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NeoBiotechnologies
14-3-3E/Tryptophan 5-Monooxygenase Monoclonal Antibody (CPTC-YWHAE-1)
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Product Details
7531-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-YWHAE-1
Immunogen
Recombinant human full-length YWHAE protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
14-3-3 epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; epididymis luminal protein 2; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
Gene Aliases: 14-3-3E; HEL2; KCIP-1; MDCR; MDS; YWHAE
UniProt ID: (Human) P62258
Entrez Gene ID: (Human) 7531
protein binding
potassium channel regulator activity
enzyme binding
protein domain specific binding
MHC class II protein complex binding
ubiquitin protein ligase binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
protein heterodimerization activity
phosphoserine binding
phosphoprotein binding
cadherin binding involved in cell-cell adhesion
G2/M transition of mitotic cell cycle
neuron migration
regulation of heart rate by hormone
protein targeting
viral process
substantia nigra development
hippocampus development
cerebral cortex development
hippo signaling
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of membrane repolarization
membrane organization
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
cell-cell adhesion
regulation of cellular response to heat
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of potassium ion transmembrane transporter activity
negative regulation of peptidyl-serine dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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