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Invitrogen
ACER2 Polyclonal Antibody
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Product Details
PA5-114249
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of Human ACER2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2884763
Product Specific Information
Immunogen sequence: DELAVLWVLM CALAMWFPRR YLPKIFRNDR GRFKVVVSVL SAVTTCLAFV
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Target Information
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acylsphingosine deacylase 3-like; alkaline CDase 2; Alkaline ceramidase 2; AlkCDase 2; ceramide hydrolase; haCER2; N-acylsphingosine amidohydrolase 3-like
Gene Aliases: ACER2; ALKCDase2; ASAH3L; PP11646
UniProt ID: (Human) Q5QJU3
Entrez Gene ID: (Human) 340485
negative regulation of cell-matrix adhesion
ceramide metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of cell death
sphingolipid biosynthetic process
response to retinoic acid
negative regulation of cell adhesion mediated by integrin
cellular response to drug
sphingosine biosynthetic process
negative regulation of protein glycosylation in Golgi
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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