTC 2020
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huang M,Wang Q,Long F,Di Y,Wang J,Zhun Zhu Y,Liu X
Sun Mar 01 00:00:00 UTC 2020
Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inoue K,Hu X,Zhao B
Sat Feb 01 00:00:00 UTC 2020
Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Song C,Cao J,Lei Y,Chi H,Kong P,Chen G,Yu T,Li J,Kumar Prajapati R,Xia J,Yan J
Sun Mar 01 00:00:00 UTC 2020
Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shi Y,Wang H,Zheng M,Xu W,Yang Y,Shi F
Wed Jan 01 00:00:00 UTC 2020
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zheng W,Ding B,Li X,Liu D,Yokota H,Zhang P
Sat Feb 01 00:00:00 UTC 2020
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zheng W,Ding B,Li X,Liu D,Yokota H,Zhang P
Sat Feb 01 00:00:00 UTC 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 UTC 2020
Porphyromonas gingivalis Promotes Immunoevasion of Oral Cancer by Protecting Cancer from Macrophage Attack.
Journal of immunology (Baltimore, Md. : 1950)
Liu S,Zhou X,Peng X,Li M,Ren B,Cheng G,Cheng L
Wed Jul 01 00:00:00 UTC 2020
TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching.
Journal of immunology (Baltimore, Md. : 1950)
Scheraga RG,Abraham S,Grove LM,Southern BD,Crish JF,Perelas A,McDonald C,Asosingh K,Hasday JD,Olman MA
Sun Mar 01 00:00:00 UTC 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 UTC 2020
Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production.
Journal of immunology (Baltimore, Md. : 1950)
Lentini G,Famà A,Biondo C,Mohammadi N,Galbo R,Mancuso G,Iannello D,Zummo S,Giardina M,De Gaetano GV,Teti G,Beninati C,Midiri A
Sat Feb 01 00:00:00 UTC 2020
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Miki H,Han KH,Scott D,Croft M,Kang YJ
Wed Apr 01 00:00:00 UTC 2020
Mouse 4T1 Breast Cancer Cell-Derived Exosomes Induce Proinflammatory Cytokine Production in Macrophages via miR-183.
Journal of immunology (Baltimore, Md. : 1950)
Guo J,Duan Z,Zhang C,Wang W,He H,Liu Y,Wu P,Wang S,Song M,Chen H,Chen C,Si Q,Xiang R,Luo Y
Sun Nov 15 00:00:00 UTC 2020
Glycyrrhizin Protects γ-Irradiated Mice from Gut Bacteria-Associated Infectious Complications by Improving miR-222-Associated Gas5 RNA Reduction in Macrophages of the Bacterial Translocation Site.
Journal of immunology (Baltimore, Md. : 1950)
Ito I,Loucas BD,Suzuki S,Kobayashi M,Suzuki F
Sun Mar 01 00:00:00 UTC 2020
Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Korn MA,Schmitt H,Angermüller S,Chambers D,Seeling M,Lux UT,Brey S,Royzman D,Brückner C,Popp V,Percivalle E,Bäuerle T,Zinser E,Winkler TH,Steinkasserer A,Nimmerjahn F,Nitschke L
Sun Nov 15 00:00:00 UTC 2020
CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Campuzano A,Zhang H,Ostroff GR,Dos Santos Dias L,Wüthrich M,Klein BS,Yu JJ,Lara HH,Lopez-Ribot JL,Hung CY
Mon Jun 15 00:00:00 UTC 2020
4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response.
Journal of immunology (Baltimore, Md. : 1950)
Pearl D,Katsumura S,Amiri M,Tabatabaei N,Zhang X,Vinette V,Pang X,Beug ST,Kim SH,Jones LM,Robichaud N,Ong SG,Jia JJ,Ali H,Tremblay ML,Jaramillo M,Alain T,Morita M,Sonenberg N,Tahmasebi S
Fri May 01 00:00:00 UTC 2020
Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Jeong YH,Walsh MC,Yu J,Shen H,Wherry EJ,Choi Y
Sat Aug 01 00:00:00 UTC 2020
Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer.
Journal of cellular and molecular medicine
Cui L,Yang G,Ye J,Yao Y,Lu G,Chen J,Fang L,Lu S,Zhou J
Sat Aug 01 00:00:00 UTC 2020
Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Journal of cellular and molecular medicine
Wang J,Guan H,Liu H,Lei Z,Kang H,Guo Q,Dong Y,Liu H,Sun Y,Fang Z,Li F
Sat Feb 01 00:00:00 UTC 2020
CSF-1R inhibition disrupts the dialog between leukaemia cells and macrophages and delays leukaemia progression.
Journal of cellular and molecular medicine
Li K,Xu W,Lu K,Wen Y,Xin T,Shen Y,Lv X,Hu S,Jin R,Wu X
Sun Nov 01 00:00:00 UTC 2020
CSF-1R inhibition disrupts the dialog between leukaemia cells and macrophages and delays leukaemia progression.
Journal of cellular and molecular medicine
Li K,Xu W,Lu K,Wen Y,Xin T,Shen Y,Lv X,Hu S,Jin R,Wu X
Sun Nov 01 00:00:00 UTC 2020
Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Journal of cellular and molecular medicine
Pang C,Wen L,Qin H,Zhu B,Lu X,Luo S
Sat Aug 01 00:00:00 UTC 2020
Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Journal of cellular and molecular medicine
Zhao P,Zhou W,Zhang Y,Li J,Zhao Y,Pan L,Shen Z,Chen W,Hui J
Sat Feb 01 00:00:00 UTC 2020
P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity.
Journal of cell science
Savio LEB,de Andrade Mello P,Santos SACS,de Sousa JC,Oliveira SDS,Minshall RD,Kurtenbach E,Wu Y,Longhi MS,Robson SC,Coutinho-Silva R
315-02 was used in Cell Culture to study the triggering receptor that initiates lipid raft-dependent.
Fri Mar 06 00:00:00 UTC 2020
Metformin shows anti-inflammatory effects in murine macrophages through Dicer/microribonucleic acid-34a-5p and microribonucleic acid-125b-5p.
Journal of diabetes investigation
Luo X,Hu R,Zheng Y,Liu S,Zhou Z
Wed Jan 01 00:00:00 UTC 2020
Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance.
Cells
Mendoza-Reinoso V,Baek DY,Kurutz A,Rubin JR,Koh AJ,McCauley LK,Roca H
315-02 was used in Cell Culture to investigate effects of efferocytosis of cancer in its progression.
Wed Feb 12 00:00:00 UTC 2020
Deficiency of Calcitonin Gene-Related Peptide Affects Macrophage Polarization in Osseointegration.
Frontiers in physiology
Yuan Y,Jiang Y,Wang B,Guo Y,Gong P,Xiang L
315-02 was used in Sample Preparation (FC/FACS) to study the effect of calcitonin gene-related peptide-α (CGRP) on macrophage polarization in titanium osseointegration.
Mon Sep 28 00:00:00 UTC 2020
SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.
Nature communications
Bhosle VK,Mukherjee T,Huang YW,Patel S,Pang BWF,Liu GY,Glogauer M,Wu JY,Philpott DJ,Grinstein S,Robinson LA
Mon Aug 17 00:00:00 UTC 2020
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
The Journal of biological chemistry
Weskamp G,Tüshaus J,Li D,Feederle R,Maretzky T,Swendemann S,Falck-Pedersen E,McIlwain DR,Mak TW,Salmon JE,Lichtenthaler SF,Blobel CP
Fri Mar 27 00:00:00 UTC 2020
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
eLife
Alonso-Herranz L,Sahún-Español Á,Paredes A,Gonzalo P,Gkontra P,Núñez V,Clemente C,Cedenilla M,Villalba-Orero M,Inserte J,García-Dorado D,Arroyo AG,Ricote M
315-02 was used in Cell Culture to indicate the contribution of EndMT to cardiac fibrosis and adverse remodeling post-MI and identify Mφ MT1-MMP as a key regulator of this process.
Fri Oct 16 00:00:00 UTC 2020
Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis.
Cell death & disease
Xu F,Ma Y,Huang W,Gao J,Guo M,Li J,Kong L,Liang G,Du R,Xu Q,Wu X
Thu Aug 20 00:00:00 UTC 2020
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis.
Scientific reports
Rocha FRG,Delitto AE,de Souza JAC,González-Maldonado LA,Wallet SM,Rossa Junior C
Fri May 08 00:00:00 UTC 2020
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.
Nature communications
Gonçalves SM,Duarte-Oliveira C,Campos CF,Aimanianda V,Ter Horst R,Leite L,Mercier T,Pereira P,Fernández-García M,Antunes D,Rodrigues CS,Barbosa-Matos C,Gaifem J,Mesquita I,Marques A,Osório NS,Torrado E,Rodrigues F,Costa S,Joosten LA,Lagrou K,Maertens J,Lacerda JF,Campos A,Brown GD,Brakhage AA,Barbas C,Silvestre R,van de Veerdonk FL,Chamilos G,Netea MG,Latgé JP,Cunha C,Carvalho A
Fri May 08 00:00:00 UTC 2020
Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin.
Frontiers in immunology
Rahtes A,Li L
315-02 was used in Cell Culture to show bacterial endotoxin exposure at low levels can result in murine monocyte accumulation of Nrf2-inhibitory protein Keap1.
Mon Apr 19 00:00:00 UTC 2021
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.
The Journal of biological chemistry
Liu W,Yin Y,Wang M,Fan T,Zhu Y,Shen L,Peng S,Gao J,Deng G,Meng X,Kong L,Feng GS,Guo W,Xu Q,Sun Y
Fri Jul 31 00:00:00 UTC 2020
ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP.
The Journal of biological chemistry
Cao DY,Spivia WR,Veiras LC,Khan Z,Peng Z,Jones AE,Bernstein EA,Saito S,Okwan-Duodu D,Parker SJ,Giani JF,Divakaruni AS,Van Eyk JE,Bernstein KE
Fri Jan 31 00:00:00 UTC 2020
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.
Nature communications
Luthria G,Li R,Wang S,Prytyskach M,Kohler RH,Lauffenburger DA,Mitchison TJ,Weissleder R,Miller MA
Tue Jul 14 00:00:00 UTC 2020
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Nature communications
Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B
Tue Apr 14 00:00:00 UTC 2020
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Redox biology
Xu F,Guo M,Huang W,Feng L,Zhu J,Luo K,Gao J,Zheng B,Kong LD,Pang T,Wu X,Xu Q
315-02 was used in In vitro experiments to associate Annexin A5 with the special effect on hepatic macrophage phenotype shift from M1 to M2.
Tue Sep 01 00:00:00 UTC 2020
Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis.
FEBS open bio
Jiao Y,Chen C,Hu X,Feng X,Shi Z,Cao J,Li Q,Zhu Y
Sat Aug 01 00:00:00 UTC 2020
Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis.
eLife
Deng Z,Ng C,Inoue K,Chen Z,Xia Y,Hu X,Greenblatt M,Pernis A,Zhao B
315-02 was used in Cell Culture to investigate Def6 regulation in osteoblastic bone remodelling.
Tue Dec 29 00:00:00 UTC 2020
Indirect regulation of HMGB1 release by gasdermin D.
Nature communications
Volchuk A,Ye A,Chi L,Steinberg BE,Goldenberg NM
Fri Sep 11 00:00:00 UTC 2020
Triacylglycerol synthesis enhances macrophage inflammatory function.
Nature communications
Castoldi A,Monteiro LB,van Teijlingen Bakker N,Sanin DE,Rana N,Corrado M,Cameron AM,Hässler F,Matsushita M,Caputa G,Klein Geltink RI,Büscher J,Edwards-Hicks J,Pearce EL,Pearce EJ
Fri Aug 14 00:00:00 UTC 2020
CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway.
Cell death & disease
Kim JW,Oh SH,Lee MN,Song JH,Jeong BC,Yang JW,Piao X,Zang Y,Ryu JH,Koh JT
Mon May 11 00:00:00 UTC 2020
High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation.
Nature communications
He W,Xu J,Mu R,Li Q,Lv DL,Huang Z,Zhang J,Wang C,Dong L
Tue Apr 07 00:00:00 UTC 2020
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer.
Cell reports
Kwak T,Wang F,Deng H,Condamine T,Kumar V,Perego M,Kossenkov A,Montaner LJ,Xu X,Xu W,Zheng C,Schuchter LM,Amaravadi RK,Mitchell TC,Karakousis GC,Mulligan C,Nam B,Masters G,Hockstein N,Bennett J,Nefedova Y,Gabrilovich DI
315-02 was used in In vitro experiments to reveal the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.
Tue Dec 29 00:00:00 UTC 2020
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.
Nature communications
Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B
Mon Nov 02 00:00:00 UTC 2020
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Scientific reports
Kang IS,Jang JS,Kim C
Mon Apr 27 00:00:00 UTC 2020
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Cell reports
Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR
315-02 was used in Cell Culture to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.
Tue Jul 07 00:00:00 UTC 2020
Tim‑3 regulates the ability of macrophages to counter lipopolysaccharide‑induced pulmonary epithelial barrier dysfunction via the PI3K/Akt pathway in epithelial cells.
Molecular medicine reports
Zhang Y,Zhang W
315-02 was used in Cell Culture to reveal that co-culture of LPS-treated epithelial MLE-12 cells with M1 macrophages decreased cell migration and promoted permeability, whereas co-culture with M2 macrophages caused the opposite effects.
Wed Jul 01 00:00:00 UTC 2020
Morphine-mediated release of miR-138 in astrocyte-derived extracellular vesicles promotes microglial activation.
Journal of extracellular vesicles
Liao K,Niu F,Hu G,Yang L,Dallon B,Villarreal D,Buch S
Thu Oct 01 00:00:00 UTC 2020
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models.
Nature communications
Lu SW,Pan HC,Hsu YH,Chang KC,Wu LW,Chen WY,Chang MS
Mon Sep 14 00:00:00 UTC 2020
Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis.
Scientific reports
Hamasaki M,Terkawi MA,Onodera T,Tian Y,Ebata T,Matsumae G,Alhasan H,Takahashi D,Iwasaki N
Tue May 05 00:00:00 UTC 2020
Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response.
Nature communications
Yu X,Dai Y,Zhao Y,Qi S,Liu L,Lu L,Luo Q,Zhang Z
Fri Feb 28 00:00:00 UTC 2020
Microbe-Dependent Exacerbated Alveolar Bone Destruction in Heterozygous Cherubism Mice.
JBMR plus
Kittaka M,Yoshimoto T,Schlosser C,Kajiya M,Kurihara H,Reichenberger EJ,Ueki Y
Mon Jun 01 00:00:00 UTC 2020
Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation.
Science advances
Dou G,Tian R,Liu X,Yuan P,Ye Q,Liu J,Liu S,Zhou J,Deng Z,Chen X,Liu S,Jin Y
315-02 was used in Cell Culture to provides strategies to arbitrarily engineer modular EVs that integrate the advantages of natural EVs and synthetic materials for various applications.
Wed Jul 01 00:00:00 UTC 2020
QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism.
Cell death & disease
Du T,Yan Z,Zhu S,Chen G,Wang L,Ye Z,Wang W,Zhu Q,Lu Z,Cao X
Thu May 07 00:00:00 UTC 2020
Effects of IL-34 on Macrophage Immunological Profile in Response to Alzheimer's-Related Aβ42 Assemblies.
Frontiers in immunology
Zuroff LR,Torbati T,Hart NJ,Fuchs DT,Sheyn J,Rentsendorj A,Koronyo Y,Hayden EY,Teplow DB,Black KL,Koronyo-Hamaoui M
315-02 was used in In vitro experiments to indicate that IL-34 impairs monocyte differentiation into macrophages and reduces their ability to uptake pathological formals of Aβ, such as Aβ42 which is highly associated with Alzheimer's disease.
Mon Apr 19 00:00:00 UTC 2021
YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulating NF-κB Activation.
Cancers
Shah A,Plaza-Sirvent C,Weinert S,Buchbinder JH,Lavrik IN,Mertens PR,Schmitz I,Lindquist JA
315-02 was used in In vitro experiments to indicate that YB-1 plays a central role in promoting cell survival through NF-κB activation and identifies a novel mechanism by which enhanced YB-1 expression may contribute to tumor development.
Wed Aug 05 00:00:00 UTC 2020
A Requirement for Argonaute 4 in Mammalian Antiviral Defense.
