GUCY1A3 Antibodies

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Synonyms

1200016O07Rik; 4.6.1.2; alpha 1 sGC; GC-SA3; GCSalpha1; GC-S-alpha-1; GCS-alpha1; GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); GUC1A3; GUCA3; GUCSA3; Gucy1a1; GUCY1A3; MYMY6; SGC; sGC-alpha1; soluble guanylate cyclase large subunit