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Invitrogen
ABCD4 Polyclonal Antibody
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FIGURE: 1 / 2
ABCD4 Antibody (PA5-75480) in IHC (P)
Immunohistochemistry analysis of ABCD4 in paraffin-embedded human kidney carcinoma tissue (peroxisome membrane staining) and negative control (right, with PBS only). Samples were incubated with ABCD4 polyclonal antibody (Product # PA5-75480) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75480
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 157-202 of Human ABCD4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719208
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1-4 that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter. A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder which affects lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD. The peroxisomal membrane comprises two quantitatively major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from the mitochondria to the cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 69 kDa peroxisomal ABC-transporter; ATP-binding cassette sub-family D member 4; ATP-binding cassette, sub-family D (ALD), member 4; ATP-binding cassette, sub-family D, member 4; Lysosomal cobalamin transporter ABCD4; P70R; Peroxisomal membrane protein 1-like; Peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related; PMP69; PMP70-related protein; PXMP1-L
Gene Aliases: ABC41; ABCD4; EST352188; MAHCJ; P69r; P70R; P79R; PMP69; PXMP1L
UniProt ID: (Human) O14678, (Mouse) O89016
Entrez Gene ID: (Human) 5826, (Mouse) 19300, (Rat) 299196
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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