Cell reports
Adiliaghdam F,Basavappa M,Saunders TL,Harjanto D,Prior JT,Cronkite DA,Papavasiliou N,Jeffrey KL
315-02 was used in Cell Culture to study the antiviral activity of Argonautes AGO1, AGO3 or AGO4 in interferon (IFN)-competent immune cells to demonstrate an essential role for AGO4 in mammalian antiviral defense.
Tue Feb 11 00:00:00 UTC 2020
SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect.
Autophagy
Zhang B,Chen H,Ouyang J,Xie Y,Chen L,Tan Q,Du X,Su N,Ni Z,Chen L
315-02 was used in Cell Culture to show that LIPUS ameliorated synovial inflammation in destabilization of the medial meniscus (DMM) mouse model and air pouch model, and alleviated pain gait patterns of DMM mouse.
Wed Jul 01 00:00:00 UTC 2020
Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model.
Scientific reports
Sulaiman GM,Waheeb HM,Jabir MS,Khazaal SH,Dewir YH,Naidoo Y
Tue Jun 09 00:00:00 UTC 2020
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice.
The Journal of biological chemistry
Cheng N,Liu C,Li Y,Gao S,Han YC,Wang X,Du J,Zhang C
Fri Jul 24 00:00:00 UTC 2020
Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip.
eLife
Muri J,Thut H,Feng Q,Kopf M
315-02 was used in Cell Culture to show that in contrast to its critical role in T cells, the murine Trx1 system is dispensable for steady-state myeloid-cell hematopoiesis due to their capacity to tap the glutathione/glutaredoxin pathway for DNA biosynthesis.
Tue Feb 25 00:00:00 UTC 2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk.
Nature communications
Wang L,You X,Lotinun S,Zhang L,Wu N,Zou W
Wed Jan 15 00:00:00 UTC 2020
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism.
Nature communications
Weivoda MM,Chew CK,Monroe DG,Farr JN,Atkinson EJ,Geske JR,Eckhardt B,Thicke B,Ruan M,Tweed AJ,McCready LK,Rizza RA,Matveyenko A,Kassem M,Andersen TL,Vella A,Drake MT,Clarke BL,Oursler MJ,Khosla S
Tue Jan 07 00:00:00 UTC 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Thu Jul 11 00:00:00 UTC 2019
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells.
Cell
Liu Z,Gu Y,Chakarov S,Bleriot C,Kwok I,Chen X,Shin A,Huang W,Dress RJ,Dutertre CA,Schlitzer A,Chen J,Ng LG,Wang H,Liu Z,Su B,Ginhoux F
Thu Sep 05 00:00:00 UTC 2019
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Cell research
Jacquelot N,Yamazaki T,Roberti MP,Duong CPM,Andrews MC,Verlingue L,Ferrere G,Becharef S,Vétizou M,Daillère R,Messaoudene M,Enot DP,Stoll G,Ugel S,Marigo I,Foong Ngiow S,Marabelle A,Prevost-Blondel A,Gaudreau PO,Gopalakrishnan V,Eggermont AM,Opolon P,Klein C,Madonna G,Ascierto PA,Sucker A,Schadendorf D,Smyth MJ,Soria JC,Kroemer G,Bronte V,Wargo J,Zitvogel L
Tue Oct 01 00:00:00 UTC 2019
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
Immunity
Schulthess J,Pandey S,Capitani M,Rue-Albrecht KC,Arnold I,Franchini F,Chomka A,Ilott NE,Johnston DGW,Pires E,McCullagh J,Sansom SN,Arancibia-Cárcamo CV,Uhlig HH,Powrie F
Tue Feb 19 00:00:00 UTC 2019
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Immunity
Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR
Tue Apr 16 00:00:00 UTC 2019
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Immunity
Daniels BP,Kofman SB,Smith JR,Norris GT,Snyder AG,Kolb JP,Gao X,Locasale JW,Martinez J,Gale M,Loo YM,Oberst A
Tue Jan 15 00:00:00 UTC 2019
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Cell metabolism
Puleston DJ,Buck MD,Klein Geltink RI,Kyle RL,Caputa G,O'Sullivan D,Cameron AM,Castoldi A,Musa Y,Kabat AM,Zhang Y,Flachsmann LJ,Field CS,Patterson AE,Scherer S,Alfei F,Baixauli F,Austin SK,Kelly B,Matsushita M,Curtis JD,Grzes KM,Villa M,Corrado M,Sanin DE,Qiu J,Pällman N,Paz K,Maccari ME,Blazar BR,Mittler G,Buescher JM,Zehn D,Rospert S,Pearce EJ,Balabanov S,Pearce EL
315-02 was used in Cell Culture to show that these results might have implications for therapeutically controlling macrophage activation by targeting the polyamine-eIF5A-hypusine axis.
Tue Aug 06 00:00:00 UTC 2019
Low-dose chidamide restores immune tolerance in ITP in mice and humans.
Blood
Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M
Thu Feb 14 00:00:00 UTC 2019
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance.
The Journal of clinical investigation
Muraoka D,Seo N,Hayashi T,Tahara Y,Fujii K,Tawara I,Miyahara Y,Okamori K,Yagita H,Imoto S,Yamaguchi R,Komura M,Miyano S,Goto M,Sawada SI,Asai A,Ikeda H,Akiyoshi K,Harada N,Shiku H
Fri Mar 01 00:00:00 UTC 2019
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
The Journal of experimental medicine
Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK
Mon Feb 04 00:00:00 UTC 2019
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.
The Journal of experimental medicine
Mastio J,Condamine T,Dominguez G,Kossenkov AV,Donthireddy L,Veglia F,Lin C,Wang F,Fu S,Zhou J,Viatour P,Lavilla-Alonso S,Polo AT,Tcyganov EN,Mulligan C,Nam B,Bennett J,Masters G,Guarino M,Kumar A,Nefedova Y,Vonderheide RH,Languino LR,Abrams SI,Gabrilovich DI
Mon Sep 02 00:00:00 UTC 2019
Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
The Journal of experimental medicine
Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S
Mon Jun 03 00:00:00 UTC 2019
Krüppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome.
The Journal of experimental medicine
Yang M,Guo Q,Peng H,Xiao YZ,Xiao Y,Huang Y,Li CJ,Su T,Zhang YL,Lei MX,Chen HL,Jiang TJ,Luo XH
Mon Aug 05 00:00:00 UTC 2019
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
The Journal of experimental medicine
von Gamm M,Schaub A,Jones AN,Wolf C,Behrens G,Lichti J,Essig K,Macht A,Pircher J,Ehrlich A,Davari K,Chauhan D,Busch B,Wurst W,Feederle R,Feuchtinger A,Tschöp MH,Friedel CC,Hauck SM,Sattler M,Geerlof A,Hornung V,Heissmeyer V,Schulz C,Heikenwalder M,Glasmacher E
Mon Jul 01 00:00:00 UTC 2019
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.
Autophagy
Rai S,Arasteh M,Jefferson M,Pearson T,Wang Y,Zhang W,Bicsak B,Divekar D,Powell PP,Naumann R,Beraza N,Carding SR,Florey O,Mayer U,Wileman T
315-02 was used in Sample Preparation (FC/FACS) to investigate the roles of LC3 and ATG16L1 in autophagy and phagocytosis.
Mon Apr 01 00:00:00 UTC 2019
Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice.
Bone research
Lee SY,Park KH,Yu HG,Kook E,Song WH,Lee G,Koh JT,Shin HI,Choi JY,Huh YH,Ryu JH
Thu Oct 01 00:00:00 UTC 2020
Erythropoietin modulates bone marrow stromal cell differentiation.
Bone research
Suresh S,de Castro LF,Dey S,Robey PG,Noguchi CT
Wed Sep 30 00:00:00 UTC 2020
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Genes & development
Labi V,Peng S,Klironomos F,Munschauer M,Kastelic N,Chakraborty T,Schoeler K,Derudder E,Martella M,Mastrobuoni G,Hernandez-Miranda LR,Lahmann I,Kocks C,Birchmeier C,Kempa S,Quintanilla-Martinez de Fend L,Landthaler M,Rajewsky N,Rajewsky K
315-02 was used in Cell Culture to conclude that the interaction of miR-17∼92 with a single target is essential for life, and BIM regulation by miRNAs serves as a rheostat controlling cell survival in specific physiological contexts.
Sun Dec 01 00:00:00 UTC 2019
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Wang KW,Zhan X,McAlpine W,Zhang Z,Choi JH,Shi H,Misawa T,Yue T,Zhang D,Wang Y,Ludwig S,Russell J,Tang M,Li X,Murray AR,Moresco EMY,Turer EE,Beutler B
Tue Jun 04 00:00:00 UTC 2019
The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3.
Experimental & molecular medicine
Du RH,Lu M,Wang C,Ding JH,Wu G,Hu G
Tue Aug 06 00:00:00 UTC 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
315-02 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 UTC 2019
Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage.
Mucosal immunology
Lv Z,Wang Z,Luo L,Chen Y,Han G,Wang R,Xiao H,Li X,Hou C,Feng J,Shen B,Wang Y,Peng H,Guo R,Li Y,Chen G
Sun Sep 01 00:00:00 UTC 2019
Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice.
Stem cells translational medicine
Watanabe Y,Tsuchiya A,Seino S,Kawata Y,Kojima Y,Ikarashi S,Starkey Lewis PJ,Lu WY,Kikuta J,Kawai H,Yamagiwa S,Forbes SJ,Ishii M,Terai S
Fri Mar 01 00:00:00 UTC 2019
dPGS Regulates the Phenotype of Macrophages via Metabolic Switching.
Macromolecular bioscience
Wu H,Reimann S,Siddiqui S,Haag R,Siegmund B,Dernedde J,Glauben R
Sun Dec 01 00:00:00 UTC 2019
LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Skon-Hegg C,Zhang J,Wu X,Sagolla M,Ota N,Wuster A,Tom J,Doran E,Ramamoorthi N,Caplazi P,Monroe J,Lee WP,Behrens TW
Tue Jan 01 00:00:00 UTC 2019
Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Liu W,Bai F,Wang H,Liang Y,Du X,Liu C,Cai D,Peng J,Zhong G,Liang X,Ma C,Gao L
315-02 was used in Cell Culture to unveil the novel function of Tim-4 in suppressing NLRP3 inflammasome, which would shed new lights on intervention of NAFLD or inflammatory liver diseases by targeting Tim-4.
Thu Aug 15 00:00:00 UTC 2019
Macrophages Are a Potent Source of Streptococcus-Induced IFN-β.
Journal of immunology (Baltimore, Md. : 1950)
Feuerstein R,Gres V,Elias Perdigó N,Baasch S,Freudenhammer M,Elling R,Henneke P
Sun Dec 15 00:00:00 UTC 2019
Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis.
Journal of cellular and molecular medicine
Zhou F,Mei J,Yuan K,Han X,Qiao H,Tang T
Sat Jun 01 00:00:00 UTC 2019
Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis.
Journal of cellular and molecular medicine
Zhou F,Mei J,Yuan K,Han X,Qiao H,Tang T
Sat Jun 01 00:00:00 UTC 2019
Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis.
Journal of cellular and molecular medicine
Jiang M,Yan Y,Yang K,Liu Z,Qi J,Zhou H,Qian N,Zhou Q,Wang T,Xu X,Xiao X,Deng L
Fri Feb 01 00:00:00 UTC 2019
Resveratrol decreases CD45+ CD206- subtype macrophages in LPS-induced murine acute lung injury by SOCS3 signalling pathway.
Journal of cellular and molecular medicine
Hu L,Chen Z,Li L,Jiang Z,Zhu L
Sun Dec 01 00:00:00 UTC 2019
Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment.
Molecular carcinogenesis
Susen RM,Bauer R,Olesch C,Fuhrmann DC,Fink AF,Dehne N,Jain A,Ebersberger I,Schmid T,Brüne B
Fri Nov 01 00:00:00 UTC 2019
Atg5 Supports Rickettsia australis Infection in Macrophages In Vitro and In Vivo.
Infection and immunity
Bechelli J,Vergara L,Smalley C,Buzhdygan TP,Bender S,Zhang W,Liu Y,Popov VL,Wang J,Garg N,Hwang S,Walker DH,Fang R
315-02 was used in Sample Preparation (FC/FACS) to study how rickettsiae remain free in macrophages prior to establishing their infection in microvascular endothelial cells.
Tue Jan 01 00:00:00 UTC 2019
Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization.
Cell death & disease
Wang F,Sun F,Luo J,Yue T,Chen L,Zhou H,Zhang J,Yang C,Luo X,Zhou Q,Zhu H,Li J,Yang P,Xiong F,Yu Q,Zhang H,Zhang W,Xu A,Zhou Z,Lu Q,Eizirik DL,Zhang S,Wang CY
Tue Nov 26 00:00:00 UTC 2019
The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis.
Nature communications
Doonan J,Tarafdar A,Pineda MA,Lumb FE,Crowe J,Khan AM,Hoskisson PA,Harnett MM,Harnett W
Fri Apr 05 00:00:00 UTC 2019
EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection.
Cell reports
Swidergall M,Solis NV,Wang Z,Phan QT,Marshall ME,Lionakis MS,Pearlman E,Filler SG
315-02 was used in Cell Culture to study the role of Ephrin-type A receptor 2 (EphA2) in neutrophil candidacidal activity during oropharyngeal candidiasis.
Tue Jul 09 00:00:00 UTC 2019
Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.
MicrobiologyOpen
Fultz R,Engevik MA,Shi Z,Hall A,Herrmann B,Ganesh BP,Major A,Haag A,Mori-Akiyama Y,Versalovic J
Tue Oct 01 00:00:00 UTC 2019
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
Nature communications
Wu X,Lei C,Xia T,Zhong X,Yang Q,Shu HB
Wed Sep 11 00:00:00 UTC 2019
Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yang L,Sun J,Liu Q,Zhu R,Yang Q,Hua J,Zheng L,Li K,Wang S,Li A
Wed Apr 17 00:00:00 UTC 2019
CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages.
Cell death & disease
Shin Y,Won Y,Yang JI,Chun JS
Fri Jan 18 00:00:00 UTC 2019
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.
Nature communications
Managò A,Audrito V,Mazzola F,Sorci L,Gaudino F,Gizzi K,Vitale N,Incarnato D,Minazzato G,Ianniello A,Varriale A,D'Auria S,Mengozzi G,Politano G,Oliviero S,Raffaelli N,Deaglio S
Wed Sep 11 00:00:00 UTC 2019
Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition.
Acta neuropathologica communications
Fan RZ,Guo M,Luo S,Cui M,Tieu K
315-02 was used in Cell Culture to investigate potential treatment of Parkinson’s disease by targeting α-synuclein.
Tue Nov 19 00:00:00 UTC 2019
Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway.
The Journal of biological chemistry
Omi M,Kaartinen V,Mishina Y
Fri Nov 22 00:00:00 UTC 2019
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment.
Scientific reports
Kang J,Choi YJ,Seo BY,Jo U,Park SI,Kim YH,Park KH
315-02 was used in Cell Culture to study the efficacy of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) in the bone microenvironment where breast cancer cells most frequently metastasize.
Wed Jun 19 00:00:00 UTC 2019
A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment.
Scientific reports
Kang J,Choi YJ,Seo BY,Jo U,Park SI,Kim YH,Park KH
315-02 was used in Cell Culture to study the efficacy of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors (TKIs) in the bone microenvironment where breast cancer cells most frequently metastasize.
Wed Jun 19 00:00:00 UTC 2019
TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis.
Cell death & disease
Li J,Zhang J,Zhang Y,Wang Z,Song Y,Wei S,He M,You S,Jia J,Cheng J
Mon Apr 15 00:00:00 UTC 2019
VU0155069 inhibits inflammasome activation independent of phospholipase D1 activity.
Scientific reports
Lee SK,Kim YS,Bae GH,Lee HY,Bae YS
Fri Oct 04 00:00:00 UTC 2019
Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment.
Scientific reports
Menzel M,Kosinski J,Uller L,Akbarshahi H
Mon Sep 16 00:00:00 UTC 2019
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.
Frontiers in immunology
Dong L,Wu J,Chen K,Xie J,Wang Y,Li D,Liu Y,Yin A,Zhao Y,Han Y,Zhou J,Zhang L,Chen Z,Zuo D
315-02 was used in Cell Culture to investigate the role of mannan-binding lectin on murine adjuvant-induced arthritis.
Wed Oct 28 00:00:00 UTC 2020
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.
Cell stem cell
Wang ECE,Dai Z,Ferrante AW,Drake CG,Christiano AM
315-02 was used in In vivo experiments to show that Oncostatin M, an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain hair follicle stem cells quiescence.
