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Abnova
ABL2 Monoclonal Antibody (6D5)
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ABL2 Antibody (H00000027-M03) in WB
Western blot analysis of ABL2 over-expressed 293 cell line, cotransfected with ABL2 Validated Chimera RNAi (Cat # H00000027-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with ABL2 monoclonal antibody (M03) clone 6D5 (Cat # H00000027-M03). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Product Details
H00000027-M03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6D5
Immunogen
ABL2 (AAH65912, 743 a.a. approximately 842 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: KKTLGLRAGK PTASDDTSKP FPRSNSTSSM SSGLPEQDRM AMTLPRNCQR SKLQLERTVS TSSQPEENVD RANDMLPKKS EESAAPSRER PKAKLLPRGA
Target Information
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2
Gene Aliases: ABL2; ABLL; ARG
UniProt ID: (Human) P42684
Entrez Gene ID: (Human) 27
cellular protein modification process
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
positive regulation of phospholipase C activity
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
regulation of endocytosis
regulation of cell adhesion
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
positive regulation of oxidoreductase activity
cellular response to retinoic acid
regulation of cell motility
regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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