Bioss

14-3-3 Alpha/Beta/Gamma/Delta/Epsilon Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-0237R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Yeast

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human 14-3-3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14-3-3 alpha; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3 protein epsilon; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma-subtype; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 tau; 14-3-3 theta; 14-3-3 zeta; 14-3-3E; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; brain protein 14-3-3, beta isoform; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; KCIP-1; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; Mitochondrial import stimulation factor S1 subunit; MSF L; phospholipase A2; Prepronerve growth factor RNH-1; Protein 1054; Protein HS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein, theta; SEZ-2; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide

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Gene Aliases: 1110013I11Rik; 1300003C17Rik; 14-3-3; 14-3-3-zeta; 14-3-3E; 14-3-3G; 14-3-3GAMMA; 14-3-3t; 14-3-3z; 14-3-3zeta; 1C5; 2700028P07Rik; AA409740; AI596267; AL022924; AU019196; AU020854; AU021156; D7Bwg1348e; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL2; HEL4; HS1; KCIP-1; MDCR; MDS; Msfs1; PPP1R170; R74690; YWHAA; YWHAB; YWHAD; YWHAE; YWHAG; YWHAQ; YWHAZ

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UniProt ID: (Human) P31946, (Human) P62258, (Human) P61981, (Human) P27348, (Human) P63104, (Mouse) Q9CQV8, (Rat) P35213, (Rat) P62260, (Mouse) P62259, (Mouse) P61982, (Rat) P61983, (Rat) P68255, (Mouse) P68254, (Mouse) P63101, (Rat) P63102

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Entrez Gene ID: (Human) 7529, (Human) 7531, (Human) 7532, (Human) 10971, (Human) 7534, (Mouse) 54401, (Rat) 56011, (Rat) 29753, (Mouse) 22627, (Mouse) 22628, (Rat) 56010, (Rat) 25577, (Mouse) 22630, (Mouse) 22631, (Rat) 25578

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Function(s)
transcription corepressor activity protein binding protein C-terminus binding enzyme binding protein domain specific binding protein complex binding histone deacetylase binding phosphoserine binding phosphoprotein binding cadherin binding involved in cell-cell adhesion potassium channel regulator activity MHC class II protein complex binding ubiquitin protein ligase binding ion channel binding poly(A) RNA binding protein heterodimerization activity protein kinase C binding insulin-like growth factor receptor binding protein kinase C inhibitor activity receptor tyrosine kinase binding protein N-terminus binding 14-3-3 protein binding transcription factor binding protein kinase binding identical protein binding actin binding enzyme regulator activity
Process(es)
histamine secretion by mast cell protein targeting protein targeting to mitochondrion regulation of cell death response to drug establishment of Golgi localization Golgi reassembly small GTPase mediated signal transduction substantia nigra development negative regulation of ion transmembrane transport negative regulation of transcription, DNA-templated neuron migration signal transduction hippocampus development cerebral cortex development negative regulation of protein dephosphorylation regulation of membrane repolarization negative regulation of protein serine/threonine kinase activity regulation of potassium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation positive regulation of catalytic activity cytoplasmic sequestering of protein protein heterooligomerization cellular response to insulin stimulus regulation of neuron differentiation regulation of synaptic plasticity membrane organization positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway platelet activation negative regulation of apoptotic process regulation of mRNA stability cell-cell adhesion regulation of catalytic activity G2/M transition of mitotic cell cycle regulation of heart rate by hormone viral process hippo signaling intracellular signal transduction negative regulation of cysteine-type endopeptidase activity involved in apoptotic process membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of cellular response to heat negative regulation of protein kinase activity regulation of signal transduction MAPK cascade negative regulation of G-protein coupled receptor protein signaling pathway
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