Thu Apr 04 00:00:00 UTC 2019
Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis.
Scientific reports
Toledo-Flores D,Williamson A,Schwarz N,Fernando S,Dimasi C,Witt TA,Nguyen TM,Puranik AS,Chue CD,Delacroix S,Spoon DB,Bonder CS,Bursill CA,Di Bartolo BA,Nicholls SJ,Simari RD,Psaltis PJ
Mon May 13 00:00:00 UTC 2019
The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.
The Journal of biological chemistry
Francisco J,Byun J,Zhang Y,Kalloo OB,Mizushima W,Oka S,Zhai P,Sadoshima J,Del Re DP
Fri Aug 30 00:00:00 UTC 2019
let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7.
Cell reports
Buonfiglioli A,Efe IE,Guneykaya D,Ivanov A,Huang Y,Orlowski E,Krüger C,Deisz RA,Markovic D,Flüh C,Newman AG,Schneider UC,Beule D,Wolf SA,Dzaye O,Gutmann DH,Semtner M,Kettenmann H,Lehnardt S
315-02 was used in In vitro experiments to investigate whether let-7 miRNA family members differentially control microglia biology in health and disease.
Tue Dec 10 00:00:00 UTC 2019
Encapsulation of macrophages enhances their retention and angiogenic potential.
NPJ Regenerative medicine
Ludwinski FE,Patel AS,Damodaran G,Cho J,Furmston J,Xu Q,Jayasinghe SN,Smith A,Modarai B
Fri Sep 24 00:00:00 UTC 2021
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Cell reports
Bailey JD,Diotallevi M,Nicol T,McNeill E,Shaw A,Chuaiphichai S,Hale A,Starr A,Nandi M,Stylianou E,McShane H,Davis S,Fischer R,Kessler BM,McCullagh J,Channon KM,Crabtree MJ
315-02 was used in Cell Culture to investigate nitrogen oxide in mitochondrial respiration for macrophage activation.
Tue Jul 02 00:00:00 UTC 2019
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.
Cell death & disease
Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y
Fri Dec 20 00:00:00 UTC 2019
The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.
JCI insight
Yifa O,Weisinger K,Bassat E,Li H,Kain D,Barr H,Kozer N,Genzelinakh A,Rajchman D,Eigler T,Umansky KB,Lendengolts D,Brener O,Bursac N,Tzahor E
315-02 was used in Cell Culture to demonstrate that Chicago Sky Blue 6B (CSB) molecule is a potential therapeutic agent for cardiac repair in CHD given its ability to suppress detrimental postinjury processes.
Thu Nov 14 00:00:00 UTC 2019
eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice.
Cell death & disease
Li J,Li X,Liu D,Hamamura K,Wan Q,Na S,Yokota H,Zhang P
Wed Dec 04 00:00:00 UTC 2019
Macrophage-derived HMGB1 is dispensable for tissue fibrogenesis.
FASEB bioAdvances
Personnaz J,Piccolo E,Branchereau M,Filliol A,Paccoud R,Moreau E,Calise D,Riant E,Gourdy P,Heymes C,Schwabe RF,Dray C,Valet P,Pradère JP
Mon Apr 01 00:00:00 UTC 2019
Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages.
International journal of molecular sciences
Muschter D,Beiderbeck AS,Späth T,Kirschneck C,Schröder A,Grässel S
315-02 was used in Cell Culture to demonstrate that sensory neuropeptide SP and its receptor NK1R, as well as αCGRP and its receptor CRLR/Ramp1, are involved in the mechano-regulation of murine macrophages.
Thu Jan 24 00:00:00 UTC 2019
G-protein Gα13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Scientific reports
Nakano S,Inoue K,Xu C,Deng Z,Syrovatkina V,Vitone G,Zhao L,Huang XY,Zhao B
Tue Mar 12 00:00:00 UTC 2019
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Nature communications
Liao ST,Han C,Xu DQ,Fu XW,Wang JS,Kong LY
Fri Nov 08 00:00:00 UTC 2019
Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.
Theranostics
Rodell CB,Ahmed MS,Garris CS,Pittet MJ,Weissleder R
315-02 was used in Cell Culture to describe the development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy.
Mon Sep 14 00:00:00 UTC 2020
TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
Nature communications
Saito H,Gasser A,Bolamperti S,Maeda M,Matthies L,Jähn K,Long CL,Schlüter H,Kwiatkowski M,Saini V,Pajevic PD,Bellido T,van Wijnen AJ,Mohammad KS,Guise TA,Taipaleenmäki H,Hesse E
Fri Mar 22 00:00:00 UTC 2019
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.
Nature communications
Zhang F,Parayath NN,Ene CI,Stephan SB,Koehne AL,Coon ME,Holland EC,Stephan MT
Tue Sep 03 00:00:00 UTC 2019
Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair.
Nature communications
Yang W,Tao Y,Wu Y,Zhao X,Ye W,Zhao D,Fu L,Tian C,Yang J,He F,Tang L
Wed Mar 06 00:00:00 UTC 2019
mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis.
Scientific reports
Haloul M,Oliveira ERA,Kader M,Wells JZ,Tominello TR,El Andaloussi A,Yates CC,Ismail N
Tue Oct 01 00:00:00 UTC 2019
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Nature
Bambouskova M,Gorvel L,Lampropoulou V,Sergushichev A,Loginicheva E,Johnson K,Korenfeld D,Mathyer ME,Kim H,Huang LH,Duncan D,Bregman H,Keskin A,Santeford A,Apte RS,Sehgal R,Johnson B,Amarasinghe GK,Soares MP,Satoh T,Akira S,Hai T,de Guzman Strong C,Auclair K,Roddy TP,Biller SA,Jovanovic M,Klechevsky E,Stewart KM,Randolph GJ,Artyomov MN
Sun Apr 01 00:00:00 UTC 2018
Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response.
Cell
Xu X,Xu J,Wu J,Hu Y,Han Y,Gu Y,Zhao K,Zhang Q,Liu X,Liu J,Liu B,Cao X
Thu Nov 15 00:00:00 UTC 2018
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
Thu Feb 08 00:00:00 UTC 2018
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.
Cell
Cohen M,Giladi A,Gorki AD,Solodkin DG,Zada M,Hladik A,Miklosi A,Salame TM,Halpern KB,David E,Itzkovitz S,Harkany T,Knapp S,Amit I
Thu Nov 01 00:00:00 UTC 2018
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Nature methods
Squadrito ML,Cianciaruso C,Hansen SK,De Palma M
Thu Mar 01 00:00:00 UTC 2018
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Immunity
Guo C,Chi Z,Jiang D,Xu T,Yu W,Wang Z,Chen S,Zhang L,Liu Q,Guo X,Zhang X,Li W,Lu L,Wu Y,Song BL,Wang D
Tue Nov 20 00:00:00 UTC 2018
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Immunity
Ohto U,Ishida H,Shibata T,Sato R,Miyake K,Shimizu T
Tue Apr 17 00:00:00 UTC 2018
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
Immunity
Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler G,Huang SC,Pearce EL,Pearce EJ
Tue Dec 18 00:00:00 UTC 2018
Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.
Immunity
Trompette A,Gollwitzer ES,Pattaroni C,Lopez-Mejia IC,Riva E,Pernot J,Ubags N,Fajas L,Nicod LP,Marsland BJ
Tue May 15 00:00:00 UTC 2018
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Cancer cell
Medler TR,Murugan D,Horton W,Kumar S,Cotechini T,Forsyth AM,Leyshock P,Leitenberger JJ,Kulesz-Martin M,Margolin AA,Werb Z,Coussens LM
Mon Oct 08 00:00:00 UTC 2018
Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation.
Cell metabolism
Wang F,Zhang S,Vuckovic I,Jeon R,Lerman A,Folmes CD,Dzeja PP,Herrmann J
315-02 was used in Tissue/organ culture to confirm he inhibitory effect of 2-DG on glycolysis, but also demonstrate that 2-DG impairs oxidative phosphorylation and significantly reduces 13C-labeled Krebs cycle metabolites and intracellular ATP levels to indicate that glycolytic stimulation is not required for M2 macrophage differentiation as long as oxidative phosphorylation remains active.
Tue Sep 04 00:00:00 UTC 2018
The β2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Cell host & microbe
Gluschko A,Herb M,Wiegmann K,Krut O,Neiss WF,Utermöhlen O,Krönke M,Schramm M
315-02 was used in Cell Culture to investigate macrophage response to Listeria monocytogenes infection.
Wed Mar 14 00:00:00 UTC 2018
Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion.
Blood
Youssef LA,Rebbaa A,Pampou S,Weisberg SP,Stockwell BR,Hod EA,Spitalnik SL
Thu Jun 07 00:00:00 UTC 2018
Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.
Blood
Haxaire C,Hakobyan N,Pannellini T,Carballo C,McIlwain D,Mak TW,Rodeo S,Acharya S,Li D,Szymonifka J,Song X,Monette S,Srivastava A,Salmon JE,Blobel CP
Thu Sep 06 00:00:00 UTC 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
Fri Jun 01 00:00:00 UTC 2018
A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.
Neuron
Bennett FC,Bennett ML,Yaqoob F,Mulinyawe SB,Grant GA,Hayden Gephart M,Plowey ED,Barres BA
Wed Jun 27 00:00:00 UTC 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 UTC 2018
Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.
The Journal of experimental medicine
Shaw TN,Houston SA,Wemyss K,Bridgeman HM,Barbera TA,Zangerle-Murray T,Strangward P,Ridley AJL,Wang P,Tamoutounour S,Allen JE,Konkel JE,Grainger JR
Mon Jun 04 00:00:00 UTC 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
Mon Apr 02 00:00:00 UTC 2018
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.
The Journal of experimental medicine
Huynh JP,Lin CC,Kimmey JM,Jarjour NN,Schwarzkopf EA,Bradstreet TR,Shchukina I,Shpynov O,Weaver CT,Taneja R,Artyomov MN,Edelson BT,Stallings CL
Mon Jul 02 00:00:00 UTC 2018
Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.
Bone research
Bartelt A,Behler-Janbeck F,Beil FT,Koehne T,Müller B,Schmidt T,Heine M,Ochs L,Yilmaz T,Dietrich M,Tuckermann JP,Amling M,Herz J,Schinke T,Heeren J,Niemeier A
Thu Oct 01 00:00:00 UTC 2020
Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Paschalis EI,Lei F,Zhou C,Kapoulea V,Dana R,Chodosh J,Vavvas DG,Dohlman CH
315-02 was used in In vitro experiments to illustrate that procceding an occular injury, CSF1R inhibition-resistant peripheral monocytes permanently remodel to a microglia-lilke phenotype.
Tue Nov 27 00:00:00 UTC 2018
Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.
Experimental & molecular medicine
Baek JM,Cheon YH,Kwak SC,Jun HY,Yoon KH,Lee MS,Kim JY
Fri Apr 27 00:00:00 UTC 2018
Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Li W,Deng Y,Feng B,Mak KK
315-02 was used in Cell Culture to investigate energy-need regulation of bone homeostasis, with clinical relevance to diabetes.
Fri Jun 01 00:00:00 UTC 2018
Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Liu Z,Han T,Werner H,Rosen CJ,Schaffler MB,Yakar S
315-02 was used in Cell Culture to study whether disruptions in the growth hormone/insulin-like growth factor-1 axis (GH/IGF-1) are related to low bone mass states in chronic liver disease using a mouse model of liver-specific GH-receptor (GHR) gene deletion (Li-GHRKO).
Mon Jan 01 00:00:00 UTC 2018
Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.
Journal of leukocyte biology
Ganesan R,Henkels KM,Wrenshall LE,Kanaho Y,Di Paolo G,Frohman MA,Gomez-Cambronero J
315-02 was used in Cell Culture to investigate cholesterol uptake by macrophages in eventual foam cell formation in vascular plaques.
Tue May 01 00:00:00 UTC 2018
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Benitez R,Delgado-Maroto V,Caro M,Forte-Lago I,Duran-Prado M,O'Valle F,Lichtman AH,Gonzalez-Rey E,Delgado M
Fri Jun 01 00:00:00 UTC 2018
Plastin 3 influences bone homeostasis through regulation of osteoclast activity.
Human molecular genetics
Neugebauer J,Heilig J,Hosseinibarkooie S,Ross BC,Mendoza-Ferreira N,Nolte F,Peters M,Hölker I,Hupperich K,Tschanz T,Grysko V,Zaucke F,Niehoff A,Wirth B
315-02 was used in In vitro experiments to show that regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFκB-NFATC1 axis unveils a novel possibility to counteract osteoporosis.
Sat Dec 15 00:00:00 UTC 2018
Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly Differentiating into Osteocytes and Reducing Osteoclast Activity Reverses Osteoporosis in Ovariectomized Rats.
Cell transplantation
Fu YS,Lu CH,Chu KA,Yeh CC,Chiang TL,Ko TL,Chiu MM,Chen CF
315-02 was used in Cell Culture to study the effects of human umbilical cord-derived mesenchymal stem cells (HUMSCs) in Wharton's jelly on ovariectomy (OVX)-induced osteoporosis by using in vitro and in vivo experiments.
Mon Jan 01 00:00:00 UTC 2018
FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression.
BioMed research international
Lv ZT,Liang S,Chen K,Zhang JM,Cheng P,Guo JC,Yang Q,Zhou CH,Liao H,Chen AM
315-02 was used in In vitro experiments to investigate the role and mechanisms of FNDC4 in osteoclast differentiation.
Mon Jan 14 00:00:00 UTC 2019
Rab32-related antimicrobial pathway is involved in the progression of dextran sodium sulfate-induced colitis.
FEBS open bio
Xie X,Ni Q,Zhou D,Wan Y
Mon Oct 01 00:00:00 UTC 2018
The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress.
Cell death & disease
Tao L,Lin H,Wen J,Sun Q,Gao Y,Xu X,Wang J,Zhang J,Weng D
Tue May 29 00:00:00 UTC 2018
Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.
Cell death & disease
Weng Q,Wang J,Wang J,Wang J,Sattar F,Zhang Z,Zheng J,Xu Z,Zhao M,Liu X,Yang L,Hao G,Fang L,Lu QR,Yang B,He Q
Wed Feb 14 00:00:00 UTC 2018
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Nature communications
Wang S,Lin Y,Yuan X,Li F,Guo L,Wu B
Fri Oct 12 00:00:00 UTC 2018
Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.
The Journal of biological chemistry
Ko CW,Counihan D,Wu J,Hatzoglou M,Puchowicz MA,Croniger CM
Fri Mar 02 00:00:00 UTC 2018
In vitro Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells.
Bio-protocol
Zhuang X,Hu G
315-02 was used in Cell Culture to describe an osteoclastogenesis protocol which can be used to evaluate the effect of different factors such as cytokines, small molecular chemicals and conditioned medium from cell culture, on osteoclast differentiation using primary murine bone marrow cells.
Tue Jun 05 00:00:00 UTC 2018
IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner.
Cell death & disease
Zhao M,Li Y,Guo C,Wang L,Chu H,Zhu F,Li Y,Wang X,Wang Q,Zhao W,Shi Y,Chen W,Zhang L
Tue May 22 00:00:00 UTC 2018
DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
The Journal of biological chemistry
Lao Y,Yang K,Wang Z,Sun X,Zou Q,Yu X,Cheng J,Tong X,Yeh ETH,Yang J,Yi J
Fri Mar 16 00:00:00 UTC 2018
Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts.
Scientific reports
Niedermair T,Schirner S,Seebröker R,Straub RH,Grässel S
Fri Jun 15 00:00:00 UTC 2018
Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells.
Molecular & cellular proteomics : MCP
Di Lorenzo G,Velho RV,Winter D,Thelen M,Ahmadi S,Schweizer M,De Pace R,Cornils K,Yorgan TA,Grüb S,Hermans-Borgmeyer I,Schinke T,Müller-Loennies S,Braulke T,Pohl S
Wed Aug 01 00:00:00 UTC 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 UTC 2018
Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry.
The Journal of biological chemistry
Xiao Y,Li M,Larocque R,Zhang F,Malhotra A,Chen J,Linhardt RJ,Konermann L,Xu D
Fri Nov 09 00:00:00 UTC 2018
High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation.
The Journal of biological chemistry
Shridas P,De Beer MC,Webb NR
Fri Aug 24 00:00:00 UTC 2018
Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
Nature communications
Liu Z,Qin Q,Wu C,Li H,Shou J,Yang Y,Gu M,Ma C,Lin W,Zou Y,Zhang Y,Ma F,Sun J,Wang X
Tue Jul 17 00:00:00 UTC 2018
Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage.
