Proteintech

ABCG5 Polyclonal Antibody

ABCG5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ABCG5 Antibody (27722-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 27722-1-AP (ABCG5 antibody) at dilution of 1:200 (under 40x lens).

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Product Details

27722-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 23 publications 23 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ABCG5 Fusion Protein Ag26844 (1-85 aa encoded by NM_022436)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGDLSSLTP GGSMGLQVNR GSQSSLEGAP ATAPEPHSLG ILHASYSVSH RVRPWWDITS CRQQWTRQIL KDVSLYVESG QIMCIL (1-85 aa encoded by NM _022436)

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice.

bioRxiv : the preprint server for biology

Li Z,He M,Chen G,Worgall TS,Jiang XC

Tue Feb 07 00:00:00 UTC 2023

Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis.

Diabetes

Shen X,Zhang Y,Ji X,Li B,Wang Y,Huang Y,Zhang X,Yu J,Zou R,Qin D,Zhou H,Wang Q,Li JZ

Thu Sep 01 00:00:00 UTC 2022

Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.

International journal of endocrinology

Yuefeng Y,Zhiqi L,Yi C,Keyu Z,Heng W,Yuying W,Ningjian W,Yuetian Y,Xinjie G,Yihao Z,Yingli L,Fangzhen X

Sat Jul 16 00:00:00 UTC 2022

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.

Nature

Wang JQ,Li LL,Hu A,Deng G,Wei J,Li YF,Liu YB,Lu XY,Qiu ZP,Shi XJ,Zhao X,Luo J,Song BL

Mon Aug 01 00:00:00 UTC 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 UTC 2022

Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids.

Frontiers in medicine

Zhuang Q,Cheng J,Xia J,Ning M,Wu S,Shen S,Shi Y,Huang D,Dong Z,Wan X

Sat Apr 23 00:00:00 UTC 2022

Preparation of microgel co-loaded with nuciferine and epigallocatechin-3-gallate for the regulation of lipid metabolism.

Frontiers in nutrition

Zhu S,Xu W,Liu J,Guan F,Xu A,Zhao J,Ge J

Tue Jan 03 00:00:00 UTC 2023

Alisol B 23-acetate adjusts bile acid metabolisim via hepatic FXR-BSEP signaling activation to alleviate atherosclerosis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Fu Y,Feng H,Ding X,Meng QH,Zhang SR,Li J,Chao Y,Ji TT,Bi YH,Zhang WW,Chen Q,Zhang YH,Feng YL,Bian HM

Fri Jul 01 00:00:00 UTC 2022

Di(2-ethylhexyl) phthalate disturbs cholesterol metabolism through oxidative stress in rat liver.

Environmental toxicology and pharmacology

Li G,Zhao CY,Wu Q,Kang Z,Zhang JT,Guan SY,Jin HW,Zhang YB,Na XL

Sat Oct 01 00:00:00 UTC 2022

Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells.

Nutrients

Huang Y,Tocmo R,Nauman MC,Haughan MA,Johnson JJ

Fri Sep 10 00:00:00 UTC 2021

miRNA-223 Suppresses Mouse Gallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway.

International journal of biological sciences

Zhao F,Ma S,Zhou Y,Wei B,Hao Z,Cui X,Xing L,Liu G,Jin L,Ma T,Shi L

Mon Dec 20 00:00:00 UTC 2021

Resveratrol enhances trans-intestinal cholesterol excretion through selective activation of intestinal liver X receptor alpha.

Biochemical pharmacology

Pang J,Xu H,Wang X,Chen X,Li Q,Liu Q,You Y,Zhang H,Xu Z,Zhao Y,Zhang Y,Yang Y,Ling W

Thu Apr 01 00:00:00 UTC 2021

HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.

