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Product Details
OSC00244W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 20-70 of mouse ABCC7 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and shares 95% with human sequence.
Specificity of this antibody: ABCC7.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; cAMP-dependent chloride channel; CFTR; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7; tcag7.78; TNR CFTR
Gene Aliases: Abcc7; AW495489; Cftr; RGD1561193
UniProt ID: (Mouse) P26361, (Rat) P34158
Entrez Gene ID: (Mouse) 12638, (Rat) 24255
nucleotide binding
chloride channel activity
channel-conductance-controlling ATPase activity
protein binding
ATP binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
hydrolase activity
ATPase activity
chloride channel inhibitor activity
enzyme binding
PDZ domain binding
ATPase activity, coupled to transmembrane movement of substances
molecular_function
cholesterol biosynthetic process
transport
ion transport
chloride transport
water transport
bicarbonate transport
iodide transport
cholesterol transport
transepithelial chloride transport
lung development
vasodilation
positive regulation of vasodilation
sperm capacitation
intracellular pH elevation
transmembrane transport
membrane hyperpolarization
cellular response to cAMP
chloride transmembrane transport
positive regulation of voltage-gated chloride channel activity
body fluid secretion
cellular response to hormone stimulus
response to cytokine
response to drug
response to peptide hormone
response to estrogen
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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