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          • Proteins & Peptides ›
          • TRAIL (CD253) Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Mouse TRAIL (TNFSF10) Recombinant Protein, PeproTech®

          11 References
          View all (6) TRAIL (CD253) proteins

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          Datasheet
          Tech Support
          Datasheet
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          Cite Mouse TRAIL (TNFSF10) Recombinant Protein, PeproTech®

          Product Details

          315-19-50UG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          ELISA (ELISA)

          Assay-dependent
          -

          Functional Assay (Functional)

          Assay-dependent
          -

          In vitro Assay (IV)

          -
          View 6 publications 6 publications

          Miscellaneous PubMed (MISC)

          -
          View 5 publications 5 publications
          Product Specifications

          Species

          Mouse

          Published species

          Human, Mouse

          Expression System

          E. coli

          Amino acid sequence

          MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN

          Molecular weight

          20 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥ 95% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Assay 1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml. Assay 2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0 ng/ml.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          Recombinant Murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF-homologous portion of the extracellular domain of the full length TRAIL protein.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CD253; CD253 antigen; Protein TRAIL; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand; TRAIL protein; TRAIL/APO2L; Tumor necrosis factor ligand superfamily member 10

          View more View less

          Gene Aliases: A330042I21Rik; AI448571; APO-2L; Ly81; TL2; Tnfsf10; Trail

          View more View less

          UniProt ID: (Mouse) P50592

          View more View less

          Entrez Gene ID: (Mouse) 22035

          View more View less

          It has to be done as per old AB suggested Products section.
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