Invitrogen

ABL2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78707

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived human ABL2 recombinant protein (Position: T1065-R1182).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745823

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat brain tissue, rat PC-12 whole cell, mouse brain tissue, mouse NIH/3T3 whole cell, huamn K562 whole cell. IHC: human gallbladder carcinoma tissue, mouse brain tissue.

Target Information

ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl1-related gene product; abl2; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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Gene Aliases: AA536808; ABL2; ABLL; ARG

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UniProt ID: (Human) P42684

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Entrez Gene ID: (Human) 27, (Mouse) 11352, (Rat) 304883

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Function(s)
magnesium ion binding actin monomer binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding manganese ion binding actin filament binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding molecular_function
Process(es)
cellular protein modification process cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration regulation of autophagy positive regulation of phospholipase C activity positive regulation of neuron projection development cell migration peptidyl-tyrosine phosphorylation actin cytoskeleton organization regulation of endocytosis regulation of cell adhesion peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response positive regulation of oxidoreductase activity cellular response to retinoic acid regulation of cell motility regulation of actin cytoskeleton reorganization protein phosphorylation phagocytosis substrate-dependent cell migration, cell extension actin filament organization epidermal growth factor receptor signaling pathway learning visual learning phosphorylation neuron remodeling cerebellum morphogenesis negative regulation of cell-cell adhesion positive regulation of protein binding cellular protein localization negative regulation of Rho protein signal transduction exploration behavior positive regulation of I-kappaB kinase/NF-kappaB signaling alpha-beta T cell differentiation platelet-derived growth factor receptor signaling pathway dendrite morphogenesis neuromuscular process controlling balance actin filament bundle assembly Bergmann glial cell differentiation positive regulation of ERK1 and ERK2 cascade dendritic spine maintenance positive regulation of interleukin-2 secretion positive regulation of interferon-gamma secretion regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process biological_process cell differentiation regulation of apoptotic process
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