Proteintech

ACAA1 Polyclonal Antibody

ACAA1 Antibody in Immunocytochemistry (ICC/IF)

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ACAA1 Antibody (12319-2-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed U-251 cells using (Product # 12319-2-AP) (ACAA1 antibody), at dilution of 1:500 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ACAA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

12319-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACAA1 Fusion Protein Ag2972 (117-424 aa encoded by BC011977)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: STVNRQCSS GLQAVASIAG GIRNGSYDIG MACGVESMSL ADRGNPGNIT SRLMEKEKAR DCLIPMGITS ENVAERFGIS REKQDTFALA SQQKAARAQS KGCFQAEIVP VTTTVHDDKG TKRSITVTQD EGIRPSTTME GLAKLKPAFK KDGSTTAGNS SQVSDGAAAI LLARRSKAEE LGLPILGVLR SYAVVGVPPD IMGIGPAYAI PVALQKAGLT VSDVDIFEIN EAFASQAAYC VEKLRLPPEK VNPLGGAVAL GHPLGCTGAR QVITLLNELK RRGKRAYGVV SMCIGTGMGA AAVFEYPGN (117-424 aa encoded by BC011977)

Target Information

This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.

Communications biology

Landowski M,Bhute VJ,Grindel S,Haugstad Z,Gyening YK,Tytanic M,Brush RS,Moyer LJ,Nelson DW,Davis CR,Yen CE,Ikeda S,Agbaga MP,Ikeda A

Wed Jan 04 00:00:00 UTC 2023

Comparative Genomic Analysis of the Thiolase Family and Functional Characterization of the Acetyl-Coenzyme A Acyltransferase-1 Gene for Milk Biosynthesis and Production of Buffalo and Cattle.

Journal of agricultural and food chemistry

Deng T,Wu J,Abdel-Shafy H,Wang X,Lv H,Shaukat A,Zhou X,Zhou Y,Sun H,Wei P,Sun N,Huang Q,Xu L,Liu M,Lin Y,Yang L,Hua G

Mon Feb 13 00:00:00 UTC 2023

Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver.

Proteomics

Ran H,Sun W,Wang L,Wang X,Yu H,Chen J,Liu F,Chao Z,Pu Q,Liu Y,Zeng Y,Li Z,Wan Y,Yuan J

Sun Oct 01 00:00:00 UTC 2023

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis.

Cellular and molecular life sciences : CMLS

Ranea-Robles P,Violante S,Argmann C,Dodatko T,Bhattacharya D,Chen H,Yu C,Friedman SL,Puchowicz M,Houten SM

Thu Jul 01 00:00:00 UTC 2021

Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice.

Kidney360

Ranea-Robles P,Portman K,Bender A,Lee K,He JC,Mulholland DJ,Argmann C,Houten SM

Wed Sep 01 00:00:00 UTC 2021

Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.

International journal of oncology

Ye L,Chen T,Cao J,Sun L,Li W,Zhang C

Sun Nov 01 00:00:00 UTC 2020

High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.

International journal of molecular sciences

Xu L,Xia H,Ni D,Hu Y,Liu J,Qin Y,Zhou Q,Yi Q,Xie Y

Sat Mar 07 00:00:00 UTC 2020

Proteomic Analysis of Lysosomal Membrane Proteins in Bovine Mammary Epithelial Cells Illuminates Potential Novel Lysosome Functions in Lactation.

Journal of agricultural and food chemistry

Luo C,Zhao S,Dai W,Zheng N,Wang J

Wed Dec 12 00:00:00 UTC 2018

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

EBioMedicine

Lyu Z,Mao Z,Li Q,Xia Y,Liu Y,He Q,Wang Y,Zhao H,Lu Z,Zhou Q

Sat Dec 01 00:00:00 UTC 2018

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

EBioMedicine

Lyu Z,Mao Z,Li Q,Xia Y,Liu Y,He Q,Wang Y,Zhao H,Lu Z,Zhou Q

Sat Dec 01 00:00:00 UTC 2018

Super-resolution imaging reveals the sub-diffraction phenotype of Zellweger Syndrome ghosts and wild-type peroxisomes.