Cell death & disease
Song F,Yi Y,Li C,Hu Y,Wang J,Smith DE,Jiang H
Tue Jul 10 00:00:00 UTC 2018
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.
Nature communications
Soderborg TK,Clark SE,Mulligan CE,Janssen RC,Babcock L,Ir D,Young B,Krebs N,Lemas DJ,Johnson LK,Weir T,Lenz LL,Frank DN,Hernandez TL,Kuhn KA,D'Alessandro A,Barbour LA,El Kasmi KC,Friedman JE
Fri Oct 26 00:00:00 UTC 2018
Imatinib reduces non-alcoholic fatty liver disease in obese mice by targeting inflammatory and lipogenic pathways in macrophages and liver.
Scientific reports
AlAsfoor S,Rohm TV,Bosch AJT,Dervos T,Calabrese D,Matter MS,Weber A,Cavelti-Weder C
Wed Oct 17 00:00:00 UTC 2018
Chimeric antigen receptors that trigger phagocytosis.
eLife
Morrissey MA,Williamson AP,Steinbach AM,Roberts EW,Kern N,Headley MB,Vale RD
315-02 was used in Cell Culture to develop a family of chimeric antigen receptors for phagocytosis, and study their use against cancer cells.
Mon Jun 04 00:00:00 UTC 2018
Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation.
Cell death & disease
Chung IC,Yuan SN,OuYang CN,Lin HC,Huang KY,Chen YJ,Chung AK,Chu CL,Ojcius DM,Chang YS,Chen LC
Wed Oct 31 00:00:00 UTC 2018
Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway.
Cell death & disease
Wu H,Hu B,Zhou X,Zhou C,Meng J,Yang Y,Zhao X,Shi Z,Yan S
Tue May 01 00:00:00 UTC 2018
Inhibition of inflammasome activation by a clinical strain of Klebsiella pneumoniae impairs efferocytosis and leads to bacterial dissemination.
Cell death & disease
Codo AC,Saraiva AC,Dos Santos LL,Visconde MF,Gales AC,Zamboni DS,Medeiros AI
Wed Dec 05 00:00:00 UTC 2018
Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis.
Oncotarget
Karpurapu M,Lee YG,Qian Z,Wen J,Ballinger MN,Rusu L,Chung S,Deng J,Qian F,Reader BF,Nirujogi TS,Park GY,Pei D,Christman JW
315-02 was used in Sample Preparation (Western Blotting) to demonstrate that inhibition of NFATc3 activation by CP9-ZIZIT provides a potential therapeutic option for attenuating sepsis induced ALI/pulmonary edema.
Tue Feb 13 00:00:00 UTC 2018
Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis.
Oncotarget
Karpurapu M,Lee YG,Qian Z,Wen J,Ballinger MN,Rusu L,Chung S,Deng J,Qian F,Reader BF,Nirujogi TS,Park GY,Pei D,Christman JW
315-02 was used in Sample Preparation (Western Blotting) to demonstrate that inhibition of NFATc3 activation by CP9-ZIZIT provides a potential therapeutic option for attenuating sepsis induced ALI/pulmonary edema.
Tue Feb 13 00:00:00 UTC 2018
Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer.
Nature communications
Nam GH,Lee EJ,Kim YK,Hong Y,Choi Y,Ryu MJ,Woo J,Cho Y,Ahn DJ,Yang Y,Kwon IC,Park SY,Kim IS
Mon Jun 04 00:00:00 UTC 2018
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
Fri Oct 12 00:00:00 UTC 2018
Bone protection by inhibition of microRNA-182.
Nature communications
Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B
Fri Oct 05 00:00:00 UTC 2018
Visual Osteoclast Fusion via A Fluorescence Method.
Scientific reports
Li B,Yu F,Wu F,Wang K,Lou F,Zhang D,Liao X,Yin B,Wang C,Ye L
Thu Jul 05 00:00:00 UTC 2018
Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Li Z,Jia Y,Han S,Wang X,Han F,Zhang J,Zhang W,Guan H,Hu D
315-02 was used in Cell Culture to investigate Klf4 in inflammation.
Fri Aug 17 00:00:00 UTC 2018
p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.
The Journal of biological chemistry
Zach F,Polzer F,Mueller A,Gessner A
Fri Jun 15 00:00:00 UTC 2018
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.
Nature communications
Lopes N,Charaix J,Cédile O,Sergé A,Irla M
Wed Mar 28 00:00:00 UTC 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 UTC 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 UTC 2018
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 UTC 2017
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
Cell
Topper MJ,Vaz M,Chiappinelli KB,DeStefano Shields CE,Niknafs N,Yen RC,Wenzel A,Hicks J,Ballew M,Stone M,Tran PT,Zahnow CA,Hellmann MD,Anagnostou V,Strissel PL,Strick R,Velculescu VE,Baylin SB
Thu Nov 30 00:00:00 UTC 2017
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
Thu Aug 24 00:00:00 UTC 2017
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.
Immunity
Xu MM,Pu Y,Han D,Shi Y,Cao X,Liang H,Chen X,Li XD,Deng L,Chen ZJ,Weichselbaum RR,Fu YX
Tue Aug 15 00:00:00 UTC 2017
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Immunity
Zhu Y,Herndon JM,Sojka DK,Kim KW,Knolhoff BL,Zuo C,Cullinan DR,Luo J,Bearden AR,Lavine KJ,Yokoyama WM,Hawkins WG,Fields RC,Randolph GJ,DeNardo DG
Tue Aug 15 00:00:00 UTC 2017
Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.
Immunity
Yáñez A,Coetzee SG,Olsson A,Muench DE,Berman BP,Hazelett DJ,Salomonis N,Grimes HL,Goodridge HS
Tue Nov 21 00:00:00 UTC 2017
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Cell host & microbe
Wlodarska M,Luo C,Kolde R,d'Hennezel E,Annand JW,Heim CE,Krastel P,Schmitt EK,Omar AS,Creasey EA,Garner AL,Mohammadi S,O'Connell DJ,Abubucker S,Arthur TD,Franzosa EA,Huttenhower C,Murphy LO,Haiser HJ,Vlamakis H,Porter JA,Xavier RJ
315-02 was used in Cell Culture to investigate the relationship between commensal intestinal microbes and the mucous layer.
Wed Jul 12 00:00:00 UTC 2017
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood
Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T
Thu Mar 23 00:00:00 UTC 2017
Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
The Journal of experimental medicine
Tsai F,Homan PJ,Agrawal H,Misharin AV,Abdala-Valencia H,Haines GK,Dominguez S,Bloomfield CL,Saber R,Chang A,Mohan C,Hutcheson J,Davidson A,Budinger GRS,Bouillet P,Dorfleutner A,Stehlik C,Winter DR,Cuda CM,Perlman H
Mon Dec 04 00:00:00 UTC 2017
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.
The Journal of experimental medicine
Liu W,Liu X,Li Y,Zhao J,Liu Z,Hu Z,Wang Y,Yao Y,Miller AW,Su B,Cookson MR,Li X,Kang Z
Mon Oct 02 00:00:00 UTC 2017
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.
The Journal of experimental medicine
Karmaus PWF,Herrada AA,Guy C,Neale G,Dhungana Y,Long L,Vogel P,Avila J,Clish CB,Chi H
Mon Sep 04 00:00:00 UTC 2017
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
The Journal of experimental medicine
Choo MK,Sano Y,Kim C,Yasuda K,Li XD,Lin X,Stenzel-Poore M,Alexopoulou L,Ghosh S,Latz E,Rifkin IR,Chen ZJ,Stewart GC,Chong H,Park JM
Mon May 01 00:00:00 UTC 2017
RANKL-induced M1 macrophages are involved in bone formation.
Bone research
Huang R,Wang X,Zhou Y,Xiao Y
315-02 was used in Cell Culture to investigate M1 macrophage stimulation with lipopolysaccharide and interferon-y stimulation.
Tue Jun 04 00:00:00 UTC 2024
Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Kanemaru H,Yamane F,Fukushima K,Matsuki T,Kawasaki T,Ebina I,Kuniyoshi K,Tanaka H,Maruyama K,Maeda K,Satoh T,Akira S
Tue Aug 29 00:00:00 UTC 2017
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Journal of immunology (Baltimore, Md. : 1950)
Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI
Mon May 15 00:00:00 UTC 2017
Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control.
Journal of immunology (Baltimore, Md. : 1950)
Jongstra-Bilen J,Zhang CX,Wisnicki T,Li MK,White-Alfred S,Ilaalagan R,Ferri DM,Deonarain A,Wan MH,Hyduk SJ,Cummins CL,Cybulsky MI
Fri Sep 15 00:00:00 UTC 2017
Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner.
Journal of immunology (Baltimore, Md. : 1950)
Coorens M,Schneider VAF,de Groot AM,van Dijk A,Meijerink M,Wells JM,Scheenstra MR,Veldhuizen EJA,Haagsman HP
Tue Aug 15 00:00:00 UTC 2017
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Deng W,Yang J,Lin X,Shin J,Gao J,Zhong XP
Sun Jan 01 00:00:00 UTC 2017
Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling.
Journal of cellular and molecular medicine
Lu L,Rao L,Jia H,Chen J,Lu X,Yang G,Li Q,Lee KKH,Yang L
Sat Jul 01 00:00:00 UTC 2017
The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
FEBS letters
Lee JY,Seo D,You J,Chung S,Park JS,Lee JH,Jung SM,Lee YS,Park SH
Wed Feb 01 00:00:00 UTC 2017
Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.
Developmental dynamics : an official publication of the American Association of Anatomists
Tarnawsky SP,Yoshimoto M,Deng L,Chan RJ,Yoder MC
315-02 was used in Cell Culture to investigate the effects of juvenile myelomonocytic leukemia-initiating PTPN11 mutations on pediatric myeloproliferative neoplasm.
Fri Dec 01 00:00:00 UTC 2017
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Scientific reports
Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K
Mon Oct 16 00:00:00 UTC 2017
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.
Nature communications
Saitoh SI,Abe F,Kanno A,Tanimura N,Mori Saitoh Y,Fukui R,Shibata T,Sato K,Ichinohe T,Hayashi M,Kubota K,Kozuka-Hata H,Oyama M,Kikko Y,Katada T,Kontani K,Miyake K
Fri Nov 17 00:00:00 UTC 2017
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.
Nature communications
Guo W,Liu W,Chen Z,Gu Y,Peng S,Shen L,Shen Y,Wang X,Feng GS,Sun Y,Xu Q
Mon Dec 18 00:00:00 UTC 2017
Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.
The Journal of biological chemistry
Guo X,Li T,Xu Y,Xu X,Zhu Z,Zhang Y,Xu J,Xu K,Cheng H,Zhang X,Ke Y
Fri Aug 25 00:00:00 UTC 2017
Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway.
Scientific reports
Kim WS,Kim H,Jeong EM,Kim HJ,Lee ZH,Kim IG,Kim HH
Wed Sep 06 00:00:00 UTC 2017
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.
Nature communications
Deczkowska A,Matcovitch-Natan O,Tsitsou-Kampeli A,Ben-Hamo S,Dvir-Szternfeld R,Spinrad A,Singer O,David E,Winter DR,Smith LK,Kertser A,Baruch K,Rosenzweig N,Terem A,Prinz M,Villeda S,Citri A,Amit I,Schwartz M
Thu Sep 28 00:00:00 UTC 2017
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.
Nature communications
Krishnasamy K,Limbourg A,Kapanadze T,Gamrekelashvili J,Beger C,Häger C,Lozanovski VJ,Falk CS,Napp LC,Bauersachs J,Mack M,Haller H,Weber C,Adams RH,Limbourg FP
Mon Oct 16 00:00:00 UTC 2017
Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.
Scientific reports
Azario I,Pievani A,Del Priore F,Antolini L,Santi L,Corsi A,Cardinale L,Sawamoto K,Kubaski F,Gentner B,Bernardo ME,Valsecchi MG,Riminucci M,Tomatsu S,Aiuti A,Biondi A,Serafini M
Fri Aug 25 00:00:00 UTC 2017
FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Scientific reports
Park MY,Kim HS,Lee M,Park B,Lee HY,Cho EB,Seong JY,Bae YS
Tue Nov 14 00:00:00 UTC 2017
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.
Nature communications
Gao Z,Li Y,Wang F,Huang T,Fan K,Zhang Y,Zhong J,Cao Q,Chao T,Jia J,Yang S,Zhang L,Xiao Y,Zhou JY,Feng XH,Jin J
Mon Nov 27 00:00:00 UTC 2017
Inhibition of intimal hyperplasia in murine aortic allografts by administration of a small-molecule TLR4 inhibitor TAK-242.
Scientific reports
Wu C,Ding X,Zhou C,Ye P,Sun Y,Wu J,Zhang A,Huang X,Ren L,Wang K,Deng P,Yue Z,Chen J,Wang S,Xia J
Fri Nov 17 00:00:00 UTC 2017
Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.
Nature communications
Davies LC,Rice CM,Palmieri EM,Taylor PR,Kuhns DB,McVicar DW
Tue Dec 12 00:00:00 UTC 2017
Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1.
Oncotarget
Zhu X,Zhao Y,Jiang Y,Qin T,Chen J,Chu X,Yi Q,Gao S,Wang S
315-02 was used in Cell Culture to study the underlying mechanisms of how the agonist of dectin-1 inhibirs osteoclastogenesis and determine that curdlan potently inhibited RANKL-induced osteoclast differentiation and the resultant bone resorption.
Tue Aug 08 00:00:00 UTC 2017
A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages.
Scientific reports
Boorsma CE,van der Veen TA,Putri KSS,de Almeida A,Draijer C,Mauad T,Fejer G,Brandsma CA,van den Berge M,Bossé Y,Sin D,Hao K,Reithmeier A,Andersson G,Olinga P,Timens W,Casini A,Melgert BN
Tue Oct 03 00:00:00 UTC 2017
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.
Oncoimmunology
Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE
315-02 was used in In vitro experiments to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17-neutrophil axis.
Sat Jan 29 00:00:00 UTC 2022
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nature communications
Vincent J,Adura C,Gao P,Luz A,Lama L,Asano Y,Okamoto R,Imaeda T,Aida J,Rothamel K,Gogakos T,Steinberg J,Reasoner S,Aso K,Tuschl T,Patel DJ,Glickman JF,Ascano M
Fri Sep 29 00:00:00 UTC 2017
NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
Nature communications
Xiahou Z,Wang X,Shen J,Zhu X,Xu F,Hu R,Guo D,Li H,Tian Y,Liu Y,Liang H
Mon Oct 16 00:00:00 UTC 2017
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Cell
Freeman SA,Goyette J,Furuya W,Woods EC,Bertozzi CR,Bergmeier W,Hinz B,van der Merwe PA,Das R,Grinstein S
Thu Jan 14 00:00:00 UTC 2016
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
Thu Nov 17 00:00:00 UTC 2016
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.
Cell research
Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y
Tue Nov 01 00:00:00 UTC 2016
Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.
Immunity
Matthews SP,McMillan SJ,Colbert JD,Lawrence RA,Watts C
Tue Apr 19 00:00:00 UTC 2016
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.
Immunity
Menezes S,Melandri D,Anselmi G,Perchet T,Loschko J,Dubrot J,Patel R,Gautier EL,Hugues S,Longhi MP,Henry JY,Quezada SA,Lauvau G,Lennon-Duménil AM,Gutiérrez-Martínez E,Bessis A,Gomez-Perdiguero E,Jacome-Galarza CE,Garner H,Geissmann F,Golub R,Nussenzweig MC,Guermonprez P
Tue Dec 20 00:00:00 UTC 2016
EGFR regulates macrophage activation and function in bacterial infection.
The Journal of clinical investigation
Hardbower DM,Singh K,Asim M,Verriere TG,Olivares-Villagómez D,Barry DP,Allaman MM,Washington MK,Peek RM,Piazuelo MB,Wilson KT
Thu Sep 01 00:00:00 UTC 2016
TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Weaver LK,Chu N,Behrens EM
Tue Sep 27 00:00:00 UTC 2016
Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent.
