Invitrogen

ACE Monoclonal Antibody (6C3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32956

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

6C3

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human ACE.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802590

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACE; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; Angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase I; dipeptidyl peptidase; Kininase II; MGC26566; peptidase P; testicular ECA

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Gene Aliases: ACE; ACE1; AW208573; CD143; DCP; DCP1; ICH; MVCD3

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UniProt ID: (Human) P12821, (Mouse) P09470

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Entrez Gene ID: (Human) 1636, (Mouse) 11421

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Function(s)
endopeptidase activity carboxypeptidase activity drug binding metallopeptidase activity exopeptidase activity tripeptidyl-peptidase activity peptidyl-dipeptidase activity zinc ion binding chloride ion binding mitogen-activated protein kinase kinase binding bradykinin receptor binding mitogen-activated protein kinase binding metallodipeptidase activity actin binding protein binding peptidase activity lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity metal ion binding beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity
Process(es)
kidney development neutrophil mediated immunity regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of systemic arterial blood pressure proteolysis peptide metabolic process spermatogenesis regulation of blood pressure posttranscriptional regulation of gene expression negative regulation of gene expression bradykinin catabolic process regulation of smooth muscle cell migration sensory perception of pain organ regeneration negative regulation of protein binding positive regulation of protein binding response to lipopolysaccharide vasoconstriction hormone catabolic process eating behavior positive regulation of apoptotic process peptide catabolic process lung alveolus development beta-amyloid metabolic process arachidonic acid secretion positive regulation of inflammatory response positive regulation of neurogenesis heart contraction regulation of angiotensin metabolic process angiogenesis involved in coronary vascular morphogenesis positive regulation of protein tyrosine kinase activity cell proliferation in bone marrow negative regulation of calcium ion import positive regulation of peptidyl-tyrosine autophosphorylation regulation of hematopoietic stem cell proliferation negative regulation of gap junction assembly positive regulation of peptidyl-cysteine S-nitrosylation blood vessel remodeling angiotensin maturation angiotensin catabolic process in blood regulation of renal output by angiotensin antigen processing and presentation of peptide antigen via MHC class I regulation of vasoconstriction mononuclear cell proliferation regulation of vasodilation hematopoietic stem cell differentiation
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