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5HT2B R Polyclonal Antibody

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View all (14) HTR2B antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSS00420W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 390-440 of mouse 5HT2B receptor conjugated to blue carrier protein was used as the antigen
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide shares 92% identity with human sequence and 82% with rat.

Specificity of this antibody: 5HT2B receptor.

Target Information

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5-HT-2B; 5-HT-2F; 5-HT2b receptor; 5-hydroxytryptamine receptor 2B; 5HT2B Receptor; NP75 protein; Serotonin receptor 2B

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Gene Aliases: 5-HT2B; AJ012488; AV377389; Htr2b

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UniProt ID: (Mouse) Q02152

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Entrez Gene ID: (Mouse) 15559

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Function(s)
G-protein alpha-subunit binding signal transducer activity G-protein coupled receptor activity G-protein coupled serotonin receptor activity GTPase activator activity drug binding serotonin binding
Process(es)
neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy cGMP biosynthetic process cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway heart development behavior positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction phosphorylation calcium-mediated signaling ion transmembrane transport vasoconstriction response to drug negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin
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