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Bioss
8-OHdG/8 Hydroxyguanosine Polyclonal Antibody
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Product Details
BS-1278R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated 8-OhdG.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Oxygen is necessary for aerobic life, it can also participate in potentially toxic reactions involving oxygen free radicals and transition metals such as iron that damage membranes, proteins, and nucleic acids. n a normal human cell, there is a steady accumulation of DNA lesions with time. Substantial parts of these lesions are due to endogenous factors that damage DNA. These include reactive oxygens pecies derived from oxidative respiration. Additionally, malignant cells can produce hydrogen peroxide at levels as high as those characteristics for stimulated polymorphonuclear leukocytes. Some tumors may stimulate the defense systems of the body so that they react against the tumor to produce cytokines. Some cytokines can produce large amounts of ROS. 8-OHdG is one of the most widely studied lesions of this type. The presenceof 8-OHdG residues in DNA leads to GC to TA transversion unless repairs are made before DNA replication. Therefore, the presence of 8-OHdG may lead to mutagenesis. Furthermore, many observations indicate a direct correlation between 8-OHdG formation and carcinogenesis in vivo. It is generally accepted that the repair products of cellular DNA, for example 8-OHdG, are excreted into the urine without further metabolism. Therefore, 8-OHdG has been proposed as a urinary biomarker for in vivo oxidative DNA lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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