PSMD3 Antibodies

Target Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.

Synonyms

26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; AI255837; AntP91a; D11Bwg1349e; P58; P91a; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; proteasome 26S non-ATPase subunit 3; proteasome 26S subunit, non-ATPase 3; proteasome subunit p58; Psd3; PSMD3; RPN3; S3; tissue specific transplantation antigen 2; tissue specific transplantation antigen P91A; Transplantation antigen P91A; TSTA2; Tstap91a; Tum-P91A antigen