Molecular therapy. Nucleic acids

Zhang Z,Wen H,Peng B,Weng J,Zeng F

Fri Jun 04 00:00:00 UTC 2021

A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Cellular and molecular gastroenterology and hepatology

Sun D,Niu Z,Zheng HX,Wu F,Jiang L,Han TQ,Wei Y,Wang J,Jin L

Mon Mar 07 00:00:00 UTC 2022

Astragalus Polysaccharides Ameliorate Diet-Induced Gallstone Formation by Modulating Synthesis of Bile Acids and the Gut Microbiota.

Frontiers in pharmacology

Zhuang Q,Ye X,Shen S,Cheng J,Shi Y,Wu S,Xia J,Ning M,Dong Z,Wan X

Tue Jul 20 00:00:00 UTC 2021

Ezetimibe promotes CYP7A1 and modulates PPARs as a compensatory mechanism in LDL receptor-deficient hamsters.

Lipids in health and disease

Xia B,Lin P,Ji Y,Yin J,Wang J,Yang X,Li T,Yang Z,Li F,Guo S

Sat Feb 08 00:00:00 UTC 2020

Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats.

Nutrients

Li S,Xu S,Zhao Y,Wang H,Feng J

Wed May 13 00:00:00 UTC 2020

The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.

Journal of cellular and molecular medicine

Li T,Hu SM,Pang XY,Wang JF,Yin JY,Li FH,Wang J,Yang XQ,Xia B,Liu YH,Song WG,Guo SD

Sun Mar 01 00:00:00 UTC 2020

Protective effects of L-theanine on rats with dextran sulfate sodium-induced inflammatory bowel disease.

Archives of pharmacal research

Chen L,Xiao WJ,Yan QX,Gong ZH,Zhang S,Zeng L,Yang M,Zhou YH

Sat Aug 01 00:00:00 UTC 2020

Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.

Journal of agricultural and food chemistry

Yang Z,Liu G,Wang Y,Yin J,Wang J,Xia B,Li T,Yang X,Hou P,Hu S,Song W,Guo S

Wed May 22 00:00:00 UTC 2019

Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.

Biochemical and biophysical research communications

Yang S,Wei L,Xia R,Liu L,Chen Y,Zhang W,Li Q,Feng K,Yu M,Zhang W,Qu J,Xu S,Mao J,Fan G,Ma C

Tue May 14 00:00:00 UTC 2019

Oral Administration of Succinoglycan Riclin Improves Diet-Induced Hypercholesterolemia in Mice.

Journal of agricultural and food chemistry

Yang Y,Sun Q,Xu X,Yang X,Gao Y,Sun X,Zhao Y,Ding Z,Ge W,Cheng R,Zhang J

Wed Dec 04 00:00:00 UTC 2019

Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.

Toxicological sciences : an official journal of the Society of Toxicology

Bai D,Li Q,Xiong Y,Wang C,Shen P,Bai L,Yuan L,Wu P

Wed Aug 01 00:00:00 UTC 2018

Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.

Toxicological sciences : an official journal of the Society of Toxicology

Bai D,Li Q,Xiong Y,Wang C,Shen P,Bai L,Yuan L,Wu P

Wed Aug 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1); ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1); ATP-binding cassette, subfamily G, member 5; sterolin 1; Sterolin-1

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Gene Aliases: ABCG5; AW112016; cmp; sterolin-1; STSL; trac

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UniProt ID: (Human) Q9H222, (Rat) Q99PE7, (Mouse) Q99PE8

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Entrez Gene ID: (Human) 64240, (Rat) 114628, (Mouse) 27409

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Function(s)

protein binding ATP binding ATPase activity cholesterol transporter activity ATPase activity, coupled to transmembrane movement of substances protein heterodimerization activity nucleotide binding

Process(es)

response to nutrient excretion metabolic process response to ionizing radiation negative regulation of intestinal phytosterol absorption sterol transport regulation of intestinal cholesterol absorption cholesterol transport cholesterol efflux response to drug cholesterol homeostasis negative regulation of intestinal cholesterol absorption intestinal cholesterol absorption transmembrane transport transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ABCG5 Polyclonal Antibody

ABCG5 Antibody (27722-1-AP) in IHC (P)

Product Details

27722-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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