Proceedings of the National Academy of Sciences of the United States of America
Liu L,Lu Y,Martinez J,Bi Y,Lian G,Wang T,Milasta S,Wang J,Yang M,Liu G,Green DR,Wang R
Tue Feb 09 00:00:00 UTC 2016
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proceedings of the National Academy of Sciences of the United States of America
Ramasamy S,Saez B,Mukhopadhyay S,Ding D,Ahmed AM,Chen X,Pucci F,Yamin R,Wang J,Pittet MJ,Kelleher CM,Scadden DT,Sweetser DA
Tue Feb 16 00:00:00 UTC 2016
PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Proceedings of the National Academy of Sciences of the United States of America
Hangai S,Ao T,Kimura Y,Matsuki K,Kawamura T,Negishi H,Nishio J,Kodama T,Taniguchi T,Yanai H
Tue Apr 05 00:00:00 UTC 2016
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Proceedings of the National Academy of Sciences of the United States of America
Sockolosky JT,Dougan M,Ingram JR,Ho CC,Kauke MJ,Almo SC,Ploegh HL,Garcia KC
Tue May 10 00:00:00 UTC 2016
miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα.
Molecular therapy. Nucleic acids
Bi J,Zeng X,Zhao L,Wei Q,Yu L,Wang X,Yu Z,Cao Y,Shan F,Wei M
Tue Sep 27 00:00:00 UTC 2016
Deletion of FGFR3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Su N,Li X,Tang Y,Yang J,Wen X,Guo J,Tang J,Du X,Chen L
Thu Sep 01 00:00:00 UTC 2016
Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo.
Journal of cell communication and signaling
Alsulaiman M,Bais MV,Trackman PC
315-02 was used in Cell Culture to study the effect of LOX-PP on bone marroe cell proliferation and differentiation towards osteoblast or osteoclasts, and LOX-PP modulation of prostate cancer cell conditioned media-induced alterations of proliferation and differentiation of bone marrow cells in vitro.
Tue Mar 01 00:00:00 UTC 2016
The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin.
Journal of immunology (Baltimore, Md. : 1950)
Corna G,Caserta I,Monno A,Apostoli P,Manfredi AA,Camaschella C,Rovere-Querini P
Thu Sep 01 00:00:00 UTC 2016
Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.
Journal of immunology (Baltimore, Md. : 1950)
Kolter J,Feuerstein R,Spoeri E,Gharun K,Elling R,Trieu-Cuot P,Goldmann T,Waskow C,Chen ZJ,Kirschning CJ,Deshmukh SD,Henneke P
Tue Mar 15 00:00:00 UTC 2016
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Peschke K,Achleitner M,Frenzel K,Gerbaulet A,Ada SR,Zeller N,Lienenklaus S,Lesche M,Poulet C,Naumann R,Dahl A,Ravens U,Günther C,Müller W,Knobeloch KP,Prinz M,Roers A,Behrendt R
Thu Sep 15 00:00:00 UTC 2016
Inclusion of Epitopes That Expand High-Avidity CD4+ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis.
Journal of immunology (Baltimore, Md. : 1950)
Roberts LM,Crane DD,Wehrly TD,Fletcher JR,Jones BD,Bosio CM
Sat Oct 01 00:00:00 UTC 2016
Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.
Journal of immunology (Baltimore, Md. : 1950)
Yim HY,Park C,Lee YD,Arimoto K,Jeon R,Baek SH,Zhang DE,Kim HH,Kim KI
Sun May 01 00:00:00 UTC 2016
The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis.
Journal of immunology (Baltimore, Md. : 1950)
Izawa T,Arakaki R,Mori H,Tsunematsu T,Kudo Y,Tanaka E,Ishimaru N
Thu Dec 15 00:00:00 UTC 2016
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Patin EC,Jones AV,Thompson A,Clement M,Liao CT,Griffiths JS,Wallace LE,Bryant CE,Lang R,Rosenstiel P,Humphreys IR,Taylor PR,Jones GW,Orr SJ
Fri Jul 01 00:00:00 UTC 2016
Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Alberts-Grill N,Engelbertsen D,Bu D,Foks A,Grabie N,Herter JM,Kuperwaser F,Chen T,Destefano G,Jarolim P,Lichtman AH
Thu Dec 15 00:00:00 UTC 2016
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Shimojima C,Takeuchi H,Jin S,Parajuli B,Hattori H,Suzumura A,Hibi H,Ueda M,Yamamoto A
Sun May 15 00:00:00 UTC 2016
Microbial metabolite butyrate facilitates M2 macrophage polarization and function.
Scientific reports
Ji J,Shu D,Zheng M,Wang J,Luo C,Wang Y,Guo F,Zou X,Lv X,Li Y,Liu T,Qu H
Wed Apr 20 00:00:00 UTC 2016
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nature communications
Iwata H,Goettsch C,Sharma A,Ricchiuto P,Goh WW,Halu A,Yamada I,Yoshida H,Hara T,Wei M,Inoue N,Fukuda D,Mojcher A,Mattson PC,Barabási AL,Boothby M,Aikawa E,Singh SA,Aikawa M
Mon Oct 31 00:00:00 UTC 2016
RNA editing generates cellular subsets with diverse sequence within populations.
Nature communications
Harjanto D,Papamarkou T,Oates CJ,Rayon-Estrada V,Papavasiliou FN,Papavasiliou A
Fri Jul 15 00:00:00 UTC 2016
Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.
Scientific reports
Shi C,Iura A,Terajima M,Liu F,Lyons K,Pan H,Zhang H,Yamauchi M,Mishina Y,Sun H
Wed Apr 06 00:00:00 UTC 2016
Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity.
Scientific reports
Lin KH,Chang LS,Tian CY,Yeh YC,Chen YJ,Chuang TH,Liu SJ,Leng CH
Mon Apr 11 00:00:00 UTC 2016
High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.
Oncotarget
Chen GL,Luo Y,Eriksson D,Meng X,Qian C,Bäuerle T,Chen XX,Schett G,Bozec A
315-02 was used in Cell Culture to examine the mechanisms by which a high-fat diet promotes melanoma growth in the bone marrow.
Tue May 03 00:00:00 UTC 2016
Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.
Scientific reports
Wong C,Bezhaeva T,Rothuizen TC,Metselaar JM,de Vries MR,Verbeek FP,Vahrmeijer AL,Wezel A,van Zonneveld AJ,Rabelink TJ,Quax PH,Rotmans JI
Wed Jul 27 00:00:00 UTC 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Tue Aug 09 00:00:00 UTC 2016
A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis.
Scientific reports
Kim Y,Yi H,Jung H,Rim YA,Park N,Kim J,Jung SM,Park SH,Park YW,Ju JH
Thu Feb 04 00:00:00 UTC 2016
Heparan Sulfate Regulates the Structure and Function of Osteoprotegerin in Osteoclastogenesis.
The Journal of biological chemistry
Li M,Yang S,Xu D
Fri Nov 11 00:00:00 UTC 2016
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nature communications
Gamrekelashvili J,Giagnorio R,Jussofie J,Soehnlein O,Duchene J,Briseño CG,Ramasamy SK,Krishnasamy K,Limbourg A,Kapanadze T,Ishifune C,Hinkel R,Radtke F,Strobl LJ,Zimber-Strobl U,Napp LC,Bauersachs J,Haller H,Yasutomo K,Kupatt C,Murphy KM,Adams RH,Weber C,Limbourg FP
Wed Aug 31 00:00:00 UTC 2016
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
The Journal of biological chemistry
Yao Y,Shi Q,Chen B,Wang Q,Li X,Li L,Huang Y,Ji J,Shen P
Fri Aug 12 00:00:00 UTC 2016
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages.
PloS one
Smalley C,Bechelli J,Rockx-Brouwer D,Saito T,Azar SR,Ismail N,Walker DH,Fang R
315-02 was used in Cell Culture to illustrate the activation of ASC-dependent inflammasome by R. australis in macrophages in which NLRP3 is involved.
Mon Jul 24 00:00:00 UTC 2017
M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation.
Scientific reports
Okubo M,Kioi M,Nakashima H,Sugiura K,Mitsudo K,Aoki I,Taniguchi H,Tohnai I
Wed Jun 08 00:00:00 UTC 2016
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
Cell death & disease
Kang H,Yan Y,Jia P,Yang K,Guo C,Chen H,Qi J,Qian N,Xu X,Wang F,Li C,Guo L,Deng L
Thu Oct 27 00:00:00 UTC 2016
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.
Scientific reports
McGuire VA,Ruiz-Zorrilla Diez T,Emmerich CH,Strickson S,Ritorto MS,Sutavani RV,Weiβ A,Houslay KF,Knebel A,Meakin PJ,Phair IR,Ashford ML,Trost M,Arthur JS
Mon Aug 08 00:00:00 UTC 2016
Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
The Journal of biological chemistry
Shrestha E,Hussein MA,Savas JN,Ouimet M,Barrett TJ,Leone S,Yates JR,Moore KJ,Fisher EA,Garabedian MJ
Fri May 20 00:00:00 UTC 2016
Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus.
Scientific reports
Uematsu T,Fujita T,Nakaoka HJ,Hara T,Kobayashi N,Murakami Y,Seiki M,Sakamoto T
Thu Nov 24 00:00:00 UTC 2016
Ablation of Y1 receptor impairs osteoclast bone-resorbing activity.
Scientific reports
Sousa DM,Conceição F,Silva DI,Leitão L,Neto E,Alves CJ,Alencastre IS,Herzog H,Aguiar P,Lamghari M
Tue Sep 20 00:00:00 UTC 2016
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
The Journal of biological chemistry
Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y
Fri Aug 26 00:00:00 UTC 2016
Inhibition of Osteoclast Differentiation and Bone Resorption by Bisphosphonate-conjugated Gold Nanoparticles.
Scientific reports
Lee D,Heo DN,Kim HJ,Ko WK,Lee SJ,Heo M,Bang JB,Lee JB,Hwang DS,Do SH,Kwon IK
Thu Jun 02 00:00:00 UTC 2016
Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages.
Scientific reports
Toyonaga T,Matsuura M,Mori K,Honzawa Y,Minami N,Yamada S,Kobayashi T,Hibi T,Nakase H
Thu Oct 13 00:00:00 UTC 2016
Th2 and eosinophil responses suppress inflammatory arthritis.
Nature communications
Chen Z,Andreev D,Oeser K,Krljanac B,Hueber A,Kleyer A,Voehringer D,Schett G,Bozec A
Tue Jun 07 00:00:00 UTC 2016
Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass.
Scientific reports
Hirozane T,Tohmonda T,Yoda M,Shimoda M,Kanai Y,Matsumoto M,Morioka H,Nakamura M,Horiuchi K
Wed Sep 28 00:00:00 UTC 2016
NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1.
Scientific reports
Kang IS,Kim C
Tue Nov 29 00:00:00 UTC 2016
Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus.
Cell death & disease
Li X,Liu F,Zhang X,Shi G,Ren J,Ji J,Ding L,Fan H,Dou H,Hou Y
Thu Aug 18 00:00:00 UTC 2016
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.
Scientific reports
Huber R,Meier B,Otsuka A,Fenini G,Satoh T,Gehrke S,Widmer D,Levesque MP,Mangana J,Kerl K,Gebhardt C,Fujii H,Nakashima C,Nonomura Y,Kabashima K,Dummer R,Contassot E,French LE
Mon Jul 18 00:00:00 UTC 2016
Production of Osteoclasts for Studying Protein Tyrosine Phosphatase Signaling.
Methods in molecular biology (Clifton, N.J.)
Finkelshtein E,Levy-Apter E,Elson A
315-02 was used in In vitro experiments to describe preparation and growth of osteoclasts from bone marrow of mice, use of viral vectors to downregulate expression of endogenous proteins and to express exogenous proteins in osteoclasts, and analysis of signaling processes triggered by M-CSF, estrogen, and physical contact with matrix in these cells.
Tue Jan 02 00:00:00 UTC 2018
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.
Nature communications
Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,Guo DA,Zhu H,Tan W,Lu A,Zhang G
Mon Mar 07 00:00:00 UTC 2016
Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.
Nature communications
de Bruin RG,Shiue L,Prins J,de Boer HC,Singh A,Fagg WS,van Gils JM,Duijs JM,Katzman S,Kraaijeveld AO,Böhringer S,Leung WY,Kielbasa SM,Donahue JP,van der Zande PH,Sijbom R,van Alem CM,Bot I,van Kooten C,Jukema JW,Van Esch H,Rabelink TJ,Kazan H,Biessen EA,Ares M,van Zonneveld AJ,van der Veer EP
Thu Mar 31 00:00:00 UTC 2016
Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.
Scientific reports
Kim HS,Tavakoli S,Piefer LA,Nguyen HN,Asmis R
Tue Sep 27 00:00:00 UTC 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
Wed Apr 06 00:00:00 UTC 2016
MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells.
Nature communications
Yu J,Lei R,Zhuang X,Li X,Li G,Lev S,Segura MF,Zhang X,Hu G
Tue Dec 20 00:00:00 UTC 2016
Bone-protective Functions of Netrin 1 Protein.
The Journal of biological chemistry
Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S
Fri Nov 11 00:00:00 UTC 2016
Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.
Immunity
Kearley J,Silver JS,Sanden C,Liu Z,Berlin AA,White N,Mori M,Pham TH,Ward CK,Criner GJ,Marchetti N,Mustelin T,Erjefalt JS,Kolbeck R,Humbles AA
Tue Mar 17 00:00:00 UTC 2015
T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
Blood
Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y
Thu Jan 08 00:00:00 UTC 2015
Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
The Journal of clinical investigation
Ersek A,Xu K,Antonopoulos A,Butters TD,Santo AE,Vattakuzhi Y,Williams LM,Goudevenou K,Danks L,Freidin A,Spanoudakis E,Parry S,Papaioannou M,Hatjiharissi E,Chaidos A,Alonzi DS,Twigg G,Hu M,Dwek RA,Haslam SM,Roberts I,Dell A,Rahemtulla A,Horwood NJ,Karadimitris A
Mon Jun 01 00:00:00 UTC 2015
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
The Journal of clinical investigation
Menéndez-Gutiérrez MP,Rőszer T,Fuentes L,Núñez V,Escolano A,Redondo JM,De Clerck N,Metzger D,Valledor AF,Ricote M
Sun Feb 01 00:00:00 UTC 2015
Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.
Proceedings of the National Academy of Sciences of the United States of America
Fiebiger BM,Maamary J,Pincetic A,Ravetch JV
Tue May 05 00:00:00 UTC 2015
Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages.
Proceedings of the National Academy of Sciences of the United States of America
van der Heijden J,Bosman ES,Reynolds LA,Finlay BB
Tue Jan 13 00:00:00 UTC 2015
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Experimental & molecular medicine
Oh E,Lee HY,Kim HJ,Park YJ,Seo JK,Park JS,Bae YS
Fri Nov 13 00:00:00 UTC 2015
Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.
The Journal of cell biology
Carroll-Portillo A,Cannon JL,te Riet J,Holmes A,Kawakami Y,Kawakami T,Cambi A,Lidke DS
Mon Aug 31 00:00:00 UTC 2015
ABCA1 contributes to macrophage deposition of extracellular cholesterol.
Journal of lipid research
Jin X,Freeman SR,Vaisman B,Liu Y,Chang J,Varsano N,Addadi L,Remaley A,Kruth HS
Tue Sep 01 00:00:00 UTC 2015
Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jeschke A,Catala-Lehnen P,Sieber S,Bickert T,Schweizer M,Koehne T,Wintges K,Marshall RP,Mautner A,Duchstein L,Otto B,Horst AK,Amling M,Kreienkamp HJ,Schinke T
Thu Oct 15 00:00:00 UTC 2015
DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.
Journal of immunology (Baltimore, Md. : 1950)
Spahn JH,Li W,Bribriesco AC,Liu J,Shen H,Ibricevic A,Pan JH,Zinselmeyer BH,Brody SL,Goldstein DR,Krupnick AS,Gelman AE,Miller MJ,Kreisel D
Wed Apr 15 00:00:00 UTC 2015
Novel Role of TRPML2 in the Regulation of the Innate Immune Response.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Hua Y,Vergarajauregui S,Diab HI,Puertollano R
Sun Nov 15 00:00:00 UTC 2015
Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
Journal of immunology (Baltimore, Md. : 1950)
Nadeau-Vallée M,Quiniou C,Palacios J,Hou X,Erfani A,Madaan A,Sanchez M,Leimert K,Boudreault A,Duhamel F,Rivera JC,Zhu T,Noueihed B,Robertson SA,Ni X,Olson DM,Lubell W,Girard S,Chemtob S
Thu Oct 01 00:00:00 UTC 2015
Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ding X,Yan Y,Li X,Li K,Ciric B,Yang J,Zhang Y,Wu S,Xu H,Chen W,Lovett-Racke AE,Zhang GX,Rostami A
Fri May 01 00:00:00 UTC 2015
Engulfment of activated apoptotic cells abolishes TGF-β-mediated immunoregulation via the induction of IL-6.
