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Invitrogen
90K/Mac-2BP Monoclonal Antibody (SP-2), eBioscience™
FIGURE: 1 / 2
90K/Mac-2BP Antibody (BMS146) in IHC (PFA)
Nature communications 2021 -
Fig. 1 LGALS3BP expression in human cortical progenitors. a Bulk RNA-sequencing data performed in COs at different stages. LGALS3BP has a peak of expression after apical progenitor marker PAX6 and prior to basal progenitor markers EOMES and HOPX . Data are shown as mean +- SEM, batches = 3, organoids = 3. Statistical analysis was performed using two-way ANOVA followed by Tukey's multiple comparison test, &a... View More
Product Details
BMS146
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
SP-2
Immunogen
Rec. Human Mac-2BP
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2-7.4
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10598353
Product Specific Information
Description: BMS146 specifically recognizes Mac-2 (galectin-3) mucin-like binding domain of human 90K/Mac-2BP. Mac-2BP is a highly glycosylated protein that plays a major role in cancer research. Elevated levels in sera have been found in many patients suffering from various types of cancer or viral infections.
Applications Tested: Immunohistochemistry (Paraffin), Western Blotting.
Purity: >95%.
Target Information
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Basement membrane autoantigen p105; Galectin-3-binding protein; L3 antigen; Lectin; lectin galactoside-binding soluble 3 binding protein; Lectin galactoside-binding soluble 3-binding protein; lectin, galactoside binding soluble 3 binding protein; lectin, galactoside-binding, soluble, 3 binding protein; mac-2 BP; Mac-2-binding protein; MAC2BP; serum protein 90K; transport and golgi organization 10 homolog B; Tumor-associated antigen 90K
Gene Aliases: 90K; BTBD17B; CyCAP; gp90; LGALS3BP; M2BP; MAC-2-BP; TANGO10B
UniProt ID: (Human) Q08380
Entrez Gene ID: (Human) 3959
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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