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Invitrogen
ABCA1 Monoclonal Antibody (3A1.891.3)
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FIGURE: 1 / 6
ABCA1 Antibody (MA1-16936) in ICC/IF
Immunofluorescence analysis of ABCA1 was performed using log phase THP-1 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with ABCA1 Monoclonal Antibody (3A1.891.3) (Product # MA1-16936) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then with Goat anti-Rat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 (Product # A-11006) at a dilution of 1:2000 f... View More
Product Details
MA1-16936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3A1.891.3
Immunogen
Synthetic peptide corrseponding to the N-terminal loop residues 200-250 of mouse ABCA1.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_779127
Product Specific Information
This antibody does not react with human ABCA1.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC 1; ABC 1 antibody; ABC Transporter 1; ABC-1; ABC1 antibody; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; CERP antibody; Phospholipid-transporting ATPase ABCA1
Gene Aliases: ABC-1; Abc1; Abca1
UniProt ID: (Mouse) P41233
Entrez Gene ID: (Mouse) 11303
nucleotide binding
receptor binding
transporter activity
protein binding
ATP binding
phospholipid transporter activity
anion transmembrane transporter activity
ATPase activity
cholesterol transporter activity
syntaxin binding
small GTPase binding
apolipoprotein binding
apolipoprotein A-I binding
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
ATPase binding
peptide secretion
protein lipidation
transport
phagocytosis, engulfment
lysosome organization
G-protein coupled receptor signaling pathway
cholesterol metabolic process
positive regulation of cholesterol efflux
phospholipid transport
endosomal transport
cholesterol transport
positive regulation of cAMP biosynthetic process
intracellular cholesterol transport
regulation of Cdc42 protein signal transduction
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
apolipoprotein A-I-mediated signaling pathway
lipoprotein metabolic process
lipoprotein biosynthetic process
cholesterol homeostasis
reverse cholesterol transport
phospholipid translocation
interleukin-1 beta secretion
transmembrane transport
phospholipid homeostasis
response to high density lipoprotein particle
platelet dense granule organization
cellular response to lipopolysaccharide
cellular response to retinoic acid
anion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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