Alomone Labs, LTD

5HT2B Receptor (HTR2B) (extracellular) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ASR-035-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

1:400
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KMSEQ STISEHILQK, corresponding to amino acid residues 6-20 of rat 5-Hydroxytryptamine receptor 2B, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT-2F; 5-HT2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; NP75 protein; Serotonin receptor 2B; Stomach fundus serotonin receptor

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Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; AJ012488; AV377389; HTR2B; Srl

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UniProt ID: (Human) P41595, (Mouse) Q02152, (Rat) P30994

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Entrez Gene ID: (Human) 3357, (Mouse) 15559, (Rat) 29581

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Function(s)
G-protein alpha-subunit binding G-protein coupled serotonin receptor activity GTPase activator activity drug binding serotonin binding signal transducer activity G-protein coupled receptor activity protein binding
Process(es)
neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy cGMP biosynthetic process cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway heart development behavior positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction phosphorylation calcium-mediated signaling ion transmembrane transport vasoconstriction response to drug negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin hepatic stellate cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling inositol phosphate metabolic process
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