RNF168 Antibodies

Antibodies that detect RNF168 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. These antibodies target RNF168 in Human and Mouse samples. Our RNF168 polyclonal and monoclonal antibodies are... Antibodies that detect RNF168 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. These antibodies target RNF168 in Human and Mouse samples. Our RNF168 polyclonal and monoclonal antibodies are developed in Rabbit and... Antibodies that detect RNF168 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. These antibodies target RNF168 in Human and Mouse samples. Our RNF168 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. Find the RNF168 antibody that fits your needs. Choose from 1 of 10 RNF168 antibodies, which have been validated in experiments with 7 publications and 22 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot... Antibodies that detect RNF168 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. These antibodies target RNF168 in Human and Mouse samples. Our RNF168 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. Find the RNF168 antibody that fits your needs. Choose from 1 of 10 RNF168 antibodies, which have been validated in experiments with 7 publications and 22 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.

Synonyms

3110001H15Rik; E3 ubiquitin-protein ligase RNF168; FLJ35794; hRNF168; RING finger protein 168; ring finger protein 168, E3 ubiquitin protein ligase; ring fnger protein 168; RING-type E3 ubiquitin transferase RNF168; RNF168

RNF168 Antibodies

Target Information

Synonyms

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