Scientific reports

Soliman K,Göttfert F,Rosewich H,Thoms S,Gärtner J

Thu May 17 00:00:00 UTC 2018

Super-resolution imaging reveals the sub-diffraction phenotype of Zellweger Syndrome ghosts and wild-type peroxisomes.

Scientific reports

Soliman K,Göttfert F,Rosewich H,Thoms S,Gärtner J

Thu May 17 00:00:00 UTC 2018

In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice.

Biochimie

Richert S,Kleinecke S,Günther J,Schaumburg F,Edgar J,Nienhaus GU,Nave KA,Kassmann CM

Sat Mar 01 00:00:00 UTC 2014

In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice.

Biochimie

Richert S,Kleinecke S,Günther J,Schaumburg F,Edgar J,Nienhaus GU,Nave KA,Kassmann CM

Sat Mar 01 00:00:00 UTC 2014

Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.

Human molecular genetics

Krause C,Rosewich H,Woehler A,Gärtner J

Tue Oct 01 00:00:00 UTC 2013

Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.

Human molecular genetics

Krause C,Rosewich H,Woehler A,Gärtner J

Tue Oct 01 00:00:00 UTC 2013

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

FEBS letters

Kassmann CM,Quintes S,Rietdorf J,Möbius W,Sereda MW,Nientiedt T,Saher G,Baes M,Nave KA

Thu Jul 21 00:00:00 UTC 2011

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

FEBS letters

Kassmann CM,Quintes S,Rietdorf J,Möbius W,Sereda MW,Nientiedt T,Saher G,Baes M,Nave KA

Thu Jul 21 00:00:00 UTC 2011

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

FEBS letters

Kassmann CM,Quintes S,Rietdorf J,Möbius W,Sereda MW,Nientiedt T,Saher G,Baes M,Nave KA

Thu Jul 21 00:00:00 UTC 2011

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.

FEBS letters

Kassmann CM,Quintes S,Rietdorf J,Möbius W,Sereda MW,Nientiedt T,Saher G,Baes M,Nave KA

Thu Jul 21 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 3-ketoacyl-CoA thiolase A, peroxisomal; 3-ketoacyl-CoA thiolase B, peroxisomal; 3-ketoacyl-CoA thiolase, peroxisomal; Acetyl-CoA acyltransferase; acetyl-CoA acyltransferase 1A; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; Acetyl-CoA acyltransferase A; Acetyl-CoA acyltransferase B; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; Acetyl-CoA C-myristoyltransferase; acetyl-Coenzyme A acyltransferase 1; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase); acetyl-Coenzyme A acyltransferase 1A; Beta-ketothiolase; Beta-ketothiolase A; Beta-ketothiolase B; peroxisomal 3-ketoacyl-CoA thiolase; peroxisomal 3-ketoacyl-CoA thiolase B; Peroxisomal 3-oxoacyl-CoA thiolase; Peroxisomal 3-oxoacyl-CoA thiolase A; Peroxisomal 3-oxoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-Coenzyme A thiolase; testicular tissue protein Li 197; Thiolase A; thiolase B

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Gene Aliases: ACAA; ACAA1; Acaa1a; Acaa1b; D9Ertd25e; Pktaa; PTHIO; PTL; RGD1562373; THIO

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UniProt ID: (Human) P09110, (Mouse) Q921H8, (Rat) P21775, (Rat) P07871, (Mouse) Q8VCH0

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Entrez Gene ID: (Human) 30, (Mouse) 113868, (Rat) 24157, (Rat) 501072, (Mouse) 235674

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Function(s)

acetyl-CoA C-acyltransferase activity protein binding acetate CoA-transferase activity palmitoyl-CoA oxidase activity catalytic activity acetyl-CoA C-acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups

Process(es)

very long-chain fatty acid metabolic process lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation metabolic process bile acid metabolic process fatty acid beta-oxidation using acyl-CoA oxidase alpha-linolenic acid metabolic process response to nutrient response to drug response to steroid hormone

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACAA1 Polyclonal Antibody

ACAA1 Antibody (12319-2-AP) in ICC/IF

Product Details

12319-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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