Proteintech

ACAT2 Polyclonal Antibody

ACAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACAT2 Antibody (14755-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 14755-1-AP (ACAT2 antibody) at dilution of 1:100 (under 40x lens).

ACAT2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14755-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACAT2 Fusion Protein Ag6503 (1-397 aa encoded by BC000408)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNAGSDPVV IVSAARTIIG SFNGALAAVP VQDLGSTVIK EVLKRATVAP EDVSEVIFGH VLAAGCGQNP VRQASVGAGI PYSVPAWSCQ MICGSGLKAV CLAVQSIGIG DSSIVVAGGM ENMSKAPHLA YLRTGVKIGE MPLTDSILCD GLTDAFHNCH MGITAENVAK KWQVSREDQD KVAVLSQNRT ENAQKAGHFD KEIVPVLVST RRGLIEVKTD EFPRHGSNIE AMSKLKPYFL TDGTGTVTPA NASGINDGAA AVVLMKKSEA DKRGLTPLAR IVSWSQVGVE PSIMGIGPIP AIKQAVTKAG WSLEDVDIFE INEAFAAVSA AIVKELGLNP EKVNIEGGAI ALGHPLGASG CRILVTLLHT LERMGRSRGV AALCIGGGMG IAMCVQRE (1-397 aa encoded by BC000408)

Target Information

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.

International journal of radiation oncology, biology, physics

Heng J,Li Z,Liu L,Zheng Z,Zheng Y,Xu X,Liao L,Xu H,Huang H,Li E,Xu L

Wed Nov 15 00:00:00 UTC 2023

Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.

International journal of radiation oncology, biology, physics

Heng J,Li Z,Liu L,Zheng Z,Zheng Y,Xu X,Liao L,Xu H,Huang H,Li E,Xu L

Wed Nov 15 00:00:00 UTC 2023

Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.

Cancer cell international

Zhang E,Ding C,Li S,Aikemu B,Zhou X,Fan X,Sun J,Yang X,Zheng M

Thu May 18 00:00:00 UTC 2023

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.

iScience

Dalton GD,Oh SH,Tang L,Zhang S,Brown AL,Varadharajan V,Baleanu-Gogonea C,Gogonea V,Pathak P,Brown JM,Diehl AM

Fri Sep 24 00:00:00 UTC 2021

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.

Cell research

Guo Y,Zhao M,Bo T,Ma S,Yuan Z,Chen W,He Z,Hou X,Liu J,Zhang Z,Zhu Q,Wang Q,Lin X,Yang Z,Cui M,Liu L,Li Y,Yu C,Qi X,Wang Q,Zhang H,Guan Q,Zhao L,Xuan S,Yan H,Lin Y,Wang L,Li Q,Song Y,Gao L,Zhao J

Fri Feb 01 00:00:00 UTC 2019

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.

Cell research

Guo Y,Zhao M,Bo T,Ma S,Yuan Z,Chen W,He Z,Hou X,Liu J,Zhang Z,Zhu Q,Wang Q,Lin X,Yang Z,Cui M,Liu L,Li Y,Yu C,Qi X,Wang Q,Zhang H,Guan Q,Zhao L,Xuan S,Yan H,Lin Y,Wang L,Li Q,Song Y,Gao L,Zhao J

Fri Feb 01 00:00:00 UTC 2019

Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells.

Biochemical and biophysical research communications

Ma C,Chen H,Zhang S,Yan Y,Wu R,Wang Y,Liu Y,Yang L,Liu M

Tue Oct 15 00:00:00 UTC 2019

Oral Administration of Succinoglycan Riclin Improves Diet-Induced Hypercholesterolemia in Mice.

Journal of agricultural and food chemistry

Yang Y,Sun Q,Xu X,Yang X,Gao Y,Sun X,Zhao Y,Ding Z,Ge W,Cheng R,Zhang J

Wed Dec 04 00:00:00 UTC 2019

Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo.

Food research international (Ottawa, Ont.)

Liu S,You L,Zhao Y,Chang X

Tue May 01 00:00:00 UTC 2018

Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo.

Food research international (Ottawa, Ont.)

Liu S,You L,Zhao Y,Chang X

Tue May 01 00:00:00 UTC 2018

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.

Cell research

Huang D,Li T,Wang L,Zhang L,Yan R,Li K,Xing S,Wu G,Hu L,Jia W,Lin SC,Dang CV,Song L,Gao P,Zhang H

Sat Oct 01 00:00:00 UTC 2016

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.

Cell research

Huang D,Li T,Wang L,Zhang L,Yan R,Li K,Xing S,Wu G,Hu L,Jia W,Lin SC,Dang CV,Song L,Gao P,Zhang H

Sat Oct 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: acetoacetyl Coenzyme A thiolase; Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; AE1; BND3; CD233; Cytosolic acetoacetyl-CoA thiolase; DI; EMPB3; EPB3; FR; RTA1A; SW; t-complex protein 1, related sequence 1; WD; WD1; WR

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Gene Aliases: Ab2-076; ACAT2; Acat3; ACTL; AW742799; Tcp-1x; Tcp1-rs1

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UniProt ID: (Human) Q9BWD1, (Rat) Q5XI22, (Mouse) Q8CAY6

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Entrez Gene ID: (Human) 39, (Rat) 308100, (Mouse) 110460

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Function(s)

acetyl-CoA C-acetyltransferase activity protein binding transferase activity, transferring acyl groups other than amino-acyl groups catalytic activity transferase activity transferase activity, transferring acyl groups

Process(es)

lipid metabolic process liver development brain development metabolic process cellular response to nutrient ketone body catabolic process cellular response to fatty acid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACAT2 Polyclonal Antibody

ACAT2 Antibody (14755-1-AP) in IHC (P)

Product Details

14755-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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