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ACP5 Polyclonal Antibody

ACP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACP5 Antibody (11594-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 11594-1-AP ( ACP5 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

11594-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACP5 Fusion Protein Ag2065 (1-325 aa encoded by BC025414)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDMWTALLI LQALLLPSLA DGATPALRFV AVGDWGGVPN APFHTAREMA NAKEIARTVQ ILGADFILSL GDNFYFTGVQ DINDKRFQET FEDVFSDRSL RKVPWYVLAG NHDHLGNVSA QIAYSKISKR WNFPSPFYRL HFKIPQTNVS VAIFMLDTVT LCGNSDDFLS QQPERPRDVK LARTQLSWLK KQLAAAREDY VLVAGHYPVW SIAEHGPTHC LVKQLRPLLA TYGVTAYLCG HDHNLQYLQD ENGVGYVLSG AGNFMDPSKR HQRKVPNGYL RFHYGTEDSL GGFAYVEISS KEMTVTYIEA SGKSLFKTRL PRRARP (1-325 aa encoded by B C025414)

Target Information

Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. It is detected in human alveolar macrophages, osteoclasts, spleen and liver. Its expression is increased in spleen and monocytes of patients with Gaucher's disease; spleenocytes and circulating leukocytes of patients with hairy cell leukemia; spleen of patients with Hodgkin's lymphoma and in the sera of patients undergoing active bone turnover.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.

Redox biology

Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S

Mon May 01 00:00:00 UTC 2023

Deer Antler Reserve Mesenchyme Cell-Conditioned Medium Reduces the Destruction of Periodontitis in Mice.

Stem cells and development

Lin H,Chen Z,Guo Q,Zhang P,Tian Y,Chen H,Zhao H,Shen Y

Thu Dec 01 00:00:00 UTC 2022

Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.

Bone

Saito T,Terajima M,Taga Y,Hayashi F,Oshima S,Kasamatsu A,Okubo Y,Ito C,Toshimori K,Sunohara M,Tanzawa H,Uzawa K,Yamauchi M

Sat Jan 01 00:00:00 UTC 2022

Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

Nature communications

Hu Y,Wang Q,Yu J,Zhou Q,Deng Y,Liu J,Zhang L,Xu Y,Xiong W,Wang Y

Mon Jan 10 00:00:00 UTC 2022

Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.

Journal of periodontology

Yu Y,Jiang L,Li J,Lei L,Li H

Fri Jul 01 00:00:00 UTC 2022

Improvement of Osteoporosis in Rats With Hind-Limb Unloading Treated With Pulsed Electromagnetic Field and Whole-Body Vibration.

Physical therapy

Liu X,Gao X,Tong J,Yu L,Xu M,Zhang J

Thu Oct 06 00:00:00 UTC 2022

Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration.

Bioactive materials

Li Z,Wang H,Zhang K,Yang B,Xie X,Yang Z,Kong L,Shi P,Zhang Y,Ho YP,Zhang ZY,Li G,Bian L

Fri Jul 01 00:00:00 UTC 2022

Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone.

Frontiers in oncology

Feng W,He M,Jiang X,Liu H,Xie T,Qin Z,Huang Q,Liao S,Lin C,He J,Xu J,Ma J,Liu Y,Wei Q

Sat Sep 11 00:00:00 UTC 2021

Prognostic Significance of ACP5 in Human Gastric Cancer.

Digestive diseases (Basel, Switzerland)

An T,Liang Q,Hao T,Deng L,Lu X,Wang Y,Cheng L,Wu W,Zhang C

Fri Jul 16 00:00:00 UTC 2021

The function of the calcium channel Orai1 in osteoclast development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Robinson LJ,Soboloff J,Tourkova IL,Larrouture QC,Witt MR,Gross S,Hooper R,Samakai E,Worley PF,Barnett JB,Blair HC

Tue Jun 01 00:00:00 UTC 2021

4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.

