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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5-HT 2B receptor; 5-HT-1C; 5-HT-2; 5-HT-2A; 5-HT-2B; 5-HT-2C; 5-HT-2F; 5-HT1C; 5-HT2 receptor; 5-HT2A receptor; 5-HT2B; 5-HT2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5-hydroxytryptamine receptor 2C; NP75 protein; serotonin 1c receptor; serotonin 5-HT-1C receptor; serotonin 5-HT-2A receptor; serotonin 5-HT-2C receptor; serotonin 5HT-2 receptor; Serotonin receptor 2A; Serotonin receptor 2B; Serotonin receptor 2C; Stomach fundus serotonin receptor
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT1C; 5-HT2A; 5-HT2B; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT-1C; 5Ht-2; 5HT1c; 5HTR2C; AJ012488; AV377389; E030013E04; Htr-2; HTR1C; HTR2; HTR2A; HTR2B; HTR2C; SR1; Srl
UniProt ID: (Human) P28223, (Human) P41595, (Human) P28335, (Mouse) P35363, (Rat) P14842, (Mouse) Q02152, (Rat) P30994, (Rat) P08909, (Mouse) P34968
Entrez Gene ID: (Human) 3356, (Human) 3357, (Human) 3358, (Mouse) 15558, (Rat) 29595, (Mouse) 15559, (Rat) 29581, (Rat) 25187, (Mouse) 15560
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