Journal of immunology (Baltimore, Md. : 1950)
Notley CA,Brown MA,McGovern JL,Jordan CK,Ehrenstein MR
Sun Feb 15 00:00:00 UTC 2015
Kupffer Cells Support Hepatitis B Virus-Mediated CD8+ T Cell Exhaustion via Hepatitis B Core Antigen-TLR2 Interactions in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Li M,Sun R,Xu L,Yin W,Chen Y,Zheng X,Lian Z,Wei H,Tian Z
Thu Oct 01 00:00:00 UTC 2015
Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Liu M,Luo F,Ding C,Albeituni S,Hu X,Ma Y,Cai Y,McNally L,Sanders MA,Jain D,Kloecker G,Bousamra M,Zhang HG,Higashi RM,Lane AN,Fan TW,Yan J
Sun Nov 15 00:00:00 UTC 2015
FOXO1 mediates RANKL-induced osteoclast formation and activity.
Journal of immunology (Baltimore, Md. : 1950)
Wang Y,Dong G,Jeon HH,Elazizi M,La LB,Hameedaldeen A,Xiao E,Tian C,Alsadun S,Choi Y,Graves DT
Sun Mar 15 00:00:00 UTC 2015
Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950)
Smallie T,Ross EA,Ammit AJ,Cunliffe HE,Tang T,Rosner DR,Ridley ML,Buckley CD,Saklatvala J,Dean JL,Clark AR
Wed Jul 01 00:00:00 UTC 2015
K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.
Journal of immunology (Baltimore, Md. : 1950)
Katsnelson MA,Rucker LG,Russo HM,Dubyak GR
Wed Apr 15 00:00:00 UTC 2015
Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.
Journal of immunology (Baltimore, Md. : 1950)
Ross EA,Smallie T,Ding Q,O'Neil JD,Cunliffe HE,Tang T,Rosner DR,Klevernic I,Morrice NA,Monaco C,Cunningham AF,Buckley CD,Saklatvala J,Dean JL,Clark AR
Wed Jul 01 00:00:00 UTC 2015
PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
Journal of immunology (Baltimore, Md. : 1950)
Drobek A,Kralova J,Skopcova T,Kucova M,Novák P,Angelisová P,Otahal P,Alberich-Jorda M,Brdicka T
Thu Oct 01 00:00:00 UTC 2015
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.
Journal of immunology (Baltimore, Md. : 1950)
Sakala IG,Kjer-Nielsen L,Eickhoff CS,Wang X,Blazevic A,Liu L,Fairlie DP,Rossjohn J,McCluskey J,Fremont DH,Hansen TH,Hoft DF
Wed Jul 15 00:00:00 UTC 2015
TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Hu MM,Xie XQ,Yang Q,Liao CY,Ye W,Lin H,Shu HB
Sun Nov 01 00:00:00 UTC 2015
Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.
Journal of immunology (Baltimore, Md. : 1950)
Davis MJ,Eastman AJ,Qiu Y,Gregorka B,Kozel TR,Osterholzer JJ,Curtis JL,Swanson JA,Olszewski MA
Sun Mar 01 00:00:00 UTC 2015
A Novel Function for P2Y2 in Myeloid Recipient-Derived Cells during Graft-versus-Host Disease.
Journal of immunology (Baltimore, Md. : 1950)
Klämbt V,Wohlfeil SA,Schwab L,Hülsdünker J,Ayata K,Apostolova P,Schmitt-Graeff A,Dierbach H,Prinz G,Follo M,Prinz M,Idzko M,Zeiser R
Tue Dec 15 00:00:00 UTC 2015
Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.
BioMed research international
Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C
315-02 was used in Sample Preparation (FC/FACS) to assess the effects of AGEs on macrophage polarization.
Fri Mar 18 00:00:00 UTC 2016
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.
Nature communications
Wan CK,Li P,Spolski R,Oh J,Andraski AB,Du N,Yu ZX,Dillon CP,Green DR,Leonard WJ
Thu Aug 13 00:00:00 UTC 2015
Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.
Scientific reports
Guo T,Zhang L,Konermann A,Zhou H,Jin F,Liu W
Mon Jan 26 00:00:00 UTC 2015
Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.
The Journal of biological chemistry
Zhang Y,Nguyen T,Tang P,Kennedy NJ,Jiao H,Zhang M,Reynolds JM,Jaeschke A,Martin-Orozco N,Chung Y,He WM,Wang C,Jia W,Ge B,Davis RJ,Flavell RA,Dong C
Fri Jun 12 00:00:00 UTC 2015
Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Scientific reports
Uematsu T,Iizasa E,Kobayashi N,Yoshida H,Hara H
Wed Dec 02 00:00:00 UTC 2015
Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.
The Journal of biological chemistry
Hu N,Qiu Y,Dong F
Fri Oct 02 00:00:00 UTC 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 UTC 2015
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Nature communications
Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E
Mon Oct 05 00:00:00 UTC 2015
STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3.
Scientific reports
Kim HS,Kim DC,Kim HM,Kwon HJ,Kwon SJ,Kang SJ,Kim SC,Choi GE
Mon Aug 24 00:00:00 UTC 2015
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin.
Cell death & disease
Tan HY,Wang N,Man K,Tsao SW,Che CM,Feng Y
Thu Oct 22 00:00:00 UTC 2015
Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice.
Cell death & disease
Chen TH,Swarnkar G,Mbalaviele G,Abu-Amer Y
Thu Apr 16 00:00:00 UTC 2015
Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles.
Scientific reports
Tran TH,Rastogi R,Shelke J,Amiji MM
Wed Nov 18 00:00:00 UTC 2015
Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.
Cell death & disease
Sanders MG,Parsons MJ,Howard AG,Liu J,Fassio SR,Martinez JA,Bouchier-Hayes L
Thu Jul 09 00:00:00 UTC 2015
5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
The Journal of biological chemistry
Maruyama K,Fukasaka M,Uematsu S,Takeuchi O,Kondo T,Saitoh T,Martino MM,Akira S
Fri Apr 10 00:00:00 UTC 2015
A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles.
Scientific reports
Yu P,Li J,Jiang J,Zhao Z,Hui Z,Zhang J,Zheng Y,Ling D,Wang L,Jiang LH,Luo J,Zhu X,Yang W
Fri Dec 11 00:00:00 UTC 2015
TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation.
Nature communications
Ferri F,Parcelier A,Petit V,Gallouet AS,Lewandowski D,Dalloz M,van den Heuvel A,Kolovos P,Soler E,Squadrito ML,De Palma M,Davidson I,Rousselet G,Romeo PH
Mon Nov 23 00:00:00 UTC 2015
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Nature
Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M
Thu Feb 27 00:00:00 UTC 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Thu Mar 13 00:00:00 UTC 2014
Dissecting engineered cell types and enhancing cell fate conversion via CellNet.
Cell
Morris SA,Cahan P,Li H,Zhao AM,San Roman AK,Shivdasani RA,Collins JJ,Daley GQ
Thu Aug 14 00:00:00 UTC 2014
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Immunity
Zigmond E,Bernshtein B,Friedlander G,Walker CR,Yona S,Kim KW,Brenner O,Krauthgamer R,Varol C,Müller W,Jung S
Thu May 15 00:00:00 UTC 2014
DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis.
The Journal of clinical investigation
Wang Y,Lei R,Zhuang X,Zhang N,Pan H,Li G,Hu J,Pan X,Tao Q,Fu D,Xiao J,Chin YE,Kang Y,Yang Q,Hu G
Tue Apr 01 00:00:00 UTC 2014
RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.
The Journal of clinical investigation
Li S,Miller CH,Giannopoulou E,Hu X,Ivashkiv LB,Zhao B
Sat Nov 01 00:00:00 UTC 2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
The Journal of experimental medicine
Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L
Mon Dec 15 00:00:00 UTC 2014
The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.
Arthritis & rheumatology (Hoboken, N.J.)
Győri D,Csete D,Benkő S,Kulkarni S,Mandl P,Dobó-Nagy C,Vanhaesebroeck B,Stephens L,Hawkins PT,Mócsai A
Fri Aug 01 00:00:00 UTC 2014
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression.
Autophagy
Giegerich AK,Kuchler L,Sha LK,Knape T,Heide H,Wittig I,Behrends C,Brüne B,von Knethen A
315-02 was used in Cell Culture to show that PELI3/Pellino3, which is an E3 ubiquitin ligase and scaffold protein in TLR4-signaling, is impacted by autophagy in macrophages after LPS stimulation.
Mon Sep 14 00:00:00 UTC 2015
FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Clatworthy MR,Harford SK,Mathews RJ,Smith KG
Tue Dec 16 00:00:00 UTC 2014
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Proceedings of the National Academy of Sciences of the United States of America
Kuniyoshi K,Takeuchi O,Pandey S,Satoh T,Iwasaki H,Akira S,Kawai T
Tue Apr 15 00:00:00 UTC 2014
Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.
Proceedings of the National Academy of Sciences of the United States of America
Kobiyama K,Aoshi T,Narita H,Kuroda E,Hayashi M,Tetsutani K,Koyama S,Mochizuki S,Sakurai K,Katakai Y,Yasutomi Y,Saijo S,Iwakura Y,Akira S,Coban C,Ishii KJ
Tue Feb 25 00:00:00 UTC 2014
Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.
Proceedings of the National Academy of Sciences of the United States of America
Wang D,Fu L,Ning W,Guo L,Sun X,Dey SK,Chaturvedi R,Wilson KT,DuBois RN
Tue May 13 00:00:00 UTC 2014
ABCG1-mediated generation of extracellular cholesterol microdomains.
Journal of lipid research
Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS
Wed Jan 01 00:00:00 UTC 2014
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
He Q,Yang X,Gong Y,Kovalenko D,Canalis E,Rosen CJ,Friesel RE
Tue Dec 09 00:00:00 UTC 2014
CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,Xiao Z,Qu C,Cui W,Wang X,Du J
Sat Nov 15 00:00:00 UTC 2014
Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.
Journal of immunology (Baltimore, Md. : 1950)
Suárez-Fueyo A,Rojas JM,Cariaga AE,García E,Steiner BH,Barber DF,Puri KD,Carrera AC
Tue Jul 15 00:00:00 UTC 2014
Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Jing X,Zulfiqar F,Park SY,Núñez G,Dziarski R,Gupta D
Mon Sep 15 00:00:00 UTC 2014
Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing.
Journal of immunology (Baltimore, Md. : 1950)
Murakami Y,Fukui R,Motoi Y,Kanno A,Shibata T,Tanimura N,Saitoh S,Miyake K
Sat Nov 15 00:00:00 UTC 2014
Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury.
Journal of immunology (Baltimore, Md. : 1950)
Zigmond E,Samia-Grinberg S,Pasmanik-Chor M,Brazowski E,Shibolet O,Halpern Z,Varol C
Tue Jul 01 00:00:00 UTC 2014
JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T Cells and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Park JS,Lee J,Lim MA,Kim EK,Kim SM,Ryu JG,Lee JH,Kwok SK,Park KS,Kim HY,Park SH,Cho ML
Thu May 01 00:00:00 UTC 2014
Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
Journal of immunology (Baltimore, Md. : 1950)
Ma J,Becker C,Reyes C,Underhill DM
Sat Feb 15 00:00:00 UTC 2014
NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi T,Steinbach EC,Russo SM,Matsuoka K,Nochi T,Maharshak N,Borst LB,Hostager B,Garcia-Martinez JV,Rothman PB,Kashiwada M,Sheikh SZ,Murray PJ,Plevy SE
Sat Feb 15 00:00:00 UTC 2014
Histone deacetylase inhibitors modulate interleukin 6-dependent CD4+ T cell polarization in vitro and in vivo.
The Journal of biological chemistry
Glauben R,Sonnenberg E,Wetzel M,Mascagni P,Siegmund B
Fri Feb 28 00:00:00 UTC 2014
MiR-9 promotes microglial activation by targeting MCPIP1.
Nature communications
Yao H,Ma R,Yang L,Hu G,Chen X,Duan M,Kook Y,Niu F,Liao K,Fu M,Hu G,Kolattukudy P,Buch S
Mon Jul 14 00:00:00 UTC 2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Nature communications
Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M
Tue Nov 24 00:00:00 UTC 2015
Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.
The Journal of biological chemistry
He L,Marneros AG
Fri Mar 21 00:00:00 UTC 2014
Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.
The Journal of biological chemistry
Ahn BJ,Le H,Shin MW,Bae SJ,Lee EJ,Wee HJ,Cha JH,Lee HJ,Lee HS,Kim JH,Kim CY,Seo JH,Lo EH,Jeon S,Lee MN,Oh GT,Yin GN,Ryu JK,Suh JK,Kim KW
Fri Feb 07 00:00:00 UTC 2014
Post-translational regulation of mitogen-activated protein kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their stability.
The Journal of biological chemistry
Crowell S,Wancket LM,Shakibi Y,Xu P,Xue J,Samavati L,Nelin LD,Liu Y
Fri Oct 17 00:00:00 UTC 2014
High bone mass in mice lacking Cx37 because of defective osteoclast differentiation.
The Journal of biological chemistry
Pacheco-Costa R,Hassan I,Reginato RD,Davis HM,Bruzzaniti A,Allen MR,Plotkin LI
Fri Mar 21 00:00:00 UTC 2014
Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
The Journal of biological chemistry
Kuriakose T,Rada B,Watford WT
Fri Dec 26 00:00:00 UTC 2014
Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics.
The Journal of biological chemistry
Ahn BJ,Le H,Shin MW,Bae SJ,Lee EJ,Lee SY,Yang JH,Wee HJ,Cha JH,Seo JH,Lee HS,Lee HJ,Arai K,Lo EH,Jeon S,Oh GT,Kim WJ,Ryu JK,Suh JK,Kim KW
Fri Aug 08 00:00:00 UTC 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
Thu Nov 06 00:00:00 UTC 2014
The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.
The Journal of biological chemistry
Yamasaki T,Ariyoshi W,Okinaga T,Adachi Y,Hosokawa R,Mochizuki S,Sakurai K,Nishihara T
Fri Jul 04 00:00:00 UTC 2014
Bipolar/rod-shaped microglia are proliferating microglia with distinct M1/M2 phenotypes.
Scientific reports
Tam WY,Ma CH
Tue Dec 02 00:00:00 UTC 2014
γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages.
The Journal of biological chemistry
Balce DR,Allan ERO,McKenna N,Yates RM
Fri Nov 14 00:00:00 UTC 2014
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
Immunity
Yona S,Kim KW,Wolf Y,Mildner A,Varol D,Breker M,Strauss-Ayali D,Viukov S,Guilliams M,Misharin A,Hume DA,Perlman H,Malissen B,Zelzer E,Jung S
Thu Jan 24 00:00:00 UTC 2013
miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.
Immunity
Sonda N,Simonato F,Peranzoni E,Calì B,Bortoluzzi S,Bisognin A,Wang E,Marincola FM,Naldini L,Gentner B,Trautwein C,Sackett SD,Zanovello P,Molon B,Bronte V
Thu Jun 27 00:00:00 UTC 2013
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
Blood
Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S
Thu Feb 28 00:00:00 UTC 2013
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.
The Journal of clinical investigation
Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW
Tue Jan 01 00:00:00 UTC 2013
The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.
The Journal of experimental medicine
Zou W,Greenblatt MB,Brady N,Lotinun S,Zhai B,de Rivera H,Singh A,Sun J,Gygi SP,Baron R,Glimcher LH,Jones DC
Mon Aug 26 00:00:00 UTC 2013
Identification of human CCR8 as a CCL18 receptor.
The Journal of experimental medicine
Islam SA,Ling MF,Leung J,Shreffler WG,Luster AD
Mon Sep 23 00:00:00 UTC 2013
Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D.
Proceedings of the National Academy of Sciences of the United States of America
Kikuta J,Kawamura S,Okiji F,Shirazaki M,Sakai S,Saito H,Ishii M
Tue Apr 23 00:00:00 UTC 2013
Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Alazawi W,Heath H,Waters JA,Woodfin A,O'Brien AJ,Scarzello AJ,Ma B,Lopez-Otalora Y,Jacobs M,Petts G,Goldin RD,Nourshargh S,Gamero AM,Foster GR
Tue May 21 00:00:00 UTC 2013
E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.
Proceedings of the National Academy of Sciences of the United States of America
Yang Y,Liao B,Wang S,Yan B,Jin Y,Shu HB,Wang YY
Tue Mar 26 00:00:00 UTC 2013
Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription.
