Invitrogen

ACE2 Monoclonal Antibody (CL4013)

ACE2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACE2 Antibody (MA5-31394) in IHC (P)

Immunohistochemical analysis of ACE2 in human kidney using ACE2 Monoclonal Antibody (CL4013) (Product # MA5-31394) shows strong positivity in apical membrane in cells in proximal tubules.

ACE2 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

ACE2 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines owing to their inherent genetic constitution. Relative expression of Angiotensin-converting enzyme 2 was observed in HaCaT, Hep G2 and RT4 but not in BJ and U-2 OS (DOI: 10.3892/mmr.2014.2266) using Anti-ACE2 Monoclonal Antibody (CL4013) (Product # MA5-31394) in Western Blot. {RE}

Product Details

MA5-31394

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10,000-1:20,000

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CL4013

Immunogen

Recombinant protein corresponding to Human ACE2

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2787030

Product Specific Information

Immunogen sequence: MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE D

Target Information

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells.

Reproductive biology

Fernando SR,Chen X,Cheng KW,Wong BP,Qi S,Jiang L,Kodithuwakku SP,Ng EH,Yeung WS,Lee KF

MA5-31394 was used in Immunohistochemistry to suggest that higher ACE2 expression was found in mid-secretory endometrium and the use of ACE inhibitors did not alter endometrial receptivity for embryo implantation.

Thu Sep 01 00:00:00 UTC 2022

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells.

Reproductive biology

Fernando SR,Chen X,Cheng KW,Wong BP,Qi S,Jiang L,Kodithuwakku SP,Ng EH,Yeung WS,Lee KF

Thu Sep 01 00:00:00 UTC 2022

SARS-CoV-2-Induced Pathology-Relevance to COVID-19 Pathophysiology.

Pathophysiology : the official journal of the International Society for Pathophysiology

Zinserling VA,Semenova NY,Bikmurzina AE,Kruglova NM,Rybalchenko OV,Markov AG

MA5-31394 was used in Immunohistochemistry to illustrate some aspects of pathogenesis by the appropriate histopathological changes detected in observations.

Fri Jun 10 00:00:00 UTC 2022

Viral infiltration of pancreatic islets in patients with COVID-19.

Nature communications

Steenblock C,Richter S,Berger I,Barovic M,Schmid J,Schubert U,Jarzebska N,von Mässenhausen A,Linkermann A,Schürmann A,Pablik J,Dienemann T,Evert K,Rodionov RN,Semenova NY,Zinserling VA,Gainetdinov RR,Baretton G,Lindemann D,Solimena M,Ludwig B,Bornstein SR

MA5-31394 was used in Immunohistochemistry to show that even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19.

Thu Jun 10 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: ACE 2; ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A

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Gene Aliases: ACE2; ACEH; UNQ868/PRO1885

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UniProt ID: (Human) Q9BYF1

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Entrez Gene ID: (Human) 59272

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Function(s)

virus receptor activity glycoprotein binding endopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity protein binding metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding

Process(es)

regulation of cytokine production angiotensin maturation angiotensin catabolic process in blood angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin tryptophan transport regulation of vasoconstriction receptor biosynthetic process regulation of cell proliferation regulation of vasodilation viral entry into host cell receptor-mediated virion attachment to host cell regulation of inflammatory response positive regulation of cardiac muscle contraction positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of reactive oxygen species metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACE2 Monoclonal Antibody (CL4013)

ACE2 Antibody (MA5-31394) in IHC (P)

Product Details

MA5-31394

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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