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Invitrogen
ABCA7 Monoclonal Antibody (7A1-144)
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FIGURE: 1 / 5
ABCA7 Antibody (MA5-24784) in WB
Western blot analysis of ABCA7 in mouse platelets. Samples were incubated in ABCA7 monoclonal antibody (Product # MA5-24784) using a dilution of 0.5 µg/mL followed by an anti-rat HRP secondary antibody. Separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. Detection: chemiluminescence.
Product Details
MA5-24784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
7A1-144
Immunogen
Mouse ABCA7 stably-transfected HeLa cells.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2717257
Target Information
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ATP-binding cassette sub-family A member 7; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025
Gene Aliases: Abc51; Abca7; ABCX
UniProt ID: (Mouse) Q91V24
Entrez Gene ID: (Mouse) 27403
transport
phagocytosis
memory
positive regulation of cholesterol efflux
phospholipid scrambling
peptide cross-linking
negative regulation of ATPase activity
positive regulation of ATPase activity
cholesterol efflux
phospholipid efflux
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
positive regulation of phagocytosis
transmembrane transport
positive regulation of ERK1 and ERK2 cascade
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
positive regulation of phospholipid efflux
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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