Proceedings of the National Academy of Sciences of the United States of America
Liu X,Zhang P,Bao Y,Han Y,Wang Y,Zhang Q,Zhan Z,Meng J,Li Y,Li N,Zhang WJ,Cao X
Tue Jul 02 00:00:00 UTC 2013
Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin.
The Journal of cell biology
Albers J,Keller J,Baranowsky A,Beil FT,Catala-Lehnen P,Schulze J,Amling M,Schinke T
Mon Feb 18 00:00:00 UTC 2013
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.
PLoS pathogens
Lazear HM,Lancaster A,Wilkins C,Suthar MS,Huang A,Vick SC,Clepper L,Thackray L,Brassil MM,Virgin HW,Nikolich-Zugich J,Moses AV,Gale M,Früh K,Diamond MS
Tue Jan 01 00:00:00 UTC 2013
Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity.
Journal of immunology (Baltimore, Md. : 1950)
Moreno C,Prieto P,Macías Á,Pimentel-Santillana M,de la Cruz A,Través PG,Boscá L,Valenzuela C
Sun Dec 15 00:00:00 UTC 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 UTC 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
Sat Jun 15 00:00:00 UTC 2013
Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
Journal of immunology (Baltimore, Md. : 1950)
Ori D,Kato H,Sanjo H,Tartey S,Mino T,Akira S,Takeuchi O
Mon Apr 15 00:00:00 UTC 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
Sat Jun 01 00:00:00 UTC 2013
Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.
Journal of immunology (Baltimore, Md. : 1950)
Kidder D,Richards HE,Ziltener HJ,Garden OA,Crocker PR
Fri Mar 15 00:00:00 UTC 2013
B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Crane DD,Griffin AJ,Wehrly TD,Bosio CM
Fri Mar 15 00:00:00 UTC 2013
A small shared epitope-mimetic compound potently accelerates osteoclast-mediated bone damage in autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fu J,Ling S,Liu Y,Yang J,Naveh S,Hannah M,Gilon C,Zhang Y,Holoshitz J
Sun Sep 01 00:00:00 UTC 2013
Dipterinyl calcium pentahydrate inhibits intracellular mycobacterial growth in human monocytes via the C-C chemokine MIP-1β and nitric oxide.
Infection and immunity
Sakala IG,Eickhoff CS,Blazevic A,Moheno P,Silver RF,Hoft DF
315-02 was used in Cell Culture to indicate that DCP induced mycobacterial killing via MIP-1β- and nitric oxide-dependent effects.
Sat Jun 01 00:00:00 UTC 2013
Osteoblast-targeted overexpression of TAZ increases bone mass in vivo.
PloS one
Yang JY,Cho SW,An JH,Jung JY,Kim SW,Kim SY,Kim JE,Shin CS
Tue Aug 13 00:00:00 UTC 2013
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one
Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M
Fri Sep 27 00:00:00 UTC 2013
CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.
PloS one
Huynh D,Akçora D,Malaterre J,Chan CK,Dai XM,Bertoncello I,Stanley ER,Ramsay RG
Tue Sep 03 00:00:00 UTC 2013
Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.
The Journal of biological chemistry
Kang H,Viollet B,Wu D
Fri Apr 26 00:00:00 UTC 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 UTC 2013
The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus.
PloS one
Sauter KA,Bouhlel MA,O'Neal J,Sester DP,Tagoh H,Ingram RM,Pridans C,Bonifer C,Hume DA
Fri Jul 19 00:00:00 UTC 2013
Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration.
The Journal of biological chemistry
Zhang C,Li Y,Wu Y,Wang L,Wang X,Du J
Fri Jan 18 00:00:00 UTC 2013
Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia.
Journal of neuroinflammation
Gomes C,Ferreira R,George J,Sanches R,Rodrigues DI,Gonçalves N,Cunha RA
Wed Jan 30 00:00:00 UTC 2013
Compensatory dendritic cell development mediated by BATF-IRF interactions.
Nature
Tussiwand R,Lee WL,Murphy TL,Mashayekhi M,KC W,Albring JC,Satpathy AT,Rotondo JA,Edelson BT,Kretzer NM,Wu X,Weiss LA,Glasmacher E,Li P,Liao W,Behnke M,Lam SS,Aurthur CT,Leonard WJ,Singh H,Stallings CL,Sibley LD,Schreiber RD,Murphy KM
Thu Oct 25 00:00:00 UTC 2012
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Nature
Lee GS,Subramanian N,Kim AI,Aksentijevich I,Goldbach-Mansky R,Sacks DB,Germain RN,Kastner DL,Chae JJ
Thu Dec 06 00:00:00 UTC 2012
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Cell
Wang X,Zhang X,Dong XP,Samie M,Li X,Cheng X,Goschka A,Shen D,Zhou Y,Harlow J,Zhu MX,Clapham DE,Ren D,Xu H
Fri Oct 12 00:00:00 UTC 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
Thu Feb 09 00:00:00 UTC 2012
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.
Blood
Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D
Thu Nov 01 00:00:00 UTC 2012
Glucose-6-phosphatase-β, implicated in a congenital neutropenia syndrome, is essential for macrophage energy homeostasis and functionality.
Blood
Jun HS,Cheung YY,Lee YM,Mansfield BC,Chou JY
Thu Apr 26 00:00:00 UTC 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
Thu Oct 11 00:00:00 UTC 2012
Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.
Blood
Rückerl D,Jenkins SJ,Laqtom NN,Gallagher IJ,Sutherland TE,Duncan S,Buck AH,Allen JE
Thu Sep 13 00:00:00 UTC 2012
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.
The Journal of clinical investigation
Kyme P,Thoennissen NH,Tseng CW,Thoennissen GB,Wolf AJ,Shimada K,Krug UO,Lee K,Müller-Tidow C,Berdel WE,Hardy WD,Gombart AF,Koeffler HP,Liu GY
Sat Sep 01 00:00:00 UTC 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 UTC 2012
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
The Journal of experimental medicine
Fang TC,Schaefer U,Mecklenbrauker I,Stienen A,Dewell S,Chen MS,Rioja I,Parravicini V,Prinjha RK,Chandwani R,MacDonald MR,Lee K,Rice CM,Tarakhovsky A
Mon Apr 09 00:00:00 UTC 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 UTC 2012
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.
Proceedings of the National Academy of Sciences of the United States of America
Edris B,Weiskopf K,Volkmer AK,Volkmer JP,Willingham SB,Contreras-Trujillo H,Liu J,Majeti R,West RB,Fletcher JA,Beck AH,Weissman IL,van de Rijn M
Tue Apr 24 00:00:00 UTC 2012
Decreased osteoclastogenesis in serotonin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Chabbi-Achengli Y,Coudert AE,Callebert J,Geoffroy V,Côté F,Collet C,de Vernejoul MC
Tue Feb 14 00:00:00 UTC 2012
Control of bone resorption in mice by Schnurri-3.
Proceedings of the National Academy of Sciences of the United States of America
Wein MN,Jones DC,Shim JH,Aliprantis AO,Sulyanto R,Lazarevic V,Poliachik SL,Gross TS,Glimcher LH
Tue May 22 00:00:00 UTC 2012
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Proceedings of the National Academy of Sciences of the United States of America
Willingham SB,Volkmer JP,Gentles AJ,Sahoo D,Dalerba P,Mitra SS,Wang J,Contreras-Trujillo H,Martin R,Cohen JD,Lovelace P,Scheeren FA,Chao MP,Weiskopf K,Tang C,Volkmer AK,Naik TJ,Storm TA,Mosley AR,Edris B,Schmid SM,Sun CK,Chua MS,Murillo O,Rajendran P,Cha AC,Chin RK,Kim D,Adorno M,Raveh T,Tseng D,Jaiswal S,Enger PØ,Steinberg GK,Li G,So SK,Majeti R,Harsh GR,van de Rijn M,Teng NN,Sunwoo JB,Alizadeh AA,Clarke MF,Weissman IL
Tue Apr 24 00:00:00 UTC 2012
Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
The Journal of cell biology
Kim HJ,Prasad V,Hyung SW,Lee ZH,Lee SW,Bhargava A,Pearce D,Lee Y,Kim HH
Mon Dec 24 00:00:00 UTC 2012
Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins.
PLoS pathogens
Klezovich-Bénard M,Corre JP,Jusforgues-Saklani H,Fiole D,Burjek N,Tournier JN,Goossens PL
Sun Jan 01 00:00:00 UTC 2012
Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.
PLoS pathogens
Skyberg JA,Rollins MF,Holderness JS,Marlenee NL,Schepetkin IA,Goodyear A,Dow SW,Jutila MA,Pascual DW
Mon Jul 09 00:00:00 UTC 2012
The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.
PLoS pathogens
Bebien M,Hensler ME,Davanture S,Hsu LC,Karin M,Park JM,Alexopoulou L,Liu GY,Nizet V,Lawrence T
Tue Jan 29 00:00:00 UTC 2013
Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.
European journal of clinical investigation
Kertész Z,Gyori D,Körmendi S,Fekete T,Kis-Tóth K,Jakus Z,Schett G,Rajnavölgyi E,Dobó-Nagy C,Mócsai A
Sun Jan 01 00:00:00 UTC 2012
Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.
Arthritis research & therapy
Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH
Sun Jan 08 00:00:00 UTC 2012
Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Gaba A,Grivennikov SI,Do MV,Stumpo DJ,Blackshear PJ,Karin M
Sat Sep 01 00:00:00 UTC 2012
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Falanga YT,Chaimowitz NS,Charles N,Finkelman FD,Pullen NA,Barbour S,Dholaria K,Faber T,Kolawole M,Huang B,Odom S,Rivera J,Carlyon J,Conrad DH,Spiegel S,Oskeritzian CA,Ryan JJ
Tue May 01 00:00:00 UTC 2012
Retinoic acid attenuates rheumatoid inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Kwok SK,Park MK,Cho ML,Oh HJ,Park EM,Lee DG,Lee J,Kim HY,Park SH
Sun Jul 15 00:00:00 UTC 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 UTC 2012
Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Tsai CY,Lu SL,Hu CW,Yeh CS,Lee GB,Lei HY
Sun Jan 01 00:00:00 UTC 2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH
Sun Apr 01 00:00:00 UTC 2012
5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1.
Journal of immunology (Baltimore, Md. : 1950)
Lee JM,Park H,Noh AL,Kang JH,Chen L,Zheng T,Lee J,Ji SY,Jang CY,Shin CS,Ha H,Lee ZH,Park HY,Lee DS,Yim M
Sat Dec 01 00:00:00 UTC 2012
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi T,Matsuoka K,Sheikh SZ,Russo SM,Mishima Y,Collins C,deZoeten EF,Karp CL,Ting JP,Sartor RB,Plevy SE
Wed Aug 15 00:00:00 UTC 2012
Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.
Journal of immunology (Baltimore, Md. : 1950)
Deepe GS,Buesing WR
Sun Jan 01 00:00:00 UTC 2012
Activation of the NLRP3 inflammasome by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950)
Costa A,Gupta R,Signorino G,Malara A,Cardile F,Biondo C,Midiri A,Galbo R,Trieu-Cuot P,Papasergi S,Teti G,Henneke P,Mancuso G,Golenbock DT,Beninati C
Wed Feb 15 00:00:00 UTC 2012
Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.
Journal of immunology (Baltimore, Md. : 1950)
Klaas M,Oetke C,Lewis LE,Erwig LP,Heikema AP,Easton A,Willison HJ,Crocker PR
Sat Sep 01 00:00:00 UTC 2012
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gilbert MR,Wagner NJ,Jones SZ,Wisz AB,Roques JR,Krum KN,Lee SR,Nickeleit V,Hulbert C,Thomas JW,Gauld SB,Vilen BJ
Sun Jul 15 00:00:00 UTC 2012
Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection.
Infection and immunity
Chua WJ,Truscott SM,Eickhoff CS,Blazevic A,Hoft DF,Hansen TH
315-02 was used in Cell Culture to uncover the unique innate functions of mucosa-associated invariant T cells in response to bacterial infection.
Sat Sep 01 00:00:00 UTC 2012
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
C5a-regulated CCAAT/enhancer-binding proteins β and δ are essential in Fcγ receptor-mediated inflammatory cytokine and chemokine production in macrophages.
The Journal of biological chemistry
Yan C,Zhu M,Staiger J,Johnson PF,Gao H
Fri Jan 27 00:00:00 UTC 2012
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
The Journal of biological chemistry
Maruyama K,Kawagoe T,Kondo T,Akira S,Takeuchi O
Fri Aug 17 00:00:00 UTC 2012
Inhibition of osteoclastogenesis by RNA interference targeting RANK.
BMC musculoskeletal disorders
Ma R,Xu J,Dong B,Kauther MD,Jäger M,Wedemeyer C
Wed Aug 22 00:00:00 UTC 2012
Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.
PLoS neglected tropical diseases
Rabhi I,Rabhi S,Ben-Othman R,Rasche A,Daskalaki A,Trentin B,Piquemal D,Regnault B,Descoteaux A,Guizani-Tabbane L
Thu Jan 03 00:00:00 UTC 2013
Cofilin activation during podosome belt formation in osteoclasts.
PloS one
Blangy A,Touaitahuata H,Cres G,Pawlak G
Tue May 07 00:00:00 UTC 2013
Decreased autocrine EGFR signaling in metastatic breast cancer cells inhibits tumor growth in bone and mammary fat pad.
PloS one
Nickerson NK,Mohammad KS,Gilmore JL,Crismore E,Bruzzaniti A,Guise TA,Foley J
Mon Jun 04 00:00:00 UTC 2012
CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species.
Journal of neuroinflammation
Yeo YA,Martínez Gómez JM,Croxford JL,Gasser S,Ling EA,Schwarz H
Mon Jul 16 00:00:00 UTC 2012
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
PloS one
Elloumi HZ,Maharshak N,Rao KN,Kobayashi T,Ryu HS,Mühlbauer M,Li F,Jobin C,Plevy SE
Mon Nov 05 00:00:00 UTC 2012
25(OH)D(3) affects the maturation and function of mouse bone marrow-derived dendritic cells stimulated by Mycobacterium bovis BCG.
PloS one
Yang HF,Zhang ZH,Xiang LB,Tang KL,Luo F,Liu CY,Zhou JB,Li JQ,Xu JZ
Thu Apr 25 00:00:00 UTC 2013
Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.
PloS one
Zhuang J,Zhang J,Lwin ST,Edwards JR,Edwards CM,Mundy GR,Yang X
Thu Mar 14 00:00:00 UTC 2013
Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts.
PloS one
Sanchez-Fernandez MA,Sbacchi S,Correa-Tapia M,Naumann R,Klemm J,Chambon P,Al-Robaiy S,Blessing M,Hoflack B
Wed Sep 19 00:00:00 UTC 2012
Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation.
The Journal of biological chemistry
Chiang CY,Veckman V,Limmer K,David M
Fri Feb 03 00:00:00 UTC 2012
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.
Molecular therapy. Nucleic acids
Novobrantseva TI,Borodovsky A,Wong J,Klebanov B,Zafari M,Yucius K,Querbes W,Ge P,Ruda VM,Milstein S,Speciner L,Duncan R,Barros S,Basha G,Cullis P,Akinc A,Donahoe JS,Narayanannair Jayaprakash K,Jayaraman M,Bogorad RL,Love K,Whitehead K,Levins C,Manoharan M,Swirski FK,Weissleder R,Langer R,Anderson DG,de Fougerolles A,Nahrendorf M,Koteliansky V
Tue Jan 24 00:00:00 UTC 2012
Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis.
PloS one
Han YL,Li YL,Jia LX,Cheng JZ,Qi YF,Zhang HJ,Du J
Mon Sep 17 00:00:00 UTC 2012
c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
PloS one
He Y,Rhodes SD,Chen S,Wu X,Yuan J,Yang X,Jiang L,Li X,Takahashi N,Xu M,Mohammad KS,Guise TA,Yang FC
Mon Apr 22 00:00:00 UTC 2013
Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.
PloS one
Eftychi C,Karagianni N,Alexiou M,Apostolaki M,Kollias G
Tue Jul 31 00:00:00 UTC 2012
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.
The Journal of biological chemistry
Toro EJ,Zuo J,Ostrov DA,Catalfamo D,Bradaschia-Correa V,Arana-Chavez V,Caridad AR,Neubert JK,Wronski TJ,Wallet SM,Holliday LS
Fri May 18 00:00:00 UTC 2012
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Nature
Anthony RM,Kobayashi T,Wermeling F,Ravetch JV
Sun Jun 19 00:00:00 UTC 2011
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Immunity
Fukui R,Saitoh S,Kanno A,Onji M,Shibata T,Ito A,Onji M,Matsumoto M,Akira S,Yoshida N,Miyake K
Fri Jul 22 00:00:00 UTC 2011
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.