Experimental and therapeutic medicine

Yi W,Liu T,Gao X,Xie Y,Liu M

Thu Apr 01 00:00:00 UTC 2021

Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.

Journal of cellular and molecular medicine

Qian Z,Zhong Z,Ni S,Li D,Zhang F,Zhou Y,Kang Z,Qian J,Yu B

Tue Sep 01 00:00:00 UTC 2020

Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.

Medical science monitor : international medical journal of experimental and clinical research

Ma C,Geng B,Zhang X,Li R,Yang X,Xia Y

Wed Jan 08 00:00:00 UTC 2020

Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.

Molecular therapy oncolytics

Hu Y,Yu J,Wang Q,Zhang L,Chen X,Cao Y,Zhao J,Xu Y,Jiang D,Wang Y,Xiong W

Fri Mar 27 00:00:00 UTC 2020

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.

Frontiers in pharmacology

Qi D,Liu H,Sun X,Luo D,Zhu M,Tao T,Gao C,Zhou C,Zhou W,Xiao J

Fri Feb 26 00:00:00 UTC 2021

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu M,Liu H,Sun K,Liu J,Mou Y,Qi D,Zhou C,Abudunaibi M,Tasiken B,Li J,Cheng H,Huang H

Sun Mar 01 00:00:00 UTC 2020

Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.

Journal of cellular physiology

Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

Mon Jul 01 00:00:00 UTC 2019

Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.

Journal of cellular physiology

Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H

Mon Jul 01 00:00:00 UTC 2019

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.

Frontiers in pharmacology

Zhong Z,Qian Z,Zhang X,Chen F,Ni S,Kang Z,Zhang F,Li D,Yu B

Tue Sep 29 00:00:00 UTC 2020

miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.

Journal of bone and mineral metabolism

Lou Z,Peng Z,Wang B,Li X,Li X,Zhang X

Sun Sep 01 00:00:00 UTC 2019

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1.

Hypertension (Dallas, Tex. : 1979)

Chen J,Fan J,Wang S,Sun Z

Tue May 01 00:00:00 UTC 2018

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1.

Hypertension (Dallas, Tex. : 1979)

Chen J,Fan J,Wang S,Sun Z

Tue May 01 00:00:00 UTC 2018

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Journal of cellular biochemistry

Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S

Thu Nov 01 00:00:00 UTC 2018

(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.

Journal of cellular biochemistry

Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S

Thu Nov 01 00:00:00 UTC 2018

Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.

Frontiers in pharmacology

Cai C,Liu C,Zhao L,Liu H,Li W,Guan H,Zhao L,Xiao J

Wed Sep 30 00:00:00 UTC 2020

Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.

Frontiers in pharmacology

Cai C,Liu C,Zhao L,Liu H,Li W,Guan H,Zhao L,Xiao J

Wed Sep 30 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: human purple acid phosphatase; Tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; Tartrate-resistant acid phosphatase type 5; TR-AP; TRAPase; TrATPase; Type 5 acid phosphatase

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Gene Aliases: ACP5; HPAP; TRACP5a; TRACP5b; TRAP; TrATPase

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UniProt ID: (Human) P13686

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Entrez Gene ID: (Human) 54

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Function(s)

acid phosphatase activity ferrous iron binding ferric iron binding

Process(es)

ossification riboflavin metabolic process negative regulation of cell adhesion response to zinc ion dephosphorylation osteoclast differentiation positive regulation of cell migration response to lipopolysaccharide negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production negative regulation of superoxide anion generation multicellular organismal response to stress response to L-ascorbic acid response to cytokine negative regulation of nitric oxide biosynthetic process bone resorption negative regulation of inflammatory response defense response to Gram-positive bacterium bone morphogenesis response to cholesterol

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACP5 Polyclonal Antibody

ACP5 Antibody (11594-1-AP) in IHC (P)

Product Details

11594-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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