Proteintech

ACADM Polyclonal Antibody

ACADM Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACADM Antibody (55210-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 55210-1-AP) (ACADM antibody) at dilution of 1:150 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

55210-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 33 publications 33 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ACADM.

Target Information

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

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Protective effects of dioscin against alcohol-induced liver injury.

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Protective effects of dioscin against alcohol-induced liver injury.

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High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.

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HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Cell reports

Huang D,Li T,Li X,Zhang L,Sun L,He X,Zhong X,Jia D,Song L,Semenza GL,Gao P,Zhang H

Thu Sep 25 00:00:00 UTC 2014

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Cell reports

Huang D,Li T,Li X,Zhang L,Sun L,He X,Zhong X,Jia D,Song L,Semenza GL,Gao P,Zhang H

Thu Sep 25 00:00:00 UTC 2014

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

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Bioinformatics

Protein Aliases: acyl-CoA dehydrogenase C-4 to C-12 straight chain; Acyl-Coenzyme A dehydrogenase C-4 to C-12 straight-chain; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain; acyl-Coenzyme A dehydrogenase, medium chain; FLJ18227; FLJ93013; FLJ99884; MCAD; MCADH; Medium chain acyl-CoA dehydrogenase; medium-chain acyl-CoA dehydrogenase; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; RP4-682C21.1; testicular tissue protein Li 7

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Gene Aliases: ACAD1; ACADM; AU018656; MCAD; MCADH

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UniProt ID: (Human) P11310, (Mouse) P45952, (Rat) P08503

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Entrez Gene ID: (Human) 34, (Mouse) 11364, (Rat) 24158

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Function(s)

fatty-acyl-CoA binding acyl-CoA dehydrogenase activity electron carrier activity identical protein binding flavin adenine dinucleotide binding oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor medium-chain-acyl-CoA dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors isomerase activity

Process(es)

liver development glycogen biosynthetic process organic acid metabolic process regulation of gluconeogenesis lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation heart development metabolic process response to cold carnitine metabolic process post-embryonic development carnitine metabolic process, CoA-linked fatty acid beta-oxidation using acyl-CoA dehydrogenase response to starvation carnitine biosynthetic process protein homotetramerization medium-chain fatty acid metabolic process medium-chain fatty acid catabolic process cardiac muscle cell differentiation oxidation-reduction process response to nutrient response to hormone response to drug response to copper ion response to glucocorticoid lipid homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACADM Polyclonal Antibody

ACADM Antibody (55210-1-AP) in IHC (P)

Product Details

55210-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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