Immunity
Chae JJ,Cho YH,Lee GS,Cheng J,Liu PP,Feigenbaum L,Katz SI,Kastner DL
Fri May 27 00:00:00 UTC 2011
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.
Immunity
Kuroda E,Ishii KJ,Uematsu S,Ohata K,Coban C,Akira S,Aritake K,Urade Y,Morimoto Y
Fri Apr 22 00:00:00 UTC 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 UTC 2011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
Thu Dec 01 00:00:00 UTC 2011
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
The Journal of experimental medicine
Boldin MP,Taganov KD,Rao DS,Yang L,Zhao JL,Kalwani M,Garcia-Flores Y,Luong M,Devrekanli A,Xu J,Sun G,Tay J,Linsley PS,Baltimore D
Mon Jun 06 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.
Proceedings of the National Academy of Sciences of the United States of America
Martinez J,Almendinger J,Oberst A,Ness R,Dillon CP,Fitzgerald P,Hengartner MO,Green DR
Tue Oct 18 00:00:00 UTC 2011
STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.
PLoS pathogens
Perry ST,Buck MD,Lada SM,Schindler C,Shresta S
Tue Feb 01 00:00:00 UTC 2011
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML
Wed Jun 15 00:00:00 UTC 2011
NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi T,Matsuoka K,Sheikh SZ,Elloumi HZ,Kamada N,Hisamatsu T,Hansen JJ,Doty KR,Pope SD,Smale ST,Hibi T,Rothman PB,Kashiwada M,Plevy SE
Fri Apr 15 00:00:00 UTC 2011
Antibody-mediated "universal" osteoclast targeting platform using calcitonin as a model drug.
Pharmaceutical research
Newa M,Bhandari KH,Tang L,Kalvapalle R,Suresh M,Doschak MR
Sun May 01 00:00:00 UTC 2011
Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication.
Veterinary research
Marshall ES,Elshekiha HM,Hakimi MA,Flynn RJ
Mon Jun 27 00:00:00 UTC 2011
Internal control genes for quantitative RT-PCR expression analysis in mouse osteoblasts, osteoclasts and macrophages.
BMC research notes
Stephens AS,Stephens SR,Morrison NA
Fri Oct 14 00:00:00 UTC 2011
Erk1 positively regulates osteoclast differentiation and bone resorptive activity.
PloS one
He Y,Staser K,Rhodes SD,Liu Y,Wu X,Park SJ,Yuan J,Yang X,Li X,Jiang L,Chen S,Yang FC
Thu Mar 01 00:00:00 UTC 2012
The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
PloS one
Liu S,Madiai F,Hackshaw KV,Allen CE,Carl J,Huschart E,Karanfilov C,Litsky A,Hickey CJ,Marcucci G,Huja S,Agarwal S,Yu J,Caligiuri MA,Wu LC
Thu Mar 03 00:00:00 UTC 2011
IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.
PloS one
Zandian M,Mott KR,Allen SJ,Chen S,Arditi M,Ghiasi H
Fri Feb 18 00:00:00 UTC 2011
Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid.
Proteome science
Choi YJ,Heo SH,Lee JM,Cho JY
Thu Jul 28 00:00:00 UTC 2011
Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.
Respiratory research
Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G
Mon Sep 26 00:00:00 UTC 2011
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
The Journal of biological chemistry
Ehlting C,Ronkina N,Böhmer O,Albrecht U,Bode KA,Lang KS,Kotlyarov A,Radzioch D,Gaestel M,Häussinger D,Bode JG
Fri Jul 08 00:00:00 UTC 2011
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 UTC 2010
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.
Cell
Cheong C,Matos I,Choi JH,Dandamudi DB,Shrestha E,Longhi MP,Jeffrey KL,Anthony RM,Kluger C,Nchinda G,Koh H,Rodriguez A,Idoyaga J,Pack M,Velinzon K,Park CG,Steinman RM
Fri Oct 29 00:00:00 UTC 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 UTC 2010
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity
Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
Wed Nov 24 00:00:00 UTC 2010
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Immunity
Wang L,Gordon RA,Huynh L,Su X,Park Min KH,Han J,Arthur JS,Kalliolias GD,Ivashkiv LB
Fri Apr 23 00:00:00 UTC 2010
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Immunity
Chou RC,Kim ND,Sadik CD,Seung E,Lan Y,Byrne MH,Haribabu B,Iwakura Y,Luster AD
Fri Aug 27 00:00:00 UTC 2010
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Blood
Vemula S,Shi J,Hanneman P,Wei L,Kapur R
Thu Mar 04 00:00:00 UTC 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 UTC 2010
Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.
The Journal of clinical investigation
Lasater EA,Li F,Bessler WK,Estes ML,Vemula S,Hingtgen CM,Dinauer MC,Kapur R,Conway SJ,Ingram DA
Mon Mar 01 00:00:00 UTC 2010
CD14 is a coreceptor of Toll-like receptors 7 and 9.
The Journal of experimental medicine
Baumann CL,Aspalter IM,Sharif O,Pichlmair A,Blüml S,Grebien F,Bruckner M,Pasierbek P,Aumayr K,Planyavsky M,Bennett KL,Colinge J,Knapp S,Superti-Furga G
Mon Nov 22 00:00:00 UTC 2010
Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment.
Proceedings of the National Academy of Sciences of the United States of America
Ahn GO,Tseng D,Liao CH,Dorie MJ,Czechowicz A,Brown JM
Tue May 04 00:00:00 UTC 2010
Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment.
Proceedings of the National Academy of Sciences of the United States of America
Ahn GO,Tseng D,Liao CH,Dorie MJ,Czechowicz A,Brown JM
Tue May 04 00:00:00 UTC 2010
Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens.
PLoS pathogens
Ireland R,Olivares-Zavaleta N,Warawa JM,Gherardini FC,Jarrett C,Hinnebusch BJ,Belisle JT,Fairman J,Bosio CM
Thu May 27 00:00:00 UTC 2010
Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis.
PLoS pathogens
Vadyvaloo V,Jarrett C,Sturdevant DE,Sebbane F,Hinnebusch BJ
Fri Feb 26 00:00:00 UTC 2010
IPS-1 is essential for the control of West Nile virus infection and immunity.
PLoS pathogens
Suthar MS,Ma DY,Thomas S,Lund JM,Zhang N,Daffis S,Rudensky AY,Bevan MJ,Clark EA,Kaja MK,Diamond MS,Gale M
Fri Feb 05 00:00:00 UTC 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 UTC 2010
c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.
Arthritis research & therapy
Paniagua RT,Chang A,Mariano MM,Stein EA,Wang Q,Lindstrom TM,Sharpe O,Roscow C,Ho PP,Lee DM,Robinson WH
Fri Aug 13 00:00:00 UTC 2010
The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Derbigny WA,Johnson RM,Toomey KS,Ofner S,Jayarapu K
Wed Dec 01 00:00:00 UTC 2010
IL-33 exacerbates eosinophil-mediated airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Stolarski B,Kurowska-Stolarska M,Kewin P,Xu D,Liew FY
Wed Sep 15 00:00:00 UTC 2010
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
Journal of immunology (Baltimore, Md. : 1950)
Prantner D,Darville T,Nagarajan UM
Mon Mar 01 00:00:00 UTC 2010
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M
Mon Nov 01 00:00:00 UTC 2010
Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu YY,Sun LC,Wei JJ,Li D,Yuan Y,Yan B,Liang ZH,Zhu HF,Xu Y,Li B,Song CW,Liao SJ,Lei Z,Zhang GM,Feng ZH
Wed Sep 01 00:00:00 UTC 2010
CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Ha J,Choi HS,Lee Y,Kwon HJ,Song YW,Kim HH
Sat May 01 00:00:00 UTC 2010
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Journal of immunology (Baltimore, Md. : 1950)
Foldi J,Chung AY,Xu H,Zhu J,Outtz HH,Kitajewski J,Li Y,Hu X,Ivashkiv LB
Mon Nov 01 00:00:00 UTC 2010
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.
Human molecular genetics
Su N,Sun Q,Li C,Lu X,Qi H,Chen S,Yang J,Du X,Zhao L,He Q,Jin M,Shen Y,Chen D,Chen L
Thu Apr 01 00:00:00 UTC 2010
Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer.
Journal of cellular biochemistry
Bussard KM,Venzon DJ,Mastro AM
Wed Dec 01 00:00:00 UTC 2010
Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.
PloS one
Burnside K,Lembo A,de Los Reyes M,Iliuk A,Binhtran NT,Connelly JE,Lin WJ,Schmidt BZ,Richardson AR,Fang FC,Tao WA,Rajagopal L
Fri Jun 11 00:00:00 UTC 2010
IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration.
PloS one
Urao N,Razvi M,Oshikawa J,McKinney RD,Chavda R,Bahou WF,Fukai T,Ushio-Fukai M
Fri Oct 15 00:00:00 UTC 2010
Determination of the differentiation capacities of murines' primary mononucleated cells and MC3T3-E1 cells.
Cancer cell international
Yazid MD,Ariffin SHZ,Senafi S,Razak MA,Wahab RMA
Thu Oct 28 00:00:00 UTC 2010
Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.
PLoS genetics
Mauer J,Chaurasia B,Plum L,Quast T,Hampel B,Blüher M,Kolanus W,Kahn CR,Brüning JC
Thu May 06 00:00:00 UTC 2010
Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice.
The Journal of biological chemistry
Dejager L,Pinheiro I,Puimège L,Fan YD,Gremeaux L,Vankelecom H,Libert C
Fri Oct 01 00:00:00 UTC 2010
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
PloS one
Akagi T,Thoennissen NH,George A,Crooks G,Song JH,Okamoto R,Nowak D,Gombart AF,Koeffler HP
Wed Nov 03 00:00:00 UTC 2010
Direct cell reprogramming is a stochastic process amenable to acceleration.
Nature
Hanna J,Saha K,Pando B,van Zon J,Lengner CJ,Creyghton MP,van Oudenaarden A,Jaenisch R
Thu Dec 03 00:00:00 UTC 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 UTC 2009
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Immunity
Meng G,Zhang F,Fuss I,Kitani A,Strober W
Fri Jun 19 00:00:00 UTC 2009
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Blood
Fang HY,Hughes R,Murdoch C,Coffelt SB,Biswas SK,Harris AL,Johnson RS,Imityaz HZ,Simon MC,Fredlund E,Greten FR,Rius J,Lewis CE
Thu Jul 23 00:00:00 UTC 2009
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.
Blood
Steimer DA,Boyd K,Takeuchi O,Fisher JK,Zambetti GP,Opferman JT
Thu Mar 19 00:00:00 UTC 2009
CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice.
The Journal of clinical investigation
Menke J,Iwata Y,Rabacal WA,Basu R,Yeung YG,Humphreys BD,Wada T,Schwarting A,Stanley ER,Kelley VR
Sat Aug 01 00:00:00 UTC 2009
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
The Journal of experimental medicine
Kubo T,Uchida Y,Watanabe Y,Abe M,Nakamura A,Ono M,Akira S,Takai T
Mon Aug 31 00:00:00 UTC 2009
Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.
The EMBO journal
Florence WC,Xia C,Gordy LE,Chen W,Zhang Y,Scott-Browne J,Kinjo Y,Yu KO,Keshipeddy S,Pellicci DG,Patel O,Kjer-Nielsen L,McCluskey J,Godfrey DI,Rossjohn J,Richardson SK,Porcelli SA,Howell AR,Hayakawa K,Gapin L,Zajonc DM,Wang PG,Joyce S
Wed Nov 18 00:00:00 UTC 2009
Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
Proceedings of the National Academy of Sciences of the United States of America
Inui M,Kikuchi Y,Aoki N,Endo S,Maeda T,Sugahara-Tobinai A,Fujimura S,Nakamura A,Kumanogoh A,Colonna M,Takai T
Tue Mar 24 00:00:00 UTC 2009
Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells.
The Journal of investigative dermatology
Hsu DK,Chernyavsky AI,Chen HY,Yu L,Grando SA,Liu FT
Sun Mar 01 00:00:00 UTC 2009
Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
PLoS pathogens
Daffis S,Suthar MS,Szretter KJ,Gale M,Diamond MS
Thu Oct 01 00:00:00 UTC 2009
NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.
Journal of immunology (Baltimore, Md. : 1950)
Wang D,Paz-Priel I,Friedman AD
Fri May 01 00:00:00 UTC 2009
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R
Sun Feb 15 00:00:00 UTC 2009
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.
Journal of immunology (Baltimore, Md. : 1950)
Ji JD,Park-Min KH,Shen Z,Fajardo RJ,Goldring SR,McHugh KP,Ivashkiv LB
Tue Dec 01 00:00:00 UTC 2009
Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion.
Journal of immunology (Baltimore, Md. : 1950)
Deuretzbacher A,Czymmeck N,Reimer R,Trülzsch K,Gaus K,Hohenberg H,Heesemann J,Aepfelbacher M,Ruckdeschel K
Sun Nov 01 00:00:00 UTC 2009
Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.
Journal of immunology (Baltimore, Md. : 1950)
Casbon AJ,Allen LA,Dunn KW,Dinauer MC
Sun Feb 15 00:00:00 UTC 2009
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.
Journal of immunology (Baltimore, Md. : 1950)
Park-Min KH,Ji JD,Antoniv T,Reid AC,Silver RB,Humphrey MB,Nakamura M,Ivashkiv LB
Sat Aug 15 00:00:00 UTC 2009
A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.
Journal of immunology (Baltimore, Md. : 1950)
Crane DD,Warner SL,Bosio CM
Thu Oct 01 00:00:00 UTC 2009
Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kiesel JR,Buchwald ZS,Aurora R
Fri May 01 00:00:00 UTC 2009
Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.
The Journal of biological chemistry
Timmer AM,Timmer JC,Pence MA,Hsu LC,Ghochani M,Frey TG,Karin M,Salvesen GS,Nizet V
Fri Jan 09 00:00:00 UTC 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
Tue Nov 24 00:00:00 UTC 2009
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone.
The Journal of biological chemistry
Lu X,Kang Y
Fri Oct 16 00:00:00 UTC 2009
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature
Saitoh T,Fujita N,Jang MH,Uematsu S,Yang BG,Satoh T,Omori H,Noda T,Yamamoto N,Komatsu M,Tanaka K,Kawai T,Tsujimura T,Takeuchi O,Yoshimori T,Akira S
Thu Nov 13 00:00:00 UTC 2008
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Immunity
Hu X,Chung AY,Wu I,Foldi J,Chen J,Ji JD,Tateya T,Kang YJ,Han J,Gessler M,Kageyama R,Ivashkiv LB
Fri Nov 14 00:00:00 UTC 2008
Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.
Blood
McGrath KE,Kingsley PD,Koniski AD,Porter RL,Bushnell TP,Palis J
Fri Feb 15 00:00:00 UTC 2008
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.
The Journal of clinical investigation
Aliprantis AO,Ueki Y,Sulyanto R,Park A,Sigrist KS,Sharma SM,Ostrowski MC,Olsen BR,Glimcher LH
Sat Nov 01 00:00:00 UTC 2008
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.
Proceedings of the National Academy of Sciences of the United States of America
Chiu IM,Chen A,Zheng Y,Kosaras B,Tsiftsoglou SA,Vartanian TK,Brown RH,Carroll MC
Tue Nov 18 00:00:00 UTC 2008
Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Jennewein C,Kuhn AM,Schmidt MV,Meilladec-Jullig V,von Knethen A,Gonzalez FJ,Brüne B
Wed Oct 15 00:00:00 UTC 2008
Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family.
Journal of immunology (Baltimore, Md. : 1950)
Grigat J,Soruri A,Forssmann U,Riggert J,Zwirner J
Sat Sep 15 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
The Journal of biological chemistry
Zhu J,Jia X,Xiao G,Kang Y,Partridge NC,Qin L
Fri Sep 14 00:00:00 UTC 2007
Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Park H,Jung YK,Park OJ,Lee YJ,Choi JY,Choi Y
Thu Dec 01 00:00:00 UTC 2005
TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950)
Andrade RM,Wessendarp M,Portillo JA,Yang JQ,Gomez FJ,Durbin JE,Bishop GA,Subauste CS
Tue Nov 01 00:00:00 UTC 2005
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
