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Alomone Labs, LTD
5HT7 Receptor/HTR7 (extracellular) Polyclonal Antibody, FITC
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FIGURE: 1 / 2
5HT7 Receptor/HTR7 (extracellular) Antibody (ASR-037-F-50UL) in Flow
Cell surface detection of 5HT7 Receptor by direct flow cytometry in live intact human MEG-01 megakaryoblastic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-5HT7 Receptor/HTR7 (extracellular)-FITC Antibody (#ASR-037-F), (5 µg).
Product Details
ASR-037-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide CGEQINYGRVEK, corresponding to amino acid residues 73-84 of rat 5-HT7, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine receptor 7; 5HT7 Receptor; GPRFO; high affinity serotonin receptor (5HT7); HT7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; Serotonin receptor 7
Gene Aliases: 5-HT7; 5Ht7; HTR7
UniProt ID: (Human) P34969, (Mouse) P32304, (Rat) P32305
Entrez Gene ID: (Human) 3363, (Mouse) 15566, (Rat) 65032
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
memory
circadian rhythm
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
vasoconstriction
negative regulation of circadian sleep/wake cycle, REM sleep
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
micturition
long-term synaptic potentiation
dopaminergic neuron differentiation
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
response to electrical stimulus
blood circulation
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